#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q155P7	uniprotkb:Q9CZA6	intact:EBI-2211248	intact:EBI-309934|uniprotkb:Q3UBS6|uniprotkb:Q3UIC1|uniprotkb:Q9ERR0|ensembl:ENSMUSP00000023359	psi-mi:q155p7_mouse(display_long)|uniprotkb:Cenpf(gene name)|psi-mi:Cenpf(display_short)|uniprotkb:Lek1(gene name synonym)	psi-mi:nde1_mouse(display_long)|uniprotkb:Nde1(gene name)|psi-mi:Nde1(display_short)|uniprotkb:Nude(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Soukoulis et al. (2005)	pubmed:15939891|imex:IM-20267	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2271715|imex:IM-20267-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR019513|interpro:IPR018463|interpro:IPR018302|interpro:IPR043513|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0000940"(outer kinetochore)|go:"GO:0001822"(kidney development)|go:"GO:0002724"(regulation of T cell cytokine production)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005930"(axoneme)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007507"(heart development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015031"(protein transport)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0016363"(nuclear matrix)|go:"GO:0021591"(ventricular system development)|go:"GO:0030496"(midbody)|go:"GO:0030885"(regulation of myeloid dendritic cell activation)|go:"GO:0032386"(regulation of intracellular transport)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045120"(pronucleus)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048866"(stem cell fate specification)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0055037"(recycling endosome)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0070840"(dynein complex binding)|go:"GO:0097539"(ciliary transition fiber)	refseq:NP_001107557.1|refseq:NP_075806.2|refseq:NP_001272432.1|refseq:NP_001272433.1|refseq:XP_011244302.1|ensembl:ENSMUSG00000022678(gene)|ensembl:ENSMUST00000023359(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000776"(kinetochore)|go:"GO:0001764"(neuron migration)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005819"(spindle)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0008017"(microtubule binding)|go:"GO:0016477"(cell migration)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030900"(forebrain development)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032154"(cleavage furrow)|go:"GO:0042802"(identical protein binding)|go:"GO:0045202"(synapse)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051301"(cell division)|go:"GO:0051303"(establishment of chromosome localization)|go:"GO:0051642"(centrosome localization)|go:"GO:2000574"(obsolete regulation of microtubule motor activity)|interpro:IPR006964(NUDE protein, C-terminal)|interpro:IPR033494|mint:Q9CZA6|reactome:R-MMU-141444|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5663220|reactome:R-MMU-68877|reactome:R-MMU-8854518|reactome:R-MMU-9648025|dip:DIP-54638N	-	-	-	figure legend:Fig 2A.|comment:cytLEK1 interacts with NDE1.|caution:"The species of origin of cytLEK1 is assumed to be mouse since in the introduction the authors \"Our laboratory has studied the structure, expression, and function of LEK1, a relatively large murine protein (>300 kDa) highly related to CMF1 (chicken) and CENP-F/mitosin (human) (16, 17).\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/03/11	2014/10/16	rogid:b3rPf5eE6WotbUeJcEwHdYF9Gwg10090	rogid:711HNgfdXkDQEAEhRwa4DjKah5s10090	intact-crc:FCEF00FB6C3C1EDA|rigid:TdOH42/RJVjdyXvrtRz2IoWUuQg	false	necessary binding region:2071-2149	-	-	-	psi-mi:"MI:0823"(predetermined feature)	psi-mi:"MI:0823"(predetermined feature)
uniprotkb:Q9CZA6	uniprotkb:Q155P7	intact:EBI-309934|uniprotkb:Q3UBS6|uniprotkb:Q3UIC1|uniprotkb:Q9ERR0|ensembl:ENSMUSP00000023359	intact:EBI-2211248	psi-mi:nde1_mouse(display_long)|uniprotkb:Nde1(gene name)|psi-mi:Nde1(display_short)|uniprotkb:Nude(gene name synonym)	psi-mi:q155p7_mouse(display_long)|uniprotkb:Cenpf(gene name)|psi-mi:Cenpf(display_short)|uniprotkb:Lek1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Soukoulis et al. (2005)	pubmed:15939891|imex:IM-20267	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2271733|imex:IM-20267-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107557.1|refseq:NP_075806.2|refseq:NP_001272432.1|refseq:NP_001272433.1|refseq:XP_011244302.1|ensembl:ENSMUSG00000022678(gene)|ensembl:ENSMUST00000023359(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000776"(kinetochore)|go:"GO:0001764"(neuron