#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P25843 uniprotkb:Q24306 intact:EBI-156199|uniprotkb:Q3YMV6|uniprotkb:Q9VMJ9|ensemblmetazoa:FBpp0078864|ensemblmetazoa:FBpp0078865|ensemblmetazoa:FBpp0078866|ensemblmetazoa:FBpp0089196|ensemblmetazoa:FBpp0301151|ensemblmetazoa:FBpp0301152 intact:EBI-456419|uniprotkb:A4V1Z9|uniprotkb:Q0E8E4|uniprotkb:Q8MRM5|uniprotkb:Q9VUX5|uniprotkb:A9UN33|ensemblmetazoa:FBpp0075254|ensemblmetazoa:FBpp0075255|ensemblmetazoa:FBpp0075256|ensemblmetazoa:FBpp0305793|ensemblmetazoa:FBpp0305794|ensemblmetazoa:FBpp0305795 psi-mi:prof_drome(display_long)|uniprotkb:chic(gene name)|psi-mi:chic(display_short)|uniprotkb:chi(gene name synonym)|uniprotkb:CG9553(orf name)|uniprotkb:Protein chickadee(gene name synonym) psi-mi:diap1_drome(display_long)|uniprotkb:Diap1(gene name)|psi-mi:Diap1(display_short)|uniprotkb:Apoptosis 1 inhibitor(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase th(gene name synonym)|uniprotkb:Iap1(gene name synonym)|uniprotkb:Inhibitor of apoptosis 1(gene name synonym)|uniprotkb:Protein thread(gene name synonym)|uniprotkb:th(gene name synonym)|uniprotkb:CG12284(orf name)|uniprotkb:RING-type E3 ubiquitin transferase Diap1(gene name synonym) psi-mi:"MI:0096"(pull down) Geisbrecht et al. (2004) pubmed:15242648|imex:IM-20284 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2296718|imex:IM-20284-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001245905.1|refseq:NP_001245906.1|go:"GO:0043005"(neuron projection)|go:"GO:0045451"(pole plasm oskar mRNA localization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0051491"(positive regulation of filopodium assembly)|interpro:IPR005455(Profilin, plant)|interpro:IPR027310|interpro:IPR036140|refseq:NP_477016.1|refseq:NP_599131.1|refseq:NP_723136.1|refseq:NP_995635.1|flybase:FBgn0000308|ensemblmetazoa:FBgn0000308(gene)|ensemblmetazoa:FBtr0079233(transcript)|ensemblmetazoa:FBtr0079234(transcript)|ensemblmetazoa:FBtr0079235(transcript)|ensemblmetazoa:FBtr0079236(transcript)|ensemblmetazoa:FBtr0309212(transcript)|ensemblmetazoa:FBtr0309213(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000915"(actomyosin contractile ring assembly)|go:"GO:0003785"(actin monomer binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005938"(cell cortex)|go:"GO:0007015"(actin filament organization)|go:"GO:0007300"(ovarian nurse cell to oocyte transport)|go:"GO:0007391"(dorsal closure)|go:"GO:0007420"(brain development)|go:"GO:0007436"(larval salivary gland morphogenesis)|go:"GO:0007488"(histoblast morphogenesis)|go:"GO:0016322"(neuron remodeling)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030717"(oocyte karyosome formation)|go:"GO:0032507"(maintenance of protein location in cell)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035193"(larval central nervous system remodeling)|go:"GO:0036098"(male germ-line stem cell population maintenance)|go:"GO:0042060"(wound healing)|go:"GO:0042989"(sequestering of actin monomers)|dip:DIP-22165N refseq:NP_524101.2|refseq:NP_730097.1|refseq:NP_730098.1|flybase:FBgn0260635|refseq:NP_001261916.1|refseq:NP_001261917.1|refseq:NP_001261918.1|go:"GO:0006915"(apoptotic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007289"(spermatid nucleus differentiation)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0022416"(chaeta development)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044390"(ubiquitin-like protein conjugating enzyme binding)|go:"GO:0045035"(sensory organ precursor cell division)|go:"GO:0045116"(protein neddylation)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046673"(negative regulation of compound eye retinal cell programmed cell death)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048800"(antennal morphogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061663"(NEDD8 ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0089720"(caspase binding)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097340"(inhibition of cysteine-type endopeptidase activity)|go:"GO:1903688"(positive regulation of border follicle cell migration)|go:"GO:1990001"(inhibition of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:2001271"(negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|ensemblmetazoa:FBgn0260635(gene)|ensemblmetazoa:FBtr0075499(transcript)|ensemblmetazoa:FBtr0075500(transcript)|ensemblmetazoa:FBtr0075501(transcript)|ensemblmetazoa:FBtr0333617(transcript)|ensemblmetazoa:FBtr0333618(transcript)|ensemblmetazoa:FBtr0333619(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|mint:Q24306|rcsb