#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P27986	uniprotkb:Q9UKW4	intact:EBI-79464|intact:EBI-28974553|ensembl:ENSP00000428056|ensembl:ENSP00000429277|uniprotkb:Q15747|uniprotkb:Q4VBZ7|uniprotkb:Q53EM6|uniprotkb:Q8IXA2|uniprotkb:Q8N1C5|uniprotkb:D3DWA0|uniprotkb:B3KT19|uniprotkb:E7EX19	intact:EBI-297568|uniprotkb:O95230|uniprotkb:Q9Y5X8|uniprotkb:B1APV5|uniprotkb:B1AMM0|uniprotkb:B4E232|uniprotkb:B7ZLR1|uniprotkb:E9PQ97|uniprotkb:O60498|ensembl:ENSP00000359073	psi-mi:p85a_human(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)	psi-mi:vav3_human(display_long)|uniprotkb:VAV3(gene name)|psi-mi:VAV3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hartman et al. (2006)	pubmed:16982329|mint:MINT-7033842|doi:10.1016/j.exphem.2006.05.019	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6981117|mint:MINT-7103564	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001229395.1|refseq:NP_852556.2|refseq:NP_852664.1|refseq:NP_852665.1|ensembl:ENSG00000145675(gene)|ensembl:ENST00000521381(transcript)|ensembl:ENST00000521657(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENST00000320694|ensembl:ENSP00000323512|ensembl:ENST00000336483|ensembl:ENSP00000338554|ensembl:ENSP00000428056|ensembl:ENSP00000429277|ensembl:ENST00000523872|ensembl:ENSP00000430098|rcsb pdb:5SXA|rcsb pdb:5SXB|rcsb pdb:5SXC|rcsb pdb:5SXD|rcsb pdb:5SXE|rcsb pdb:5SXF|rcsb pdb:5SXI|rcsb pdb:5SXJ|rcsb pdb:5SXK|rcsb pdb:5UBT|rcsb pdb:5UK8|rcsb pdb:5UKJ|rcsb pdb:5SX9|rcsb pdb:5UL1|rcsb pdb:5VLR|rcsb pdb:5XGH|rcsb pdb:5XGI|rcsb pdb:5XGJ|rcsb pdb:6NCT|rcsb pdb:6PYR|rcsb pdb:6PYU|reactome:R-HSA-1660499|rcsb pdb:7CIO|rcsb pdb:7LM2|reactome:R-HSA-180292|reactome:R-HSA-109704|reactome:R-HSA-1839117|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1236382|reactome:R-HSA-186763|reactome:R-HSA-1963642|reactome:R-HSA-1250342|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-1433557|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-430116|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9603381|reactome:R-HSA-9607240|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-5655291|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9027276|reactome:R-HSA-9028335|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P27986|rcsb pdb:1A0N|rcsb pdb:1AZG|rcsb pdb:1H9O|rcsb pdb:1PBW|rcsb pdb:1PHT|rcsb pdb:1PIC|rcsb pdb:1PKS|rcsb pdb:1PKT|rcsb pdb:2IUG|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|rcsb pdb:2IUH|rcsb pdb:2IUI|rcsb pdb:2RD0|rcsb pdb:3HHM|rcsb pdb:3HIZ|rcsb pdb:3I5R|rcsb pdb:3I5S|rcsb pdb:4A55|rcsb pdb:4JPS|rcsb pdb:4L1B|rcsb pdb:4L23|rcsb pdb:4L2Y|rcsb pdb:4OVU|rcsb pdb:4OVV|rcsb pdb:4WAF|rcsb pdb:4YKN|rcsb pdb:4ZOP|rcsb pdb:5AUL|rcsb pdb:5FI4|rcsb pdb:5GJI|rcsb pdb:5ITD|rcsb pdb:5M6U|rcsb pdb:5SW8|rcsb pdb:5SWG|rcsb pdb:5SWO|rcsb pdb:2V1Y|rcsb pdb:5SWP|rcsb pdb:5SWR|rcsb pdb:5SWT|rcsb pdb:5SX8|refseq:XP_016865074.1|refseq:XP_005248599.1|dip:DIP-119N|mint:MINT-7103567(identity)	refseq:NP_001073343.1|refseq:NP_006104.4|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003096(SM22/calponin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR035734|interpro:IPR035881|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:Q9UKW4|rcsb pdb:2D86|reactome:R-HSA-114604|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9664422|ensembl:ENSG00000134215(gene)|ensembl:ENST00000370056(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001772"(immunological synapse)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0006906"(vesicle fusion)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042493"|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046872"(metal ion binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|refseq:XP_005270417.1|mint:MINT-7103594(identity)	-	-	-	figure legend:f3e|comment:homomint|comment:mint|curation depth:mimix curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2009/05/25	2014/10/16	rogid:pANLtVCSWVr64OXaS6bCjGBwfig9606	rogid:sCvtyb/upL3UweAEXaHjZEkKH6M9606	intact-crc:DA5E43F9109213B4|rigid:nMpslVY0KFA5B8/vbBltAuweDXU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36888	uniprotkb:P27986	intact:EBI-3946257|uniprotkb:B7ZLT7|uniprotkb:F5H0A0|uniprotkb:A0AVG9|uniprotkb:B7ZLT8|uniprotkb:Q13414|ensembl:ENSP00000241453	intact:EBI-79464|intact:EBI-28974553|ensembl:ENSP00000428056|ensembl:ENSP00000429277|uniprotkb:Q15747|uniprotkb:Q4VBZ7|uniprotkb:Q53EM6|uniprotkb:Q8IXA2|uniprotkb:Q8N1C5|uniprotkb:D3DWA0|uniprotkb:B3KT19|uniprotkb:E7EX19	psi-mi:flt3_human(display_long)|uniprotkb:FLK2(gene name synonym)|uniprotkb:FL cytokine receptor(gene name synonym)|uniprotkb:Fetal liver kinase-2(gene name synonym)|uniprotkb:FLT3(gene name)|psi-mi:FLT3(display_short)|uniprotkb:STK1(gene name synonym)|uniprotkb:Fms-like tyrosine kinase 3(gene name synonym)|uniprotkb:Stem cell tyrosine kinase 1(gene name synonym)|uniprotkb:CD135(gene name synonym)	psi-mi:p85a_human(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hartman et al. (2006)	pubmed:16982329|mint:MINT-7033842|doi:10.1016/j.exphem.2006.05.019	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6981129|mint:MINT-7103574	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0030097"(hemopoiesis)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0097028"(dendritic cell differentiation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR030118|interpro:IPR036179|mint:P36888|rcsb pdb:1RJB|rcsb pdb:3QS7|rcsb pdb:3QS9|rcsb pdb:4RT7|rcsb pdb:4XUF|rcsb pdb:5X02|rcsb pdb:6IL3|rcsb pdb:6JQR|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-9607240|go:"GO:0035726"(common myeloid progenitor cell proliferation)|reactome:R-HSA-9645135|reactome:R-HSA-9702509|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|reactome:R-HSA-9702518|reactome:R-HSA-9702569|reactome:R-HSA-9702577|reactome:R-HSA-9702581|reactome:R-HSA-9702590|reactome:R-HSA-9702596|reactome:R-HSA-9702600|reactome:R-HSA-9702605|go:"GO:0043406"(positive regulation of MAP kinase activity)|reactome:R-HSA-9702614|reactome:R-HSA-9702620|reactome:R-HSA-9702624|reactome:R-HSA-9702632|go:"GO:0043410"(positive regulation of MAPK cascade)|reactome:R-HSA-9702636|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|reactome:R-HSA-9702998|reactome:R-HSA-9703009|reactome:R-HSA-9703648|reactome:R-HSA-9706369|reactome:R-HSA-9706374|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046651"(lymphocyte proliferation)|reactome:R-HSA-9706377|ensembl:ENSG00000122025(gene)|ensembl:ENST00000241453(transcript)|go:"GO:0001776"(leukocyte homeostasis)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|refseq:NP_004110.2|dip:DIP-59769N|mint:MINT-7103578(identity)	refseq:NP_001229395.1|refseq:NP_852556.2|refseq:NP_852664.1|refseq:NP_852665.1|ensembl:ENSG00000145675(gene)|ensembl:ENST00000521381(transcript)|ensembl:ENST00000521657(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENST00000320694|ensembl:ENSP00000323512|ensembl:ENST00000336483|ensembl:ENSP00000338554|ensembl:ENSP00000428056|ensembl:ENSP00000429277|ensembl:ENST00000523872|ensembl:ENSP00000430098|rcsb pdb:5SXA|rcsb pdb:5SXB|rcsb pdb:5SXC|rcsb pdb:5SXD|rcsb pdb:5SXE|rcsb pdb:5SXF|rcsb pdb:5SXI|rcsb pdb:5SXJ|rcsb pdb:5SXK|rcsb pdb:5UBT|rcsb