#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P18545	uniprotkb:P62994	intact:EBI-2622029|uniprotkb:Q3KP63|uniprotkb:Q7Z3U8|ensembl:ENSP00000328412|ensembl:ENSP00000458167|ensembl:ENSP00000461464	intact:EBI-401775|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q5BKA7|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSRNOP00000005347	psi-mi:cnrg_human(display_long)|uniprotkb:PDEG(gene name synonym)|uniprotkb:PDE6G(gene name)|psi-mi:PDE6G(display_short)	psi-mi:grb2_rat(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Ash(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Houdart et al. (2005)	pubmed:16357825|mint:MINT-7148415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7942874|mint:MINT-7157301	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006722005.1|refseq:NP_002593.1|refseq:XP_016880224.1|refseq:XP_016880225.1|ensembl:ENSG00000185527(gene)|ensembl:ENST00000331056(transcript)|ensembl:ENST00000571004(transcript)|ensembl:ENST00000571224(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007601"(visual perception)|go:"GO:0030507"(spectrin binding)|go:"GO:0030553"(cGMP binding)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0047555"(3',5'-cyclic-GMP phosphodiesterase activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0097381"(photoreceptor disc membrane)|interpro:IPR006952(Retinal cGMP phosphodiesterase, gamma subunit)|interpro:IPR037030|mint:P18545|rcsb pdb:3JWR|reactome:R-HSA-2485179|reactome:R-HSA-2514859|reactome:R-HSA-4086398|mint:MINT-7157308(identity)	rgd:619758|refseq:NP_110473.2|ensembl:ENSRNOG00000003990(gene)|ensembl:ENSRNOT00000005347(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62994|reactome:R-RNO-109704|reactome:R-RNO-112412|reactome:R-RNO-1250347|reactome:R-RNO-1257604|reactome:R-RNO-1295596|reactome:R-RNO-1433557|reactome:R-RNO-1433559|reactome:R-RNO-167044|reactome:R-RNO-179812|reactome:R-RNO-180292|reactome:R-RNO-180336|reactome:R-RNO-182971|reactome:R-RNO-186763|reactome:R-RNO-1963640|reactome:R-RNO-1963642|reactome:R-RNO-2029482|reactome:R-RNO-210993|reactome:R-RNO-2179392|reactome:R-RNO-2424491|reactome:R-RNO-2428933|reactome:R-RNO-2730905|reactome:R-RNO-2871796|reactome:R-RNO-2871809|reactome:R-RNO-354194|reactome:R-RNO-375165|reactome:R-RNO-388841|reactome:R-RNO-389359|reactome:R-RNO-391160|reactome:R-RNO-5654688|reactome:R-RNO-5654689|reactome:R-RNO-5654693|reactome:R-RNO-5654695|reactome:R-RNO-5654699|reactome:R-RNO-5654700|reactome:R-RNO-5654704|reactome:R-RNO-5654706|reactome:R-RNO-5654710|reactome:R-RNO-5654712|reactome:R-RNO-5654719|reactome:R-RNO-5654720|reactome:R-RNO-5654726|reactome:R-RNO-5654727|reactome:R-RNO-5654732|reactome:R-RNO-5654733|reactome:R-RNO-5663213|reactome:R-RNO-5673001|reactome:R-RNO-6807004|reactome:R-RNO-6811558|reactome:R-RNO-74749|reactome:R-RNO-74751|reactome:R-RNO-8851805|reactome:R-RNO-8851907|reactome:R-RNO-8853659|reactome:R-RNO-8856828|reactome:R-RNO-8865999|reactome:R-RNO-8875555|reactome:R-RNO-8875656|reactome:R-RNO-8983432|reactome:R-RNO-9027284|reactome:R-RNO-9028731|reactome:R-RNO-912526|reactome:R-RNO-912631|reactome:R-RNO-9607240|reactome:R-RNO-9674555|reactome:R-RNO-983695|reactome:R-RNO-8856825|mint:MINT-7157303(identity)	-	-	-	figure legend:f2a f2b|comment:homomint|comment:mint|curation depth:mimix curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2009/06/11	2014/10/16	rogid:gsjKwWpx+sGGCwYus6BYMNKbnv89606	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA410116	intact-crc:D9E88B23B86F7A1D|rigid:kCMsgltPvJdhhK8fqelQG+wgBzk	false	binding-associated region:1-65(MINT-7157313)|mutation decreasing interaction:23-23(MINT-7157309)|mutation decreasing interaction:20-20(MINT-7157311)	binding-associated region:1-204(MINT-7157304)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9QY17	uniprotkb:P18545	intact:EBI-491201|uniprotkb:Q9QY18|uniprotkb:Q9QY19|uniprotkb:Q9QY20|ensembl:ENSRNOP00000060074	intact:EBI-2622029|uniprotkb:Q3KP63|uniprotkb:Q7Z3U8|ensembl:ENSP00000328412|ensembl:ENSP00000458167|ensembl:ENSP00000461464	psi-mi:pacn2_rat(display_long)|uniprotkb:Synaptic dynamin-associated protein II(gene name synonym)|uniprotkb:Syndapin-II(gene name synonym)|uniprotkb:Pacsin2(gene name)|psi-mi:Pacsin2(display_short)|uniprotkb:Syndapin-2(gene name synonym)	psi-mi:cnrg_human(display_long)|uniprotkb:PDEG(gene name synonym)|uniprotkb:PDE6G(gene name)|psi-mi:PDE6G(display_short)	psi-mi:"MI:0018"(two hybrid)	Houdart et al. (2005)	pubmed:16357825|mint:MINT-7148415	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7942845|mint:MINT-7157274	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:69411|refseq:NP_570096.2|refseq:XP_017450116.1|refseq:XP_006242112.1|refseq:XP_006242113.1|refseq:XP_006242114.1|refseq:XP_006242115.1|refseq:XP_006242117.1|refseq:XP_006242120.1|refseq:XP_006242122.1|ensembl:ENSRNOG00000009756(gene)|ensembl:ENSRNOT00000067913(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008289"(lipid binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0032587"(ruffle