#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P05067	uniprotkb:P21359	intact:EBI-77613|uniprotkb:P09000|uniprotkb:P78438|uniprotkb:Q13764|uniprotkb:Q13778|uniprotkb:Q13793|ensembl:ENSP00000284981|intact:EBI-28985182|uniprotkb:Q6GSC0|uniprotkb:Q8WZ99|uniprotkb:Q9UC33|uniprotkb:Q9UCC8|uniprotkb:Q9UCD1|uniprotkb:Q9UQ58|uniprotkb:Q16011|uniprotkb:Q16014|uniprotkb:Q16019|uniprotkb:Q16020|uniprotkb:Q9BT38|uniprotkb:Q9UCA9|uniprotkb:Q9UCB6|uniprotkb:B4DII8|uniprotkb:B2R5V1|uniprotkb:D3DSD1|uniprotkb:D3DSD2|uniprotkb:D3DSD3	intact:EBI-1172917|uniprotkb:O00662|uniprotkb:Q14284|uniprotkb:Q14930|uniprotkb:Q9UMK3|uniprotkb:Q14931|ensembl:ENSP00000351015	psi-mi:a4_human(display_long)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:nf1_human(display_long)|uniprotkb:NF1(gene name)|psi-mi:NF1(display_short)|uniprotkb:Neurofibromatosis-related protein NF-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	De et al. (2006)	pubmed:16374483|imex:IM-20355	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2431746|imex:IM-20355-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0097645"(amylin binding)|go:"GO:0098815"(modulation of excitatory postsynaptic potential)|go:"GO:0106003"(amyloid-beta complex)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:1900122"(positive regulation of receptor binding)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1900221"(regulation of amyloid-beta clearance)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903048"(regulation of acetylcholine-gated cation channel activity)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904022"(positive regulation of G protein-coupled receptor internalization)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043235"(receptor complex)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044304"(main axon)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0046914"(transition metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|ensembl:ENST00000346798(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|ensembl:ENSG00000142192(gene)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001878"(response to yeast)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001967"(suckling behavior)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007155"(cell adhesion)|go:"GO:0007176"(regulation of epidermal growth factor-activated receptor activity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007611"(learning or memory)|go:"GO:0006897"(endocytosis)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007617"(mating behavior)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008088"(axo-dendritic transport)|go:"GO:0008201"(heparin binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0009987"(cellular process)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048669"(collateral sprouting in absence of injury)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050808"(synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050867"(positive regulation of cell activation)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0050890"(cognition)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051124"(synaptic assembly at neuromuscular junction)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0010823"(negative regulation of mitochondrion organization)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0014005"(microglia development)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016199"(axon midline choice point recognition)|go:"GO:0016322"(neuron remodeling)|go:"GO:0016358"(dendrite development)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019899"(enzyme binding)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030424"(axon)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0030549"(acetylcholine receptor activator activity)|go:"GO:0030900"(forebrain development)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031175"(neuron projection development)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034363"(intermediate-density lipoprotein particle)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0031904"(endosome lumen)|go:"GO:0051233"(spindle midzone)|go:"GO:0061903"(positive regulation of 