#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q15080 uniprotkb:P14598 intact:EBI-1036870|uniprotkb:O60808|uniprotkb:Q86U56|uniprotkb:Q9BU98|uniprotkb:Q9NP45|uniprotkb:A8K4F9|intact:EBI-28974814|ensembl:ENSP00000248899 intact:EBI-395044|uniprotkb:A6NEH2|uniprotkb:A8K7S9|uniprotkb:O43842|uniprotkb:Q2PP07|uniprotkb:Q9BU90|uniprotkb:Q9BXI7|uniprotkb:Q9BXI8|uniprotkb:Q9UDV9|uniprotkb:Q9UMU2|uniprotkb:Q53FR5|ensembl:ENSP00000289473 psi-mi:ncf4_human(display_long)|uniprotkb:NCF4(gene name)|psi-mi:NCF4(display_short)|uniprotkb:Neutrophil NADPH oxidase factor 4(gene name synonym)|uniprotkb:p40-phox(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 4(gene name synonym)|uniprotkb:SH3PXD4(gene name synonym) psi-mi:ncf1_human(display_long)|uniprotkb:NCF1(gene name)|psi-mi:NCF1(display_short)|uniprotkb:Neutrophil NADPH oxidase factor 1(gene name synonym)|uniprotkb:47 kDa neutrophil oxidase factor(gene name synonym)|uniprotkb:p47-phox(gene name synonym)|uniprotkb:NCF-47K(gene name synonym)|uniprotkb:47 kDa autosomal chronic granulomatous disease protein(gene name synonym)|uniprotkb:Nox-organizing protein 2(gene name synonym)|uniprotkb:Nox organizer 2(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 1A(gene name synonym)|uniprotkb:NOXO2(gene name synonym)|uniprotkb:SH3PXD1A(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Massenet et al. (2005) pubmed:15657040|mint:MINT-7219111|doi:10.1074/jbc.M412897200|imex:IM-28305 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7456914|mint:MINT-7300344|imex:IM-28305-1|wwpdb:1w70 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000622.2|refseq:NP_038202.2|ensembl:ENSP00000248899|ensembl:ENST00000397147|ensembl:ENSP00000380334|ensembl:ENSG00000100365(gene)|ensembl:ENST00000248899(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0032010"(phagolysosome)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0045730"(respiratory burst)|go:"GO:0060090"(molecular adaptor activity)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000919(Neutrophil cytosol factor P40)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR034853|interpro:IPR034912|interpro:IPR035541|interpro:IPR036028|interpro:IPR036871|mint:Q15080|rcsb pdb:1H6H|rcsb pdb:1OEY|rcsb pdb:1W6X|rcsb pdb:1W70|rcsb pdb:1Z9Q|rcsb pdb:2DYB|reactome:R-HSA-1222556|reactome:R-HSA-1236973|reactome:R-HSA-3299685|reactome:R-HSA-4420097|reactome:R-HSA-5668599|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|dip:DIP-17019N|mint:MINT-7300346(identity) go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006968"(cellular defense response)|go:"GO:0009055"(electron transfer activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016175"("superoxide-generating NAD(P)H oxidase activity")|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030425"(dendrite)|go:"GO:0032010"(phagolysosome)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045730"(respiratory burst)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060264"(regulation of respiratory burst involved in inflammatory response)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1903409"(reactive oxygen species biosynthetic process)|interpro:IPR001452(Src homology-3)|interpro:IPR001655(Neutrophil cytosol factor 1)|interpro:IPR001683(Phox-like)|interpro:IPR015039(NADPH oxidase subunit p47Phox, C terminal)|interpro:IPR032136|interpro:IPR034909|interpro:IPR035756|interpro:IPR035757|interpro:IPR036028|interpro:IPR036871|mint:P14598|rcsb pdb:1GD5|rcsb pdb:1K4U|rcsb pdb:1KQ6|rcsb pdb:1NG2|rcsb pdb:1O7K|rcsb pdb:1OV3|rcsb pdb:1UEC|rcsb pdb:1W70|rcsb