#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:A1Z9X0	uniprotkb:P10040	intact:EBI-160861|ensemblmetazoa:FBpp0292487|ensemblmetazoa:FBpp0292491|intact:EBI-2296820|intact:EBI-867915|intact:EBI-2027110|intact:EBI-2656028|uniprotkb:Q0E971|uniprotkb:Q0E972|uniprotkb:Q0E973|uniprotkb:Q0E974|uniprotkb:Q8MT38|uniprotkb:Q9GSZ3	intact:EBI-672928|uniprotkb:Q0KI19|uniprotkb:Q8MSX5|uniprotkb:Q9VC97|ensemblmetazoa:FBpp0083987	psi-mi:apkc_drome(display_long)|uniprotkb:aPKC(gene name)|psi-mi:aPKC(display_short)|uniprotkb:CG30475(orf name)	psi-mi:crb_drome(display_long)|uniprotkb:95F(gene name synonym)|uniprotkb:crb(gene name)|psi-mi:crb(display_short)|uniprotkb:CG6383(orf name)	psi-mi:"MI:0096"(pull down)	Sotillos et al. (2004)	pubmed:15302858|imex:IM-20285	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2296816|imex:IM-20285-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001036541.1|refseq:NP_524892.2|flybase:FBgn0261854|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0045176"(apical protein localization)|go:"GO:0045179"(apical cortex)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0045196"(establishment or maintenance of neuroblast polarity)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0046667"(compound eye retinal cell programmed cell death)|go:"GO:0046872"(metal ion binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051601"(exocyst localization)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090163"(establishment of epithelial cell planar polarity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140591"(nuclear envelope budding)|go:"GO:1904580"(regulation of intracellular mRNA localization)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012233(Protein kinase C, zeta/iota)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:0035331"(negative regulation of hippo signaling)|ensemblmetazoa:FBgn0261854(gene)|ensemblmetazoa:FBtr0303430(transcript)|ensemblmetazoa:FBtr0303434(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007294"(germarium-derived oocyte fate determination)|go:"GO:0007314"(oocyte anterior/posterior axis specification)|go:"GO:0007416"(synapse assembly)|go:"GO:0007423"(sensory organ development)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0007613"(memory)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016332"(establishment or maintenance of polarity of embryonic epithelium)|go:"GO:0016334"(establishment or maintenance of polarity of follicular epithelium)|go:"GO:0017022"(myosin binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030860"(regulation of polarized epithelial cell differentiation)|go:"GO:0034332"(adherens junction organization)|go:"GO:0035003"(subapical complex)|go:"GO:0035011"(melanotic encapsulation of foreign target)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034659|interpro:IPR034877|reactome:R-DME-2173791|reactome:R-DME-5218921|reactome:R-DME-9634635|refseq:NP_001036542.1|refseq:NP_001036543.1|refseq:NP_001036544.1|refseq:NP_001036545.1	refseq:NP_001036751.1|refseq:NP_524480.2|flybase:FBgn0259685|dip:DIP-40915N|ensemblmetazoa:FBgn0259685(gene)|ensemblmetazoa:FBtr0084603(transcript)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0003383"(apical constriction)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005886"(plasma membrane)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007391"(dorsal closure)|go:"GO:0007399"(nervous system development)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007443"(Malpighian tubule morphogenesis)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016028"(rhabdomere)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016332"(establishment or maintenance of polarity of embryonic epithelium)|go:"GO:0016334"(establishment or maintenance of polarity of follicular epithelium)|go:"GO:0030507"(spectrin binding)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034332"(adherens junction organization)|go:"GO:0035002"(liquid clearance, open tracheal system)|go:"GO:0035003"(subapical complex)|go:"GO:0035088"(establishment or maintenance of apical/basal cell polarity)|go:"GO:0035090"(maintenance of apical/basal cell polarity)|go:"GO:0035239"(tube morphogenesis)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0042051"(compound eye photoreceptor development)|go:"GO:0042052"(rhabdomere development)|go:"GO:0045176"(apical protein