membrane)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0048858"(cell projection morphogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0070836"(caveola assembly)|go:"GO:0097320"(plasma membrane tubulation)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|interpro:IPR027267|interpro:IPR028521|interpro:IPR031160|interpro:IPR035743|interpro:IPR036028|interpro:IPR037453|mint:Q9QY17|reactome:R-RNO-8856828|go:"GO:0072584"(caveolin-mediated endocytosis)|mint:MINT-7157276(identity)	refseq:XP_006722005.1|refseq:NP_002593.1|refseq:XP_016880224.1|refseq:XP_016880225.1|ensembl:ENSG00000185527(gene)|ensembl:ENST00000331056(transcript)|ensembl:ENST00000571004(transcript)|ensembl:ENST00000571224(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007601"(visual perception)|go:"GO:0030507"(spectrin binding)|go:"GO:0030553"(cGMP binding)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0047555"(3',5'-cyclic-GMP phosphodiesterase activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0097381"(photoreceptor disc membrane)|interpro:IPR006952(Retinal cGMP phosphodiesterase, gamma subunit)|interpro:IPR037030|mint:P18545|rcsb pdb:3JWR|reactome:R-HSA-2485179|reactome:R-HSA-2514859|reactome:R-HSA-4086398|mint:MINT-7157277(identity)	-	-	-	figure legend:f2a f2b|comment:homomint|comment:mint|curation depth:mimix curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2009/06/11	2014/10/16	rogid:sXAD5lVFEutV+uJ4vm0xYA6VF2E10116	rogid:gsjKwWpx+sGGCwYus6BYMNKbnv89606	intact-crc:00DD8C825376A3FF|rigid:wJQbZfEdhKbkxfFXqLrrfwB79q4	false	binding-associated region:?-?(MINT-7157290)	mutation decreasing interaction:23-23(MINT-7157285)|mutation decreasing interaction:20-20(MINT-7157282)|binding-associated region:1-65(MINT-7157280)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P18545	uniprotkb:Q63787	intact:EBI-2622029|uniprotkb:Q3KP63|uniprotkb:Q7Z3U8|ensembl:ENSP00000328412|ensembl:ENSP00000458167|ensembl:ENSP00000461464	intact:EBI-518443|uniprotkb:O55085|uniprotkb:P70544|uniprotkb:Q63790	psi-mi:cnrg_human(display_long)|uniprotkb:PDEG(gene name synonym)|uniprotkb:PDE6G(gene name)|psi-mi:PDE6G(display_short)	psi-mi:p85a_rat(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:Pik3r1(gene name)|psi-mi:Pik3r1(display_short)	psi-mi:"MI:0018"(two hybrid)	Houdart et al. (2005)	pubmed:16357825|mint:MINT-7148415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7942918|mint:MINT-7157399	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006722005.1|refseq:NP_002593.1|refseq:XP_016880224.1|refseq:XP_016880225.1|ensembl:ENSG00000185527(gene)|ensembl:ENST00000331056(transcript)|ensembl:ENST00000571004(transcript)|ensembl:ENST00000571224(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007601"(visual perception)|go:"GO:0030507"(spectrin binding)|go:"GO:0030553"(cGMP binding)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0047555"(3',5'-cyclic-GMP phosphodiesterase activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0097381"(photoreceptor disc membrane)|interpro:IPR006952(Retinal cGMP phosphodiesterase, gamma subunit)|interpro:IPR037030|mint:P18545|rcsb pdb:3JWR|reactome:R-HSA-2485179|reactome:R-HSA-2514859|reactome:R-HSA-4086398|mint:MINT-7157401(identity)	rgd:3329|refseq:NP_037137.1|mint:Q63787|dip:DIP-33696N|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009750"(response to fructose)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0033574"(response to testosterone)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043200"(response to amino acid)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051591"(response to cAMP)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0070542"(response to fatty acid)|go:"GO:0070848"(response to growth factor)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|rcsb pdb:1FU5|rcsb pdb:1FU6|reactome:R-RNO-109704|reactome:R-RNO-112399|reactome:R-RNO-114604|reactome:R-RNO-1250342|reactome:R-RNO-1257604|reactome:R-RNO-1266695|reactome:R-RNO-1433557|reactome:R-RNO-1660499|reactome:R-RNO-180292|reactome:R-RNO-186763|reactome:R-RNO-1963642|reactome:R-RNO-198203|reactome:R-RNO-202424|reactome:R-RNO-2029485|reactome:R-RNO-210993|reactome:R-RNO-2424491|reactome:R-RNO-2730905|reactome:R-RNO-388841|reactome:R-RNO-389357|reactome:R-RNO-416476|reactome:R-RNO-430116|reactome:R-RNO-4420097|reactome:R-RNO-512988|reactome:R-RNO-5654689|reactome:R-RNO-5654695|reactome:R-RNO-5654710|reactome:R-RNO-5654720|reactome:R-RNO-5673001|reactome:R-RNO-6811558|reactome:R-RNO-8851907|reactome:R-RNO-8853659|reactome:R-RNO-8980692|reactome:R-RNO-9009391|reactome:R-RNO-9013026|reactome:R-RNO-9013106|reactome:R-RNO-9013148|reactome:R-RNO-9013149|reactome:R-RNO-9013404|reactome:R-RNO-9013405|reactome:R-RNO-9013408|reactome:R-RNO-9013409|reactome:R-RNO-9013420|reactome:R-RNO-9013423|reactome:R-RNO-9013424|reactome:R-RNO-9027276|reactome:R-RNO-9035034|reactome:R-RNO-912526|reactome:R-RNO-912631|reactome:R-RNO-9607240|reactome:R-RNO-9696264|reactome:R-RNO-9696270|reactome:R-RNO-9696273|reactome:R-RNO-983695|mint:MINT-7157409(identity)	