#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q80Z64	uniprotkb:Q7TPV4	intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540	intact:EBI-1373622|uniprotkb:O35851|uniprotkb:Q80Y66|uniprotkb:Q8R4X2|uniprotkb:Q99KP0|ensembl:ENSMUSP00000044827	psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym)	psi-mi:mbb1a_mouse(display_long)|uniprotkb:Mybbp1a(gene name)|psi-mi:Mybbp1a(display_short)|uniprotkb:P160(gene name synonym)|uniprotkb:Myb-binding protein of 160 kDa(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Wang et al. (2006)	pubmed:17093407|imex:IM-20293	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2313455|imex:IM-20293-26	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6	refseq:NP_058056.2|dip:DIP-39831N|ensembl:ENSMUSG00000040463(gene)|ensembl:ENSMUST00000045633(transcript)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042564"(NLS-dependent protein nuclear import complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070888"(E-box binding)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:2000210"(positive regulation of anoikis)|interpro:IPR007015(DNA polymerase V)|interpro:IPR016024(Armadillo-type fold)|mint:Q7TPV4|reactome:R-MMU-5250924	-	-	-	figure legend:1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2009/04/14	2014/10/16	rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090	rogid:rt1TQLZB7JNBkpt3DooDAlzOYCo10090	intact-crc:024A6E99D7130C6C|rigid:LaIBGIPGMzVRlopMxskkH6U96N4	false	flag tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q80Z64	uniprotkb:Q8BX22	intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540	intact:EBI-2312582|uniprotkb:A2AV00|uniprotkb:Q6S7E8|uniprotkb:Q6S7E9|uniprotkb:Q7TST6|ensembl:ENSMUSP00000029061	psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym)	psi-mi:sall4_mouse(display_long)|uniprotkb:Sall4(gene name)|psi-mi:Sall4(display_short)|uniprotkb:Zinc finger protein SALL4(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Wang et al. (2006)	pubmed:17093407|imex:IM-20293	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2313455|imex:IM-20293-26	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6	refseq:NP_780512.2|refseq:NP_958797.2|refseq:NP_958798.2|dip:DIP-29926N|ensembl:ENSMUSG00000027547(gene)|ensembl:ENSMUST00000029061(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001833"(inner cell mass cell proliferation)|go:"GO:0001843"(neural tube closure)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009888"(tissue development)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021915"(neural tube development)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q8BX22|reactome:R-MMU-8943724	-	-	-	figure legend:1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2009/04/14	2014/10/16	rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090	rogid:84RTcgupqeb0ypojGiwpAezUWVw10090	intact-crc:024A6E99D7130C6C|rigid:LaIBGIPGMzVRlopMxskkH6U96N4	false	flag tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q80Z64	uniprotkb:Q8VIG1	intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540	intact:EBI-2312802|uniprotkb:A0JNY8|uniprotkb:Q155C6|uniprotkb:Q3U0W0|uniprotkb:Q4VAD6|uniprotkb:Q9CW43|ensembl:ENSMUSP00000079231|ensembl:ENSMUSP00000109076	psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym)	psi-mi:rest_mouse(display_long)|uniprotkb:Rest(gene name)|psi-mi:Rest(display_short)|uniprotkb:Nrsf(gene name synonym)|uniprotkb:Neural-restrictive silencer factor(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Wang et al. (2006)	pubmed:17093407|imex:IM-20293	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2313455|imex:IM-20293-26	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6	refseq:XP_006534905.1|refseq:NP_035393.2|ensembl:ENSMUSG00000029249(gene)|ensembl:ENSMUST00000080359(transcript)|ensembl:ENSMUST00000113449(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0032348"(negative regulation of aldosterone biosynthetic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035690"|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0060379"(cardiac muscle cell myoblast differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:1902459"(positive regulation of stem cell population maintenance)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903203"(regulation of oxidative stress-induced neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:2000065"(negative regulation of cortisol biosynthetic process)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|go:"GO:2000706"(negative regulation of dense core granule biogenesis)|go:"GO:2000740"(negative regulation of mesenchymal stem cell differentiation)|go:"GO:2000798"(negative regulation of amniotic stem cell differentiation)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR027757|interpro:IPR036236|mint:Q8VIG1|reactome:R-MMU-3214815	-	-	-	figure legend:1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2009/04/14	2014/10/16	rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090	rogid:a2nJenbqqCXCUbKM//5DZQ/hz7I10090	intact-crc:024A6E99D7130C6C|rigid:LaIBGIPGMzVRlopMxskkH6U96N4	false	flag tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q80Z64	uniprotkb:Q8VE57	intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540	intact:EBI-2312848	psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym)	psi-mi:q8ve57_mouse(display_long)|uniprotkb:Wfdc5(gene name)|psi-mi:Wfdc5(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Wang et al. (2006)	pubmed:17093407|imex:IM-20293	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2313455|imex:IM-20293-26	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6	interpro:IPR008197(Whey acidic protein, 4-disulphide core)|interpro:IPR036645|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0045087"(innate immune response)	-	-	-	figure legend:1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2009/04/14	2014/10/16	rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090	rogid:qEwCfvgqP0gYpBkl8ysZMGRB4Lk10090	intact-crc:024A6E99D7130C6C|rigid:LaIBGIPGMzVRlopMxskkH6U96N4	false	flag tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q80Z64	uniprotkb:Q6PR54	intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540	intact:EBI-2312621|uniprotkb:Q6T8D9|uniprotkb:Q7TPD8|uniprotkb:Q8BTU2|uniprotkb:Q8C408|uniprotkb:Q9CS77	psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym)	psi-mi:rif1_mouse(display_long)|uniprotkb:Rif1(gene name)|psi-mi:Rif1(display_short)|uniprotkb:Rap1-interacting factor 1 homolog(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Wang et al. (2006)	pubmed:17093407|imex:IM-20293	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2313455|imex:IM-20293-26	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6	refseq:XP_011237438.1|refseq:NP_780447.4|reactome:R-MMU-5693571|refseq:XP_006498240.1|dip:DIP-54907N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000793"(condensed chromosome)|go:"GO:0001939"(female pronucleus)|go:"GO:0001940"(male pronucleus)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006348"|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0016604"(nuclear body)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035861"(site of double-strand break)|go:"GO:0043247"(telomere maintenance in response to DNA damage)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0051233"(spindle midzone)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR022031|interpro:IPR028566	-	-	-	figure legend:1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2009/04/14	2014/10/16	rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090	rogid:OQUxpLkl6IvIwG8+hQpd84hztJs10090	intact-crc:024A6E99D7130C6C|rigid:LaIBGIPGMzVRlopMxskkH6U96N4	false	flag tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q80Z64	uniprotkb:Q62318	intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540	intact:EBI-346909|uniprotkb:P70391|uniprotkb:Q8C283|uniprotkb:Q99PN4|ensembl:ENSMUSP00000005705	psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym)	psi-mi:tif1b_mouse(display_long)|uniprotkb:Trim28(gene name)|psi-mi:Trim28(display_short)|uniprotkb:Krip1(gene name synonym)|uniprotkb:Tif1b(gene name synonym)|uniprotkb:Tripartite motif-containing protein 28(gene name synonym)|uniprotkb:KRAB-A-interacting protein(gene name synonym)|uniprotkb:KRIP-1(gene name synonym)|uniprotkb:E3 SUMO-protein ligase TRIM28(gene name synonym)|uniprotkb:Kap1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TIF1-beta(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Wang et al. (2006)	pubmed:17093407|imex:IM-20293	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2313455|imex:IM-20293-26	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6	refseq:NP_035718.2|dip:DIP-31477N|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007566"(embryo implantation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035851"(Krueppel-associated box domain binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045869"(negative regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060028"(convergent extension involved in axis elongation)|go:"GO:0060669"(embryonic placenta morphogenesis)|go:"GO:0070087"(chromo shadow domain binding)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1901536"(negative regulation of DNA demethylation)|go:"GO:1902187"|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000653"(regulation of genetic imprinting)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001487(Bromodomain)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003649(B-box, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR036427|interpro:IPR037373|interpro:IPR042713|mint:Q62318|rcsb pdb:6O5K|reactome:R-MMU-212436|ensembl:ENSMUSG00000005566(gene)|ensembl:ENSMUST00000005705(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0006468"(protein phosphorylation)	-	-	-	figure legend:1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2009/04/14	2014/10/16	rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090	rogid:DvGJxQNohVWs++QEAyrqe4ngcz810090	intact-crc:024A6E99D7130C6C|rigid:LaIBGIPGMzVRlopMxskkH6U96N4	false	flag tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q80Z64	uniprotkb:Q9ER74	intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540	intact:EBI-2312562|uniprotkb:Q920R5	psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym)	psi-mi:sall1_mouse(display_long)|uniprotkb:Sall1(gene name)|psi-mi:Sall1(display_short)|uniprotkb:Sal3(gene name synonym)|uniprotkb:Zinc finger protein Spalt-3(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Wang et al. (2006)	pubmed:17093407|imex:IM-20293	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2313455|imex:IM-20293-26	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6	dip:DIP-54906N|go:"GO:0021553"(olfactory nerve development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0021889"(olfactory bulb interneuron differentiation)|go:"GO:0021915"(neural tube development)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0031129"(inductive cell-cell signaling)|go:"GO:0035136"(forelimb morphogenesis)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003337"(mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010369"(chromocenter)|go:"GO:0016581"(NuRD complex)|go:"GO:0060173"(limb development)|go:"GO:0061034"(olfactory bulb mitral cell layer development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072073"(kidney epithelium development)|go:"GO:0072092"(ureteric bud invasion)|go:"GO:0072309"(mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|go:"GO:2000381"(negative regulation of mesoderm development)|go:"GO:2000384"(negative regulation of ectoderm development)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)	-	-	-	figure legend:1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2009/04/14	2014/10/16	rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090	rogid:Izbkv4nqxte6ww3HvP4XCCueQGg10090	intact-crc:024A6E99D7130C6C|rigid:LaIBGIPGMzVRlopMxskkH6U96N4	false	flag tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q80Z64	uniprotkb:O89090	intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540	intact:EBI-645192|uniprotkb:O89087|uniprotkb:Q62251|uniprotkb:Q64167	psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym)	psi-mi:sp1_mouse(display_long)|uniprotkb:Sp1(gene name)|psi-mi:Sp1(display_short)|uniprotkb:Specificity protein 1(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Wang et al. (2006)	pubmed:17093407|imex:IM-20293	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2313455|imex:IM-20293-26	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6	refseq:NP_038700.2|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0060136"(embryonic process involved in female pregnancy)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071837"(HMG box domain binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1904828"(positive regulation of hydrogen sulfide biosynthetic