localization)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0045218"(zonula adherens maintenance)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045570"(regulation of imaginal disc growth)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046664"(dorsal closure, amnioserosa morphology change)|go:"GO:0046665"(amnioserosa maintenance)|go:"GO:0048190"(wing disc dorsal/ventral pattern formation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0060438"(trachea development)|go:"GO:0061024"(membrane organization)|go:"GO:0061336"(cell morphogenesis involved in Malpighian tubule morphogenesis)|go:"GO:0061541"(rhabdomere morphogenesis)|go:"GO:0098813"(nuclear chromosome segregation)|go:"GO:0106036"(assembly of apicomedial cortex actomyosin)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018097|rcsb pdb:4WSI|rcsb pdb:4YL8	-	-	-	figure legend:2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/03/30	2014/10/16	rogid:w7Lc8l4/50NKAWamwS+Lzk6lbgA7227	rogid:eFe13WHwi5bdLUm1xQxhj22j9JU7227	intact-crc:B8CEF30F98E938CB|rigid:djGLQAk/kgTKJGZ0RbYAPIo/IJA	false	-	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:A1Z9X0	uniprotkb:Q9NB04	intact:EBI-160861|ensemblmetazoa:FBpp0292487|ensemblmetazoa:FBpp0292491|intact:EBI-2296820|intact:EBI-867915|intact:EBI-2027110|intact:EBI-2656028|uniprotkb:Q0E971|uniprotkb:Q0E972|uniprotkb:Q0E973|uniprotkb:Q0E974|uniprotkb:Q8MT38|uniprotkb:Q9GSZ3	intact:EBI-442573|ensemblmetazoa:FBpp0072662|ensemblmetazoa:FBpp0072664|ensemblmetazoa:FBpp0290839|uniprotkb:Q9UA56|uniprotkb:Q9XZ35	psi-mi:apkc_drome(display_long)|uniprotkb:aPKC(gene name)|psi-mi:aPKC(display_short)|uniprotkb:CG30475(orf name)	psi-mi:patj_drome(display_long)|uniprotkb:Patj(gene name)|psi-mi:Patj(display_short)|uniprotkb:CG12021(orf name)	psi-mi:"MI:0096"(pull down)	Sotillos et al. (2004)	pubmed:15302858|imex:IM-20285	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2296845|imex:IM-20285-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001036541.1|refseq:NP_524892.2|flybase:FBgn0261854|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0045176"(apical protein localization)|go:"GO:0045179"(apical cortex)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0045196"(establishment or maintenance of neuroblast polarity)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0046667"(compound eye retinal cell programmed cell death)|go:"GO:0046872"(metal ion binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051601"(exocyst localization)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090163"(establishment of epithelial cell planar polarity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140591"(nuclear envelope budding)|go:"GO:1904580"(regulation of intracellular mRNA localization)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012233(Protein kinase C, zeta/iota)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:0035331"(negative regulation of hippo signaling)|ensemblmetazoa:FBgn0261854(gene)|ensemblmetazoa:FBtr0303430(transcript)|ensemblmetazoa:FBtr0303434(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007294"(germarium-derived oocyte fate determination)|go:"GO:0007314"(oocyte anterior/posterior axis specification)|go:"GO:0007416"(synapse assembly)|go:"GO:0007423"(sensory organ development)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0007613"(memory)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016332"(establishment or maintenance of polarity of embryonic epithelium)|go:"GO:0016334"(establishment or maintenance of polarity of follicular epithelium)|go:"GO:0017022"(myosin binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030860"(regulation of polarized epithelial cell differentiation)|go:"GO:0034332"(adherens junction organization)|go:"GO:0035003"(subapical complex)|go:"GO:0035011"(melanotic encapsulation of foreign target)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034659|interpro:IPR034877|reactome:R-DME-2173791|reactome:R-DME-5218921|reactome:R-DME-9634635|refseq:NP_001036542.1|refseq:NP_001036543.1|refseq:NP_001036544.1|refseq:NP_001036545.1	ensemblmetazoa:FBgn0067864(gene)|ensemblmetazoa:FBtr0072779(transcript)|ensemblmetazoa:FBtr0072781(transcript)|go:"GO:0016332"(establishment or maintenance of polarity of embryonic epithelium)|go:"GO:0016333"(morphogenesis of follicular epithelium)|ensemblmetazoa:FBtr0301625(transcript)|go:"GO:0016334"(establishment