#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9Y1J3	uniprotkb:Q17941	intact:EBI-323772|uniprotkb:Q9UA36|ensemblmetazoa:H42K12.1b.1	intact:EBI-1770718|uniprotkb:Q17942|uniprotkb:Q8MQE0|ensemblmetazoa:C12D8.10a.1|ensemblmetazoa:C12D8.10a.2	psi-mi:pdpk1_caeel(display_long)|uniprotkb:pdk-1(gene name)|psi-mi:pdk-1(display_short)|uniprotkb:H42K12.1(orf name)|uniprotkb:Pdk-class protein kinase 1(gene name synonym)	psi-mi:akt1_caeel(display_long)|uniprotkb:akt-1(gene name)|psi-mi:akt-1(display_short)|uniprotkb:C12D8.10(orf name)|uniprotkb:Protein kinase B akt-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hertweck et al. (2004)	pubmed:15068796|imex:IM-20341	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2429286|imex:IM-20341-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001024742.1|refseq:NP_001024743.1|wormbase:H42K12.1a|wormbase:H42K12.1b|ensemblmetazoa:H42K12.1b.1(transcript)|ensemblmetazoa:WBGene00003965(gene)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007611"(learning or memory)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040024"(dauer larval development)|go:"GO:0043025"(neuronal cell body)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR033931|interpro:IPR039046|dip:DIP-27322N	refseq:NP_001023645.1|refseq:NP_001023646.1|refseq:NP_001023647.1|wormbase:C12D8.10a|wormbase:C12D8.10b|wormbase:C12D8.10c|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017892|interpro:IPR001849(Pleckstrin-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR039026|mint:Q17941|ensemblmetazoa:C12D8.10a.1(transcript)|ensemblmetazoa:C12D8.10a.2(transcript)|ensemblmetazoa:WBGene00000102(gene)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0007635"(chemosensory behavior)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902074"(response to salt)|reactome:R-CEL-1257604|reactome:R-CEL-1474151|reactome:R-CEL-165158|reactome:R-CEL-165159|reactome:R-CEL-198323|reactome:R-CEL-198693|reactome:R-CEL-199418|reactome:R-CEL-203615|reactome:R-CEL-211163|reactome:R-CEL-389357|reactome:R-CEL-389513|reactome:R-CEL-392451|reactome:R-CEL-450385|reactome:R-CEL-450604|reactome:R-CEL-5218920|reactome:R-CEL-6811558|reactome:R-CEL-69202|reactome:R-CEL-69656|reactome:R-CEL-8849469|reactome:R-CEL-8876198|reactome:R-CEL-8948751|reactome:R-CEL-9009391|reactome:R-CEL-9604323|reactome:R-CEL-9607240|reactome:R-CEL-9614399|reactome:R-CEL-9634638	-	-	-	figure legend:Fig. 3B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/08/19	2014/10/16	rogid:Oec+kxqnvrzVmYzmEXV3tkYTp3o6239	rogid:Lbru/j15mbtFfQv0kZ3xFS+32Hs6239	intact-crc:AA4C874FD07773ED|rigid:G9brtfCcAh4efb2XBlLTlY8/VRc	false	35s radiolabel:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:O16850	uniprotkb:Q17941	intact:EBI-324028|uniprotkb:O16849|uniprotkb:O18676|uniprotkb:Q86S42|intact:EBI-1770827|uniprotkb:F3NWW7|uniprotkb:F3NWX0|uniprotkb:G4RQR7|uniprotkb:G4S686|uniprotkb:G4SKG3|uniprotkb:G4SKH0|ensemblmetazoa:R13H8.1h.1	intact:EBI-1770718|uniprotkb:Q17942|uniprotkb:Q8MQE0|ensemblmetazoa:C12D8.10a.1|ensemblmetazoa:C12D8.10a.2	psi-mi:foxo_caeel(display_long)|uniprotkb:Abnormal dauer formation protein 16(gene name synonym)|uniprotkb:daf-16(gene name)|psi-mi:daf-16(display_short)|uniprotkb:R13H8.1(orf name)	psi-mi:akt1_caeel(display_long)|uniprotkb:akt-1(gene name)|psi-mi:akt-1(display_short)|uniprotkb:C12D8.10(orf name)|uniprotkb:Protein kinase B akt-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hertweck et al. (2004)	pubmed:15068796|imex:IM-20341	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2429322|imex:IM-20341-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001021593.1|refseq:NP_001021594.1|refseq:NP_001021595.1|refseq:NP_001021597.1|wormbase:R13H8.1a|wormbase:R13H8.1b|wormbase:R13H8.1c|wormbase:R13H8.1e|refseq:NP_001021596.1|reactome:R-CEL-9607240|refseq:NP_001021598.2|refseq:NP_001251490.1|refseq:NP_001251492.1|reactome:R-CEL-9614399|reactome:R-CEL-9615017|reactome:R-CEL-9617629|wormbase:R13H8.1d|wormbase:R13H8.1f|wormbase:R13H8.1g|wormbase:R13H8.1h|ensemblmetazoa:R13H8.1h.1(transcript)|ensemblmetazoa:WBGene00000912(gene)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0002119"(nematode larval development)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0007614"(short-term memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0009411"(response to UV)|go:"GO:0010286"(heat acclimation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010564"(regulation of cell cycle process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0040024"(dauer larval development)|go:"GO:0042594"(response to starvation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043620"(regulation of DNA-templated transcription in response to stress)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046890"(regulation of lipid biosynthetic process)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060537"(muscle tissue development)|go:"GO:0061065"(regulation of dauer larval development)|go:"GO:0061066"(positive regulation of dauer larval development)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900075"(positive regulation of neuromuscular synaptic transmission)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1905909"(regulation of dauer entry)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|go:"GO:0045087"(innate immune response)|reactome:R-CEL-198693|reactome:R-CEL-211163|reactome:R-CEL-5687128|dip:DIP-25581N|reactome:R-CEL-5689880|reactome:R-CEL-1181150|reactome:R-CEL-9617828|reactome:R-CEL-9634638	refseq:NP_001023645.1|refseq:NP_001023646.1|refseq:NP_001023647.1|wormbase:C12D8.10a|wormbase:C12D8.10b|wormbase:C12D8.10c|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017892|interpro:IPR001849(Pleckstrin-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR039026|mint:Q17941|ensemblmetazoa:C12D8.10a.1(transcript)|ensemblmetazoa:C12D8.10a.2(transcript)|ensemblmetazoa:WBGene00000102(gene)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0007635"(chemosensory behavior)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902074"(response to