pdb:5UK8|rcsb pdb:5UKJ|rcsb pdb:5SX9|rcsb pdb:5UL1|rcsb pdb:5VLR|rcsb pdb:5XGH|rcsb pdb:5XGI|rcsb pdb:5XGJ|rcsb pdb:6NCT|rcsb pdb:6PYR|rcsb pdb:6PYU|reactome:R-HSA-1660499|rcsb pdb:7CIO|rcsb pdb:7LM2|reactome:R-HSA-180292|reactome:R-HSA-109704|reactome:R-HSA-1839117|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1236382|reactome:R-HSA-186763|reactome:R-HSA-1963642|reactome:R-HSA-1250342|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-1433557|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-430116|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9603381|reactome:R-HSA-9607240|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-5655291|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9027276|reactome:R-HSA-9028335|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P27986|rcsb pdb:1A0N|rcsb pdb:1AZG|rcsb pdb:1H9O|rcsb pdb:1PBW|rcsb pdb:1PHT|rcsb pdb:1PIC|rcsb pdb:1PKS|rcsb pdb:1PKT|rcsb pdb:2IUG|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|rcsb pdb:2IUH|rcsb pdb:2IUI|rcsb pdb:2RD0|rcsb pdb:3HHM|rcsb pdb:3HIZ|rcsb pdb:3I5R|rcsb pdb:3I5S|rcsb pdb:4A55|rcsb pdb:4JPS|rcsb pdb:4L1B|rcsb pdb:4L23|rcsb pdb:4L2Y|rcsb pdb:4OVU|rcsb pdb:4OVV|rcsb pdb:4WAF|rcsb pdb:4YKN|rcsb pdb:4ZOP|rcsb pdb:5AUL|rcsb pdb:5FI4|rcsb pdb:5GJI|rcsb pdb:5ITD|rcsb pdb:5M6U|rcsb pdb:5SW8|rcsb pdb:5SWG|rcsb pdb:5SWO|rcsb pdb:2V1Y|rcsb pdb:5SWP|rcsb pdb:5SWR|rcsb pdb:5SWT|rcsb pdb:5SX8|refseq:XP_016865074.1|refseq:XP_005248599.1|dip:DIP-119N|mint:MINT-7103576(identity)	-	-	-	comment:homomint|comment:mint|figure legend:f3a f3e|curation depth:mimix curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2009/05/25	2014/10/16	rogid:Y9liE/Q9llf3LbnOegBdnVXZk3c9606	rogid:pANLtVCSWVr64OXaS6bCjGBwfig9606	intact-crc:6D546DD15F725DDA|rigid:r5bamYCXiFvdCMX2XPq0wDRGmg8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P27986	uniprotkb:P36888	intact:EBI-79464|intact:EBI-28974553|ensembl:ENSP00000428056|ensembl:ENSP00000429277|uniprotkb:Q15747|uniprotkb:Q4VBZ7|uniprotkb:Q53EM6|uniprotkb:Q8IXA2|uniprotkb:Q8N1C5|uniprotkb:D3DWA0|uniprotkb:B3KT19|uniprotkb:E7EX19	intact:EBI-3946257|uniprotkb:B7ZLT7|uniprotkb:F5H0A0|uniprotkb:A0AVG9|uniprotkb:B7ZLT8|uniprotkb:Q13414|ensembl:ENSP00000241453	psi-mi:p85a_human(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)	psi-mi:flt3_human(display_long)|uniprotkb:FLK2(gene name synonym)|uniprotkb:FL cytokine receptor(gene name synonym)|uniprotkb:Fetal liver kinase-2(gene name synonym)|uniprotkb:FLT3(gene name)|psi-mi:FLT3(display_short)|uniprotkb:STK1(gene name synonym)|uniprotkb:Fms-like tyrosine kinase 3(gene name synonym)|uniprotkb:Stem cell tyrosine kinase 1(gene name synonym)|uniprotkb:CD135(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hartman et al. (2006)	pubmed:16982329|mint:MINT-7033842|doi:10.1016/j.exphem.2006.05.019	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6981141|mint:MINT-7103585	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001229395.1|refseq:NP_852556.2|refseq:NP_852664.1|refseq:NP_852665.1|ensembl:ENSG00000145675(gene)|ensembl:ENST00000521381(transcript)|ensembl:ENST00000521657(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENST00000320694|ensembl:ENSP00000323512|ensembl:ENST00000336483|ensembl:ENSP00000338554|ensembl:ENSP00000428056|ensembl:ENSP00000429277|ensembl:ENST00000523872|ensembl:ENSP00000430098|rcsb pdb:5SXA|rcsb pdb:5SXB|rcsb pdb:5SXC|rcsb pdb:5SXD|rcsb pdb:5SXE|rcsb pdb:5SXF|rcsb pdb:5SXI|rcsb pdb:5SXJ|rcsb pdb:5SXK|rcsb pdb:5UBT|rcsb pdb:5UK8|rcsb pdb:5UKJ|rcsb pdb:5SX9|rcsb pdb:5UL1|rcsb pdb:5VLR|rcsb pdb:5XGH|rcsb pdb:5XGI|rcsb pdb:5XGJ|rcsb pdb:6NCT|rcsb pdb:6PYR|rcsb pdb:6PYU|reactome:R-HSA-1660499|rcsb pdb:7CIO|rcsb pdb:7LM2|reactome:R-HSA-180292|reactome:R-HSA-109704|reactome:R-HSA-1839117|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1236382|reactome:R-HSA-186763|reactome:R-HSA-1963642|reactome:R-HSA-1250342|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-1433557|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-430116|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9603381|reactome:R-HSA-9607240|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-5655291|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9027276|reactome:R-HSA-9028335|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P27986|rcsb pdb:1A0N|rcsb pdb:1AZG|rcsb pdb:1H9O|rcsb pdb:1PBW|rcsb pdb:1PHT|rcsb pdb:1PIC|rcsb pdb:1PKS|rcsb pdb:1PKT|rcsb pdb:2IUG|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|rcsb pdb:2IUH|rcsb pdb:2IUI|rcsb pdb:2RD0|rcsb pdb:3HHM|rcsb pdb:3HIZ|rcsb pdb:3I5R|rcsb pdb:3I5S|rcsb pdb:4A55|rcsb pdb:4JPS|rcsb pdb:4L1B|rcsb pdb:4L23|rcsb pdb:4L2Y|rcsb pdb:4OVU|rcsb pdb:4OVV|rcsb pdb:4WAF|rcsb pdb:4YKN|rcsb pdb:4ZOP|rcsb pdb:5AUL|rcsb pdb:5FI4|rcsb pdb:5GJI|rcsb pdb:5ITD|rcsb pdb:5M6U|rcsb pdb:5SW8|rcsb pdb:5SWG|rcsb pdb:5SWO|rcsb pdb:2V1Y|rcsb pdb:5SWP|rcsb pdb:5SWR|rcsb pdb:5SWT|rcsb pdb:5SX8|refseq:XP_016865074.1|refseq:XP_005248599.1|dip:DIP-119N|mint:MINT-7103587(identity)	go:"GO:0030097"(hemopoiesis)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0097028"(dendritic cell differentiation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR030118|interpro:IPR036179|mint:P36888|rcsb pdb:1RJB|rcsb pdb:3QS7|rcsb pdb:3QS9|rcsb pdb:4RT7|rcsb pdb:4XUF|rcsb pdb:5X02|rcsb pdb:6IL3|rcsb pdb:6JQR|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-9607240|go:"GO:0035726"(common myeloid progenitor cell proliferation)|reactome:R-HSA-9645135|reactome:R-HSA-9702509|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|reactome:R-HSA-9702518|reactome:R-HSA-9702569|reactome:R-HSA-9702577|reactome:R-HSA-9702581|reactome:R-HSA-9702590|reactome:R-HSA-9702596|reactome:R-HSA-9702600|reactome:R-HSA-9702605|go:"GO:0043406"(positive regulation of MAP kinase activity)|reactome:R-HSA-9702614|reactome:R-HSA-9702620|reactome:R-HSA-9702624|reactome:R-HSA-9702632|go:"GO:0043410"(positive regulation of MAPK cascade)|reactome:R-HSA-9702636|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|reactome:R-HSA-9702998|reactome:R-HSA-9703009|reactome:R-HSA-9703648|reactome:R-HSA-9706369|reactome:R-HSA-9706374|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046651"(lymphocyte proliferation)|reactome:R-HSA-9706377|ensembl:ENSG00000122025(gene)|ensembl:ENST00000241453(transcript)|go:"GO:0001776"(leukocyte homeostasis)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|refseq:NP_004110.2|dip:DIP-59769N|mint:MINT-7103589(identity)	-	-	-	comment:homomint|comment:mint|figure legend:f3a f3e f3c|curation depth:mimix curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2009/05/25	2014/10/16	rogid:pANLtVCSWVr64OXaS6bCjGBwfig9606	rogid:Y9liE/Q9llf3LbnOegBdnVXZk3c9606	intact-crc:8AB7DC81FA5CC3BC|rigid:r5bamYCXiFvdCMX2XPq0wDRGmg8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P27986	uniprotkb:Q9UKW4	intact:EBI-79464|intact:EBI-28974553|ensembl:ENSP00000428056|ensembl:ENSP00000429277|uniprotkb:Q15747|uniprotkb:Q4VBZ7|uniprotkb:Q53EM6|uniprotkb:Q8IXA2|uniprotkb:Q8N1C5|uniprotkb:D3DWA0|uniprotkb:B3KT19|uniprotkb:E7EX19	intact:EBI-297568|uniprotkb:O95230|uniprotkb:Q9Y5X8|uniprotkb:B1APV5|uniprotkb:B1AMM0|uniprotkb:B4E232|uniprotkb:B7ZLR1|uniprotkb:E9PQ97|uniprotkb:O60498|ensembl:ENSP00000359073	