#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P04925	uniprotkb:Q60631	intact:EBI-768613|ensembl:ENSMUSP00000088833	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	psi-mi:prio_mouse(display_long)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:Prnp(gene name)|psi-mi:Prnp(display_short)|uniprotkb:Prn-p(gene name synonym)|uniprotkb:Prp(gene name synonym)	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:"MI:0016"(circular dichroism)	Lysek et al. (2004)	pubmed:15301538|mint:MINT-7219199|doi:10.1021/bi0494828	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7281801|mint:MINT-7312019	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001265185.1|refseq:NP_035300.1|dip:DIP-4N|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035690"|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046688"(response to copper ion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051087"(chaperone binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000817(Prion protein)|interpro:IPR022416|interpro:IPR025860|ensembl:ENSMUSG00000079037(gene)|ensembl:ENSMUST00000091288(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007611"(learning or memory)|go:"GO:0008017"(microtubule binding)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031648"(protein destabilization)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|interpro:IPR036924|mint:P04925|rcsb pdb:1AG2|rcsb pdb:1XYX|rcsb pdb:1Y15|rcsb pdb:1Y16|rcsb pdb:2K5O|rcsb pdb:2KFM|rcsb pdb:2KFO|rcsb pdb:2KU5|rcsb pdb:2KU6|rcsb pdb:2L1D|rcsb pdb:2L1E|rcsb pdb:2L1H|rcsb pdb:2L1K|rcsb pdb:2L39|rcsb pdb:2L40|rcsb pdb:3NVG|rcsb pdb:3NVH|rcsb pdb:4H88|rcsb pdb:4J8R|rcsb pdb:4MA7|rcsb pdb:4MA8|rcsb pdb:6AQ7|rcsb pdb:6HER|rcsb pdb:6HHD|reactome:R-MMU-9609523|mint:MINT-7312021(identity)	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695|mint:MINT-7312022(identity)	-	-	-	comment:homomint|figure legend:f2a f2c|comment:domino|comment:mint|curation depth:mimix curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/12/04	2014/10/16	rogid:TRLrkh8lISmZdE7v3kEBmlkunmo10090	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	intact-crc:213075637A1452EC|rigid:3Syfv9OwGiBFxBo5svW03X7YEuE	false	binding-associated region:90-231(MINT-7312030)	binding-associated region:156-215(MINT-7312025)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q60631	uniprotkb:P04925	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	intact:EBI-768613|ensembl:ENSMUSP00000088833	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:prio_mouse(display_long)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:Prnp(gene name)|psi-mi:Prnp(display_short)|uniprotkb:Prn-p(gene name synonym)|uniprotkb:Prp(gene name synonym)	psi-mi:"MI:0016"(circular dichroism)	Lysek et al. (2004)	pubmed:15301538|mint:MINT-7219199|doi:10.1021/bi0494828	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7281822|mint:MINT-7312034	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695|mint:MINT-7312036(identity)	refseq:NP_001265185.1|refseq:NP_035300.1|dip:DIP-4N|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035690"|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046688"(response to copper ion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051087"(chaperone binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000817(Prion protein)|interpro:IPR022416|interpro:IPR025860|ensembl:ENSMUSG00000079037(gene)|ensembl:ENSMUST00000091288(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007611"(learning or memory)|go:"GO:0008017"(microtubule binding)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031648"(protein destabilization)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|interpro:IPR036924|mint:P04925|rcsb pdb:1AG2|rcsb pdb:1XYX|rcsb pdb:1Y15|rcsb pdb:1Y16|rcsb pdb:2K5O|rcsb pdb:2KFM|rcsb pdb:2KFO|rcsb pdb:2KU5|rcsb pdb:2KU6|rcsb pdb:2L1D|rcsb pdb:2L1E|rcsb pdb:2L1H|rcsb pdb:2L1K|rcsb pdb:2L39|rcsb pdb:2L40|rcsb pdb:3NVG|rcsb pdb:3NVH|rcsb pdb:4H88|rcsb pdb:4J8R|rcsb