1-phosphatidylinositol-3-kinase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0070206"(protein trimerization)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070381"(endosome to plasma membrane transport vesicle)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071874"(cellular response to norepinephrine stimulus)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0097449"(astrocyte projection)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051425"(PTB domain binding)|go:"GO:0051563"(smooth endoplasmic reticulum calcium ion homeostasis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:1904399"(heparan sulfate binding)|rcsb pdb:2LZ4|rcsb pdb:2M4J|rcsb pdb:2M9R|rcsb pdb:2M9S|rcsb pdb:2MGT|rcsb pdb:2MJ1|rcsb pdb:2MPZ|rcsb pdb:2MVX|rcsb pdb:2MXU|rcsb pdb:2NAO|interpro:IPR036880|interpro:IPR037071|rcsb pdb:2OTK|rcsb pdb:2R0W|rcsb pdb:2WK3|rcsb pdb:2Y29|mint:P05067|rcsb pdb:1AAP|rcsb pdb:1AMB|rcsb pdb:1AMC|rcsb pdb:1AML|rcsb pdb:1BA4|rcsb pdb:1BA6|rcsb pdb:1BJB|rcsb pdb:1BJC|rcsb pdb:1BRC|rcsb pdb:1CA0|rcsb pdb:1HZ3|rcsb pdb:1IYT|rcsb pdb:1MWP|rcsb pdb:1OWT|rcsb pdb:1QCM|rcsb pdb:1QWP|rcsb pdb:1QXC|rcsb pdb:1QYT|rcsb pdb:1TAW|rcsb pdb:1TKN|rcsb pdb:1UO7|rcsb pdb:1UO8|rcsb pdb:1UOA|rcsb pdb:1UOI|rcsb pdb:1X11|rcsb pdb:1Z0Q|rcsb pdb:1ZE7|rcsb pdb:1ZE9|rcsb pdb:1ZJD|rcsb pdb:2BEG|rcsb pdb:2BOM|rcsb pdb:2BP4|rcsb pdb:2FJZ|rcsb pdb:2FK1|rcsb pdb:2FK2|rcsb pdb:2FK3|rcsb pdb:2FKL|rcsb pdb:2FMA|rcsb pdb:2G47|rcsb pdb:2IPU|rcsb pdb:2LFM|rcsb pdb:2LLM|rcsb pdb:2LMN|rcsb pdb:2LMO|rcsb pdb:2LMP|rcsb pdb:2LMQ|rcsb pdb:2LNQ|rcsb pdb:2LOH|rcsb pdb:2LP1|rcsb pdb:2LZ3|rcsb pdb:2Y2A|rcsb pdb:2Y3J|rcsb pdb:2Y3K|rcsb pdb:2Y3L|rcsb pdb:3AYU|rcsb pdb:3BAE|rcsb pdb:3BKJ|rcsb pdb:3DXC|rcsb pdb:3DXD|rcsb pdb:3DXE|rcsb pdb:3GCI|rcsb pdb:3IFL|rcsb pdb:3IFN|rcsb pdb:3IFO|rcsb pdb:3IFP|rcsb pdb:3JQ5|rcsb pdb:3JQL|rcsb pdb:3JTI|rcsb pdb:3KTM|rcsb pdb:3L33|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904591"(positive regulation of protein import)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:1905893"(positive regulation of cellular response to thapsigargin)|go:"GO:1905896"(positive regulation of cellular response to tunicamycin)|go:"GO:1905898"(positive regulation of response to endoplasmic reticulum stress)|go:"GO:1905906"(regulation of amyloid fibril formation)|go:"GO:1905908"(positive regulation of amyloid fibril formation)|go:"GO:1905945"(regulation of response to calcium ion)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990535"(neuron projection maintenance)|go:"GO:1990761"(growth cone lamellipodium)|go:"GO:1990777"(lipoprotein particle)|go:"GO:1990812"(growth cone filopodium)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR002223(Proteinase inhibitor I2, Kunitz metazoa)|interpro:IPR008154(Amyloidogenic glycoprotein, extracellular)|interpro:IPR008155(Amyloidogenic glycoprotein, core)|interpro:IPR011178(Amyloidogenic glycoprotein, copper-binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013803(Amyloidogenic glycoprotein, amyloid-beta peptide)|interpro:IPR015849(Amyloidogenic glycoprotein, heparin-binding)|interpro:IPR019543|interpro:IPR019744|interpro:IPR019745|interpro:IPR020901|interpro:IPR024329|interpro:IPR028866|interpro:IPR036176|interpro:IPR036454|interpro:IPR036669|rcsb pdb:5HOY|rcsb pdb:5KK3|rcsb pdb:5LFY|rcsb pdb:5LV0|rcsb pdb:5MY4|rcsb pdb:5MYO|rcsb pdb:5MYX|rcsb pdb:5ONP|rcsb pdb:5ONQ|rcsb pdb:5OQV|rcsb pdb:5TXD|rcsb pdb:5VOS|rcsb pdb:5VZY|rcsb pdb:5W3P|rcsb pdb:6CO3|rcsb pdb:6GFI|rcsb pdb:6ITU|rcsb pdb:6IYC|rcsb pdb:6NB9|rcsb pdb:6O4J|rcsb pdb:6OC9|rcsb pdb:6OIZ|rcsb pdb:6RHY|rcsb pdb:6SHS|rcsb pdb:6SZF|rcsb pdb:6TI5|rcsb pdb:6TI6|rcsb pdb:6TI7|rcsb pdb:6W0O|rcsb pdb:6WXM|rcsb pdb:6YHF|rcsb pdb:6YHI|rcsb pdb:6YHO|rcsb pdb:6YHP|rcsb pdb:6YHX|rcsb pdb:7B3J|rcsb pdb:7B3K|rcsb pdb:7JXN|rcsb pdb:7JXO|rcsb pdb:7O1Q|reactome:R-HSA-114608|reactome:R-HSA-3000178|reactome:R-HSA-381426|reactome:R-HSA-416476|reactome:R-HSA-418594|reactome:R-HSA-432720|reactome:R-HSA-444473|reactome:R-HSA-445989|reactome:R-HSA-844456|reactome:R-HSA-879415|reactome:R-HSA-8862803|reactome:R-HSA-8957275|reactome:R-HSA-933542|reactome:R-HSA-9609523|reactome:R-HSA-9660826|reactome:R-HSA-977225|rcsb pdb:5AMB|rcsb