pdb:1JD4|rcsb pdb:1JD5|rcsb pdb:1JD6|rcsb pdb:1Q4Q|rcsb pdb:1SDZ|rcsb pdb:1SE0|rcsb pdb:3SIP|rcsb pdb:3SIQ|reactome:R-DME-111465|reactome:R-DME-111469|reactome:R-DME-3769402|reactome:R-DME-390150|reactome:R-DME-5675482|reactome:R-DME-8948747|reactome:R-DME-8948751 - - - figure legend:6B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/03/30 2014/10/16 rogid:ixw/iYa5+5l7H5opccmsaYQvuY87227 rogid:loBQ//cKQ1NYhq3gnIKwRBn5vZg7227 intact-crc:B85CBC6BC2CBEBC4|rigid:Gc5BhofLlPFSs+j5pnn+vxgRB88 false - glutathione s tranferase tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P25843 uniprotkb:P40792 intact:EBI-156199|uniprotkb:Q3YMV6|uniprotkb:Q9VMJ9|ensemblmetazoa:FBpp0078864|ensemblmetazoa:FBpp0078865|ensemblmetazoa:FBpp0078866|ensemblmetazoa:FBpp0089196|ensemblmetazoa:FBpp0301151|ensemblmetazoa:FBpp0301152 intact:EBI-74845|uniprotkb:Q9W0H7|ensemblmetazoa:FBpp0072614|ensemblmetazoa:FBpp0304252 psi-mi:prof_drome(display_long)|uniprotkb:chic(gene name)|psi-mi:chic(display_short)|uniprotkb:chi(gene name synonym)|uniprotkb:CG9553(orf name)|uniprotkb:Protein chickadee(gene name synonym) psi-mi:rac1_drome(display_long)|uniprotkb:Rac1(gene name)|psi-mi:Rac1(display_short)|uniprotkb:RacA(gene name synonym)|uniprotkb:CG2248(orf name) psi-mi:"MI:0096"(pull down) Geisbrecht et al. (2004) pubmed:15242648|imex:IM-20284 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2296729|imex:IM-20284-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001245905.1|refseq:NP_001245906.1|go:"GO:0043005"(neuron projection)|go:"GO:0045451"(pole plasm oskar mRNA localization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0051491"(positive regulation of filopodium assembly)|interpro:IPR005455(Profilin, plant)|interpro:IPR027310|interpro:IPR036140|refseq:NP_477016.1|refseq:NP_599131.1|refseq:NP_723136.1|refseq:NP_995635.1|flybase:FBgn0000308|ensemblmetazoa:FBgn0000308(gene)|ensemblmetazoa:FBtr0079233(transcript)|ensemblmetazoa:FBtr0079234(transcript)|ensemblmetazoa:FBtr0079235(transcript)|ensemblmetazoa:FBtr0079236(transcript)|ensemblmetazoa:FBtr0309212(transcript)|ensemblmetazoa:FBtr0309213(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000915"(actomyosin contractile ring assembly)|go:"GO:0003785"(actin monomer binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005938"(cell cortex)|go:"GO:0007015"(actin filament organization)|go:"GO:0007300"(ovarian nurse cell to oocyte transport)|go:"GO:0007391"(dorsal closure)|go:"GO:0007420"(brain development)|go:"GO:0007436"(larval salivary gland morphogenesis)|go:"GO:0007488"(histoblast morphogenesis)|go:"GO:0016322"(neuron remodeling)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030717"(oocyte karyosome formation)|go:"GO:0032507"(maintenance of protein location in cell)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035193"(larval central nervous system remodeling)|go:"GO:0036098"(male germ-line stem cell population maintenance)|go:"GO:0042060"(wound healing)|go:"GO:0042989"(sequestering of actin monomers)|dip:DIP-22165N refseq:NP_476950.1|flybase:FBgn0010333|refseq:NP_001261247.1|ensemblmetazoa:FBgn0010333(gene)|ensemblmetazoa:FBtr0072730(transcript)|ensemblmetazoa:FBtr0331868(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002433"(immune response-regulating cell surface receptor signaling pathway involved in phagocytosis)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007254"(JNK cascade)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007390"(germ-band shortening)|go:"GO:0007391"(dorsal closure)|go:"GO:0007394"(dorsal closure, elongation of leading edge cells)|go:"GO:0007395"(dorsal closure, spreading of leading edge cells)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007419"(ventral cord development)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007426"(tracheal outgrowth, open tracheal system)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007516"(hemocyte development)|go:"GO:0007520"(myoblast fusion)|go:"GO:0007613"(memory)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008078"(mesodermal cell migration)|go:"GO:0008258"(head involution)|go:"GO:0008347"(glial cell migration)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009611"(response to wounding)|go:"GO:0010593"(negative regulation of lamellipodium assembly)|go:"GO:0016028"(rhabdomere)|go:"GO:0016199"(axon midline choice point recognition)|go:"GO:0016203"(muscle