#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P18084	uniprotkb:P04004	intact:EBI-1223434|uniprotkb:B0LPF8|uniprotkb:B2RD70|ensembl:ENSP00000296181	intact:EBI-1036653|uniprotkb:P01141|uniprotkb:Q9BSH7|uniprotkb:B2R7G0|ensembl:ENSP00000226218	psi-mi:itb5_human(display_long)|uniprotkb:ITGB5(gene name)|psi-mi:ITGB5(display_short)	psi-mi:vtnc_human(display_long)|uniprotkb:VTN(gene name)|psi-mi:VTN(display_short)|uniprotkb:Serum-spreading factor(gene name synonym)|uniprotkb:V75(gene name synonym)|uniprotkb:S-protein(gene name synonym)	psi-mi:"MI:0892"(solid phase assay)	Smith et al. (1990)	pubmed:1694173|imex:IM-19205	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2436006|imex:IM-19205-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002204.2|ensembl:ENSG00000082781(gene)|ensembl:ENST00000296181(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034684"(integrin alphav-beta5 complex)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043235"(receptor complex)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090136"(epithelial cell-cell adhesion)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027067|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|interpro:IPR040622|mint:P18084|reactome:R-HSA-1236973|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-445355	refseq:NP_000629.3|ensembl:ENSG00000109072(gene)|ensembl:ENST00000226218(transcript)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008201"(heparin binding)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0061302"(smooth muscle cell-matrix adhesion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071062"(alphav-beta3 integrin-vitronectin complex)|go:"GO:0072562"(blood microparticle)|go:"GO:0090303"(positive regulation of wound healing)|interpro:IPR000585(Hemopexin)|interpro:IPR001212(Somatomedin B)|interpro:IPR018486|interpro:IPR018487|interpro:IPR020436|interpro:IPR036024|interpro:IPR036375|mint:P04004|rcsb pdb:1OC0|rcsb pdb:1S4G|rcsb pdb:1SSU|rcsb pdb:2JQ8|rcsb pdb:3BT1|rcsb pdb:3BT2|rcsb pdb:4K24|rcsb pdb:6O5E|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-977606|dip:DIP-36566N	-	-	-	figure legend:8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/09/16	2014/10/16	rogid:AKEnIHjRIjtfCHSUvpAkkWZFAu89606	rogid:07qxfQS6kbUZGwPyNj8/LTetT6I9606	intact-crc:B000E58243156054|rigid:R7TFTLoi1iQc0xe46SYXw6pGaew	false	-	biotin tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P18084	uniprotkb:P06756	intact:EBI-1223434|uniprotkb:B0LPF8|uniprotkb:B2RD70|ensembl:ENSP00000296181	intact:EBI-298282|ensembl:ENSP00000261023|uniprotkb:A0AV67|uniprotkb:Q53SK4|uniprotkb:Q59EB7|uniprotkb:Q6LD15|uniprotkb:D3DPG8|intact:EBI-10984285|uniprotkb:B0LPF4|uniprotkb:B7Z883|uniprotkb:E7EWZ6|uniprotkb:B7ZLX0	psi-mi:itb5_human(display_long)|uniprotkb:ITGB5(gene name)|psi-mi:ITGB5(display_short)	psi-mi:itav_human(display_long)|uniprotkb:ITGAV(gene name)|psi-mi:ITGAV(display_short)|uniprotkb:VNRA(gene name synonym)|uniprotkb:Vitronectin receptor subunit alpha(gene name synonym)|uniprotkb:MSK8(gene name synonym)|uniprotkb:Vitronectin receptor(gene name synonym)|uniprotkb:VTNR(gene name synonym)	psi-mi:"MI:0892"(solid phase assay)	Smith et al. (1990)	pubmed:1694173|imex:IM-19205	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2436006|imex:IM-19205-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002204.2|ensembl:ENSG00000082781(gene)|ensembl:ENST00000296181(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034684"(integrin alphav-beta5 complex)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043235"(receptor complex)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090136"(epithelial cell-cell adhesion)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027067|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|interpro:IPR040622|mint:P18084|reactome:R-HSA-1236973|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-445355	ensembl:ENSG00000138448(gene)|ensembl:ENST00000261023(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001846"(opsonin binding)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008305"(integrin complex)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0009986"(cell surface)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:1990430"(extracellular matrix protein binding)|go:"GO:2000536"(negative regulation of entry of bacterium into host cell)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|mint:P06756|rcsb pdb:1JV2|rcsb pdb:1L5G|rcsb pdb:1M1X|rcsb pdb:1U8C|rcsb pdb:3IJE|rcsb pdb:4G1E|rcsb pdb:4G1M|rcsb pdb:4MMX|rcsb pdb:4MMY|rcsb pdb:4MMZ|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|rcsb pdb:4O02|rcsb pdb:4UM8|reactome:R-HSA-210990|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-4420097|reactome:R-HSA-445144|reactome:R-HSA-6798695|rcsb pdb:5FFG|rcsb pdb:5FFO|rcsb pdb:5NEM|rcsb pdb:5NER|rcsb pdb:5NET|rcsb pdb:5NEU|rcsb pdb:6AVQ|rcsb pdb:6AVR|rcsb pdb:6AVU|rcsb pdb:6DJP|rcsb pdb:6MK0|rcsb pdb:6MSL|rcsb pdb:6MSU|rcsb pdb:6NAJ|rcsb pdb:6OM1|rcsb pdb:6OM2|rcsb pdb:6UJA|rcsb pdb:6UJB|rcsb pdb:4UM9|rcsb pdb:6UJC|reactome:R-HSA-1236973|reactome:R-HSA-1566948|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034683"(integrin alphav-beta3 complex)|go:"GO:0034684"(integrin alphav-beta5 complex)|go:"GO:0034685"(integrin alphav-beta6 complex)|go:"GO:0034686"(integrin alphav-beta8 complex)|go:"GO:0035579"(specific granule membrane)|go:"GO:0035866"(alphav-beta3 integrin-PKCalpha complex)|go:"GO:0035867"(alphav-beta3 integrin-IGF-1-IGF1R complex)|go:"GO:0035868"(alphav-beta3 integrin-HMGB1 complex)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0038027"(apolipoprotein A-I-mediated signaling pathway)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050748"(negative regulation of lipoprotein metabolic process)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071604"(transforming growth factor beta production)|go:"GO:0085017"(entry into host cell by a symbiont-containing vacuole)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1901388"(regulation of transforming growth factor beta activation)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|refseq:NP_001138472.1|refseq:NP_002201.1|refseq:NP_001138471.1|dip:DIP-31785N	-	-	-	figure legend:8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/09/16	2014/10/16	rogid:AKEnIHjRIjtfCHSUvpAkkWZFAu89606	rogid:3XbANVuHd/2LJX6zckEV6xx09mY9606	intact-crc:B000E58243156054|rigid:R7TFTLoi1iQc0xe46SYXw6pGaew	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06756	uniprotkb:P04004	intact:EBI-298282|ensembl:ENSP00000261023|uniprotkb:A0AV67|uniprotkb:Q53SK4|uniprotkb:Q59EB7|uniprotkb:Q6LD15|uniprotkb:D3DPG8|intact:EBI-10984285|uniprotkb:B0LPF4|uniprotkb:B7Z883|uniprotkb:E7EWZ6|uniprotkb:B7ZLX0	intact:EBI-1036653|uniprotkb:P01141|uniprotkb:Q9BSH7|uniprotkb:B2R7G0|ensembl:ENSP00000226218	psi-mi:itav_human(display_long)|uniprotkb:ITGAV(gene name)|psi-mi:ITGAV(display_short)|uniprotkb:VNRA(gene name synonym)|uniprotkb:Vitronectin receptor subunit alpha(gene name synonym)|uniprotkb:MSK8(gene name synonym)|uniprotkb:Vitronectin receptor(gene name synonym)|uniprotkb:VTNR(gene name synonym)	psi-mi:vtnc_human(display_long)|uniprotkb:VTN(gene