#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P00523 uniprotkb:O88703 intact:EBI-848039|uniprotkb:Q90992|uniprotkb:Q90993|uniprotkb:Q91343|uniprotkb:Q91345|uniprotkb:Q92013|uniprotkb:Q98915|ensembl:ENSGALP00000049896|ensembl:ENSGALP00000054990|ensembl:ENSGALP00000068298 intact:EBI-771231|uniprotkb:O70506|ensembl:ENSMUSP00000020581|ensembl:ENSMUSP00000097113 psi-mi:src_chick(display_long)|uniprotkb:SRC(gene name)|psi-mi:SRC(display_short)|uniprotkb:pp60c-src(gene name synonym)|uniprotkb:Proto-oncogene c-Src(gene name synonym) psi-mi:hcn2_mouse(display_long)|uniprotkb:Brain cyclic nucleotide-gated channel 2(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 1(gene name synonym)|uniprotkb:Bcng2(gene name synonym)|uniprotkb:Hac1(gene name synonym)|uniprotkb:Hcn2(gene name)|psi-mi:Hcn2(display_short) psi-mi:"MI:0018"(two hybrid) Zong et al. (2005) pubmed:16079136|mint:MINT-7208279|doi:10.1074/jbc.M506544200 taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7729832|mint:MINT-7212596 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_990788.2|dip:DIP-449N|refseq:XP_015151834.1|ensembl:ENSGALG00000003855(gene)|ensembl:ENSGALT00000061823(transcript)|ensembl:ENSGALT00000070498(transcript)|ensembl:ENSGALT00000093274(transcript)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0020037"(heme binding)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036035"(osteoclast development)|go:"GO:0045087"(innate immune response)|go:"GO:0045453"(bone resorption)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071253"(connexin binding)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036028|interpro:IPR036860|mint:P00523|rcsb pdb:1F1W|rcsb pdb:1F2F|rcsb pdb:1NLO|rcsb pdb:1NLP|rcsb pdb:1P13|rcsb pdb:1PRL|rcsb pdb:1PRM|rcsb pdb:1RLP|rcsb pdb:1RLQ|rcsb pdb:1SRL|rcsb pdb:1SRM|rcsb pdb:2HWO|rcsb pdb:2HWP|rcsb pdb:2OIQ|rcsb pdb:2PTK|rcsb pdb:2QI8|rcsb pdb:2QLQ|rcsb pdb:2QQ7|rcsb pdb:3D7T|rcsb pdb:3D7U|rcsb pdb:3DQW|rcsb pdb:3DQX|rcsb pdb:3EL7|rcsb pdb:3EL8|rcsb pdb:3EN4|rcsb pdb:3EN5|rcsb pdb:3EN6|rcsb pdb:3EN7|rcsb pdb:3F3T|rcsb pdb:3F3U|rcsb pdb:3F3V|rcsb pdb:3F3W|rcsb pdb:3F6X|rcsb pdb:3FJ5|rcsb pdb:3G5D|rcsb pdb:3G6G|rcsb pdb:3G6H|rcsb pdb:3GEQ|rcsb pdb:3LOK|rcsb pdb:3OEZ|rcsb pdb:3OF0|rcsb pdb:3QLF|rcsb pdb:3QLG|rcsb pdb:3SVV|rcsb pdb:3TZ7|rcsb pdb:3TZ8|rcsb pdb:3TZ9|rcsb pdb:3U4W|rcsb pdb:3U51|rcsb pdb:3UQF|rcsb pdb:3UQG|rcsb pdb:4AGW|rcsb pdb:4DGG|rcsb pdb:4FIC|rcsb pdb:4HVU|rcsb pdb:4HVV|rcsb pdb:4HVW|rcsb pdb:4JZ3|rcsb pdb:4JZ4|rcsb pdb:4LE9|rcsb pdb:4LGG|rcsb pdb:4LGH|rcsb pdb:4MCV|rcsb pdb:4O2P|rcsb pdb:4OML|rcsb pdb:4OMM|rcsb pdb:4OMN|rcsb pdb:4OMO|rcsb pdb:4OMP|rcsb pdb:4OMQ|rcsb pdb:4QT7|rcsb pdb:4RTU|rcsb pdb:4RTV|rcsb pdb:4RTW|rcsb pdb:4RTX|rcsb pdb:4RTY|rcsb pdb:4RTZ|rcsb pdb:4U5J|rcsb pdb:4YBJ|rcsb pdb:4YBK|rcsb pdb:5BMM|rcsb pdb:5D10|rcsb pdb:5D11|rcsb pdb:5D12|rcsb pdb:5EC7|rcsb pdb:5ECA|rcsb pdb:5I11|rcsb pdb:5J5S|rcsb pdb:5K9I|rcsb pdb:5OAV|rcsb pdb:5OB0|rcsb pdb:5OB1|rcsb pdb:5OB2|rcsb pdb:5SWH|rcsb pdb:5SYS|rcsb pdb:5T0P|rcsb pdb:5TEH|rcsb pdb:5XP5|rcsb pdb:5XP7|rcsb pdb:6HVE|rcsb pdb:6HVF|rcsb