attachment)|go:"GO:0016358"(dendrite development)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035010"(encapsulation of foreign target)|go:"GO:0035011"(melanotic encapsulation of foreign target)|go:"GO:0035099"(hemocyte migration)|go:"GO:0035212"(cell competition in a multicellular organism)|go:"GO:0035320"(imaginal disc-derived wing hair site selection)|go:"GO:0042052"(rhabdomere development)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046664"(dorsal closure, amnioserosa morphology change)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048615"("embryonic anterior midgut (ectodermal) morphogenesis")|go:"GO:0048675"(axon extension)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050975"(sensory perception of touch)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051450"(myoblast proliferation)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055001"(muscle cell development)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0071907"(determination of digestive tract left/right asymmetry)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097206"(nephrocyte filtration)|go:"GO:0110125"(negative regulation of myotube cell migration)|go:"GO:1902669"(positive regulation of axon guidance)|go:"GO:1903391"(regulation of adherens junction organization)|go:"GO:1903688"(positive regulation of border follicle cell migration)|go:"GO:1904059"(regulation of locomotor rhythm)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|reactome:R-DME-114604|reactome:R-DME-1433557|reactome:R-DME-193648|reactome:R-DME-2029482|reactome:R-DME-2871796|reactome:R-DME-350376|reactome:R-DME-376172|reactome:R-DME-389359|reactome:R-DME-3928662|reactome:R-DME-3928664|reactome:R-DME-3928665|reactome:R-DME-399954|reactome:R-DME-4086400|reactome:R-DME-4420097|reactome:R-DME-445144|reactome:R-DME-5218920|reactome:R-DME-5625740|reactome:R-DME-5627123|reactome:R-DME-5663213|reactome:R-DME-5687128|reactome:R-DME-6798695|reactome:R-DME-8849471|reactome:R-DME-9013149|reactome:R-DME-9013404|reactome:R-DME-9013407|reactome:R-DME-9706019|reactome:R-DME-983231 - - - figure legend:6B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/03/30 2014/10/16 rogid:ixw/iYa5+5l7H5opccmsaYQvuY87227 rogid:nVrsdRuWmYjJp67rd4Es0mFDuUU7227 intact-crc:6ACC4543E9B8B1F9|rigid:bxazbLJ537f0S7uA8I+cLUb5cVM false - glutathione s tranferase tag:?-?|mutation:12-12|mutation:17-17 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P40792 uniprotkb:Q24306 intact:EBI-74845|uniprotkb:Q9W0H7|ensemblmetazoa:FBpp0072614|ensemblmetazoa:FBpp0304252 intact:EBI-456419|uniprotkb:A4V1Z9|uniprotkb:Q0E8E4|uniprotkb:Q8MRM5|uniprotkb:Q9VUX5|uniprotkb:A9UN33|ensemblmetazoa:FBpp0075254|ensemblmetazoa:FBpp0075255|ensemblmetazoa:FBpp0075256|ensemblmetazoa:FBpp0305793|ensemblmetazoa:FBpp0305794|ensemblmetazoa:FBpp0305795 psi-mi:rac1_drome(display_long)|uniprotkb:Rac1(gene name)|psi-mi:Rac1(display_short)|uniprotkb:RacA(gene name synonym)|uniprotkb:CG2248(orf name) psi-mi:diap1_drome(display_long)|uniprotkb:Diap1(gene name)|psi-mi:Diap1(display_short)|uniprotkb:Apoptosis 1 inhibitor(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase th(gene name synonym)|uniprotkb:Iap1(gene name synonym)|uniprotkb:Inhibitor of apoptosis 1(gene name synonym)|uniprotkb:Protein thread(gene name synonym)|uniprotkb:th(gene name synonym)|uniprotkb:CG12284(orf name)|uniprotkb:RING-type E3 ubiquitin transferase Diap1(gene name synonym) psi-mi:"MI:0096"(pull down) Geisbrecht et al. (2004) pubmed:15242648|imex:IM-20284 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2296707|imex:IM-20284-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_476950.1|flybase:FBgn0010333|refseq:NP_001261247.1|ensemblmetazoa:FBgn0010333(gene)|ensemblmetazoa:FBtr0072730(transcript)|ensemblmetazoa:FBtr0331868(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002433"(immune response-regulating cell surface receptor signaling pathway involved in phagocytosis)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007254"(JNK cascade)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007390"(germ-band shortening)|go:"GO:0007391"(dorsal closure)|go:"GO:0007394"(dorsal closure, elongation of leading edge cells)|go:"GO:0007395"(dorsal closure, spreading of leading edge cells)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007419"(ventral cord development)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007426"(tracheal outgrowth, open tracheal