or maintenance of polarity of follicular epithelium)|go:"GO:0032033"(myosin II light chain binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0001736"(establishment of planar polarity)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0034334"(adherens junction maintenance)|go:"GO:0005912"(adherens junction)|go:"GO:0035003"(subapical complex)|go:"GO:0035088"(establishment or maintenance of apical/basal cell polarity)|go:"GO:0035209"(pupal development)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0045176"(apical protein localization)|go:"GO:0005918"(septate junction)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0008594"(photoreceptor cell morphogenesis)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0045179"(apical cortex)|go:"GO:0045494"(photoreceptor cell maintenance)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR036034|reactome:R-DME-983168|go:"GO:0016327"(apicolateral plasma membrane)|refseq:NP_477342.1|refseq:NP_599144.1|refseq:NP_728674.1|flybase:FBgn0067864	-	-	-	figure legend:2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/03/30	2014/10/16	rogid:w7Lc8l4/50NKAWamwS+Lzk6lbgA7227	rogid:nZvAU5ZTGxioG6TZrufGJEm5hWM7227	intact-crc:0C884A002897C619|rigid:z0iBLNCKENQnaV698tpePhUW3RE	false	-	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P10040	uniprotkb:A1Z9X0	intact:EBI-672928|uniprotkb:Q0KI19|uniprotkb:Q8MSX5|uniprotkb:Q9VC97|ensemblmetazoa:FBpp0083987	intact:EBI-160861|ensemblmetazoa:FBpp0292487|ensemblmetazoa:FBpp0292491|intact:EBI-2296820|intact:EBI-867915|intact:EBI-2027110|intact:EBI-2656028|uniprotkb:Q0E971|uniprotkb:Q0E972|uniprotkb:Q0E973|uniprotkb:Q0E974|uniprotkb:Q8MT38|uniprotkb:Q9GSZ3	psi-mi:crb_drome(display_long)|uniprotkb:95F(gene name synonym)|uniprotkb:crb(gene name)|psi-mi:crb(display_short)|uniprotkb:CG6383(orf name)	psi-mi:apkc_drome(display_long)|uniprotkb:aPKC(gene name)|psi-mi:aPKC(display_short)|uniprotkb:CG30475(orf name)	psi-mi:"MI:0096"(pull down)	Sotillos et al. (2004)	pubmed:15302858|imex:IM-20285	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2296851|imex:IM-20285-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001036751.1|refseq:NP_524480.2|flybase:FBgn0259685|dip:DIP-40915N|ensemblmetazoa:FBgn0259685(gene)|ensemblmetazoa:FBtr0084603(transcript)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0003383"(apical constriction)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005886"(plasma membrane)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007391"(dorsal closure)|go:"GO:0007399"(nervous system development)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007443"(Malpighian tubule morphogenesis)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016028"(rhabdomere)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016332"(establishment or maintenance of polarity of embryonic epithelium)|go:"GO:0016334"(establishment or maintenance of polarity of follicular epithelium)|go:"GO:0030507"(spectrin binding)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034332"(adherens junction organization)|go:"GO:0035002"(liquid clearance, open tracheal system)|go:"GO:0035003"(subapical complex)|go:"GO:0035088"(establishment or maintenance of apical/basal cell polarity)|go:"GO:0035090"(maintenance of apical/basal cell polarity)|go:"GO:0035239"(tube morphogenesis)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0042051"(compound eye photoreceptor development)|go:"GO:0042052"(rhabdomere development)|go:"GO:0045176"(apical protein localization)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0045218"(zonula adherens maintenance)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045570"(regulation of imaginal disc growth)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046664"(dorsal closure, amnioserosa morphology change)|go:"GO:0046665"(amnioserosa maintenance)|go:"GO:0048190"(wing disc dorsal/ventral pattern formation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0060438"(trachea development)|go:"GO:0061024"(membrane organization)|go:"GO:0061336"(cell morphogenesis involved in Malpighian tubule morphogenesis)|go:"GO:0061541"(rhabdomere morphogenesis)|go:"GO:0098813"(nuclear chromosome segregation)|go:"GO:0106036"(assembly of apicomedial cortex actomyosin)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018097|rcsb pdb:4WSI|rcsb pdb:4YL8	