#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q13177 uniprotkb:Q14155 intact:EBI-1045887|uniprotkb:Q13154|uniprotkb:Q6ISC3|ensembl:ENSP00000314067|intact:EBI-28976120 intact:EBI-717515|uniprotkb:B1ALK6|uniprotkb:B1ALK8|uniprotkb:Q3LIA4|uniprotkb:Q5W9H0|uniprotkb:Q6P9G3|uniprotkb:Q6PII2|uniprotkb:Q86W63|uniprotkb:Q8N3M1|ensembl:ENSP00000364893 psi-mi:pak2_human(display_long)|uniprotkb:p21-activated kinase 2(gene name synonym)|uniprotkb:Gamma-PAK(gene name synonym)|uniprotkb:PAK65(gene name synonym)|uniprotkb:S6/H4 kinase(gene name synonym)|uniprotkb:p58(gene name synonym)|uniprotkb:PAK2(gene name)|psi-mi:PAK2(display_short) psi-mi:arhg7_human(display_long)|uniprotkb:PAK-interacting exchange factor beta(gene name synonym)|uniprotkb:Beta-Pix(gene name synonym)|uniprotkb:COOL-1(gene name synonym)|uniprotkb:p85(gene name synonym)|uniprotkb:Nbla10314(orf name)|uniprotkb:ARHGEF7(gene name)|psi-mi:ARHGEF7(display_short)|uniprotkb:COOL1(gene name synonym)|uniprotkb:KIAA0142(gene name synonym)|uniprotkb:P85SPR(gene name synonym)|uniprotkb:PAK3BP(gene name synonym)|uniprotkb:PIXB(gene name synonym) psi-mi:"MI:0405"(competition binding) Za et al. (2006) mint:MINT-7102174|pubmed:16787945|doi:10.1242/jcs.02996 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8553549|mint:MINT-7147251 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000314067|ensembl:ENSG00000180370(gene)|ensembl:ENST00000327134(transcript)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0045296"(cadherin binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0060996"(dendritic spine development)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0150105"(protein localization to cell-cell junction)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001271"(negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|interpro:IPR035064|interpro:IPR035065|interpro:IPR036936|mint:Q13177|rcsb pdb:3PCS|reactome:R-HSA-164944|reactome:R-HSA-202433|reactome:R-HSA-211728|reactome:R-HSA-211733|reactome:R-HSA-211736|reactome:R-HSA-2871796|reactome:R-HSA-389359|reactome:R-HSA-3928664|reactome:R-HSA-399954|reactome:R-HSA-428540|reactome:R-HSA-4420097|reactome:R-HSA-445355|reactome:R-HSA-5621575|reactome:R-HSA-5627123|reactome:R-HSA-5687128|reactome:R-HSA-8950505|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-5218920|refseq:NP_002568.2|refseq:XP_011511172.1|refseq:XP_016861990.1|dip:DIP-38249N|mint:MINT-7147254(identity) refseq:NP_001307782.1|refseq:NP_663788.1|refseq:NP_001106983.1|refseq:NP_001106984.1|refseq:NP_001106985.1|refseq:NP_001307780.1|refseq:NP_001307783.1|refseq:NP_001317526.1|refseq:NP_001317527.1|ensembl:ENSG00000102606(gene)|ensembl:ENST00000375741(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0007030"(Golgi organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0005925"(focal adhesion)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043005"(neuron projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0098794"(postsynapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1904424"(regulation of GTP binding)|go:"GO:1905833"(negative regulation of microtubule nucleation)|go:"GO:2000394"(positive regulation of lamellipodium morphogenesis)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035789|interpro:IPR035899|interpro:IPR036028|interpro:IPR036872|mint:Q14155|rcsb pdb:1BY1|rcsb pdb:1ZSG|rcsb pdb:2L3G|rcsb pdb:5SXP|reactome:R-HSA-182971|reactome:R-HSA-193648|reactome:R-HSA-3928664|reactome:R-HSA-416482|reactome:R-HSA-8980692|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013406|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9619229|dip:DIP-40794N|refseq:NP_003890.1|refseq:XP_016876313.1|refseq:XP_016876314.1|mint:MINT-7147253(identity) - - - comment:homomint|comment:mint|figure legend:f8b|curation depth:mimix curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/06/08 2014/10/16 rogid:BLFG1UZy6GUy26Hd7VDehsIq3/I9606 rogid:0I59YglGXcYP7fFKIAWM6uCZY8Q9606 intact-crc:FCE5DDCC8EF52C5A|rigid:3m4nZ627LE0HzQ6NsLSeVQrQEIw