name)|psi-mi:VTN(display_short)|uniprotkb:Serum-spreading factor(gene name synonym)|uniprotkb:V75(gene name synonym)|uniprotkb:S-protein(gene name synonym)	psi-mi:"MI:0892"(solid phase assay)	Smith et al. (1990)	pubmed:1694173|imex:IM-19205	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2436340|imex:IM-19205-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000138448(gene)|ensembl:ENST00000261023(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001846"(opsonin binding)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008305"(integrin complex)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0009986"(cell surface)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:1990430"(extracellular matrix protein binding)|go:"GO:2000536"(negative regulation of entry of bacterium into host cell)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|mint:P06756|rcsb pdb:1JV2|rcsb pdb:1L5G|rcsb pdb:1M1X|rcsb pdb:1U8C|rcsb pdb:3IJE|rcsb pdb:4G1E|rcsb pdb:4G1M|rcsb pdb:4MMX|rcsb pdb:4MMY|rcsb pdb:4MMZ|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|rcsb pdb:4O02|rcsb pdb:4UM8|reactome:R-HSA-210990|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-4420097|reactome:R-HSA-445144|reactome:R-HSA-6798695|rcsb pdb:5FFG|rcsb pdb:5FFO|rcsb pdb:5NEM|rcsb pdb:5NER|rcsb pdb:5NET|rcsb pdb:5NEU|rcsb pdb:6AVQ|rcsb pdb:6AVR|rcsb pdb:6AVU|rcsb pdb:6DJP|rcsb pdb:6MK0|rcsb pdb:6MSL|rcsb pdb:6MSU|rcsb pdb:6NAJ|rcsb pdb:6OM1|rcsb pdb:6OM2|rcsb pdb:6UJA|rcsb pdb:6UJB|rcsb pdb:4UM9|rcsb pdb:6UJC|reactome:R-HSA-1236973|reactome:R-HSA-1566948|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034683"(integrin alphav-beta3 complex)|go:"GO:0034684"(integrin alphav-beta5 complex)|go:"GO:0034685"(integrin alphav-beta6 complex)|go:"GO:0034686"(integrin alphav-beta8 complex)|go:"GO:0035579"(specific granule membrane)|go:"GO:0035866"(alphav-beta3 integrin-PKCalpha complex)|go:"GO:0035867"(alphav-beta3 integrin-IGF-1-IGF1R complex)|go:"GO:0035868"(alphav-beta3 integrin-HMGB1 complex)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0038027"(apolipoprotein A-I-mediated signaling pathway)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050748"(negative regulation of lipoprotein metabolic process)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071604"(transforming growth factor beta production)|go:"GO:0085017"(entry into host cell by a symbiont-containing vacuole)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1901388"(regulation of transforming growth factor beta activation)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|refseq:NP_001138472.1|refseq:NP_002201.1|refseq:NP_001138471.1|dip:DIP-31785N	refseq:NP_000629.3|ensembl:ENSG00000109072(gene)|ensembl:ENST00000226218(transcript)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008201"(heparin binding)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0061302"(smooth muscle cell-matrix adhesion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071062"(alphav-beta3 integrin-vitronectin complex)|go:"GO:0072562"(blood microparticle)|go:"GO:0090303"(positive regulation of wound healing)|interpro:IPR000585(Hemopexin)|interpro:IPR001212(Somatomedin B)|interpro:IPR018486|interpro:IPR018487|interpro:IPR020436|interpro:IPR036024|interpro:IPR036375|mint:P04004|rcsb pdb:1OC0|rcsb pdb:1S4G|rcsb pdb:1SSU|rcsb pdb:2JQ8|rcsb pdb:3BT1|rcsb pdb:3BT2|rcsb pdb:4K24|rcsb pdb:6O5E|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-977606|dip:DIP-36566N	-	-	-	figure legend:8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/09/16	2014/10/16	rogid:3XbANVuHd/2LJX6zckEV6xx09mY9606	rogid:07qxfQS6kbUZGwPyNj8/LTetT6I9606	intact-crc:157A1BE904FABF97|rigid:sLecGGXPCg3Hd26k70ucld9GDDk	false	-	biotin tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06756	uniprotkb:P05106	intact:EBI-298282|ensembl:ENSP00000261023|uniprotkb:A0AV67|uniprotkb:Q53SK4|uniprotkb:Q59EB7|uniprotkb:Q6LD15|uniprotkb:D3DPG8|intact:EBI-10984285|uniprotkb:B0LPF4|uniprotkb:B7Z883|uniprotkb:E7EWZ6|uniprotkb:B7ZLX0	intact:EBI-702847|uniprotkb:A0PJW2|uniprotkb:O15495|uniprotkb:Q12806|uniprotkb:Q13413|uniprotkb:Q14648|uniprotkb:Q16499|uniprotkb:D3DXJ8|ensembl:ENSP00000452786	psi-mi:itav_human(display_long)|uniprotkb:ITGAV(gene name)|psi-mi:ITGAV(display_short)|uniprotkb:VNRA(gene name synonym)|uniprotkb:Vitronectin receptor subunit alpha(gene name synonym)|uniprotkb:MSK8(gene name synonym)|uniprotkb:Vitronectin receptor(gene name synonym)|uniprotkb:VTNR(gene name synonym)	psi-mi:itb3_human(display_long)|uniprotkb:Platelet membrane glycoprotein IIIa(gene name synonym)|uniprotkb:ITGB3(gene name)|psi-mi:ITGB3(display_short)|uniprotkb:GP3A(gene name synonym)	psi-mi:"MI:0892"(solid phase assay)	Smith et al. (1990)	pubmed:1694173|imex:IM-19205	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2436340|imex:IM-19205-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000138448(gene)|ensembl:ENST00000261023(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001846"(opsonin binding)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008305"(integrin complex)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0009986"(cell surface)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:1990430"(extracellular matrix protein binding)|go:"GO:2000536"(negative regulation of entry of bacterium into host cell)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|mint:P06756|rcsb pdb:1JV2|rcsb pdb:1L5G|rcsb pdb:1M1X|rcsb pdb:1U8C|rcsb pdb:3IJE|rcsb pdb:4G1E|rcsb pdb:4G1M|rcsb pdb:4MMX|rcsb pdb:4MMY|rcsb pdb:4MMZ|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|rcsb pdb:4O02|rcsb pdb:4UM8|reactome:R-HSA-210990|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-4420097|reactome:R-HSA-445144|reactome:R-HSA-6798695|rcsb pdb:5FFG|rcsb pdb:5FFO|rcsb pdb:5NEM|rcsb pdb:5NER|rcsb pdb:5NET|rcsb pdb:5NEU|rcsb pdb:6AVQ|rcsb pdb:6AVR|rcsb pdb:6AVU|rcsb pdb:6DJP|rcsb pdb:6MK0|rcsb pdb:6MSL|rcsb pdb:6MSU|rcsb pdb:6NAJ|rcsb pdb:6OM1|rcsb pdb:6OM2|rcsb pdb:6UJA|rcsb pdb:6UJB|rcsb pdb:4UM9|rcsb pdb:6UJC|reactome:R-HSA-1236973|reactome:R-HSA-1566948|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034683"(integrin alphav-beta3 complex)|go:"GO:0034684"(integrin alphav-beta5 complex)|go:"GO:0034685"(integrin alphav-beta6 complex)|go:"GO:0034686"(integrin alphav-beta8 complex)|go:"GO:0035579"(specific granule membrane)|go:"GO:0035866"(alphav-beta3 integrin-PKCalpha complex)|go:"GO:0035867"(alphav-beta3 integrin-IGF-1-IGF1R complex)|go:"GO:0035868"(alphav-beta3 integrin-HMGB1 complex)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0038027"(apolipoprotein A-I-mediated signaling pathway)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050748"(negative regulation of lipoprotein metabolic process)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071604"(transforming growth factor beta production)|go:"GO:0085017"(entry into host cell by a symbiont-containing vacuole)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1901388"(regulation of transforming growth factor beta activation)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|refseq:NP_001138472.1|refseq:NP_002201.1|refseq:NP_001138471.1|dip:DIP-31785N	