pdb:4MA7|rcsb pdb:4MA8|rcsb pdb:6AQ7|rcsb pdb:6HER|rcsb pdb:6HHD|reactome:R-MMU-9609523|mint:MINT-7312041(identity)	-	-	-	comment:homomint|comment:domino|comment:mint|figure legend:f2b f2d|curation depth:mimix curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/12/04	2014/10/16	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	rogid:TRLrkh8lISmZdE7v3kEBmlkunmo10090	intact-crc:6795C23C09ACED93|rigid:3Syfv9OwGiBFxBo5svW03X7YEuE	false	binding-associated region:156-215(MINT-7312037)	binding-associated region:121-231(MINT-7312042)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q60631	uniprotkb:P04925	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	intact:EBI-768613|ensembl:ENSMUSP00000088833	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:prio_mouse(display_long)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:Prnp(gene name)|psi-mi:Prnp(display_short)|uniprotkb:Prn-p(gene name synonym)|uniprotkb:Prp(gene name synonym)	psi-mi:"MI:0017"(classical fluorescence spectroscopy)	Lysek et al. (2004)	pubmed:15301538|mint:MINT-7219199|doi:10.1021/bi0494828	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7281853|mint:MINT-7312051	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695|mint:MINT-7312053(identity)	refseq:NP_001265185.1|refseq:NP_035300.1|dip:DIP-4N|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035690"|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046688"(response to copper ion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051087"(chaperone binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000817(Prion protein)|interpro:IPR022416|interpro:IPR025860|ensembl:ENSMUSG00000079037(gene)|ensembl:ENSMUST00000091288(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007611"(learning or memory)|go:"GO:0008017"(microtubule binding)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031648"(protein destabilization)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|interpro:IPR036924|mint:P04925|rcsb pdb:1AG2|rcsb pdb:1XYX|rcsb pdb:1Y15|rcsb pdb:1Y16|rcsb pdb:2K5O|rcsb pdb:2KFM|rcsb pdb:2KFO|rcsb pdb:2KU5|rcsb pdb:2KU6|rcsb pdb:2L1D|rcsb pdb:2L1E|rcsb pdb:2L1H|rcsb pdb:2L1K|rcsb pdb:2L39|rcsb pdb:2L40|rcsb pdb:3NVG|rcsb pdb:3NVH|rcsb pdb:4H88|rcsb pdb:4J8R|rcsb pdb:4MA7|rcsb pdb:4MA8|rcsb pdb:6AQ7|rcsb pdb:6HER|rcsb pdb:6HHD|reactome:R-MMU-9609523|mint:MINT-7312058(identity)	-	-	-	comment:homomint|comment:domino|comment:mint|figure legend:f3|curation depth:mimix curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/12/04	2014/10/16	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	rogid:TRLrkh8lISmZdE7v3kEBmlkunmo10090	intact-crc:8A6615D67C0365E9|rigid:3Syfv9OwGiBFxBo5svW03X7YEuE	false	binding-associated region:156-215(MINT-7312054)	binding-associated region:90-231(MINT-7312059)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04925	uniprotkb:Q60631	intact:EBI-768613|ensembl:ENSMUSP00000088833	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	psi-mi:prio_mouse(display_long)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:Prnp(gene name)|psi-mi:Prnp(display_short)|uniprotkb:Prn-p(gene name synonym)|uniprotkb:Prp(gene name synonym)	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:"MI:0017"(classical fluorescence spectroscopy)	Lysek et al. (2004)	pubmed:15301538|mint:MINT-7219199|doi:10.1021/bi0494828	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7281907|mint:MINT-7312104	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001265185.1|refseq:NP_035300.1|dip:DIP-4N|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035690"|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046688"(response to copper ion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051087"(chaperone binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000817(Prion protein)|interpro:IPR022416|interpro:IPR025860|ensembl:ENSMUSG00000079037(gene)|ensembl:ENSMUST00000091288(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007611"(learning or