salt)|reactome:R-CEL-1257604|reactome:R-CEL-1474151|reactome:R-CEL-165158|reactome:R-CEL-165159|reactome:R-CEL-198323|reactome:R-CEL-198693|reactome:R-CEL-199418|reactome:R-CEL-203615|reactome:R-CEL-211163|reactome:R-CEL-389357|reactome:R-CEL-389513|reactome:R-CEL-392451|reactome:R-CEL-450385|reactome:R-CEL-450604|reactome:R-CEL-5218920|reactome:R-CEL-6811558|reactome:R-CEL-69202|reactome:R-CEL-69656|reactome:R-CEL-8849469|reactome:R-CEL-8876198|reactome:R-CEL-8948751|reactome:R-CEL-9009391|reactome:R-CEL-9604323|reactome:R-CEL-9607240|reactome:R-CEL-9614399|reactome:R-CEL-9634638	-	-	-	figure legend:Fig. 3B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/08/19	2014/10/16	rogid:UfAMA8NPgcJv93n6XAjW5mLboZQ6239	rogid:Lbru/j15mbtFfQv0kZ3xFS+32Hs6239	intact-crc:0947F228972E6CC8|rigid:i9XRxd1yDYpUfFzltbHwudiZ2uo	false	35s radiolabel:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q17941	uniprotkb:Q2PJ68	intact:EBI-1770718|uniprotkb:Q17942|uniprotkb:Q8MQE0|ensemblmetazoa:C12D8.10a.1|ensemblmetazoa:C12D8.10a.2	intact:EBI-1770776|uniprotkb:Q2PJ69|ensemblmetazoa:W10G6.2b.1	psi-mi:akt1_caeel(display_long)|uniprotkb:akt-1(gene name)|psi-mi:akt-1(display_short)|uniprotkb:C12D8.10(orf name)|uniprotkb:Protein kinase B akt-1(gene name synonym)	psi-mi:sgk1_caeel(display_long)|uniprotkb:Serum/glucocorticoid-regulated kinase 1(gene name synonym)|uniprotkb:sgk-1(gene name)|psi-mi:sgk-1(display_short)|uniprotkb:W10G6.2(orf name)|uniprotkb:Serum- and glucocorticoid-inducible kinase homolog(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hertweck et al. (2004)	pubmed:15068796|imex:IM-20341	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2429330|imex:IM-20341-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001023645.1|refseq:NP_001023646.1|refseq:NP_001023647.1|wormbase:C12D8.10a|wormbase:C12D8.10b|wormbase:C12D8.10c|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017892|interpro:IPR001849(Pleckstrin-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR039026|mint:Q17941|ensemblmetazoa:C12D8.10a.1(transcript)|ensemblmetazoa:C12D8.10a.2(transcript)|ensemblmetazoa:WBGene00000102(gene)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0007635"(chemosensory behavior)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902074"(response to salt)|reactome:R-CEL-1257604|reactome:R-CEL-1474151|reactome:R-CEL-165158|reactome:R-CEL-165159|reactome:R-CEL-198323|reactome:R-CEL-198693|reactome:R-CEL-199418|reactome:R-CEL-203615|reactome:R-CEL-211163|reactome:R-CEL-389357|reactome:R-CEL-389513|reactome:R-CEL-392451|reactome:R-CEL-450385|reactome:R-CEL-450604|reactome:R-CEL-5218920|reactome:R-CEL-6811558|reactome:R-CEL-69202|reactome:R-CEL-69656|reactome:R-CEL-8849469|reactome:R-CEL-8876198|reactome:R-CEL-8948751|reactome:R-CEL-9009391|reactome:R-CEL-9604323|reactome:R-CEL-9607240|reactome:R-CEL-9614399|reactome:R-CEL-9634638	reactome:R-CEL-6804757|refseq:NP_001041298.1|refseq:NP_001041299.1|wormbase:W10G6.2a|wormbase:W10G6.2b|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|reactome:R-CEL-2672351|reactome:R-CEL-9031628|ensemblmetazoa:W10G6.2b.1(transcript)|ensemblmetazoa:WBGene00004789(gene)|go:"GO:0002119"(nematode larval development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0044255"(cellular lipid metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048382"(mesendoderm development)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903188"(positive regulation of vitellogenesis)|go:"GO:1904508"(regulation of protein localization to basolateral plasma membrane)	-	-	-	figure legend:Fig. 3B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/08/19	2014/10/16	rogid:Lbru/j15mbtFfQv0kZ3xFS+32Hs6239	rogid:ngczdO33Sry0fNHG63cFjKsegn46239	intact-crc:F455E50F43198ECF|rigid:Yq4CRwtqamJ+m9yslsP2c6nYjlw	false	glutathione s tranferase tag:?-?	35s radiolabel:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q9XTG7	uniprotkb:Q17941	intact:EBI-320656|uniprotkb:O77145|ensemblmetazoa:F28H6.1a.1	intact:EBI-1770718|uniprotkb:Q17942|uniprotkb:Q8MQE0|ensemblmetazoa:C12D8.10a.1|ensemblmetazoa:C12D8.10a.2	psi-mi:akt2_caeel(display_long)|uniprotkb:akt-2(gene name)|psi-mi:akt-2(display_short)|uniprotkb:Protein kinase B akt-2(gene name synonym)|uniprotkb:F28H6.1(orf name)	psi-mi:akt1_caeel(display_long)|uniprotkb:akt-1(gene name)|psi-mi:akt-1(display_short)|uniprotkb:C12D8.10(orf name)|uniprotkb:Protein kinase B akt-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hertweck et al. (2004)	pubmed:15068796|imex:IM-20341	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2429338|imex:IM-20341-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_510357.3|wormbase:F28H6.1a|wormbase:F28H6.1b|reactome:R-CEL-392451|refseq:NP_001024612.1|ensemblmetazoa:F28H6.1a.1(transcript)|ensemblmetazoa:WBGene00000103(gene)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR039026|go:"GO:0045087"(innate immune response)|reactome:R-CEL-165158|reactome:R-CEL-1257604|reactome:R-CEL-198323|reactome:R-CEL-198693|reactome:R-CEL-199418|reactome:R-CEL-389357|reactome:R-CEL-5218920|dip:DIP-26368N|reactome:R-CEL-9634638|reactome:R-CEL-211163|reactome:R-CEL-69202|reactome:R-CEL-69656|reactome:R-CEL-8876198|reactome:R-CEL-8948751|reactome:R-CEL-9614399|reactome:R-CEL-1474151|reactome:R-CEL-165159|reactome:R-CEL-203615|reactome:R-CEL-389513|reactome:R-CEL-450385|reactome:R-CEL-450604|reactome:R-CEL-6811558|reactome:R-CEL-8849469|reactome:R-CEL-9009391|reactome:R-CEL-9604323|reactome:R-CEL-9607240	refseq:NP_001023645.1|refseq:NP_001023646.1|refseq:NP_001023647.1|wormbase:C12D8.10a|wormbase:C12D8.10b|wormbase:C12D8.10c|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017892|interpro:IPR001849(Pleckstrin-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR039026|mint:Q17941|ensemblmetazoa:C12D8.10a.1(transcript)|ensemblmetazoa:C12D8.10a.2(transcript)|ensemblmetazoa:WBGene00000102(gene)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0007635"(chemosensory behavior)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902074"(response to salt)|reactome:R-CEL-1257604|reactome:R-CEL-1474151|reactome:R-CEL-165158|reactome:R-CEL-165159|reactome:R-CEL-198323|reactome:R-CEL-198693|reactome:R-CEL-199418|reactome:R-CEL-203615|reactome:R-CEL-211163|reactome:R-CEL-389357|reactome:R-CEL-389513|reactome:R-CEL-392451|reactome:R-CEL-450385|reactome:R-CEL-450604|reactome:R-CEL-5218920|reactome:R-CEL-6811558|reactome:R-CEL-69202|reactome:R-CEL-69656|reactome:R-CEL-8849469|reactome:R-CEL-8876198|reactome:R-CEL-8948751|reactome:R-CEL-9009391|reactome:R-CEL-9604323|reactome:R-CEL-9607240|reactome:R-CEL-9614399|reactome:R-CEL-9634638	