process)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|reactome:R-MMU-2173796|reactome:R-MMU-6807505|reactome:R-MMU-9018519|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030324"(lung development)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043353"(enucleate erythrocyte differentiation)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001503"(ossification)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001889"(liver development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|dip:DIP-35276N|mint:O89090	-	-	-	figure legend:1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2009/04/14	2014/10/16	rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090	rogid:yl6xflCilQfKGmNQ0vKKnbMhvIs10090	intact-crc:024A6E99D7130C6C|rigid:LaIBGIPGMzVRlopMxskkH6U96N4	false	flag tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q80Z64	uniprotkb:P70414	intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540	intact:EBI-2312694	psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym)	psi-mi:nac1_mouse(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Wang et al. (2006)	pubmed:17093407|imex:IM-20293	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2313455|imex:IM-20293-26	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6	interpro:IPR032452|refseq:NP_035536.2|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR038081|reactome:R-MMU-418359|reactome:R-MMU-425561|reactome:R-MMU-5578775|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086038"("calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential")|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)	-	-	-	figure legend:1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2009/04/14	2014/10/16	rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090	rogid:H3/AB7Lv9eNjID+TYPB4sh/NNps10090	intact-crc:024A6E99D7130C6C|rigid:LaIBGIPGMzVRlopMxskkH6U96N4	false	flag tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q80Z64	uniprotkb:Q61066	intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540	intact:EBI-2312665|uniprotkb:O09068|uniprotkb:O09147|ensembl:ENSMUSP00000026036	psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym)	psi-mi:nr0b1_mouse(display_long)|uniprotkb:Nr0b1(gene name)|psi-mi:Nr0b1(display_short)|uniprotkb:Ahch(gene name synonym)|uniprotkb:Dax1(gene name synonym)|uniprotkb:Nuclear receptor DAX-1(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Wang et al. (2006)	pubmed:17093407|imex:IM-20293	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2313455|imex:IM-20293-26	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6	refseq:NP_031456.1|dip:DIP-29929N|ensembl:ENSMUSG00000025056(gene)|ensembl:ENSMUST00000026036(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007530"(sex determination)|go:"GO:0008104"(protein localization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008406"(gonad development)|go:"GO:0008584"(male gonad development)|go:"GO:0010894"(negative regulation of steroid biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030238"(male sex determination)|go:"GO:0030325"(adrenal gland development)|go:"GO:0032448"(DNA hairpin binding)|go:"GO:0033144"(negative regulation of intracellular steroid hormone receptor signaling pathway)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050682"(AF-2 domain binding)|go:"GO:0060008"(Sertoli cell differentiation)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR025900|interpro:IPR033544|interpro:IPR035500|mint:Q61066|rcsb pdb:3F5C|reactome:R-MMU-383280	-	-	-	figure legend:1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2009/04/14	2014/10/16	rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090	rogid:I9visL2LIOpphOt23lKwCwCtulA10090	intact-crc:024A6E99D7130C6C|rigid:LaIBGIPGMzVRlopMxskkH6U96N4	false	flag tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q80Z64	uniprotkb:Q61066	intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540	intact:EBI-2312665|uniprotkb:O09068|uniprotkb:O09147|ensembl:ENSMUSP00000026036	psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym)	psi-mi:nr0b1_mouse(display_long)|uniprotkb:Nr0b1(gene name)|psi-mi:Nr0b1(display_short)|uniprotkb:Ahch(gene name synonym)|uniprotkb:Dax1(gene name synonym)|uniprotkb:Nuclear receptor DAX-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wang et al. (2006)	pubmed:17093407|imex:IM-20293	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2313034|imex:IM-20293-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6	refseq:NP_031456.1|dip:DIP-29929N|ensembl:ENSMUSG00000025056(gene)|ensembl:ENSMUST00000026036(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007530"(sex determination)|go:"GO:0008104"(protein localization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008406"(gonad development)|go:"GO:0008584"(male gonad development)|go:"GO:0010894"(negative regulation of steroid biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030238"(male sex determination)|go:"GO:0030325"(adrenal gland development)|go:"GO:0032448"(DNA hairpin binding)|go:"GO:0033144"(negative regulation of intracellular steroid hormone receptor signaling pathway)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050682"(AF-2 domain binding)|go:"GO:0060008"(Sertoli cell differentiation)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR025900|interpro:IPR033544|interpro:IPR035500|mint:Q61066|rcsb pdb:3F5C|reactome:R-MMU-383280	-	-	-	figure legend:2a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2009/04/14	2014/10/16	rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090	rogid:I9visL2LIOpphOt23lKwCwCtulA10090	intact-crc:86B83726CBB0CBEC|rigid:C1A4m7INcJxLUfuYanuRpE1DPsE	false	-	v5 tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q61066	uniprotkb:P70414	intact:EBI-2312665|uniprotkb:O09068|uniprotkb:O09147|ensembl:ENSMUSP00000026036	intact:EBI-2312694	psi-mi:nr0b1_mouse(display_long)|uniprotkb:Nr0b1(gene name)|psi-mi:Nr0b1(display_short)|uniprotkb:Ahch(gene name synonym)|uniprotkb:Dax1(gene name synonym)|uniprotkb:Nuclear receptor DAX-1(gene name synonym)	psi-mi:nac1_mouse(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wang et al. (2006)	pubmed:17093407|imex:IM-20293	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2313066|imex:IM-20293-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031456.1|dip:DIP-29929N|ensembl:ENSMUSG00000025056(gene)|ensembl:ENSMUST00000026036(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007530"(sex determination)|go:"GO:0008104"(protein localization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008406"(gonad development)|go:"GO:0008584"(male gonad development)|go:"GO:0010894"(negative regulation of steroid biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030238"(male sex determination)|go:"GO:0030325"(adrenal gland development)|go:"GO:0032448"(DNA hairpin binding)|go:"GO:0033144"(negative regulation of intracellular steroid hormone receptor signaling pathway)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050682"(AF-2 domain binding)|go:"GO:0060008"(Sertoli cell differentiation)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR025900|interpro:IPR033544|interpro:IPR035500|mint:Q61066|rcsb pdb:3F5C|reactome:R-MMU-383280	interpro:IPR032452|refseq:NP_035536.2|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR038081|reactome:R-MMU-418359|reactome:R-MMU-425561|reactome:R-MMU-5578775|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086038"("calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential")|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)	-	-	-	figure legend:2b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2009/04/14	2014/10/16	rogid:I9visL2LIOpphOt23lKwCwCtulA10090	rogid:H3/AB7Lv9eNjID+TYPB4sh/NNps10090	intact-crc:04C22A61132148C8|rigid:C2WEtHiPWI7FCn668o+j2HckVek	false	-	v5 tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q99LI5	uniprotkb:Q61066	intact:EBI-2312719|uniprotkb:Q3U063|uniprotkb:Q4FK52|ensembl:ENSMUSP00000039003|ensembl:ENSMUSP00000107677	intact:EBI-2312665|uniprotkb:O09068|uniprotkb:O09147|ensembl:ENSMUSP00000026036	psi-mi:zn281_mouse(display_long)|uniprotkb:Znf281(gene name)|psi-mi:Znf281(display_short)|uniprotkb:Zfp281(gene name synonym)	psi-mi:nr0b1_mouse(display_long)|uniprotkb:Nr0b1(gene name)|psi-mi:Nr0b1(display_short)|uniprotkb:Ahch(gene name synonym)|uniprotkb:Dax1(gene name synonym)|uniprotkb:Nuclear receptor DAX-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wang et al. (2006)	pubmed:17093407|imex:IM-20293	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2313073|imex:IM-20293-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001153723.1|refseq:NP_808311.1|dip:DIP-29927N|ensembl:ENSMUSG00000041483(gene)|ensembl:ENSMUST00000047734(transcript)|ensembl:ENSMUST00000112046(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q99LI5	refseq:NP_031456.1|dip:DIP-29929N|ensembl:ENSMUSG00000025056(gene)|ensembl:ENSMUST00000026036(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007530"(sex determination)|go:"GO:0008104"(protein localization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008406"(gonad development)|go:"GO:0008584"(male gonad development)|go:"GO:0010894"(negative regulation of steroid biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030238"(male sex determination)|go:"GO:0030325"(adrenal gland development)|go:"GO:0032448"(DNA hairpin binding)|go:"GO:0033144"(negative regulation of intracellular steroid hormone receptor signaling pathway)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050682"(AF-2 domain binding)|go:"GO:0060008"(Sertoli cell differentiation)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR025900|interpro:IPR033544|interpro:IPR035500|mint:Q61066|rcsb pdb:3F5C|reactome:R-MMU-383280	-	-	-	figure legend:2c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2009/04/14	2014/10/16	rogid:UX8iqhzIg2wktQ6TTjRVftIXybE10090	rogid:I9visL2LIOpphOt23lKwCwCtulA10090	intact-crc:937CAE7BDA230E68|rigid:KTIcLwU3PzTeqN1LteyPas5jhYg	false	v5 tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P20263	uniprotkb:Q61066	intact:EBI-1606219|uniprotkb:Q63843|ensembl:ENSMUSP00000025271	intact:EBI-2312665|uniprotkb:O09068|uniprotkb:O09147|ensembl:ENSMUSP00000026036	psi-mi:po5f1_mouse(display_long)|uniprotkb:Pou5f1(gene name)|psi-mi:Pou5f1(display_short)|uniprotkb:Oct-3(gene name synonym)|uniprotkb:Oct-4(gene name synonym)|uniprotkb:Otf-3(gene name synonym)|uniprotkb:Otf3(gene name synonym)|uniprotkb:Octamer-binding transcription factor 3(gene name synonym)|uniprotkb:NF-A3(gene name synonym)|uniprotkb:Octamer-binding protein 3(gene name synonym)|uniprotkb:Octamer-binding protein 4(gene name synonym)	psi-mi:nr0b1_mouse(display_long)|uniprotkb:Nr0b1(gene name)|psi-mi:Nr0b1(display_short)|uniprotkb:Ahch(gene name synonym)|uniprotkb:Dax1(gene name synonym)|uniprotkb:Nuclear receptor DAX-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wang et al. (2006)	pubmed:17093407|imex:IM-20293	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2313080|imex:IM-20293-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_038661.2|ensembl:ENSMUSG00000024406(gene)|ensembl:ENSMUST00000025271(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001712"(ectodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0001824"(blastocyst development)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001832"(blastocyst growth)|go:"GO:0003130"(BMP signaling pathway involved in heart induction)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009786"(regulation of asymmetric cell division)|go:"GO:0010033"(response to organic substance)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019955"(cytokine binding)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035198"(miRNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0005730"(nucleolus)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060795"(cell fate commitment involved in formation of primary germ layer)|go:"GO:0060913"(cardiac cell fate determination)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|go:"GO:0005737"(cytoplasm)|go:"GO:0070974"(POU domain binding)|go:"GO:0071837"(HMG box domain binding)|go:"GO:0090081"(regulation of heart induction by regulation of canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090308"(regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000327(POU-specific)|go:"GO:0005739"(mitochondrion)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR010982(Lambda repressor-like, DNA-binding)|interpro:IPR013847(POU)|interpro:IPR015585(POU domain class 5)|interpro:IPR017970|rcsb pdb:1OCP|rcsb pdb:3L1P|rcsb pdb:6HT5|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|dip:DIP-29931N	refseq:NP_031456.1|dip:DIP-29929N|ensembl:ENSMUSG00000025056(gene)|ensembl:ENSMUST00000026036(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007530"(sex determination)|go:"GO:0008104"(protein localization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008406"(gonad