refseq:NP_000203.2|dip:DIP-304N|ensembl:ENSG00000259207(gene)|ensembl:ENST00000559488(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007596"(blood coagulation)|go:"GO:0008305"(integrin complex)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0014909"(smooth muscle cell migration)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016477"(cell migration)|go:"GO:0019899"(enzyme binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034683"(integrin alphav-beta3 complex)|go:"GO:0035295"(tube development)|go:"GO:0035866"(alphav-beta3 integrin-PKCalpha complex)|go:"GO:0035867"(alphav-beta3 integrin-IGF-1-IGF1R complex)|go:"GO:0035868"(alphav-beta3 integrin-HMGB1 complex)|go:"GO:0038027"(apolipoprotein A-I-mediated signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050748"(negative regulation of lipoprotein metabolic process)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051611"(regulation of serotonin uptake)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071062"(alphav-beta3 integrin-vitronectin complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027068|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|interpro:IPR040622|mint:P05106|rcsb pdb:1JV2|rcsb pdb:1KUP|rcsb pdb:1KUZ|rcsb pdb:1L5G|rcsb pdb:1M1X|rcsb pdb:1M8O|rcsb pdb:1MIZ|rcsb pdb:1MK7|rcsb pdb:1MK9|rcsb pdb:1RN0|rcsb pdb:1S4X|rcsb pdb:1TYE|rcsb pdb:1U8C|rcsb pdb:2INI|rcsb pdb:2K9J|rcsb pdb:2KNC|rcsb pdb:2KV9|rcsb pdb:2L1C|rcsb pdb:2L91|rcsb pdb:2LJD|rcsb pdb:2LJE|rcsb pdb:2LJF|rcsb pdb:2MTP|rcsb pdb:2N9Y|rcsb pdb:2Q6W|rcsb pdb:2RMZ|rcsb pdb:2RN0|rcsb pdb:2VC2|rcsb pdb:2VDK|rcsb pdb:2VDL|rcsb pdb:2VDM|rcsb pdb:2VDN|rcsb pdb:2VDO|rcsb pdb:2VDP|rcsb pdb:2VDQ|rcsb pdb:2VDR|rcsb pdb:3FCS|rcsb pdb:3FCU|rcsb pdb:3IJE|rcsb pdb:3NID|rcsb pdb:3NIF|rcsb pdb:3NIG|rcsb pdb:3T3M|rcsb pdb:3T3P|rcsb pdb:3ZDX|rcsb pdb:3ZDY|rcsb pdb:3ZDZ|rcsb pdb:3ZE0|rcsb pdb:3ZE1|rcsb pdb:3ZE2|rcsb pdb:4CAK|rcsb pdb:4G1E|rcsb pdb:4G1M|rcsb pdb:4MMX|rcsb pdb:4MMY|rcsb pdb:4MMZ|rcsb pdb:4O02|rcsb pdb:4Z7N|rcsb pdb:4Z7O|rcsb pdb:4Z7Q|rcsb pdb:5HDB|rcsb pdb:6AVQ|rcsb pdb:6AVR|rcsb pdb:6AVU|rcsb pdb:6BXB|rcsb pdb:6BXF|rcsb pdb:6BXJ|rcsb pdb:6CKB|rcsb pdb:6MK0|rcsb pdb:6MSL|rcsb pdb:6MSU|rcsb pdb:6NAJ|rcsb pdb:6V4P|reactome:R-HSA-114608|reactome:R-HSA-1566948|reactome:R-HSA-210990|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-445144|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223	-	-	-	figure legend:8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/09/16	2014/10/16	rogid:3XbANVuHd/2LJX6zckEV6xx09mY9606	rogid:EnuaoGdEG3SOqzwmTfH1OwqKuzs9606	intact-crc:157A1BE904FABF97|rigid:sLecGGXPCg3Hd26k70ucld9GDDk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P05106	uniprotkb:P06756	intact:EBI-702847|uniprotkb:A0PJW2|uniprotkb:O15495|uniprotkb:Q12806|uniprotkb:Q13413|uniprotkb:Q14648|uniprotkb:Q16499|uniprotkb:D3DXJ8|ensembl:ENSP00000452786	intact:EBI-298282|ensembl:ENSP00000261023|uniprotkb:A0AV67|uniprotkb:Q53SK4|uniprotkb:Q59EB7|uniprotkb:Q6LD15|uniprotkb:D3DPG8|intact:EBI-10984285|uniprotkb:B0LPF4|uniprotkb:B7Z883|uniprotkb:E7EWZ6|uniprotkb:B7ZLX0	psi-mi:itb3_human(display_long)|uniprotkb:Platelet membrane glycoprotein IIIa(gene name synonym)|uniprotkb:ITGB3(gene name)|psi-mi:ITGB3(display_short)|uniprotkb:GP3A(gene name synonym)	psi-mi:itav_human(display_long)|uniprotkb:ITGAV(gene name)|psi-mi:ITGAV(display_short)|uniprotkb:VNRA(gene name synonym)|uniprotkb:Vitronectin receptor subunit alpha(gene name synonym)|uniprotkb:MSK8(gene name synonym)|uniprotkb:Vitronectin receptor(gene name synonym)|uniprotkb:VTNR(gene name synonym)	psi-mi:"MI:0892"(solid phase assay)	Smith et al. (1990)	pubmed:1694173|imex:IM-19205	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2436350|imex:IM-19205-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000203.2|dip:DIP-304N|ensembl:ENSG00000259207(gene)|ensembl:ENST00000559488(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007596"(blood coagulation)|go:"GO:0008305"(integrin complex)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0014909"(smooth muscle cell migration)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016477"(cell migration)|go:"GO:0019899"(enzyme binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034683"(integrin alphav-beta3 complex)|go:"GO:0035295"(tube development)|go:"GO:0035866"(alphav-beta3 integrin-PKCalpha complex)|go:"GO:0035867"(alphav-beta3 integrin-IGF-1-IGF1R complex)|go:"GO:0035868"(alphav-beta3 integrin-HMGB1 complex)|go:"GO:0038027"(apolipoprotein A-I-mediated signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050748"(negative regulation of lipoprotein metabolic process)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051611"(regulation of serotonin uptake)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071062"(alphav-beta3 integrin-vitronectin complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027068|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|interpro:IPR040622|mint:P05106|rcsb pdb:1JV2|rcsb pdb:1KUP|rcsb pdb:1KUZ|rcsb pdb:1L5G|rcsb pdb:1M1X|rcsb pdb:1M8O|rcsb pdb:1MIZ|rcsb pdb:1MK7|rcsb pdb:1MK9|rcsb pdb:1RN0|rcsb pdb:1S4X|rcsb pdb:1TYE|rcsb pdb:1U8C|rcsb pdb:2INI|rcsb pdb:2K9J|rcsb pdb:2KNC|rcsb pdb:2KV9|rcsb pdb:2L1C|rcsb pdb:2L91|rcsb pdb:2LJD|rcsb pdb:2LJE|rcsb pdb:2LJF|rcsb pdb:2MTP|rcsb pdb:2N9Y|rcsb pdb:2Q6W|rcsb pdb:2RMZ|rcsb pdb:2RN0|rcsb pdb:2VC2|rcsb pdb:2VDK|rcsb pdb:2VDL|rcsb pdb:2VDM|rcsb pdb:2VDN|rcsb pdb:2VDO|rcsb pdb:2VDP|rcsb pdb:2VDQ|rcsb pdb:2VDR|rcsb pdb:3FCS|rcsb pdb:3FCU|rcsb pdb:3IJE|rcsb pdb:3NID|rcsb pdb:3NIF|rcsb pdb:3NIG|rcsb pdb:3T3M|rcsb pdb:3T3P|rcsb pdb:3ZDX|rcsb pdb:3ZDY|rcsb pdb:3ZDZ|rcsb pdb:3ZE0|rcsb pdb:3ZE1|rcsb pdb:3ZE2|rcsb pdb:4CAK|rcsb pdb:4G1E|rcsb pdb:4G1M|rcsb pdb:4MMX|rcsb pdb:4MMY|rcsb pdb:4MMZ|rcsb pdb:4O02|rcsb pdb:4Z7N|rcsb pdb:4Z7O|rcsb pdb:4Z7Q|rcsb pdb:5HDB|rcsb pdb:6AVQ|rcsb pdb:6AVR|rcsb pdb:6AVU|rcsb pdb:6BXB|rcsb pdb:6BXF|rcsb pdb:6BXJ|rcsb pdb:6CKB|rcsb pdb:6MK0|rcsb pdb:6MSL|rcsb pdb:6MSU|rcsb pdb:6NAJ|rcsb pdb:6V4P|reactome:R-HSA-114608|reactome:R-HSA-1566948|reactome:R-HSA-210990|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-445144|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223	ensembl:ENSG00000138448(gene)|ensembl:ENST00000261023(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001846"(opsonin binding)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008305"(integrin complex)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0009986"(cell surface)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:1990430"(extracellular matrix protein binding)|go:"GO:2000536"(negative regulation of entry of bacterium into host cell)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|mint:P06756|rcsb pdb:1JV2|rcsb pdb:1L5G|rcsb pdb:1M1X|rcsb pdb:1U8C|rcsb pdb:3IJE|rcsb pdb:4G1E|rcsb pdb:4G1M|rcsb pdb:4MMX|rcsb pdb:4MMY|rcsb pdb:4MMZ|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|rcsb pdb:4O02|rcsb pdb:4UM8|reactome:R-HSA-210990|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-4420097|reactome:R-HSA-445144|reactome:R-HSA-6798695|rcsb pdb:5FFG|rcsb pdb:5FFO|rcsb pdb:5NEM|rcsb pdb:5NER|rcsb pdb:5NET|rcsb pdb:5NEU|rcsb pdb:6AVQ|rcsb pdb:6AVR|rcsb pdb:6AVU|rcsb pdb:6DJP|rcsb pdb:6MK0|rcsb pdb:6MSL|rcsb