pdb:6L8L|rcsb pdb:6WIW|rcsb pdb:6XVM|rcsb pdb:6XVN|rcsb pdb:6XVO|rcsb pdb:6XX2|rcsb pdb:6XX3|rcsb pdb:6XX4|rcsb pdb:6XX5|reactome:R-GGA-1227986|reactome:R-GGA-1251985|reactome:R-GGA-1253288|reactome:R-GGA-1257604|reactome:R-GGA-1433557|reactome:R-GGA-180292|reactome:R-GGA-186763|reactome:R-GGA-191650|reactome:R-GGA-2029481|reactome:R-GGA-210990|reactome:R-GGA-354192|reactome:R-GGA-354194|reactome:R-GGA-372708|reactome:R-GGA-389356|reactome:R-GGA-389513|reactome:R-GGA-3928662|reactome:R-GGA-3928663|reactome:R-GGA-3928664|reactome:R-GGA-3928665|reactome:R-GGA-418592|reactome:R-GGA-418594|reactome:R-GGA-418885|reactome:R-GGA-430116|reactome:R-GGA-437239|reactome:R-GGA-4420097|reactome:R-GGA-456926|reactome:R-GGA-5218921|reactome:R-GGA-5674135|reactome:R-GGA-6811558|reactome:R-GGA-8853659|reactome:R-GGA-8874081|reactome:R-GGA-8941858|reactome:R-GGA-9009391|mint:MINT-7212598(identity) refseq:NP_032252.1|dip:DIP-29326N|ensembl:ENSMUSG00000020331(gene)|ensembl:ENSMUST00000020581(transcript)|ensembl:ENSMUST00000099513(transcript)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030552"(cAMP binding)|go:"GO:0032590"(dendrite membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|mint:O88703|rcsb pdb:1Q3E|rcsb pdb:1Q43|rcsb pdb:1Q5O|rcsb pdb:2Q0A|rcsb pdb:3BPZ|rcsb pdb:3ETQ|rcsb pdb:3FFQ|rcsb pdb:4EQF|rcsb pdb:5JON|rcsb pdb:5KHG|rcsb pdb:5KHH|rcsb pdb:5KHI|rcsb pdb:5KHJ|rcsb pdb:5KHK|reactome:R-MMU-1296061|mint:MINT-7212599(identity) - - - figure legend:f4b|comment:homomint|comment:mint|curation depth:mimix curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2009/06/25 2014/10/16 rogid:4zMmRUOi44prLCXBJNuTuFIMkr49031 rogid:+2OZtagUBYgKm6J6eqLZzEkUkvg10090 intact-crc:BA585ABF278D16FF|rigid:/cm3hgULSL+FInLgjMhZjfE47KI false - binding-associated region:449-646(MINT-7212602) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P00523 uniprotkb:O88703 intact:EBI-848039|uniprotkb:Q90992|uniprotkb:Q90993|uniprotkb:Q91343|uniprotkb:Q91345|uniprotkb:Q92013|uniprotkb:Q98915|ensembl:ENSGALP00000049896|ensembl:ENSGALP00000054990|ensembl:ENSGALP00000068298 intact:EBI-771231|uniprotkb:O70506|ensembl:ENSMUSP00000020581|ensembl:ENSMUSP00000097113 psi-mi:src_chick(display_long)|uniprotkb:SRC(gene name)|psi-mi:SRC(display_short)|uniprotkb:pp60c-src(gene name synonym)|uniprotkb:Proto-oncogene c-Src(gene name synonym) psi-mi:hcn2_mouse(display_long)|uniprotkb:Brain cyclic nucleotide-gated channel 2(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 1(gene name synonym)|uniprotkb:Bcng2(gene name synonym)|uniprotkb:Hac1(gene name synonym)|uniprotkb:Hcn2(gene name)|psi-mi:Hcn2(display_short) psi-mi:"MI:0018"(two hybrid) Zong et al. (2005) pubmed:16079136|mint:MINT-7208279|doi:10.1074/jbc.M506544200 taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7729890|mint:MINT-7212607 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_990788.2|dip:DIP-449N|refseq:XP_015151834.1|ensembl:ENSGALG00000003855(gene)|ensembl:ENSGALT00000061823(transcript)|ensembl:ENSGALT00000070498(transcript)|ensembl:ENSGALT00000093274(transcript)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0020037"(heme