development)|go:"GO:0008584"(male gonad development)|go:"GO:0010894"(negative regulation of steroid biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030238"(male sex determination)|go:"GO:0030325"(adrenal gland development)|go:"GO:0032448"(DNA hairpin binding)|go:"GO:0033144"(negative regulation of intracellular steroid hormone receptor signaling pathway)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050682"(AF-2 domain binding)|go:"GO:0060008"(Sertoli cell differentiation)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR025900|interpro:IPR033544|interpro:IPR035500|mint:Q61066|rcsb pdb:3F5C|reactome:R-MMU-383280	-	-	-	figure legend:2d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2009/04/14	2014/10/16	rogid:AA1LwlLApjnKYcDk+3DoqicIRlk10090	rogid:I9visL2LIOpphOt23lKwCwCtulA10090	intact-crc:A8A99F816512D172|rigid:aJM67rwaqQH8AiPR6+ELTwoy0uk	false	v5 tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6PR54	uniprotkb:Q61066	intact:EBI-2312621|uniprotkb:Q6T8D9|uniprotkb:Q7TPD8|uniprotkb:Q8BTU2|uniprotkb:Q8C408|uniprotkb:Q9CS77	intact:EBI-2312665|uniprotkb:O09068|uniprotkb:O09147|ensembl:ENSMUSP00000026036	psi-mi:rif1_mouse(display_long)|uniprotkb:Rif1(gene name)|psi-mi:Rif1(display_short)|uniprotkb:Rap1-interacting factor 1 homolog(gene name synonym)	psi-mi:nr0b1_mouse(display_long)|uniprotkb:Nr0b1(gene name)|psi-mi:Nr0b1(display_short)|uniprotkb:Ahch(gene name synonym)|uniprotkb:Dax1(gene name synonym)|uniprotkb:Nuclear receptor DAX-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wang et al. (2006)	pubmed:17093407|imex:IM-20293	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2313087|imex:IM-20293-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237438.1|refseq:NP_780447.4|reactome:R-MMU-5693571|refseq:XP_006498240.1|dip:DIP-54907N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000793"(condensed chromosome)|go:"GO:0001939"(female pronucleus)|go:"GO:0001940"(male pronucleus)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006348"|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0016604"(nuclear body)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035861"(site of double-strand break)|go:"GO:0043247"(telomere maintenance in response to DNA damage)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0051233"(spindle midzone)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR022031|interpro:IPR028566	refseq:NP_031456.1|dip:DIP-29929N|ensembl:ENSMUSG00000025056(gene)|ensembl:ENSMUST00000026036(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007530"(sex determination)|go:"GO:0008104"(protein localization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008406"(gonad development)|go:"GO:0008584"(male gonad development)|go:"GO:0010894"(negative regulation of steroid biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030238"(male sex determination)|go:"GO:0030325"(adrenal gland development)|go:"GO:0032448"(DNA hairpin binding)|go:"GO:0033144"(negative regulation of intracellular steroid hormone receptor signaling pathway)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050682"(AF-2 domain binding)|go:"GO:0060008"(Sertoli cell differentiation)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR025900|interpro:IPR033544|interpro:IPR035500|mint:Q61066|rcsb pdb:3F5C|reactome:R-MMU-383280	-	-	-	figure legend:2h|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2009/04/14	2014/10/16	rogid:OQUxpLkl6IvIwG8+hQpd84hztJs10090	rogid:I9visL2LIOpphOt23lKwCwCtulA10090	intact-crc:10EAE99744BAE37E|rigid:QhuuAQvurRjalkaSUteQh6WeKrA	false	-	v5 tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q61066	uniprotkb:Q80Z64	intact:EBI-2312665|uniprotkb:O09068|uniprotkb:O09147|ensembl:ENSMUSP00000026036	intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540	psi-mi:nr0b1_mouse(display_long)|uniprotkb:Nr0b1(gene name)|psi-mi:Nr0b1(display_short)|uniprotkb:Ahch(gene name synonym)|uniprotkb:Dax1(gene name synonym)|uniprotkb:Nuclear receptor DAX-1(gene name synonym)	psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wang et al. (2006)	pubmed:17093407|imex:IM-20293	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2312913|imex:IM-20293-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031456.1|dip:DIP-29929N|ensembl:ENSMUSG00000025056(gene)|ensembl:ENSMUST00000026036(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007530"(sex determination)|go:"GO:0008104"(protein localization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008406"(gonad development)|go:"GO:0008584"(male gonad development)|go:"GO:0010894"(negative regulation of steroid biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030238"(male sex determination)|go:"GO:0030325"(adrenal gland development)|go:"GO:0032448"(DNA hairpin binding)|go:"GO:0033144"(negative regulation of intracellular steroid hormone receptor signaling pathway)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050682"(AF-2 domain binding)|go:"GO:0060008"(Sertoli cell differentiation)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR025900|interpro:IPR033544|interpro:IPR035500|mint:Q61066|rcsb pdb:3F5C|reactome:R-MMU-383280	refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6	-	-	-	figure legend:S2a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/04/14	2014/10/16	rogid:I9visL2LIOpphOt23lKwCwCtulA10090	rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090	intact-crc:768F1ABBFC55FD5C|rigid:C1A4m7INcJxLUfuYanuRpE1DPsE	false	v5 tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P70414	uniprotkb:Q80Z64	intact:EBI-2312694	intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540	psi-mi:nac1_mouse(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wang et al. (2006)	pubmed:17093407|imex:IM-20293	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2312947|imex:IM-20293-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR032452|refseq:NP_035536.2|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR038081|reactome:R-MMU-418359|reactome:R-MMU-425561|reactome:R-MMU-5578775|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086038"("calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential")|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)	refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6	-	-	-	figure legend:S2b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/04/14	2014/10/16	rogid:H3/AB7Lv9eNjID+TYPB4sh/NNps10090	rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090	intact-crc:1E833B248D43E86A|rigid:7ocvg50tO1NJGSzJvFiKFXfKIgk	false	v5 tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q80Z64	uniprotkb:Q99LI5	intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540	intact:EBI-2312719|uniprotkb:Q3U063|uniprotkb:Q4FK52|ensembl:ENSMUSP00000039003|ensembl:ENSMUSP00000107677	psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym)	psi-mi:zn281_mouse(display_long)|uniprotkb:Znf281(gene name)|psi-mi:Znf281(display_short)|uniprotkb:Zfp281(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wang et al. (2006)	pubmed:17093407|imex:IM-20293	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2312965|imex:IM-20293-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6	refseq:NP_001153723.1|refseq:NP_808311.1|dip:DIP-29927N|ensembl:ENSMUSG00000041483(gene)|ensembl:ENSMUST00000047734(transcript)|ensembl:ENSMUST00000112046(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q99LI5	-	-	-	figure legend:S2c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/04/14	2014/10/16	rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090	rogid:UX8iqhzIg2wktQ6TTjRVftIXybE10090	intact-crc:0D99143249F447FE|rigid:Qg02MP4uIQ2hxNFNMfmSwboGRCc	false	flag tag:?-?	v5 tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q80Z64	uniprotkb:P20263	intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540	intact:EBI-1606219|uniprotkb:Q63843|ensembl:ENSMUSP00000025271	psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym)	psi-mi:po5f1_mouse(display_long)|uniprotkb:Pou5f1(gene name)|psi-mi:Pou5f1(display_short)|uniprotkb:Oct-3(gene name synonym)|uniprotkb:Oct-4(gene name synonym)|uniprotkb:Otf-3(gene name synonym)|uniprotkb:Otf3(gene name synonym)|uniprotkb:Octamer-binding transcription factor 3(gene name synonym)|uniprotkb:NF-A3(gene name synonym)|uniprotkb:Octamer-binding protein 3(gene name synonym)|uniprotkb:Octamer-binding protein 4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wang et al. (2006)	pubmed:17093407|imex:IM-20293	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2312973|imex:IM-20293-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6	refseq:NP_038661.2|ensembl:ENSMUSG00000024406(gene)|ensembl:ENSMUST00000025271(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001712"(ectodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0001824"(blastocyst development)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001832"(blastocyst growth)|go:"GO:0003130"(BMP signaling pathway involved in heart induction)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009786"(regulation of asymmetric cell division)|go:"GO:0010033"(response to organic substance)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019955"(cytokine binding)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035198"(miRNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0005730"(nucleolus)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060795"(cell fate commitment involved in formation of primary germ layer)|go:"GO:0060913"(cardiac cell fate determination)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|go:"GO:0005737"(cytoplasm)|go:"GO:0070974"(POU domain binding)|go:"GO:0071837"(HMG box domain binding)|go:"GO:0090081"(regulation of heart induction by regulation of canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090308"(regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000327(POU-specific)|go:"GO:0005739"(mitochondrion)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR010982(Lambda repressor-like, DNA-binding)|interpro:IPR013847(POU)|interpro:IPR015585(POU domain class 5)|interpro:IPR017970|rcsb pdb:1OCP|rcsb pdb:3L1P|rcsb pdb:6HT5|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|dip:DIP-29931N	-	-	-	figure legend:S2d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/04/14	2014/10/16	rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090	rogid:AA1LwlLApjnKYcDk+3DoqicIRlk10090	intact-crc:51647740E6C2762F|rigid:XJNSNcJHKJWFdYspGYfsBtVyiOw	false	flag tag:?-?	v5 tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6PR54	uniprotkb:Q80Z64	intact:EBI-2312621|uniprotkb:Q6T8D9|uniprotkb:Q7TPD8|uniprotkb:Q8BTU2|uniprotkb:Q8C408|uniprotkb:Q9CS77	intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540	psi-mi:rif1_mouse(display_long)|uniprotkb:Rif1(gene name)|psi-mi:Rif1(display_short)|uniprotkb:Rap1-interacting factor 1 homolog(gene name synonym)	psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2006)	pubmed:17093407|imex:IM-20293	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2312988|imex:IM-20293-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237438.1|refseq:NP_780447.4|reactome:R-MMU-5693571|refseq:XP_006498240.1|dip:DIP-54907N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000793"(condensed chromosome)|go:"GO:0001939"(female pronucleus)|go:"GO:0001940"(male pronucleus)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006348"|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0016604"(nuclear body)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035861"(site of double-strand break)|go:"GO:0043247"(telomere maintenance in response to DNA damage)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0051233"(spindle midzone)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR022031|interpro:IPR028566	refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6	-	-	-	figure legend:2g|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2009/04/14	2014/10/16	rogid:OQUxpLkl6IvIwG8+hQpd84hztJs10090	rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090	intact-crc:F67C0FD12263D3F7|rigid:1qLgVX2GTsCeO/GZciWOH1dpqEI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6PR54	uniprotkb:Q80Z64	intact:EBI-2312621|uniprotkb:Q6T8D9|uniprotkb:Q7TPD8|uniprotkb:Q8BTU2|uniprotkb:Q8C408|uniprotkb:Q9CS77	intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540	psi-mi:rif1_mouse(display_long)|uniprotkb:Rif1(gene name)|psi-mi:Rif1(display_short)|uniprotkb:Rap1-interacting factor 1 homolog(gene name synonym)	psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2006)	pubmed:17093407|imex:IM-20293	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2312988|imex:IM-20293-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237438.1|refseq:NP_780447.4|reactome:R-MMU-5693571|refseq:XP_006498240.1|dip:DIP-54907N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000793"(condensed chromosome)|go:"GO:0001939"(female pronucleus)|go:"GO:0001940"(male