refseq:NP_001036541.1|refseq:NP_524892.2|flybase:FBgn0261854|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0045176"(apical protein localization)|go:"GO:0045179"(apical cortex)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0045196"(establishment or maintenance of neuroblast polarity)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0046667"(compound eye retinal cell programmed cell death)|go:"GO:0046872"(metal ion binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051601"(exocyst localization)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090163"(establishment of epithelial cell planar polarity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140591"(nuclear envelope budding)|go:"GO:1904580"(regulation of intracellular mRNA localization)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012233(Protein kinase C, zeta/iota)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:0035331"(negative regulation of hippo signaling)|ensemblmetazoa:FBgn0261854(gene)|ensemblmetazoa:FBtr0303430(transcript)|ensemblmetazoa:FBtr0303434(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007294"(germarium-derived oocyte fate determination)|go:"GO:0007314"(oocyte anterior/posterior axis specification)|go:"GO:0007416"(synapse assembly)|go:"GO:0007423"(sensory organ development)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0007613"(memory)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016332"(establishment or maintenance of polarity of embryonic epithelium)|go:"GO:0016334"(establishment or maintenance of polarity of follicular epithelium)|go:"GO:0017022"(myosin binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030860"(regulation of polarized epithelial cell differentiation)|go:"GO:0034332"(adherens junction organization)|go:"GO:0035003"(subapical complex)|go:"GO:0035011"(melanotic encapsulation of foreign target)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034659|interpro:IPR034877|reactome:R-DME-2173791|reactome:R-DME-5218921|reactome:R-DME-9634635|refseq:NP_001036542.1|refseq:NP_001036543.1|refseq:NP_001036544.1|refseq:NP_001036545.1	-	-	-	figure legend:2C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/03/30	2014/10/16	rogid:eFe13WHwi5bdLUm1xQxhj22j9JU7227	rogid:w7Lc8l4/50NKAWamwS+Lzk6lbgA7227	intact-crc:40DE299655B2C5A3|rigid:c9c5vy3/ScxSPj1E8pCn4BMSiPk	false	glutathione s tranferase tag:?-?|necessary binding region:2142-2146|mutation decreasing interaction:2115-2115,2118-2118,2120-2120,2122-2122|mutation decreasing interaction:2115-2115,2118-2118|sufficient binding region:2110..2110-2146	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P10040	uniprotkb:Q9NB04	intact:EBI-672928|uniprotkb:Q0KI19|uniprotkb:Q8MSX5|uniprotkb:Q9VC97|ensemblmetazoa:FBpp0083987	intact:EBI-442573|ensemblmetazoa:FBpp0072662|ensemblmetazoa:FBpp0072664|ensemblmetazoa:FBpp0290839|uniprotkb:Q9UA56|uniprotkb:Q9XZ35	psi-mi:crb_drome(display_long)|uniprotkb:95F(gene name synonym)|uniprotkb:crb(gene name)|psi-mi:crb(display_short)|uniprotkb:CG6383(orf name)	psi-mi:patj_drome(display_long)|uniprotkb:Patj(gene name)|psi-mi:Patj(display_short)|uniprotkb:CG12021(orf name)	psi-mi:"MI:0096"(pull down)	Sotillos et al. (2004)	pubmed:15302858|imex:IM-20285	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2296851|imex:IM-20285-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001036751.1|refseq:NP_524480.2|flybase:FBgn0259685|dip:DIP-40915N|ensemblmetazoa:FBgn0259685(gene)|ensemblmetazoa:FBtr0084603(transcript)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0003383"(apical constriction)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005886"(plasma membrane)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007391"(dorsal closure)|go:"GO:0007399"(nervous system development)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007443"(Malpighian tubule morphogenesis)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016028"(rhabdomere)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016332"(establishment or maintenance of polarity of embryonic epithelium)|go:"GO:0016334"(establishment or maintenance of polarity of follicular epithelium)|go:"GO:0030507"(spectrin binding)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034332"(adherens junction organization)|go:"GO:0035002"(liquid clearance, open tracheal system)|go:"GO:0035003"(subapical complex)|go:"GO:0035088"(establishment