migration)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005819"(spindle)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0008017"(microtubule binding)|go:"GO:0016477"(cell migration)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030900"(forebrain development)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032154"(cleavage furrow)|go:"GO:0042802"(identical protein binding)|go:"GO:0045202"(synapse)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051301"(cell division)|go:"GO:0051303"(establishment of chromosome localization)|go:"GO:0051642"(centrosome localization)|go:"GO:2000574"(obsolete regulation of microtubule motor activity)|interpro:IPR006964(NUDE protein, C-terminal)|interpro:IPR033494|mint:Q9CZA6|reactome:R-MMU-141444|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5663220|reactome:R-MMU-68877|reactome:R-MMU-8854518|reactome:R-MMU-9648025|dip:DIP-54638N	interpro:IPR019513|interpro:IPR018463|interpro:IPR018302|interpro:IPR043513|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0000940"(outer kinetochore)|go:"GO:0001822"(kidney development)|go:"GO:0002724"(regulation of T cell cytokine production)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005930"(axoneme)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007507"(heart development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015031"(protein transport)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0016363"(nuclear matrix)|go:"GO:0021591"(ventricular system development)|go:"GO:0030496"(midbody)|go:"GO:0030885"(regulation of myeloid dendritic cell activation)|go:"GO:0032386"(regulation of intracellular transport)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045120"(pronucleus)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048866"(stem cell fate specification)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0055037"(recycling endosome)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0070840"(dynein complex binding)|go:"GO:0097539"(ciliary transition fiber)	-	-	-	figure legend:Fig 2A.|comment:cytLEK1 interacts with NDE1.|caution:"The species of origin of cytLEK1 is assumed to be mouse since in the introduction the authors \"Our laboratory has studied the structure, expression, and function of LEK1, a relatively large murine protein (>300 kDa) highly related to CMF1 (chicken) and CENP-F/mitosin (human) (16, 17).\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/03/11	2014/10/16	rogid:711HNgfdXkDQEAEhRwa4DjKah5s10090	rogid:b3rPf5eE6WotbUeJcEwHdYF9Gwg10090	intact-crc:5CB797348DC2920B|rigid:TdOH42/RJVjdyXvrtRz2IoWUuQg	false	necessary binding region:167-290	sufficient binding region:1906-2149	-	-	psi-mi:"MI:0823"(predetermined feature)	psi-mi:"MI:0823"(predetermined feature)
uniprotkb:Q9CZA6	uniprotkb:Q155P7	intact:EBI-309934|uniprotkb:Q3UBS6|uniprotkb:Q3UIC1|uniprotkb:Q9ERR0|ensembl:ENSMUSP00000023359	intact:EBI-2211248	psi-mi:nde1_mouse(display_long)|uniprotkb:Nde1(gene name)|psi-mi:Nde1(display_short)|uniprotkb:Nude(gene name synonym)	psi-mi:q155p7_mouse(display_long)|uniprotkb:Cenpf(gene name)|psi-mi:Cenpf(display_short)|uniprotkb:Lek1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Soukoulis et al. (2005)	pubmed:15939891|imex:IM-20267	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2271756|imex:IM-20267-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107557.1|refseq:NP_075806.2|refseq:NP_001272432.1|refseq:NP_001272433.1|refseq:XP_011244302.1|ensembl:ENSMUSG00000022678(gene)|ensembl:ENSMUST00000023359(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000776"(kinetochore)|go:"GO:0001764"(neuron migration)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005819"(spindle)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0008017"(microtubule binding)|go:"GO:0016477"(cell migration)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030900"(forebrain development)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032154"(cleavage furrow)|go:"GO:0042802"(identical protein binding)|go:"GO:0045202"(synapse)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051301"(cell division)|go:"GO:0051303"(establishment of chromosome localization)|go:"GO:0051642"(centrosome localization)|go:"GO:2000574"(obsolete regulation of microtubule motor activity)|interpro:IPR006964(NUDE protein, C-terminal)|interpro:IPR033494|mint:Q9CZA6|reactome:R-MMU-141444|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5663220|reactome:R-MMU-68877|reactome:R-MMU-8854518|reactome:R-MMU-9648025|dip:DIP-54638N	