pdb:5BUO|rcsb pdb:5C67|rcsb pdb:5CSZ|rcsb pdb:5HOW|rcsb pdb:5HOX|rcsb pdb:3L81|rcsb pdb:3MOQ|rcsb pdb:3MXC|rcsb pdb:3MXY|rcsb pdb:3NYJ|rcsb pdb:3NYL|rcsb pdb:3OVJ|rcsb pdb:3OW9|rcsb pdb:3PZZ|rcsb pdb:3Q2X|rcsb pdb:3SV1|rcsb pdb:3U0T|rcsb pdb:3UMH|rcsb pdb:3UMI|rcsb pdb:3UMK|rcsb pdb:4HIX|rcsb pdb:4JFN|rcsb pdb:4M1C|rcsb pdb:4MDR|rcsb pdb:4MVI|rcsb pdb:4MVK|rcsb pdb:4MVL|rcsb pdb:4NGE|rcsb pdb:4OJF|rcsb pdb:4ONF|rcsb pdb:4ONG|rcsb pdb:4PQD|rcsb pdb:4PWQ|rcsb pdb:4XXD|rcsb pdb:5AEF|rcsb pdb:5AM8|refseq:NP_000475.1|refseq:NP_001129601.1|refseq:NP_001129602.1|refseq:NP_001191230.1|refseq:NP_001191231.1|refseq:NP_001191232.1|refseq:NP_958816.1|refseq:NP_958817.1|ensembl:ENSP00000284981|ensembl:ENST00000348990|ensembl:ENSP00000345463|ensembl:ENST00000354192|ensembl:ENSP00000346129|ensembl:ENST00000357903|ensembl:ENSP00000350578|ensembl:ENST00000358918|ensembl:ENSP00000351796|ensembl:ENST00000440126|ensembl:ENSP00000387483|refseq:NP_001129488.1|refseq:NP_001129603.1|dip:DIP-574N	refseq:NP_000258.1|refseq:NP_001035957.1|refseq:NP_001121619.1|ensembl:ENSG00000196712(gene)|ensembl:ENST00000358273(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001656"(metanephros development)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001889"(liver development)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007154"(cell communication)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007420"(brain development)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0008542"(visual learning)|go:"GO:0014044"(Schwann cell development)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0021510"(spinal cord development)|go:"GO:0021897"(forebrain astrocyte development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0042060"(wound healing)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043473"(pigmentation)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043535"(regulation of blood vessel endothelial cell migration)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045685"(regulation of glial cell differentiation)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0050890"(cognition)|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR023152|interpro:IPR036865|interpro:IPR039360|mint:P21359|rcsb pdb:1NF1|rcsb pdb:2E2X|rcsb pdb:3P7Z|rcsb pdb:3PEG|rcsb pdb:3PG7|rcsb pdb:6OB2|rcsb pdb:6OB3|rcsb pdb:6V65|rcsb pdb:6V6F|reactome:R-HSA-5658442|reactome:R-HSA-6802953|rcsb pdb:2D4Q	-	-	-	figure legend:Figure 1|comment:"The authors comment that although bands corresponding to the immature (110kDa) and mature (130kDa) APP were observed in the silver stain of immunoprecipte using NF1 antibody. Following western blotting the band detected by the CT15 antibody to APP was intermediate between the mature and immature species. The reason for this remains unclear."|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2009/09/01	2014/10/16	rogid:HatR8w8+mNjtjr7s5+bAwaStpmk9606	rogid:9/AAe+70biVtuhfi0XOaUUkg4D09606	intact-crc:8914F3E75AC1AC8E|rigid:gVvuC54Yl/+xT9g/wsHjUQq8XT0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P05067	uniprotkb:P21359	intact:EBI-77613|uniprotkb:P09000|uniprotkb:P78438|uniprotkb:Q13764|uniprotkb:Q13778|uniprotkb:Q13793|ensembl:ENSP00000284981|intact:EBI-28985182|uniprotkb:Q6GSC0|uniprotkb:Q8WZ99|uniprotkb:Q9UC33|uniprotkb:Q9UCC8|uniprotkb:Q9UCD1|uniprotkb:Q9UQ58|uniprotkb:Q16011|uniprotkb:Q16014|uniprotkb:Q16019|uniprotkb:Q16020|uniprotkb:Q9BT38|uniprotkb:Q9UCA9|uniprotkb:Q9UCB6|uniprotkb:B4DII8|uniprotkb:B2R5V1|uniprotkb:D3DSD1|uniprotkb:D3DSD2|uniprotkb:D3DSD3	intact:EBI-1172917|uniprotkb:O00662|uniprotkb:Q14284|uniprotkb:Q14930|uniprotkb:Q9UMK3|uniprotkb:Q14931|ensembl:ENSP00000351015	psi-mi:a4_human(display_long)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:nf1_human(display_long)|uniprotkb:NF1(gene name)|psi-mi:NF1(display_short)|uniprotkb:Neurofibromatosis-related protein NF-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	De et al. (2006)	pubmed:16374483|imex:IM-20355	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2431752|imex:IM-20355-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0097645"(amylin binding)|go:"GO:0098815"(modulation of excitatory postsynaptic