binding)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036035"(osteoclast development)|go:"GO:0045087"(innate immune response)|go:"GO:0045453"(bone resorption)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071253"(connexin binding)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036028|interpro:IPR036860|mint:P00523|rcsb pdb:1F1W|rcsb pdb:1F2F|rcsb pdb:1NLO|rcsb pdb:1NLP|rcsb pdb:1P13|rcsb pdb:1PRL|rcsb pdb:1PRM|rcsb pdb:1RLP|rcsb pdb:1RLQ|rcsb pdb:1SRL|rcsb pdb:1SRM|rcsb pdb:2HWO|rcsb pdb:2HWP|rcsb pdb:2OIQ|rcsb pdb:2PTK|rcsb pdb:2QI8|rcsb pdb:2QLQ|rcsb pdb:2QQ7|rcsb pdb:3D7T|rcsb pdb:3D7U|rcsb pdb:3DQW|rcsb pdb:3DQX|rcsb pdb:3EL7|rcsb pdb:3EL8|rcsb pdb:3EN4|rcsb pdb:3EN5|rcsb pdb:3EN6|rcsb pdb:3EN7|rcsb pdb:3F3T|rcsb pdb:3F3U|rcsb pdb:3F3V|rcsb pdb:3F3W|rcsb pdb:3F6X|rcsb pdb:3FJ5|rcsb pdb:3G5D|rcsb pdb:3G6G|rcsb pdb:3G6H|rcsb pdb:3GEQ|rcsb pdb:3LOK|rcsb pdb:3OEZ|rcsb pdb:3OF0|rcsb pdb:3QLF|rcsb pdb:3QLG|rcsb pdb:3SVV|rcsb pdb:3TZ7|rcsb pdb:3TZ8|rcsb pdb:3TZ9|rcsb pdb:3U4W|rcsb pdb:3U51|rcsb pdb:3UQF|rcsb pdb:3UQG|rcsb pdb:4AGW|rcsb pdb:4DGG|rcsb pdb:4FIC|rcsb pdb:4HVU|rcsb pdb:4HVV|rcsb pdb:4HVW|rcsb pdb:4JZ3|rcsb pdb:4JZ4|rcsb pdb:4LE9|rcsb pdb:4LGG|rcsb pdb:4LGH|rcsb pdb:4MCV|rcsb pdb:4O2P|rcsb pdb:4OML|rcsb pdb:4OMM|rcsb pdb:4OMN|rcsb pdb:4OMO|rcsb pdb:4OMP|rcsb pdb:4OMQ|rcsb pdb:4QT7|rcsb pdb:4RTU|rcsb pdb:4RTV|rcsb pdb:4RTW|rcsb pdb:4RTX|rcsb pdb:4RTY|rcsb pdb:4RTZ|rcsb pdb:4U5J|rcsb pdb:4YBJ|rcsb pdb:4YBK|rcsb pdb:5BMM|rcsb pdb:5D10|rcsb pdb:5D11|rcsb pdb:5D12|rcsb pdb:5EC7|rcsb pdb:5ECA|rcsb pdb:5I11|rcsb pdb:5J5S|rcsb pdb:5K9I|rcsb pdb:5OAV|rcsb pdb:5OB0|rcsb pdb:5OB1|rcsb pdb:5OB2|rcsb pdb:5SWH|rcsb pdb:5SYS|rcsb pdb:5T0P|rcsb pdb:5TEH|rcsb pdb:5XP5|rcsb pdb:5XP7|rcsb pdb:6HVE|rcsb pdb:6HVF|rcsb pdb:6L8L|rcsb pdb:6WIW|rcsb pdb:6XVM|rcsb pdb:6XVN|rcsb pdb:6XVO|rcsb pdb:6XX2|rcsb pdb:6XX3|rcsb pdb:6XX4|rcsb pdb:6XX5|reactome:R-GGA-1227986|reactome:R-GGA-1251985|reactome:R-GGA-1253288|reactome:R-GGA-1257604|reactome:R-GGA-1433557|reactome:R-GGA-180292|reactome:R-GGA-186763|reactome:R-GGA-191650|reactome:R-GGA-2029481|reactome:R-GGA-210990|reactome:R-GGA-354192|reactome:R-GGA-354194|reactome:R-GGA-372708|reactome:R-GGA-389356|reactome:R-GGA-389513|reactome:R-GGA-3928662|reactome:R-GGA-3928663|reactome:R-GGA-3928664|reactome:R-GGA-3928665|reactome:R-GGA-418592|reactome:R-GGA-418594|reactome:R-GGA-418885|reactome:R-GGA-430116|reactome:R-GGA-437239|reactome:R-GGA-4420097|reactome:R-GGA-456926|reactome:R-GGA-5218921|reactome:R-GGA-5674135|reactome:R-GGA-6811558|reactome:R-GGA-8853659|reactome:R-GGA-8874081|reactome:R-GGA-8941858|reactome:R-GGA-9009391|mint:MINT-7212613(identity) refseq:NP_032252.1|dip:DIP-29326N|ensembl:ENSMUSG00000020331(gene)|ensembl:ENSMUST00000020581(transcript)|ensembl:ENSMUST00000099513(transcript)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030552"(cAMP binding)|go:"GO:0032590"(dendrite membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|mint:O88703|rcsb pdb:1Q3E|rcsb pdb:1Q43|rcsb pdb:1Q5O|rcsb