psi-mi:p85a_human(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)	psi-mi:vav3_human(display_long)|uniprotkb:VAV3(gene name)|psi-mi:VAV3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hartman et al. (2006)	pubmed:16982329|mint:MINT-7033842|doi:10.1016/j.exphem.2006.05.019	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6981153|mint:MINT-7103597	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001229395.1|refseq:NP_852556.2|refseq:NP_852664.1|refseq:NP_852665.1|ensembl:ENSG00000145675(gene)|ensembl:ENST00000521381(transcript)|ensembl:ENST00000521657(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENST00000320694|ensembl:ENSP00000323512|ensembl:ENST00000336483|ensembl:ENSP00000338554|ensembl:ENSP00000428056|ensembl:ENSP00000429277|ensembl:ENST00000523872|ensembl:ENSP00000430098|rcsb pdb:5SXA|rcsb pdb:5SXB|rcsb pdb:5SXC|rcsb pdb:5SXD|rcsb pdb:5SXE|rcsb pdb:5SXF|rcsb pdb:5SXI|rcsb pdb:5SXJ|rcsb pdb:5SXK|rcsb pdb:5UBT|rcsb pdb:5UK8|rcsb pdb:5UKJ|rcsb pdb:5SX9|rcsb pdb:5UL1|rcsb pdb:5VLR|rcsb pdb:5XGH|rcsb pdb:5XGI|rcsb pdb:5XGJ|rcsb pdb:6NCT|rcsb pdb:6PYR|rcsb pdb:6PYU|reactome:R-HSA-1660499|rcsb pdb:7CIO|rcsb pdb:7LM2|reactome:R-HSA-180292|reactome:R-HSA-109704|reactome:R-HSA-1839117|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1236382|reactome:R-HSA-186763|reactome:R-HSA-1963642|reactome:R-HSA-1250342|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-1433557|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-430116|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9603381|reactome:R-HSA-9607240|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-5655291|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9027276|reactome:R-HSA-9028335|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P27986|rcsb pdb:1A0N|rcsb pdb:1AZG|rcsb pdb:1H9O|rcsb pdb:1PBW|rcsb pdb:1PHT|rcsb pdb:1PIC|rcsb pdb:1PKS|rcsb pdb:1PKT|rcsb pdb:2IUG|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|rcsb pdb:2IUH|rcsb pdb:2IUI|rcsb pdb:2RD0|rcsb pdb:3HHM|rcsb pdb:3HIZ|rcsb pdb:3I5R|rcsb pdb:3I5S|rcsb pdb:4A55|rcsb pdb:4JPS|rcsb pdb:4L1B|rcsb pdb:4L23|rcsb pdb:4L2Y|rcsb pdb:4OVU|rcsb pdb:4OVV|rcsb pdb:4WAF|rcsb pdb:4YKN|rcsb pdb:4ZOP|rcsb pdb:5AUL|rcsb pdb:5FI4|rcsb pdb:5GJI|rcsb pdb:5ITD|rcsb pdb:5M6U|rcsb pdb:5SW8|rcsb pdb:5SWG|rcsb pdb:5SWO|rcsb pdb:2V1Y|rcsb pdb:5SWP|rcsb pdb:5SWR|rcsb pdb:5SWT|rcsb pdb:5SX8|refseq:XP_016865074.1|refseq:XP_005248599.1|dip:DIP-119N|mint:MINT-7103601(identity)	refseq:NP_001073343.1|refseq:NP_006104.4|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003096(SM22/calponin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR035734|interpro:IPR035881|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:Q9UKW4|rcsb pdb:2D86|reactome:R-HSA-114604|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9664422|ensembl:ENSG00000134215(gene)|ensembl:ENST00000370056(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001772"(immunological synapse)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0006906"(vesicle fusion)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042493"|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046872"(metal ion binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|refseq:XP_005270417.1|mint:MINT-7103599(identity)	-	-	-	figure legend:f3c|comment:homomint|comment:mint|curation depth:mimix curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2009/05/25	2014/10/16	rogid:pANLtVCSWVr64OXaS6bCjGBwfig9606	rogid:sCvtyb/upL3UweAEXaHjZEkKH6M9606	intact-crc:4C419F1120ABC66C|rigid:nMpslVY0KFA5B8/vbBltAuweDXU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P22681	uniprotkb:P45983	intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033	intact:EBI-286483|uniprotkb:Q15709|uniprotkb:Q15712|uniprotkb:Q15713|uniprotkb:B7ZLV4|uniprotkb:B5BTZ5|uniprotkb:Q308M2|uniprotkb:D3DX88|uniprotkb:D3DX92|ensembl:ENSP00000363304	psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym)	psi-mi:mk08_human(display_long)|uniprotkb:MAPK8(gene name)|psi-mi:MAPK8(display_short)|uniprotkb:JNK1(gene name synonym)|uniprotkb:PRKM8(gene name synonym)|uniprotkb:Stress-activated protein kinase JNK1(gene name synonym)|uniprotkb:c-Jun N-terminal kinase 1(gene name synonym)|uniprotkb:JNK-46(gene name synonym)|uniprotkb:SAPK1(gene name synonym)|uniprotkb:Stress-activated protein kinase 1c(gene name synonym)|uniprotkb:SAPK1C(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hartman et al. (2006)	pubmed:16982329|mint:MINT-7033842|doi:10.1016/j.exphem.2006.05.019	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6981204|mint:MINT-7103623	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377|mint:MINT-7103625(identity)	refseq:NP_620634.1|refseq:NP_620637.1|refseq:NP_001310231.1|refseq:NP_001310250.1|refseq:NP_001310251.1|refseq:NP_001310252.1|refseq:NP_001310253.1|refseq:NP_001310254.1|refseq:NP_001310255.1|refseq:NP_001310256.1|refseq:NP_001310257.1|refseq:NP_001310258.1|refseq:NP_001310259.1|refseq:NP_001310260.1|refseq:NP_001265476.1|refseq:NP_001265477.1|dip:DIP-249N|ensembl:ENSG00000107643(gene)|ensembl:ENST00000374189(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004705"(JUN kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007254"(JNK cascade)|go:"GO:0007258"(JUN phosphorylation)|go:"GO:0009411"(response to UV)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031343"(positive regulation of cell killing)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0048511"(rhythmic process)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090045"(positive regulation of deacetylase activity)|go:"GO:0090398"(cellular senescence)|go:"GO:0097441"(basal dendrite)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900740"(positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|go:"GO:1902595"(regulation of DNA replication origin binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008351(JNK MAP kinase)|interpro:IPR011009(Protein kinase-like)|mint:P45983|rcsb pdb:1UKH|rcsb pdb:1UKI|rcsb pdb:2G01|rcsb pdb:2GMX|rcsb pdb:2H96|rcsb pdb:2NO3|rcsb pdb:2XRW|rcsb pdb:2XS0|rcsb pdb:3ELJ|rcsb pdb:3O17|rcsb pdb:3O2M|rcsb pdb:3PZE|rcsb pdb:3V3V|rcsb pdb:3VUD|rcsb pdb:3VUG|rcsb pdb:3VUH|rcsb pdb:3VUI|rcsb pdb:3VUK|rcsb pdb:3VUL|rcsb pdb:3VUM|rcsb pdb:4AWI|rcsb pdb:4E73|rcsb pdb:4G1W|rcsb pdb:4HYS|rcsb pdb:4HYU|rcsb pdb:4IZY|rcsb pdb:4L7F|rcsb pdb:4QTD|rcsb pdb:4UX9|rcsb pdb:4YR8|rcsb pdb:5LW1|rcsb pdb:6F5E|rcsb pdb:6ZR5|reactome:R-HSA-111446|reactome:R-HSA-139910|reactome:R-HSA-193648|reactome:R-HSA-205043|reactome:R-HSA-2559580|reactome:R-HSA-2871796|reactome:R-HSA-376172|reactome:R-HSA-450321|reactome:R-HSA-450341|reactome:R-HSA-5693565|reactome:R-HSA-9007892|reactome:R-HSA-9673324|mint:MINT-7103627(identity)	-	-	-	figure legend:f3g|comment:homomint|comment:mint|curation depth:mimix curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2009/05/25	2014/10/16	rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606	rogid:8FsGgIJWzsgWymaBqL5+0eQ/7qM9606	intact-crc:FB88922B5901C474|rigid:9QXskbY42KtGcLauQz6Fu0ya5rw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P22681	