pdb:6MSU|rcsb pdb:6NAJ|rcsb pdb:6OM1|rcsb pdb:6OM2|rcsb pdb:6UJA|rcsb pdb:6UJB|rcsb pdb:4UM9|rcsb pdb:6UJC|reactome:R-HSA-1236973|reactome:R-HSA-1566948|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034683"(integrin alphav-beta3 complex)|go:"GO:0034684"(integrin alphav-beta5 complex)|go:"GO:0034685"(integrin alphav-beta6 complex)|go:"GO:0034686"(integrin alphav-beta8 complex)|go:"GO:0035579"(specific granule membrane)|go:"GO:0035866"(alphav-beta3 integrin-PKCalpha complex)|go:"GO:0035867"(alphav-beta3 integrin-IGF-1-IGF1R complex)|go:"GO:0035868"(alphav-beta3 integrin-HMGB1 complex)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0038027"(apolipoprotein A-I-mediated signaling pathway)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050748"(negative regulation of lipoprotein metabolic process)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071604"(transforming growth factor beta production)|go:"GO:0085017"(entry into host cell by a symbiont-containing vacuole)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1901388"(regulation of transforming growth factor beta activation)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|refseq:NP_001138472.1|refseq:NP_002201.1|refseq:NP_001138471.1|dip:DIP-31785N	-	-	-	figure legend:8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/09/16	2019/10/18	rogid:EnuaoGdEG3SOqzwmTfH1OwqKuzs9606	rogid:3XbANVuHd/2LJX6zckEV6xx09mY9606	intact-crc:32B7831133CB8144|rigid:muFzQWdtegEzDBweICcdwPSPbiI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P05106	uniprotkb:P02751	intact:EBI-702847|uniprotkb:A0PJW2|uniprotkb:O15495|uniprotkb:Q12806|uniprotkb:Q13413|uniprotkb:Q14648|uniprotkb:Q16499|uniprotkb:D3DXJ8|ensembl:ENSP00000452786	intact:EBI-1220319|uniprotkb:Q7Z391|uniprotkb:O95609|uniprotkb:O95610|uniprotkb:Q14312|uniprotkb:Q14325|uniprotkb:Q14326|uniprotkb:Q17RV7|uniprotkb:Q585T2|uniprotkb:Q59EH1|uniprotkb:Q60FE4|uniprotkb:Q68DP8|uniprotkb:Q68DP9|uniprotkb:Q68DT4|uniprotkb:Q6LDP6|uniprotkb:Q6MZU5|uniprotkb:Q6N025|uniprotkb:Q6N0A6|uniprotkb:Q86T27|uniprotkb:Q8IVI8|uniprotkb:Q96KP7|uniprotkb:Q96KP8|uniprotkb:Q96KP9|uniprotkb:Q9H1B8|uniprotkb:Q9HAP3|uniprotkb:Q9UMK2|uniprotkb:Q6MZS0|uniprotkb:B7ZLF0|uniprotkb:E9PE77|uniprotkb:E9PG29|uniprotkb:Q564H7|uniprotkb:Q53S27|ensembl:ENSP00000346839	psi-mi:itb3_human(display_long)|uniprotkb:Platelet membrane glycoprotein IIIa(gene name synonym)|uniprotkb:ITGB3(gene name)|psi-mi:ITGB3(display_short)|uniprotkb:GP3A(gene name synonym)	psi-mi:finc_human(display_long)|uniprotkb:FN1(gene name)|psi-mi:FN1(display_short)|uniprotkb:FN(gene name synonym)|uniprotkb:Cold-insoluble globulin(gene name synonym)	psi-mi:"MI:0892"(solid phase assay)	Smith et al. (1990)	pubmed:1694173|imex:IM-19205	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2436350|imex:IM-19205-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000203.2|dip:DIP-304N|ensembl:ENSG00000259207(gene)|ensembl:ENST00000559488(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007596"(blood coagulation)|go:"GO:0008305"(integrin complex)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0014909"(smooth muscle cell migration)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016477"(cell migration)|go:"GO:0019899"(enzyme binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034683"(integrin alphav-beta3 complex)|go:"GO:0035295"(tube development)|go:"GO:0035866"(alphav-beta3 integrin-PKCalpha complex)|go:"GO:0035867"(alphav-beta3 integrin-IGF-1-IGF1R complex)|go:"GO:0035868"(alphav-beta3 integrin-HMGB1 complex)|go:"GO:0038027"(apolipoprotein A-I-mediated signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050748"(negative regulation of lipoprotein metabolic process)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051611"(regulation of serotonin uptake)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071062"(alphav-beta3 integrin-vitronectin complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027068|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|interpro:IPR040622|mint:P05106|rcsb pdb:1JV2|rcsb pdb:1KUP|rcsb pdb:1KUZ|rcsb pdb:1L5G|rcsb pdb:1M1X|rcsb pdb:1M8O|rcsb pdb:1MIZ|rcsb pdb:1MK7|rcsb pdb:1MK9|rcsb pdb:1RN0|rcsb pdb:1S4X|rcsb pdb:1TYE|rcsb pdb:1U8C|rcsb pdb:2INI|rcsb pdb:2K9J|rcsb pdb:2KNC|rcsb pdb:2KV9|rcsb pdb:2L1C|rcsb pdb:2L91|rcsb pdb:2LJD|rcsb pdb:2LJE|rcsb pdb:2LJF|rcsb pdb:2MTP|rcsb pdb:2N9Y|rcsb pdb:2Q6W|rcsb pdb:2RMZ|rcsb pdb:2RN0|rcsb pdb:2VC2|rcsb pdb:2VDK|rcsb pdb:2VDL|rcsb pdb:2VDM|rcsb pdb:2VDN|rcsb pdb:2VDO|rcsb pdb:2VDP|rcsb pdb:2VDQ|rcsb pdb:2VDR|rcsb pdb:3FCS|rcsb pdb:3FCU|rcsb pdb:3IJE|rcsb pdb:3NID|rcsb pdb:3NIF|rcsb pdb:3NIG|rcsb pdb:3T3M|rcsb pdb:3T3P|rcsb pdb:3ZDX|rcsb pdb:3ZDY|rcsb pdb:3ZDZ|rcsb pdb:3ZE0|rcsb pdb:3ZE1|rcsb pdb:3ZE2|rcsb pdb:4CAK|rcsb pdb:4G1E|rcsb pdb:4G1M|rcsb pdb:4MMX|rcsb pdb:4MMY|rcsb pdb:4MMZ|rcsb pdb:4O02|rcsb pdb:4Z7N|rcsb pdb:4Z7O|rcsb pdb:4Z7Q|rcsb pdb:5HDB|rcsb pdb:6AVQ|rcsb pdb:6AVR|rcsb pdb:6AVU|rcsb pdb:6BXB|rcsb pdb:6BXF|rcsb pdb:6BXJ|rcsb pdb:6CKB|rcsb pdb:6MK0|rcsb pdb:6MSL|rcsb pdb:6MSU|rcsb pdb:6NAJ|rcsb pdb:6V4P|reactome:R-HSA-114608|reactome:R-HSA-1566948|reactome:R-HSA-210990|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-445144|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223	refseq:NP_002017.1|refseq:NP_473375.2|refseq:NP_997639.1|refseq:NP_997641.1|refseq:NP_997643.1|refseq:NP_997647.1|refseq:NP_001293058.1|refseq:NP_001293059.1|refseq:NP_001293060.1|refseq:NP_001293061.1|refseq:XP_005246463.1|dip:DIP-29547N|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009611"(response to wounding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0019899"(enzyme binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0033622"(integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0051087"(chaperone binding)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|ensembl:ENSG00000115414(gene)|ensembl:ENST00000354785(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006953"(acute-phase response)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0072562"(blood microparticle)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|interpro:IPR000083(Fibronectin, type I)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036116|interpro:IPR036943|mint:P02751|rcsb pdb:1E88|rcsb pdb:1E8B|rcsb pdb:1FBR|rcsb pdb:1FNA|rcsb pdb:1FNF|rcsb pdb:1FNH|rcsb pdb:1J8K|rcsb pdb:1O9A|rcsb pdb:1OWW|rcsb pdb:1Q38|rcsb pdb:1QGB|rcsb pdb:1QO6|rcsb pdb:1TTF|rcsb pdb:1TTG|rcsb pdb:2CG6|rcsb pdb:2CG7|rcsb pdb:2CK2|rcsb pdb:2CKU|rcsb pdb:2EC3|rcsb pdb:2FN2|rcsb pdb:2FNB|rcsb pdb:2GEE|rcsb pdb:2H41|rcsb pdb:2H45|rcsb pdb:2HA1|rcsb pdb:2MNU|rcsb pdb:2N1K|rcsb pdb:2OCF|rcsb pdb:2RKY|rcsb pdb:2RKZ|rcsb pdb:2RL0|rcsb pdb:3CAL|rcsb pdb:3EJH|rcsb pdb:3GXE|rcsb pdb:3M7P|rcsb pdb:3MQL|rcsb pdb:3R8Q|rcsb pdb:3T1W|rcsb pdb:3ZRZ|rcsb pdb:4GH7|rcsb pdb:4JE4|rcsb pdb:4JEG|rcsb pdb:4LXO|rcsb pdb:4MMX|rcsb pdb:4MMY|rcsb pdb:4MMZ|rcsb pdb:4PZ5|rcsb pdb:5DC0|rcsb pdb:5DC4|rcsb pdb:5DC9|rcsb pdb:5DFT|rcsb pdb:5J6Z|rcsb pdb:5J7C|rcsb pdb:5M0A|rcsb pdb:5N47|rcsb pdb:5N48|rcsb pdb:6HNF|rcsb pdb:6MFA|rcsb pdb:6MSV|rcsb pdb:6NAJ|rcsb pdb:6XAX|rcsb pdb:6XAY|rcsb