system)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007516"(hemocyte development)|go:"GO:0007520"(myoblast fusion)|go:"GO:0007613"(memory)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008078"(mesodermal cell migration)|go:"GO:0008258"(head involution)|go:"GO:0008347"(glial cell migration)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009611"(response to wounding)|go:"GO:0010593"(negative regulation of lamellipodium assembly)|go:"GO:0016028"(rhabdomere)|go:"GO:0016199"(axon midline choice point recognition)|go:"GO:0016203"(muscle attachment)|go:"GO:0016358"(dendrite development)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035010"(encapsulation of foreign target)|go:"GO:0035011"(melanotic encapsulation of foreign target)|go:"GO:0035099"(hemocyte migration)|go:"GO:0035212"(cell competition in a multicellular organism)|go:"GO:0035320"(imaginal disc-derived wing hair site selection)|go:"GO:0042052"(rhabdomere development)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046664"(dorsal closure, amnioserosa morphology change)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048615"("embryonic anterior midgut (ectodermal) morphogenesis")|go:"GO:0048675"(axon extension)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050975"(sensory perception of touch)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051450"(myoblast proliferation)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055001"(muscle cell development)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0071907"(determination of digestive tract left/right asymmetry)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097206"(nephrocyte filtration)|go:"GO:0110125"(negative regulation of myotube cell migration)|go:"GO:1902669"(positive regulation of axon guidance)|go:"GO:1903391"(regulation of adherens junction organization)|go:"GO:1903688"(positive regulation of border follicle cell migration)|go:"GO:1904059"(regulation of locomotor rhythm)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|reactome:R-DME-114604|reactome:R-DME-1433557|reactome:R-DME-193648|reactome:R-DME-2029482|reactome:R-DME-2871796|reactome:R-DME-350376|reactome:R-DME-376172|reactome:R-DME-389359|reactome:R-DME-3928662|reactome:R-DME-3928664|reactome:R-DME-3928665|reactome:R-DME-399954|reactome:R-DME-4086400|reactome:R-DME-4420097|reactome:R-DME-445144|reactome:R-DME-5218920|reactome:R-DME-5625740|reactome:R-DME-5627123|reactome:R-DME-5663213|reactome:R-DME-5687128|reactome:R-DME-6798695|reactome:R-DME-8849471|reactome:R-DME-9013149|reactome:R-DME-9013404|reactome:R-DME-9013407|reactome:R-DME-9706019|reactome:R-DME-983231 refseq:NP_524101.2|refseq:NP_730097.1|refseq:NP_730098.1|flybase:FBgn0260635|refseq:NP_001261916.1|refseq:NP_001261917.1|refseq:NP_001261918.1|go:"GO:0006915"(apoptotic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007289"(spermatid nucleus differentiation)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0022416"(chaeta development)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044390"(ubiquitin-like protein conjugating enzyme binding)|go:"GO:0045035"(sensory organ precursor cell division)|go:"GO:0045116"(protein neddylation)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046673"(negative regulation of compound eye retinal cell programmed cell death)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048800"(antennal morphogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061663"(NEDD8 ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0089720"(caspase binding)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097340"(inhibition of cysteine-type endopeptidase activity)|go:"GO:1903688"(positive regulation of border follicle cell migration)|go:"GO:1990001"(inhibition of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:2001271"(negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|ensemblmetazoa:FBgn0260635(gene)|ensemblmetazoa:FBtr0075499(transcript)|ensemblmetazoa:FBtr0075500(transcript)|ensemblmetazoa:FBtr0075501(transcript)|ensemblmetazoa:FBtr0333617(transcript)|ensemblmetazoa:FBtr0333618(transcript)|ensemblmetazoa:FBtr0333619(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|mint:Q24306|rcsb pdb:1JD4|rcsb pdb:1JD5|rcsb pdb:1JD6|rcsb pdb:1Q4Q|rcsb pdb:1SDZ|rcsb pdb:1SE0|rcsb pdb:3SIP|rcsb pdb:3SIQ|reactome:R-DME-111465|reactome:R-DME-111469|reactome:R-DME-3769402|reactome:R-DME-390150|reactome:R-DME-5675482|reactome:R-DME-8948747|reactome:R-DME-8948751 - - - figure legend:6F|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells) - 2009/03/30 2014/10/16 rogid:nVrsdRuWmYjJp67rd4Es0mFDuUU7227 rogid:loBQ//cKQ1NYhq3gnIKwRBn5vZg7227 intact-crc:BF6052B2F71314C5|rigid:wYJ3DnMXupL5/NjoUFL4hI7kgsE false v5 tag:?