pronucleus)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006348"|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0016604"(nuclear body)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035861"(site of double-strand break)|go:"GO:0043247"(telomere maintenance in response to DNA damage)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0051233"(spindle midzone)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR022031|interpro:IPR028566	refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6	-	-	-	figure legend:2g|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2009/04/14	2014/10/16	rogid:OQUxpLkl6IvIwG8+hQpd84hztJs10090	rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090	intact-crc:F67C0FD12263D3F7|rigid:1qLgVX2GTsCeO/GZciWOH1dpqEI	false	-	biotin tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q80Z64	uniprotkb:Q6PR54	intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540	intact:EBI-2312621|uniprotkb:Q6T8D9|uniprotkb:Q7TPD8|uniprotkb:Q8BTU2|uniprotkb:Q8C408|uniprotkb:Q9CS77	psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym)	psi-mi:rif1_mouse(display_long)|uniprotkb:Rif1(gene name)|psi-mi:Rif1(display_short)|uniprotkb:Rap1-interacting factor 1 homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2006)	pubmed:17093407|imex:IM-20293	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2313153|imex:IM-20293-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6	refseq:XP_011237438.1|refseq:NP_780447.4|reactome:R-MMU-5693571|refseq:XP_006498240.1|dip:DIP-54907N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000793"(condensed chromosome)|go:"GO:0001939"(female pronucleus)|go:"GO:0001940"(male pronucleus)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006348"|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0016604"(nuclear body)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035861"(site of double-strand break)|go:"GO:0043247"(telomere maintenance in response to DNA damage)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0051233"(spindle midzone)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR022031|interpro:IPR028566	-	-	-	figure legend:2g|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2009/04/14	2014/10/16	rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090	rogid:OQUxpLkl6IvIwG8+hQpd84hztJs10090	intact-crc:40B1792713FE806D|rigid:1qLgVX2GTsCeO/GZciWOH1dpqEI	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P70414	uniprotkb:Q80Z64	intact:EBI-2312694	intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540	psi-mi:nac1_mouse(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Wang et al. (2006)	pubmed:17093407|imex:IM-20293	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2313348|imex:IM-20293-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR032452|refseq:NP_035536.2|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR038081|reactome:R-MMU-418359|reactome:R-MMU-425561|reactome:R-MMU-5578775|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086038"("calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential")|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)	refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6	-	-	-	complex-properties:4MD complex.|figure legend:S7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2009/04/14	2014/10/16	rogid:H3/AB7Lv9eNjID+TYPB4sh/NNps10090	rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090	intact-crc:BE4EF3B797E6E329|rigid:xi1DlOmNhRlB3blVnKuELVnfe1k	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P70414	uniprotkb:P22227	intact:EBI-2312694	intact:EBI-2313372|uniprotkb:Q4KMN3|uniprotkb:Q7TPU3	psi-mi:nac1_mouse(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:zfp42_mouse(display_long)|uniprotkb:Zfp42(gene name)|psi-mi:Zfp42(display_short)|uniprotkb:Rex-1(gene name synonym)|uniprotkb:Rex1(gene name synonym)|uniprotkb:Reduced expression protein 1(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Wang et al. (2006)	pubmed:17093407|imex:IM-20293	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2313348|imex:IM-20293-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR032452|refseq:NP_035536.2|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR038081|reactome:R-MMU-418359|reactome:R-MMU-425561|reactome:R-MMU-5578775|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086038"("calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential")|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)	refseq:NP_033582.2|mint:P22227|dip:DIP-54911N|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007286"(spermatid development)|go:"GO:0031519"(PcG protein complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000653"(regulation of genetic imprinting)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236	-	-	-	complex-properties:4MD complex.|figure legend:S7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2009/04/14	2014/10/16	rogid:H3/AB7Lv9eNjID+TYPB4sh/NNps10090	rogid:REI3nJ1n09QYCKp2R/9lgwV54EA10090	intact-crc:BE4EF3B797E6E329|rigid:xi1DlOmNhRlB3blVnKuELVnfe1k	false	biotin tag:?-?	biotin tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P70414	uniprotkb:Q99LI5	intact:EBI-2312694	intact:EBI-2312719|uniprotkb:Q3U063|uniprotkb:Q4FK52|ensembl:ENSMUSP00000039003|ensembl:ENSMUSP00000107677	psi-mi:nac1_mouse(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:zn281_mouse(display_long)|uniprotkb:Znf281(gene name)|psi-mi:Znf281(display_short)|uniprotkb:Zfp281(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Wang et al. (2006)	pubmed:17093407|imex:IM-20293	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2313348|imex:IM-20293-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR032452|refseq:NP_035536.2|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR038081|reactome:R-MMU-418359|reactome:R-MMU-425561|reactome:R-MMU-5578775|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086038"("calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential")|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)	refseq:NP_001153723.1|refseq:NP_808311.1|dip:DIP-29927N|ensembl:ENSMUSG00000041483(gene)|ensembl:ENSMUST00000047734(transcript)|ensembl:ENSMUST00000112046(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q99LI5	-	-	-	complex-properties:4MD complex.|figure legend:S7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2009/04/14	2014/10/16	rogid:H3/AB7Lv9eNjID+TYPB4sh/NNps10090	rogid:UX8iqhzIg2wktQ6TTjRVftIXybE10090	intact-crc:BE4EF3B797E6E329|rigid:xi1DlOmNhRlB3blVnKuELVnfe1k	false	biotin tag:?-?	biotin tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P70414	uniprotkb:Q80Z64	intact:EBI-2312694	intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540	psi-mi:nac1_mouse(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Wang et al. (2006)	pubmed:17093407|imex:IM-20293	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2313404|imex:IM-20293-24	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR032452|refseq:NP_035536.2|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR038081|reactome:R-MMU-418359|reactome:R-MMU-425561|reactome:R-MMU-5578775|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086038"("calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential")|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)	refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6	-	-	-	complex-properties:700-440kD complex.|figure legend:S7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2009/04/14	2014/10/16	rogid:H3/AB7Lv9eNjID+TYPB4sh/NNps10090	rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090	intact-crc:88FC131D657B1CF5|rigid:fHaYGFhEB/UA+zyll8hglsV+wF4	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P70414	uniprotkb:Q61066	intact:EBI-2312694	intact:EBI-2312665|uniprotkb:O09068|uniprotkb:O09147|ensembl:ENSMUSP00000026036	psi-mi:nac1_mouse(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:nr0b1_mouse(display_long)|uniprotkb:Nr0b1(gene name)|psi-mi:Nr0b1(display_short)|uniprotkb:Ahch(gene name synonym)|uniprotkb:Dax1(gene name synonym)|uniprotkb:Nuclear receptor DAX-1(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Wang et al. (2006)	pubmed:17093407|imex:IM-20293	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2313404|imex:IM-20293-24	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR032452|refseq:NP_035536.2|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR038081|reactome:R-MMU-418359|reactome:R-MMU-425561|reactome:R-MMU-5578775|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086038"("calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential")|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)	refseq:NP_031456.1|dip:DIP-29929N|ensembl:ENSMUSG00000025056(gene)|ensembl:ENSMUST00000026036(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007530"(sex determination)|go:"GO:0008104"(protein localization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008406"(gonad development)|go:"GO:0008584"(male gonad development)|go:"GO:0010894"(negative regulation of steroid biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030238"(male sex determination)|go:"GO:0030325"(adrenal gland development)|go:"GO:0032448"(DNA hairpin binding)|go:"GO:0033144"(negative regulation of intracellular steroid hormone receptor signaling pathway)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050682"(AF-2 domain binding)|go:"GO:0060008"(Sertoli cell differentiation)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR025900|interpro:IPR033544|interpro:IPR035500|mint:Q61066|rcsb pdb:3F5C|reactome:R-MMU-383280	-	-	-	complex-properties:700-440kD complex.|figure legend:S7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2009/04/14	2014/10/16	rogid:H3/AB7Lv9eNjID+TYPB4sh/NNps10090	rogid:I9visL2LIOpphOt23lKwCwCtulA10090	intact-crc:88FC131D657B1CF5|rigid:fHaYGFhEB/UA+zyll8hglsV+wF4	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P70414	uniprotkb:P22227	intact:EBI-2312694	intact:EBI-2313372|uniprotkb:Q4KMN3|uniprotkb:Q7TPU3	psi-mi:nac1_mouse(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:zfp42_mouse(display_long)|uniprotkb:Zfp42(gene name)|psi-mi:Zfp42(display_short)|uniprotkb:Rex-1(gene name synonym)|uniprotkb:Rex1(gene name synonym)|uniprotkb:Reduced expression protein 1(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Wang et al. (2006)	pubmed:17093407|imex:IM-20293	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2313404|imex:IM-20293-24	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR032452|refseq:NP_035536.2|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR038081|reactome:R-MMU-418359|reactome:R-MMU-425561|reactome:R-MMU-5578775|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086038"("calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential")|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)	refseq:NP_033582.2|mint:P22227|dip:DIP-54911N|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007286"(spermatid development)|go:"GO:0031519"(PcG protein complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000653"(regulation of genetic imprinting)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236	-	-	-	complex-properties:700-440kD complex.|figure legend:S7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2009/04/14	2014/10/16	rogid:H3/AB7Lv9eNjID+TYPB4sh/NNps10090	rogid:REI3nJ1n09QYCKp2R/9lgwV54EA10090	intact-crc:88FC131D657B1CF5|rigid:fHaYGFhEB/UA+zyll8hglsV+wF4	false	biotin tag:?-?	biotin tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P70414	uniprotkb:Q80Z64	intact:EBI-2312694	intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540	psi-mi:nac1_mouse(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Wang et al. (2006)	pubmed:17093407|imex:IM-20293	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2313416|imex:IM-20293-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR032452|refseq:NP_035536.2|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR038081|reactome:R-MMU-418359|reactome:R-MMU-425561|reactome:R-MMU-5578775|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086038"("calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential")|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)	refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6	-	-	-	complex-properties:232-158 kD complex.