memory)|go:"GO:0008017"(microtubule binding)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031648"(protein destabilization)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|interpro:IPR036924|mint:P04925|rcsb pdb:1AG2|rcsb pdb:1XYX|rcsb pdb:1Y15|rcsb pdb:1Y16|rcsb pdb:2K5O|rcsb pdb:2KFM|rcsb pdb:2KFO|rcsb pdb:2KU5|rcsb pdb:2KU6|rcsb pdb:2L1D|rcsb pdb:2L1E|rcsb pdb:2L1H|rcsb pdb:2L1K|rcsb pdb:2L39|rcsb pdb:2L40|rcsb pdb:3NVG|rcsb pdb:3NVH|rcsb pdb:4H88|rcsb pdb:4J8R|rcsb pdb:4MA7|rcsb pdb:4MA8|rcsb pdb:6AQ7|rcsb pdb:6HER|rcsb pdb:6HHD|reactome:R-MMU-9609523|mint:MINT-7312112(identity)	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695|mint:MINT-7312107(identity)	-	-	-	figure legend:f4c|comment:homomint|comment:domino|comment:mint|curation depth:mimix curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:5.5x10^-6(molar)	2009/12/04	2014/10/16	rogid:TRLrkh8lISmZdE7v3kEBmlkunmo10090	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	intact-crc:51B634B693D1FF36|rigid:3Syfv9OwGiBFxBo5svW03X7YEuE	false	binding-associated region:90-231(MINT-7312113)	binding-associated region:156-215(MINT-7312108)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04925	uniprotkb:Q60631	intact:EBI-768613|ensembl:ENSMUSP00000088833	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	psi-mi:prio_mouse(display_long)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:Prnp(gene name)|psi-mi:Prnp(display_short)|uniprotkb:Prn-p(gene name synonym)|uniprotkb:Prp(gene name synonym)	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:"MI:0017"(classical fluorescence spectroscopy)	Lysek et al. (2004)	pubmed:15301538|mint:MINT-7219199|doi:10.1021/bi0494828	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7281874|mint:MINT-7312067	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001265185.1|refseq:NP_035300.1|dip:DIP-4N|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035690"|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046688"(response to copper ion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051087"(chaperone binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000817(Prion protein)|interpro:IPR022416|interpro:IPR025860|ensembl:ENSMUSG00000079037(gene)|ensembl:ENSMUST00000091288(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007611"(learning or memory)|go:"GO:0008017"(microtubule binding)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031648"(protein destabilization)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|interpro:IPR036924|mint:P04925|rcsb pdb:1AG2|rcsb pdb:1XYX|rcsb pdb:1Y15|rcsb pdb:1Y16|rcsb pdb:2K5O|rcsb pdb:2KFM|rcsb pdb:2KFO|rcsb pdb:2KU5|rcsb pdb:2KU6|rcsb pdb:2L1D|rcsb pdb:2L1E|rcsb pdb:2L1H|rcsb pdb:2L1K|rcsb pdb:2L39|rcsb pdb:2L40|rcsb pdb:3NVG|rcsb pdb:3NVH|rcsb pdb:4H88|rcsb pdb:4J8R|rcsb pdb:4MA7|rcsb pdb:4MA8|rcsb pdb:6AQ7|rcsb pdb:6HER|rcsb pdb:6HHD|reactome:R-MMU-9609523|mint:MINT-7312069(identity)	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695|mint:MINT-7312074(identity)	-	-	-	comment:homomint|comment:domino|comment:mint|figure legend:f4a f4b|curation depth:mimix curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:10.6x10^-6(molar)	2009/12/04	2014/10/16	rogid:TRLrkh8lISmZdE7v3kEBmlkunmo10090	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	intact-crc:0CABF7DE2D423065|rigid:3Syfv9OwGiBFxBo5svW03X7YEuE	false	binding-associated region:90-231(MINT-7312070)	binding-associated region:156-215(MINT-7312075)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q60631	uniprotkb:P04925	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	intact:EBI-768613|ensembl:ENSMUSP00000088833	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:prio_mouse(display_long)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:Prnp(gene name)|psi-mi:Prnp(display_short)|uniprotkb:Prn-p(gene name synonym)|uniprotkb:Prp(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Lysek et al. (2004)	pubmed:15301538|mint:MINT-7219199|doi:10.1021/bi0494828	