-?|mutation:12-12|mutation:17-17 glutathione s tranferase tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P40792 uniprotkb:P25843 intact:EBI-74845|uniprotkb:Q9W0H7|ensemblmetazoa:FBpp0072614|ensemblmetazoa:FBpp0304252 intact:EBI-156199|uniprotkb:Q3YMV6|uniprotkb:Q9VMJ9|ensemblmetazoa:FBpp0078864|ensemblmetazoa:FBpp0078865|ensemblmetazoa:FBpp0078866|ensemblmetazoa:FBpp0089196|ensemblmetazoa:FBpp0301151|ensemblmetazoa:FBpp0301152 psi-mi:rac1_drome(display_long)|uniprotkb:Rac1(gene name)|psi-mi:Rac1(display_short)|uniprotkb:RacA(gene name synonym)|uniprotkb:CG2248(orf name) psi-mi:prof_drome(display_long)|uniprotkb:chic(gene name)|psi-mi:chic(display_short)|uniprotkb:chi(gene name synonym)|uniprotkb:CG9553(orf name)|uniprotkb:Protein chickadee(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Geisbrecht et al. (2004) pubmed:15242648|imex:IM-20284 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2296783|imex:IM-20284-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_476950.1|flybase:FBgn0010333|refseq:NP_001261247.1|ensemblmetazoa:FBgn0010333(gene)|ensemblmetazoa:FBtr0072730(transcript)|ensemblmetazoa:FBtr0331868(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002433"(immune response-regulating cell surface receptor signaling pathway involved in phagocytosis)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007254"(JNK cascade)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007390"(germ-band shortening)|go:"GO:0007391"(dorsal closure)|go:"GO:0007394"(dorsal closure, elongation of leading edge cells)|go:"GO:0007395"(dorsal closure, spreading of leading edge cells)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007419"(ventral cord development)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007426"(tracheal outgrowth, open tracheal system)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007516"(hemocyte development)|go:"GO:0007520"(myoblast fusion)|go:"GO:0007613"(memory)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008078"(mesodermal cell migration)|go:"GO:0008258"(head involution)|go:"GO:0008347"(glial cell migration)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009611"(response to wounding)|go:"GO:0010593"(negative regulation of lamellipodium assembly)|go:"GO:0016028"(rhabdomere)|go:"GO:0016199"(axon midline choice point recognition)|go:"GO:0016203"(muscle attachment)|go:"GO:0016358"(dendrite development)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035010"(encapsulation of foreign target)|go:"GO:0035011"(melanotic encapsulation of foreign target)|go:"GO:0035099"(hemocyte migration)|go:"GO:0035212"(cell competition in a multicellular organism)|go:"GO:0035320"(imaginal disc-derived wing hair site selection)|go:"GO:0042052"(rhabdomere development)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046664"(dorsal closure, amnioserosa morphology change)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048615"("embryonic anterior midgut (ectodermal) morphogenesis")|go:"GO:0048675"(axon extension)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050975"(sensory perception of touch)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051450"(myoblast proliferation)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055001"(muscle cell development)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0071907"(determination of digestive tract left/right asymmetry)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097206"(nephrocyte filtration)|go:"GO:0110125"(negative regulation of myotube cell migration)|go:"GO:1902669"(positive regulation of axon guidance)|go:"GO:1903391"(regulation of adherens junction organization)|go:"GO:1903688"(positive regulation of border follicle cell migration)|go:"GO:1904059"(regulation of locomotor rhythm)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|reactome:R-DME-114604|reactome:R-DME-1433557|reactome:R-DME-193648|reactome:R-DME-2029482|reactome:R-DME-2871796|reactome:R-DME-350376|reactome:R-DME-376172|reactome:R-DME-389359|reactome:R-DME-3928662|reactome:R-DME-3928664|reactome:R-DME-3928665|reactome:R-DME-399954|reactome:R-DME-4086400|reactome:R-DME-4420097|reactome:R-DME-445144|reactome:R-DME-5218920|reactome:R-DME-5625740|reactome:R-DME-5627123|reactome:R-DME-5663213|reactome:R-DME-5687128|reactome:R-DME-6798695|reactome:R-DME-8849471|reactome:R-DME-9013149|reactome:R-DME-9013404|reactome:R-DME-9013407|reactome:R-DME-9706019|reactome:R-DME-983231 