pdb:1WLP|reactome:R-HSA-1222556|reactome:R-HSA-1236973|reactome:R-HSA-3299685|reactome:R-HSA-4420097|reactome:R-HSA-5668599|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|ensembl:ENSG00000158517(gene)|ensembl:ENST00000289473(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|refseq:NP_000256.4|dip:DIP-126N|mint:MINT-7300347(identity) - - - figure legend:t1 f2 f3a f3c f4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/11/17 2020/08/28 rogid:gQ1MnSPLdf7S4yHbXzXKGskLtBE9606 rogid:cNIwxrttmz096/m5mr+NRK5D9Nc9606 intact-crc:5EA9C4821476CAC4|rigid:U79iRpN3pEegcYwGADgFjzc22Xc false binding-associated region:169-228(MINT-7300356) binding-associated region:360-372(MINT-7300351) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P14598 uniprotkb:Q15080 intact:EBI-395044|uniprotkb:A6NEH2|uniprotkb:A8K7S9|uniprotkb:O43842|uniprotkb:Q2PP07|uniprotkb:Q9BU90|uniprotkb:Q9BXI7|uniprotkb:Q9BXI8|uniprotkb:Q9UDV9|uniprotkb:Q9UMU2|uniprotkb:Q53FR5|ensembl:ENSP00000289473 intact:EBI-1036870|uniprotkb:O60808|uniprotkb:Q86U56|uniprotkb:Q9BU98|uniprotkb:Q9NP45|uniprotkb:A8K4F9|intact:EBI-28974814|ensembl:ENSP00000248899 psi-mi:ncf1_human(display_long)|uniprotkb:NCF1(gene name)|psi-mi:NCF1(display_short)|uniprotkb:Neutrophil NADPH oxidase factor 1(gene name synonym)|uniprotkb:47 kDa neutrophil oxidase factor(gene name synonym)|uniprotkb:p47-phox(gene name synonym)|uniprotkb:NCF-47K(gene name synonym)|uniprotkb:47 kDa autosomal chronic granulomatous disease protein(gene name synonym)|uniprotkb:Nox-organizing protein 2(gene name synonym)|uniprotkb:Nox organizer 2(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 1A(gene name synonym)|uniprotkb:NOXO2(gene name synonym)|uniprotkb:SH3PXD1A(gene name synonym) psi-mi:ncf4_human(display_long)|uniprotkb:NCF4(gene name)|psi-mi:NCF4(display_short)|uniprotkb:Neutrophil NADPH oxidase factor 4(gene name synonym)|uniprotkb:p40-phox(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 4(gene name synonym)|uniprotkb:SH3PXD4(gene name synonym) psi-mi:"MI:0017"(classical fluorescence spectroscopy) Massenet et al. (2005) pubmed:15657040|mint:MINT-7219111|doi:10.1074/jbc.M412897200|imex:IM-28305 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7456961|mint:MINT-7300360|imex:IM-28305-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006968"(cellular defense response)|go:"GO:0009055"(electron transfer activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016175"("superoxide-generating NAD(P)H oxidase activity")|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030425"(dendrite)|go:"GO:0032010"(phagolysosome)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045730"(respiratory burst)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060264"(regulation of respiratory burst involved in inflammatory response)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1903409"(reactive oxygen species biosynthetic process)|interpro:IPR001452(Src homology-3)|interpro:IPR001655(Neutrophil cytosol factor 1)|interpro:IPR001683(Phox-like)|interpro:IPR015039(NADPH oxidase subunit p47Phox, C terminal)|interpro:IPR032136|interpro:IPR034909|interpro:IPR035756|interpro:IPR035757|interpro:IPR036028|interpro:IPR036871|mint:P14598|rcsb pdb:1GD5|rcsb pdb:1K4U|rcsb pdb:1KQ6|rcsb pdb:1NG2|rcsb pdb:1O7K|rcsb pdb:1OV3|rcsb pdb:1UEC|rcsb pdb:1W70|rcsb