interpro:IPR019513|interpro:IPR018463|interpro:IPR018302|interpro:IPR043513|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0000940"(outer kinetochore)|go:"GO:0001822"(kidney development)|go:"GO:0002724"(regulation of T cell cytokine production)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005930"(axoneme)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007507"(heart development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015031"(protein transport)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0016363"(nuclear matrix)|go:"GO:0021591"(ventricular system development)|go:"GO:0030496"(midbody)|go:"GO:0030885"(regulation of myeloid dendritic cell activation)|go:"GO:0032386"(regulation of intracellular transport)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045120"(pronucleus)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048866"(stem cell fate specification)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0055037"(recycling endosome)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0070840"(dynein complex binding)|go:"GO:0097539"(ciliary transition fiber)	-	-	-	figure legend:Fig 2B and 2C.|comment:The C domain of cytLEK1 is required for interaction with NDE1.|caution:"The species of origin of cytLEK1 is assumed to be mouse since in the introduction the authors \"Our laboratory has studied the structure, expression, and function of LEK1, a relatively large murine protein (>300 kDa) highly related to CMF1 (chicken) and CENP-F/mitosin (human) (16, 17).\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2009/03/11	2014/10/16	rogid:711HNgfdXkDQEAEhRwa4DjKah5s10090	rogid:b3rPf5eE6WotbUeJcEwHdYF9Gwg10090	intact-crc:E35B1586F6365BD0|rigid:TdOH42/RJVjdyXvrtRz2IoWUuQg	false	green fluorescent protein tag:?-?	sufficient binding region:1906-2149|myc tag:?-?|necessary binding region:2071-2149	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9CZA6	uniprotkb:Q155P7	intact:EBI-309934|uniprotkb:Q3UBS6|uniprotkb:Q3UIC1|uniprotkb:Q9ERR0|ensembl:ENSMUSP00000023359	intact:EBI-2211248	psi-mi:nde1_mouse(display_long)|uniprotkb:Nde1(gene name)|psi-mi:Nde1(display_short)|uniprotkb:Nude(gene name synonym)	psi-mi:q155p7_mouse(display_long)|uniprotkb:Cenpf(gene name)|psi-mi:Cenpf(display_short)|uniprotkb:Lek1(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Soukoulis et al. (2005)	pubmed:15939891|imex:IM-20267	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2271894|imex:IM-20267-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107557.1|refseq:NP_075806.2|refseq:NP_001272432.1|refseq:NP_001272433.1|refseq:XP_011244302.1|ensembl:ENSMUSG00000022678(gene)|ensembl:ENSMUST00000023359(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000776"(kinetochore)|go:"GO:0001764"(neuron migration)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005819"(spindle)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0008017"(microtubule binding)|go:"GO:0016477"(cell migration)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030900"(forebrain development)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032154"(cleavage furrow)|go:"GO:0042802"(identical protein binding)|go:"GO:0045202"(synapse)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051301"(cell division)|go:"GO:0051303"(establishment of chromosome localization)|go:"GO:0051642"(centrosome localization)|go:"GO:2000574"(obsolete regulation of microtubule motor activity)|interpro:IPR006964(NUDE protein, C-terminal)|interpro:IPR033494|mint:Q9CZA6|reactome:R-MMU-141444|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5663220|reactome:R-MMU-68877|reactome:R-MMU-8854518|reactome:R-MMU-9648025|dip:DIP-54638N	interpro:IPR019513|interpro:IPR018463|interpro:IPR018302|interpro:IPR043513|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0000940"(outer kinetochore)|go:"GO:0001822"(kidney development)|go:"GO:0002724"(regulation of T cell cytokine production)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005930"(axoneme)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007507"(heart development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015031"(protein transport)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0016363"(nuclear matrix)|go:"GO:0021591"(ventricular system development)|go:"GO:0030496"(midbody)|go:"GO:0030885"(regulation of myeloid dendritic cell activation)|go:"GO:0032386"(regulation of intracellular transport)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045120"(pronucleus)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048866"(stem cell fate specification)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0055037"(recycling endosome)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0070840"(dynein complex binding)|go:"GO:0097539"(ciliary transition fiber)	go:"GO:0048471"(perinuclear region of cytoplasm)	-	-	figure legend:Fig 3C and 3D.