uniprotkb:P27986	intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033	intact:EBI-79464|intact:EBI-28974553|ensembl:ENSP00000428056|ensembl:ENSP00000429277|uniprotkb:Q15747|uniprotkb:Q4VBZ7|uniprotkb:Q53EM6|uniprotkb:Q8IXA2|uniprotkb:Q8N1C5|uniprotkb:D3DWA0|uniprotkb:B3KT19|uniprotkb:E7EX19	psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym)	psi-mi:p85a_human(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hartman et al. (2006)	pubmed:16982329|mint:MINT-7033842|doi:10.1016/j.exphem.2006.05.019	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6981165|mint:MINT-7103607	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377|mint:MINT-7103609(identity)	refseq:NP_001229395.1|refseq:NP_852556.2|refseq:NP_852664.1|refseq:NP_852665.1|ensembl:ENSG00000145675(gene)|ensembl:ENST00000521381(transcript)|ensembl:ENST00000521657(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENST00000320694|ensembl:ENSP00000323512|ensembl:ENST00000336483|ensembl:ENSP00000338554|ensembl:ENSP00000428056|ensembl:ENSP00000429277|ensembl:ENST00000523872|ensembl:ENSP00000430098|rcsb pdb:5SXA|rcsb pdb:5SXB|rcsb pdb:5SXC|rcsb pdb:5SXD|rcsb pdb:5SXE|rcsb pdb:5SXF|rcsb pdb:5SXI|rcsb pdb:5SXJ|rcsb pdb:5SXK|rcsb pdb:5UBT|rcsb pdb:5UK8|rcsb pdb:5UKJ|rcsb pdb:5SX9|rcsb pdb:5UL1|rcsb pdb:5VLR|rcsb pdb:5XGH|rcsb pdb:5XGI|rcsb pdb:5XGJ|rcsb pdb:6NCT|rcsb pdb:6PYR|rcsb pdb:6PYU|reactome:R-HSA-1660499|rcsb pdb:7CIO|rcsb pdb:7LM2|reactome:R-HSA-180292|reactome:R-HSA-109704|reactome:R-HSA-1839117|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1236382|reactome:R-HSA-186763|reactome:R-HSA-1963642|reactome:R-HSA-1250342|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-1433557|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-430116|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9603381|reactome:R-HSA-9607240|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-5655291|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9027276|reactome:R-HSA-9028335|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P27986|rcsb pdb:1A0N|rcsb pdb:1AZG|rcsb pdb:1H9O|rcsb pdb:1PBW|rcsb pdb:1PHT|rcsb pdb:1PIC|rcsb pdb:1PKS|rcsb pdb:1PKT|rcsb pdb:2IUG|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|rcsb pdb:2IUH|rcsb pdb:2IUI|rcsb pdb:2RD0|rcsb pdb:3HHM|rcsb pdb:3HIZ|rcsb pdb:3I5R|rcsb pdb:3I5S|rcsb pdb:4A55|rcsb pdb:4JPS|rcsb pdb:4L1B|rcsb pdb:4L23|rcsb pdb:4L2Y|rcsb pdb:4OVU|rcsb pdb:4OVV|rcsb pdb:4WAF|rcsb pdb:4YKN|rcsb pdb:4ZOP|rcsb pdb:5AUL|rcsb pdb:5FI4|rcsb pdb:5GJI|rcsb pdb:5ITD|rcsb pdb:5M6U|rcsb pdb:5SW8|rcsb pdb:5SWG|rcsb pdb:5SWO|rcsb pdb:2V1Y|rcsb pdb:5SWP|rcsb pdb:5SWR|rcsb pdb:5SWT|rcsb pdb:5SX8|refseq:XP_016865074.1|refseq:XP_005248599.1|dip:DIP-119N|mint:MINT-7103680(identity)	-	-	-	figure legend:f3g|comment:homomint|comment:mint|curation depth:mimix curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2009/05/25	2014/10/16	rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606	rogid:pANLtVCSWVr64OXaS6bCjGBwfig9606	intact-crc:BA6160560394C9E3|rigid:rxRfg3ZafGPhM7h/oaaF+qZ3Gdk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P45983	uniprotkb:P27986	intact:EBI-286483|uniprotkb:Q15709|uniprotkb:Q15712|uniprotkb:Q15713|uniprotkb:B7ZLV4|uniprotkb:B5BTZ5|uniprotkb:Q308M2|uniprotkb:D3DX88|uniprotkb:D3DX92|ensembl:ENSP00000363304	intact:EBI-79464|intact:EBI-28974553|ensembl:ENSP00000428056|ensembl:ENSP00000429277|uniprotkb:Q15747|uniprotkb:Q4VBZ7|uniprotkb:Q53EM6|uniprotkb:Q8IXA2|uniprotkb:Q8N1C5|uniprotkb:D3DWA0|uniprotkb:B3KT19|uniprotkb:E7EX19	psi-mi:mk08_human(display_long)|uniprotkb:MAPK8(gene name)|psi-mi:MAPK8(display_short)|uniprotkb:JNK1(gene name synonym)|uniprotkb:PRKM8(gene name synonym)|uniprotkb:Stress-activated protein kinase JNK1(gene name synonym)|uniprotkb:c-Jun N-terminal kinase 1(gene name synonym)|uniprotkb:JNK-46(gene name synonym)|uniprotkb:SAPK1(gene name synonym)|uniprotkb:Stress-activated protein kinase 1c(gene name synonym)|uniprotkb:SAPK1C(gene name synonym)	psi-mi:p85a_human(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hartman et al. (2006)	pubmed:16982329|mint:MINT-7033842|doi:10.1016/j.exphem.2006.05.019	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6981177|mint:MINT-7103616	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_620634.1|refseq:NP_620637.1|refseq:NP_001310231.1|refseq:NP_001310250.1|refseq:NP_001310251.1|refseq:NP_001310252.1|refseq:NP_001310253.1|refseq:NP_001310254.1|refseq:NP_001310255.1|refseq:NP_001310256.1|refseq:NP_001310257.1|refseq:NP_001310258.1|refseq:NP_001310259.1|refseq:NP_001310260.1|refseq:NP_001265476.1|refseq:NP_001265477.1|dip:DIP-249N|ensembl:ENSG00000107643(gene)|ensembl:ENST00000374189(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004705"(JUN kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007254"(JNK cascade)|go:"GO:0007258"(JUN phosphorylation)|go:"GO:0009411"(response to UV)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031343"(positive regulation of cell killing)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0048511"(rhythmic process)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090045"(positive regulation of deacetylase activity)|go:"GO:0090398"(cellular senescence)|go:"GO:0097441"(basal dendrite)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900740"(positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|go:"GO:1902595"(regulation of DNA replication origin binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008351(JNK MAP kinase)|interpro:IPR011009(Protein kinase-like)|mint:P45983|rcsb pdb:1UKH|rcsb pdb:1UKI|rcsb pdb:2G01|rcsb pdb:2GMX|rcsb pdb:2H96|rcsb pdb:2NO3|rcsb pdb:2XRW|rcsb pdb:2XS0|rcsb pdb:3ELJ|rcsb pdb:3O17|rcsb pdb:3O2M|rcsb pdb:3PZE|rcsb pdb:3V3V|rcsb pdb:3VUD|rcsb pdb:3VUG|rcsb pdb:3VUH|rcsb pdb:3VUI|rcsb pdb:3VUK|rcsb pdb:3VUL|rcsb pdb:3VUM|rcsb pdb:4AWI|rcsb pdb:4E73|rcsb pdb:4G1W|rcsb pdb:4HYS|rcsb pdb:4HYU|rcsb pdb:4IZY|rcsb pdb:4L7F|rcsb pdb:4QTD|rcsb pdb:4UX9|rcsb pdb:4YR8|rcsb pdb:5LW1|rcsb pdb:6F5E|rcsb pdb:6ZR5|reactome:R-HSA-111446|reactome:R-HSA-139910|reactome:R-HSA-193648|reactome:R-HSA-205043|reactome:R-HSA-2559580|reactome:R-HSA-2871796|reactome:R-HSA-376172|reactome:R-HSA-450321|reactome:R-HSA-450341|reactome:R-HSA-5693565|reactome:R-HSA-9007892|reactome:R-HSA-9673324|mint:MINT-7103618(identity)	refseq:NP_001229395.1|refseq:NP_852556.2|refseq:NP_852664.1|refseq:NP_852665.1|ensembl:ENSG00000145675(gene)|ensembl:ENST00000521381(transcript)|ensembl:ENST00000521657(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENST00000320694|ensembl:ENSP00000323512|ensembl:ENST00000336483|ensembl:ENSP00000338554|ensembl:ENSP00000428056|ensembl:ENSP00000429277|ensembl:ENST00000523872|ensembl:ENSP00000430098|rcsb pdb:5SXA|rcsb pdb:5SXB|rcsb pdb:5SXC|rcsb pdb:5SXD|rcsb pdb:5SXE|rcsb pdb:5SXF|rcsb pdb:5SXI|rcsb pdb:5SXJ|rcsb pdb:5SXK|rcsb pdb:5UBT|rcsb pdb:5UK8|rcsb pdb:5UKJ|rcsb pdb:5SX9|rcsb pdb:5UL1|rcsb pdb:5VLR|rcsb pdb:5XGH|rcsb pdb:5XGI|rcsb pdb:5XGJ|rcsb pdb:6NCT|rcsb pdb:6PYR|rcsb pdb:6PYU|reactome:R-HSA-1660499|rcsb pdb:7CIO|rcsb