pdb:2Q0A|rcsb pdb:3BPZ|rcsb pdb:3ETQ|rcsb pdb:3FFQ|rcsb pdb:4EQF|rcsb pdb:5JON|rcsb pdb:5KHG|rcsb pdb:5KHH|rcsb pdb:5KHI|rcsb pdb:5KHJ|rcsb pdb:5KHK|reactome:R-MMU-1296061|mint:MINT-7212609(identity) - - - figure legend:f4b|comment:homomint|comment:mint|curation depth:mimix curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2009/06/25 2014/10/16 rogid:4zMmRUOi44prLCXBJNuTuFIMkr49031 rogid:+2OZtagUBYgKm6J6eqLZzEkUkvg10090 intact-crc:2A67658F5089F3B3|rigid:/cm3hgULSL+FInLgjMhZjfE47KI false binding-associated region:81-139(MINT-7212616) binding-associated region:449-646(MINT-7212610) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O88703 uniprotkb:P00523 intact:EBI-771231|uniprotkb:O70506|ensembl:ENSMUSP00000020581|ensembl:ENSMUSP00000097113 intact:EBI-848039|uniprotkb:Q90992|uniprotkb:Q90993|uniprotkb:Q91343|uniprotkb:Q91345|uniprotkb:Q92013|uniprotkb:Q98915|ensembl:ENSGALP00000049896|ensembl:ENSGALP00000054990|ensembl:ENSGALP00000068298 psi-mi:hcn2_mouse(display_long)|uniprotkb:Brain cyclic nucleotide-gated channel 2(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 1(gene name synonym)|uniprotkb:Bcng2(gene name synonym)|uniprotkb:Hac1(gene name synonym)|uniprotkb:Hcn2(gene name)|psi-mi:Hcn2(display_short) psi-mi:src_chick(display_long)|uniprotkb:SRC(gene name)|psi-mi:SRC(display_short)|uniprotkb:pp60c-src(gene name synonym)|uniprotkb:Proto-oncogene c-Src(gene name synonym) psi-mi:"MI:0096"(pull down) Zong et al. (2005) pubmed:16079136|mint:MINT-7208279|doi:10.1074/jbc.M506544200 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7729919|mint:MINT-7212620 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_032252.1|dip:DIP-29326N|ensembl:ENSMUSG00000020331(gene)|ensembl:ENSMUST00000020581(transcript)|ensembl:ENSMUST00000099513(transcript)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030552"(cAMP binding)|go:"GO:0032590"(dendrite membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|mint:O88703|rcsb pdb:1Q3E|rcsb pdb:1Q43|rcsb pdb:1Q5O|rcsb pdb:2Q0A|rcsb pdb:3BPZ|rcsb pdb:3ETQ|rcsb pdb:3FFQ|rcsb pdb:4EQF|rcsb pdb:5JON|rcsb pdb:5KHG|rcsb pdb:5KHH|rcsb pdb:5KHI|rcsb pdb:5KHJ|rcsb pdb:5KHK|reactome:R-MMU-1296061|mint:MINT-7212627(identity) refseq:NP_990788.2|dip:DIP-449N|refseq:XP_015151834.1|ensembl:ENSGALG00000003855(gene)|ensembl:ENSGALT00000061823(transcript)|ensembl:ENSGALT00000070498(transcript)|ensembl:ENSGALT00000093274(transcript)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0020037"(heme binding)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036035"(osteoclast development)|go:"GO:0045087"(innate immune response)|go:"GO:0045453"(bone resorption)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071253"(connexin binding)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036028|interpro:IPR036860|mint:P00523|rcsb pdb:1F1W|rcsb pdb:1F2F|rcsb pdb:1NLO|rcsb pdb:1NLP|rcsb pdb:1P13|rcsb pdb:1PRL|rcsb pdb:1PRM|rcsb pdb:1RLP|rcsb pdb:1RLQ|rcsb pdb:1SRL|rcsb pdb:1SRM|rcsb pdb:2HWO|rcsb pdb:2HWP|rcsb pdb:2OIQ|rcsb pdb:2PTK|rcsb pdb:2QI8|rcsb pdb:2QLQ|rcsb pdb:2QQ7|rcsb pdb:3D7T|rcsb