#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q8NFA2 uniprotkb:P13498 intact:EBI-7130806|ensembl:ENSP00000380450|uniprotkb:Q86YM1|intact:MINT-7147796|uniprotkb:Q8NFA3|uniprotkb:Q96B73 intact:EBI-986058|uniprotkb:Q14090|uniprotkb:Q9BR72|ensembl:ENSP00000261623 psi-mi:noxo1_human(display_long)|uniprotkb:NOXO1(gene name)|psi-mi:NOXO1(display_short)|uniprotkb:P41NOX(gene name synonym)|uniprotkb:SH3PXD5(gene name synonym)|uniprotkb:Nox-organizing protein 1(gene name synonym)|uniprotkb:Nox organizer 1(gene name synonym)|uniprotkb:NADPH oxidase regulatory protein(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 5(gene name synonym) psi-mi:cy24a_human(display_long)|uniprotkb:p22 phagocyte B-cytochrome(gene name synonym)|uniprotkb:Neutrophil cytochrome b 22 kDa polypeptide(gene name synonym)|uniprotkb:p22-phox(gene name synonym)|uniprotkb:"Cytochrome b(558) alpha chain"(gene name synonym)|uniprotkb:Cytochrome b558 subunit alpha(gene name synonym)|uniprotkb:Superoxide-generating NADPH oxidase light chain subunit(gene name synonym)|uniprotkb:CYBA(gene name)|psi-mi:CYBA(display_short) psi-mi:"MI:0096"(pull down) Nobuhisa et al. (2006) pubmed:16460309|mint:MINT-7103045|doi:10.1042/BJ20051899 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8065890|mint:MINT-7147838 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000196408(gene)|ensembl:ENST00000397280(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060263"(regulation of respiratory burst)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR035758|interpro:IPR036028|interpro:IPR036871|mint:Q8NFA2|rcsb pdb:2L73|reactome:R-HSA-5668599|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013423|reactome:R-HSA-9673324|refseq:NP_751908.1|refseq:NP_751907.1|refseq:NP_001254650.1|refseq:NP_653204.1|refseq:XP_005255156.1|refseq:XP_016878416.1|refseq:XP_016878417.1|mint:MINT-7147840(identity) ensembl:ENSG00000051523(gene)|ensembl:ENST00000261623(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001725"(stress fiber)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003106"(negative regulation of glomerular filtration by angiotensin)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0009055"(electron transfer activity)|go:"GO:0014823"(response to activity)|go:"GO:0014895"(smooth muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016175"("superoxide-generating NAD(P)H oxidase activity")|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017004"(cytochrome complex assembly)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0020037"(heme binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042493"|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0045730"(respiratory burst)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050665"(hydrogen peroxide biosynthetic process)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904044"(response to aldosterone)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904845"(cellular response to L-glutamine)|interpro:IPR007732(Cytochrome b558 alpha-subunit)|mint:P13498|rcsb pdb:1WLP|reactome:R-HSA-1222556|reactome:R-HSA-1236973|reactome:R-HSA-3299685|reactome:R-HSA-4420097|reactome:R-HSA-5668599|reactome:R-HSA-6798695|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9673324|refseq:NP_000092.2|dip:DIP-37650N|mint:MINT-7147853(identity) - comment:mint|comment:homomint - comment:homomint|comment:domino|comment:mint|figure legend:1b 2b|curation depth:mimix curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/06/09 2014/10/16 rogid:QJb5bSxtmpD723eCNye534Zifws9606 rogid:FviZIB2lWLr0GrH9y2gxAA6mgCg9606 intact-crc:FEFFD5C92555F27E|rigid:mebDS+IooV8BwSIKA58XjUYnvx8 false binding-associated region:151-286(MINT-7147942) binding-associated region:151-160(MINT-7147880) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8NFA2 uniprotkb:P13498 intact:EBI-7130806|ensembl:ENSP00000380450|uniprotkb:Q86YM1|intact:MINT-7147796|uniprotkb:Q8NFA3|uniprotkb:Q96B73 intact:EBI-986058|uniprotkb:Q14090|uniprotkb:Q9BR72|ensembl:ENSP00000261623 psi-mi:noxo1_human(display_long)|uniprotkb:NOXO1(gene name)|psi-mi:NOXO1(display_short)|uniprotkb:P41NOX(gene name synonym)|uniprotkb:SH3PXD5(gene name synonym)|uniprotkb:Nox-organizing protein 1(gene name synonym)|uniprotkb:Nox organizer 1(gene name synonym)|uniprotkb:NADPH oxidase regulatory protein(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 5(gene name synonym) psi-mi:cy24a_human(display_long)|uniprotkb:p22 phagocyte B-cytochrome(gene name synonym)|uniprotkb:Neutrophil cytochrome b 22 kDa polypeptide(gene name synonym)|uniprotkb:p22-phox(gene name synonym)|uniprotkb:"Cytochrome b(558) alpha chain"(gene name synonym)|uniprotkb:Cytochrome b558 subunit alpha(gene name synonym)|uniprotkb:Superoxide-generating NADPH oxidase light chain subunit(gene name synonym)|uniprotkb:CYBA(gene name)|psi-mi:CYBA(display_short) psi-mi:"MI:0096"(pull down) Nobuhisa et al. (2006) pubmed:16460309|mint:MINT-7103045|doi:10.1042/BJ20051899 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8065911|mint:MINT-7147990 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000196408(gene)|ensembl:ENST00000397280(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060263"(regulation of respiratory burst)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR035758|interpro:IPR036028|interpro:IPR036871|mint:Q8NFA2|rcsb pdb:2L73|reactome:R-HSA-5668599|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013423|reactome:R-HSA-9673324|refseq:NP_751908.1|refseq:NP_751907.1|refseq:NP_001254650.1|refseq:NP_653204.1|refseq:XP_005255156.1|refseq:XP_016878416.1|refseq:XP_016878417.1|mint:MINT-7147992(identity) ensembl:ENSG00000051523(gene)|ensembl:ENST00000261623(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001725"(stress fiber)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003106"(negative regulation of glomerular filtration by angiotensin)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0009055"(electron transfer activity)|go:"GO:0014823"(response to activity)|go:"GO:0014895"(smooth muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016175"("superoxide-generating NAD(P)H oxidase activity")|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017004"(cytochrome complex assembly)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0020037"(heme binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042493"|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0045730"(respiratory burst)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050665"(hydrogen peroxide biosynthetic process)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904044"(response to aldosterone)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904845"(cellular response to L-glutamine)|interpro:IPR007732(Cytochrome b558 alpha-subunit)|mint:P13498|rcsb pdb:1WLP|reactome:R-HSA-1222556|reactome:R-HSA-1236973|reactome:R-HSA-3299685|reactome:R-HSA-4420097|reactome:R-HSA-5668599|reactome:R-HSA-6798695|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9673324|refseq:NP_000092.2|dip:DIP-37650N|mint:MINT-7147996(identity) - comment:mint|comment:homomint - comment:homomint|comment:domino|comment:mint|figure legend:4a 4b 6|curation depth:mimix curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/06/09 2014/10/16 rogid:QJb5bSxtmpD723eCNye534Zifws9606 rogid:FviZIB2lWLr0GrH9y2gxAA6mgCg9606 intact-crc:58CA2889F1D22B1B|rigid:mebDS+IooV8BwSIKA58XjUYnvx8 false binding-associated region:151-286(MINT-7147993) binding-associated region:151-160(MINT-7147997) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)