pdb:1WLP|reactome:R-HSA-1222556|reactome:R-HSA-1236973|reactome:R-HSA-3299685|reactome:R-HSA-4420097|reactome:R-HSA-5668599|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|ensembl:ENSG00000158517(gene)|ensembl:ENST00000289473(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|refseq:NP_000256.4|dip:DIP-126N|mint:MINT-7300362(identity) refseq:NP_000622.2|refseq:NP_038202.2|ensembl:ENSP00000248899|ensembl:ENST00000397147|ensembl:ENSP00000380334|ensembl:ENSG00000100365(gene)|ensembl:ENST00000248899(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0032010"(phagolysosome)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0045730"(respiratory burst)|go:"GO:0060090"(molecular adaptor activity)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000919(Neutrophil cytosol factor P40)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR034853|interpro:IPR034912|interpro:IPR035541|interpro:IPR036028|interpro:IPR036871|mint:Q15080|rcsb pdb:1H6H|rcsb pdb:1OEY|rcsb pdb:1W6X|rcsb pdb:1W70|rcsb pdb:1Z9Q|rcsb pdb:2DYB|reactome:R-HSA-1222556|reactome:R-HSA-1236973|reactome:R-HSA-3299685|reactome:R-HSA-4420097|reactome:R-HSA-5668599|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|dip:DIP-17019N|mint:MINT-7300367(identity) - - - figure legend:t2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/11/17 2020/08/28 rogid:cNIwxrttmz096/m5mr+NRK5D9Nc9606 rogid:gQ1MnSPLdf7S4yHbXzXKGskLtBE9606 intact-crc:C95139832BAFBE07|rigid:U79iRpN3pEegcYwGADgFjzc22Xc false binding-associated region:358-372(MINT-7300363) binding-associated region:169-228(MINT-7300368) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P19878 uniprotkb:P14598 intact:EBI-489611|uniprotkb:Q2PP06|uniprotkb:Q8NFC7|ensembl:ENSP00000356505|ensembl:ENSP00000356506|uniprotkb:Q9BV51|uniprotkb:B2R6Q1|uniprotkb:B4DKQ7|uniprotkb:B4DQA7|uniprotkb:E9PHJ2|uniprotkb:E9PHX3 intact:EBI-395044|uniprotkb:A6NEH2|uniprotkb:A8K7S9|uniprotkb:O43842|uniprotkb:Q2PP07|uniprotkb:Q9BU90|uniprotkb:Q9BXI7|uniprotkb:Q9BXI8|uniprotkb:Q9UDV9|uniprotkb:Q9UMU2|uniprotkb:Q53FR5|ensembl:ENSP00000289473 psi-mi:ncf2_human(display_long)|uniprotkb:NOXA2(gene name synonym)|uniprotkb:P67PHOX(gene name synonym)|uniprotkb:Neutrophil NADPH oxidase factor 2(gene name synonym)|uniprotkb:NADPH oxidase activator 2(gene name synonym)|uniprotkb:67 kDa neutrophil oxidase factor(gene name synonym)|uniprotkb:p67-phox(gene name synonym)|uniprotkb:NCF2(gene name)|psi-mi:NCF2(display_short) psi-mi:ncf1_human(display_long)|uniprotkb:NCF1(gene name)|psi-mi:NCF1(display_short)|uniprotkb:Neutrophil NADPH oxidase factor 1(gene name synonym)|uniprotkb:47 kDa neutrophil oxidase factor(gene name synonym)|uniprotkb:p47-phox(gene name synonym)|uniprotkb:NCF-47K(gene name synonym)|uniprotkb:47 kDa autosomal chronic granulomatous disease protein(gene name synonym)|uniprotkb:Nox-organizing protein 2(gene name synonym)|uniprotkb:Nox organizer 2(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 1A(gene name synonym)|uniprotkb:NOXO2(gene name synonym)|uniprotkb:SH3PXD1A(gene name synonym) psi-mi:"MI:0017"(classical fluorescence spectroscopy) Massenet et al. (2005) pubmed:15657040|mint:MINT-7219111|doi:10.1074/jbc.M412897200|imex:IM-28305 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7457005|mint:MINT-7300396|imex:IM-28305-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:2DMO|reactome:R-HSA-1222556|reactome:R-HSA-1236973|reactome:R-HSA-3299685|reactome:R-HSA-4420097|reactome:R-HSA-5668599|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|rcsb pdb:1WM5|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0045087"(innate immune response)|go:"GO:0045730"(respiratory burst)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001452(Src homology-3)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR034885|interpro:IPR034889|interpro:IPR035546|interpro:IPR036028|mint:P19878|rcsb pdb:1E96|rcsb pdb:1HH8|rcsb pdb:1K4U|rcsb