pdb:3D7U|rcsb pdb:3DQW|rcsb pdb:3DQX|rcsb pdb:3EL7|rcsb pdb:3EL8|rcsb pdb:3EN4|rcsb pdb:3EN5|rcsb pdb:3EN6|rcsb pdb:3EN7|rcsb pdb:3F3T|rcsb pdb:3F3U|rcsb pdb:3F3V|rcsb pdb:3F3W|rcsb pdb:3F6X|rcsb pdb:3FJ5|rcsb pdb:3G5D|rcsb pdb:3G6G|rcsb pdb:3G6H|rcsb pdb:3GEQ|rcsb pdb:3LOK|rcsb pdb:3OEZ|rcsb pdb:3OF0|rcsb pdb:3QLF|rcsb pdb:3QLG|rcsb pdb:3SVV|rcsb pdb:3TZ7|rcsb pdb:3TZ8|rcsb pdb:3TZ9|rcsb pdb:3U4W|rcsb pdb:3U51|rcsb pdb:3UQF|rcsb pdb:3UQG|rcsb pdb:4AGW|rcsb pdb:4DGG|rcsb pdb:4FIC|rcsb pdb:4HVU|rcsb pdb:4HVV|rcsb pdb:4HVW|rcsb pdb:4JZ3|rcsb pdb:4JZ4|rcsb pdb:4LE9|rcsb pdb:4LGG|rcsb pdb:4LGH|rcsb pdb:4MCV|rcsb pdb:4O2P|rcsb pdb:4OML|rcsb pdb:4OMM|rcsb pdb:4OMN|rcsb pdb:4OMO|rcsb pdb:4OMP|rcsb pdb:4OMQ|rcsb pdb:4QT7|rcsb pdb:4RTU|rcsb pdb:4RTV|rcsb pdb:4RTW|rcsb pdb:4RTX|rcsb pdb:4RTY|rcsb pdb:4RTZ|rcsb pdb:4U5J|rcsb pdb:4YBJ|rcsb pdb:4YBK|rcsb pdb:5BMM|rcsb pdb:5D10|rcsb pdb:5D11|rcsb pdb:5D12|rcsb pdb:5EC7|rcsb pdb:5ECA|rcsb pdb:5I11|rcsb pdb:5J5S|rcsb pdb:5K9I|rcsb pdb:5OAV|rcsb pdb:5OB0|rcsb pdb:5OB1|rcsb pdb:5OB2|rcsb pdb:5SWH|rcsb pdb:5SYS|rcsb pdb:5T0P|rcsb pdb:5TEH|rcsb pdb:5XP5|rcsb pdb:5XP7|rcsb pdb:6HVE|rcsb pdb:6HVF|rcsb pdb:6L8L|rcsb pdb:6WIW|rcsb pdb:6XVM|rcsb pdb:6XVN|rcsb pdb:6XVO|rcsb pdb:6XX2|rcsb pdb:6XX3|rcsb pdb:6XX4|rcsb pdb:6XX5|reactome:R-GGA-1227986|reactome:R-GGA-1251985|reactome:R-GGA-1253288|reactome:R-GGA-1257604|reactome:R-GGA-1433557|reactome:R-GGA-180292|reactome:R-GGA-186763|reactome:R-GGA-191650|reactome:R-GGA-2029481|reactome:R-GGA-210990|reactome:R-GGA-354192|reactome:R-GGA-354194|reactome:R-GGA-372708|reactome:R-GGA-389356|reactome:R-GGA-389513|reactome:R-GGA-3928662|reactome:R-GGA-3928663|reactome:R-GGA-3928664|reactome:R-GGA-3928665|reactome:R-GGA-418592|reactome:R-GGA-418594|reactome:R-GGA-418885|reactome:R-GGA-430116|reactome:R-GGA-437239|reactome:R-GGA-4420097|reactome:R-GGA-456926|reactome:R-GGA-5218921|reactome:R-GGA-5674135|reactome:R-GGA-6811558|reactome:R-GGA-8853659|reactome:R-GGA-8874081|reactome:R-GGA-8941858|reactome:R-GGA-9009391|mint:MINT-7212622(identity) - - - figure legend:f4c|comment:homomint|comment:mint|curation depth:mimix curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/06/25 2014/10/16 rogid:+2OZtagUBYgKm6J6eqLZzEkUkvg10090 rogid:4zMmRUOi44prLCXBJNuTuFIMkr49031 intact-crc:3503E858C7F68BF5|rigid:/cm3hgULSL+FInLgjMhZjfE47KI false glutathione s tranferase tag:?-?(MINT-7212634)|binding-associated region:449-646(MINT-7212628) myc tag:?-?(MINT-7212637) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P00523 uniprotkb:O88703 intact:EBI-848039|uniprotkb:Q90992|uniprotkb:Q90993|uniprotkb:Q91343|uniprotkb:Q91345|uniprotkb:Q92013|uniprotkb:Q98915|ensembl:ENSGALP00000049896|ensembl:ENSGALP00000054990|ensembl:ENSGALP00000068298 intact:EBI-771231|uniprotkb:O70506|ensembl:ENSMUSP00000020581|ensembl:ENSMUSP00000097113 psi-mi:src_chick(display_long)|uniprotkb:SRC(gene name)|psi-mi:SRC(display_short)|uniprotkb:pp60c-src(gene name synonym)|uniprotkb:Proto-oncogene c-Src(gene name synonym) psi-mi:hcn2_mouse(display_long)|uniprotkb:Brain cyclic nucleotide-gated