potential)|go:"GO:0106003"(amyloid-beta complex)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:1900122"(positive regulation of receptor binding)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1900221"(regulation of amyloid-beta clearance)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903048"(regulation of acetylcholine-gated cation channel activity)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904022"(positive regulation of G protein-coupled receptor internalization)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043235"(receptor complex)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044304"(main axon)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0046914"(transition metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|ensembl:ENST00000346798(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|ensembl:ENSG00000142192(gene)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001878"(response to yeast)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001967"(suckling behavior)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007155"(cell adhesion)|go:"GO:0007176"(regulation of epidermal growth factor-activated receptor activity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007611"(learning or memory)|go:"GO:0006897"(endocytosis)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007617"(mating behavior)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008088"(axo-dendritic transport)|go:"GO:0008201"(heparin binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0009987"(cellular process)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048669"(collateral sprouting in absence of injury)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050808"(synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050867"(positive regulation of cell activation)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0050890"(cognition)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051124"(synaptic assembly at neuromuscular junction)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0010823"(negative regulation of mitochondrion organization)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0014005"(microglia development)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016199"(axon midline choice point recognition)|go:"GO:0016322"(neuron remodeling)|go:"GO:0016358"(dendrite development)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019899"(enzyme binding)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030424"(axon)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0030549"(acetylcholine receptor activator activity)|go:"GO:0030900"(forebrain development)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031175"(neuron projection development)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034363"(intermediate-density lipoprotein particle)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0031904"(endosome lumen)|go:"GO:0051233"(spindle midzone)|go:"GO:0061903"(positive regulation of 1-phosphatidylinositol-3-kinase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0070206"(protein trimerization)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070381"(endosome to plasma membrane transport vesicle)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071874"(cellular response to norepinephrine stimulus)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0097449"(astrocyte projection)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051425"(PTB domain binding)|go:"GO:0051563"(smooth endoplasmic reticulum calcium ion homeostasis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:1904399"(heparan sulfate binding)|rcsb pdb:2LZ4|rcsb pdb:2M4J|rcsb pdb:2M9R|rcsb pdb:2M9S|rcsb pdb:2MGT|rcsb pdb:2MJ1|rcsb pdb:2MPZ|rcsb pdb:2MVX|rcsb pdb:2MXU|rcsb pdb:2NAO|interpro:IPR036880|interpro:IPR037071|rcsb pdb:2OTK|rcsb pdb:2R0W|rcsb pdb:2WK3|rcsb pdb:2Y29|mint:P05067|rcsb pdb:1AAP|rcsb pdb:1AMB|rcsb pdb:1AMC|rcsb pdb:1AML|rcsb pdb:1BA4|rcsb pdb:1BA6|rcsb pdb:1BJB|rcsb pdb:1BJC|rcsb pdb:1BRC|rcsb pdb:1CA0|rcsb pdb:1HZ3|rcsb pdb:1IYT|rcsb pdb:1MWP|rcsb pdb:1OWT|rcsb pdb:1QCM|rcsb pdb:1QWP|rcsb pdb:1QXC|rcsb pdb:1QYT|rcsb pdb:1TAW|rcsb