-	-	-	figure legend:Fig. 3B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/08/19	2014/10/16	rogid:Y8D47LHcNyTK3JpkYGj9/UCRYKs6239	rogid:Lbru/j15mbtFfQv0kZ3xFS+32Hs6239	intact-crc:5CEFC7DFBEF044F8|rigid:nSPysngRzlJiK67nHbpZqrIdEVQ	false	35s radiolabel:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q9XTG7	uniprotkb:Q9Y1J3	intact:EBI-320656|uniprotkb:O77145|ensemblmetazoa:F28H6.1a.1	intact:EBI-323772|uniprotkb:Q9UA36|ensemblmetazoa:H42K12.1b.1	psi-mi:akt2_caeel(display_long)|uniprotkb:akt-2(gene name)|psi-mi:akt-2(display_short)|uniprotkb:Protein kinase B akt-2(gene name synonym)|uniprotkb:F28H6.1(orf name)	psi-mi:pdpk1_caeel(display_long)|uniprotkb:pdk-1(gene name)|psi-mi:pdk-1(display_short)|uniprotkb:H42K12.1(orf name)|uniprotkb:Pdk-class protein kinase 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hertweck et al. (2004)	pubmed:15068796|imex:IM-20341	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2429354|imex:IM-20341-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_510357.3|wormbase:F28H6.1a|wormbase:F28H6.1b|reactome:R-CEL-392451|refseq:NP_001024612.1|ensemblmetazoa:F28H6.1a.1(transcript)|ensemblmetazoa:WBGene00000103(gene)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR039026|go:"GO:0045087"(innate immune response)|reactome:R-CEL-165158|reactome:R-CEL-1257604|reactome:R-CEL-198323|reactome:R-CEL-198693|reactome:R-CEL-199418|reactome:R-CEL-389357|reactome:R-CEL-5218920|dip:DIP-26368N|reactome:R-CEL-9634638|reactome:R-CEL-211163|reactome:R-CEL-69202|reactome:R-CEL-69656|reactome:R-CEL-8876198|reactome:R-CEL-8948751|reactome:R-CEL-9614399|reactome:R-CEL-1474151|reactome:R-CEL-165159|reactome:R-CEL-203615|reactome:R-CEL-389513|reactome:R-CEL-450385|reactome:R-CEL-450604|reactome:R-CEL-6811558|reactome:R-CEL-8849469|reactome:R-CEL-9009391|reactome:R-CEL-9604323|reactome:R-CEL-9607240	refseq:NP_001024742.1|refseq:NP_001024743.1|wormbase:H42K12.1a|wormbase:H42K12.1b|ensemblmetazoa:H42K12.1b.1(transcript)|ensemblmetazoa:WBGene00003965(gene)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007611"(learning or memory)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040024"(dauer larval development)|go:"GO:0043025"(neuronal cell body)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR033931|interpro:IPR039046|dip:DIP-27322N	-	-	-	figure legend:Fig. 3B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/08/19	2014/10/16	rogid:Y8D47LHcNyTK3JpkYGj9/UCRYKs6239	rogid:Oec+kxqnvrzVmYzmEXV3tkYTp3o6239	intact-crc:C919242BC17C5DB9|rigid:x9Iv+InhCTSJng8CoSHh2qXQEnE	false	glutathione s tranferase tag:?-?	35s radiolabel:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:O16850	uniprotkb:Q9XTG7	intact:EBI-324028|uniprotkb:O16849|uniprotkb:O18676|uniprotkb:Q86S42|intact:EBI-1770827|uniprotkb:F3NWW7|uniprotkb:F3NWX0|uniprotkb:G4RQR7|uniprotkb:G4S686|uniprotkb:G4SKG3|uniprotkb:G4SKH0|ensemblmetazoa:R13H8.1h.1	intact:EBI-320656|uniprotkb:O77145|ensemblmetazoa:F28H6.1a.1	psi-mi:foxo_caeel(display_long)|uniprotkb:Abnormal dauer formation protein 16(gene name synonym)|uniprotkb:daf-16(gene name)|psi-mi:daf-16(display_short)|uniprotkb:R13H8.1(orf name)	psi-mi:akt2_caeel(display_long)|uniprotkb:akt-2(gene name)|psi-mi:akt-2(display_short)|uniprotkb:Protein kinase B akt-2(gene name synonym)|uniprotkb:F28H6.1(orf name)	psi-mi:"MI:0096"(pull down)	Hertweck et al. (2004)	pubmed:15068796|imex:IM-20341	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2429362|imex:IM-20341-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001021593.1|refseq:NP_001021594.1|refseq:NP_001021595.1|refseq:NP_001021597.1|wormbase:R13H8.1a|wormbase:R13H8.1b|wormbase:R13H8.1c|wormbase:R13H8.1e|refseq:NP_001021596.1|reactome:R-CEL-9607240|refseq:NP_001021598.2|refseq:NP_001251490.1|refseq:NP_001251492.1|reactome:R-CEL-9614399|reactome:R-CEL-9615017|reactome:R-CEL-9617629|wormbase:R13H8.1d|wormbase:R13H8.1f|wormbase:R13H8.1g|wormbase:R13H8.1h|ensemblmetazoa:R13H8.1h.1(transcript)|ensemblmetazoa:WBGene00000912(gene)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0002119"(nematode larval development)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0007614"(short-term memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0009411"(response to UV)|go:"GO:0010286"(heat acclimation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010564"(regulation of cell cycle process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0040024"(dauer larval development)|go:"GO:0042594"(response to starvation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043620"(regulation of DNA-templated transcription in response to stress)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046890"(regulation of lipid biosynthetic process)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060537"(muscle tissue development)|go:"GO:0061065"(regulation of dauer larval development)|go:"GO:0061066"(positive regulation of dauer larval development)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900075"(positive regulation of neuromuscular synaptic transmission)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1905909"(regulation of dauer entry)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|go:"GO:0045087"(innate immune response)|reactome:R-CEL-198693|reactome:R-CEL-211163|reactome:R-CEL-5687128|dip:DIP-25581N|reactome:R-CEL-5689880|reactome:R-CEL-1181150|reactome:R-CEL-9617828|reactome:R-CEL-9634638	refseq:NP_510357.3|wormbase:F28H6.1a|wormbase:F28H6.1b|reactome:R-CEL-392451|refseq:NP_001024612.1|ensemblmetazoa:F28H6.1a.1(transcript)|ensemblmetazoa:WBGene00000103(gene)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR039026|go:"GO:0045087"(innate immune response)|reactome:R-CEL-165158|reactome:R-CEL-1257604|reactome:R-CEL-198323|reactome:R-CEL-198693|reactome:R-CEL-199418|reactome:R-CEL-389357|reactome:R-CEL-5218920|dip:DIP-26368N|reactome:R-CEL-9634638|reactome:R-CEL-211163|reactome:R-CEL-69202|reactome:R-CEL-69656|reactome:R-CEL-8876198|reactome:R-CEL-8948751|reactome:R-CEL-9614399|reactome:R-CEL-1474151|reactome:R-CEL-165159|reactome:R-CEL-203615|reactome:R-CEL-389513|reactome:R-CEL-450385|reactome:R-CEL-450604|reactome:R-CEL-6811558|reactome:R-CEL-8849469|reactome:R-CEL-9009391|reactome:R-CEL-9604323|reactome:R-CEL-9607240	