pdb:7LM2|reactome:R-HSA-180292|reactome:R-HSA-109704|reactome:R-HSA-1839117|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1236382|reactome:R-HSA-186763|reactome:R-HSA-1963642|reactome:R-HSA-1250342|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-1433557|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-430116|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9603381|reactome:R-HSA-9607240|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-5655291|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9027276|reactome:R-HSA-9028335|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P27986|rcsb pdb:1A0N|rcsb pdb:1AZG|rcsb pdb:1H9O|rcsb pdb:1PBW|rcsb pdb:1PHT|rcsb pdb:1PIC|rcsb pdb:1PKS|rcsb pdb:1PKT|rcsb pdb:2IUG|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|rcsb pdb:2IUH|rcsb pdb:2IUI|rcsb pdb:2RD0|rcsb pdb:3HHM|rcsb pdb:3HIZ|rcsb pdb:3I5R|rcsb pdb:3I5S|rcsb pdb:4A55|rcsb pdb:4JPS|rcsb pdb:4L1B|rcsb pdb:4L23|rcsb pdb:4L2Y|rcsb pdb:4OVU|rcsb pdb:4OVV|rcsb pdb:4WAF|rcsb pdb:4YKN|rcsb pdb:4ZOP|rcsb pdb:5AUL|rcsb pdb:5FI4|rcsb pdb:5GJI|rcsb pdb:5ITD|rcsb pdb:5M6U|rcsb pdb:5SW8|rcsb pdb:5SWG|rcsb pdb:5SWO|rcsb pdb:2V1Y|rcsb pdb:5SWP|rcsb pdb:5SWR|rcsb pdb:5SWT|rcsb pdb:5SX8|refseq:XP_016865074.1|refseq:XP_005248599.1|dip:DIP-119N|mint:MINT-7103635(identity)	-	-	-	comment:homomint|comment:mint|figure legend:f3h|curation depth:mimix curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2009/05/25	2014/10/16	rogid:8FsGgIJWzsgWymaBqL5+0eQ/7qM9606	rogid:pANLtVCSWVr64OXaS6bCjGBwfig9606	intact-crc:ED0CE1F415ED9241|rigid:VyELY1TWCjkyA8PFIxRshO8oXaM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46109	uniprotkb:P27986	intact:EBI-910|uniprotkb:A8KA44|intact:EBI-3451075|uniprotkb:D3DX35|ensembl:ENSP00000346300|ensembl:ENSP00000396646	intact:EBI-79464|intact:EBI-28974553|ensembl:ENSP00000428056|ensembl:ENSP00000429277|uniprotkb:Q15747|uniprotkb:Q4VBZ7|uniprotkb:Q53EM6|uniprotkb:Q8IXA2|uniprotkb:Q8N1C5|uniprotkb:D3DWA0|uniprotkb:B3KT19|uniprotkb:E7EX19	psi-mi:crkl_human(display_long)|uniprotkb:CRKL(gene name)|psi-mi:CRKL(display_short)	psi-mi:p85a_human(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hartman et al. (2006)	pubmed:16982329|mint:MINT-7033842|doi:10.1016/j.exphem.2006.05.019	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6981240|mint:MINT-7103655	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005198.1|dip:DIP-29165N|ensembl:ENSG00000099942(gene)|ensembl:ENST00000354336(transcript)|ensembl:ENST00000411769(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001568"(blood vessel development)|go:"GO:0001655"(urogenital system development)|go:"GO:0001764"(neuron migration)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007254"(JNK cascade)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007416"(synapse assembly)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0008584"(male gonad development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016358"(dendrite development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035690"|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060465"(pharynx development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903977"(positive regulation of glial cell migration)|go:"GO:1904393"(regulation of skeletal muscle acetylcholine-gated channel clustering)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46109|rcsb pdb:2BZX|rcsb pdb:2BZY|rcsb pdb:2DBK|rcsb pdb:2EO3|rcsb pdb:2LQN|rcsb pdb:2LQW|reactome:R-HSA-170968|reactome:R-HSA-186763|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-9027284|reactome:R-HSA-912631|mint:MINT-7103663(identity)	refseq:NP_001229395.1|refseq:NP_852556.2|refseq:NP_852664.1|refseq:NP_852665.1|ensembl:ENSG00000145675(gene)|ensembl:ENST00000521381(transcript)|ensembl:ENST00000521657(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENST00000320694|ensembl:ENSP00000323512|ensembl:ENST00000336483|ensembl:ENSP00000338554|ensembl:ENSP00000428056|ensembl:ENSP00000429277|ensembl:ENST00000523872|ensembl:ENSP00000430098|rcsb pdb:5SXA|rcsb pdb:5SXB|rcsb pdb:5SXC|rcsb pdb:5SXD|rcsb pdb:5SXE|rcsb pdb:5SXF|rcsb pdb:5SXI|rcsb pdb:5SXJ|rcsb pdb:5SXK|rcsb pdb:5UBT|rcsb pdb:5UK8|rcsb pdb:5UKJ|rcsb pdb:5SX9|rcsb pdb:5UL1|rcsb pdb:5VLR|rcsb pdb:5XGH|rcsb pdb:5XGI|rcsb pdb:5XGJ|rcsb pdb:6NCT|rcsb pdb:6PYR|rcsb pdb:6PYU|reactome:R-HSA-1660499|rcsb pdb:7CIO|rcsb pdb:7LM2|reactome:R-HSA-180292|reactome:R-HSA-109704|reactome:R-HSA-1839117|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1236382|reactome:R-HSA-186763|reactome:R-HSA-1963642|reactome:R-HSA-1250342|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-1433557|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-430116|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9603381|reactome:R-HSA-9607240|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-5655291|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9027276|reactome:R-HSA-9028335|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P27986|rcsb pdb:1A0N|rcsb pdb:1AZG|rcsb pdb:1H9O|rcsb pdb:1PBW|rcsb pdb:1PHT|rcsb pdb:1PIC|rcsb pdb:1PKS|rcsb pdb:1PKT|rcsb pdb:2IUG|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|rcsb pdb:2IUH|rcsb pdb:2IUI|rcsb pdb:2RD0|rcsb pdb:3HHM|rcsb pdb:3HIZ|rcsb pdb:3I5R|rcsb pdb:3I5S|rcsb pdb:4A55|rcsb pdb:4JPS|rcsb pdb:4L1B|rcsb pdb:4L23|rcsb pdb:4L2Y|rcsb pdb:4OVU|rcsb pdb:4OVV|rcsb pdb:4WAF|rcsb pdb:4YKN|rcsb pdb:4ZOP|rcsb pdb:5AUL|rcsb pdb:5FI4|rcsb pdb:5GJI|rcsb pdb:5ITD|rcsb pdb:5M6U|rcsb pdb:5SW8|rcsb pdb:5SWG|rcsb pdb:5SWO|rcsb pdb:2V1Y|rcsb pdb:5SWP|rcsb pdb:5SWR|rcsb pdb:5SWT|rcsb pdb:5SX8|refseq:XP_016865074.1|refseq:XP_005248599.1|dip:DIP-119N|mint:MINT-7103674(identity)	-	-	-	comment:homomint|comment:mint|figure legend:f3h|curation depth:mimix curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2009/05/25	2014/10/16	rogid:1YwlbUPPuijisz7AJM4Qkp7yJBI9606	rogid:pANLtVCSWVr64OXaS6bCjGBwfig9606	intact-crc:9A2BCAA982193B6F|rigid:YEN4Wfm1ztEI5nMWYg7vT3ZQ2ac	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P45983	uniprotkb:P27986	intact:EBI-286483|uniprotkb:Q15709|uniprotkb:Q15712|uniprotkb:Q15713|uniprotkb:B7ZLV4|uniprotkb:B5BTZ5|uniprotkb:Q308M2|uniprotkb:D3DX88|uniprotkb:D3DX92|ensembl:ENSP00000363304	intact:EBI-79464|intact:EBI-28974553|ensembl:ENSP00000428056|ensembl:ENSP00000429277|uniprotkb:Q15747|uniprotkb:Q4VBZ7|uniprotkb:Q53EM6|uniprotkb:Q8IXA2|uniprotkb:Q8N1C5|uniprotkb:D3DWA0|uniprotkb:B3KT19|uniprotkb:E7EX19	psi-mi:mk08_human(display_long)|uniprotkb:MAPK8(gene name)|psi-mi:MAPK8(display_short)|uniprotkb:JNK1(gene name synonym)|uniprotkb:PRKM8(gene name synonym)|uniprotkb:Stress-activated protein kinase JNK1(gene name synonym)|uniprotkb:c-Jun N-terminal kinase 1(gene name synonym)|uniprotkb:JNK-46(gene name synonym)|uniprotkb:SAPK1(gene name synonym)|uniprotkb:Stress-activated protein kinase 1c(gene name synonym)|uniprotkb:SAPK1C(gene name synonym)	psi-mi:p85a_human(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hartman et al. (2006)	pubmed:16982329|mint:MINT-7033842|doi:10.1016/j.exphem.2006.05.019	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6981216|mint:MINT-7103638	