#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P14234 uniprotkb:Q9QZE2 intact:EBI-7587024|uniprotkb:Q8BGM0|uniprotkb:Q61404|intact:MINT-85500|ensembl:ENSMUSP00000030693|ensembl:ENSMUSP00000128411 intact:EBI-8040679|uniprotkb:Q8C479|uniprotkb:Q9JMJ3|intact:MINT-263696|ensembl:ENSMUSP00000128473 psi-mi:fgr_mouse(display_long)|uniprotkb:Fgr(gene name)|psi-mi:Fgr(display_short)|uniprotkb:Proto-oncogene c-Fgr(gene name synonym)|uniprotkb:p55-Fgr(gene name synonym) psi-mi:clnk_mouse(display_long)|uniprotkb:Mast cell immunoreceptor signal transducer(gene name synonym)|uniprotkb:Clnk(gene name)|psi-mi:Clnk(display_short)|uniprotkb:Mist(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Sasanuma et al. (2006) pubmed:16439675|mint:MINT-7103053|doi:10.1182/blood-2005-10-4102 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8040697|mint:MINT-7149122 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_034338.3|ensembl:ENSMUSG00000028874(gene)|ensembl:ENSMUST00000030693(transcript)|ensembl:ENSMUST00000171223(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016235"(aggresome)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030282"(bone mineralization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0034988"(Fc-gamma receptor I complex binding)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0050830"(defense response to Gram-positive bacterium)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035693|interpro:IPR036028|interpro:IPR036860|mint:P14234|reactome:R-MMU-2029481|reactome:R-MMU-432142|reactome:R-MMU-6798695|refseq:XP_006538607.1|refseq:XP_006538608.1|mint:MINT-7149125(identity) refseq:XP_011239036.1|refseq:NP_038776.3|refseq:XP_006504037.1|ensembl:ENSMUSG00000039315(gene)|ensembl:ENSMUST00000169819(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0005737"(cytoplasm)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010941"(regulation of cell death)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042629"(mast cell granule)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|mint:Q9QZE2|mint:MINT-7149124(identity) - comment:mint function:"Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT"|comment:mint figure legend:f5b|comment:homomint|comment:mint|curation depth:mimix curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2009/06/10 2014/10/16 rogid:PTSwZB1VVFHv5fmdxyTRBnV8Mek10090 rogid:38yghnd92MMW2BTGaThW9cRqyeg10090 intact-crc:6E6CD3F93D905978|rigid:G8fHaqV/bYZgrCdahCdo2mZqYYg false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P14234 uniprotkb:Q9QZE2 intact:EBI-7587024|uniprotkb:Q8BGM0|uniprotkb:Q61404|intact:MINT-85500|ensembl:ENSMUSP00000030693|ensembl:ENSMUSP00000128411 intact:EBI-8040679|uniprotkb:Q8C479|uniprotkb:Q9JMJ3|intact:MINT-263696|ensembl:ENSMUSP00000128473 psi-mi:fgr_mouse(display_long)|uniprotkb:Fgr(gene name)|psi-mi:Fgr(display_short)|uniprotkb:Proto-oncogene c-Fgr(gene name synonym)|uniprotkb:p55-Fgr(gene name synonym) psi-mi:clnk_mouse(display_long)|uniprotkb:Mast cell immunoreceptor signal transducer(gene name synonym)|uniprotkb:Clnk(gene name)|psi-mi:Clnk(display_short)|uniprotkb:Mist(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sasanuma et al. (2006) pubmed:16439675|mint:MINT-7103053|doi:10.1182/blood-2005-10-4102 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8040835|mint:MINT-7149131 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_034338.3|ensembl:ENSMUSG00000028874(gene)|ensembl:ENSMUST00000030693(transcript)|ensembl:ENSMUST00000171223(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016235"(aggresome)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030282"(bone mineralization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0034988"(Fc-gamma receptor I complex binding)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0050830"(defense response