|figure legend:S7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2009/04/14	2014/10/16	rogid:H3/AB7Lv9eNjID+TYPB4sh/NNps10090	rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090	intact-crc:10C863248DFDF9D2|rigid:w7ZXA8nrjVHRLujAG5GU+k5sTiM	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P70414	uniprotkb:P20263	intact:EBI-2312694	intact:EBI-1606219|uniprotkb:Q63843|ensembl:ENSMUSP00000025271	psi-mi:nac1_mouse(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:po5f1_mouse(display_long)|uniprotkb:Pou5f1(gene name)|psi-mi:Pou5f1(display_short)|uniprotkb:Oct-3(gene name synonym)|uniprotkb:Oct-4(gene name synonym)|uniprotkb:Otf-3(gene name synonym)|uniprotkb:Otf3(gene name synonym)|uniprotkb:Octamer-binding transcription factor 3(gene name synonym)|uniprotkb:NF-A3(gene name synonym)|uniprotkb:Octamer-binding protein 3(gene name synonym)|uniprotkb:Octamer-binding protein 4(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Wang et al. (2006)	pubmed:17093407|imex:IM-20293	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2313416|imex:IM-20293-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR032452|refseq:NP_035536.2|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR038081|reactome:R-MMU-418359|reactome:R-MMU-425561|reactome:R-MMU-5578775|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086038"("calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential")|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)	refseq:NP_038661.2|ensembl:ENSMUSG00000024406(gene)|ensembl:ENSMUST00000025271(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001712"(ectodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0001824"(blastocyst development)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001832"(blastocyst growth)|go:"GO:0003130"(BMP signaling pathway involved in heart induction)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009786"(regulation of asymmetric cell division)|go:"GO:0010033"(response to organic substance)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019955"(cytokine binding)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035198"(miRNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0005730"(nucleolus)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060795"(cell fate commitment involved in formation of primary germ layer)|go:"GO:0060913"(cardiac cell fate determination)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|go:"GO:0005737"(cytoplasm)|go:"GO:0070974"(POU domain binding)|go:"GO:0071837"(HMG box domain binding)|go:"GO:0090081"(regulation of heart induction by regulation of canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090308"(regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000327(POU-specific)|go:"GO:0005739"(mitochondrion)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR010982(Lambda repressor-like, DNA-binding)|interpro:IPR013847(POU)|interpro:IPR015585(POU domain class 5)|interpro:IPR017970|rcsb pdb:1OCP|rcsb pdb:3L1P|rcsb pdb:6HT5|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|dip:DIP-29931N	-	-	-	complex-properties:232-158 kD complex.|figure legend:S7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2009/04/14	2014/10/16	rogid:H3/AB7Lv9eNjID+TYPB4sh/NNps10090	rogid:AA1LwlLApjnKYcDk+3DoqicIRlk10090	intact-crc:10C863248DFDF9D2|rigid:w7ZXA8nrjVHRLujAG5GU+k5sTiM	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P70414	uniprotkb:P22227	intact:EBI-2312694	intact:EBI-2313372|uniprotkb:Q4KMN3|uniprotkb:Q7TPU3	psi-mi:nac1_mouse(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:zfp42_mouse(display_long)|uniprotkb:Zfp42(gene name)|psi-mi:Zfp42(display_short)|uniprotkb:Rex-1(gene name synonym)|uniprotkb:Rex1(gene name synonym)|uniprotkb:Reduced expression protein 1(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Wang et al. (2006)	pubmed:17093407|imex:IM-20293	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2313416|imex:IM-20293-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR032452|refseq:NP_035536.2|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR038081|reactome:R-MMU-418359|reactome:R-MMU-425561|reactome:R-MMU-5578775|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086038"("calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential")|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)	refseq:NP_033582.2|mint:P22227|dip:DIP-54911N|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007286"(spermatid development)|go:"GO:0031519"(PcG protein complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000653"(regulation of genetic imprinting)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236	-	-	-	complex-properties:232-158 kD complex.|figure legend:S7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2009/04/14	2014/10/16	rogid:H3/AB7Lv9eNjID+TYPB4sh/NNps10090	rogid:REI3nJ1n09QYCKp2R/9lgwV54EA10090	intact-crc:10C863248DFDF9D2|rigid:w7ZXA8nrjVHRLujAG5GU+k5sTiM	false	biotin tag:?-?	biotin tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P70414	uniprotkb:Q80Z64	intact:EBI-2312694	intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540	psi-mi:nac1_mouse(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wang et al. (2006)	pubmed:17093407|imex:IM-20293	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2313168|imex:IM-20293-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR032452|refseq:NP_035536.2|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR038081|reactome:R-MMU-418359|reactome:R-MMU-425561|reactome:R-MMU-5578775|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086038"("calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential")|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)	refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6	-	-	-	figure legend:2f|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2009/04/14	2014/10/16	rogid:H3/AB7Lv9eNjID+TYPB4sh/NNps10090	rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090	intact-crc:22ED0FDCAE0D1488|rigid:7ocvg50tO1NJGSzJvFiKFXfKIgk	false	-	biotin tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q80Z64	uniprotkb:Q6PR54	intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540	intact:EBI-2312621|uniprotkb:Q6T8D9|uniprotkb:Q7TPD8|uniprotkb:Q8BTU2|uniprotkb:Q8C408|uniprotkb:Q9CS77	psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym)	psi-mi:rif1_mouse(display_long)|uniprotkb:Rif1(gene name)|psi-mi:Rif1(display_short)|uniprotkb:Rap1-interacting factor 1 homolog(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wang et al. (2006)	pubmed:17093407|imex:IM-20293	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2313184|imex:IM-20293-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6	refseq:XP_011237438.1|refseq:NP_780447.4|reactome:R-MMU-5693571|refseq:XP_006498240.1|dip:DIP-54907N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000793"(condensed chromosome)|go:"GO:0001939"(female pronucleus)|go:"GO:0001940"(male pronucleus)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006348"|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0016604"(nuclear body)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035861"(site of double-strand break)|go:"GO:0043247"(telomere maintenance in response to DNA damage)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0051233"(spindle midzone)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR022031|interpro:IPR028566	-	-	-	figure legend:2i|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2009/04/14	2014/10/16	rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090	rogid:OQUxpLkl6IvIwG8+hQpd84hztJs10090	intact-crc:A65A4A350088E68E|rigid:1qLgVX2GTsCeO/GZciWOH1dpqEI	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q80Z64	uniprotkb:P70414	intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540	intact:EBI-2312694	psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym)	psi-mi:nac1_mouse(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wang et al. (2006)	pubmed:17093407|imex:IM-20293	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2313191|imex:IM-20293-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6	interpro:IPR032452|refseq:NP_035536.2|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR038081|reactome:R-MMU-418359|reactome:R-MMU-425561|reactome:R-MMU-5578775|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086038"("calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential")|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)	-	-	-	figure legend:2e|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2009/04/14	2014/10/16	rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090	rogid:H3/AB7Lv9eNjID+TYPB4sh/NNps10090	intact-crc:48C1BC2ED0B9758F|rigid:7ocvg50tO1NJGSzJvFiKFXfKIgk	false	-	biotin tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q99LI5	uniprotkb:Q80Z64	intact:EBI-2312719|uniprotkb:Q3U063|uniprotkb:Q4FK52|ensembl:ENSMUSP00000039003|ensembl:ENSMUSP00000107677	intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540	psi-mi:zn281_mouse(display_long)|uniprotkb:Znf281(gene name)|psi-mi:Znf281(display_short)|uniprotkb:Zfp281(gene name synonym)	psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wang et al. (2006)	pubmed:17093407|imex:IM-20293	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2313200|imex:IM-20293-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001153723.1|refseq:NP_808311.1|dip:DIP-29927N|ensembl:ENSMUSG00000041483(gene)|ensembl:ENSMUST00000047734(transcript)|ensembl:ENSMUST00000112046(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q99LI5	refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6	-	-	-	figure legend:2e|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2009/04/14	2014/10/16	rogid:UX8iqhzIg2wktQ6TTjRVftIXybE10090	rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090	intact-crc:CF7EFFED58B5B65B|rigid:Qg02MP4uIQ2hxNFNMfmSwboGRCc	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q61066	uniprotkb:Q80Z64	intact:EBI-2312665|uniprotkb:O09068|uniprotkb:O09147|ensembl:ENSMUSP00000026036	intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540	psi-mi:nr0b1_mouse(display_long)|uniprotkb:Nr0b1(gene name)|psi-mi:Nr0b1(display_short)|uniprotkb:Ahch(gene name synonym)|uniprotkb:Dax1(gene name synonym)|uniprotkb:Nuclear receptor DAX-1(gene name synonym)	psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wang et al. (2006)	pubmed:17093407|imex:IM-20293	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2313217|imex:IM-20293-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031456.1|dip:DIP-29929N|ensembl:ENSMUSG00000025056(gene)|ensembl:ENSMUST00000026036(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007530"(sex determination)|go:"GO:0008104"(protein localization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008406"(gonad development)|go:"GO:0008584"(male gonad development)|go:"GO:0010894"(negative regulation of steroid biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030238"(male sex determination)|go:"GO:0030325"(adrenal gland development)|go:"GO:0032448"(DNA hairpin binding)|go:"GO:0033144"(negative regulation of intracellular steroid hormone receptor signaling pathway)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050682"(AF-2 domain binding)|go:"GO:0060008"(Sertoli cell differentiation)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR025900|interpro:IPR033544|interpro:IPR035500|mint:Q61066|rcsb pdb:3F5C|reactome:R-MMU-383280	refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6	-	-	-	figure legend:2e|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2009/04/14	2014/10/16	rogid:I9visL2LIOpphOt23lKwCwCtulA10090	rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090	intact-crc:BC27E8D0E7A317FD|rigid:C1A4m7INcJxLUfuYanuRpE1DPsE	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q80Z64	uniprotkb:P20263	intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540	intact:EBI-1606219|uniprotkb:Q63843|ensembl:ENSMUSP00000025271	psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym)	psi-mi:po5f1_mouse(display_long)|uniprotkb:Pou5f1(gene name)|psi-mi:Pou5f1(display_short)|uniprotkb:Oct-3(gene name synonym)|uniprotkb:Oct-4(gene name synonym)|uniprotkb:Otf-3(gene name synonym)|uniprotkb:Otf3(gene name synonym)|uniprotkb:Octamer-binding transcription factor 3(gene name synonym)|uniprotkb:NF-A3(gene name synonym)|uniprotkb:Octamer-binding protein 3(gene name synonym)|uniprotkb:Octamer-binding protein 4(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wang et al. (2006)	pubmed:17093407|imex:IM-20293	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2313224|imex:IM-20293-18	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6	refseq:NP_038661.2|ensembl:ENSMUSG00000024406(gene)|ensembl:ENSMUST00000025271(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001712"(ectodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0001824"(blastocyst development)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001832"(blastocyst growth)|go:"GO:0003130"(BMP signaling pathway involved in heart induction)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009786"(regulation of asymmetric cell division)|go:"GO:0010033"(response to organic substance)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019955"(cytokine binding)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035198"(miRNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0005730"(nucleolus)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060795"(cell fate commitment involved in formation of primary germ layer)|go:"GO:0060913"(cardiac cell fate