refseq:NP_001245905.1|refseq:NP_001245906.1|go:"GO:0043005"(neuron projection)|go:"GO:0045451"(pole plasm oskar mRNA localization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0051491"(positive regulation of filopodium assembly)|interpro:IPR005455(Profilin, plant)|interpro:IPR027310|interpro:IPR036140|refseq:NP_477016.1|refseq:NP_599131.1|refseq:NP_723136.1|refseq:NP_995635.1|flybase:FBgn0000308|ensemblmetazoa:FBgn0000308(gene)|ensemblmetazoa:FBtr0079233(transcript)|ensemblmetazoa:FBtr0079234(transcript)|ensemblmetazoa:FBtr0079235(transcript)|ensemblmetazoa:FBtr0079236(transcript)|ensemblmetazoa:FBtr0309212(transcript)|ensemblmetazoa:FBtr0309213(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000915"(actomyosin contractile ring assembly)|go:"GO:0003785"(actin monomer binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005938"(cell cortex)|go:"GO:0007015"(actin filament organization)|go:"GO:0007300"(ovarian nurse cell to oocyte transport)|go:"GO:0007391"(dorsal closure)|go:"GO:0007420"(brain development)|go:"GO:0007436"(larval salivary gland morphogenesis)|go:"GO:0007488"(histoblast morphogenesis)|go:"GO:0016322"(neuron remodeling)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030717"(oocyte karyosome formation)|go:"GO:0032507"(maintenance of protein location in cell)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035193"(larval central nervous system remodeling)|go:"GO:0036098"(male germ-line stem cell population maintenance)|go:"GO:0042060"(wound healing)|go:"GO:0042989"(sequestering of actin monomers)|dip:DIP-22165N - - - figure legend:6D|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells) - 2009/03/30 2014/10/16 rogid:nVrsdRuWmYjJp67rd4Es0mFDuUU7227 rogid:ixw/iYa5+5l7H5opccmsaYQvuY87227 intact-crc:9127EE9405023280|rigid:bxazbLJ537f0S7uA8I+cLUb5cVM false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P40792 uniprotkb:P25843 intact:EBI-74845|uniprotkb:Q9W0H7|ensemblmetazoa:FBpp0072614|ensemblmetazoa:FBpp0304252 intact:EBI-156199|uniprotkb:Q3YMV6|uniprotkb:Q9VMJ9|ensemblmetazoa:FBpp0078864|ensemblmetazoa:FBpp0078865|ensemblmetazoa:FBpp0078866|ensemblmetazoa:FBpp0089196|ensemblmetazoa:FBpp0301151|ensemblmetazoa:FBpp0301152 psi-mi:rac1_drome(display_long)|uniprotkb:Rac1(gene name)|psi-mi:Rac1(display_short)|uniprotkb:RacA(gene name synonym)|uniprotkb:CG2248(orf name) psi-mi:prof_drome(display_long)|uniprotkb:chic(gene name)|psi-mi:chic(display_short)|uniprotkb:chi(gene name synonym)|uniprotkb:CG9553(orf name)|uniprotkb:Protein chickadee(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Geisbrecht et al. (2004) pubmed:15242648|imex:IM-20284 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2296787|imex:IM-20284-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_476950.1|flybase:FBgn0010333|refseq:NP_001261247.1|ensemblmetazoa:FBgn0010333(gene)|ensemblmetazoa:FBtr0072730(transcript)|ensemblmetazoa:FBtr0331868(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002433"(immune response-regulating cell surface receptor signaling pathway involved in phagocytosis)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007254"(JNK cascade)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007390"(germ-band shortening)|go:"GO:0007391"(dorsal closure)|go:"GO:0007394"(dorsal closure, elongation of leading edge cells)|go:"GO:0007395"(dorsal closure, spreading of leading edge cells)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007419"(ventral cord development)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007426"(tracheal outgrowth, open tracheal system)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007516"(hemocyte development)|go:"GO:0007520"(myoblast fusion)|go:"GO:0007613"(memory)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008078"(mesodermal cell migration)|go:"GO:0008258"(head involution)|go:"GO:0008347"(glial cell migration)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009611"(response to wounding)|go:"GO:0010593"(negative regulation of lamellipodium assembly)|go:"GO:0016028"(rhabdomere)|go:"GO:0016199"(axon midline choice point recognition)|go:"GO:0016203"(muscle attachment)|go:"GO:0016358"(dendrite development)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035010"(encapsulation of