channel 2(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 1(gene name synonym)|uniprotkb:Bcng2(gene name synonym)|uniprotkb:Hac1(gene name synonym)|uniprotkb:Hcn2(gene name)|psi-mi:Hcn2(display_short) psi-mi:"MI:0096"(pull down) Zong et al. (2005) pubmed:16079136|mint:MINT-7208279|doi:10.1074/jbc.M506544200 taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7729980|mint:MINT-7212640 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_990788.2|dip:DIP-449N|refseq:XP_015151834.1|ensembl:ENSGALG00000003855(gene)|ensembl:ENSGALT00000061823(transcript)|ensembl:ENSGALT00000070498(transcript)|ensembl:ENSGALT00000093274(transcript)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0020037"(heme binding)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036035"(osteoclast development)|go:"GO:0045087"(innate immune response)|go:"GO:0045453"(bone resorption)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071253"(connexin binding)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036028|interpro:IPR036860|mint:P00523|rcsb pdb:1F1W|rcsb pdb:1F2F|rcsb pdb:1NLO|rcsb pdb:1NLP|rcsb pdb:1P13|rcsb pdb:1PRL|rcsb pdb:1PRM|rcsb pdb:1RLP|rcsb pdb:1RLQ|rcsb pdb:1SRL|rcsb pdb:1SRM|rcsb pdb:2HWO|rcsb pdb:2HWP|rcsb pdb:2OIQ|rcsb pdb:2PTK|rcsb pdb:2QI8|rcsb pdb:2QLQ|rcsb pdb:2QQ7|rcsb pdb:3D7T|rcsb pdb:3D7U|rcsb pdb:3DQW|rcsb pdb:3DQX|rcsb pdb:3EL7|rcsb pdb:3EL8|rcsb pdb:3EN4|rcsb pdb:3EN5|rcsb pdb:3EN6|rcsb pdb:3EN7|rcsb pdb:3F3T|rcsb pdb:3F3U|rcsb pdb:3F3V|rcsb pdb:3F3W|rcsb pdb:3F6X|rcsb pdb:3FJ5|rcsb pdb:3G5D|rcsb pdb:3G6G|rcsb pdb:3G6H|rcsb pdb:3GEQ|rcsb pdb:3LOK|rcsb pdb:3OEZ|rcsb pdb:3OF0|rcsb pdb:3QLF|rcsb pdb:3QLG|rcsb pdb:3SVV|rcsb pdb:3TZ7|rcsb pdb:3TZ8|rcsb pdb:3TZ9|rcsb pdb:3U4W|rcsb pdb:3U51|rcsb pdb:3UQF|rcsb pdb:3UQG|rcsb pdb:4AGW|rcsb pdb:4DGG|rcsb pdb:4FIC|rcsb pdb:4HVU|rcsb pdb:4HVV|rcsb pdb:4HVW|rcsb pdb:4JZ3|rcsb pdb:4JZ4|rcsb pdb:4LE9|rcsb pdb:4LGG|rcsb pdb:4LGH|rcsb pdb:4MCV|rcsb pdb:4O2P|rcsb pdb:4OML|rcsb pdb:4OMM|rcsb pdb:4OMN|rcsb pdb:4OMO|rcsb pdb:4OMP|rcsb pdb:4OMQ|rcsb pdb:4QT7|rcsb pdb:4RTU|rcsb pdb:4RTV|rcsb pdb:4RTW|rcsb pdb:4RTX|rcsb pdb:4RTY|rcsb pdb:4RTZ|rcsb pdb:4U5J|rcsb pdb:4YBJ|rcsb pdb:4YBK|rcsb pdb:5BMM|rcsb pdb:5D10|rcsb pdb:5D11|rcsb pdb:5D12|rcsb pdb:5EC7|rcsb pdb:5ECA|rcsb pdb:5I11|rcsb pdb:5J5S|rcsb pdb:5K9I|rcsb pdb:5OAV|rcsb pdb:5OB0|rcsb pdb:5OB1|rcsb pdb:5OB2|rcsb pdb:5SWH|rcsb pdb:5SYS|rcsb pdb:5T0P|rcsb pdb:5TEH|rcsb pdb:5XP5|rcsb pdb:5XP7|rcsb pdb:6HVE|rcsb pdb:6HVF|rcsb pdb:6L8L|rcsb pdb:6WIW|rcsb pdb:6XVM|rcsb pdb:6XVN|rcsb pdb:6XVO|rcsb pdb:6XX2|rcsb pdb:6XX3|rcsb pdb:6XX4|rcsb pdb:6XX5|reactome:R-GGA-1227986|reactome:R-GGA-1251985|reactome:R-GGA-1253288|reactome:R-GGA-1257604|reactome:R-GGA-1433557|reactome:R-GGA-180292|reactome:R-GGA-186763|reactome:R-GGA-191650|reactome:R-GGA-2029481|reactome:R-GGA-210990|reactome:R-GGA-354192|reactome:R-GGA-354194|reactome:R-GGA-372708|reactome:R-GGA-389356|reactome:R-GGA-389513|reactome:R-GGA-3928662|reactome:R-GGA-3928663|reactome:R-GGA-3928664|reactome:R-GGA-3928665|reactome:R-GGA-418592|reactome:R-GGA-418594|reactome:R-GGA-418885|reactome:R-GGA-430116|reactome:R-GGA-437239|reactome:R-GGA-4420097|reactome:R-GGA-456926|reactome:R-GGA-5218921|reactome:R-GGA-5674135|reactome:R-GGA-6811558|reactome:R-GGA-8853659|reactome:R-GGA-8874081|reactome:R-GGA-8941858|reactome:R-GGA-9009391|mint:MINT-7212648(identity) refseq:NP_032252.1|dip:DIP-29326N|ensembl:ENSMUSG00000020331(gene)|ensembl:ENSMUST00000020581(transcript)|ensembl:ENSMUST00000099513(transcript)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030552"(cAMP binding)|go:"GO:0032590"(dendrite membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|mint:O88703|rcsb pdb:1Q3E|rcsb pdb:1Q43|rcsb pdb:1Q5O|rcsb pdb:2Q0A|rcsb pdb:3BPZ|rcsb pdb:3ETQ|rcsb pdb:3FFQ|rcsb pdb:4EQF|rcsb pdb:5JON|rcsb pdb:5KHG|rcsb pdb:5KHH|rcsb pdb:5KHI|rcsb pdb:5KHJ|rcsb pdb:5KHK|reactome:R-MMU-1296061|mint:MINT-7212642(identity) - - - figure legend:f4d|comment:homomint|comment:mint|curation depth:mimix curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/06/25 2014/10/16 rogid:4zMmRUOi44prLCXBJNuTuFIMkr49031 rogid:+2OZtagUBYgKm6J6eqLZzEkUkvg10090 intact-crc:D37DF31C130BA576|rigid:/cm3hgULSL+FInLgjMhZjfE47KI false glutathione s tranferase tag:?-?(MINT-7212649)|binding-associated region:81-139(MINT-7212655) - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O88703 uniprotkb:P00523 intact:EBI-771231|uniprotkb:O70506|ensembl:ENSMUSP00000020581|ensembl:ENSMUSP00000097113 intact:EBI-848039|uniprotkb:Q90992|uniprotkb:Q90993|uniprotkb:Q91343|uniprotkb:Q91345|uniprotkb:Q92013|uniprotkb:Q98915|ensembl:ENSGALP00000049896|ensembl:ENSGALP00000054990|ensembl:ENSGALP00000068298 psi-mi:hcn2_mouse(display_long)|uniprotkb:Brain cyclic nucleotide-gated channel 2(gene name synonym)|uniprotkb:Hyperpolarization-activated cation channel 1(gene name synonym)|uniprotkb:Bcng2(gene name synonym)|uniprotkb:Hac1(gene name synonym)|uniprotkb:Hcn2(gene name)|psi-mi:Hcn2(display_short) psi-mi:src_chick(display_long)|uniprotkb:SRC(gene name)|psi-mi:SRC(display_short)|uniprotkb:pp60c-src(gene name synonym)|uniprotkb:Proto-oncogene c-Src(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Zong et al. (2005) pubmed:16079136|mint:MINT-7208279|doi:10.1074/jbc.M506544200 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7730009|mint:MINT-7212659 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_032252.1|dip:DIP-29326N|ensembl:ENSMUSG00000020331(gene)|ensembl:ENSMUST00000020581(transcript)|ensembl:ENSMUST00000099513(transcript)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030552"(cAMP binding)|go:"GO:0032590"(dendrite membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|mint:O88703|rcsb pdb:1Q3E|rcsb pdb:1Q43|rcsb pdb:1Q5O|rcsb pdb:2Q0A|rcsb pdb:3BPZ|rcsb pdb:3ETQ|rcsb pdb:3FFQ|rcsb pdb:4EQF|rcsb pdb:5JON|rcsb pdb:5KHG|rcsb pdb:5KHH|rcsb pdb:5KHI|rcsb pdb:5KHJ|rcsb pdb:5KHK|reactome:R-MMU-1296061|mint:MINT-7212668(identity) refseq:NP_990788.2|dip:DIP-449N|refseq:XP_015151834.1|ensembl:ENSGALG00000003855(gene)|ensembl:ENSGALT00000061823(transcript)|ensembl:ENSGALT00000070498(transcript)|ensembl:ENSGALT00000093274(transcript)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0020037"(heme