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_620634.1|refseq:NP_620637.1|refseq:NP_001310231.1|refseq:NP_001310250.1|refseq:NP_001310251.1|refseq:NP_001310252.1|refseq:NP_001310253.1|refseq:NP_001310254.1|refseq:NP_001310255.1|refseq:NP_001310256.1|refseq:NP_001310257.1|refseq:NP_001310258.1|refseq:NP_001310259.1|refseq:NP_001310260.1|refseq:NP_001265476.1|refseq:NP_001265477.1|dip:DIP-249N|ensembl:ENSG00000107643(gene)|ensembl:ENST00000374189(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004705"(JUN kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007254"(JNK cascade)|go:"GO:0007258"(JUN phosphorylation)|go:"GO:0009411"(response to UV)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031343"(positive regulation of cell killing)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0048511"(rhythmic process)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090045"(positive regulation of deacetylase activity)|go:"GO:0090398"(cellular senescence)|go:"GO:0097441"(basal dendrite)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900740"(positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|go:"GO:1902595"(regulation of DNA replication origin binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008351(JNK MAP kinase)|interpro:IPR011009(Protein kinase-like)|mint:P45983|rcsb pdb:1UKH|rcsb pdb:1UKI|rcsb pdb:2G01|rcsb pdb:2GMX|rcsb pdb:2H96|rcsb pdb:2NO3|rcsb pdb:2XRW|rcsb pdb:2XS0|rcsb pdb:3ELJ|rcsb pdb:3O17|rcsb pdb:3O2M|rcsb pdb:3PZE|rcsb pdb:3V3V|rcsb pdb:3VUD|rcsb pdb:3VUG|rcsb pdb:3VUH|rcsb pdb:3VUI|rcsb pdb:3VUK|rcsb pdb:3VUL|rcsb pdb:3VUM|rcsb pdb:4AWI|rcsb pdb:4E73|rcsb pdb:4G1W|rcsb pdb:4HYS|rcsb pdb:4HYU|rcsb pdb:4IZY|rcsb pdb:4L7F|rcsb pdb:4QTD|rcsb pdb:4UX9|rcsb pdb:4YR8|rcsb pdb:5LW1|rcsb pdb:6F5E|rcsb pdb:6ZR5|reactome:R-HSA-111446|reactome:R-HSA-139910|reactome:R-HSA-193648|reactome:R-HSA-205043|reactome:R-HSA-2559580|reactome:R-HSA-2871796|reactome:R-HSA-376172|reactome:R-HSA-450321|reactome:R-HSA-450341|reactome:R-HSA-5693565|reactome:R-HSA-9007892|reactome:R-HSA-9673324|mint:MINT-7103642(identity)	refseq:NP_001229395.1|refseq:NP_852556.2|refseq:NP_852664.1|refseq:NP_852665.1|ensembl:ENSG00000145675(gene)|ensembl:ENST00000521381(transcript)|ensembl:ENST00000521657(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENST00000320694|ensembl:ENSP00000323512|ensembl:ENST00000336483|ensembl:ENSP00000338554|ensembl:ENSP00000428056|ensembl:ENSP00000429277|ensembl:ENST00000523872|ensembl:ENSP00000430098|rcsb pdb:5SXA|rcsb pdb:5SXB|rcsb pdb:5SXC|rcsb pdb:5SXD|rcsb pdb:5SXE|rcsb pdb:5SXF|rcsb pdb:5SXI|rcsb pdb:5SXJ|rcsb pdb:5SXK|rcsb pdb:5UBT|rcsb pdb:5UK8|rcsb pdb:5UKJ|rcsb pdb:5SX9|rcsb pdb:5UL1|rcsb pdb:5VLR|rcsb pdb:5XGH|rcsb pdb:5XGI|rcsb pdb:5XGJ|rcsb pdb:6NCT|rcsb pdb:6PYR|rcsb pdb:6PYU|reactome:R-HSA-1660499|rcsb pdb:7CIO|rcsb pdb:7LM2|reactome:R-HSA-180292|reactome:R-HSA-109704|reactome:R-HSA-1839117|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1236382|reactome:R-HSA-186763|reactome:R-HSA-1963642|reactome:R-HSA-1250342|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-1433557|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-430116|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9603381|reactome:R-HSA-9607240|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-5655291|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9027276|reactome:R-HSA-9028335|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P27986|rcsb pdb:1A0N|rcsb pdb:1AZG|rcsb pdb:1H9O|rcsb pdb:1PBW|rcsb pdb:1PHT|rcsb pdb:1PIC|rcsb pdb:1PKS|rcsb pdb:1PKT|rcsb pdb:2IUG|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|rcsb pdb:2IUH|rcsb pdb:2IUI|rcsb pdb:2RD0|rcsb pdb:3HHM|rcsb pdb:3HIZ|rcsb pdb:3I5R|rcsb pdb:3I5S|rcsb pdb:4A55|rcsb pdb:4JPS|rcsb pdb:4L1B|rcsb pdb:4L23|rcsb pdb:4L2Y|rcsb pdb:4OVU|rcsb pdb:4OVV|rcsb pdb:4WAF|rcsb pdb:4YKN|rcsb pdb:4ZOP|rcsb pdb:5AUL|rcsb pdb:5FI4|rcsb pdb:5GJI|rcsb pdb:5ITD|rcsb pdb:5M6U|rcsb pdb:5SW8|rcsb pdb:5SWG|rcsb pdb:5SWO|rcsb pdb:2V1Y|rcsb pdb:5SWP|rcsb pdb:5SWR|rcsb pdb:5SWT|rcsb pdb:5SX8|refseq:XP_016865074.1|refseq:XP_005248599.1|dip:DIP-119N|mint:MINT-7103640(identity)	-	-	-	figure legend:f3g|comment:homomint|comment:mint|curation depth:mimix curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2009/05/25	2014/10/16	rogid:8FsGgIJWzsgWymaBqL5+0eQ/7qM9606	rogid:pANLtVCSWVr64OXaS6bCjGBwfig9606	intact-crc:84E33D1C25DF9CF4|rigid:VyELY1TWCjkyA8PFIxRshO8oXaM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P45983	uniprotkb:P22681	intact:EBI-286483|uniprotkb:Q15709|uniprotkb:Q15712|uniprotkb:Q15713|uniprotkb:B7ZLV4|uniprotkb:B5BTZ5|uniprotkb:Q308M2|uniprotkb:D3DX88|uniprotkb:D3DX92|ensembl:ENSP00000363304	intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033	psi-mi:mk08_human(display_long)|uniprotkb:MAPK8(gene name)|psi-mi:MAPK8(display_short)|uniprotkb:JNK1(gene name synonym)|uniprotkb:PRKM8(gene name synonym)|uniprotkb:Stress-activated protein kinase JNK1(gene name synonym)|uniprotkb:c-Jun N-terminal kinase 1(gene name synonym)|uniprotkb:JNK-46(gene name synonym)|uniprotkb:SAPK1(gene name synonym)|uniprotkb:Stress-activated protein kinase 1c(gene name synonym)|uniprotkb:SAPK1C(gene name synonym)	psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hartman et al. (2006)	pubmed:16982329|mint:MINT-7033842|doi:10.1016/j.exphem.2006.05.019	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6981228|mint:MINT-7103648	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_620634.1|refseq:NP_620637.1|refseq:NP_001310231.1|refseq:NP_001310250.1|refseq:NP_001310251.1|refseq:NP_001310252.1|refseq:NP_001310253.1|refseq:NP_001310254.1|refseq:NP_001310255.1|refseq:NP_001310256.1|refseq:NP_001310257.1|refseq:NP_001310258.1|refseq:NP_001310259.1|refseq:NP_001310260.1|refseq:NP_001265476.1|refseq:NP_001265477.1|dip:DIP-249N|ensembl:ENSG00000107643(gene)|ensembl:ENST00000374189(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004705"(JUN kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007254"(JNK cascade)|go:"GO:0007258"(JUN phosphorylation)|go:"GO:0009411"(response to UV)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031343"(positive regulation of cell killing)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0048511"(rhythmic process)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090045"(positive regulation of deacetylase activity)|go:"GO:0090398"(cellular senescence)|go:"GO:0097441"(basal dendrite)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900740"(positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|go:"GO:1902595"(regulation of DNA replication origin binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008351(JNK MAP kinase)|interpro:IPR011009(Protein kinase-like)|mint:P45983|rcsb pdb:1UKH|rcsb pdb:1UKI|rcsb pdb:2G01|rcsb pdb:2GMX|rcsb pdb:2H96|rcsb pdb:2NO3|rcsb pdb:2XRW|rcsb pdb:2XS0|rcsb pdb:3ELJ|rcsb pdb:3O17|rcsb pdb:3O2M|rcsb pdb:3PZE|rcsb pdb:3V3V|rcsb pdb:3VUD|rcsb pdb:3VUG|rcsb pdb:3VUH|rcsb pdb:3VUI|rcsb pdb:3VUK|rcsb pdb:3VUL|rcsb pdb:3VUM|rcsb pdb:4AWI|rcsb pdb:4E73|rcsb pdb:4G1W|rcsb pdb:4HYS|rcsb pdb:4HYU|rcsb pdb:4IZY|rcsb pdb:4L7F|rcsb pdb:4QTD|rcsb pdb:4UX9|rcsb pdb:4YR8|rcsb pdb:5LW1|rcsb pdb:6F5E|rcsb