|comment:cytLEK1 colocalizes with NDE1 at the perinuclear region of the cytoplasm.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-3t3)|taxid:10090(Mus musculus embryo cells)	-	2009/03/11	2014/10/16	rogid:711HNgfdXkDQEAEhRwa4DjKah5s10090	rogid:b3rPf5eE6WotbUeJcEwHdYF9Gwg10090	intact-crc:F8D6B4C9C8015E3E|rigid:TdOH42/RJVjdyXvrtRz2IoWUuQg	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P63005	uniprotkb:Q155P7	intact:EBI-917499|uniprotkb:O35592|uniprotkb:P43035|uniprotkb:P81692|uniprotkb:Q9R2A6|ensembl:ENSMUSP00000021091|ensembl:ENSMUSP00000099578	intact:EBI-2211248	psi-mi:lis1_mouse(display_long)|uniprotkb:PAF acetylhydrolase 45 kDa subunit(gene name synonym)|uniprotkb:PAF-AH alpha(gene name synonym)|uniprotkb:Lissencephaly-1 protein(gene name synonym)|uniprotkb:Pafah1b1(gene name)|psi-mi:Pafah1b1(display_short)|uniprotkb:Lis1(gene name synonym)|uniprotkb:Lis-1(gene name synonym)|uniprotkb:Pafaha(gene name synonym)	psi-mi:q155p7_mouse(display_long)|uniprotkb:Cenpf(gene name)|psi-mi:Cenpf(display_short)|uniprotkb:Lek1(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Soukoulis et al. (2005)	pubmed:15939891|imex:IM-20267	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2272212|imex:IM-20267-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_038653.1|dip:DIP-29555N|ensembl:ENSMUSG00000020745(gene)|ensembl:ENSMUST00000021091(transcript)|ensembl:ENSMUST00000102520(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000235"(astral microtubule)|go:"GO:0000776"(kinetochore)|go:"GO:0001667"(ameboidal-type cell migration)|go:"GO:0001675"(acrosome assembly)|go:"GO:0001764"(neuron migration)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005938"(cell cortex)|go:"GO:0007017"(microtubule-based process)|go:"GO:0007097"(nuclear migration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007281"(germ cell development)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007611"(learning or memory)|go:"GO:0008017"(microtubule binding)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0008247"(1-alkyl-2-acetylglycerophosphocholine esterase complex)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009306"(protein secretion)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016477"(cell migration)|go:"GO:0017145"(stem cell division)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0021540"(corpus callosum morphogenesis)|go:"GO:0021766"(hippocampus development)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0021895"(cerebral cortex neuron differentiation)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0031514"(motile cilium)|go:"GO:0031965"(nuclear membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032420"(stereocilium)|go:"GO:0036035"(osteoclast development)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0042249"(establishment of planar polarity of embryonic epithelium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051012"(microtubule sliding)|go:"GO:0051081"(nuclear membrane disassembly)|go:"GO:0051130"(positive regulation of cellular component organization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0051661"(maintenance of centrosome location)|go:"GO:0060117"(auditory receptor cell development)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090102"(cochlea development)|go:"GO:0090176"(microtubule cytoskeleton organization involved in establishment of planar polarity)|go:"GO:0090724"(central region of growth cone)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000574"(obsolete regulation of microtubule motor activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR017252(Dynein regulator)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR037190|mint:P63005|rcsb pdb:1UUJ|rcsb pdb:1VYH|reactome:R-MMU-141444|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5663220|reactome:R-MMU-6811436|reactome:R-MMU-68877|reactome:R-MMU-8854518|reactome:R-MMU-9648025	interpro:IPR019513|interpro:IPR018463|interpro:IPR018302|interpro:IPR043513|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0000940"(outer kinetochore)|go:"GO:0001822"(kidney development)|go:"GO:0002724"(regulation of T cell cytokine