pdb:7NWL|reactome:R-HSA-114608|reactome:R-HSA-1474228|reactome:R-HSA-1474244|reactome:R-HSA-1566977|reactome:R-HSA-202733|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-3000171|reactome:R-HSA-3000178|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-381426|reactome:R-HSA-5674135|reactome:R-HSA-6785807|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8874081|reactome:R-HSA-8957275|reactome:R-HSA-9649948|reactome:R-HSA-9656223	-	-	-	figure legend:8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/09/16	2019/10/18	rogid:EnuaoGdEG3SOqzwmTfH1OwqKuzs9606	rogid:4arZu49X8b+dthqaX4DIh59V8h09606	intact-crc:32B7831133CB8144|rigid:muFzQWdtegEzDBweICcdwPSPbiI	false	-	biotin tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06756	uniprotkb:P05106	intact:EBI-298282|ensembl:ENSP00000261023|uniprotkb:A0AV67|uniprotkb:Q53SK4|uniprotkb:Q59EB7|uniprotkb:Q6LD15|uniprotkb:D3DPG8|intact:EBI-10984285|uniprotkb:B0LPF4|uniprotkb:B7Z883|uniprotkb:E7EWZ6|uniprotkb:B7ZLX0	intact:EBI-702847|uniprotkb:A0PJW2|uniprotkb:O15495|uniprotkb:Q12806|uniprotkb:Q13413|uniprotkb:Q14648|uniprotkb:Q16499|uniprotkb:D3DXJ8|ensembl:ENSP00000452786	psi-mi:itav_human(display_long)|uniprotkb:ITGAV(gene name)|psi-mi:ITGAV(display_short)|uniprotkb:VNRA(gene name synonym)|uniprotkb:Vitronectin receptor subunit alpha(gene name synonym)|uniprotkb:MSK8(gene name synonym)|uniprotkb:Vitronectin receptor(gene name synonym)|uniprotkb:VTNR(gene name synonym)	psi-mi:itb3_human(display_long)|uniprotkb:Platelet membrane glycoprotein IIIa(gene name synonym)|uniprotkb:ITGB3(gene name)|psi-mi:ITGB3(display_short)|uniprotkb:GP3A(gene name synonym)	psi-mi:"MI:0892"(solid phase assay)	Smith et al. (1990)	pubmed:1694173|imex:IM-19205	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2436358|imex:IM-19205-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000138448(gene)|ensembl:ENST00000261023(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001846"(opsonin binding)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008305"(integrin complex)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0009986"(cell surface)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:1990430"(extracellular matrix protein binding)|go:"GO:2000536"(negative regulation of entry of bacterium into host cell)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|mint:P06756|rcsb pdb:1JV2|rcsb pdb:1L5G|rcsb pdb:1M1X|rcsb pdb:1U8C|rcsb pdb:3IJE|rcsb pdb:4G1E|rcsb pdb:4G1M|rcsb pdb:4MMX|rcsb pdb:4MMY|rcsb pdb:4MMZ|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|rcsb pdb:4O02|rcsb pdb:4UM8|reactome:R-HSA-210990|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-4420097|reactome:R-HSA-445144|reactome:R-HSA-6798695|rcsb pdb:5FFG|rcsb pdb:5FFO|rcsb pdb:5NEM|rcsb pdb:5NER|rcsb pdb:5NET|rcsb pdb:5NEU|rcsb pdb:6AVQ|rcsb pdb:6AVR|rcsb pdb:6AVU|rcsb pdb:6DJP|rcsb pdb:6MK0|rcsb pdb:6MSL|rcsb pdb:6MSU|rcsb pdb:6NAJ|rcsb pdb:6OM1|rcsb pdb:6OM2|rcsb pdb:6UJA|rcsb pdb:6UJB|rcsb pdb:4UM9|rcsb pdb:6UJC|reactome:R-HSA-1236973|reactome:R-HSA-1566948|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034683"(integrin alphav-beta3 complex)|go:"GO:0034684"(integrin alphav-beta5 complex)|go:"GO:0034685"(integrin alphav-beta6 complex)|go:"GO:0034686"(integrin alphav-beta8 complex)|go:"GO:0035579"(specific granule membrane)|go:"GO:0035866"(alphav-beta3 integrin-PKCalpha complex)|go:"GO:0035867"(alphav-beta3 integrin-IGF-1-IGF1R complex)|go:"GO:0035868"(alphav-beta3 integrin-HMGB1 complex)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0038027"(apolipoprotein A-I-mediated signaling pathway)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050748"(negative regulation of lipoprotein metabolic process)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071604"(transforming growth factor beta production)|go:"GO:0085017"(entry into host cell by a symbiont-containing vacuole)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1901388"(regulation of transforming growth factor beta activation)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|refseq:NP_001138472.1|refseq:NP_002201.1|refseq:NP_001138471.1|dip:DIP-31785N	refseq:NP_000203.2|dip:DIP-304N|ensembl:ENSG00000259207(gene)|ensembl:ENST00000559488(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007596"(blood coagulation)|go:"GO:0008305"(integrin complex)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0014909"(smooth muscle cell migration)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016477"(cell migration)|go:"GO:0019899"(enzyme binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034683"(integrin alphav-beta3 complex)|go:"GO:0035295"(tube development)|go:"GO:0035866"(alphav-beta3 integrin-PKCalpha complex)|go:"GO:0035867"(alphav-beta3 integrin-IGF-1-IGF1R complex)|go:"GO:0035868"(alphav-beta3 integrin-HMGB1 complex)|go:"GO:0038027"(apolipoprotein A-I-mediated signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050748"(negative regulation of lipoprotein metabolic process)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051611"(regulation of serotonin uptake)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071062"(alphav-beta3 integrin-vitronectin complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027068|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|interpro:IPR040622|mint:P05106|rcsb pdb:1JV2|rcsb pdb:1KUP|rcsb pdb:1KUZ|rcsb pdb:1L5G|rcsb pdb:1M1X|rcsb pdb:1M8O|rcsb pdb:1MIZ|rcsb pdb:1MK7|rcsb pdb:1MK9|rcsb pdb:1RN0|rcsb pdb:1S4X|rcsb pdb:1TYE|rcsb pdb:1U8C|rcsb pdb:2INI|rcsb pdb:2K9J|rcsb pdb:2KNC|rcsb pdb:2KV9|rcsb pdb:2L1C|rcsb pdb:2L91|rcsb pdb:2LJD|rcsb pdb:2LJE|rcsb pdb:2LJF|rcsb pdb:2MTP|rcsb pdb:2N9Y|rcsb pdb:2Q6W|rcsb pdb:2RMZ|rcsb pdb:2RN0|rcsb pdb:2VC2|rcsb pdb:2VDK|rcsb pdb:2VDL|rcsb pdb:2VDM|rcsb pdb:2VDN|rcsb pdb:2VDO|rcsb pdb:2VDP|rcsb pdb:2VDQ|rcsb pdb:2VDR|rcsb pdb:3FCS|rcsb pdb:3FCU|rcsb pdb:3IJE|rcsb pdb:3NID|rcsb pdb:3NIF|rcsb pdb:3NIG|rcsb pdb:3T3M|rcsb pdb:3T3P|rcsb pdb:3ZDX|rcsb pdb:3ZDY|rcsb pdb:3ZDZ|rcsb pdb:3ZE0|rcsb pdb:3ZE1|rcsb pdb:3ZE2|rcsb pdb:4CAK|rcsb pdb:4G1E|rcsb pdb:4G1M|rcsb pdb:4MMX|rcsb pdb:4MMY|rcsb pdb:4MMZ|rcsb pdb:4O02|rcsb pdb:4Z7N|rcsb pdb:4Z7O|rcsb pdb:4Z7Q|rcsb pdb:5HDB|rcsb pdb:6AVQ|rcsb pdb:6AVR|rcsb pdb:6AVU|rcsb pdb:6BXB|rcsb pdb:6BXF|rcsb pdb:6BXJ|rcsb pdb:6CKB|rcsb pdb:6MK0|rcsb pdb:6MSL|rcsb pdb:6MSU|rcsb pdb:6NAJ|rcsb pdb:6V4P|reactome:R-HSA-114608|reactome:R-HSA-1566948|reactome:R-HSA-210990|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-445144|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223	-	-	-	figure legend:8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/09/16	2019/10/18	rogid:3XbANVuHd/2LJX6zckEV6xx09mY9606	rogid:EnuaoGdEG3SOqzwmTfH1OwqKuzs9606	intact-crc:0D6380D5FAC065B2|rigid:muFzQWdtegEzDBweICcdwPSPbiI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06756	uniprotkb:P02751	intact:EBI-298282|ensembl:ENSP00000261023|uniprotkb:A0AV67|uniprotkb:Q53SK4|uniprotkb:Q59EB7|uniprotkb:Q6LD15|uniprotkb:D3DPG8|intact:EBI-10984285|uniprotkb:B0LPF4|uniprotkb:B7Z883|uniprotkb:E7EWZ6|uniprotkb:B7ZLX0	