pdb:1TKN|rcsb pdb:1UO7|rcsb pdb:1UO8|rcsb pdb:1UOA|rcsb pdb:1UOI|rcsb pdb:1X11|rcsb pdb:1Z0Q|rcsb pdb:1ZE7|rcsb pdb:1ZE9|rcsb pdb:1ZJD|rcsb pdb:2BEG|rcsb pdb:2BOM|rcsb pdb:2BP4|rcsb pdb:2FJZ|rcsb pdb:2FK1|rcsb pdb:2FK2|rcsb pdb:2FK3|rcsb pdb:2FKL|rcsb pdb:2FMA|rcsb pdb:2G47|rcsb pdb:2IPU|rcsb pdb:2LFM|rcsb pdb:2LLM|rcsb pdb:2LMN|rcsb pdb:2LMO|rcsb pdb:2LMP|rcsb pdb:2LMQ|rcsb pdb:2LNQ|rcsb pdb:2LOH|rcsb pdb:2LP1|rcsb pdb:2LZ3|rcsb pdb:2Y2A|rcsb pdb:2Y3J|rcsb pdb:2Y3K|rcsb pdb:2Y3L|rcsb pdb:3AYU|rcsb pdb:3BAE|rcsb pdb:3BKJ|rcsb pdb:3DXC|rcsb pdb:3DXD|rcsb pdb:3DXE|rcsb pdb:3GCI|rcsb pdb:3IFL|rcsb pdb:3IFN|rcsb pdb:3IFO|rcsb pdb:3IFP|rcsb pdb:3JQ5|rcsb pdb:3JQL|rcsb pdb:3JTI|rcsb pdb:3KTM|rcsb pdb:3L33|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904591"(positive regulation of protein import)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:1905893"(positive regulation of cellular response to thapsigargin)|go:"GO:1905896"(positive regulation of cellular response to tunicamycin)|go:"GO:1905898"(positive regulation of response to endoplasmic reticulum stress)|go:"GO:1905906"(regulation of amyloid fibril formation)|go:"GO:1905908"(positive regulation of amyloid fibril formation)|go:"GO:1905945"(regulation of response to calcium ion)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990535"(neuron projection maintenance)|go:"GO:1990761"(growth cone lamellipodium)|go:"GO:1990777"(lipoprotein particle)|go:"GO:1990812"(growth cone filopodium)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR002223(Proteinase inhibitor I2, Kunitz metazoa)|interpro:IPR008154(Amyloidogenic glycoprotein, extracellular)|interpro:IPR008155(Amyloidogenic glycoprotein, core)|interpro:IPR011178(Amyloidogenic glycoprotein, copper-binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013803(Amyloidogenic glycoprotein, amyloid-beta peptide)|interpro:IPR015849(Amyloidogenic glycoprotein, heparin-binding)|interpro:IPR019543|interpro:IPR019744|interpro:IPR019745|interpro:IPR020901|interpro:IPR024329|interpro:IPR028866|interpro:IPR036176|interpro:IPR036454|interpro:IPR036669|rcsb pdb:5HOY|rcsb pdb:5KK3|rcsb pdb:5LFY|rcsb pdb:5LV0|rcsb pdb:5MY4|rcsb pdb:5MYO|rcsb pdb:5MYX|rcsb pdb:5ONP|rcsb pdb:5ONQ|rcsb pdb:5OQV|rcsb pdb:5TXD|rcsb pdb:5VOS|rcsb pdb:5VZY|rcsb pdb:5W3P|rcsb pdb:6CO3|rcsb pdb:6GFI|rcsb pdb:6ITU|rcsb pdb:6IYC|rcsb pdb:6NB9|rcsb pdb:6O4J|rcsb pdb:6OC9|rcsb pdb:6OIZ|rcsb pdb:6RHY|rcsb pdb:6SHS|rcsb pdb:6SZF|rcsb pdb:6TI5|rcsb pdb:6TI6|rcsb pdb:6TI7|rcsb pdb:6W0O|rcsb pdb:6WXM|rcsb pdb:6YHF|rcsb pdb:6YHI|rcsb pdb:6YHO|rcsb pdb:6YHP|rcsb pdb:6YHX|rcsb pdb:7B3J|rcsb pdb:7B3K|rcsb pdb:7JXN|rcsb pdb:7JXO|rcsb pdb:7O1Q|reactome:R-HSA-114608|reactome:R-HSA-3000178|reactome:R-HSA-381426|reactome:R-HSA-416476|reactome:R-HSA-418594|reactome:R-HSA-432720|reactome:R-HSA-444473|reactome:R-HSA-445989|reactome:R-HSA-844456|reactome:R-HSA-879415|reactome:R-HSA-8862803|reactome:R-HSA-8957275|reactome:R-HSA-933542|reactome:R-HSA-9609523|reactome:R-HSA-9660826|reactome:R-HSA-977225|rcsb pdb:5AMB|rcsb pdb:5BUO|rcsb pdb:5C67|rcsb pdb:5CSZ|rcsb pdb:5HOW|rcsb pdb:5HOX|rcsb pdb:3L81|rcsb pdb:3MOQ|rcsb pdb:3MXC|rcsb pdb:3MXY|rcsb pdb:3NYJ|rcsb pdb:3NYL|rcsb pdb:3OVJ|rcsb pdb:3OW9|rcsb pdb:3PZZ|rcsb pdb:3Q2X|rcsb pdb:3SV1|rcsb pdb:3U0T|rcsb pdb:3UMH|rcsb pdb:3UMI|rcsb pdb:3UMK|rcsb pdb:4HIX|rcsb pdb:4JFN|rcsb pdb:4M1C|rcsb pdb:4MDR|rcsb pdb:4MVI|rcsb pdb:4MVK|rcsb pdb:4MVL|rcsb pdb:4NGE|rcsb pdb:4OJF|rcsb pdb:4ONF|rcsb pdb:4ONG|rcsb pdb:4PQD|rcsb pdb:4PWQ|rcsb pdb:4XXD|rcsb pdb:5AEF|rcsb pdb:5AM8|refseq:NP_000475.1|refseq:NP_001129601.1|refseq:NP_001129602.1|refseq:NP_001191230.1|refseq:NP_001191231.1|refseq:NP_001191232.1|refseq:NP_958816.1|refseq:NP_958817.1|ensembl:ENSP00000284981|ensembl:ENST00000348990|ensembl:ENSP00000345463|ensembl:ENST00000354192|ensembl:ENSP00000346129|ensembl:ENST00000357903|ensembl:ENSP00000350578|ensembl:ENST00000358918|ensembl:ENSP00000351796|ensembl:ENST00000440126|ensembl:ENSP00000387483|refseq:NP_001129488.1|refseq:NP_001129603.1|dip:DIP-574N	refseq:NP_000258.1|refseq:NP_001035957.1|refseq:NP_001121619.1|ensembl:ENSG00000196712(gene)|ensembl:ENST00000358273(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001656"(metanephros