production)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005930"(axoneme)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007507"(heart development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015031"(protein transport)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0016363"(nuclear matrix)|go:"GO:0021591"(ventricular system development)|go:"GO:0030496"(midbody)|go:"GO:0030885"(regulation of myeloid dendritic cell activation)|go:"GO:0032386"(regulation of intracellular transport)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045120"(pronucleus)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048866"(stem cell fate specification)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0055037"(recycling endosome)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0070840"(dynein complex binding)|go:"GO:0097539"(ciliary transition fiber)	go:"GO:0048471"(perinuclear region of cytoplasm)	-	-	figure legend:Fig 3B.|comment:The cytLEK1 interacts with LIS1.|caution:"The species of origin of cytLEK1 is assumed to be mouse since in the introduction the authors \"Our laboratory has studied the structure, expression, and function of LEK1, a relatively large murine protein (>300 kDa) highly related to CMF1 (chicken) and CENP-F/mitosin (human) (16, 17).\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-3t3)|taxid:10090(Mus musculus embryo cells)	-	2009/03/11	2014/10/16	rogid:worzim1DpTldfv3SQdodqPmMozk10090	rogid:b3rPf5eE6WotbUeJcEwHdYF9Gwg10090	intact-crc:5EEC40BA41C64348|rigid:uRbZSlCLikzsBpyb46nBr/NExB8	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q9CZA6	uniprotkb:Q155P7	intact:EBI-309934|uniprotkb:Q3UBS6|uniprotkb:Q3UIC1|uniprotkb:Q9ERR0|ensembl:ENSMUSP00000023359	intact:EBI-2211248	psi-mi:nde1_mouse(display_long)|uniprotkb:Nde1(gene name)|psi-mi:Nde1(display_short)|uniprotkb:Nude(gene name synonym)	psi-mi:q155p7_mouse(display_long)|uniprotkb:Cenpf(gene name)|psi-mi:Cenpf(display_short)|uniprotkb:Lek1(gene name synonym)	psi-mi:"MI:0051"(fluorescence technology)	Soukoulis et al. (2005)	pubmed:15939891|imex:IM-20267	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2272296|imex:IM-20267-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107557.1|refseq:NP_075806.2|refseq:NP_001272432.1|refseq:NP_001272433.1|refseq:XP_011244302.1|ensembl:ENSMUSG00000022678(gene)|ensembl:ENSMUST00000023359(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000776"(kinetochore)|go:"GO:0001764"(neuron migration)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005819"(spindle)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0008017"(microtubule binding)|go:"GO:0016477"(cell migration)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030900"(forebrain development)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032154"(cleavage furrow)|go:"GO:0042802"(identical protein binding)|go:"GO:0045202"(synapse)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051301"(cell division)|go:"GO:0051303"(establishment of chromosome localization)|go:"GO:0051642"(centrosome localization)|go:"GO:2000574"(obsolete regulation of microtubule motor activity)|interpro:IPR006964(NUDE protein, C-terminal)|interpro:IPR033494|mint:Q9CZA6|reactome:R-MMU-141444|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5663220|reactome:R-MMU-68877|reactome:R-MMU-8854518|reactome:R-MMU-9648025|dip:DIP-54638N	interpro:IPR019513|interpro:IPR018463|interpro:IPR018302|interpro:IPR043513|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0000940"(outer kinetochore)|go:"GO:0001822"(kidney development)|go:"GO:0002724"(regulation of T cell cytokine production)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005930"(axoneme)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007507"(heart development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015031"(protein transport)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0016363"(nuclear matrix)|go:"GO:0021591"(ventricular system development)|go:"GO:0030496"(midbody)|go:"GO:0030885"(regulation of myeloid dendritic cell activation)|go:"GO:0032386"(regulation of intracellular transport)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045120"(pronucleus)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048866"(stem cell fate specification)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0055037"(recycling endosome)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0070840"(dynein complex binding)|go:"GO:0097539"(ciliary transition fiber)	go:"GO:0005813"(centrosome)	-	-	figure legend:Fig 4A.