intact:EBI-1220319|uniprotkb:Q7Z391|uniprotkb:O95609|uniprotkb:O95610|uniprotkb:Q14312|uniprotkb:Q14325|uniprotkb:Q14326|uniprotkb:Q17RV7|uniprotkb:Q585T2|uniprotkb:Q59EH1|uniprotkb:Q60FE4|uniprotkb:Q68DP8|uniprotkb:Q68DP9|uniprotkb:Q68DT4|uniprotkb:Q6LDP6|uniprotkb:Q6MZU5|uniprotkb:Q6N025|uniprotkb:Q6N0A6|uniprotkb:Q86T27|uniprotkb:Q8IVI8|uniprotkb:Q96KP7|uniprotkb:Q96KP8|uniprotkb:Q96KP9|uniprotkb:Q9H1B8|uniprotkb:Q9HAP3|uniprotkb:Q9UMK2|uniprotkb:Q6MZS0|uniprotkb:B7ZLF0|uniprotkb:E9PE77|uniprotkb:E9PG29|uniprotkb:Q564H7|uniprotkb:Q53S27|ensembl:ENSP00000346839	psi-mi:itav_human(display_long)|uniprotkb:ITGAV(gene name)|psi-mi:ITGAV(display_short)|uniprotkb:VNRA(gene name synonym)|uniprotkb:Vitronectin receptor subunit alpha(gene name synonym)|uniprotkb:MSK8(gene name synonym)|uniprotkb:Vitronectin receptor(gene name synonym)|uniprotkb:VTNR(gene name synonym)	psi-mi:finc_human(display_long)|uniprotkb:FN1(gene name)|psi-mi:FN1(display_short)|uniprotkb:FN(gene name synonym)|uniprotkb:Cold-insoluble globulin(gene name synonym)	psi-mi:"MI:0892"(solid phase assay)	Smith et al. (1990)	pubmed:1694173|imex:IM-19205	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2436358|imex:IM-19205-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000138448(gene)|ensembl:ENST00000261023(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001846"(opsonin binding)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008305"(integrin complex)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0009986"(cell surface)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:1990430"(extracellular matrix protein binding)|go:"GO:2000536"(negative regulation of entry of bacterium into host cell)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|mint:P06756|rcsb pdb:1JV2|rcsb pdb:1L5G|rcsb pdb:1M1X|rcsb pdb:1U8C|rcsb pdb:3IJE|rcsb pdb:4G1E|rcsb pdb:4G1M|rcsb pdb:4MMX|rcsb pdb:4MMY|rcsb pdb:4MMZ|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|rcsb pdb:4O02|rcsb pdb:4UM8|reactome:R-HSA-210990|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-4420097|reactome:R-HSA-445144|reactome:R-HSA-6798695|rcsb pdb:5FFG|rcsb pdb:5FFO|rcsb pdb:5NEM|rcsb pdb:5NER|rcsb pdb:5NET|rcsb pdb:5NEU|rcsb pdb:6AVQ|rcsb pdb:6AVR|rcsb pdb:6AVU|rcsb pdb:6DJP|rcsb pdb:6MK0|rcsb pdb:6MSL|rcsb pdb:6MSU|rcsb pdb:6NAJ|rcsb pdb:6OM1|rcsb pdb:6OM2|rcsb pdb:6UJA|rcsb pdb:6UJB|rcsb pdb:4UM9|rcsb pdb:6UJC|reactome:R-HSA-1236973|reactome:R-HSA-1566948|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034683"(integrin alphav-beta3 complex)|go:"GO:0034684"(integrin alphav-beta5 complex)|go:"GO:0034685"(integrin alphav-beta6 complex)|go:"GO:0034686"(integrin alphav-beta8 complex)|go:"GO:0035579"(specific granule membrane)|go:"GO:0035866"(alphav-beta3 integrin-PKCalpha complex)|go:"GO:0035867"(alphav-beta3 integrin-IGF-1-IGF1R complex)|go:"GO:0035868"(alphav-beta3 integrin-HMGB1 complex)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0038027"(apolipoprotein A-I-mediated signaling pathway)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050748"(negative regulation of lipoprotein metabolic process)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071604"(transforming growth factor beta production)|go:"GO:0085017"(entry into host cell by a symbiont-containing vacuole)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1901388"(regulation of transforming growth factor beta activation)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|refseq:NP_001138472.1|refseq:NP_002201.1|refseq:NP_001138471.1|dip:DIP-31785N	refseq:NP_002017.1|refseq:NP_473375.2|refseq:NP_997639.1|refseq:NP_997641.1|refseq:NP_997643.1|refseq:NP_997647.1|refseq:NP_001293058.1|refseq:NP_001293059.1|refseq:NP_001293060.1|refseq:NP_001293061.1|refseq:XP_005246463.1|dip:DIP-29547N|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009611"(response to wounding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0019899"(enzyme binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0033622"(integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0051087"(chaperone binding)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|ensembl:ENSG00000115414(gene)|ensembl:ENST00000354785(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006953"(acute-phase response)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0072562"(blood microparticle)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|interpro:IPR000083(Fibronectin, type I)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036116|interpro:IPR036943|mint:P02751|rcsb pdb:1E88|rcsb pdb:1E8B|rcsb pdb:1FBR|rcsb pdb:1FNA|rcsb pdb:1FNF|rcsb pdb:1FNH|rcsb pdb:1J8K|rcsb pdb:1O9A|rcsb pdb:1OWW|rcsb pdb:1Q38|rcsb pdb:1QGB|rcsb pdb:1QO6|rcsb pdb:1TTF|rcsb pdb:1TTG|rcsb pdb:2CG6|rcsb pdb:2CG7|rcsb pdb:2CK2|rcsb pdb:2CKU|rcsb pdb:2EC3|rcsb pdb:2FN2|rcsb pdb:2FNB|rcsb pdb:2GEE|rcsb pdb:2H41|rcsb pdb:2H45|rcsb pdb:2HA1|rcsb pdb:2MNU|rcsb pdb:2N1K|rcsb pdb:2OCF|rcsb pdb:2RKY|rcsb pdb:2RKZ|rcsb pdb:2RL0|rcsb pdb:3CAL|rcsb pdb:3EJH|rcsb pdb:3GXE|rcsb pdb:3M7P|rcsb pdb:3MQL|rcsb pdb:3R8Q|rcsb pdb:3T1W|rcsb pdb:3ZRZ|rcsb pdb:4GH7|rcsb pdb:4JE4|rcsb pdb:4JEG|rcsb pdb:4LXO|rcsb pdb:4MMX|rcsb pdb:4MMY|rcsb pdb:4MMZ|rcsb pdb:4PZ5|rcsb pdb:5DC0|rcsb pdb:5DC4|rcsb pdb:5DC9|rcsb pdb:5DFT|rcsb pdb:5J6Z|rcsb pdb:5J7C|rcsb pdb:5M0A|rcsb pdb:5N47|rcsb pdb:5N48|rcsb pdb:6HNF|rcsb pdb:6MFA|rcsb pdb:6MSV|rcsb pdb:6NAJ|rcsb pdb:6XAX|rcsb pdb:6XAY|rcsb pdb:7NWL|reactome:R-HSA-114608|reactome:R-HSA-1474228|reactome:R-HSA-1474244|reactome:R-HSA-1566977|reactome:R-HSA-202733|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-3000171|reactome:R-HSA-3000178|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-381426|reactome:R-HSA-5674135|reactome:R-HSA-6785807|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8874081|reactome:R-HSA-8957275|reactome:R-HSA-9649948|reactome:R-HSA-9656223	-	-	-	figure legend:8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/09/16	2019/10/18	rogid:3XbANVuHd/2LJX6zckEV6xx09mY9606	rogid:4arZu49X8b+dthqaX4DIh59V8h09606	intact-crc:0D6380D5FAC065B2|rigid:muFzQWdtegEzDBweICcdwPSPbiI	false	-	biotin tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06756	uniprotkb:P04275	intact:EBI-298282|ensembl:ENSP00000261023|uniprotkb:A0AV67|uniprotkb:Q53SK4|uniprotkb:Q59EB7|uniprotkb:Q6LD15|uniprotkb:D3DPG8|intact:EBI-10984285|uniprotkb:B0LPF4|uniprotkb:B7Z883|uniprotkb:E7EWZ6|uniprotkb:B7ZLX0	intact:EBI-981819|uniprotkb:Q8TCE8|uniprotkb:Q99806|ensembl:ENSP00000261405	psi-mi:itav_human(display_long)|uniprotkb:ITGAV(gene name)|psi-mi:ITGAV(display_short)|uniprotkb:VNRA(gene name synonym)|uniprotkb:Vitronectin receptor subunit alpha(gene name synonym)|uniprotkb:MSK8(gene name synonym)|uniprotkb:Vitronectin receptor(gene name synonym)|uniprotkb:VTNR(gene name synonym)	psi-mi:vwf_human(display_long)|uniprotkb:VWF(gene name)|psi-mi:VWF(display_short)|uniprotkb:F8VWF(gene name synonym)	psi-mi:"MI:0892"(solid phase assay)	Smith et al. (1990)	pubmed:1694173|imex:IM-19205	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2436366|imex:IM-19205-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000138448(gene)|ensembl:ENST00000261023(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001846"(opsonin binding)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008305"(integrin complex)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0009986"(cell