-	-	-	comment:homomint|comment:mint|figure legend:f2a|curation depth:mimix curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2009/06/11	2014/10/16	rogid:gsjKwWpx+sGGCwYus6BYMNKbnv89606	rogid:jr9Hr1Rmtwi0SRC6OSkceJ+hSFU10116	intact-crc:23EB025236120E05|rigid:IfFbX4453mXev0qWe357gtoxlJM	false	binding-associated region:1-65(MINT-7157402)	binding-associated region:1-234(MINT-7157410)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9WUD9	uniprotkb:P18545	intact:EBI-7784541|ensembl:ENSRNOP00000012739|intact:MINT-1488989|intact:EBI-8633267|intact:MINT-264632|uniprotkb:G3V776|uniprotkb:Q45QJ2|uniprotkb:Q9JJ10	intact:EBI-2622029|uniprotkb:Q3KP63|uniprotkb:Q7Z3U8|ensembl:ENSP00000328412|ensembl:ENSP00000458167|ensembl:ENSP00000461464	psi-mi:src_rat(display_long)|uniprotkb:Src(gene name)|psi-mi:Src(display_short)|uniprotkb:pp60c-src(gene name synonym)|uniprotkb:Proto-oncogene c-Src(gene name synonym)	psi-mi:cnrg_human(display_long)|uniprotkb:PDEG(gene name synonym)|uniprotkb:PDE6G(gene name)|psi-mi:PDE6G(display_short)	psi-mi:"MI:0018"(two hybrid)	Houdart et al. (2005)	pubmed:16357825|mint:MINT-7148415	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7942964|mint:MINT-7157434	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008760609.1|refseq:XP_008760610.1|ensembl:ENSRNOG00000009495(gene)|ensembl:ENSRNOT00000012739(transcript)|go:"GO:0001545"(primary ovarian follicle growth)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002102"(podosome)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0005884"(actin filament)|go:"GO:0009615"(response to virus)|go:"GO:0010447"(response to acidic pH)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010641"(positive regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0020037"(heme binding)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|refseq:XP_017447554.1|refseq:XP_017447555.1|refseq:XP_017447556.1|refseq:XP_017447557.1|refseq:XP_017447558.1|refseq:XP_017447559.1|refseq:XP_017447560.1|refseq:XP_017447561.1|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033146"(regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035306"(positive regulation of dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036035"(osteoclast development)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042476"(odontogenesis)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045056"(transcytosis)|go:"GO:0045087"(innate immune response)|go:"GO:0045453"(bone resorption)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048477"(oogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051385"(response to mineralocorticoid)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060065"(uterus development)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070542"(response to fatty acid)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071253"(connexin binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071393"(cellular response to progesterone stimulus)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0086098"(angiotensin-activated signaling pathway involved in heart process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000394"(positive regulation of lamellipodium morphogenesis)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|go:"GO:2001286"(regulation of caveolin-mediated endocytosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036028|interpro:IPR036860|mint:Q9WUD9|reactome:R-RNO-1227986|reactome:R-RNO-1251985|reactome:R-RNO-1253288|reactome:R-RNO-1257604|reactome:R-RNO-1295596|reactome:R-RNO-1433557|reactome:R-RNO-1433559|reactome:R-RNO-177929|reactome:R-RNO-180292|reactome:R-RNO-186763|reactome:R-RNO-191650|reactome:R-RNO-2029481|reactome:R-RNO-210990|reactome:R-RNO-354192|reactome:R-RNO-354194|reactome:R-RNO-372708|reactome:R-RNO-389356|reactome:R-RNO-389513|reactome:R-RNO-3928662|reactome:R-RNO-3928663|reactome:R-RNO-3928664|reactome:R-RNO-3928665|reactome:R-RNO-418592|reactome:R-RNO-418594|reactome:R-RNO-418885|reactome:R-RNO-430116|reactome:R-RNO-437239|reactome:R-RNO-4420097|reactome:R-RNO-456926|reactome:R-RNO-5218921|reactome:R-RNO-5607764|reactome:R-RNO-5663220|reactome:R-RNO-5673000|reactome:R-RNO-5674135|reactome:R-RNO-6811558|reactome:R-RNO-69231|reactome:R-RNO-8853659|reactome:R-RNO-8874081|reactome:R-RNO-8934903|reactome:R-RNO-8941858|reactome:R-RNO-9603381|reactome:R-RNO-9009391|refseq:NP_114183.1|rgd:620795|dip:DIP-42731N	refseq:XP_006722005.1|refseq:NP_002593.1|refseq:XP_016880224.1|refseq:XP_016880225.1|ensembl:ENSG00000185527(gene)|ensembl:ENST00000331056(transcript)|ensembl:ENST00000571004(transcript)|ensembl:ENST00000571224(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007601"(visual perception)|go:"GO:0030507"(spectrin binding)|go:"GO:0030553"(cGMP binding)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0047555"(3',5'-cyclic-GMP phosphodiesterase activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0097381"(photoreceptor disc membrane)|interpro:IPR006952(Retinal cGMP phosphodiesterase, gamma