pdb:1OEY|ensembl:ENSG00000116701(gene)|ensembl:ENST00000367535(transcript)|ensembl:ENST00000367536(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005829"(cytosol)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0006968"(cellular defense response)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009055"(electron transfer activity)|go:"GO:0016020"(membrane)|go:"GO:0016175"("superoxide-generating NAD(P)H oxidase activity")|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032010"(phagolysosome)|refseq:NP_000424.2|refseq:NP_001121123.1|refseq:NP_001177718.1|refseq:XP_011507882.1|refseq:XP_011507883.1|refseq:NP_001177723.1|dip:DIP-76N|mint:MINT-7300398(identity) go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006968"(cellular defense response)|go:"GO:0009055"(electron transfer activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016175"("superoxide-generating NAD(P)H oxidase activity")|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030425"(dendrite)|go:"GO:0032010"(phagolysosome)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045730"(respiratory burst)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060264"(regulation of respiratory burst involved in inflammatory response)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1903409"(reactive oxygen species biosynthetic process)|interpro:IPR001452(Src homology-3)|interpro:IPR001655(Neutrophil cytosol factor 1)|interpro:IPR001683(Phox-like)|interpro:IPR015039(NADPH oxidase subunit p47Phox, C terminal)|interpro:IPR032136|interpro:IPR034909|interpro:IPR035756|interpro:IPR035757|interpro:IPR036028|interpro:IPR036871|mint:P14598|rcsb pdb:1GD5|rcsb pdb:1K4U|rcsb pdb:1KQ6|rcsb pdb:1NG2|rcsb pdb:1O7K|rcsb pdb:1OV3|rcsb pdb:1UEC|rcsb pdb:1W70|rcsb pdb:1WLP|reactome:R-HSA-1222556|reactome:R-HSA-1236973|reactome:R-HSA-3299685|reactome:R-HSA-4420097|reactome:R-HSA-5668599|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|ensembl:ENSG00000158517(gene)|ensembl:ENST00000289473(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|refseq:NP_000256.4|dip:DIP-126N|mint:MINT-7300403(identity) - - - figure legend:t2 f6|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/11/17 2018/04/30 rogid:UnXrnD0zuJFCfL4g4YPKiskTxzo9606 rogid:cNIwxrttmz096/m5mr+NRK5D9Nc9606 intact-crc:85D54F18A0EF34FC|rigid:dxDpXZUkRfKSPwzJbQqiuXUQjVA false binding-associated region:455-516(MINT-7300399) binding-associated region:358-372(MINT-7300404) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P14598 uniprotkb:P19878 intact:EBI-395044|uniprotkb:A6NEH2|uniprotkb:A8K7S9|uniprotkb:O43842|uniprotkb:Q2PP07|uniprotkb:Q9BU90|uniprotkb:Q9BXI7|uniprotkb:Q9BXI8|uniprotkb:Q9UDV9|uniprotkb:Q9UMU2|uniprotkb:Q53FR5|ensembl:ENSP00000289473 intact:EBI-489611|uniprotkb:Q2PP06|uniprotkb:Q8NFC7|ensembl:ENSP00000356505|ensembl:ENSP00000356506|uniprotkb:Q9BV51|uniprotkb:B2R6Q1|uniprotkb:B4DKQ7|uniprotkb:B4DQA7|uniprotkb:E9PHJ2|uniprotkb:E9PHX3 psi-mi:ncf1_human(display_long)|uniprotkb:NCF1(gene name)|psi-mi:NCF1(display_short)|uniprotkb:Neutrophil NADPH oxidase factor 1(gene name synonym)|uniprotkb:47 kDa neutrophil oxidase factor(gene name synonym)|uniprotkb:p47-phox(gene name synonym)|uniprotkb:NCF-47K(gene name synonym)|uniprotkb:47 kDa autosomal chronic granulomatous disease protein(gene name synonym)|uniprotkb:Nox-organizing protein 2(gene name synonym)|uniprotkb:Nox organizer 2(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 1A(gene name synonym)|uniprotkb:NOXO2(gene name synonym)|uniprotkb:SH3PXD1A(gene name synonym) psi-mi:ncf2_human(display_long)|uniprotkb:NOXA2(gene name synonym)|uniprotkb:P67PHOX(gene