determination)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|go:"GO:0005737"(cytoplasm)|go:"GO:0070974"(POU domain binding)|go:"GO:0071837"(HMG box domain binding)|go:"GO:0090081"(regulation of heart induction by regulation of canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090308"(regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000327(POU-specific)|go:"GO:0005739"(mitochondrion)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR010982(Lambda repressor-like, DNA-binding)|interpro:IPR013847(POU)|interpro:IPR015585(POU domain class 5)|interpro:IPR017970|rcsb pdb:1OCP|rcsb pdb:3L1P|rcsb pdb:6HT5|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|dip:DIP-29931N	-	-	-	figure legend:2e|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2009/04/14	2014/10/16	rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090	rogid:AA1LwlLApjnKYcDk+3DoqicIRlk10090	intact-crc:9035083432267E45|rigid:XJNSNcJHKJWFdYspGYfsBtVyiOw	false	-	biotin tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q80Z64	uniprotkb:Q61066	intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540	intact:EBI-2312665|uniprotkb:O09068|uniprotkb:O09147|ensembl:ENSMUSP00000026036	psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym)	psi-mi:nr0b1_mouse(display_long)|uniprotkb:Nr0b1(gene name)|psi-mi:Nr0b1(display_short)|uniprotkb:Ahch(gene name synonym)|uniprotkb:Dax1(gene name synonym)|uniprotkb:Nuclear receptor DAX-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wang et al. (2006)	pubmed:17093407|imex:IM-20293	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2313264|imex:IM-20293-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6	refseq:NP_031456.1|dip:DIP-29929N|ensembl:ENSMUSG00000025056(gene)|ensembl:ENSMUST00000026036(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007530"(sex determination)|go:"GO:0008104"(protein localization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008406"(gonad development)|go:"GO:0008584"(male gonad development)|go:"GO:0010894"(negative regulation of steroid biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030238"(male sex determination)|go:"GO:0030325"(adrenal gland development)|go:"GO:0032448"(DNA hairpin binding)|go:"GO:0033144"(negative regulation of intracellular steroid hormone receptor signaling pathway)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050682"(AF-2 domain binding)|go:"GO:0060008"(Sertoli cell differentiation)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR025900|interpro:IPR033544|interpro:IPR035500|mint:Q61066|rcsb pdb:3F5C|reactome:R-MMU-383280	-	-	-	figure legend:S2e|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/04/14	2014/10/16	rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090	rogid:I9visL2LIOpphOt23lKwCwCtulA10090	intact-crc:92228F30C385F302|rigid:C1A4m7INcJxLUfuYanuRpE1DPsE	false	flag tag:?-?	v5 tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q80Z64	uniprotkb:P70414	intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540	intact:EBI-2312694	psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym)	psi-mi:nac1_mouse(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wang et al. (2006)	pubmed:17093407|imex:IM-20293	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2313272|imex:IM-20293-20	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6	interpro:IPR032452|refseq:NP_035536.2|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR038081|reactome:R-MMU-418359|reactome:R-MMU-425561|reactome:R-MMU-5578775|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086038"("calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential")|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)	-	-	-	figure legend:S2f|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/04/14	2014/10/16	rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090	rogid:H3/AB7Lv9eNjID+TYPB4sh/NNps10090	intact-crc:5C8973160CC980BB|rigid:7ocvg50tO1NJGSzJvFiKFXfKIgk	false	flag tag:?-?	v5 tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q99LI5	uniprotkb:Q80Z64	intact:EBI-2312719|uniprotkb:Q3U063|uniprotkb:Q4FK52|ensembl:ENSMUSP00000039003|ensembl:ENSMUSP00000107677	intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540	psi-mi:zn281_mouse(display_long)|uniprotkb:Znf281(gene name)|psi-mi:Znf281(display_short)|uniprotkb:Zfp281(gene name synonym)	psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wang et al. (2006)	pubmed:17093407|imex:IM-20293	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2313280|imex:IM-20293-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001153723.1|refseq:NP_808311.1|dip:DIP-29927N|ensembl:ENSMUSG00000041483(gene)|ensembl:ENSMUST00000047734(transcript)|ensembl:ENSMUST00000112046(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q99LI5	refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6	-	-	-	figure legend:S2g|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/04/14	2014/10/16	rogid:UX8iqhzIg2wktQ6TTjRVftIXybE10090	rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090	intact-crc:7493B84D785CD03F|rigid:Qg02MP4uIQ2hxNFNMfmSwboGRCc	false	v5 tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q80Z64	uniprotkb:P20263	intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540	intact:EBI-1606219|uniprotkb:Q63843|ensembl:ENSMUSP00000025271	psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym)	psi-mi:po5f1_mouse(display_long)|uniprotkb:Pou5f1(gene name)|psi-mi:Pou5f1(display_short)|uniprotkb:Oct-3(gene name synonym)|uniprotkb:Oct-4(gene name synonym)|uniprotkb:Otf-3(gene name synonym)|uniprotkb:Otf3(gene name synonym)|uniprotkb:Octamer-binding transcription factor 3(gene name synonym)|uniprotkb:NF-A3(gene name synonym)|uniprotkb:Octamer-binding protein 3(gene name synonym)|uniprotkb:Octamer-binding protein 4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wang et al. (2006)	pubmed:17093407|imex:IM-20293	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2313289|imex:IM-20293-22	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6	refseq:NP_038661.2|ensembl:ENSMUSG00000024406(gene)|ensembl:ENSMUST00000025271(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001712"(ectodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0001824"(blastocyst development)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001832"(blastocyst growth)|go:"GO:0003130"(BMP signaling pathway involved in heart induction)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009786"(regulation of asymmetric cell division)|go:"GO:0010033"(response to organic substance)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019955"(cytokine binding)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035198"(miRNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0005730"(nucleolus)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060795"(cell fate commitment involved in formation of primary germ layer)|go:"GO:0060913"(cardiac cell fate determination)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|go:"GO:0005737"(cytoplasm)|go:"GO:0070974"(POU domain binding)|go:"GO:0071837"(HMG box domain binding)|go:"GO:0090081"(regulation of heart induction by regulation of canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090308"(regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000327(POU-specific)|go:"GO:0005739"(mitochondrion)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR010982(Lambda repressor-like, DNA-binding)|interpro:IPR013847(POU)|interpro:IPR015585(POU domain class 5)|interpro:IPR017970|rcsb pdb:1OCP|rcsb pdb:3L1P|rcsb pdb:6HT5|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|dip:DIP-29931N	-	-	-	figure legend:S2h|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/04/14	2014/10/16	rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090	rogid:AA1LwlLApjnKYcDk+3DoqicIRlk10090	intact-crc:423F94268B1B80D6|rigid:XJNSNcJHKJWFdYspGYfsBtVyiOw	false	flag tag:?-?	v5 tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q80Z64	uniprotkb:Q62318	intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540	intact:EBI-346909|uniprotkb:P70391|uniprotkb:Q8C283|uniprotkb:Q99PN4|ensembl:ENSMUSP00000005705	psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym)	psi-mi:tif1b_mouse(display_long)|uniprotkb:Trim28(gene name)|psi-mi:Trim28(display_short)|uniprotkb:Krip1(gene name synonym)|uniprotkb:Tif1b(gene name synonym)|uniprotkb:Tripartite motif-containing protein 28(gene name synonym)|uniprotkb:KRAB-A-interacting protein(gene name synonym)|uniprotkb:KRIP-1(gene name synonym)|uniprotkb:E3 SUMO-protein ligase TRIM28(gene name synonym)|uniprotkb:Kap1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TIF1-beta(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wang et al. (2006)	pubmed:17093407|imex:IM-20293	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2312516|imex:IM-20293-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6	refseq:NP_035718.2|dip:DIP-31477N|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007566"(embryo implantation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035851"(Krueppel-associated box domain binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045869"(negative regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060028"(convergent extension involved in axis elongation)|go:"GO:0060669"(embryonic placenta morphogenesis)|go:"GO:0070087"(chromo shadow domain binding)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1901536"(negative regulation of DNA demethylation)|go:"GO:1902187"|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000653"(regulation of genetic imprinting)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001487(Bromodomain)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003649(B-box, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR036427|interpro:IPR037373|interpro:IPR042713|mint:Q62318|rcsb pdb:6O5K|reactome:R-MMU-212436|ensembl:ENSMUSG00000005566(gene)|ensembl:ENSMUST00000005705(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0006468"(protein phosphorylation)	-	-	-	figure legend:1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2009/04/14	2014/10/16	rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090	rogid:DvGJxQNohVWs++QEAyrqe4ngcz810090	intact-crc:F3084A45D685E472|rigid:d3HanaOygnpg9UteUAwhPAQNoFE	false	flag tag:?-?|biotin tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q80Z64	uniprotkb:Q8BX22	intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540	intact:EBI-2312582|uniprotkb:A2AV00|uniprotkb:Q6S7E8|uniprotkb:Q6S7E9|uniprotkb:Q7TST6|ensembl:ENSMUSP00000029061	psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym)	psi-mi:sall4_mouse(display_long)|uniprotkb:Sall4(gene name)|psi-mi:Sall4(display_short)|uniprotkb:Zinc finger protein SALL4(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wang et al. (2006)	pubmed:17093407|imex:IM-20293	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2312516|imex:IM-20293-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6	refseq:NP_780512.2|refseq:NP_958797.2|refseq:NP_958798.2|dip:DIP-29926N|ensembl:ENSMUSG00000027547(gene)|ensembl:ENSMUST00000029061(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001833"(inner cell mass cell proliferation)|go:"GO:0001843"(neural tube closure)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009888"(tissue development)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021915"(neural tube development)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q8BX22|reactome:R-MMU-8943724	-	-	-	figure legend:1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2009/04/14	2014/10/16	rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090	rogid:84RTcgupqeb0ypojGiwpAezUWVw10090	intact-crc:F3084A45D685E472|rigid:d3HanaOygnpg9UteUAwhPAQNoFE	false	flag tag:?-?|biotin tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q80Z64	uniprotkb:Q6PR54	intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540	intact:EBI-2312621|uniprotkb:Q6T8D9|uniprotkb:Q7TPD8|uniprotkb:Q8BTU2|uniprotkb:Q8C408|uniprotkb:Q9CS77	psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym)	psi-mi:rif1_mouse(display_long)|uniprotkb:Rif1(gene name)|psi-mi:Rif1(display_short)|uniprotkb:Rap1-interacting factor 1 homolog(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wang et al. (2006)	pubmed:17093407|imex:IM-20293	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2312516|imex:IM-20293-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6	refseq:XP_011237438.1|refseq:NP_780447.4|reactome:R-MMU-5693571|refseq:XP_006498240.1|dip:DIP-54907N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000793"(condensed chromosome)|go:"GO:0001939"(female pronucleus)|go:"GO:0001940"(male pronucleus)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006348"|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0016604"(nuclear body)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035861"(site of double-strand break)|go:"GO:0043247"(telomere maintenance in response to DNA damage)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0051233"(spindle midzone)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR022031|interpro:IPR028566	-	-	-	figure legend:1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2009/04/14	2014/10/16	rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090	rogid:OQUxpLkl6IvIwG8+hQpd84hztJs10090	intact-crc:F3084A45D685E472|rigid:d3HanaOygnpg9UteUAwhPAQNoFE	false	flag tag:?