surface)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:1990430"(extracellular matrix protein binding)|go:"GO:2000536"(negative regulation of entry of bacterium into host cell)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|mint:P06756|rcsb pdb:1JV2|rcsb pdb:1L5G|rcsb pdb:1M1X|rcsb pdb:1U8C|rcsb pdb:3IJE|rcsb pdb:4G1E|rcsb pdb:4G1M|rcsb pdb:4MMX|rcsb pdb:4MMY|rcsb pdb:4MMZ|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|rcsb pdb:4O02|rcsb pdb:4UM8|reactome:R-HSA-210990|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-4420097|reactome:R-HSA-445144|reactome:R-HSA-6798695|rcsb pdb:5FFG|rcsb pdb:5FFO|rcsb pdb:5NEM|rcsb pdb:5NER|rcsb pdb:5NET|rcsb pdb:5NEU|rcsb pdb:6AVQ|rcsb pdb:6AVR|rcsb pdb:6AVU|rcsb pdb:6DJP|rcsb pdb:6MK0|rcsb pdb:6MSL|rcsb pdb:6MSU|rcsb pdb:6NAJ|rcsb pdb:6OM1|rcsb pdb:6OM2|rcsb pdb:6UJA|rcsb pdb:6UJB|rcsb pdb:4UM9|rcsb pdb:6UJC|reactome:R-HSA-1236973|reactome:R-HSA-1566948|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034683"(integrin alphav-beta3 complex)|go:"GO:0034684"(integrin alphav-beta5 complex)|go:"GO:0034685"(integrin alphav-beta6 complex)|go:"GO:0034686"(integrin alphav-beta8 complex)|go:"GO:0035579"(specific granule membrane)|go:"GO:0035866"(alphav-beta3 integrin-PKCalpha complex)|go:"GO:0035867"(alphav-beta3 integrin-IGF-1-IGF1R complex)|go:"GO:0035868"(alphav-beta3 integrin-HMGB1 complex)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0038027"(apolipoprotein A-I-mediated signaling pathway)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050748"(negative regulation of lipoprotein metabolic process)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071604"(transforming growth factor beta production)|go:"GO:0085017"(entry into host cell by a symbiont-containing vacuole)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1901388"(regulation of transforming growth factor beta activation)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|refseq:NP_001138472.1|refseq:NP_002201.1|refseq:NP_001138471.1|dip:DIP-31785N	refseq:NP_000543.2|ensembl:ENSG00000110799(gene)|ensembl:ENST00000261405(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007155"(cell adhesion)|go:"GO:0007596"(blood coagulation)|go:"GO:0007599"(hemostasis)|go:"GO:0009611"(response to wounding)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0030168"(platelet activation)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0033093"(Weibel-Palade body)|go:"GO:0042802"(identical protein binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051087"(chaperone binding)|dip:DIP-29667N|reactome:R-HSA-9672391|reactome:R-HSA-9672393|rcsb pdb:5BV8|rcsb pdb:6FWN|rcsb pdb:6N29|rcsb pdb:7KWO|go:"GO:0062023"(collagen-containing extracellular matrix)|reactome:R-HSA-114608|reactome:R-HSA-140837|reactome:R-HSA-216083|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-430116|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-75892|reactome:R-HSA-76009|rcsb pdb:4NT5|reactome:R-HSA-9649948|reactome:R-HSA-9656223|go:"GO:1902533"(positive regulation of intracellular signal transduction)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001846(von Willebrand factor, type D)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR002919(Protease inhibitor I8, cysteine-rich trypsin inhibitor-like)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR014853(Region of unknown function DUF1787)|interpro:IPR032361|interpro:IPR036084|interpro:IPR036465|interpro:IPR037578|mint:P04275|rcsb pdb:1AO3|rcsb pdb:1ATZ|rcsb pdb:1AUQ|rcsb pdb:1FE8|rcsb pdb:1FNS|rcsb pdb:1IJB|rcsb pdb:1IJK|rcsb pdb:1M10|rcsb pdb:1OAK|rcsb pdb:1SQ0|rcsb pdb:1U0N|rcsb pdb:1UEX|rcsb pdb:2ADF|rcsb pdb:2MHP|rcsb pdb:2MHQ|rcsb pdb:3GXB|rcsb pdb:3HXO|rcsb pdb:3HXQ|rcsb pdb:3PPV|go:"GO:0070062"(extracellular exosome)|rcsb pdb:3PPW|rcsb pdb:3PPX|rcsb pdb:3PPY|rcsb pdb:3ZQK|rcsb pdb:4C29|rcsb pdb:4C2A|rcsb pdb:4C2B|rcsb pdb:4DMU	-	-	-	figure legend:8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/09/16	2014/10/16	rogid:3XbANVuHd/2LJX6zckEV6xx09mY9606	rogid:yeGxC2SyyvUZ3hNciww1o8TmY5Q9606	intact-crc:9B95E43080798193|rigid:rjc5WZ0OlDKK7sUlr96wsjI0mOk	false	-	biotin tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06756	uniprotkb:P05106	intact:EBI-298282|ensembl:ENSP00000261023|uniprotkb:A0AV67|uniprotkb:Q53SK4|uniprotkb:Q59EB7|uniprotkb:Q6LD15|uniprotkb:D3DPG8|intact:EBI-10984285|uniprotkb:B0LPF4|uniprotkb:B7Z883|uniprotkb:E7EWZ6|uniprotkb:B7ZLX0	intact:EBI-702847|uniprotkb:A0PJW2|uniprotkb:O15495|uniprotkb:Q12806|uniprotkb:Q13413|uniprotkb:Q14648|uniprotkb:Q16499|uniprotkb:D3DXJ8|ensembl:ENSP00000452786	psi-mi:itav_human(display_long)|uniprotkb:ITGAV(gene name)|psi-mi:ITGAV(display_short)|uniprotkb:VNRA(gene name synonym)|uniprotkb:Vitronectin receptor subunit alpha(gene name synonym)|uniprotkb:MSK8(gene name synonym)|uniprotkb:Vitronectin receptor(gene name synonym)|uniprotkb:VTNR(gene name synonym)	psi-mi:itb3_human(display_long)|uniprotkb:Platelet membrane glycoprotein IIIa(gene name synonym)|uniprotkb:ITGB3(gene name)|psi-mi:ITGB3(display_short)|uniprotkb:GP3A(gene name synonym)	psi-mi:"MI:0892"(solid phase assay)	Smith et al. (1990)	pubmed:1694173|imex:IM-19205	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2436366|imex:IM-19205-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000138448(gene)|ensembl:ENST00000261023(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001846"(opsonin binding)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008305"(integrin complex)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0009986"(cell surface)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:1990430"(extracellular matrix protein binding)|go:"GO:2000536"(negative regulation of entry of bacterium into host cell)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|mint:P06756|rcsb pdb:1JV2|rcsb pdb:1L5G|rcsb pdb:1M1X|rcsb pdb:1U8C|rcsb pdb:3IJE|rcsb pdb:4G1E|rcsb pdb:4G1M|rcsb pdb:4MMX|rcsb pdb:4MMY|rcsb pdb:4MMZ|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|rcsb pdb:4O02|rcsb pdb:4UM8|reactome:R-HSA-210990|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-4420097|reactome:R-HSA-445144|reactome:R-HSA-6798695|rcsb pdb:5FFG|rcsb pdb:5FFO|rcsb pdb:5NEM|rcsb pdb:5NER|rcsb pdb:5NET|rcsb pdb:5NEU|rcsb pdb:6AVQ|rcsb pdb:6AVR|rcsb pdb:6AVU|rcsb pdb:6DJP|rcsb pdb:6MK0|rcsb pdb:6MSL|rcsb pdb:6MSU|rcsb pdb:6NAJ|rcsb pdb:6OM1|rcsb pdb:6OM2|rcsb pdb:6UJA|rcsb pdb:6UJB|rcsb pdb:4UM9|rcsb pdb:6UJC|reactome:R-HSA-1236973|reactome:R-HSA-1566948|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034683"(integrin alphav-beta3 complex)|go:"GO:0034684"(integrin alphav-beta5 complex)|go:"GO:0034685"(integrin alphav-beta6 complex)|go:"GO:0034686"(integrin alphav-beta8 complex)|go:"GO:0035579"(specific granule membrane)|go:"GO:0035866"(alphav-beta3 integrin-PKCalpha complex)|go:"GO:0035867"(alphav-beta3 integrin-IGF-1-IGF1R complex)|go:"GO:0035868"(alphav-beta3 integrin-HMGB1 complex)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0038027"(apolipoprotein A-I-mediated signaling pathway)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050748"(negative regulation of lipoprotein metabolic process)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071604"(transforming