to Gram-positive bacterium)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035693|interpro:IPR036028|interpro:IPR036860|mint:P14234|reactome:R-MMU-2029481|reactome:R-MMU-432142|reactome:R-MMU-6798695|refseq:XP_006538607.1|refseq:XP_006538608.1|mint:MINT-7149135(identity) refseq:XP_011239036.1|refseq:NP_038776.3|refseq:XP_006504037.1|ensembl:ENSMUSG00000039315(gene)|ensembl:ENSMUST00000169819(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0005737"(cytoplasm)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010941"(regulation of cell death)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042629"(mast cell granule)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|mint:Q9QZE2|mint:MINT-7149133(identity) - comment:mint function:"Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT"|comment:mint figure legend:f5c|comment:homomint|comment:mint|curation depth:mimix curation taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops) - 2009/06/10 2014/10/16 rogid:PTSwZB1VVFHv5fmdxyTRBnV8Mek10090 rogid:38yghnd92MMW2BTGaThW9cRqyeg10090 intact-crc:CD23787122C6B06B|rigid:G8fHaqV/bYZgrCdahCdo2mZqYYg false - t7 tag:?-?(MINT-7149139)|binding-associated region:178-182(MINT-7149141) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9QZE2 uniprotkb:P14234 intact:EBI-8040679|uniprotkb:Q8C479|uniprotkb:Q9JMJ3|intact:MINT-263696|ensembl:ENSMUSP00000128473 intact:EBI-7587024|uniprotkb:Q8BGM0|uniprotkb:Q61404|intact:MINT-85500|ensembl:ENSMUSP00000030693|ensembl:ENSMUSP00000128411 psi-mi:clnk_mouse(display_long)|uniprotkb:Mast cell immunoreceptor signal transducer(gene name synonym)|uniprotkb:Clnk(gene name)|psi-mi:Clnk(display_short)|uniprotkb:Mist(gene name synonym) psi-mi:fgr_mouse(display_long)|uniprotkb:Fgr(gene name)|psi-mi:Fgr(display_short)|uniprotkb:Proto-oncogene c-Fgr(gene name synonym)|uniprotkb:p55-Fgr(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sasanuma et al. (2006) pubmed:16439675|mint:MINT-7103053|doi:10.1182/blood-2005-10-4102 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8040871|mint:MINT-7149146 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011239036.1|refseq:NP_038776.3|refseq:XP_006504037.1|ensembl:ENSMUSG00000039315(gene)|ensembl:ENSMUST00000169819(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0005737"(cytoplasm)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010941"(regulation of cell death)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042629"(mast cell granule)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|mint:Q9QZE2|mint:MINT-7149148(identity) refseq:NP_034338.3|ensembl:ENSMUSG00000028874(gene)|ensembl:ENSMUST00000030693(transcript)|ensembl:ENSMUST00000171223(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016235"(aggresome)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030282"(bone mineralization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0034988"(Fc-gamma receptor I complex binding)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0050830"(defense response to Gram-positive bacterium)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035693|interpro:IPR036028|interpro:IPR036860|mint:P14234|reactome:R-MMU-2029481|reactome:R-MMU-432142|reactome:R-MMU-6798695|refseq:XP_006538607.1|refseq:XP_006538608.1|mint:MINT-7149155(identity) - function:"Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT"|comment:mint comment:mint figure legend:f5c|comment:homomint|comment:mint|curation depth:mimix curation taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops) - 2009/06/10 2014/10/16 rogid:38yghnd92MMW2BTGaThW9cRqyeg10090 rogid:PTSwZB1VVFHv5fmdxyTRBnV8Mek10090 intact-crc:418E75ED21444651|rigid:G8fHaqV/bYZgrCdahCdo2mZqYYg false t7 tag:?-?(MINT-7149152) binding-associated region:65-126(MINT-7149161) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)