subunit)|interpro:IPR037030|mint:P18545|rcsb pdb:3JWR|reactome:R-HSA-2485179|reactome:R-HSA-2514859|reactome:R-HSA-4086398|mint:MINT-7157436(identity)	-	comment:mint|comment:homomint	-	figure legend:f2a f2b|comment:homomint|comment:mint|curation depth:mimix curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2009/06/11	2014/10/16	rogid:nxU40GY4yiVLT+BMi6GuF5YETGA10116	rogid:gsjKwWpx+sGGCwYus6BYMNKbnv89606	intact-crc:F86AD9A2424BEE8C|rigid:1XZdcERofWGkLAZTihS1Bmqi43M	false	binding-associated region:71-234	mutation disrupting interaction:20-20(MINT-7157439)|mutation disrupting interaction:23-23(MINT-7157437)|binding-associated region:1-65(MINT-7157441)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8R511	uniprotkb:P18545	intact:EBI-1111424|uniprotkb:Q75UE2|uniprotkb:Q75UE3|uniprotkb:Q75UE4|uniprotkb:Q75UE5|uniprotkb:Q75UE6	intact:EBI-2622029|uniprotkb:Q3KP63|uniprotkb:Q7Z3U8|ensembl:ENSP00000328412|ensembl:ENSP00000458167|ensembl:ENSP00000461464	psi-mi:fnbp1_rat(display_long)|uniprotkb:Fnbp1(gene name)|psi-mi:Fnbp1(display_short)|uniprotkb:Formin-binding protein 17(gene name synonym)|uniprotkb:Rapostlin(gene name synonym)|uniprotkb:Fbp17(gene name synonym)	psi-mi:cnrg_human(display_long)|uniprotkb:PDEG(gene name synonym)|uniprotkb:PDE6G(gene name)|psi-mi:PDE6G(display_short)	psi-mi:"MI:0018"(two hybrid)	Houdart et al. (2005)	pubmed:16357825|mint:MINT-7148415	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7942937|mint:MINT-7157416	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR027267|interpro:IPR028532|rgd:621350|refseq:NP_620269.1|interpro:IPR031160|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|go:"GO:0005764"(lysosome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0008289"(lipid binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042802"(identical protein binding)|reactome:R-RNO-8856828|reactome:R-RNO-9013148|reactome:R-RNO-9013406|reactome:R-RNO-9696270|interpro:IPR035492|interpro:IPR037449|mint:Q8R511|interpro:IPR036028|interpro:IPR011072(HR1 rho-binding repeat)|mint:MINT-7157426(identity)	refseq:XP_006722005.1|refseq:NP_002593.1|refseq:XP_016880224.1|refseq:XP_016880225.1|ensembl:ENSG00000185527(gene)|ensembl:ENST00000331056(transcript)|ensembl:ENST00000571004(transcript)|ensembl:ENST00000571224(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007601"(visual perception)|go:"GO:0030507"(spectrin binding)|go:"GO:0030553"(cGMP binding)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0047555"(3',5'-cyclic-GMP phosphodiesterase activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0097381"(photoreceptor disc membrane)|interpro:IPR006952(Retinal cGMP phosphodiesterase, gamma subunit)|interpro:IPR037030|mint:P18545|rcsb pdb:3JWR|reactome:R-HSA-2485179|reactome:R-HSA-2514859|reactome:R-HSA-4086398|mint:MINT-7157418(identity)	-	-	-	figure legend:f2a f2b|comment:homomint|comment:mint|curation depth:mimix curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2009/06/11	2014/10/16	rogid:Ryvj22B76jaT6vpwvnmlbm5k/Yk10116	rogid:gsjKwWpx+sGGCwYus6BYMNKbnv89606	intact-crc:1C8F0EDE115DC6B1|rigid:2V1wAGdqhIkvOlpJobB7VTfG+n4	false	binding-associated region:3-79(MINT-7157427)	binding-associated region:1-65(MINT-7157423)|mutation disrupting interaction:23-23(MINT-7157419)|mutation disrupting interaction:20-20(MINT-7157421)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O08839	uniprotkb:P18545	intact:EBI-80095	intact:EBI-2622029|uniprotkb:Q3KP63|uniprotkb:Q7Z3U8|ensembl:ENSP00000328412|ensembl:ENSP00000458167|ensembl:ENSP00000461464	psi-mi:bin1_rat(display_long)|uniprotkb:Bin1(gene name)|psi-mi:Bin1(display_short)|uniprotkb:Amph2(gene name synonym)|uniprotkb:Amphl(gene name synonym)|uniprotkb:Bridging integrator 1(gene name synonym)|uniprotkb:Amphiphysin-like protein(gene name synonym)|uniprotkb:Amphiphysin II(gene name synonym)	psi-mi:cnrg_human(display_long)|uniprotkb:PDEG(gene name synonym)|uniprotkb:PDE6G(gene name)|psi-mi:PDE6G(display_short)	psi-mi:"MI:0018"(two hybrid)	Houdart et al. (2005)	pubmed:16357825|mint:MINT-7148415	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7942991|mint:MINT-7157451	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005768"(endosome)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006997"(nucleus organization)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0016020"(membrane)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031674"(I band)|go:"GO:0031982"(vesicle)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033292"(T-tubule organization)|go:"GO:0042692"(muscle cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043194"(axon initial segment)|go:"GO:0043196"(varicosity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048156"(tau protein binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051647"(nucleus localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060987"(lipid tube)|go:"GO:0060988"(lipid tube assembly)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1904878"(negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|interpro:IPR001452(Src