-	-	-	figure legend:Fig. 3B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/08/19	2014/10/16	rogid:UfAMA8NPgcJv93n6XAjW5mLboZQ6239	rogid:Y8D47LHcNyTK3JpkYGj9/UCRYKs6239	intact-crc:38645DA6038E7232|rigid:6Gay1LRzU1w7M7nm4AvpTN8r9+s	false	35s radiolabel:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q2PJ68	uniprotkb:Q9XTG7	intact:EBI-1770776|uniprotkb:Q2PJ69|ensemblmetazoa:W10G6.2b.1	intact:EBI-320656|uniprotkb:O77145|ensemblmetazoa:F28H6.1a.1	psi-mi:sgk1_caeel(display_long)|uniprotkb:Serum/glucocorticoid-regulated kinase 1(gene name synonym)|uniprotkb:sgk-1(gene name)|psi-mi:sgk-1(display_short)|uniprotkb:W10G6.2(orf name)|uniprotkb:Serum- and glucocorticoid-inducible kinase homolog(gene name synonym)	psi-mi:akt2_caeel(display_long)|uniprotkb:akt-2(gene name)|psi-mi:akt-2(display_short)|uniprotkb:Protein kinase B akt-2(gene name synonym)|uniprotkb:F28H6.1(orf name)	psi-mi:"MI:0096"(pull down)	Hertweck et al. (2004)	pubmed:15068796|imex:IM-20341	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2429370|imex:IM-20341-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-CEL-6804757|refseq:NP_001041298.1|refseq:NP_001041299.1|wormbase:W10G6.2a|wormbase:W10G6.2b|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|reactome:R-CEL-2672351|reactome:R-CEL-9031628|ensemblmetazoa:W10G6.2b.1(transcript)|ensemblmetazoa:WBGene00004789(gene)|go:"GO:0002119"(nematode larval development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0044255"(cellular lipid metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048382"(mesendoderm development)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903188"(positive regulation of vitellogenesis)|go:"GO:1904508"(regulation of protein localization to basolateral plasma membrane)	refseq:NP_510357.3|wormbase:F28H6.1a|wormbase:F28H6.1b|reactome:R-CEL-392451|refseq:NP_001024612.1|ensemblmetazoa:F28H6.1a.1(transcript)|ensemblmetazoa:WBGene00000103(gene)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR039026|go:"GO:0045087"(innate immune response)|reactome:R-CEL-165158|reactome:R-CEL-1257604|reactome:R-CEL-198323|reactome:R-CEL-198693|reactome:R-CEL-199418|reactome:R-CEL-389357|reactome:R-CEL-5218920|dip:DIP-26368N|reactome:R-CEL-9634638|reactome:R-CEL-211163|reactome:R-CEL-69202|reactome:R-CEL-69656|reactome:R-CEL-8876198|reactome:R-CEL-8948751|reactome:R-CEL-9614399|reactome:R-CEL-1474151|reactome:R-CEL-165159|reactome:R-CEL-203615|reactome:R-CEL-389513|reactome:R-CEL-450385|reactome:R-CEL-450604|reactome:R-CEL-6811558|reactome:R-CEL-8849469|reactome:R-CEL-9009391|reactome:R-CEL-9604323|reactome:R-CEL-9607240	-	-	-	figure legend:Fig. 3B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/08/19	2014/10/16	rogid:ngczdO33Sry0fNHG63cFjKsegn46239	rogid:Y8D47LHcNyTK3JpkYGj9/UCRYKs6239	intact-crc:CBB2F5B8466A1173|rigid:2EcdN3GyNSA0x8BtqpUZihITVAo	false	35s radiolabel:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q2PJ68	uniprotkb:Q9Y1J3	intact:EBI-1770776|uniprotkb:Q2PJ69|ensemblmetazoa:W10G6.2b.1	intact:EBI-323772|uniprotkb:Q9UA36|ensemblmetazoa:H42K12.1b.1	psi-mi:sgk1_caeel(display_long)|uniprotkb:Serum/glucocorticoid-regulated kinase 1(gene name synonym)|uniprotkb:sgk-1(gene name)|psi-mi:sgk-1(display_short)|uniprotkb:W10G6.2(orf name)|uniprotkb:Serum- and glucocorticoid-inducible kinase homolog(gene name synonym)	psi-mi:pdpk1_caeel(display_long)|uniprotkb:pdk-1(gene name)|psi-mi:pdk-1(display_short)|uniprotkb:H42K12.1(orf name)|uniprotkb:Pdk-class protein kinase 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hertweck et al. (2004)	pubmed:15068796|imex:IM-20341	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2429378|imex:IM-20341-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-CEL-6804757|refseq:NP_001041298.1|refseq:NP_001041299.1|wormbase:W10G6.2a|wormbase:W10G6.2b|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|reactome:R-CEL-2672351|reactome:R-CEL-9031628|ensemblmetazoa:W10G6.2b.1(transcript)|ensemblmetazoa:WBGene00004789(gene)|go:"GO:0002119"(nematode larval development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0044255"(cellular lipid metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048382"(mesendoderm development)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903188"(positive regulation of vitellogenesis)|go:"GO:1904508"(regulation of protein localization to basolateral plasma membrane)	refseq:NP_001024742.1|refseq:NP_001024743.1|wormbase:H42K12.1a|wormbase:H42K12.1b|ensemblmetazoa:H42K12.1b.1(transcript)|ensemblmetazoa:WBGene00003965(gene)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007611"(learning or memory)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040024"(dauer larval development)|go:"GO:0043025"(neuronal cell body)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR033931|interpro:IPR039046|dip:DIP-27322N	-	-	-	figure legend:Fig. 3B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/08/19	2014/10/16	rogid:ngczdO33Sry0fNHG63cFjKsegn46239	rogid:Oec+kxqnvrzVmYzmEXV3tkYTp3o6239	intact-crc:E32D5B7091A381E4|rigid:+52r8jSRWU6sGnr0DboXUYN1Tf8	false	glutathione s tranferase tag:?-?	35s radiolabel:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:O16850	uniprotkb:Q2PJ68	intact:EBI-324028|uniprotkb:O16849|uniprotkb:O18676|uniprotkb:Q86S42|intact:EBI-1770827|uniprotkb:F3NWW7|uniprotkb:F3NWX0|uniprotkb:G4RQR7|uniprotkb:G4S686|uniprotkb:G4SKG3|uniprotkb:G4SKH0|ensemblmetazoa:R13H8.1h.1	intact:EBI-1770776|uniprotkb:Q2PJ69|ensemblmetazoa:W10G6.2b.1	psi-mi:foxo_caeel(display_long)|uniprotkb:Abnormal dauer formation protein 16(gene name synonym)|uniprotkb:daf-16(gene name)|psi-mi:daf-16(display_short)|uniprotkb:R13H8.1(orf name)	psi-mi:sgk1_caeel(display_long)|uniprotkb:Serum/glucocorticoid-regulated kinase 1(gene name synonym)|uniprotkb:sgk-1(gene name)|psi-mi:sgk-1(display_short)|uniprotkb:W10G6.2(orf name)|uniprotkb:Serum- and glucocorticoid-inducible kinase homolog(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hertweck et al. (2004)	pubmed:15068796|imex:IM-20341	