false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y2X7 uniprotkb:Q14155 intact:EBI-466061|uniprotkb:Q86SS0|uniprotkb:Q9BRJ4|uniprotkb:B4DSV3|ensembl:ENSP00000225394|uniprotkb:B4DGU9 intact:EBI-717515|uniprotkb:B1ALK6|uniprotkb:B1ALK8|uniprotkb:Q3LIA4|uniprotkb:Q5W9H0|uniprotkb:Q6P9G3|uniprotkb:Q6PII2|uniprotkb:Q86W63|uniprotkb:Q8N3M1|ensembl:ENSP00000364893 psi-mi:git1_human(display_long)|uniprotkb:GIT1(gene name)|psi-mi:GIT1(display_short)|uniprotkb:G protein-coupled receptor kinase-interactor 1(gene name synonym)|uniprotkb:GRK-interacting protein 1(gene name synonym)|uniprotkb:Cool-associated and tyrosine-phosphorylated protein 1(gene name synonym)|uniprotkb:p95-APP1(gene name synonym) psi-mi:arhg7_human(display_long)|uniprotkb:PAK-interacting exchange factor beta(gene name synonym)|uniprotkb:Beta-Pix(gene name synonym)|uniprotkb:COOL-1(gene name synonym)|uniprotkb:p85(gene name synonym)|uniprotkb:Nbla10314(orf name)|uniprotkb:ARHGEF7(gene name)|psi-mi:ARHGEF7(display_short)|uniprotkb:COOL1(gene name synonym)|uniprotkb:KIAA0142(gene name synonym)|uniprotkb:P85SPR(gene name synonym)|uniprotkb:PAK3BP(gene name synonym)|uniprotkb:PIXB(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Za et al. (2006) mint:MINT-7102174|pubmed:16787945|doi:10.1242/jcs.02996 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8553571|mint:MINT-7147263 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001078923.1|refseq:NP_054749.2|ensembl:ENSG00000108262(gene)|ensembl:ENST00000225394(transcript)|go:"GO:0001957"(intramembranous ossification)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007420"(brain development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0044305"(calyx of Held)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045820"(negative regulation of glycolytic process)|interpro:IPR013724("Spa2 homology (SHD) of GIT")|go:"GO:0046872"(metal ion binding)|interpro:IPR020683|go:"GO:0048013"(ephrin receptor signaling pathway)|interpro:IPR022018|interpro:IPR032352|interpro:IPR036770|interpro:IPR037278|go:"GO:0048666"(neuron development)|go:"GO:0061743"(motor learning)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0098794"(postsynapse)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)|go:"GO:0106015"(negative regulation of inflammatory response to wounding)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR038508|interpro:IPR001164(Arf GTPase activating protein)|mint:Q9Y2X7|interpro:IPR002110(Ankyrin)|reactome:R-HSA-3928664|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9619229|mint:MINT-7147266(identity) refseq:NP_001307782.1|refseq:NP_663788.1|refseq:NP_001106983.1|refseq:NP_001106984.1|refseq:NP_001106985.1|refseq:NP_001307780.1|refseq:NP_001307783.1|refseq:NP_001317526.1|refseq:NP_001317527.1|ensembl:ENSG00000102606(gene)|ensembl:ENST00000375741(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0007030"(Golgi organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0005925"(focal adhesion)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043005"(neuron projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0098794"(postsynapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1904424"(regulation of GTP binding)|go:"GO:1905833"(negative regulation of microtubule nucleation)|go:"GO:2000394"(positive regulation of lamellipodium morphogenesis)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035789|interpro:IPR035899|interpro:IPR036028|interpro:IPR036872|mint:Q14155|rcsb pdb:1BY1|rcsb pdb:1ZSG|rcsb pdb:2L3G|rcsb pdb:5SXP|reactome:R-HSA-182971|reactome:R-HSA-193648|reactome:R-HSA-3928664|reactome:R-HSA-416482|reactome:R-HSA-8980692|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013406|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9619229|dip:DIP-40794N|refseq:NP_003890.1|refseq:XP_016876313.1|refseq:XP_016876314.1|mint:MINT-7147265(identity) - - - comment:homomint|comment:mint|figure legend:f7g|curation depth:mimix curation taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops) - 2009/06/08 2014/10/16 rogid:9POm+EVvD4/BQh6bApnpXCAZyZo9606 rogid:0I59YglGXcYP7fFKIAWM6uCZY8Q9606 intact-crc:1696C8E11DA94FC6|rigid:Nc6G2taURs7A7Z8fnoVdYHuZao0 false flag tag:?