homology-3)|interpro:IPR003005(Amphiphysin)|interpro:IPR003023(Amphiphysin, isoform 2)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035471|interpro:IPR036028|rcsb pdb:1BB9|reactome:R-RNO-8856828|go:"GO:1903946"(negative regulation of ventricular cardiac muscle cell action potential)|rgd:621786|refseq:NP_446411.1|mint:O08839|dip:DIP-30979N|mint:MINT-7157461(identity)	refseq:XP_006722005.1|refseq:NP_002593.1|refseq:XP_016880224.1|refseq:XP_016880225.1|ensembl:ENSG00000185527(gene)|ensembl:ENST00000331056(transcript)|ensembl:ENST00000571004(transcript)|ensembl:ENST00000571224(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007601"(visual perception)|go:"GO:0030507"(spectrin binding)|go:"GO:0030553"(cGMP binding)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0047555"(3',5'-cyclic-GMP phosphodiesterase activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0097381"(photoreceptor disc membrane)|interpro:IPR006952(Retinal cGMP phosphodiesterase, gamma subunit)|interpro:IPR037030|mint:P18545|rcsb pdb:3JWR|reactome:R-HSA-2485179|reactome:R-HSA-2514859|reactome:R-HSA-4086398|mint:MINT-7157453(identity)	-	-	-	figure legend:f2a|comment:homomint|comment:mint|curation depth:mimix curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2009/06/11	2014/10/16	rogid:xqcXQWo+FXHjCGGI0Q9agaz9LMk10116	rogid:gsjKwWpx+sGGCwYus6BYMNKbnv89606	intact-crc:5A903CFD907D2314|rigid:tqieoeALLyR9K9yoBUfSUkt0LCQ	false	binding-associated region:?-?(MINT-7157462)	binding-associated region:1-65(MINT-7157454)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9QY17	uniprotkb:P18545	intact:EBI-491201|uniprotkb:Q9QY18|uniprotkb:Q9QY19|uniprotkb:Q9QY20|ensembl:ENSRNOP00000060074	intact:EBI-2622029|uniprotkb:Q3KP63|uniprotkb:Q7Z3U8|ensembl:ENSP00000328412|ensembl:ENSP00000458167|ensembl:ENSP00000461464	psi-mi:pacn2_rat(display_long)|uniprotkb:Synaptic dynamin-associated protein II(gene name synonym)|uniprotkb:Syndapin-II(gene name synonym)|uniprotkb:Pacsin2(gene name)|psi-mi:Pacsin2(display_short)|uniprotkb:Syndapin-2(gene name synonym)	psi-mi:cnrg_human(display_long)|uniprotkb:PDEG(gene name synonym)|uniprotkb:PDE6G(gene name)|psi-mi:PDE6G(display_short)	psi-mi:"MI:0096"(pull down)	Houdart et al. (2005)	pubmed:16357825|mint:MINT-7148415	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7943021|mint:MINT-7157494	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:69411|refseq:NP_570096.2|refseq:XP_017450116.1|refseq:XP_006242112.1|refseq:XP_006242113.1|refseq:XP_006242114.1|refseq:XP_006242115.1|refseq:XP_006242117.1|refseq:XP_006242120.1|refseq:XP_006242122.1|ensembl:ENSRNOG00000009756(gene)|ensembl:ENSRNOT00000067913(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008289"(lipid binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0032587"(ruffle membrane)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0048858"(cell projection morphogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0070836"(caveola assembly)|go:"GO:0097320"(plasma membrane tubulation)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|interpro:IPR027267|interpro:IPR028521|interpro:IPR031160|interpro:IPR035743|interpro:IPR036028|interpro:IPR037453|mint:Q9QY17|reactome:R-RNO-8856828|go:"GO:0072584"(caveolin-mediated endocytosis)|mint:MINT-7157496(identity)	refseq:XP_006722005.1|refseq:NP_002593.1|refseq:XP_016880224.1|refseq:XP_016880225.1|ensembl:ENSG00000185527(gene)|ensembl:ENST00000331056(transcript)|ensembl:ENST00000571004(transcript)|ensembl:ENST00000571224(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007601"(visual perception)|go:"GO:0030507"(spectrin binding)|go:"GO:0030553"(cGMP binding)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0047555"(3',5'-cyclic-GMP phosphodiesterase activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0097381"(photoreceptor disc membrane)|interpro:IPR006952(Retinal cGMP phosphodiesterase, gamma subunit)|interpro:IPR037030|mint:P18545|rcsb pdb:3JWR|reactome:R-HSA-2485179|reactome:R-HSA-2514859|reactome:R-HSA-4086398|mint:MINT-7157501(identity)	-	-	-	comment:homomint|comment:mint|figure legend:f2c|curation depth:mimix curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/11	2014/10/16	rogid:sXAD5lVFEutV+uJ4vm0xYA6VF2E10116	rogid:gsjKwWpx+sGGCwYus6BYMNKbnv89606	intact-crc:C5C7F49714E97773|rigid:wJQbZfEdhKbkxfFXqLrrfwB79q4	false	binding-associated region:?-?(MINT-7157497)	glutathione s tranferase tag:?-?