or maintenance of apical/basal cell polarity)|go:"GO:0035090"(maintenance of apical/basal cell polarity)|go:"GO:0035239"(tube morphogenesis)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0042051"(compound eye photoreceptor development)|go:"GO:0042052"(rhabdomere development)|go:"GO:0045176"(apical protein localization)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0045218"(zonula adherens maintenance)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045570"(regulation of imaginal disc growth)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046664"(dorsal closure, amnioserosa morphology change)|go:"GO:0046665"(amnioserosa maintenance)|go:"GO:0048190"(wing disc dorsal/ventral pattern formation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0060438"(trachea development)|go:"GO:0061024"(membrane organization)|go:"GO:0061336"(cell morphogenesis involved in Malpighian tubule morphogenesis)|go:"GO:0061541"(rhabdomere morphogenesis)|go:"GO:0098813"(nuclear chromosome segregation)|go:"GO:0106036"(assembly of apicomedial cortex actomyosin)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018097|rcsb pdb:4WSI|rcsb pdb:4YL8	ensemblmetazoa:FBgn0067864(gene)|ensemblmetazoa:FBtr0072779(transcript)|ensemblmetazoa:FBtr0072781(transcript)|go:"GO:0016332"(establishment or maintenance of polarity of embryonic epithelium)|go:"GO:0016333"(morphogenesis of follicular epithelium)|ensemblmetazoa:FBtr0301625(transcript)|go:"GO:0016334"(establishment or maintenance of polarity of follicular epithelium)|go:"GO:0032033"(myosin II light chain binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0001736"(establishment of planar polarity)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0034334"(adherens junction maintenance)|go:"GO:0005912"(adherens junction)|go:"GO:0035003"(subapical complex)|go:"GO:0035088"(establishment or maintenance of apical/basal cell polarity)|go:"GO:0035209"(pupal development)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0045176"(apical protein localization)|go:"GO:0005918"(septate junction)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0008594"(photoreceptor cell morphogenesis)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0045179"(apical cortex)|go:"GO:0045494"(photoreceptor cell maintenance)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR036034|reactome:R-DME-983168|go:"GO:0016327"(apicolateral plasma membrane)|refseq:NP_477342.1|refseq:NP_599144.1|refseq:NP_728674.1|flybase:FBgn0067864	-	-	-	figure legend:2C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/03/30	2014/10/16	rogid:eFe13WHwi5bdLUm1xQxhj22j9JU7227	rogid:nZvAU5ZTGxioG6TZrufGJEm5hWM7227	intact-crc:40DE299655B2C5A3|rigid:c9c5vy3/ScxSPj1E8pCn4BMSiPk	false	glutathione s tranferase tag:?-?|necessary binding region:2142-2146|mutation decreasing interaction:2115-2115,2118-2118,2120-2120,2122-2122|mutation decreasing interaction:2115-2115,2118-2118|sufficient binding region:2110..2110-2146	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9NB04	uniprotkb:A1Z9X0	intact:EBI-442573|ensemblmetazoa:FBpp0072662|ensemblmetazoa:FBpp0072664|ensemblmetazoa:FBpp0290839|uniprotkb:Q9UA56|uniprotkb:Q9XZ35	intact:EBI-160861|ensemblmetazoa:FBpp0292487|ensemblmetazoa:FBpp0292491|intact:EBI-2296820|intact:EBI-867915|intact:EBI-2027110|intact:EBI-2656028|uniprotkb:Q0E971|uniprotkb:Q0E972|uniprotkb:Q0E973|uniprotkb:Q0E974|uniprotkb:Q8MT38|uniprotkb:Q9GSZ3	psi-mi:patj_drome(display_long)|uniprotkb:Patj(gene name)|psi-mi:Patj(display_short)|uniprotkb:CG12021(orf name)	psi-mi:apkc_drome(display_long)|uniprotkb:aPKC(gene name)|psi-mi:aPKC(display_short)|uniprotkb:CG30475(orf name)	psi-mi:"MI:0096"(pull down)	Sotillos et al. (2004)	pubmed:15302858|imex:IM-20285	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2296885|imex:IM-20285-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:FBgn0067864(gene)|ensemblmetazoa:FBtr0072779(transcript)|ensemblmetazoa:FBtr0072781(transcript)|go:"GO:0016332"(establishment or maintenance of polarity of embryonic epithelium)|go:"GO:0016333"(morphogenesis of follicular epithelium)|ensemblmetazoa:FBtr0301625(transcript)|go:"GO:0016334"(establishment or maintenance of polarity of follicular epithelium)|go:"GO:0032033"(myosin II light chain binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0001736"(establishment of planar