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2429386|imex:IM-20341-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001021593.1|refseq:NP_001021594.1|refseq:NP_001021595.1|refseq:NP_001021597.1|wormbase:R13H8.1a|wormbase:R13H8.1b|wormbase:R13H8.1c|wormbase:R13H8.1e|refseq:NP_001021596.1|reactome:R-CEL-9607240|refseq:NP_001021598.2|refseq:NP_001251490.1|refseq:NP_001251492.1|reactome:R-CEL-9614399|reactome:R-CEL-9615017|reactome:R-CEL-9617629|wormbase:R13H8.1d|wormbase:R13H8.1f|wormbase:R13H8.1g|wormbase:R13H8.1h|ensemblmetazoa:R13H8.1h.1(transcript)|ensemblmetazoa:WBGene00000912(gene)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0002119"(nematode larval development)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0007614"(short-term memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0009411"(response to UV)|go:"GO:0010286"(heat acclimation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010564"(regulation of cell cycle process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0040024"(dauer larval development)|go:"GO:0042594"(response to starvation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043620"(regulation of DNA-templated transcription in response to stress)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046890"(regulation of lipid biosynthetic process)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060537"(muscle tissue development)|go:"GO:0061065"(regulation of dauer larval development)|go:"GO:0061066"(positive regulation of dauer larval development)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900075"(positive regulation of neuromuscular synaptic transmission)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1905909"(regulation of dauer entry)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|go:"GO:0045087"(innate immune response)|reactome:R-CEL-198693|reactome:R-CEL-211163|reactome:R-CEL-5687128|dip:DIP-25581N|reactome:R-CEL-5689880|reactome:R-CEL-1181150|reactome:R-CEL-9617828|reactome:R-CEL-9634638	reactome:R-CEL-6804757|refseq:NP_001041298.1|refseq:NP_001041299.1|wormbase:W10G6.2a|wormbase:W10G6.2b|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|reactome:R-CEL-2672351|reactome:R-CEL-9031628|ensemblmetazoa:W10G6.2b.1(transcript)|ensemblmetazoa:WBGene00004789(gene)|go:"GO:0002119"(nematode larval development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0044255"(cellular lipid metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048382"(mesendoderm development)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903188"(positive regulation of vitellogenesis)|go:"GO:1904508"(regulation of protein localization to basolateral plasma membrane)	-	-	-	figure legend:Fig. 3B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/08/19	2014/10/16	rogid:UfAMA8NPgcJv93n6XAjW5mLboZQ6239	rogid:ngczdO33Sry0fNHG63cFjKsegn46239	intact-crc:11356DE709D02A37|rigid:21e4TpoNrajtb1ZnWT35+afA0yU	false	35s radiolabel:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q2PJ68	uniprotkb:Q17941	intact:EBI-1770776|uniprotkb:Q2PJ69|ensemblmetazoa:W10G6.2b.1	intact:EBI-1770718|uniprotkb:Q17942|uniprotkb:Q8MQE0|ensemblmetazoa:C12D8.10a.1|ensemblmetazoa:C12D8.10a.2	psi-mi:sgk1_caeel(display_long)|uniprotkb:Serum/glucocorticoid-regulated kinase 1(gene name synonym)|uniprotkb:sgk-1(gene name)|psi-mi:sgk-1(display_short)|uniprotkb:W10G6.2(orf name)|uniprotkb:Serum- and glucocorticoid-inducible kinase homolog(gene name synonym)	psi-mi:akt1_caeel(display_long)|uniprotkb:akt-1(gene name)|psi-mi:akt-1(display_short)|uniprotkb:C12D8.10(orf name)|uniprotkb:Protein kinase B akt-1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Hertweck et al. (2004)	pubmed:15068796|imex:IM-20341	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2429400|imex:IM-20341-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-CEL-6804757|refseq:NP_001041298.1|refseq:NP_001041299.1|wormbase:W10G6.2a|wormbase:W10G6.2b|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|reactome:R-CEL-2672351|reactome:R-CEL-9031628|ensemblmetazoa:W10G6.2b.1(transcript)|ensemblmetazoa:WBGene00004789(gene)|go:"GO:0002119"(nematode larval development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0044255"(cellular lipid metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048382"(mesendoderm development)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903188"(positive regulation of vitellogenesis)|go:"GO:1904508"(regulation of protein localization to basolateral plasma membrane)	refseq:NP_001023645.1|refseq:NP_001023646.1|refseq:NP_001023647.1|wormbase:C12D8.10a|wormbase:C12D8.10b|wormbase:C12D8.10c|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017892|interpro:IPR001849(Pleckstrin-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR039026|mint:Q17941|ensemblmetazoa:C12D8.10a.1(transcript)|ensemblmetazoa:C12D8.10a.2(transcript)|ensemblmetazoa:WBGene00000102(gene)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0007635"(chemosensory behavior)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902074"(response to salt)|reactome:R-CEL-1257604|reactome:R-CEL-1474151|reactome:R-CEL-165158|reactome:R-CEL-165159|reactome:R-CEL-198323|reactome:R-CEL-198693|reactome:R-CEL-199418|reactome:R-CEL-203615|reactome:R-CEL-211163|reactome:R-CEL-389357|reactome:R-CEL-389513|reactome:R-CEL-392451|reactome:R-CEL-450385|reactome:R-CEL-450604|reactome:R-CEL-5218920|reactome:R-CEL-6811558|reactome:R-CEL-69202|reactome:R-CEL-69656|reactome:R-CEL-8849469|reactome:R-CEL-8876198|reactome:R-CEL-8948751|reactome:R-CEL-9009391|reactome:R-CEL-9604323|reactome:R-CEL-9607240|reactome:R-CEL-9614399|reactome:R-CEL-9634638	-	-	-	figure legend:Fig. 3C|caution:Constructs lacking kinase domains still interact. Since the exact coordinates of the constructs are not given in the paper, the coordinates of the kinase domains in the appropriate UniProtKB entries have been used.