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7281992|mint:MINT-7312124	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695|mint:MINT-7312132(identity)	refseq:NP_001265185.1|refseq:NP_035300.1|dip:DIP-4N|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035690"|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046688"(response to copper ion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051087"(chaperone binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000817(Prion protein)|interpro:IPR022416|interpro:IPR025860|ensembl:ENSMUSG00000079037(gene)|ensembl:ENSMUST00000091288(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007611"(learning or memory)|go:"GO:0008017"(microtubule binding)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031648"(protein destabilization)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|interpro:IPR036924|mint:P04925|rcsb pdb:1AG2|rcsb pdb:1XYX|rcsb pdb:1Y15|rcsb pdb:1Y16|rcsb pdb:2K5O|rcsb pdb:2KFM|rcsb pdb:2KFO|rcsb pdb:2KU5|rcsb pdb:2KU6|rcsb pdb:2L1D|rcsb pdb:2L1E|rcsb pdb:2L1H|rcsb pdb:2L1K|rcsb pdb:2L39|rcsb pdb:2L40|rcsb pdb:3NVG|rcsb pdb:3NVH|rcsb pdb:4H88|rcsb pdb:4J8R|rcsb pdb:4MA7|rcsb pdb:4MA8|rcsb pdb:6AQ7|rcsb pdb:6HER|rcsb pdb:6HHD|reactome:R-MMU-9609523|mint:MINT-7312127(identity)	-	-	-	comment:homomint|comment:domino|comment:mint|figure legend:f5a f5b f5c|curation depth:mimix curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/12/04	2014/10/16	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	rogid:TRLrkh8lISmZdE7v3kEBmlkunmo10090	intact-crc:87F8ADAB4EED2A51|rigid:3Syfv9OwGiBFxBo5svW03X7YEuE	false	binding-associated region:156-215(MINT-7312133)	binding-associated region:90-231(MINT-7312128)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04925	uniprotkb:Q60631	intact:EBI-768613|ensembl:ENSMUSP00000088833	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	psi-mi:prio_mouse(display_long)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:Prnp(gene name)|psi-mi:Prnp(display_short)|uniprotkb:Prn-p(gene name synonym)|uniprotkb:Prp(gene name synonym)	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Lysek et al. (2004)	pubmed:15301538|mint:MINT-7219199|doi:10.1021/bi0494828	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7282013|mint:MINT-7312143	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001265185.1|refseq:NP_035300.1|dip:DIP-4N|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035690"|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046688"(response to copper ion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051087"(chaperone binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000817(Prion protein)|interpro:IPR022416|interpro:IPR025860|ensembl:ENSMUSG00000079037(gene)|ensembl:ENSMUST00000091288(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007611"(learning or memory)|go:"GO:0008017"(microtubule binding)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031648"(protein destabilization)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|interpro:IPR036924|mint:P04925|rcsb pdb:1AG2|rcsb pdb:1XYX|rcsb pdb:1Y15|rcsb pdb:1Y16|rcsb pdb:2K5O|rcsb pdb:2KFM|rcsb pdb:2KFO|rcsb pdb:2KU5|rcsb pdb:2KU6|rcsb pdb:2L1D|rcsb pdb:2L1E|rcsb pdb:2L1H|rcsb pdb:2L1K|rcsb pdb:2L39|rcsb pdb:2L40|rcsb pdb:3NVG|rcsb pdb:3NVH|rcsb pdb:4H88|rcsb pdb:4J8R|rcsb pdb:4MA7|rcsb pdb:4MA8|rcsb pdb:6AQ7|rcsb pdb:6HER|rcsb pdb:6HHD|reactome:R-MMU-9609523|mint:MINT-7312150(identity)	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695|mint:MINT-7312145(identity)	-	-	-	figure legend:f6|comment:homomint|comment:domino|comment:mint|curation depth:mimix curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/12/04	2014/10/16	rogid:TRLrkh8lISmZdE7v3kEBmlkunmo10090	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	intact-crc:42625C5120729CBB|rigid:3Syfv9OwGiBFxBo5svW03X7YEuE	false	binding-associated region:100-109(MINT-7312151)	binding-associated region:156-215(MINT-7312146)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)