polarity)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0034334"(adherens junction maintenance)|go:"GO:0005912"(adherens junction)|go:"GO:0035003"(subapical complex)|go:"GO:0035088"(establishment or maintenance of apical/basal cell polarity)|go:"GO:0035209"(pupal development)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0045176"(apical protein localization)|go:"GO:0005918"(septate junction)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0008594"(photoreceptor cell morphogenesis)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0045179"(apical cortex)|go:"GO:0045494"(photoreceptor cell maintenance)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR036034|reactome:R-DME-983168|go:"GO:0016327"(apicolateral plasma membrane)|refseq:NP_477342.1|refseq:NP_599144.1|refseq:NP_728674.1|flybase:FBgn0067864	refseq:NP_001036541.1|refseq:NP_524892.2|flybase:FBgn0261854|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0045176"(apical protein localization)|go:"GO:0045179"(apical cortex)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0045196"(establishment or maintenance of neuroblast polarity)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0046667"(compound eye retinal cell programmed cell death)|go:"GO:0046872"(metal ion binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051601"(exocyst localization)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090163"(establishment of epithelial cell planar polarity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140591"(nuclear envelope budding)|go:"GO:1904580"(regulation of intracellular mRNA localization)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012233(Protein kinase C, zeta/iota)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:0035331"(negative regulation of hippo signaling)|ensemblmetazoa:FBgn0261854(gene)|ensemblmetazoa:FBtr0303430(transcript)|ensemblmetazoa:FBtr0303434(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007294"(germarium-derived oocyte fate determination)|go:"GO:0007314"(oocyte anterior/posterior axis specification)|go:"GO:0007416"(synapse assembly)|go:"GO:0007423"(sensory organ development)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0007613"(memory)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016332"(establishment or maintenance of polarity of embryonic epithelium)|go:"GO:0016334"(establishment or maintenance of polarity of follicular epithelium)|go:"GO:0017022"(myosin binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030860"(regulation of polarized epithelial cell differentiation)|go:"GO:0034332"(adherens junction organization)|go:"GO:0035003"(subapical complex)|go:"GO:0035011"(melanotic encapsulation of foreign target)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034659|interpro:IPR034877|reactome:R-DME-2173791|reactome:R-DME-5218921|reactome:R-DME-9634635|refseq:NP_001036542.1|refseq:NP_001036543.1|refseq:NP_001036544.1|refseq:NP_001036545.1	-	-	-	figure legend:2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/03/30	2014/10/16	rogid:nZvAU5ZTGxioG6TZrufGJEm5hWM7227	rogid:w7Lc8l4/50NKAWamwS+Lzk6lbgA7227	intact-crc:63E28B094F2603A9|rigid:z0iBLNCKENQnaV698tpePhUW3RE	false	glutathione s tranferase tag:?-?	his tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:A1Z9X0	uniprotkb:P10040	intact:EBI-160861|ensemblmetazoa:FBpp0292487|ensemblmetazoa:FBpp0292491|intact:EBI-2296820|intact:EBI-867915|intact:EBI-2027110|intact:EBI-2656028|uniprotkb:Q0E971|uniprotkb:Q0E972|uniprotkb:Q0E973|uniprotkb:Q0E974|uniprotkb:Q8MT38|uniprotkb:Q9GSZ3	intact:EBI-672928|uniprotkb:Q0KI19|uniprotkb:Q8MSX5|uniprotkb:Q9VC97|ensemblmetazoa:FBpp0083987	psi-mi:apkc_drome(display_long)|uniprotkb:aPKC(gene name)|psi-mi:aPKC(display_short)|uniprotkb:CG30475(orf name)	psi-mi:crb_drome(display_long)|uniprotkb:95F(gene name synonym)|uniprotkb:crb(gene name)|psi-mi:crb(display_short)|uniprotkb:CG6383(orf name)	psi-mi:"MI:0096"(pull down)	Sotillos et al. (2004)	pubmed:15302858|imex:IM-20285	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2296893|imex:IM-20285-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001036541.1|refseq:NP_524892.2|flybase:FBgn0261854|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0045176"(apical protein localization)|go:"GO:0045179"(apical cortex)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0045196"(establishment or maintenance of