foreign target)|go:"GO:0035011"(melanotic encapsulation of foreign target)|go:"GO:0035099"(hemocyte migration)|go:"GO:0035212"(cell competition in a multicellular organism)|go:"GO:0035320"(imaginal disc-derived wing hair site selection)|go:"GO:0042052"(rhabdomere development)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046664"(dorsal closure, amnioserosa morphology change)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048615"("embryonic anterior midgut (ectodermal) morphogenesis")|go:"GO:0048675"(axon extension)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050975"(sensory perception of touch)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051450"(myoblast proliferation)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055001"(muscle cell development)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0071907"(determination of digestive tract left/right asymmetry)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097206"(nephrocyte filtration)|go:"GO:0110125"(negative regulation of myotube cell migration)|go:"GO:1902669"(positive regulation of axon guidance)|go:"GO:1903391"(regulation of adherens junction organization)|go:"GO:1903688"(positive regulation of border follicle cell migration)|go:"GO:1904059"(regulation of locomotor rhythm)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|reactome:R-DME-114604|reactome:R-DME-1433557|reactome:R-DME-193648|reactome:R-DME-2029482|reactome:R-DME-2871796|reactome:R-DME-350376|reactome:R-DME-376172|reactome:R-DME-389359|reactome:R-DME-3928662|reactome:R-DME-3928664|reactome:R-DME-3928665|reactome:R-DME-399954|reactome:R-DME-4086400|reactome:R-DME-4420097|reactome:R-DME-445144|reactome:R-DME-5218920|reactome:R-DME-5625740|reactome:R-DME-5627123|reactome:R-DME-5663213|reactome:R-DME-5687128|reactome:R-DME-6798695|reactome:R-DME-8849471|reactome:R-DME-9013149|reactome:R-DME-9013404|reactome:R-DME-9013407|reactome:R-DME-9706019|reactome:R-DME-983231 refseq:NP_001245905.1|refseq:NP_001245906.1|go:"GO:0043005"(neuron projection)|go:"GO:0045451"(pole plasm oskar mRNA localization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0051491"(positive regulation of filopodium assembly)|interpro:IPR005455(Profilin, plant)|interpro:IPR027310|interpro:IPR036140|refseq:NP_477016.1|refseq:NP_599131.1|refseq:NP_723136.1|refseq:NP_995635.1|flybase:FBgn0000308|ensemblmetazoa:FBgn0000308(gene)|ensemblmetazoa:FBtr0079233(transcript)|ensemblmetazoa:FBtr0079234(transcript)|ensemblmetazoa:FBtr0079235(transcript)|ensemblmetazoa:FBtr0079236(transcript)|ensemblmetazoa:FBtr0309212(transcript)|ensemblmetazoa:FBtr0309213(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000915"(actomyosin contractile ring assembly)|go:"GO:0003785"(actin monomer binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005938"(cell cortex)|go:"GO:0007015"(actin filament organization)|go:"GO:0007300"(ovarian nurse cell to oocyte transport)|go:"GO:0007391"(dorsal closure)|go:"GO:0007420"(brain development)|go:"GO:0007436"(larval salivary gland morphogenesis)|go:"GO:0007488"(histoblast morphogenesis)|go:"GO:0016322"(neuron remodeling)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030717"(oocyte karyosome formation)|go:"GO:0032507"(maintenance of protein location in cell)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035193"(larval central nervous system remodeling)|go:"GO:0036098"(male germ-line stem cell population maintenance)|go:"GO:0042060"(wound healing)|go:"GO:0042989"(sequestering of actin monomers)|dip:DIP-22165N - - - figure legend:6C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells) - 2009/03/30 2014/10/16 rogid:nVrsdRuWmYjJp67rd4Es0mFDuUU7227 rogid:ixw/iYa5+5l7H5opccmsaYQvuY87227 intact-crc:6D4F9E3E0F483883|rigid:bxazbLJ537f0S7uA8I+cLUb5cVM false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q24306 uniprotkb:P25843 intact:EBI-456419|uniprotkb:A4V1Z9|uniprotkb:Q0E8E4|uniprotkb:Q8MRM5|uniprotkb:Q9VUX5|uniprotkb:A9UN33|ensemblmetazoa:FBpp0075254|ensemblmetazoa:FBpp0075255|ensemblmetazoa:FBpp0075256|ensemblmetazoa:FBpp0305793|ensemblmetazoa:FBpp0305794|ensemblmetazoa:FBpp0305795 intact:EBI-156199|uniprotkb:Q3YMV6|uniprotkb:Q9VMJ9|ensemblmetazoa:FBpp0078864|ensemblmetazoa:FBpp0078865|ensemblmetazoa:FBpp0078866|ensemblmetazoa:FBpp0089196|ensemblmetazoa:FBpp0301151|ensemblmetazoa:FBpp0301152 psi-mi:diap1_drome(display_long)|uniprotkb:Diap1(gene name)|psi-mi:Diap1(display_short)|uniprotkb:Apoptosis 1 