#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q8QHK8 uniprotkb:Q6NRD3 intact:EBI-7733988|intact:UNK-5976026|uniprotkb:Q8JJC3 intact:EBI-7734031|uniprotkb:Q3L1I1|intact:MINT-7212722 psi-mi:mk08_xenla(display_long)|uniprotkb:mapk8(gene name)|psi-mi:mapk8(display_short)|uniprotkb:jnk1(gene name synonym)|uniprotkb:Stress-activated protein kinase JNK1(gene name synonym) psi-mi:sh3r1_xenla(display_long)|uniprotkb:sh3rf1(gene name)|psi-mi:sh3rf1(display_short)|uniprotkb:posh(gene name synonym)|uniprotkb:SH3 domain-containing RING finger protein 1(gene name synonym)|uniprotkb:Plenty of SH3s(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase SH3RF1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Kim et al. (2006) pubmed:16084064|mint:MINT-7208275|doi:10.1016/j.cellsig.2005.05.026 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7734026|mint:MINT-7212742 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:Q8QHK8|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007254"(JNK cascade)|go:"GO:0045202"(synapse)|go:"GO:0048511"(rhythmic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR008351(JNK MAP kinase)|interpro:IPR000719(Protein kinase, core)|refseq:NP_001080184.1|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR003527(MAP kinase, conserved site)|mint:MINT-7212744(identity) mint:Q6NRD3|go:"GO:0001764"(neuron migration)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0030027"(lamellipodium)|go:"GO:0043370"(regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2000564"(regulation of CD8-positive, alpha-beta T cell proliferation)|go:"GO:0046872"(metal ion binding)|interpro:IPR017907|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001452(Src homology-3)|refseq:NP_001084814.1|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018957|interpro:IPR035816|interpro:IPR036028|mint:MINT-7212745(identity) - comment:mint|function:"Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulating transcriptional activity (By similarity). Regulates morphogenic cell movements, controlling convergent extension during gastrulation" comment:mint comment:mint|figure legend:f1b f4a|curation depth:mimix curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2009/06/25 2014/10/16 rogid:6DX6Pxg5jS1zu9J38WnPRIr997k8355 rogid:BIWCClIsJJwoXjIlFewKR9cCY1U8355 intact-crc:03CD4B1247A5B3C6|rigid:sfkw/jGHocrUCYfotfw2PNDYgGw false flag tag:?-?(MINT-7212752) green fluorescent protein tag:?-?(MINT-7212748) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6NRD3 uniprotkb:O14964 intact:EBI-7734031|uniprotkb:Q3L1I1|intact:MINT-7212722 intact:EBI-740220|uniprotkb:Q9NR36|ensembl:ENSP00000331201|ensembl:ENSP00000504106 psi-mi:sh3r1_xenla(display_long)|uniprotkb:sh3rf1(gene name)|psi-mi:sh3rf1(display_short)|uniprotkb:posh(gene name synonym)|uniprotkb:SH3 domain-containing RING finger protein 1(gene name synonym)|uniprotkb:Plenty of SH3s(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase SH3RF1(gene name synonym) psi-mi:hgs_human(display_long)|uniprotkb:Protein pp110(gene name synonym)|uniprotkb:Hrs(gene name synonym)|uniprotkb:HGS(gene name)|psi-mi:HGS(display_short)|uniprotkb:HRS(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Kim et al. (2006) pubmed:16084064|mint:MINT-7208275|doi:10.1016/j.cellsig.2005.05.026 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7734085|mint:MINT-7212756 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:Q6NRD3|go:"GO:0001764"(neuron migration)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0030027"(lamellipodium)|go:"GO:0043370"(regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2000564"(regulation of CD8-positive, alpha-beta T cell proliferation)|go:"GO:0046872"(metal ion binding)|interpro:IPR017907|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001452(Src homology-3)|refseq:NP_001084814.1|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018957|interpro:IPR035816|interpro:IPR036028|mint:MINT-7212758(identity) refseq:NP_004703.1|dip:DIP-29050N|ensembl:ENSG00000185359(gene)|ensembl:ENST00000329138(transcript)|ensembl:ENST00000676546(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010324"(membrane invagination)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0016197"(endosomal transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033565"(ESCRT-0 complex)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043405"(regulation of MAP kinase activity)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0097013"(phagocytic vesicle lumen)|go:"GO:1903543"(positive regulation of exosomal secretion)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR002014(VHS)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017073(Ubiquitin binding protein, Hrs/VPS27)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR024641|mint:O14964|rcsb pdb:2D3G|rcsb pdb:3F1I|rcsb pdb:3OBQ|rcsb pdb:3ZYQ|rcsb pdb:4AVX|reactome:R-HSA-182971|reactome:R-HSA-432720|reactome:R-HSA-5689880|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-9013420|reactome:R-HSA-917729|reactome:R-HSA-9635644|reactome:R-HSA-9636383|reactome:R-HSA-9706019|mint:MINT-7212762(identity) - comment:mint - figure legend:f4a|comment:mint|curation depth:mimix curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2009/06/25 2014/10/16 rogid:BIWCClIsJJwoXjIlFewKR9cCY1U8355 rogid:z/AnREuqEpyJ9/Zj6JFCJCJem1I9606 intact-crc:DC525EEBB24F3EFF|rigid:/mJAukxrrtkdAy6IGzi0Gcp2DV4 false green fluorescent protein tag:?-?(MINT-7212759) ha tag:?-?