-?(MINT-7147272) - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q13177 uniprotkb:Q9Y2X7 intact:EBI-1045887|uniprotkb:Q13154|uniprotkb:Q6ISC3|ensembl:ENSP00000314067|intact:EBI-28976120 intact:EBI-466061|uniprotkb:Q86SS0|uniprotkb:Q9BRJ4|uniprotkb:B4DSV3|ensembl:ENSP00000225394|uniprotkb:B4DGU9 psi-mi:pak2_human(display_long)|uniprotkb:p21-activated kinase 2(gene name synonym)|uniprotkb:Gamma-PAK(gene name synonym)|uniprotkb:PAK65(gene name synonym)|uniprotkb:S6/H4 kinase(gene name synonym)|uniprotkb:p58(gene name synonym)|uniprotkb:PAK2(gene name)|psi-mi:PAK2(display_short) psi-mi:git1_human(display_long)|uniprotkb:GIT1(gene name)|psi-mi:GIT1(display_short)|uniprotkb:G protein-coupled receptor kinase-interactor 1(gene name synonym)|uniprotkb:GRK-interacting protein 1(gene name synonym)|uniprotkb:Cool-associated and tyrosine-phosphorylated protein 1(gene name synonym)|uniprotkb:p95-APP1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Za et al. (2006) mint:MINT-7102174|pubmed:16787945|doi:10.1242/jcs.02996 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8553586|mint:MINT-7147308 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000314067|ensembl:ENSG00000180370(gene)|ensembl:ENST00000327134(transcript)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0045296"(cadherin binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0060996"(dendritic spine development)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0150105"(protein localization to cell-cell junction)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001271"(negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|interpro:IPR035064|interpro:IPR035065|interpro:IPR036936|mint:Q13177|rcsb pdb:3PCS|reactome:R-HSA-164944|reactome:R-HSA-202433|reactome:R-HSA-211728|reactome:R-HSA-211733|reactome:R-HSA-211736|reactome:R-HSA-2871796|reactome:R-HSA-389359|reactome:R-HSA-3928664|reactome:R-HSA-399954|reactome:R-HSA-428540|reactome:R-HSA-4420097|reactome:R-HSA-445355|reactome:R-HSA-5621575|reactome:R-HSA-5627123|reactome:R-HSA-5687128|reactome:R-HSA-8950505|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-5218920|refseq:NP_002568.2|refseq:XP_011511172.1|refseq:XP_016861990.1|dip:DIP-38249N|mint:MINT-7147311(identity) refseq:NP_001078923.1|refseq:NP_054749.2|ensembl:ENSG00000108262(gene)|ensembl:ENST00000225394(transcript)|go:"GO:0001957"(intramembranous ossification)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007420"(brain development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0044305"(calyx of Held)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045820"(negative regulation of glycolytic process)|interpro:IPR013724("Spa2 homology (SHD) of GIT")|go:"GO:0046872"(metal ion binding)|interpro:IPR020683|go:"GO:0048013"(ephrin receptor signaling pathway)|interpro:IPR022018|interpro:IPR032352|interpro:IPR036770|interpro:IPR037278|go:"GO:0048666"(neuron development)|go:"GO:0061743"(motor learning)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0098794"(postsynapse)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)|go:"GO:0106015"(negative regulation of inflammatory response to wounding)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR038508|interpro:IPR001164(Arf GTPase activating protein)|mint:Q9Y2X7|interpro:IPR002110(Ankyrin)|reactome:R-HSA-3928664|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9619229|mint:MINT-7147314(identity) - - - comment:homomint|comment:mint|figure legend:f8c|curation depth:mimix curation taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops) - 2009/06/08 2014/10/16 rogid:BLFG1UZy6GUy26Hd7VDehsIq3/I9606 rogid:9POm+EVvD4/BQh6bApnpXCAZyZo9606 intact-crc:AAAB278B86FE0791|rigid:EOrCgsDOSLqSKqs4D5X0sJFKDkQ false myc tag:?-?(MINT-7147330) flag tag:?-?