-?|biotin tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q80Z64	uniprotkb:Q9ER74	intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540	intact:EBI-2312562|uniprotkb:Q920R5	psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym)	psi-mi:sall1_mouse(display_long)|uniprotkb:Sall1(gene name)|psi-mi:Sall1(display_short)|uniprotkb:Sal3(gene name synonym)|uniprotkb:Zinc finger protein Spalt-3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wang et al. (2006)	pubmed:17093407|imex:IM-20293	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2312516|imex:IM-20293-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6	dip:DIP-54906N|go:"GO:0021553"(olfactory nerve development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0021889"(olfactory bulb interneuron differentiation)|go:"GO:0021915"(neural tube development)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0031129"(inductive cell-cell signaling)|go:"GO:0035136"(forelimb morphogenesis)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003337"(mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010369"(chromocenter)|go:"GO:0016581"(NuRD complex)|go:"GO:0060173"(limb development)|go:"GO:0061034"(olfactory bulb mitral cell layer development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072073"(kidney epithelium development)|go:"GO:0072092"(ureteric bud invasion)|go:"GO:0072309"(mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|go:"GO:2000381"(negative regulation of mesoderm development)|go:"GO:2000384"(negative regulation of ectoderm development)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)	-	-	-	figure legend:1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2009/04/14	2014/10/16	rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090	rogid:Izbkv4nqxte6ww3HvP4XCCueQGg10090	intact-crc:F3084A45D685E472|rigid:d3HanaOygnpg9UteUAwhPAQNoFE	false	flag tag:?-?|biotin tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q80Z64	uniprotkb:Q9CXY6	intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540	intact:EBI-2312782|uniprotkb:Q3U083|uniprotkb:Q5RKG0|uniprotkb:Q8CCY9|uniprotkb:Q99KS3|ensembl:ENSMUSP00000001042	psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym)	psi-mi:ilf2_mouse(display_long)|uniprotkb:Ilf2(gene name)|psi-mi:Ilf2(display_short)|uniprotkb:Nf45(gene name synonym)|uniprotkb:Nuclear factor of activated T-cells 45 kDa(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wang et al. (2006)	pubmed:17093407|imex:IM-20293	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2312516|imex:IM-20293-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6	refseq:NP_080650.1|ensembl:ENSMUSG00000001016(gene)|ensembl:ENSMUST00000001042(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006561(DZF)|interpro:IPR043519|mint:Q9CXY6|rcsb pdb:4AT7|rcsb pdb:4AT8|rcsb pdb:4AT9|rcsb pdb:4ATB|reactome:R-MMU-6798695	-	-	-	figure legend:1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2009/04/14	2014/10/16	rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090	rogid:HwUDuY6Ev7csoTThxZCW8nJT88o10090	intact-crc:F3084A45D685E472|rigid:d3HanaOygnpg9UteUAwhPAQNoFE	false	flag tag:?-?|biotin tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q80Z64	uniprotkb:Q9CU65	intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540	intact:EBI-2312762|uniprotkb:Q3UUZ8|uniprotkb:Q3UXK7|uniprotkb:Q80XP0|uniprotkb:B2RUS2|ensembl:ENSMUSP00000022511	psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym)	psi-mi:zmym2_mouse(display_long)|uniprotkb:Zmym2(gene name)|psi-mi:Zmym2(display_short)|uniprotkb:Zfp198(gene name synonym)|uniprotkb:Znf198(gene name synonym)|uniprotkb:Zinc finger protein 198(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wang et al. (2006)	pubmed:17093407|imex:IM-20293	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2312516|imex:IM-20293-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6	refseq:XP_006519728.1|refseq:NP_083774.2|refseq:XP_017171710.1|dip:DIP-29928N|ensembl:ENSMUSG00000021945(gene)|ensembl:ENSMUST00000022511(transcript)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016605"(PML body)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|interpro:IPR010507(Zinc finger, MYM-type)|interpro:IPR011017(TRASH)|interpro:IPR021893|mint:Q9CU65	-	-	-	figure legend:1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2009/04/14	2014/10/16	rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090	rogid:gIm0LYQWUamVGDkVsYWlgKrzePw10090	intact-crc:F3084A45D685E472|rigid:d3HanaOygnpg9UteUAwhPAQNoFE	false	flag tag:?-?|biotin tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q80Z64	uniprotkb:Q8VIG1	intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540	intact:EBI-2312802|uniprotkb:A0JNY8|uniprotkb:Q155C6|uniprotkb:Q3U0W0|uniprotkb:Q4VAD6|uniprotkb:Q9CW43|ensembl:ENSMUSP00000079231|ensembl:ENSMUSP00000109076	psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym)	psi-mi:rest_mouse(display_long)|uniprotkb:Rest(gene name)|psi-mi:Rest(display_short)|uniprotkb:Nrsf(gene name synonym)|uniprotkb:Neural-restrictive silencer factor(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wang et al. (2006)	pubmed:17093407|imex:IM-20293	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2312516|imex:IM-20293-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6	refseq:XP_006534905.1|refseq:NP_035393.2|ensembl:ENSMUSG00000029249(gene)|ensembl:ENSMUST00000080359(transcript)|ensembl:ENSMUST00000113449(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0032348"(negative regulation of aldosterone biosynthetic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035690"|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0060379"(cardiac muscle cell myoblast differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:1902459"(positive regulation of stem cell population maintenance)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903203"(regulation of oxidative stress-induced neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:2000065"(negative regulation of cortisol biosynthetic process)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|go:"GO:2000706"(negative regulation of dense core granule biogenesis)|go:"GO:2000740"(negative regulation of mesenchymal stem cell differentiation)|go:"GO:2000798"(negative regulation of amniotic stem cell differentiation)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR027757|interpro:IPR036236|mint:Q8VIG1|reactome:R-MMU-3214815	-	-	-	figure legend:1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2009/04/14	2014/10/16	rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090	rogid:a2nJenbqqCXCUbKM//5DZQ/hz7I10090	intact-crc:F3084A45D685E472|rigid:d3HanaOygnpg9UteUAwhPAQNoFE	false	flag tag:?-?|biotin tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q80Z64	uniprotkb:P20263	intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540	intact:EBI-1606219|uniprotkb:Q63843|ensembl:ENSMUSP00000025271	psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym)	psi-mi:po5f1_mouse(display_long)|uniprotkb:Pou5f1(gene name)|psi-mi:Pou5f1(display_short)|uniprotkb:Oct-3(gene name synonym)|uniprotkb:Oct-4(gene name synonym)|uniprotkb:Otf-3(gene name synonym)|uniprotkb:Otf3(gene name synonym)|uniprotkb:Octamer-binding transcription factor 3(gene name synonym)|uniprotkb:NF-A3(gene name synonym)|uniprotkb:Octamer-binding protein 3(gene name synonym)|uniprotkb:Octamer-binding protein 4(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wang et al. (2006)	pubmed:17093407|imex:IM-20293	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2312516|imex:IM-20293-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6	refseq:NP_038661.2|ensembl:ENSMUSG00000024406(gene)|ensembl:ENSMUST00000025271(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001712"(ectodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0001824"(blastocyst development)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001832"(blastocyst growth)|go:"GO:0003130"(BMP signaling pathway involved in heart induction)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009786"(regulation of asymmetric cell division)|go:"GO:0010033"(response to organic substance)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019955"(cytokine binding)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035198"(miRNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0005730"(nucleolus)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060795"(cell fate commitment involved in formation of primary germ layer)|go:"GO:0060913"(cardiac cell fate determination)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|go:"GO:0005737"(cytoplasm)|go:"GO:0070974"(POU domain binding)|go:"GO:0071837"(HMG box domain binding)|go:"GO:0090081"(regulation of heart induction by regulation of canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090308"(regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000327(POU-specific)|go:"GO:0005739"(mitochondrion)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR010982(Lambda repressor-like, DNA-binding)|interpro:IPR013847(POU)|interpro:IPR015585(POU domain class 5)|interpro:IPR017970|rcsb pdb:1OCP|rcsb pdb:3L1P|rcsb pdb:6HT5|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|dip:DIP-29931N	-	-	-	figure legend:1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2009/04/14	2014/10/16	rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090	rogid:AA1LwlLApjnKYcDk+3DoqicIRlk10090	intact-crc:F3084A45D685E472|rigid:d3HanaOygnpg9UteUAwhPAQNoFE	false	flag tag:?-?|biotin tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q80Z64	uniprotkb:Q61539	intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540	intact:EBI-2312731|uniprotkb:O09067|uniprotkb:O09146|intact:EBI-5691560|uniprotkb:A2RTQ7|uniprotkb:Q8C7A6|ensembl:ENSMUSP00000021680|ensembl:ENSMUSP00000131335	psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym)	psi-mi:err2_mouse(display_long)|uniprotkb:Esrrb(gene name)|psi-mi:Esrrb(display_short)|uniprotkb:Err-2(gene name synonym)|uniprotkb:Err2(gene name synonym)|uniprotkb:Nr3b2(gene name synonym)|uniprotkb:Estrogen-related receptor beta(gene name synonym)|uniprotkb:Estrogen receptor-like 2(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group B member 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wang et al. (2006)	pubmed:17093407|imex:IM-20293	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2312516|imex:IM-20293-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6	refseq:NP_001152972.1|refseq:NP_036064.3|dip:DIP-46110N|ensembl:ENSMUSG00000021255(gene)|ensembl:ENSMUST00000021680(transcript)|ensembl:ENSMUST00000167891(transcript)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001831"(trophectodermal cellular morphogenesis)|go:"GO:0001834"(trophectodermal cell proliferation)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048839"(inner ear development)|go:"GO:0071931"(positive regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0090282"(positive regulation of transcription involved in G2/M transition of mitotic cell cycle)|go:"GO:1902459"(positive regulation of stem cell population maintenance)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000737"(negative regulation of stem cell differentiation)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR024178|interpro:IPR027289|interpro:IPR035500|reactome:R-MMU-383280|go:"GO:0000793"(condensed chromosome)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0000993"(RNA polymerase II complex binding)	-	-	-	figure legend:1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2009/04/14	2014/10/16	rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090	rogid:hF+qVAo8rJQ+YpIN6eHQ3yOSmiY10090	intact-crc:F3084A45D685E472|rigid:d3HanaOygnpg9UteUAwhPAQNoFE	false	flag tag:?-?|biotin tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q80Z64	uniprotkb:Q99LI5	intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540	intact:EBI-2312719|uniprotkb:Q3U063|uniprotkb:Q4FK52|ensembl:ENSMUSP00000039003|ensembl:ENSMUSP00000107677	psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym)	psi-mi:zn281_mouse(display_long)|uniprotkb:Znf281(gene name)|psi-mi:Znf281(display_short)|uniprotkb:Zfp281(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wang et al. (2006)	pubmed:17093407|imex:IM-20293	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2312516|imex:IM-20293-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6	refseq:NP_001153723.1|refseq:NP_808311.1|dip:DIP-29927N|ensembl:ENSMUSG00000041483(gene)|ensembl:ENSMUST00000047734(transcript)|ensembl:ENSMUST00000112046(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q99LI5	-	-	-	figure legend:1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2009/04/14	2014/10/16	rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090	rogid:UX8iqhzIg2wktQ6TTjRVftIXybE10090	intact-crc:F3084A45D685E472|rigid:d3HanaOygnpg9UteUAwhPAQNoFE	false	flag tag:?