development)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001889"(liver development)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007154"(cell communication)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007420"(brain development)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0008542"(visual learning)|go:"GO:0014044"(Schwann cell development)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0021510"(spinal cord development)|go:"GO:0021897"(forebrain astrocyte development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0042060"(wound healing)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043473"(pigmentation)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043535"(regulation of blood vessel endothelial cell migration)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045685"(regulation of glial cell differentiation)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0050890"(cognition)|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR023152|interpro:IPR036865|interpro:IPR039360|mint:P21359|rcsb pdb:1NF1|rcsb pdb:2E2X|rcsb pdb:3P7Z|rcsb pdb:3PEG|rcsb pdb:3PG7|rcsb pdb:6OB2|rcsb pdb:6OB3|rcsb pdb:6V65|rcsb pdb:6V6F|reactome:R-HSA-5658442|reactome:R-HSA-6802953|rcsb pdb:2D4Q	-	-	-	figure legend:Figure 1|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2009/09/01	2014/10/16	rogid:HatR8w8+mNjtjr7s5+bAwaStpmk9606	rogid:9/AAe+70biVtuhfi0XOaUUkg4D09606	intact-crc:D087EF15D672C295|rigid:gVvuC54Yl/+xT9g/wsHjUQq8XT0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P05067	uniprotkb:P21359	intact:EBI-77613|uniprotkb:P09000|uniprotkb:P78438|uniprotkb:Q13764|uniprotkb:Q13778|uniprotkb:Q13793|ensembl:ENSP00000284981|intact:EBI-28985182|uniprotkb:Q6GSC0|uniprotkb:Q8WZ99|uniprotkb:Q9UC33|uniprotkb:Q9UCC8|uniprotkb:Q9UCD1|uniprotkb:Q9UQ58|uniprotkb:Q16011|uniprotkb:Q16014|uniprotkb:Q16019|uniprotkb:Q16020|uniprotkb:Q9BT38|uniprotkb:Q9UCA9|uniprotkb:Q9UCB6|uniprotkb:B4DII8|uniprotkb:B2R5V1|uniprotkb:D3DSD1|uniprotkb:D3DSD2|uniprotkb:D3DSD3	intact:EBI-1172917|uniprotkb:O00662|uniprotkb:Q14284|uniprotkb:Q14930|uniprotkb:Q9UMK3|uniprotkb:Q14931|ensembl:ENSP00000351015	psi-mi:a4_human(display_long)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:nf1_human(display_long)|uniprotkb:NF1(gene name)|psi-mi:NF1(display_short)|uniprotkb:Neurofibromatosis-related protein NF-1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	De et al. (2006)	pubmed:16374483|imex:IM-20355	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2432247|imex:IM-20355-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0097645"(amylin binding)|go:"GO:0098815"(modulation of excitatory postsynaptic potential)|go:"GO:0106003"(amyloid-beta complex)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:1900122"(positive regulation of receptor binding)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1900221"(regulation of amyloid-beta clearance)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903048"(regulation of acetylcholine-gated cation channel activity)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904022"(positive regulation of G protein-coupled receptor internalization)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043235"(receptor complex)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044304"(main axon)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0046914"(transition metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|ensembl:ENST00000346798(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|ensembl:ENSG00000142192(gene)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001878"(response to yeast)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001967"(suckling behavior)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007155"(cell adhesion)|go:"GO:0007176"(regulation of epidermal growth factor-activated receptor activity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007611"(learning or memory)|go:"GO:0006897"(endocytosis)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007617"(mating behavior)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008088"(axo-dendritic transport)|go:"GO:0008201"(heparin binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0009987"(cellular process)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048669"(collateral sprouting in absence of injury)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050808"(synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050867"(positive regulation of cell activation)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0050890"(cognition)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051124"(synaptic assembly at neuromuscular junction)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0010823"(negative regulation of mitochondrion organization)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0014005"(microglia development)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016199"(axon midline choice point recognition)|go:"GO:0016322"(neuron remodeling)|go:"GO:0016358"(dendrite development)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019899"(enzyme binding)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030424"(axon)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0030549"(acetylcholine receptor activator activity)|go:"GO:0030900"(forebrain development)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031175"(neuron projection development)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034363"(intermediate-density lipoprotein particle)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0031904"(endosome lumen)|go:"GO:0051233"(spindle midzone)|go:"GO:0061903"(positive regulation of 1-phosphatidylinositol-3-kinase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0070206"(protein trimerization)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070381"(endosome to plasma membrane transport vesicle)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071874"(cellular response to norepinephrine stimulus)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0097449"(astrocyte projection)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051425"(PTB domain binding)|go:"GO:0051563"(smooth endoplasmic reticulum calcium ion homeostasis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:1904399"(heparan sulfate binding)|rcsb pdb:2LZ4|rcsb pdb:2M4J|rcsb pdb:2M9R|rcsb pdb:2M9S|rcsb pdb:2MGT|rcsb pdb:2MJ1|rcsb pdb:2MPZ|rcsb pdb:2MVX|rcsb pdb:2MXU|rcsb pdb:2NAO|interpro:IPR036880|interpro:IPR037071|rcsb pdb:2OTK|rcsb pdb:2R0W|rcsb pdb:2WK3|rcsb pdb:2Y29|mint:P05067|rcsb pdb:1AAP|rcsb pdb:1AMB|rcsb pdb:1AMC|rcsb pdb:1AML|rcsb pdb:1BA4|rcsb pdb:1BA6|rcsb pdb:1BJB|rcsb pdb:1BJC|rcsb pdb:1BRC|rcsb pdb:1CA0|rcsb pdb:1HZ3|rcsb pdb:1IYT|rcsb pdb:1MWP|rcsb pdb:1OWT|rcsb pdb:1QCM|rcsb pdb:1QWP|rcsb pdb:1QXC|rcsb pdb:1QYT|rcsb pdb:1TAW|rcsb pdb:1TKN|rcsb pdb:1UO7|rcsb pdb:1UO8|rcsb pdb:1UOA|rcsb pdb:1UOI|rcsb pdb:1X11|rcsb pdb:1Z0Q|rcsb pdb:1ZE7|rcsb pdb:1ZE9|rcsb pdb:1ZJD|rcsb pdb:2BEG|rcsb pdb:2BOM|rcsb pdb:2BP4|rcsb pdb:2FJZ|rcsb pdb:2FK1|rcsb pdb:2FK2|rcsb pdb:2FK3|rcsb pdb:2FKL|rcsb pdb:2FMA|rcsb pdb:2G47|rcsb pdb:2IPU|rcsb pdb:2LFM|rcsb pdb:2LLM|rcsb pdb:2LMN|rcsb pdb:2LMO|rcsb pdb:2LMP|rcsb pdb:2LMQ|rcsb pdb:2LNQ|rcsb pdb:2LOH|rcsb pdb:2LP1|rcsb pdb:2LZ3|rcsb pdb:2Y2A|rcsb pdb:2Y3J|rcsb pdb:2Y3K|rcsb pdb:2Y3L|rcsb pdb:3AYU|rcsb pdb:3BAE|rcsb pdb:3BKJ|rcsb pdb:3DXC|rcsb pdb:3DXD|rcsb pdb:3DXE|rcsb pdb:3GCI|rcsb pdb:3IFL|rcsb pdb:3IFN|rcsb pdb:3IFO|rcsb pdb:3IFP|rcsb pdb:3JQ5|rcsb pdb:3JQL|rcsb pdb:3JTI|rcsb pdb:3KTM|rcsb pdb:3L33|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904591"(positive regulation of protein import)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:1905893"(positive regulation of cellular response to thapsigargin)|go:"GO:1905896"(positive regulation of cellular response to tunicamycin)|go:"GO:1905898"(positive regulation of response to endoplasmic reticulum stress)|go:"GO:1905906"(regulation of amyloid fibril formation)|go:"GO:1905908"(positive regulation of amyloid fibril formation)|go:"GO:1905945"(regulation of response to calcium ion)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990535"(neuron projection maintenance)|go:"GO:1990761"(growth cone lamellipodium)|go:"GO:1990777"(lipoprotein particle)|go:"GO:1990812"(growth cone filopodium)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR002223(Proteinase