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/08/19	2014/10/16	rogid:ngczdO33Sry0fNHG63cFjKsegn46239	rogid:Lbru/j15mbtFfQv0kZ3xFS+32Hs6239	intact-crc:C0A19F704FBDFE3B|rigid:Yq4CRwtqamJ+m9yslsP2c6nYjlw	false	sufficient binding region:392..392-463..463,1..1-134..134	sufficient binding region:1..1-193..193,451..451-528..528	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9XTG7	uniprotkb:Q2PJ68	intact:EBI-320656|uniprotkb:O77145|ensemblmetazoa:F28H6.1a.1	intact:EBI-1770776|uniprotkb:Q2PJ69|ensemblmetazoa:W10G6.2b.1	psi-mi:akt2_caeel(display_long)|uniprotkb:akt-2(gene name)|psi-mi:akt-2(display_short)|uniprotkb:Protein kinase B akt-2(gene name synonym)|uniprotkb:F28H6.1(orf name)	psi-mi:sgk1_caeel(display_long)|uniprotkb:Serum/glucocorticoid-regulated kinase 1(gene name synonym)|uniprotkb:sgk-1(gene name)|psi-mi:sgk-1(display_short)|uniprotkb:W10G6.2(orf name)|uniprotkb:Serum- and glucocorticoid-inducible kinase homolog(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Hertweck et al. (2004)	pubmed:15068796|imex:IM-20341	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2429411|imex:IM-20341-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_510357.3|wormbase:F28H6.1a|wormbase:F28H6.1b|reactome:R-CEL-392451|refseq:NP_001024612.1|ensemblmetazoa:F28H6.1a.1(transcript)|ensemblmetazoa:WBGene00000103(gene)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR039026|go:"GO:0045087"(innate immune response)|reactome:R-CEL-165158|reactome:R-CEL-1257604|reactome:R-CEL-198323|reactome:R-CEL-198693|reactome:R-CEL-199418|reactome:R-CEL-389357|reactome:R-CEL-5218920|dip:DIP-26368N|reactome:R-CEL-9634638|reactome:R-CEL-211163|reactome:R-CEL-69202|reactome:R-CEL-69656|reactome:R-CEL-8876198|reactome:R-CEL-8948751|reactome:R-CEL-9614399|reactome:R-CEL-1474151|reactome:R-CEL-165159|reactome:R-CEL-203615|reactome:R-CEL-389513|reactome:R-CEL-450385|reactome:R-CEL-450604|reactome:R-CEL-6811558|reactome:R-CEL-8849469|reactome:R-CEL-9009391|reactome:R-CEL-9604323|reactome:R-CEL-9607240	reactome:R-CEL-6804757|refseq:NP_001041298.1|refseq:NP_001041299.1|wormbase:W10G6.2a|wormbase:W10G6.2b|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|reactome:R-CEL-2672351|reactome:R-CEL-9031628|ensemblmetazoa:W10G6.2b.1(transcript)|ensemblmetazoa:WBGene00004789(gene)|go:"GO:0002119"(nematode larval development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0044255"(cellular lipid metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048382"(mesendoderm development)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903188"(positive regulation of vitellogenesis)|go:"GO:1904508"(regulation of protein localization to basolateral plasma membrane)	-	-	-	figure legend:Fig. 3C|caution:Constructs lacking kinase domains still interact. Since the exact coordinates of the constructs are not given in the paper, the coordinates of the kinase domains in the appropriate UniProtKB entries have been used.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/08/19	2014/10/16	rogid:Y8D47LHcNyTK3JpkYGj9/UCRYKs6239	rogid:ngczdO33Sry0fNHG63cFjKsegn46239	intact-crc:B48E74D1E80F83F3|rigid:2EcdN3GyNSA0x8BtqpUZihITVAo	false	sufficient binding region:438..438-515..515,1..1-180..180	sufficient binding region:392..392-463..463,1..1-134..134	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9XTG7	uniprotkb:Q17941	intact:EBI-320656|uniprotkb:O77145|ensemblmetazoa:F28H6.1a.1	intact:EBI-1770718|uniprotkb:Q17942|uniprotkb:Q8MQE0|ensemblmetazoa:C12D8.10a.1|ensemblmetazoa:C12D8.10a.2	psi-mi:akt2_caeel(display_long)|uniprotkb:akt-2(gene name)|psi-mi:akt-2(display_short)|uniprotkb:Protein kinase B akt-2(gene name synonym)|uniprotkb:F28H6.1(orf name)	psi-mi:akt1_caeel(display_long)|uniprotkb:akt-1(gene name)|psi-mi:akt-1(display_short)|uniprotkb:C12D8.10(orf name)|uniprotkb:Protein kinase B akt-1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Hertweck et al. (2004)	pubmed:15068796|imex:IM-20341	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2429426|imex:IM-20341-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_510357.3|wormbase:F28H6.1a|wormbase:F28H6.1b|reactome:R-CEL-392451|refseq:NP_001024612.1|ensemblmetazoa:F28H6.1a.1(transcript)|ensemblmetazoa:WBGene00000103(gene)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR039026|go:"GO:0045087"(innate immune response)|reactome:R-CEL-165158|reactome:R-CEL-1257604|reactome:R-CEL-198323|reactome:R-CEL-198693|reactome:R-CEL-199418|reactome:R-CEL-389357|reactome:R-CEL-5218920|dip:DIP-26368N|reactome:R-CEL-9634638|reactome:R-CEL-211163|reactome:R-CEL-69202|reactome:R-CEL-69656|reactome:R-CEL-8876198|reactome:R-CEL-8948751|reactome:R-CEL-9614399|reactome:R-CEL-1474151|reactome:R-CEL-165159|reactome:R-CEL-203615|reactome:R-CEL-389513|reactome:R-CEL-450385|reactome:R-CEL-450604|reactome:R-CEL-6811558|reactome:R-CEL-8849469|reactome:R-CEL-9009391|reactome:R-CEL-9604323|reactome:R-CEL-9607240	refseq:NP_001023645.1|refseq:NP_001023646.1|refseq:NP_001023647.1|wormbase:C12D8.10a|wormbase:C12D8.10b|wormbase:C12D8.10c|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017892|interpro:IPR001849(Pleckstrin-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR039026|mint:Q17941|ensemblmetazoa:C12D8.10a.1(transcript)|ensemblmetazoa:C12D8.10a.2(transcript)|ensemblmetazoa:WBGene00000102(gene)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0007635"(chemosensory behavior)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902074"(response to salt)|reactome:R-CEL-1257604|reactome:R-CEL-1474151|reactome:R-CEL-165158|reactome:R-CEL-165159|reactome:R-CEL-198323|reactome:R-CEL-198693|reactome:R-CEL-199418|reactome:R-CEL-203615|reactome:R-CEL-211163|reactome:R-CEL-389357|reactome:R-CEL-389513|reactome:R-CEL-392451|reactome:R-CEL-450385|reactome:R-CEL-450604|reactome:R-CEL-5218920|reactome:R-CEL-6811558|reactome:R-CEL-69202|reactome:R-CEL-69656|reactome:R-CEL-8849469|reactome:R-CEL-8876198|reactome:R-CEL-8948751|reactome:R-CEL-9009391|reactome:R-CEL-9604323|reactome:R-CEL-9607240|reactome:R-CEL-9614399|reactome:R-CEL-9634638	-	-	-	figure legend:Fig. 3C|caution:Constructs lacking kinase domains still interact. Since the exact coordinates of the constructs are not given in the paper, the coordinates of the kinase domains in the appropriate UniProtKB entries have been used.