neuroblast polarity)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0046667"(compound eye retinal cell programmed cell death)|go:"GO:0046872"(metal ion binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051601"(exocyst localization)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090163"(establishment of epithelial cell planar polarity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140591"(nuclear envelope budding)|go:"GO:1904580"(regulation of intracellular mRNA localization)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012233(Protein kinase C, zeta/iota)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:0035331"(negative regulation of hippo signaling)|ensemblmetazoa:FBgn0261854(gene)|ensemblmetazoa:FBtr0303430(transcript)|ensemblmetazoa:FBtr0303434(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007294"(germarium-derived oocyte fate determination)|go:"GO:0007314"(oocyte anterior/posterior axis specification)|go:"GO:0007416"(synapse assembly)|go:"GO:0007423"(sensory organ development)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0007613"(memory)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016332"(establishment or maintenance of polarity of embryonic epithelium)|go:"GO:0016334"(establishment or maintenance of polarity of follicular epithelium)|go:"GO:0017022"(myosin binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030860"(regulation of polarized epithelial cell differentiation)|go:"GO:0034332"(adherens junction organization)|go:"GO:0035003"(subapical complex)|go:"GO:0035011"(melanotic encapsulation of foreign target)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034659|interpro:IPR034877|reactome:R-DME-2173791|reactome:R-DME-5218921|reactome:R-DME-9634635|refseq:NP_001036542.1|refseq:NP_001036543.1|refseq:NP_001036544.1|refseq:NP_001036545.1	refseq:NP_001036751.1|refseq:NP_524480.2|flybase:FBgn0259685|dip:DIP-40915N|ensemblmetazoa:FBgn0259685(gene)|ensemblmetazoa:FBtr0084603(transcript)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0003383"(apical constriction)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005886"(plasma membrane)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007391"(dorsal closure)|go:"GO:0007399"(nervous system development)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007443"(Malpighian tubule morphogenesis)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016028"(rhabdomere)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016332"(establishment or maintenance of polarity of embryonic epithelium)|go:"GO:0016334"(establishment or maintenance of polarity of follicular epithelium)|go:"GO:0030507"(spectrin binding)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034332"(adherens junction organization)|go:"GO:0035002"(liquid clearance, open tracheal system)|go:"GO:0035003"(subapical complex)|go:"GO:0035088"(establishment or maintenance of apical/basal cell polarity)|go:"GO:0035090"(maintenance of apical/basal cell polarity)|go:"GO:0035239"(tube morphogenesis)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0042051"(compound eye photoreceptor development)|go:"GO:0042052"(rhabdomere development)|go:"GO:0045176"(apical protein localization)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0045218"(zonula adherens maintenance)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045570"(regulation of imaginal disc growth)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046664"(dorsal closure, amnioserosa morphology change)|go:"GO:0046665"(amnioserosa maintenance)|go:"GO:0048190"(wing disc dorsal/ventral pattern formation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0060438"(trachea development)|go:"GO:0061024"(membrane organization)|go:"GO:0061336"(cell morphogenesis involved in Malpighian tubule morphogenesis)|go:"GO:0061541"(rhabdomere morphogenesis)|go:"GO:0098813"(nuclear chromosome segregation)|go:"GO:0106036"(assembly of apicomedial cortex actomyosin)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018097|rcsb pdb:4WSI|rcsb pdb:4YL8	-	-	-	figure legend:2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/03/30	2014/10/16	rogid:w7Lc8l4/50NKAWamwS+Lzk6lbgA7227	rogid:eFe13WHwi5bdLUm1xQxhj22j9JU7227	intact-crc:DDCC2386E0BEAEB2|rigid:djGLQAk/kgTKJGZ0RbYAPIo/IJA	false	his tag:?-?	glutathione s tranferase tag:?-?