|comment:The C-domain colocalizes with NudE in COS-7 cells. Expression of the C domain alone directs this colocalization at the centrosome in COS-7 cells.|caution:"The species of origin of cytLEK1 is assumed to be mouse since in the introduction the authors \"Our laboratory has studied the structure, expression, and function of LEK1, a relatively large murine protein (>300 kDa) highly related to CMF1 (chicken) and CENP-F/mitosin (human) (16, 17).\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2009/03/11	2014/10/16	rogid:711HNgfdXkDQEAEhRwa4DjKah5s10090	rogid:b3rPf5eE6WotbUeJcEwHdYF9Gwg10090	intact-crc:31D9071D5C42D492|rigid:TdOH42/RJVjdyXvrtRz2IoWUuQg	false	green fluorescent protein tag:?-?	necessary binding region:?-?|myc tag:?-?	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q155P7	intact:EBI-2272346	intact:EBI-2211248	-	psi-mi:q155p7_mouse(display_long)|uniprotkb:Cenpf(gene name)|psi-mi:Cenpf(display_short)|uniprotkb:Lek1(gene name synonym)	psi-mi:nde1_cerae_protein(display_short)|psi-mi:EBI-2272346(display_long)	psi-mi:"MI:0051"(fluorescence technology)	Soukoulis et al. (2005)	pubmed:15939891|imex:IM-20267	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2272334|imex:IM-20267-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR019513|interpro:IPR018463|interpro:IPR018302|interpro:IPR043513|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0000940"(outer kinetochore)|go:"GO:0001822"(kidney development)|go:"GO:0002724"(regulation of T cell cytokine production)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005930"(axoneme)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007507"(heart development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015031"(protein transport)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0016363"(nuclear matrix)|go:"GO:0021591"(ventricular system development)|go:"GO:0030496"(midbody)|go:"GO:0030885"(regulation of myeloid dendritic cell activation)|go:"GO:0032386"(regulation of intracellular transport)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045120"(pronucleus)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048866"(stem cell fate specification)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0055037"(recycling endosome)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0070840"(dynein complex binding)|go:"GO:0097539"(ciliary transition fiber)	-	go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0005813"(centrosome)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:"similar to NDE1_HUMAN (AC: Q9NXR1)."	figure legend:Fig 4C.|comment:The C domain also colocalizes with endogenous NudE.|caution:"The species of origin of cytLEK1 is assumed to be mouse since in the introduction the authors \"Our laboratory has studied the structure, expression, and function of LEK1, a relatively large murine protein (>300 kDa) highly related to CMF1 (chicken) and CENP-F/mitosin (human) (16, 17).\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2009/03/11	2014/10/16	rogid:b3rPf5eE6WotbUeJcEwHdYF9Gwg10090	-	intact-crc:E5DDE27E6430330F	false	necessary binding region:c-c|myc tag:?-?	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q155P7	intact:EBI-2272374	intact:EBI-2211248	-	psi-mi:q155p7_mouse(display_long)|uniprotkb:Cenpf(gene name)|psi-mi:Cenpf(display_short)|uniprotkb:Lek1(gene name synonym)	psi-mi:gamma_tubulin_cerae(display_short)|psi-mi:EBI-2272374(display_long)	psi-mi:"MI:0051"(fluorescence technology)	Soukoulis et al. (2005)	pubmed:15939891|imex:IM-20267	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2272376|imex:IM-20267-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR019513|interpro:IPR018463|interpro:IPR018302|interpro:IPR043513|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0000940"(outer kinetochore)|go:"GO:0001822"(kidney development)|go:"GO:0002724"(regulation of T cell cytokine production)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005930"(axoneme)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007507"(heart development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015031"(protein transport)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0016363"(nuclear matrix)|go:"GO:0021591"(ventricular system development)|go:"GO:0030496"(midbody)|go:"GO:0030885"(regulation of myeloid dendritic cell activation)|go:"GO:0032386"(regulation of intracellular transport)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045120"(pronucleus)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048866"(stem cell fate specification)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0055037"(recycling endosome)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0070840"(dynein complex binding)|go:"GO:0097539"(ciliary transition fiber)	-	go:"GO:0005813"(centrosome)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt	figure legend:Fig 4B.