(MINT-7157557)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P18545	uniprotkb:Q9QY17	intact:EBI-2622029|uniprotkb:Q3KP63|uniprotkb:Q7Z3U8|ensembl:ENSP00000328412|ensembl:ENSP00000458167|ensembl:ENSP00000461464	intact:EBI-491201|uniprotkb:Q9QY18|uniprotkb:Q9QY19|uniprotkb:Q9QY20|ensembl:ENSRNOP00000060074	psi-mi:cnrg_human(display_long)|uniprotkb:PDEG(gene name synonym)|uniprotkb:PDE6G(gene name)|psi-mi:PDE6G(display_short)	psi-mi:pacn2_rat(display_long)|uniprotkb:Synaptic dynamin-associated protein II(gene name synonym)|uniprotkb:Syndapin-II(gene name synonym)|uniprotkb:Pacsin2(gene name)|psi-mi:Pacsin2(display_short)|uniprotkb:Syndapin-2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Houdart et al. (2005)	pubmed:16357825|mint:MINT-7148415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7943042|mint:MINT-7157570	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006722005.1|refseq:NP_002593.1|refseq:XP_016880224.1|refseq:XP_016880225.1|ensembl:ENSG00000185527(gene)|ensembl:ENST00000331056(transcript)|ensembl:ENST00000571004(transcript)|ensembl:ENST00000571224(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007601"(visual perception)|go:"GO:0030507"(spectrin binding)|go:"GO:0030553"(cGMP binding)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0047555"(3',5'-cyclic-GMP phosphodiesterase activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0097381"(photoreceptor disc membrane)|interpro:IPR006952(Retinal cGMP phosphodiesterase, gamma subunit)|interpro:IPR037030|mint:P18545|rcsb pdb:3JWR|reactome:R-HSA-2485179|reactome:R-HSA-2514859|reactome:R-HSA-4086398|mint:MINT-7157577(identity)	rgd:69411|refseq:NP_570096.2|refseq:XP_017450116.1|refseq:XP_006242112.1|refseq:XP_006242113.1|refseq:XP_006242114.1|refseq:XP_006242115.1|refseq:XP_006242117.1|refseq:XP_006242120.1|refseq:XP_006242122.1|ensembl:ENSRNOG00000009756(gene)|ensembl:ENSRNOT00000067913(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008289"(lipid binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0032587"(ruffle membrane)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0048858"(cell projection morphogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0070836"(caveola assembly)|go:"GO:0097320"(plasma membrane tubulation)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|interpro:IPR027267|interpro:IPR028521|interpro:IPR031160|interpro:IPR035743|interpro:IPR036028|interpro:IPR037453|mint:Q9QY17|reactome:R-RNO-8856828|go:"GO:0072584"(caveolin-mediated endocytosis)|mint:MINT-7157572(identity)	-	-	-	figure legend:f4a|comment:homomint|comment:mint|curation depth:mimix curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/11	2014/10/16	rogid:gsjKwWpx+sGGCwYus6BYMNKbnv89606	rogid:sXAD5lVFEutV+uJ4vm0xYA6VF2E10116	intact-crc:B9543619F511F946|rigid:wJQbZfEdhKbkxfFXqLrrfwB79q4	false	glutathione s tranferase tag:?-?(MINT-7157578)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q63787	uniprotkb:P18545	intact:EBI-518443|uniprotkb:O55085|uniprotkb:P70544|uniprotkb:Q63790	intact:EBI-2622029|uniprotkb:Q3KP63|uniprotkb:Q7Z3U8|ensembl:ENSP00000328412|ensembl:ENSP00000458167|ensembl:ENSP00000461464	psi-mi:p85a_rat(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:Pik3r1(gene name)|psi-mi:Pik3r1(display_short)	psi-mi:cnrg_human(display_long)|uniprotkb:PDEG(gene name synonym)|uniprotkb:PDE6G(gene name)|psi-mi:PDE6G(display_short)	psi-mi:"MI:0096"(pull down)	Houdart et al. (2005)	pubmed:16357825|mint:MINT-7148415	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7943093|mint:MINT-7157742	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:3329|refseq:NP_037137.1|mint:Q63787|dip:DIP-33696N|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009750"(response to fructose)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0033574"(response to testosterone)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043200"(response to amino acid)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051591"(response to cAMP)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0070542"(response to fatty acid)|go:"GO:0070848"(response to growth factor)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|rcsb pdb:1FU5|rcsb pdb:1FU6|reactome:R-RNO-109704|reactome:R-RNO-112399|reactome:R-RNO-114604|reactome:R-RNO-1250342|reactome:R-RNO-1257604|reactome:R-RNO-1266695|reactome:R-RNO-1433557|reactome:R-RNO-1660499|reactome:R-RNO-180292|reactome:R-RNO-186763|reactome:R-RNO-1963642|reactome:R-RNO-198203|reactome:R-RNO-202424|reactome:R-RNO-2029485|reactome:R-RNO-210993|reactome:R-RNO-2424491|reactome:R-RNO-2730905|reactome:R-RNO-388841|reactome:R-RNO-389357|reactome:R-RNO-416476|reactome:R-RNO-430116|reactome:R-RNO-4420097|reactome:R-RNO-512988|reactome:R-RNO-5654689|reactome:R-RNO-5654695|reactome:R-RNO-5654710|reactome:R-RNO-5654720|reactome:R-RNO-5673001|reactome:R-RNO-6811558|reactome:R-RNO-8851907|reactome:R-RNO-8853659|reactome:R-RNO-8980692|reactome:R-RNO-9009391|reactome:R-RNO-9013026|reactome:R-RNO-9013106|reactome:R-RNO-9013148|reactome:R-RNO-9013149|reactome:R-RNO-9013404|reactome:R-RNO-9013405|reactome:R-RNO-9013408|reactome:R-RNO-9013409|reactome:R-RNO-9013420|reactome:R-RNO-9013423|reactome:R-RNO-9013424|reactome:R-RNO-9027276|reactome:R-RNO-9035034|reactome:R-RNO-912526|reactome:R-RNO-912631|reactome:R-RNO-9607240|reactome:R-RNO-9696264|reactome:R-RNO-9696270|reactome:R-RNO-9696273|reactome:R-RNO-983695|mint:MINT-7157752(identity)	refseq:XP_006722005.1|refseq:NP_002593.1|refseq:XP_016880224.1|refseq:XP_016880225.1|ensembl:ENSG00000185527(gene)|ensembl:ENST00000331056(transcript)|ensembl:ENST00000571004(transcript)|ensembl:ENST00000571224(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007601"(visual