pdb:6ZR5|reactome:R-HSA-111446|reactome:R-HSA-139910|reactome:R-HSA-193648|reactome:R-HSA-205043|reactome:R-HSA-2559580|reactome:R-HSA-2871796|reactome:R-HSA-376172|reactome:R-HSA-450321|reactome:R-HSA-450341|reactome:R-HSA-5693565|reactome:R-HSA-9007892|reactome:R-HSA-9673324|mint:MINT-7103650(identity)	refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377|mint:MINT-7103652(identity)	-	-	-	comment:homomint|comment:mint|figure legend:f3h|curation depth:mimix curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2009/05/25	2014/10/16	rogid:8FsGgIJWzsgWymaBqL5+0eQ/7qM9606	rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606	intact-crc:7BD1EB556F13CD77|rigid:9QXskbY42KtGcLauQz6Fu0ya5rw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P27986	uniprotkb:P22681	intact:EBI-79464|intact:EBI-28974553|ensembl:ENSP00000428056|ensembl:ENSP00000429277|uniprotkb:Q15747|uniprotkb:Q4VBZ7|uniprotkb:Q53EM6|uniprotkb:Q8IXA2|uniprotkb:Q8N1C5|uniprotkb:D3DWA0|uniprotkb:B3KT19|uniprotkb:E7EX19	intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033	psi-mi:p85a_human(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)	psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hartman et al. (2006)	pubmed:16982329|mint:MINT-7033842|doi:10.1016/j.exphem.2006.05.019	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6981264|mint:MINT-7103683	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001229395.1|refseq:NP_852556.2|refseq:NP_852664.1|refseq:NP_852665.1|ensembl:ENSG00000145675(gene)|ensembl:ENST00000521381(transcript)|ensembl:ENST00000521657(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENST00000320694|ensembl:ENSP00000323512|ensembl:ENST00000336483|ensembl:ENSP00000338554|ensembl:ENSP00000428056|ensembl:ENSP00000429277|ensembl:ENST00000523872|ensembl:ENSP00000430098|rcsb pdb:5SXA|rcsb pdb:5SXB|rcsb pdb:5SXC|rcsb pdb:5SXD|rcsb pdb:5SXE|rcsb pdb:5SXF|rcsb pdb:5SXI|rcsb pdb:5SXJ|rcsb pdb:5SXK|rcsb pdb:5UBT|rcsb pdb:5UK8|rcsb pdb:5UKJ|rcsb pdb:5SX9|rcsb pdb:5UL1|rcsb pdb:5VLR|rcsb pdb:5XGH|rcsb pdb:5XGI|rcsb pdb:5XGJ|rcsb pdb:6NCT|rcsb pdb:6PYR|rcsb pdb:6PYU|reactome:R-HSA-1660499|rcsb pdb:7CIO|rcsb pdb:7LM2|reactome:R-HSA-180292|reactome:R-HSA-109704|reactome:R-HSA-1839117|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1236382|reactome:R-HSA-186763|reactome:R-HSA-1963642|reactome:R-HSA-1250342|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-1433557|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-430116|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9603381|reactome:R-HSA-9607240|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-5655291|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9027276|reactome:R-HSA-9028335|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P27986|rcsb pdb:1A0N|rcsb pdb:1AZG|rcsb pdb:1H9O|rcsb pdb:1PBW|rcsb pdb:1PHT|rcsb pdb:1PIC|rcsb pdb:1PKS|rcsb pdb:1PKT|rcsb pdb:2IUG|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|rcsb pdb:2IUH|rcsb pdb:2IUI|rcsb pdb:2RD0|rcsb pdb:3HHM|rcsb pdb:3HIZ|rcsb pdb:3I5R|rcsb pdb:3I5S|rcsb pdb:4A55|rcsb pdb:4JPS|rcsb pdb:4L1B|rcsb pdb:4L23|rcsb pdb:4L2Y|rcsb pdb:4OVU|rcsb pdb:4OVV|rcsb pdb:4WAF|rcsb pdb:4YKN|rcsb pdb:4ZOP|rcsb pdb:5AUL|rcsb pdb:5FI4|rcsb pdb:5GJI|rcsb pdb:5ITD|rcsb pdb:5M6U|rcsb pdb:5SW8|rcsb pdb:5SWG|rcsb pdb:5SWO|rcsb pdb:2V1Y|rcsb pdb:5SWP|rcsb pdb:5SWR|rcsb pdb:5SWT|rcsb pdb:5SX8|refseq:XP_016865074.1|refseq:XP_005248599.1|dip:DIP-119N|mint:MINT-7103685(identity)	refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377|mint:MINT-7103687(identity)	-	-	-	figure legend:f3g|comment:homomint|comment:mint|curation depth:mimix curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2009/05/25	2014/10/16	rogid:pANLtVCSWVr64OXaS6bCjGBwfig9606	rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606	intact-crc:655EBCBE33AAFBA5|rigid:rxRfg3ZafGPhM7h/oaaF+qZ3Gdk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46109	uniprotkb:P45983	intact:EBI-910|uniprotkb:A8KA44|intact:EBI-3451075|uniprotkb:D3DX35|ensembl:ENSP00000346300|ensembl:ENSP00000396646	intact:EBI-286483|uniprotkb:Q15709|uniprotkb:Q15712|uniprotkb:Q15713|uniprotkb:B7ZLV4|uniprotkb:B5BTZ5|uniprotkb:Q308M2|uniprotkb:D3DX88|uniprotkb:D3DX92|ensembl:ENSP00000363304	psi-mi:crkl_human(display_long)|uniprotkb:CRKL(gene name)|psi-mi:CRKL(display_short)	psi-mi:mk08_human(display_long)|uniprotkb:MAPK8(gene name)|psi-mi:MAPK8(display_short)|uniprotkb:JNK1(gene name synonym)|uniprotkb:PRKM8(gene name synonym)|uniprotkb:Stress-activated protein kinase JNK1(gene name synonym)|uniprotkb:c-Jun N-terminal kinase 1(gene name synonym)|uniprotkb:JNK-46(gene name synonym)|uniprotkb:SAPK1(gene name synonym)|uniprotkb:Stress-activated protein kinase 1c(gene name synonym)|uniprotkb:SAPK1C(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hartman et al. (2006)	pubmed:16982329|mint:MINT-7033842|doi:10.1016/j.exphem.2006.05.019	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6981276|mint:MINT-7103692	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005198.1|dip:DIP-29165N|ensembl:ENSG00000099942(gene)|ensembl:ENST00000354336(transcript)|ensembl:ENST00000411769(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001568"(blood vessel development)|go:"GO:0001655"(urogenital system development)|go:"GO:0001764"(neuron migration)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007254"(JNK cascade)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007416"(synapse assembly)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0008584"(male gonad development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016358"(dendrite development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035690"|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060465"(pharynx development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903977"(positive regulation of glial cell migration)|go:"GO:1904393"(regulation of skeletal muscle acetylcholine-gated channel clustering)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46109|rcsb pdb:2BZX|rcsb pdb:2BZY|rcsb pdb:2DBK|rcsb pdb:2EO3|rcsb pdb:2LQN|rcsb pdb:2LQW|reactome:R-HSA-170968|reactome:R-HSA-186763|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-9027284|reactome:R-HSA-912631|mint:MINT-7103700(identity)	refseq:NP_620634.1|refseq:NP_620637.1|refseq:NP_001310231.1|refseq:NP_001310250.1|refseq:NP_001310251.1|refseq:NP_001310252.1|refseq:NP_001310253.1|refseq:NP_001310254.1|refseq:NP_001310255.1|refseq:NP_001310256.1|refseq:NP_001310257.1|refseq:NP_001310258.1|refseq:NP_001310259.1|refseq:NP_001310260.1|refseq:NP_001265476.1|refseq:NP_001265477.1|dip:DIP-249N|ensembl:ENSG00000107643(gene)|ensembl:ENST00000374189(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004705"(JUN kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007254"(JNK cascade)|go:"GO:0007258"(JUN phosphorylation)|go:"GO:0009411"(response to UV)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031343"(positive regulation of cell killing)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0048511"(rhythmic process)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090045"(positive regulation of deacetylase activity)|go:"GO:0090398"(cellular senescence)|go:"GO:0097441"(basal