#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O97758	uniprotkb:Q2TFN9	intact:EBI-6988333|intact:MINT-1778189	intact:EBI-8002398|intact:MINT-7212226	psi-mi:zo1_canlf(display_long)|uniprotkb:TJP1(gene name)|psi-mi:TJP1(display_short)|uniprotkb:ZO1(gene name synonym)|uniprotkb:Zonula occludens protein 1(gene name synonym)|uniprotkb:Zona occludens protein 1(gene name synonym)|uniprotkb:Tight junction protein 1(gene name synonym)	psi-mi:hsp74_canlf(display_long)|uniprotkb:HSPA4(gene name)|psi-mi:HSPA4(display_short)|uniprotkb:APG2(gene name synonym)|uniprotkb:Heat shock 70-related protein APG-2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Tsapara et al. (2006)	pubmed:16407410|mint:MINT-7148034|doi:10.1091/mbc.E05-06-0507	taxid:9615(canlf)|taxid:9615("Canis familiaris (dog)")	taxid:9615(canlf)|taxid:9615("Canis familiaris (dog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8002392|mint:MINT-7212240	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR035597|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005921"(gap junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0009986"(cell surface)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0070160"(tight junction)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0150105"(protein localization to cell-cell junction)|go:"GO:1905605"(positive regulation of blood-brain barrier permeability)|interpro:IPR000906(ZU5)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR005417(Zona occludens protein)|interpro:IPR005418(Zona occludens protein ZO-1)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR027417|refseq:NP_001003140.1|mint:O97758|interpro:IPR036028|interpro:IPR036034|mint:MINT-7212242(identity)	refseq:NP_001041481.1|interpro:IPR018181|interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|mint:Q2TFN9|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|interpro:IPR042052|interpro:IPR043129|mint:MINT-7212243(identity)	-	comment:mint|function:The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions	comment:mint	figure legend:f2a|comment:homomint|comment:mint|curation depth:mimix curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/24	2014/10/16	rogid:ahJn9QpY395wArDFwZ2FwDxf6s89615	rogid:qlD6U7dDxmMEd1/aGDWXmu45viE9615	intact-crc:0B2E583235957E44|rigid:OVc/JESRdinFohNN/f4dAELFw+s	false	binding-associated region:515-583(MINT-7212250)|glutathione s tranferase tag:?-?(MINT-7212247)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q2TFN9	uniprotkb:O97758	intact:EBI-8002398|intact:MINT-7212226	intact:EBI-6988333|intact:MINT-1778189	psi-mi:hsp74_canlf(display_long)|uniprotkb:HSPA4(gene name)|psi-mi:HSPA4(display_short)|uniprotkb:APG2(gene name synonym)|uniprotkb:Heat shock 70-related protein APG-2(gene name synonym)	psi-mi:zo1_canlf(display_long)|uniprotkb:TJP1(gene name)|psi-mi:TJP1(display_short)|uniprotkb:ZO1(gene name synonym)|uniprotkb:Zonula occludens protein 1(gene name synonym)|uniprotkb:Zona occludens protein 1(gene name synonym)|uniprotkb:Tight junction protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Tsapara et al. (2006)	pubmed:16407410|mint:MINT-7148034|doi:10.1091/mbc.E05-06-0507	taxid:9615(canlf)|taxid:9615("Canis familiaris (dog)")	taxid:9615(canlf)|taxid:9615("Canis familiaris (dog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8002442|mint:MINT-7212276	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001041481.1|interpro:IPR018181|interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|mint:Q2TFN9|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|interpro:IPR042052|interpro:IPR043129|mint:MINT-7212285(identity)	interpro:IPR035597|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005921"(gap junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0009986"(cell surface)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0070160"(tight junction)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0150105"(protein localization to cell-cell junction)|go:"GO:1905605"(positive regulation of blood-brain barrier permeability)|interpro:IPR000906(ZU5)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR005417(Zona occludens protein)|interpro:IPR005418(Zona occludens protein ZO-1)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR027417|refseq:NP_001003140.1|mint:O97758|interpro:IPR036028|interpro:IPR036034|mint:MINT-7212278(identity)	-	comment:mint	comment:mint|function:The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions	comment:homomint|comment:mint|figure legend:f3a f3b f3c|curation depth:mimix curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/24	2014/10/16	rogid:qlD6U7dDxmMEd1/aGDWXmu45viE9615	rogid:ahJn9QpY395wArDFwZ2FwDxf6s89615	intact-crc:3FDCD2A2310DA087|rigid:OVc/JESRdinFohNN/f4dAELFw+s	false	binding-associated region:1-419(MINT-7212288)|his tag:?-?(MINT-7212286)	binding-associated region:515-583(MINT-7212281)|glutathione s tranferase tag:?-?(MINT-7212279)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q2TFN9	uniprotkb:O97758	intact:EBI-8002398|intact:MINT-7212226	intact:EBI-6988333|intact:MINT-1778189	psi-mi:hsp74_canlf(display_long)|uniprotkb:HSPA4(gene name)|psi-mi:HSPA4(display_short)|uniprotkb:APG2(gene name synonym)|uniprotkb:Heat shock 70-related protein APG-2(gene name synonym)	psi-mi:zo1_canlf(display_long)|uniprotkb:TJP1(gene name)|psi-mi:TJP1(display_short)|uniprotkb:ZO1(gene name synonym)|uniprotkb:Zonula occludens protein 1(gene name synonym)|uniprotkb:Zona occludens protein 1(gene name synonym)|uniprotkb:Tight junction protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Tsapara et al. (2006)	pubmed:16407410|mint:MINT-7148034|doi:10.1091/mbc.E05-06-0507	taxid:9615(canlf)|taxid:9615("Canis familiaris (dog)")	taxid:9615(canlf)|taxid:9615("Canis familiaris (dog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8002495|mint:MINT-7212254	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001041481.1|interpro:IPR018181|interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|mint:Q2TFN9|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|interpro:IPR042052|interpro:IPR043129|mint:MINT-7212256(identity)	interpro:IPR035597|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005921"(gap junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0009986"(cell surface)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0070160"(tight junction)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0150105"(protein localization to cell-cell junction)|go:"GO:1905605"(positive regulation of blood-brain barrier permeability)|interpro:IPR000906(ZU5)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR005417(Zona occludens protein)|interpro:IPR005418(Zona occludens protein ZO-1)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR027417|refseq:NP_001003140.1|mint:O97758|interpro:IPR036028|interpro:IPR036034|mint:MINT-7212258(identity)	-	comment:mint	comment:mint|function:The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions	comment:homomint|comment:mint|figure legend:f2b f5|curation depth:mimix curation	taxid:286419(dingo)|taxid:286419(Canis lupus dingo)	-	2009/06/24	2014/10/16	rogid:qlD6U7dDxmMEd1/aGDWXmu45viE9615	rogid:ahJn9QpY395wArDFwZ2FwDxf6s89615	intact-crc:1116B534BA21B0BA|rigid:OVc/JESRdinFohNN/f4dAELFw+s	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)