(MINT-7147346) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13177 uniprotkb:Q14155 intact:EBI-1045887|uniprotkb:Q13154|uniprotkb:Q6ISC3|ensembl:ENSP00000314067|intact:EBI-28976120 intact:EBI-717515|uniprotkb:B1ALK6|uniprotkb:B1ALK8|uniprotkb:Q3LIA4|uniprotkb:Q5W9H0|uniprotkb:Q6P9G3|uniprotkb:Q6PII2|uniprotkb:Q86W63|uniprotkb:Q8N3M1|ensembl:ENSP00000364893 psi-mi:pak2_human(display_long)|uniprotkb:p21-activated kinase 2(gene name synonym)|uniprotkb:Gamma-PAK(gene name synonym)|uniprotkb:PAK65(gene name synonym)|uniprotkb:S6/H4 kinase(gene name synonym)|uniprotkb:p58(gene name synonym)|uniprotkb:PAK2(gene name)|psi-mi:PAK2(display_short) psi-mi:arhg7_human(display_long)|uniprotkb:PAK-interacting exchange factor beta(gene name synonym)|uniprotkb:Beta-Pix(gene name synonym)|uniprotkb:COOL-1(gene name synonym)|uniprotkb:p85(gene name synonym)|uniprotkb:Nbla10314(orf name)|uniprotkb:ARHGEF7(gene name)|psi-mi:ARHGEF7(display_short)|uniprotkb:COOL1(gene name synonym)|uniprotkb:KIAA0142(gene name synonym)|uniprotkb:P85SPR(gene name synonym)|uniprotkb:PAK3BP(gene name synonym)|uniprotkb:PIXB(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Za et al. (2006) mint:MINT-7102174|pubmed:16787945|doi:10.1242/jcs.02996 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8553586|mint:MINT-7147308 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000314067|ensembl:ENSG00000180370(gene)|ensembl:ENST00000327134(transcript)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0045296"(cadherin binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0060996"(dendritic spine development)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0150105"(protein localization to cell-cell junction)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001271"(negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|interpro:IPR035064|interpro:IPR035065|interpro:IPR036936|mint:Q13177|rcsb pdb:3PCS|reactome:R-HSA-164944|reactome:R-HSA-202433|reactome:R-HSA-211728|reactome:R-HSA-211733|reactome:R-HSA-211736|reactome:R-HSA-2871796|reactome:R-HSA-389359|reactome:R-HSA-3928664|reactome:R-HSA-399954|reactome:R-HSA-428540|reactome:R-HSA-4420097|reactome:R-HSA-445355|reactome:R-HSA-5621575|reactome:R-HSA-5627123|reactome:R-HSA-5687128|reactome:R-HSA-8950505|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-5218920|refseq:NP_002568.2|refseq:XP_011511172.1|refseq:XP_016861990.1|dip:DIP-38249N|mint:MINT-7147311(identity) refseq:NP_001307782.1|refseq:NP_663788.1|refseq:NP_001106983.1|refseq:NP_001106984.1|refseq:NP_001106985.1|refseq:NP_001307780.1|refseq:NP_001307783.1|refseq:NP_001317526.1|refseq:NP_001317527.1|ensembl:ENSG00000102606(gene)|ensembl:ENST00000375741(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0007030"(Golgi organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0005925"(focal adhesion)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043005"(neuron projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0098794"(postsynapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1904424"(regulation of GTP binding)|go:"GO:1905833"(negative regulation of microtubule nucleation)|go:"GO:2000394"(positive regulation of lamellipodium morphogenesis)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035789|interpro:IPR035899|interpro:IPR036028|interpro:IPR036872|mint:Q14155|rcsb pdb:1BY1|rcsb pdb:1ZSG|rcsb pdb:2L3G|rcsb pdb:5SXP|reactome:R-HSA-182971|reactome:R-HSA-193648|reactome:R-HSA-3928664|reactome:R-HSA-416482|reactome:R-HSA-8980692|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013406|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9619229|dip:DIP-40794N|refseq:NP_003890.1|refseq:XP_016876313.1|refseq:XP_016876314.1|mint:MINT-7147310(identity) - - - comment:homomint|comment:mint|figure legend:f8c|curation depth:mimix curation taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops) - 2009/06/08 2014/10/16 rogid:BLFG1UZy6GUy26Hd7VDehsIq3/I9606 rogid:0I59YglGXcYP7fFKIAWM6uCZY8Q9606 intact-crc:AAAB278B86FE0791|rigid:EOrCgsDOSLqSKqs4D5X0sJFKDkQ false myc tag:?-?(MINT-7147330) ha tag:?-?(MINT-7147326) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)