dendrite)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900740"(positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|go:"GO:1902595"(regulation of DNA replication origin binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008351(JNK MAP kinase)|interpro:IPR011009(Protein kinase-like)|mint:P45983|rcsb pdb:1UKH|rcsb pdb:1UKI|rcsb pdb:2G01|rcsb pdb:2GMX|rcsb pdb:2H96|rcsb pdb:2NO3|rcsb pdb:2XRW|rcsb pdb:2XS0|rcsb pdb:3ELJ|rcsb pdb:3O17|rcsb pdb:3O2M|rcsb pdb:3PZE|rcsb pdb:3V3V|rcsb pdb:3VUD|rcsb pdb:3VUG|rcsb pdb:3VUH|rcsb pdb:3VUI|rcsb pdb:3VUK|rcsb pdb:3VUL|rcsb pdb:3VUM|rcsb pdb:4AWI|rcsb pdb:4E73|rcsb pdb:4G1W|rcsb pdb:4HYS|rcsb pdb:4HYU|rcsb pdb:4IZY|rcsb pdb:4L7F|rcsb pdb:4QTD|rcsb pdb:4UX9|rcsb pdb:4YR8|rcsb pdb:5LW1|rcsb pdb:6F5E|rcsb pdb:6ZR5|reactome:R-HSA-111446|reactome:R-HSA-139910|reactome:R-HSA-193648|reactome:R-HSA-205043|reactome:R-HSA-2559580|reactome:R-HSA-2871796|reactome:R-HSA-376172|reactome:R-HSA-450321|reactome:R-HSA-450341|reactome:R-HSA-5693565|reactome:R-HSA-9007892|reactome:R-HSA-9673324|mint:MINT-7103696(identity)	-	-	-	comment:homomint|comment:mint|figure legend:f3h|curation depth:mimix curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2009/05/25	2014/10/16	rogid:1YwlbUPPuijisz7AJM4Qkp7yJBI9606	rogid:8FsGgIJWzsgWymaBqL5+0eQ/7qM9606	intact-crc:61D76189237B4D6F|rigid:dg6XGuf/+ytnRdIehQbNxc0AFwk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P22681	uniprotkb:P46109	intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033	intact:EBI-910|uniprotkb:A8KA44|intact:EBI-3451075|uniprotkb:D3DX35|ensembl:ENSP00000346300|ensembl:ENSP00000396646	psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym)	psi-mi:crkl_human(display_long)|uniprotkb:CRKL(gene name)|psi-mi:CRKL(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hartman et al. (2006)	pubmed:16982329|mint:MINT-7033842|doi:10.1016/j.exphem.2006.05.019	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6981252|mint:MINT-7103666	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377|mint:MINT-7103670(identity)	refseq:NP_005198.1|dip:DIP-29165N|ensembl:ENSG00000099942(gene)|ensembl:ENST00000354336(transcript)|ensembl:ENST00000411769(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001568"(blood vessel development)|go:"GO:0001655"(urogenital system development)|go:"GO:0001764"(neuron migration)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007254"(JNK cascade)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007416"(synapse assembly)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0008584"(male gonad development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016358"(dendrite development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035690"|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060465"(pharynx development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903977"(positive regulation of glial cell migration)|go:"GO:1904393"(regulation of skeletal muscle acetylcholine-gated channel clustering)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46109|rcsb pdb:2BZX|rcsb pdb:2BZY|rcsb pdb:2DBK|rcsb pdb:2EO3|rcsb pdb:2LQN|rcsb pdb:2LQW|reactome:R-HSA-170968|reactome:R-HSA-186763|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-9027284|reactome:R-HSA-912631|mint:MINT-7103668(identity)	-	-	-	comment:homomint|comment:mint|figure legend:f3h|curation depth:mimix curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2009/05/25	2014/10/16	rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606	rogid:1YwlbUPPuijisz7AJM4Qkp7yJBI9606	intact-crc:FC9B87F1A6643AC8|rigid:AOezx21B1+3jk6uKIxuKTXGdmKM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P45983	uniprotkb:P46108	intact:EBI-286483|uniprotkb:Q15709|uniprotkb:Q15712|uniprotkb:Q15713|uniprotkb:B7ZLV4|uniprotkb:B5BTZ5|uniprotkb:Q308M2|uniprotkb:D3DX88|uniprotkb:D3DX92|ensembl:ENSP00000363304	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	psi-mi:mk08_human(display_long)|uniprotkb:MAPK8(gene name)|psi-mi:MAPK8(display_short)|uniprotkb:JNK1(gene name synonym)|uniprotkb:PRKM8(gene name synonym)|uniprotkb:Stress-activated protein kinase JNK1(gene name synonym)|uniprotkb:c-Jun N-terminal kinase 1(gene name synonym)|uniprotkb:JNK-46(gene name synonym)|uniprotkb:SAPK1(gene name synonym)|uniprotkb:Stress-activated protein kinase 1c(gene name synonym)|uniprotkb:SAPK1C(gene name synonym)	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hartman et al. (2006)	pubmed:16982329|mint:MINT-7033842|doi:10.1016/j.exphem.2006.05.019	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6981298|mint:MINT-7103547	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_620634.1|refseq:NP_620637.1|refseq:NP_001310231.1|refseq:NP_001310250.1|refseq:NP_001310251.1|refseq:NP_001310252.1|refseq:NP_001310253.1|refseq:NP_001310254.1|refseq:NP_001310255.1|refseq:NP_001310256.1|refseq:NP_001310257.1|refseq:NP_001310258.1|refseq:NP_001310259.1|refseq:NP_001310260.1|refseq:NP_001265476.1|refseq:NP_001265477.1|dip:DIP-249N|ensembl:ENSG00000107643(gene)|ensembl:ENST00000374189(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004705"(JUN kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007254"(JNK cascade)|go:"GO:0007258"(JUN phosphorylation)|go:"GO:0009411"(response to UV)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031343"(positive regulation of cell killing)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0048511"(rhythmic process)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090045"(positive regulation of deacetylase activity)|go:"GO:0090398"(cellular senescence)|go:"GO:0097441"(basal dendrite)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900740"(positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|go:"GO:1902595"(regulation of DNA replication origin binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008351(JNK MAP kinase)|interpro:IPR011009(Protein kinase-like)|mint:P45983|rcsb pdb:1UKH|rcsb pdb:1UKI|rcsb pdb:2G01|rcsb pdb:2GMX|rcsb pdb:2H96|rcsb pdb:2NO3|rcsb pdb:2XRW|rcsb pdb:2XS0|rcsb pdb:3ELJ|rcsb pdb:3O17|rcsb pdb:3O2M|rcsb pdb:3PZE|rcsb pdb:3V3V|rcsb pdb:3VUD|rcsb pdb:3VUG|rcsb pdb:3VUH|rcsb pdb:3VUI|rcsb pdb:3VUK|rcsb pdb:3VUL|rcsb pdb:3VUM|rcsb pdb:4AWI|rcsb pdb:4E73|rcsb pdb:4G1W|rcsb pdb:4HYS|rcsb pdb:4HYU|rcsb pdb:4IZY|rcsb pdb:4L7F|rcsb pdb:4QTD|rcsb pdb:4UX9|rcsb pdb:4YR8|rcsb pdb:5LW1|rcsb pdb:6F5E|rcsb pdb:6ZR5|reactome:R-HSA-111446|reactome:R-HSA-139910|reactome:R-HSA-193648|reactome:R-HSA-205043|reactome:R-HSA-2559580|reactome:R-HSA-2871796|reactome:R-HSA-376172|reactome:R-HSA-450321|reactome:R-HSA-450341|reactome:R-HSA-5693565|reactome:R-HSA-9007892|reactome:R-HSA-9673324|mint:MINT-7103550(identity)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|mint:MINT-7103549(identity)	-	-	-	comment:homomint|comment:domino|comment:mint|figure legend:f3i|curation depth:mimix curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/05/25	2014/10/16	rogid:8FsGgIJWzsgWymaBqL5+0eQ/7qM9606	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	intact-crc:661A013B5A98E876|rigid:nTI7sTiDyryKA3UtbpACq9hQkdo	false	-	binding-associated region:120-225(MINT-7103558)|glutathione s tranferase tag:?-?(MINT-7103555)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)