growth factor beta production)|go:"GO:0085017"(entry into host cell by a symbiont-containing vacuole)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1901388"(regulation of transforming growth factor beta activation)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|refseq:NP_001138472.1|refseq:NP_002201.1|refseq:NP_001138471.1|dip:DIP-31785N	refseq:NP_000203.2|dip:DIP-304N|ensembl:ENSG00000259207(gene)|ensembl:ENST00000559488(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007596"(blood coagulation)|go:"GO:0008305"(integrin complex)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0014909"(smooth muscle cell migration)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016477"(cell migration)|go:"GO:0019899"(enzyme binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034683"(integrin alphav-beta3 complex)|go:"GO:0035295"(tube development)|go:"GO:0035866"(alphav-beta3 integrin-PKCalpha complex)|go:"GO:0035867"(alphav-beta3 integrin-IGF-1-IGF1R complex)|go:"GO:0035868"(alphav-beta3 integrin-HMGB1 complex)|go:"GO:0038027"(apolipoprotein A-I-mediated signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050748"(negative regulation of lipoprotein metabolic process)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051611"(regulation of serotonin uptake)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071062"(alphav-beta3 integrin-vitronectin complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027068|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|interpro:IPR040622|mint:P05106|rcsb pdb:1JV2|rcsb pdb:1KUP|rcsb pdb:1KUZ|rcsb pdb:1L5G|rcsb pdb:1M1X|rcsb pdb:1M8O|rcsb pdb:1MIZ|rcsb pdb:1MK7|rcsb pdb:1MK9|rcsb pdb:1RN0|rcsb pdb:1S4X|rcsb pdb:1TYE|rcsb pdb:1U8C|rcsb pdb:2INI|rcsb pdb:2K9J|rcsb pdb:2KNC|rcsb pdb:2KV9|rcsb pdb:2L1C|rcsb pdb:2L91|rcsb pdb:2LJD|rcsb pdb:2LJE|rcsb pdb:2LJF|rcsb pdb:2MTP|rcsb pdb:2N9Y|rcsb pdb:2Q6W|rcsb pdb:2RMZ|rcsb pdb:2RN0|rcsb pdb:2VC2|rcsb pdb:2VDK|rcsb pdb:2VDL|rcsb pdb:2VDM|rcsb pdb:2VDN|rcsb pdb:2VDO|rcsb pdb:2VDP|rcsb pdb:2VDQ|rcsb pdb:2VDR|rcsb pdb:3FCS|rcsb pdb:3FCU|rcsb pdb:3IJE|rcsb pdb:3NID|rcsb pdb:3NIF|rcsb pdb:3NIG|rcsb pdb:3T3M|rcsb pdb:3T3P|rcsb pdb:3ZDX|rcsb pdb:3ZDY|rcsb pdb:3ZDZ|rcsb pdb:3ZE0|rcsb pdb:3ZE1|rcsb pdb:3ZE2|rcsb pdb:4CAK|rcsb pdb:4G1E|rcsb pdb:4G1M|rcsb pdb:4MMX|rcsb pdb:4MMY|rcsb pdb:4MMZ|rcsb pdb:4O02|rcsb pdb:4Z7N|rcsb pdb:4Z7O|rcsb pdb:4Z7Q|rcsb pdb:5HDB|rcsb pdb:6AVQ|rcsb pdb:6AVR|rcsb pdb:6AVU|rcsb pdb:6BXB|rcsb pdb:6BXF|rcsb pdb:6BXJ|rcsb pdb:6CKB|rcsb pdb:6MK0|rcsb pdb:6MSL|rcsb pdb:6MSU|rcsb pdb:6NAJ|rcsb pdb:6V4P|reactome:R-HSA-114608|reactome:R-HSA-1566948|reactome:R-HSA-210990|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-445144|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223	-	-	-	figure legend:8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/09/16	2014/10/16	rogid:3XbANVuHd/2LJX6zckEV6xx09mY9606	rogid:EnuaoGdEG3SOqzwmTfH1OwqKuzs9606	intact-crc:9B95E43080798193|rigid:rjc5WZ0OlDKK7sUlr96wsjI0mOk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P18084	uniprotkb:P06756	intact:EBI-1223434|uniprotkb:B0LPF8|uniprotkb:B2RD70|ensembl:ENSP00000296181	intact:EBI-298282|ensembl:ENSP00000261023|uniprotkb:A0AV67|uniprotkb:Q53SK4|uniprotkb:Q59EB7|uniprotkb:Q6LD15|uniprotkb:D3DPG8|intact:EBI-10984285|uniprotkb:B0LPF4|uniprotkb:B7Z883|uniprotkb:E7EWZ6|uniprotkb:B7ZLX0	psi-mi:itb5_human(display_long)|uniprotkb:ITGB5(gene name)|psi-mi:ITGB5(display_short)	psi-mi:itav_human(display_long)|uniprotkb:ITGAV(gene name)|psi-mi:ITGAV(display_short)|uniprotkb:VNRA(gene name synonym)|uniprotkb:Vitronectin receptor subunit alpha(gene name synonym)|uniprotkb:MSK8(gene name synonym)|uniprotkb:Vitronectin receptor(gene name synonym)|uniprotkb:VTNR(gene name synonym)	psi-mi:"MI:0091"(chromatography technology)	Smith et al. (1990)	pubmed:1694173|imex:IM-19205	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2527229|imex:IM-19205-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002204.2|ensembl:ENSG00000082781(gene)|ensembl:ENST00000296181(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034684"(integrin alphav-beta5 complex)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043235"(receptor complex)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090136"(epithelial cell-cell adhesion)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027067|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|interpro:IPR040622|mint:P18084|reactome:R-HSA-1236973|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-445355	ensembl:ENSG00000138448(gene)|ensembl:ENST00000261023(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001846"(opsonin binding)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008305"(integrin complex)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0009986"(cell surface)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:1990430"(extracellular matrix protein binding)|go:"GO:2000536"(negative regulation of entry of bacterium into host cell)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|mint:P06756|rcsb pdb:1JV2|rcsb pdb:1L5G|rcsb pdb:1M1X|rcsb pdb:1U8C|rcsb pdb:3IJE|rcsb pdb:4G1E|rcsb pdb:4G1M|rcsb pdb:4MMX|rcsb pdb:4MMY|rcsb pdb:4MMZ|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|rcsb pdb:4O02|rcsb pdb:4UM8|reactome:R-HSA-210990|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-4420097|reactome:R-HSA-445144|reactome:R-HSA-6798695|rcsb pdb:5FFG|rcsb pdb:5FFO|rcsb pdb:5NEM|rcsb pdb:5NER|rcsb pdb:5NET|rcsb pdb:5NEU|rcsb pdb:6AVQ|rcsb pdb:6AVR|rcsb pdb:6AVU|rcsb pdb:6DJP|rcsb pdb:6MK0|rcsb pdb:6MSL|rcsb pdb:6MSU|rcsb pdb:6NAJ|rcsb pdb:6OM1|rcsb pdb:6OM2|rcsb pdb:6UJA|rcsb pdb:6UJB|rcsb pdb:4UM9|rcsb pdb:6UJC|reactome:R-HSA-1236973|reactome:R-HSA-1566948|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034683"(integrin alphav-beta3 complex)|go:"GO:0034684"(integrin alphav-beta5 complex)|go:"GO:0034685"(integrin alphav-beta6 complex)|go:"GO:0034686"(integrin alphav-beta8 complex)|go:"GO:0035579"(specific granule membrane)|go:"GO:0035866"(alphav-beta3 integrin-PKCalpha complex)|go:"GO:0035867"(alphav-beta3 integrin-IGF-1-IGF1R complex)|go:"GO:0035868"(alphav-beta3 integrin-HMGB1 complex)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0038027"(apolipoprotein A-I-mediated signaling pathway)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050748"(negative regulation of lipoprotein metabolic process)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071604"(transforming growth factor beta production)|go:"GO:0085017"(entry into host cell by a symbiont-containing vacuole)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1901388"(regulation of transforming growth factor beta activation)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|refseq:NP_001138472.1|refseq:NP_002201.1|refseq:NP_001138471.1|dip:DIP-31785N	-	-	-	figure legend:1,2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-placenta)|taxid:9606(Homo sapiens placenta)	-	2009/09/16	2014/10/16	rogid:AKEnIHjRIjtfCHSUvpAkkWZFAu89606	rogid:3XbANVuHd/2LJX6zckEV6xx09mY9606	intact-crc:09EF7276D79FAA3F|rigid:BZZb2+pb9kEgl7jIZFVFUn9gCq4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)