(MINT-7212763) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6NRD3 uniprotkb:O14964 intact:EBI-7734031|uniprotkb:Q3L1I1|intact:MINT-7212722 intact:EBI-740220|uniprotkb:Q9NR36|ensembl:ENSP00000331201|ensembl:ENSP00000504106 psi-mi:sh3r1_xenla(display_long)|uniprotkb:sh3rf1(gene name)|psi-mi:sh3rf1(display_short)|uniprotkb:posh(gene name synonym)|uniprotkb:SH3 domain-containing RING finger protein 1(gene name synonym)|uniprotkb:Plenty of SH3s(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase SH3RF1(gene name synonym) psi-mi:hgs_human(display_long)|uniprotkb:Protein pp110(gene name synonym)|uniprotkb:Hrs(gene name synonym)|uniprotkb:HGS(gene name)|psi-mi:HGS(display_short)|uniprotkb:HRS(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Kim et al. (2006) pubmed:16084064|mint:MINT-7208275|doi:10.1016/j.cellsig.2005.05.026 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7734158|mint:MINT-7212789 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:Q6NRD3|go:"GO:0001764"(neuron migration)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0030027"(lamellipodium)|go:"GO:0043370"(regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2000564"(regulation of CD8-positive, alpha-beta T cell proliferation)|go:"GO:0046872"(metal ion binding)|interpro:IPR017907|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001452(Src homology-3)|refseq:NP_001084814.1|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018957|interpro:IPR035816|interpro:IPR036028|mint:MINT-7212791(identity) refseq:NP_004703.1|dip:DIP-29050N|ensembl:ENSG00000185359(gene)|ensembl:ENST00000329138(transcript)|ensembl:ENST00000676546(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010324"(membrane invagination)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0016197"(endosomal transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033565"(ESCRT-0 complex)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043405"(regulation of MAP kinase activity)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0097013"(phagocytic vesicle lumen)|go:"GO:1903543"(positive regulation of exosomal secretion)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR002014(VHS)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017073(Ubiquitin binding protein, Hrs/VPS27)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR024641|mint:O14964|rcsb pdb:2D3G|rcsb pdb:3F1I|rcsb pdb:3OBQ|rcsb pdb:3ZYQ|rcsb pdb:4AVX|reactome:R-HSA-182971|reactome:R-HSA-432720|reactome:R-HSA-5689880|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-9013420|reactome:R-HSA-917729|reactome:R-HSA-9635644|reactome:R-HSA-9636383|reactome:R-HSA-9706019|mint:MINT-7212795(identity) - comment:mint - figure legend:f4c|comment:mint|curation depth:mimix curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2009/06/25 2014/10/16 rogid:BIWCClIsJJwoXjIlFewKR9cCY1U8355 rogid:z/AnREuqEpyJ9/Zj6JFCJCJem1I9606 intact-crc:E8F542A72659CE89|rigid:/mJAukxrrtkdAy6IGzi0Gcp2DV4 false binding-associated region:?-?(MINT-7212802)|green fluorescent protein tag:?-?(MINT-7212792) ha tag:?-?(MINT-7212796) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6NRD3 uniprotkb:O14964 intact:EBI-7734031|uniprotkb:Q3L1I1|intact:MINT-7212722 intact:EBI-740220|uniprotkb:Q9NR36|ensembl:ENSP00000331201|ensembl:ENSP00000504106 psi-mi:sh3r1_xenla(display_long)|uniprotkb:sh3rf1(gene name)|psi-mi:sh3rf1(display_short)|uniprotkb:posh(gene name synonym)|uniprotkb:SH3 domain-containing RING finger protein 1(gene name synonym)|uniprotkb:Plenty of SH3s(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase SH3RF1(gene name synonym) psi-mi:hgs_human(display_long)|uniprotkb:Protein pp110(gene name synonym)|uniprotkb:Hrs(gene name synonym)|uniprotkb:HGS(gene name)|psi-mi:HGS(display_short)|uniprotkb:HRS(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Kim et al. (2006) pubmed:16084064|mint:MINT-7208275|doi:10.1016/j.cellsig.2005.05.026 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7734124|mint:MINT-7212770 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:Q6NRD3|go:"GO:0001764"(neuron migration)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0030027"(lamellipodium)|go:"GO:0043370"(regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2000564"(regulation of CD8-positive, alpha-beta T cell proliferation)|go:"GO:0046872"(metal ion binding)|interpro:IPR017907|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001452(Src homology-3)|refseq:NP_001084814.1|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018957|interpro:IPR035816|interpro:IPR036028|mint:MINT-7212776(identity) refseq:NP_004703.1|dip:DIP-29050N|ensembl:ENSG00000185359(gene)|ensembl:ENST00000329138(transcript)|ensembl:ENST00000676546(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010324"(membrane invagination)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0016197"(endosomal transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033565"(ESCRT-0 complex)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043405"(regulation of MAP kinase activity)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0097013"(phagocytic vesicle lumen)|go:"GO:1903543"(positive regulation of exosomal secretion)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR002014(VHS)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017073(Ubiquitin binding protein, Hrs/VPS27)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR024641|mint:O14964|rcsb pdb:2D3G|rcsb pdb:3F1I|rcsb pdb:3OBQ|rcsb pdb:3ZYQ|rcsb pdb:4AVX|reactome:R-HSA-182971|reactome:R-HSA-432720|reactome:R-HSA-5689880|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-9013420|reactome:R-HSA-917729|reactome:R-HSA-9635644|reactome:R-HSA-9636383|reactome:R-HSA-9706019|mint:MINT-7212772(identity) - comment:mint - figure legend:f6a|comment:mint|curation depth:mimix curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2009/06/25 2014/10/16 rogid:BIWCClIsJJwoXjIlFewKR9cCY1U8355 rogid:z/AnREuqEpyJ9/Zj6JFCJCJem1I9606 intact-crc:CAD6FB26041797FB|rigid:/mJAukxrrtkdAy6IGzi0Gcp2DV4 false green fluorescent protein tag:?-?(MINT-7212777) ha tag:?-?(MINT-7212773) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)