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/08/19	2014/10/16	rogid:Y8D47LHcNyTK3JpkYGj9/UCRYKs6239	rogid:Lbru/j15mbtFfQv0kZ3xFS+32Hs6239	intact-crc:9BE228FE53BF4F48|rigid:nSPysngRzlJiK67nHbpZqrIdEVQ	false	sufficient binding region:438..438-515..515,1..1-180..180	sufficient binding region:1..1-193..193,451..451-528..528	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03070	uniprotkb:P04637	intact:EBI-617698	intact:EBI-366083|uniprotkb:Q15086|uniprotkb:Q15087|uniprotkb:Q15088|uniprotkb:Q16535|uniprotkb:Q16807|uniprotkb:Q16808|uniprotkb:Q16809|uniprotkb:Q16810|uniprotkb:Q16811|uniprotkb:Q16848|uniprotkb:Q86UG1|uniprotkb:Q8J016|uniprotkb:Q99659|uniprotkb:Q9BTM4|uniprotkb:Q9HAQ8|uniprotkb:Q9NP68|uniprotkb:Q9NPJ2|uniprotkb:Q9NZD0|uniprotkb:Q9UBI2|uniprotkb:Q9UQ61|ensembl:ENSP00000269305|ensembl:ENSP00000391478|intact:EBI-28980681|uniprotkb:Q2XN98|uniprotkb:Q3LRW1|uniprotkb:Q3LRW2|uniprotkb:Q3LRW3|uniprotkb:Q3LRW4|uniprotkb:Q3LRW5	psi-mi:lt_sv40(display_long)	psi-mi:p53_human(display_long)|uniprotkb:TP53(gene name)|psi-mi:TP53(display_short)|uniprotkb:P53(gene name synonym)|uniprotkb:Tumor suppressor p53(gene name synonym)|uniprotkb:Phosphoprotein p53(gene name synonym)|uniprotkb:Antigen NY-CO-13(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Hertweck et al. (2004)	pubmed:15068796|imex:IM-20341	taxid:1891767(sv40)|taxid:1891767(sv40)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2429437|imex:IM-20341-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0016787"(hydrolase activity)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039576"(suppression by virus of host JAK-STAT cascade via inhibition of JAK1 activity)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039649"(modulation by virus of host ubiquitin-protein ligase activity)|go:"GO:0039686"(bidirectional double-stranded viral DNA replication)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR003133(T antigen, Ori-binding)|interpro:IPR010932(Large T antigen, polyomavirus,  C-terminus)|interpro:IPR016392(Large T antigen, polyomaviridae)|interpro:IPR017910|interpro:IPR027417|interpro:IPR036869|rcsb pdb:1EJL|rcsb pdb:1GH6|rcsb pdb:1N25|rcsb pdb:1Q1S|rcsb pdb:1Q1T|rcsb pdb:1SVL|rcsb pdb:1SVM|rcsb pdb:1SVO|rcsb pdb:1TBD|rcsb pdb:1Z1D|rcsb pdb:2FUF|rcsb pdb:2H1L|rcsb pdb:2IF9|rcsb pdb:2IPR|rcsb pdb:2ITJ|rcsb pdb:2ITL|rcsb pdb:2NL8|rcsb pdb:2NTC|interpro:IPR014015(Helicase, superfamily 3, DNA virus)|rcsb pdb:2TBD|rcsb pdb:3QK2|rcsb pdb:3QN2|rcsb pdb:4E2I|rcsb pdb:4FGN|rcsb pdb:4GDF|rcsb pdb:4RXH|rcsb pdb:5D9I|refseq:YP_003708382.1|mint:P03070|dip:DIP-24251N	refseq:NP_001263624.1|refseq:NP_001263625.1|ensembl:ENSG00000141510(gene)|ensembl:ENST00000269305(transcript)|ensembl:ENST00000445888(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0031497"(chromatin assembly)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035690"|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0006983"(ER overload response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007369"(gastrulation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0043621"(protein self-association)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048512"(circadian behavior)|go:"GO:0048539"(bone marrow development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062100"(positive regulation of programmed necrotic cell death)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072331"(signal transduction by p53 class mediator)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:0090399"(replicative senescence)|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097252"(oligodendrocyte apoptotic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1901525"(negative regulation of mitophagy)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902253"(regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:1905856"(negative regulation of pentose-phosphate shunt)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:1990248"(regulation of transcription from RNA polymerase II promoter in response to DNA damage)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000269"(regulation of fibroblast apoptotic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|go:"GO:0007569"(cell aging)|go:"GO:0008104"(protein localization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009299"(mRNA transcription)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009651"(response to salt stress)|go:"GO:0010165"(response to X-ray)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016032"(viral process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR036674|interpro:IPR040926|rcsb pdb:2ATA|rcsb pdb:2B3G|rcsb pdb:2BIM|rcsb pdb:2BIN|rcsb pdb:2BIO|rcsb pdb:2BIP|rcsb pdb:2AHI|rcsb pdb:2BIQ|rcsb pdb:2F1X|rcsb pdb:2FEJ|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2GS0|rcsb pdb:2H1L|rcsb pdb:2H2D|rcsb pdb:2H2F|rcsb pdb:2H4F|rcsb pdb:2H4H|rcsb pdb:2H4J|rcsb pdb:2H59|rcsb pdb:2J0Z|rcsb pdb:2J10|rcsb pdb:2J11|rcsb pdb:2J1W|rcsb pdb:2J1X|rcsb pdb:2J1Y|rcsb pdb:2J1Z|rcsb pdb:2J20|rcsb pdb:2J21|rcsb pdb:2K8F|rcsb pdb:2L14|rcsb pdb:2LY4|rcsb pdb:2MEJ|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:2MWY|rcsb pdb:2MZD|rcsb pdb:2OCJ|rcsb pdb:2PCX|rcsb pdb:1A1U|rcsb pdb:1AIE|rcsb pdb:1C26|rcsb pdb:1DT7|rcsb pdb:1GZH|rcsb pdb:1H26|rcsb pdb:1HS5|rcsb pdb:1JSP|rcsb pdb:1KZY|rcsb pdb:1MA3|rcsb pdb:1OLG|rcsb pdb:1OLH|rcsb pdb:1PES|rcsb pdb:1PET|mint:P04637|rcsb pdb:1SAE|rcsb pdb:1SAF|rcsb pdb:1SAK|rcsb pdb:1SAL|rcsb pdb:1TSR|rcsb pdb:1TUP|rcsb pdb:1UOL|rcsb pdb:1XQH|rcsb pdb:1YC5|rcsb pdb:1YCQ|rcsb pdb:1YCR|rcsb pdb:1YCS|rcsb pdb:2AC0|rcsb pdb:2ADY|refseq:NP_000537.3|refseq:NP_001119584.1|refseq:NP_001119585.1|refseq:NP_001119586.1|refseq:NP_001119587.1|refseq:NP_001119588.1|refseq:NP_001119589.1|rcsb pdb:2RUK|rcsb pdb:2VUK|rcsb pdb:3Q06|rcsb pdb:2WGX|rcsb pdb:2X0U|rcsb pdb:2X0V|rcsb pdb:2X0W|rcsb pdb:2XWR|rcsb pdb:2YBG|rcsb pdb:2YDR|rcsb pdb:2Z5S|rcsb pdb:2Z5T|rcsb pdb:3SAK|rcsb pdb:3D05|rcsb pdb:3D06|rcsb pdb:3D07|rcsb pdb:3D08|rcsb pdb:3D09|rcsb pdb:3D0A|rcsb pdb:3DAB|rcsb pdb:3DAC|rcsb pdb:3IGK|rcsb pdb:3IGL|rcsb pdb:3KMD|rcsb pdb:3TG5|rcsb pdb:3KZ8|rcsb pdb:3LW1|rcsb pdb:3OQ5|rcsb pdb:3PDH|rcsb pdb:3Q01|rcsb pdb:3Q05|rcsb pdb:3TS8|rcsb pdb:3ZME|rcsb pdb:4AGM|rcsb pdb:4AGN|rcsb pdb:4AGO|rcsb pdb:4AGP|rcsb pdb:4AGQ|rcsb pdb:4BUZ|rcsb pdb:4BV2|rcsb pdb:4HFZ|rcsb pdb:4HJE|rcsb pdb:4IBQ|rcsb pdb:4IBS|rcsb pdb:4IBT|rcsb pdb:4IBU|rcsb pdb:4IBV|rcsb pdb:4IBW|rcsb pdb:4IBY|rcsb pdb:4IBZ|rcsb pdb:4IJT|rcsb pdb:4KVP|rcsb pdb:4LO9|rcsb pdb:4LOE|rcsb pdb:4LOF|rcsb pdb:4MZI|rcsb pdb:4MZR|rcsb pdb:4QO1|rcsb pdb:4RP6|rcsb pdb:4RP7|rcsb pdb:4X34|rcsb pdb:4XR8|rcsb pdb:4ZZJ|rcsb pdb:5A7B|rcsb pdb:5AB9|rcsb pdb:5ABA|rcsb pdb:4AGL|rcsb pdb:5AOI|rcsb pdb:5AOJ|rcsb pdb:5AOK|rcsb