#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P05067-4	uniprotkb:O43736	intact:EBI-302641|ensembl:ENSP00000345463|intact:EBI-8513344|intact:MINT-150885|intact:EBI-8513450|intact:EBI-8513789|intact:EBI-7458081|intact:EBI-7458225|intact:EBI-8513738|intact:EBI-8513677|intact:EBI-8513407|intact:EBI-7457926	intact:EBI-2431769|uniprotkb:Q6IBC9|uniprotkb:B2R7X5|uniprotkb:B4E062|ensembl:ENSP00000362395	psi-mi:p05067-4(display_long)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:PreA4 695(isoform synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:itm2a_human(display_long)|uniprotkb:ITM2A(gene name)|psi-mi:ITM2A(display_short)|uniprotkb:UNQ603/PRO1189(orf name)|uniprotkb:Protein E25(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Matsuda et al. (2005)	pubmed:15983050|imex:IM-19592	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2431777|imex:IM-19592-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-77613(a4_human)|ensembl:ENSG00000142192(gene)|ensembl:ENST00000348990(transcript)	refseq:NP_001165052.1|refseq:NP_004858.1|ensembl:ENSG00000078596(gene)|ensembl:ENST00000373298(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002317"(plasma cell differentiation)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|interpro:IPR007084(BRICHOS)|interpro:IPR040145	-	isoform-comment:A major isoform.	-	figure legend:Fig 1E|antibodies:"APP mouse monoclonal antibody 22C11 (Chemicon) was used to pull down APP interactions."|comment:A 17kDa proteolytic N terminal fragment also binds APP.|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2009/09/01	2014/10/16	rogid:g3lIuSzu8RGEONgITBEVFyMpfqk9606	rogid:MUY3ttm5dEkhKPnJZQlzfy9aQpg9606	intact-crc:E00E6B783B99A4A8|rigid:Dm7lf6UhcnRiII4BaUp9hUD1rcw	false	-	flag tag:n-n|sufficient binding region:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O43736	uniprotkb:P05067-4	intact:EBI-2431769|uniprotkb:Q6IBC9|uniprotkb:B2R7X5|uniprotkb:B4E062|ensembl:ENSP00000362395	intact:EBI-302641|ensembl:ENSP00000345463|intact:EBI-8513344|intact:MINT-150885|intact:EBI-8513450|intact:EBI-8513789|intact:EBI-7458081|intact:EBI-7458225|intact:EBI-8513738|intact:EBI-8513677|intact:EBI-8513407|intact:EBI-7457926	psi-mi:itm2a_human(display_long)|uniprotkb:ITM2A(gene name)|psi-mi:ITM2A(display_short)|uniprotkb:UNQ603/PRO1189(orf name)|uniprotkb:Protein E25(gene name synonym)	psi-mi:p05067-4(display_long)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:PreA4 695(isoform synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Matsuda et al. (2005)	pubmed:15983050|imex:IM-19592	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2432004|imex:IM-19592-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001165052.1|refseq:NP_004858.1|ensembl:ENSG00000078596(gene)|ensembl:ENST00000373298(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002317"(plasma cell differentiation)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|interpro:IPR007084(BRICHOS)|interpro:IPR040145	intact:EBI-77613(a4_human)|ensembl:ENSG00000142192(gene)|ensembl:ENST00000348990(transcript)	-	-	isoform-comment:A major isoform.	figure legend:Fig. 2b|comment:C83 isofirm did not precipate with ITM2A.|antibodies:EN3 anti ITM2A rabbit polyclonal antibody raised against aa 222-232 of human sequence used to immunoprecipate ITM2A complexes.|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-brain)|taxid:9606(Homo sapiens brain)	-	2009/09/01	2014/10/16	rogid:MUY3ttm5dEkhKPnJZQlzfy9aQpg9606	rogid:g3lIuSzu8RGEONgITBEVFyMpfqk9606	intact-crc:E7B19F4EA21B06AB|rigid:Dm7lf6UhcnRiII4BaUp9hUD1rcw	false	-	sufficient binding region:598-613	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O43736	uniprotkb:P05067-4	intact:EBI-2431769|uniprotkb:Q6IBC9|uniprotkb:B2R7X5|uniprotkb:B4E062|ensembl:ENSP00000362395	intact:EBI-302641|ensembl:ENSP00000345463|intact:EBI-8513344|intact:MINT-150885|intact:EBI-8513450|intact:EBI-8513789|intact:EBI-7458081|intact:EBI-7458225|intact:EBI-8513738|intact:EBI-8513677|intact:EBI-8513407|intact:EBI-7457926	psi-mi:itm2a_human(display_long)|uniprotkb:ITM2A(gene name)|psi-mi:ITM2A(display_short)|uniprotkb:UNQ603/PRO1189(orf name)|uniprotkb:Protein E25(gene name synonym)	psi-mi:p05067-4(display_long)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:PreA4 695(isoform synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Matsuda et al. (2005)	pubmed:15983050|imex:IM-19592	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2432863|imex:IM-19592-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001165052.1|refseq:NP_004858.1|ensembl:ENSG00000078596(gene)|ensembl:ENST00000373298(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002317"(plasma cell differentiation)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|interpro:IPR007084(BRICHOS)|interpro:IPR040145	intact:EBI-77613(a4_human)|ensembl:ENSG00000142192(gene)|ensembl:ENST00000348990(transcript)	-	-	isoform-comment:A major isoform.	figure legend:Figs. 1b-d|comment:The C83 isoform of APP was not found to bind to ITM2A|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2009/09/01	2014/10/16	rogid:MUY3ttm5dEkhKPnJZQlzfy9aQpg9606	rogid:g3lIuSzu8RGEONgITBEVFyMpfqk9606	intact-crc:3ABF30CFCA7084ED|rigid:Dm7lf6UhcnRiII4BaUp9hUD1rcw	false	sufficient binding region:1-131|flag tag:n-n	necessary binding region:598-613|glycosylated residue:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)