name synonym)|uniprotkb:Neutrophil NADPH oxidase factor 2(gene name synonym)|uniprotkb:NADPH oxidase activator 2(gene name synonym)|uniprotkb:67 kDa neutrophil oxidase factor(gene name synonym)|uniprotkb:p67-phox(gene name synonym)|uniprotkb:NCF2(gene name)|psi-mi:NCF2(display_short) psi-mi:"MI:0017"(classical fluorescence spectroscopy) Massenet et al. (2005) pubmed:15657040|mint:MINT-7219111|doi:10.1074/jbc.M412897200|imex:IM-28305 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7456983|mint:MINT-7300380|imex:IM-28305-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006968"(cellular defense response)|go:"GO:0009055"(electron transfer activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016175"("superoxide-generating NAD(P)H oxidase activity")|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030425"(dendrite)|go:"GO:0032010"(phagolysosome)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045730"(respiratory burst)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060264"(regulation of respiratory burst involved in inflammatory response)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1903409"(reactive oxygen species biosynthetic process)|interpro:IPR001452(Src homology-3)|interpro:IPR001655(Neutrophil cytosol factor 1)|interpro:IPR001683(Phox-like)|interpro:IPR015039(NADPH oxidase subunit p47Phox, C terminal)|interpro:IPR032136|interpro:IPR034909|interpro:IPR035756|interpro:IPR035757|interpro:IPR036028|interpro:IPR036871|mint:P14598|rcsb pdb:1GD5|rcsb pdb:1K4U|rcsb pdb:1KQ6|rcsb pdb:1NG2|rcsb pdb:1O7K|rcsb pdb:1OV3|rcsb pdb:1UEC|rcsb pdb:1W70|rcsb pdb:1WLP|reactome:R-HSA-1222556|reactome:R-HSA-1236973|reactome:R-HSA-3299685|reactome:R-HSA-4420097|reactome:R-HSA-5668599|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|ensembl:ENSG00000158517(gene)|ensembl:ENST00000289473(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|refseq:NP_000256.4|dip:DIP-126N|mint:MINT-7300387(identity) rcsb pdb:2DMO|reactome:R-HSA-1222556|reactome:R-HSA-1236973|reactome:R-HSA-3299685|reactome:R-HSA-4420097|reactome:R-HSA-5668599|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|rcsb pdb:1WM5|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0045087"(innate immune response)|go:"GO:0045730"(respiratory burst)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001452(Src homology-3)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR034885|interpro:IPR034889|interpro:IPR035546|interpro:IPR036028|mint:P19878|rcsb pdb:1E96|rcsb pdb:1HH8|rcsb pdb:1K4U|rcsb pdb:1OEY|ensembl:ENSG00000116701(gene)|ensembl:ENST00000367535(transcript)|ensembl:ENST00000367536(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005829"(cytosol)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0006968"(cellular defense response)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009055"(electron transfer activity)|go:"GO:0016020"(membrane)|go:"GO:0016175"("superoxide-generating NAD(P)H oxidase activity")|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032010"(phagolysosome)|refseq:NP_000424.2|refseq:NP_001121123.1|refseq:NP_001177718.1|refseq:XP_011507882.1|refseq:XP_011507883.1|refseq:NP_001177723.1|dip:DIP-76N|mint:MINT-7300382(identity) - - - figure legend:t2 f6|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/11/17 2020/08/28 rogid:cNIwxrttmz096/m5mr+NRK5D9Nc9606 rogid:UnXrnD0zuJFCfL4g4YPKiskTxzo9606 intact-crc:3303B9E34C4E1463|rigid:dxDpXZUkRfKSPwzJbQqiuXUQjVA false binding-associated region:358-390(MINT-7300388) binding-associated region:455-516(MINT-7300383) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)