|comment:The C domain also colocalizes with endogenous gamma-tubulin.|caution:"The species of origin of cytLEK1 is assumed to be mouse since in the introduction the authors \"Our laboratory has studied the structure, expression, and function of LEK1, a relatively large murine protein (>300 kDa) highly related to CMF1 (chicken) and CENP-F/mitosin (human) (16, 17).\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2009/03/11	2014/10/16	rogid:b3rPf5eE6WotbUeJcEwHdYF9Gwg10090	-	intact-crc:D28D3DEED1C8D493	false	necessary binding region:c-c|myc tag:?-?	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q9CZA6	uniprotkb:Q155P7	intact:EBI-309934|uniprotkb:Q3UBS6|uniprotkb:Q3UIC1|uniprotkb:Q9ERR0|ensembl:ENSMUSP00000023359	intact:EBI-2211248	psi-mi:nde1_mouse(display_long)|uniprotkb:Nde1(gene name)|psi-mi:Nde1(display_short)|uniprotkb:Nude(gene name synonym)	psi-mi:q155p7_mouse(display_long)|uniprotkb:Cenpf(gene name)|psi-mi:Cenpf(display_short)|uniprotkb:Lek1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Soukoulis et al. (2005)	pubmed:15939891|imex:IM-20267	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2298821|imex:IM-20267-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107557.1|refseq:NP_075806.2|refseq:NP_001272432.1|refseq:NP_001272433.1|refseq:XP_011244302.1|ensembl:ENSMUSG00000022678(gene)|ensembl:ENSMUST00000023359(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000776"(kinetochore)|go:"GO:0001764"(neuron migration)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005819"(spindle)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0008017"(microtubule binding)|go:"GO:0016477"(cell migration)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030900"(forebrain development)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032154"(cleavage furrow)|go:"GO:0042802"(identical protein binding)|go:"GO:0045202"(synapse)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051301"(cell division)|go:"GO:0051303"(establishment of chromosome localization)|go:"GO:0051642"(centrosome localization)|go:"GO:2000574"(obsolete regulation of microtubule motor activity)|interpro:IPR006964(NUDE protein, C-terminal)|interpro:IPR033494|mint:Q9CZA6|reactome:R-MMU-141444|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5663220|reactome:R-MMU-68877|reactome:R-MMU-8854518|reactome:R-MMU-9648025|dip:DIP-54638N	interpro:IPR019513|interpro:IPR018463|interpro:IPR018302|interpro:IPR043513|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0000940"(outer kinetochore)|go:"GO:0001822"(kidney development)|go:"GO:0002724"(regulation of T cell cytokine production)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005930"(axoneme)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007507"(heart development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015031"(protein transport)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0016363"(nuclear matrix)|go:"GO:0021591"(ventricular system development)|go:"GO:0030496"(midbody)|go:"GO:0030885"(regulation of myeloid dendritic cell activation)|go:"GO:0032386"(regulation of intracellular transport)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045120"(pronucleus)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048866"(stem cell fate specification)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0055037"(recycling endosome)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0070840"(dynein complex binding)|go:"GO:0097539"(ciliary transition fiber)	-	-	-	figure legend:Fig 2A.|comment:cytLEK1 interacts with NDE1.|caution:"The species of origin of cytLEK1 is assumed to be mouse since in the introduction the authors \"Our laboratory has studied the structure, expression, and function of LEK1, a relatively large murine protein (>300 kDa) highly related to CMF1 (chicken) and CENP-F/mitosin (human) (16, 17).\""|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/03/11	2014/10/16	rogid:711HNgfdXkDQEAEhRwa4DjKah5s10090	rogid:b3rPf5eE6WotbUeJcEwHdYF9Gwg10090	intact-crc:DE22EFB6CA1534FF|rigid:TdOH42/RJVjdyXvrtRz2IoWUuQg	false	-	sufficient binding region:1906-2149|necessary binding region:2071-2149	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)