inhibitor I2, Kunitz metazoa)|interpro:IPR008154(Amyloidogenic glycoprotein, extracellular)|interpro:IPR008155(Amyloidogenic glycoprotein, core)|interpro:IPR011178(Amyloidogenic glycoprotein, copper-binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013803(Amyloidogenic glycoprotein, amyloid-beta peptide)|interpro:IPR015849(Amyloidogenic glycoprotein, heparin-binding)|interpro:IPR019543|interpro:IPR019744|interpro:IPR019745|interpro:IPR020901|interpro:IPR024329|interpro:IPR028866|interpro:IPR036176|interpro:IPR036454|interpro:IPR036669|rcsb pdb:5HOY|rcsb pdb:5KK3|rcsb pdb:5LFY|rcsb pdb:5LV0|rcsb pdb:5MY4|rcsb pdb:5MYO|rcsb pdb:5MYX|rcsb pdb:5ONP|rcsb pdb:5ONQ|rcsb pdb:5OQV|rcsb pdb:5TXD|rcsb pdb:5VOS|rcsb pdb:5VZY|rcsb pdb:5W3P|rcsb pdb:6CO3|rcsb pdb:6GFI|rcsb pdb:6ITU|rcsb pdb:6IYC|rcsb pdb:6NB9|rcsb pdb:6O4J|rcsb pdb:6OC9|rcsb pdb:6OIZ|rcsb pdb:6RHY|rcsb pdb:6SHS|rcsb pdb:6SZF|rcsb pdb:6TI5|rcsb pdb:6TI6|rcsb pdb:6TI7|rcsb pdb:6W0O|rcsb pdb:6WXM|rcsb pdb:6YHF|rcsb pdb:6YHI|rcsb pdb:6YHO|rcsb pdb:6YHP|rcsb pdb:6YHX|rcsb pdb:7B3J|rcsb pdb:7B3K|rcsb pdb:7JXN|rcsb pdb:7JXO|rcsb pdb:7O1Q|reactome:R-HSA-114608|reactome:R-HSA-3000178|reactome:R-HSA-381426|reactome:R-HSA-416476|reactome:R-HSA-418594|reactome:R-HSA-432720|reactome:R-HSA-444473|reactome:R-HSA-445989|reactome:R-HSA-844456|reactome:R-HSA-879415|reactome:R-HSA-8862803|reactome:R-HSA-8957275|reactome:R-HSA-933542|reactome:R-HSA-9609523|reactome:R-HSA-9660826|reactome:R-HSA-977225|rcsb pdb:5AMB|rcsb pdb:5BUO|rcsb pdb:5C67|rcsb pdb:5CSZ|rcsb pdb:5HOW|rcsb pdb:5HOX|rcsb pdb:3L81|rcsb pdb:3MOQ|rcsb pdb:3MXC|rcsb pdb:3MXY|rcsb pdb:3NYJ|rcsb pdb:3NYL|rcsb pdb:3OVJ|rcsb pdb:3OW9|rcsb pdb:3PZZ|rcsb pdb:3Q2X|rcsb pdb:3SV1|rcsb pdb:3U0T|rcsb pdb:3UMH|rcsb pdb:3UMI|rcsb pdb:3UMK|rcsb pdb:4HIX|rcsb pdb:4JFN|rcsb pdb:4M1C|rcsb pdb:4MDR|rcsb pdb:4MVI|rcsb pdb:4MVK|rcsb pdb:4MVL|rcsb pdb:4NGE|rcsb pdb:4OJF|rcsb pdb:4ONF|rcsb pdb:4ONG|rcsb pdb:4PQD|rcsb pdb:4PWQ|rcsb pdb:4XXD|rcsb pdb:5AEF|rcsb pdb:5AM8|refseq:NP_000475.1|refseq:NP_001129601.1|refseq:NP_001129602.1|refseq:NP_001191230.1|refseq:NP_001191231.1|refseq:NP_001191232.1|refseq:NP_958816.1|refseq:NP_958817.1|ensembl:ENSP00000284981|ensembl:ENST00000348990|ensembl:ENSP00000345463|ensembl:ENST00000354192|ensembl:ENSP00000346129|ensembl:ENST00000357903|ensembl:ENSP00000350578|ensembl:ENST00000358918|ensembl:ENSP00000351796|ensembl:ENST00000440126|ensembl:ENSP00000387483|refseq:NP_001129488.1|refseq:NP_001129603.1|dip:DIP-574N	refseq:NP_000258.1|refseq:NP_001035957.1|refseq:NP_001121619.1|ensembl:ENSG00000196712(gene)|ensembl:ENST00000358273(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001656"(metanephros development)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001889"(liver development)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007154"(cell communication)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007420"(brain development)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0008542"(visual learning)|go:"GO:0014044"(Schwann cell development)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0021510"(spinal cord development)|go:"GO:0021897"(forebrain astrocyte development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0042060"(wound healing)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043473"(pigmentation)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043535"(regulation of blood vessel endothelial cell migration)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045685"(regulation of glial cell differentiation)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0050890"(cognition)|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR023152|interpro:IPR036865|interpro:IPR039360|mint:P21359|rcsb pdb:1NF1|rcsb pdb:2E2X|rcsb pdb:3P7Z|rcsb pdb:3PEG|rcsb pdb:3PG7|rcsb pdb:6OB2|rcsb pdb:6OB3|rcsb pdb:6V65|rcsb pdb:6V6F|reactome:R-HSA-5658442|reactome:R-HSA-6802953|rcsb pdb:2D4Q	-	-	-	dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/09/01	2014/10/16	rogid:HatR8w8+mNjtjr7s5+bAwaStpmk9606	rogid:9/AAe+70biVtuhfi0XOaUUkg4D09606	intact-crc:C31349E453DACD57|rigid:gVvuC54Yl/+xT9g/wsHjUQq8XT0	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)