binding)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036035"(osteoclast development)|go:"GO:0045087"(innate immune response)|go:"GO:0045453"(bone resorption)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071253"(connexin binding)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036028|interpro:IPR036860|mint:P00523|rcsb pdb:1F1W|rcsb pdb:1F2F|rcsb pdb:1NLO|rcsb pdb:1NLP|rcsb pdb:1P13|rcsb pdb:1PRL|rcsb pdb:1PRM|rcsb pdb:1RLP|rcsb pdb:1RLQ|rcsb pdb:1SRL|rcsb pdb:1SRM|rcsb pdb:2HWO|rcsb pdb:2HWP|rcsb pdb:2OIQ|rcsb pdb:2PTK|rcsb pdb:2QI8|rcsb pdb:2QLQ|rcsb pdb:2QQ7|rcsb pdb:3D7T|rcsb pdb:3D7U|rcsb pdb:3DQW|rcsb pdb:3DQX|rcsb pdb:3EL7|rcsb pdb:3EL8|rcsb pdb:3EN4|rcsb pdb:3EN5|rcsb pdb:3EN6|rcsb pdb:3EN7|rcsb pdb:3F3T|rcsb pdb:3F3U|rcsb pdb:3F3V|rcsb pdb:3F3W|rcsb pdb:3F6X|rcsb pdb:3FJ5|rcsb pdb:3G5D|rcsb pdb:3G6G|rcsb pdb:3G6H|rcsb pdb:3GEQ|rcsb pdb:3LOK|rcsb pdb:3OEZ|rcsb pdb:3OF0|rcsb pdb:3QLF|rcsb pdb:3QLG|rcsb pdb:3SVV|rcsb pdb:3TZ7|rcsb pdb:3TZ8|rcsb pdb:3TZ9|rcsb pdb:3U4W|rcsb pdb:3U51|rcsb pdb:3UQF|rcsb pdb:3UQG|rcsb pdb:4AGW|rcsb pdb:4DGG|rcsb pdb:4FIC|rcsb pdb:4HVU|rcsb pdb:4HVV|rcsb pdb:4HVW|rcsb pdb:4JZ3|rcsb pdb:4JZ4|rcsb pdb:4LE9|rcsb pdb:4LGG|rcsb pdb:4LGH|rcsb pdb:4MCV|rcsb pdb:4O2P|rcsb pdb:4OML|rcsb pdb:4OMM|rcsb pdb:4OMN|rcsb pdb:4OMO|rcsb pdb:4OMP|rcsb pdb:4OMQ|rcsb pdb:4QT7|rcsb pdb:4RTU|rcsb pdb:4RTV|rcsb pdb:4RTW|rcsb pdb:4RTX|rcsb pdb:4RTY|rcsb pdb:4RTZ|rcsb pdb:4U5J|rcsb pdb:4YBJ|rcsb pdb:4YBK|rcsb pdb:5BMM|rcsb pdb:5D10|rcsb pdb:5D11|rcsb pdb:5D12|rcsb pdb:5EC7|rcsb pdb:5ECA|rcsb pdb:5I11|rcsb pdb:5J5S|rcsb pdb:5K9I|rcsb pdb:5OAV|rcsb pdb:5OB0|rcsb pdb:5OB1|rcsb pdb:5OB2|rcsb pdb:5SWH|rcsb pdb:5SYS|rcsb pdb:5T0P|rcsb pdb:5TEH|rcsb pdb:5XP5|rcsb pdb:5XP7|rcsb pdb:6HVE|rcsb pdb:6HVF|rcsb pdb:6L8L|rcsb pdb:6WIW|rcsb pdb:6XVM|rcsb pdb:6XVN|rcsb pdb:6XVO|rcsb pdb:6XX2|rcsb pdb:6XX3|rcsb pdb:6XX4|rcsb pdb:6XX5|reactome:R-GGA-1227986|reactome:R-GGA-1251985|reactome:R-GGA-1253288|reactome:R-GGA-1257604|reactome:R-GGA-1433557|reactome:R-GGA-180292|reactome:R-GGA-186763|reactome:R-GGA-191650|reactome:R-GGA-2029481|reactome:R-GGA-210990|reactome:R-GGA-354192|reactome:R-GGA-354194|reactome:R-GGA-372708|reactome:R-GGA-389356|reactome:R-GGA-389513|reactome:R-GGA-3928662|reactome:R-GGA-3928663|reactome:R-GGA-3928664|reactome:R-GGA-3928665|reactome:R-GGA-418592|reactome:R-GGA-418594|reactome:R-GGA-418885|reactome:R-GGA-430116|reactome:R-GGA-437239|reactome:R-GGA-4420097|reactome:R-GGA-456926|reactome:R-GGA-5218921|reactome:R-GGA-5674135|reactome:R-GGA-6811558|reactome:R-GGA-8853659|reactome:R-GGA-8874081|reactome:R-GGA-8941858|reactome:R-GGA-9009391|mint:MINT-7212661(identity) - - - figure legend:f3b|comment:homomint|comment:mint|curation depth:mimix curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2009/06/25 2014/10/16 rogid:+2OZtagUBYgKm6J6eqLZzEkUkvg10090 rogid:4zMmRUOi44prLCXBJNuTuFIMkr49031 intact-crc:0D4AB55FF7CA08D2|rigid:/cm3hgULSL+FInLgjMhZjfE47KI false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)