perception)|go:"GO:0030507"(spectrin binding)|go:"GO:0030553"(cGMP binding)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0047555"(3',5'-cyclic-GMP phosphodiesterase activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0097381"(photoreceptor disc membrane)|interpro:IPR006952(Retinal cGMP phosphodiesterase, gamma subunit)|interpro:IPR037030|mint:P18545|rcsb pdb:3JWR|reactome:R-HSA-2485179|reactome:R-HSA-2514859|reactome:R-HSA-4086398|mint:MINT-7157744(identity)	-	-	-	figure legend:f2c|comment:homomint|comment:mint|curation depth:mimix curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/11	2014/10/16	rogid:jr9Hr1Rmtwi0SRC6OSkceJ+hSFU10116	rogid:gsjKwWpx+sGGCwYus6BYMNKbnv89606	intact-crc:742813D01945EC70|rigid:IfFbX4453mXev0qWe357gtoxlJM	false	binding-associated region:1-234(MINT-7157753)	glutathione s tranferase tag:?-?(MINT-7157772)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P18545	uniprotkb:P62994	intact:EBI-2622029|uniprotkb:Q3KP63|uniprotkb:Q7Z3U8|ensembl:ENSP00000328412|ensembl:ENSP00000458167|ensembl:ENSP00000461464	intact:EBI-401775|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q5BKA7|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSRNOP00000005347	psi-mi:cnrg_human(display_long)|uniprotkb:PDEG(gene name synonym)|uniprotkb:PDE6G(gene name)|psi-mi:PDE6G(display_short)	psi-mi:grb2_rat(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Ash(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:"MI:0096"(pull down)	Houdart et al. (2005)	pubmed:16357825|mint:MINT-7148415	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7943057|mint:MINT-7157648	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006722005.1|refseq:NP_002593.1|refseq:XP_016880224.1|refseq:XP_016880225.1|ensembl:ENSG00000185527(gene)|ensembl:ENST00000331056(transcript)|ensembl:ENST00000571004(transcript)|ensembl:ENST00000571224(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007601"(visual perception)|go:"GO:0030507"(spectrin binding)|go:"GO:0030553"(cGMP binding)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0047555"(3',5'-cyclic-GMP phosphodiesterase activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0097381"(photoreceptor disc membrane)|interpro:IPR006952(Retinal cGMP phosphodiesterase, gamma subunit)|interpro:IPR037030|mint:P18545|rcsb pdb:3JWR|reactome:R-HSA-2485179|reactome:R-HSA-2514859|reactome:R-HSA-4086398|mint:MINT-7157650(identity)	rgd:619758|refseq:NP_110473.2|ensembl:ENSRNOG00000003990(gene)|ensembl:ENSRNOT00000005347(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62994|reactome:R-RNO-109704|reactome:R-RNO-112412|reactome:R-RNO-1250347|reactome:R-RNO-1257604|reactome:R-RNO-1295596|reactome:R-RNO-1433557|reactome:R-RNO-1433559|reactome:R-RNO-167044|reactome:R-RNO-179812|reactome:R-RNO-180292|reactome:R-RNO-180336|reactome:R-RNO-182971|reactome:R-RNO-186763|reactome:R-RNO-1963640|reactome:R-RNO-1963642|reactome:R-RNO-2029482|reactome:R-RNO-210993|reactome:R-RNO-2179392|reactome:R-RNO-2424491|reactome:R-RNO-2428933|reactome:R-RNO-2730905|reactome:R-RNO-2871796|reactome:R-RNO-2871809|reactome:R-RNO-354194|reactome:R-RNO-375165|reactome:R-RNO-388841|reactome:R-RNO-389359|reactome:R-RNO-391160|reactome:R-RNO-5654688|reactome:R-RNO-5654689|reactome:R-RNO-5654693|reactome:R-RNO-5654695|reactome:R-RNO-5654699|reactome:R-RNO-5654700|reactome:R-RNO-5654704|reactome:R-RNO-5654706|reactome:R-RNO-5654710|reactome:R-RNO-5654712|reactome:R-RNO-5654719|reactome:R-RNO-5654720|reactome:R-RNO-5654726|reactome:R-RNO-5654727|reactome:R-RNO-5654732|reactome:R-RNO-5654733|reactome:R-RNO-5663213|reactome:R-RNO-5673001|reactome:R-RNO-6807004|reactome:R-RNO-6811558|reactome:R-RNO-74749|reactome:R-RNO-74751|reactome:R-RNO-8851805|reactome:R-RNO-8851907|reactome:R-RNO-8853659|reactome:R-RNO-8856828|reactome:R-RNO-8865999|reactome:R-RNO-8875555|reactome:R-RNO-8875656|reactome:R-RNO-8983432|reactome:R-RNO-9027284|reactome:R-RNO-9028731|reactome:R-RNO-912526|reactome:R-RNO-912631|reactome:R-RNO-9607240|reactome:R-RNO-9674555|reactome:R-RNO-983695|reactome:R-RNO-8856825|mint:MINT-7157658(identity)	-	-	-	figure legend:f2c|comment:homomint|comment:mint|curation depth:mimix curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/11	2014/10/16	rogid:gsjKwWpx+sGGCwYus6BYMNKbnv89606	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA410116	intact-crc:089F9CD186CECE46|rigid:kCMsgltPvJdhhK8fqelQG+wgBzk	false	glutathione s tranferase tag:?-?