|sufficient binding region:2110..2110-2146	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P41743	uniprotkb:P10040	intact:EBI-286199|uniprotkb:Q8WW06|uniprotkb:D3DNQ4|ensembl:ENSP00000295797	intact:EBI-672928|uniprotkb:Q0KI19|uniprotkb:Q8MSX5|uniprotkb:Q9VC97|ensemblmetazoa:FBpp0083987	psi-mi:kpci_human(display_long)|uniprotkb:nPKC-iota(gene name synonym)|uniprotkb:Atypical protein kinase C-lambda/iota(gene name synonym)|uniprotkb:PRKCI(gene name)|psi-mi:PRKCI(display_short)|uniprotkb:DXS1179E(gene name synonym)	psi-mi:crb_drome(display_long)|uniprotkb:95F(gene name synonym)|uniprotkb:crb(gene name)|psi-mi:crb(display_short)|uniprotkb:CG6383(orf name)	psi-mi:"MI:0424"(protein kinase assay)	Sotillos et al. (2004)	pubmed:15302858|imex:IM-20285	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2296916|imex:IM-20285-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002731.4|dip:DIP-31311N|ensembl:ENSG00000163558(gene)|ensembl:ENST00000295797(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031252"(cell leading edge)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035089"(establishment of apical/basal cell polarity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046872"(metal ion binding)|go:"GO:0046903"(secretion)|go:"GO:0048194"(Golgi vesicle budding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0061024"(membrane organization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012233(Protein kinase C, zeta/iota)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034661|interpro:IPR034877|mint:P41743|rcsb pdb:1VD2|rcsb pdb:1WMH|rcsb pdb:1ZRZ|rcsb pdb:3A8W|rcsb pdb:3A8X|rcsb pdb:3ZH8|rcsb pdb:5LI1|rcsb pdb:5LI9|rcsb pdb:5LIH|rcsb pdb:6ILZ|reactome:R-HSA-1912408|reactome:R-HSA-209543|reactome:R-HSA-420029	refseq:NP_001036751.1|refseq:NP_524480.2|flybase:FBgn0259685|dip:DIP-40915N|ensemblmetazoa:FBgn0259685(gene)|ensemblmetazoa:FBtr0084603(transcript)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0003383"(apical constriction)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005886"(plasma membrane)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007391"(dorsal closure)|go:"GO:0007399"(nervous system development)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007443"(Malpighian tubule morphogenesis)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016028"(rhabdomere)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016332"(establishment or maintenance of polarity of embryonic epithelium)|go:"GO:0016334"(establishment or maintenance of polarity of follicular epithelium)|go:"GO:0030507"(spectrin binding)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034332"(adherens junction organization)|go:"GO:0035002"(liquid clearance, open tracheal system)|go:"GO:0035003"(subapical complex)|go:"GO:0035088"(establishment or maintenance of apical/basal cell polarity)|go:"GO:0035090"(maintenance of apical/basal cell polarity)|go:"GO:0035239"(tube morphogenesis)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0042051"(compound eye photoreceptor development)|go:"GO:0042052"(rhabdomere development)|go:"GO:0045176"(apical protein localization)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0045218"(zonula adherens maintenance)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045570"(regulation of imaginal disc growth)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046664"(dorsal closure, amnioserosa morphology change)|go:"GO:0046665"(amnioserosa maintenance)|go:"GO:0048190"(wing disc dorsal/ventral pattern formation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0060438"(trachea development)|go:"GO:0061024"(membrane organization)|go:"GO:0061336"(cell morphogenesis involved in Malpighian tubule morphogenesis)|go:"GO:0061541"(rhabdomere morphogenesis)|go:"GO:0098813"(nuclear chromosome segregation)|go:"GO:0106036"(assembly of apicomedial cortex actomyosin)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018097|rcsb pdb:4WSI|rcsb pdb:4YL8	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/03/30	2014/10/16	rogid:v8sZdKjtlBejk0MH/9gwOjRqy+49606	rogid:eFe13WHwi5bdLUm1xQxhj22j9JU7227	intact-crc:E13C4EA93ADB7C35|rigid:vimegB9oaGfQ/gtkOXIdG2pRJn0	false	his tag:?-?	glutathione s tranferase tag:?-?|mutation:2120-2120,2122-2122,2118-2118,2115-2115|mutation:2115-2115,2118-2118|sufficient binding region:2110..2110-2146..2146	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)