inhibitor(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase th(gene name synonym)|uniprotkb:Iap1(gene name synonym)|uniprotkb:Inhibitor of apoptosis 1(gene name synonym)|uniprotkb:Protein thread(gene name synonym)|uniprotkb:th(gene name synonym)|uniprotkb:CG12284(orf name)|uniprotkb:RING-type E3 ubiquitin transferase Diap1(gene name synonym) psi-mi:prof_drome(display_long)|uniprotkb:chic(gene name)|psi-mi:chic(display_short)|uniprotkb:chi(gene name synonym)|uniprotkb:CG9553(orf name)|uniprotkb:Protein chickadee(gene name synonym) psi-mi:"MI:0096"(pull down) Geisbrecht et al. (2004) pubmed:15242648|imex:IM-20284 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2296757|imex:IM-20284-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_524101.2|refseq:NP_730097.1|refseq:NP_730098.1|flybase:FBgn0260635|refseq:NP_001261916.1|refseq:NP_001261917.1|refseq:NP_001261918.1|go:"GO:0006915"(apoptotic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007289"(spermatid nucleus differentiation)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0022416"(chaeta development)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044390"(ubiquitin-like protein conjugating enzyme binding)|go:"GO:0045035"(sensory organ precursor cell division)|go:"GO:0045116"(protein neddylation)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046673"(negative regulation of compound eye retinal cell programmed cell death)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048800"(antennal morphogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061663"(NEDD8 ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0089720"(caspase binding)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097340"(inhibition of cysteine-type endopeptidase activity)|go:"GO:1903688"(positive regulation of border follicle cell migration)|go:"GO:1990001"(inhibition of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:2001271"(negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|ensemblmetazoa:FBgn0260635(gene)|ensemblmetazoa:FBtr0075499(transcript)|ensemblmetazoa:FBtr0075500(transcript)|ensemblmetazoa:FBtr0075501(transcript)|ensemblmetazoa:FBtr0333617(transcript)|ensemblmetazoa:FBtr0333618(transcript)|ensemblmetazoa:FBtr0333619(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|mint:Q24306|rcsb pdb:1JD4|rcsb pdb:1JD5|rcsb pdb:1JD6|rcsb pdb:1Q4Q|rcsb pdb:1SDZ|rcsb pdb:1SE0|rcsb pdb:3SIP|rcsb pdb:3SIQ|reactome:R-DME-111465|reactome:R-DME-111469|reactome:R-DME-3769402|reactome:R-DME-390150|reactome:R-DME-5675482|reactome:R-DME-8948747|reactome:R-DME-8948751 refseq:NP_001245905.1|refseq:NP_001245906.1|go:"GO:0043005"(neuron projection)|go:"GO:0045451"(pole plasm oskar mRNA localization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0051491"(positive regulation of filopodium assembly)|interpro:IPR005455(Profilin, plant)|interpro:IPR027310|interpro:IPR036140|refseq:NP_477016.1|refseq:NP_599131.1|refseq:NP_723136.1|refseq:NP_995635.1|flybase:FBgn0000308|ensemblmetazoa:FBgn0000308(gene)|ensemblmetazoa:FBtr0079233(transcript)|ensemblmetazoa:FBtr0079234(transcript)|ensemblmetazoa:FBtr0079235(transcript)|ensemblmetazoa:FBtr0079236(transcript)|ensemblmetazoa:FBtr0309212(transcript)|ensemblmetazoa:FBtr0309213(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000915"(actomyosin contractile ring assembly)|go:"GO:0003785"(actin monomer binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005938"(cell cortex)|go:"GO:0007015"(actin filament organization)|go:"GO:0007300"(ovarian nurse cell to oocyte transport)|go:"GO:0007391"(dorsal closure)|go:"GO:0007420"(brain development)|go:"GO:0007436"(larval salivary gland morphogenesis)|go:"GO:0007488"(histoblast morphogenesis)|go:"GO:0016322"(neuron remodeling)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030717"(oocyte karyosome formation)|go:"GO:0032507"(maintenance of protein location in cell)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035193"(larval central nervous system remodeling)|go:"GO:0036098"(male germ-line stem cell population maintenance)|go:"GO:0042060"(wound healing)|go:"GO:0042989"(sequestering of actin monomers)|dip:DIP-22165N - - - figure legend:6E|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells) - 2009/03/30 2014/10/16 rogid:loBQ//cKQ1NYhq3gnIKwRBn5vZg7227 rogid:ixw/iYa5+5l7H5opccmsaYQvuY87227 intact-crc:55D0538A82D93301|rigid:Gc5BhofLlPFSs+j5pnn+vxgRB88 false glutathione s tranferase tag:?-? v5 tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)