(MINT-7157694)	binding-associated region:1-204(MINT-7157659)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8R511	uniprotkb:P18545	intact:EBI-1111424|uniprotkb:Q75UE2|uniprotkb:Q75UE3|uniprotkb:Q75UE4|uniprotkb:Q75UE5|uniprotkb:Q75UE6	intact:EBI-2622029|uniprotkb:Q3KP63|uniprotkb:Q7Z3U8|ensembl:ENSP00000328412|ensembl:ENSP00000458167|ensembl:ENSP00000461464	psi-mi:fnbp1_rat(display_long)|uniprotkb:Fnbp1(gene name)|psi-mi:Fnbp1(display_short)|uniprotkb:Formin-binding protein 17(gene name synonym)|uniprotkb:Rapostlin(gene name synonym)|uniprotkb:Fbp17(gene name synonym)	psi-mi:cnrg_human(display_long)|uniprotkb:PDEG(gene name synonym)|uniprotkb:PDE6G(gene name)|psi-mi:PDE6G(display_short)	psi-mi:"MI:0096"(pull down)	Houdart et al. (2005)	pubmed:16357825|mint:MINT-7148415	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7943112|mint:MINT-7157789	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR027267|interpro:IPR028532|rgd:621350|refseq:NP_620269.1|interpro:IPR031160|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|go:"GO:0005764"(lysosome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0008289"(lipid binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042802"(identical protein binding)|reactome:R-RNO-8856828|reactome:R-RNO-9013148|reactome:R-RNO-9013406|reactome:R-RNO-9696270|interpro:IPR035492|interpro:IPR037449|mint:Q8R511|interpro:IPR036028|interpro:IPR011072(HR1 rho-binding repeat)|mint:MINT-7157799(identity)	refseq:XP_006722005.1|refseq:NP_002593.1|refseq:XP_016880224.1|refseq:XP_016880225.1|ensembl:ENSG00000185527(gene)|ensembl:ENST00000331056(transcript)|ensembl:ENST00000571004(transcript)|ensembl:ENST00000571224(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007601"(visual perception)|go:"GO:0030507"(spectrin binding)|go:"GO:0030553"(cGMP binding)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0047555"(3',5'-cyclic-GMP phosphodiesterase activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0097381"(photoreceptor disc membrane)|interpro:IPR006952(Retinal cGMP phosphodiesterase, gamma subunit)|interpro:IPR037030|mint:P18545|rcsb pdb:3JWR|reactome:R-HSA-2485179|reactome:R-HSA-2514859|reactome:R-HSA-4086398|mint:MINT-7157791(identity)	-	-	-	figure legend:f2c|comment:homomint|comment:mint|curation depth:mimix curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/11	2014/10/16	rogid:Ryvj22B76jaT6vpwvnmlbm5k/Yk10116	rogid:gsjKwWpx+sGGCwYus6BYMNKbnv89606	intact-crc:A5A89F8B6A04F422|rigid:2V1wAGdqhIkvOlpJobB7VTfG+n4	false	binding-associated region:3-79(MINT-7157800)	glutathione s tranferase tag:?-?(MINT-7157807)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9QY17	uniprotkb:P18545	intact:EBI-491201|uniprotkb:Q9QY18|uniprotkb:Q9QY19|uniprotkb:Q9QY20|ensembl:ENSRNOP00000060074	intact:EBI-2622029|uniprotkb:Q3KP63|uniprotkb:Q7Z3U8|ensembl:ENSP00000328412|ensembl:ENSP00000458167|ensembl:ENSP00000461464	psi-mi:pacn2_rat(display_long)|uniprotkb:Synaptic dynamin-associated protein II(gene name synonym)|uniprotkb:Syndapin-II(gene name synonym)|uniprotkb:Pacsin2(gene name)|psi-mi:Pacsin2(display_short)|uniprotkb:Syndapin-2(gene name synonym)	psi-mi:cnrg_human(display_long)|uniprotkb:PDEG(gene name synonym)|uniprotkb:PDE6G(gene name)|psi-mi:PDE6G(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Houdart et al. (2005)	pubmed:16357825|mint:MINT-7148415	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7943140|mint:MINT-7157609	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:69411|refseq:NP_570096.2|refseq:XP_017450116.1|refseq:XP_006242112.1|refseq:XP_006242113.1|refseq:XP_006242114.1|refseq:XP_006242115.1|refseq:XP_006242117.1|refseq:XP_006242120.1|refseq:XP_006242122.1|ensembl:ENSRNOG00000009756(gene)|ensembl:ENSRNOT00000067913(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008289"(lipid binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0032587"(ruffle membrane)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0048858"(cell projection morphogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0070836"(caveola assembly)|go:"GO:0097320"(plasma membrane tubulation)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|interpro:IPR027267|interpro:IPR028521|interpro:IPR031160|interpro:IPR035743|interpro:IPR036028|interpro:IPR037453|mint:Q9QY17|reactome:R-RNO-8856828|go:"GO:0072584"(caveolin-mediated endocytosis)|mint:MINT-7157611(identity)	refseq:XP_006722005.1|refseq:NP_002593.1|refseq:XP_016880224.1|refseq:XP_016880225.1|ensembl:ENSG00000185527(gene)|ensembl:ENST00000331056(transcript)|ensembl:ENST00000571004(transcript)|ensembl:ENST00000571224(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007601"(visual perception)|go:"GO:0030507"(spectrin binding)|go:"GO:0030553"(cGMP binding)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0047555"(3',5'-cyclic-GMP phosphodiesterase activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0097381"(photoreceptor disc membrane)|interpro:IPR006952(Retinal cGMP phosphodiesterase, gamma subunit)|interpro:IPR037030|mint:P18545|rcsb pdb:3JWR|reactome:R-HSA-2485179|reactome:R-HSA-2514859|reactome:R-HSA-4086398|mint:MINT-7157613(identity)	-	-	-	figure legend:f4b|comment:homomint|comment:mint|curation depth:mimix curation	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	-	2009/06/11	2014/10/16	rogid:sXAD5lVFEutV+uJ4vm0xYA6VF2E10116	rogid:gsjKwWpx+sGGCwYus6BYMNKbnv89606	intact-crc:C38B521526DE8B63|rigid:wJQbZfEdhKbkxfFXqLrrfwB79q4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)