-?|biotin tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q80Z64	uniprotkb:Q8WYP5	intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540	intact:EBI-396018|uniprotkb:Q7Z4E3|uniprotkb:Q8IZA4|uniprotkb:Q96EH9|uniprotkb:Q9Y4Q6|uniprotkb:A6NGM0|uniprotkb:A8MSG9|uniprotkb:A8MZ86|ensembl:ENSP00000497061	psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym)	psi-mi:elys_human(display_long)|uniprotkb:Protein MEL-28(gene name synonym)|uniprotkb:Putative AT-hook-containing transcription factor 1(gene name synonym)|uniprotkb:AHCTF1(gene name)|psi-mi:AHCTF1(display_short)|uniprotkb:Embryonic large molecule derived from yolk sac(gene name synonym)|uniprotkb:ELYS(gene name synonym)|uniprotkb:TMBS62(gene name synonym)|uniprotkb:MSTP108(orf name)	psi-mi:"MI:0096"(pull down)	Wang et al. (2006)	pubmed:17093407|imex:IM-20293	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2312516|imex:IM-20293-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6	refseq:NP_056261.4|refseq:XP_006711821.1|refseq:NP_001310271.1|ensembl:ENSG00000153207(gene)|ensembl:ENST00000648844(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0015031"(protein transport)|go:"GO:0016363"(nuclear matrix)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0051028"(mRNA transport)|go:"GO:0051292"(nuclear pore complex assembly)|go:"GO:0051301"(cell division)|go:"GO:0070062"(extracellular exosome)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR025151|interpro:IPR032040|mint:Q8WYP5|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9615933|reactome:R-HSA-9648025	-	-	-	figure legend:1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2009/04/14	2014/10/16	rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090	rogid:ydOhjwcpt7Vl1X/urbAgH7EQrtE9606	intact-crc:F3084A45D685E472|rigid:d3HanaOygnpg9UteUAwhPAQNoFE	false	flag tag:?-?|biotin tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q80Z64	uniprotkb:O89090	intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540	intact:EBI-645192|uniprotkb:O89087|uniprotkb:Q62251|uniprotkb:Q64167	psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym)	psi-mi:sp1_mouse(display_long)|uniprotkb:Sp1(gene name)|psi-mi:Sp1(display_short)|uniprotkb:Specificity protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wang et al. (2006)	pubmed:17093407|imex:IM-20293	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2312516|imex:IM-20293-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6	refseq:NP_038700.2|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0060136"(embryonic process involved in female pregnancy)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071837"(HMG box domain binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1904828"(positive regulation of hydrogen sulfide biosynthetic process)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|reactome:R-MMU-2173796|reactome:R-MMU-6807505|reactome:R-MMU-9018519|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030324"(lung development)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043353"(enucleate erythrocyte differentiation)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001503"(ossification)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001889"(liver development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|dip:DIP-35276N|mint:O89090	-	-	-	figure legend:1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2009/04/14	2014/10/16	rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090	rogid:yl6xflCilQfKGmNQ0vKKnbMhvIs10090	intact-crc:F3084A45D685E472|rigid:d3HanaOygnpg9UteUAwhPAQNoFE	false	flag tag:?-?|biotin tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q80Z64	uniprotkb:P70288	intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540	intact:EBI-302251|uniprotkb:B2RRP3	psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym)	psi-mi:hdac2_mouse(display_long)|uniprotkb:Hdac2(gene name)|psi-mi:Hdac2(display_short)|uniprotkb:Yy1bp(gene name synonym)|uniprotkb:YY1 transcription factor-binding protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wang et al. (2006)	pubmed:17093407|imex:IM-20293	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2312516|imex:IM-20293-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6	go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:0070829"(obsolete heterochromatin maintenance)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090311"(regulation of protein deacetylation)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000757"(negative regulation of peptidyl-lysine acetylation)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR003084(Histone deacetylase)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|reactome:R-MMU-3214815|reactome:R-MMU-350054|reactome:R-MMU-4551638|reactome:R-MMU-6804758|reactome:R-MMU-73762|reactome:R-MMU-8943724|reactome:R-MMU-9022692|reactome:R-MMU-983231|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009913"(epidermal cell differentiation)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016358"(dendrite development)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016580"(Sin3 complex)|go:"GO:0016581"(NuRD complex)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019213"(deacetylase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034739"("histone deacetylase activity (H4-K16 specific)")|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0035851"(Krueppel-associated box domain binding)|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060297"(regulation of sarcomere organization)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0061198"(fungiform papilla formation)|refseq:NP_032255.2|dip:DIP-32854N|mint:P70288	-	-	-	figure legend:1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2009/04/14	2014/10/16	rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090	rogid:bGLIDKTlyhBz40NViC8calRacZ010090	intact-crc:F3084A45D685E472|rigid:d3HanaOygnpg9UteUAwhPAQNoFE	false	flag tag:?-?|biotin tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q80Z64	uniprotkb:Q8VE57	intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540	intact:EBI-2312848	psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym)	psi-mi:q8ve57_mouse(display_long)|uniprotkb:Wfdc5(gene name)|psi-mi:Wfdc5(display_short)	psi-mi:"MI:0096"(pull down)	Wang et al. (2006)	pubmed:17093407|imex:IM-20293	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2312516|imex:IM-20293-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6	interpro:IPR008197(Whey acidic protein, 4-disulphide core)|interpro:IPR036645|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0045087"(innate immune response)	-	-	-	figure legend:1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2009/04/14	2014/10/16	rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090	rogid:qEwCfvgqP0gYpBkl8ysZMGRB4Lk10090	intact-crc:F3084A45D685E472|rigid:d3HanaOygnpg9UteUAwhPAQNoFE	false	flag tag:?-?|biotin tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q80Z64	uniprotkb:Q7TPV4	intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540	intact:EBI-1373622|uniprotkb:O35851|uniprotkb:Q80Y66|uniprotkb:Q8R4X2|uniprotkb:Q99KP0|ensembl:ENSMUSP00000044827	psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym)	psi-mi:mbb1a_mouse(display_long)|uniprotkb:Mybbp1a(gene name)|psi-mi:Mybbp1a(display_short)|uniprotkb:P160(gene name synonym)|uniprotkb:Myb-binding protein of 160 kDa(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wang et al. (2006)	pubmed:17093407|imex:IM-20293	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2312516|imex:IM-20293-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6	refseq:NP_058056.2|dip:DIP-39831N|ensembl:ENSMUSG00000040463(gene)|ensembl:ENSMUST00000045633(transcript)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042564"(NLS-dependent protein nuclear import complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070888"(E-box binding)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:2000210"(positive regulation of anoikis)|interpro:IPR007015(DNA polymerase V)|interpro:IPR016024(Armadillo-type fold)|mint:Q7TPV4|reactome:R-MMU-5250924	-	-	-	figure legend:1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2009/04/14	2014/10/16	rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090	rogid:rt1TQLZB7JNBkpt3DooDAlzOYCo10090	intact-crc:F3084A45D685E472|rigid:d3HanaOygnpg9UteUAwhPAQNoFE	false	flag tag:?-?|biotin tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q80Z64	uniprotkb:P70414	intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540	intact:EBI-2312694	psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym)	psi-mi:nac1_mouse(display_long)|uniprotkb:Slc8a1(gene name)|psi-mi:Slc8a1(display_short)|uniprotkb:Ncx(gene name synonym)|uniprotkb:"Na(+)/Ca(2+)-exchange protein 1"(gene name synonym)|uniprotkb:Solute carrier family 8 member 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wang et al. (2006)	pubmed:17093407|imex:IM-20293	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2312516|imex:IM-20293-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6	interpro:IPR032452|refseq:NP_035536.2|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004836(Sodium/calcium exchanger protein)|interpro:IPR002987(Sodium/calcium exchanger, isoform 1)|interpro:IPR004837(Sodium/calcium exchanger membrane region)|interpro:IPR038081|reactome:R-MMU-418359|reactome:R-MMU-425561|reactome:R-MMU-5578775|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005432"("calcium:sodium antiporter activity")|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044557"(relaxation of smooth muscle)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055001"(muscle cell development)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086038"("calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential")|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098794"(postsynapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099580"(ion antiporter activity involved in regulation of postsynaptic membrane potential)|go:"GO:1901660"(calcium ion export)|go:"GO:1905060"("calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration")|go:"GO:0015491"("cation:cation antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033198"(response to ATP)	-	-	-	figure legend:1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2009/04/14	2014/10/16	rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090	rogid:H3/AB7Lv9eNjID+TYPB4sh/NNps10090	intact-crc:F3084A45D685E472|rigid:d3HanaOygnpg9UteUAwhPAQNoFE	false	flag tag:?-?|biotin tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q80Z64	uniprotkb:Q61066	intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540	intact:EBI-2312665|uniprotkb:O09068|uniprotkb:O09147|ensembl:ENSMUSP00000026036	psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym)	psi-mi:nr0b1_mouse(display_long)|uniprotkb:Nr0b1(gene name)|psi-mi:Nr0b1(display_short)|uniprotkb:Ahch(gene name synonym)|uniprotkb:Dax1(gene name synonym)|uniprotkb:Nuclear receptor DAX-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wang et al. (2006)	pubmed:17093407|imex:IM-20293	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2312516|imex:IM-20293-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6	refseq:NP_031456.1|dip:DIP-29929N|ensembl:ENSMUSG00000025056(gene)|ensembl:ENSMUST00000026036(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007530"(sex determination)|go:"GO:0008104"(protein localization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008406"(gonad development)|go:"GO:0008584"(male gonad development)|go:"GO:0010894"(negative regulation of steroid biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030238"(male sex determination)|go:"GO:0030325"(adrenal gland development)|go:"GO:0032448"(DNA hairpin binding)|go:"GO:0033144"(negative regulation of intracellular steroid hormone receptor signaling pathway)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050682"(AF-2 domain binding)|go:"GO:0060008"(Sertoli cell differentiation)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR025900|interpro:IPR033544|interpro:IPR035500|mint:Q61066|rcsb pdb:3F5C|reactome:R-MMU-383280	-	-	-	figure legend:1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2009/04/14	2014/10/16	rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090	rogid:I9visL2LIOpphOt23lKwCwCtulA10090	intact-crc:F3084A45D685E472|rigid:d3HanaOygnpg9UteUAwhPAQNoFE	false	flag tag:?-?|biotin tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)