pdb:5AOL|rcsb pdb:5AOM|rcsb pdb:6XRE|rcsb pdb:7BWN|rcsb pdb:7DHY|rcsb pdb:7DHZ|rcsb pdb:7EL4|reactome:R-HSA-111448|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-2559580|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-2559586|reactome:R-HSA-3232118|reactome:R-HSA-349425|reactome:R-HSA-390471|reactome:R-HSA-5620971|reactome:R-HSA-5628897|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5693565|reactome:R-HSA-6785807|reactome:R-HSA-6796648|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804114|reactome:R-HSA-6804115|reactome:R-HSA-6804116|reactome:R-HSA-6804754|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-6804760|reactome:R-HSA-6811555|reactome:R-HSA-69473|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69895|reactome:R-HSA-8852276|reactome:R-HSA-8853884|reactome:R-HSA-8941855|reactome:R-HSA-8943724|reactome:R-HSA-983231|rcsb pdb:5ECG|rcsb pdb:5G4M|rcsb pdb:5G4N|rcsb pdb:5BUA|rcsb pdb:5G4O|rcsb pdb:5HOU|rcsb pdb:5HP0|rcsb pdb:5HPD|rcsb pdb:5LAP|rcsb pdb:5LGY|rcsb pdb:5MCT|rcsb pdb:5MCU|rcsb pdb:5MCV|rcsb pdb:5MCW|rcsb pdb:5MF7|rcsb pdb:5MG7|rcsb pdb:5MHC|rcsb pdb:5MOC|rcsb pdb:5O1A|rcsb pdb:5O1B|rcsb pdb:5O1C|rcsb pdb:5O1D|rcsb pdb:5O1E|rcsb pdb:5O1F|rcsb pdb:5O1G|rcsb pdb:5O1H|rcsb pdb:5O1I|rcsb pdb:5OL0|rcsb pdb:5UN8|rcsb pdb:5XZC|rcsb pdb:6FF9|rcsb pdb:6FJ5|rcsb pdb:6GGA|rcsb pdb:6GGB|rcsb pdb:6GGC|rcsb pdb:6GGD|rcsb pdb:6GGE|rcsb pdb:6GGF|rcsb pdb:6LHD|rcsb pdb:6R5L|rcsb pdb:6RJZ|rcsb pdb:6RK8|rcsb pdb:6RKI|rcsb pdb:6RKK|rcsb pdb:6RKM|rcsb pdb:6RL3|rcsb pdb:6RL4|rcsb pdb:6RL6|rcsb pdb:6RM5|rcsb pdb:6RM7|rcsb pdb:6RWH|rcsb pdb:6RWI|rcsb pdb:6RWS|rcsb pdb:6RWU|rcsb pdb:6RX2|rcsb pdb:6RZ3|rcsb pdb:6S39|rcsb pdb:6S40|rcsb pdb:6S9Q|rcsb pdb:6SHZ|rcsb pdb:6SI0|rcsb pdb:6SI1|rcsb pdb:6SI2|rcsb pdb:6SI3|rcsb pdb:6SI4|rcsb pdb:6SIN|rcsb pdb:6SIO|rcsb pdb:6SIP|rcsb pdb:6SIQ|rcsb pdb:6SL6|rcsb pdb:6SLV|rcsb pdb:6T58|rcsb pdb:6V4F|rcsb pdb:6V4H|rcsb pdb:6VQO|rcsb pdb:6VR1|rcsb pdb:6VR5|rcsb pdb:6VRM|rcsb pdb:6VRN|rcsb pdb:6W51|rcsb pdb:6S3C|ensembl:ENSP00000269305|ensembl:ENST00000420246|ensembl:ENSP00000391127|ensembl:ENSP00000391478|ensembl:ENST00000455263|ensembl:ENSP00000398846|ensembl:ENST00000504290|ensembl:ENSP00000484409|ensembl:ENST00000504937|ensembl:ENSP00000481179|ensembl:ENST00000510385|ensembl:ENSP00000478499|ensembl:ENST00000610292|ensembl:ENSP00000478219|ensembl:ENST00000610538|ensembl:ENSP00000480868|ensembl:ENST00000619485|ensembl:ENSP00000482537|ensembl:ENST00000620739|ensembl:ENSP00000481638|ensembl:ENST00000622645|ensembl:ENSP00000482222|refseq:NP_001119590.1|refseq:NP_001263626.1|refseq:NP_001263627.1|refseq:NP_001263628.1|refseq:NP_001263689.1|refseq:NP_001263690.1|dip:DIP-368N	-	-	-	figure legend:Fig. 3C|comment:Positive control|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/08/19	2019/10/18	rogid:IMcAp2PRxZXkbJ1eiXhJU9rD2JM1891767	rogid:fGN3kSCGIpi/D6d/X5kaB0Xu8/k9606	intact-crc:CD1DC2E4E0A40FA3|rigid:VZOTDTO282G04bb2R4V1QRGy4IU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9XTG7	uniprotkb:Q9XTG7	intact:EBI-320656|uniprotkb:O77145|ensemblmetazoa:F28H6.1a.1	intact:EBI-320656|uniprotkb:O77145|ensemblmetazoa:F28H6.1a.1	psi-mi:akt2_caeel(display_long)|uniprotkb:akt-2(gene name)|psi-mi:akt-2(display_short)|uniprotkb:Protein kinase B akt-2(gene name synonym)|uniprotkb:F28H6.1(orf name)	psi-mi:akt2_caeel(display_long)|uniprotkb:akt-2(gene name)|psi-mi:akt-2(display_short)|uniprotkb:Protein kinase B akt-2(gene name synonym)|uniprotkb:F28H6.1(orf name)	psi-mi:"MI:0018"(two hybrid)	Hertweck et al. (2004)	pubmed:15068796|imex:IM-20341	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2435772|imex:IM-20341-18	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_510357.3|wormbase:F28H6.1a|wormbase:F28H6.1b|reactome:R-CEL-392451|refseq:NP_001024612.1|ensemblmetazoa:F28H6.1a.1(transcript)|ensemblmetazoa:WBGene00000103(gene)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR039026|go:"GO:0045087"(innate immune response)|reactome:R-CEL-165158|reactome:R-CEL-1257604|reactome:R-CEL-198323|reactome:R-CEL-198693|reactome:R-CEL-199418|reactome:R-CEL-389357|reactome:R-CEL-5218920|dip:DIP-26368N|reactome:R-CEL-9634638|reactome:R-CEL-211163|reactome:R-CEL-69202|reactome:R-CEL-69656|reactome:R-CEL-8876198|reactome:R-CEL-8948751|reactome:R-CEL-9614399|reactome:R-CEL-1474151|reactome:R-CEL-165159|reactome:R-CEL-203615|reactome:R-CEL-389513|reactome:R-CEL-450385|reactome:R-CEL-450604|reactome:R-CEL-6811558|reactome:R-CEL-8849469|reactome:R-CEL-9009391|reactome:R-CEL-9604323|reactome:R-CEL-9607240	refseq:NP_510357.3|wormbase:F28H6.1a|wormbase:F28H6.1b|reactome:R-CEL-392451|refseq:NP_001024612.1|ensemblmetazoa:F28H6.1a.1(transcript)|ensemblmetazoa:WBGene00000103(gene)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR039026|go:"GO:0045087"(innate immune response)|reactome:R-CEL-165158|reactome:R-CEL-1257604|reactome:R-CEL-198323|reactome:R-CEL-198693|reactome:R-CEL-199418|reactome:R-CEL-389357|reactome:R-CEL-5218920|dip:DIP-26368N|reactome:R-CEL-9634638|reactome:R-CEL-211163|reactome:R-CEL-69202|reactome:R-CEL-69656|reactome:R-CEL-8876198|reactome:R-CEL-8948751|reactome:R-CEL-9614399|reactome:R-CEL-1474151|reactome:R-CEL-165159|reactome:R-CEL-203615|reactome:R-CEL-389513|reactome:R-CEL-450385|reactome:R-CEL-450604|reactome:R-CEL-6811558|reactome:R-CEL-8849469|reactome:R-CEL-9009391|reactome:R-CEL-9604323|reactome:R-CEL-9607240	-	-	-	figure legend:Fig. 3C|caution:Constructs lacking kinase domains still interact. Since the exact coordinates of the constructs are not given in the paper, the coordinates of the kinase domains in the appropriate UniProtKB entries have been used.|caution:This interaction was not seen with full-length proteins and may be artefactual.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/08/19	2014/10/16	rogid:Y8D47LHcNyTK3JpkYGj9/UCRYKs6239	rogid:Y8D47LHcNyTK3JpkYGj9/UCRYKs6239	intact-crc:228729104FD50C5A|rigid:JxcimPjnoZM9yE9EeJDio5j8omg	false	sufficient binding region:438..438-515..515,1..1-180..180	sufficient binding region:438..438-515..515,1..1-180..180	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q2PJ68	uniprotkb:Q17941	intact:EBI-1770776|uniprotkb:Q2PJ69|ensemblmetazoa:W10G6.2b.1	intact:EBI-1770718|uniprotkb:Q17942|uniprotkb:Q8MQE0|ensemblmetazoa:C12D8.10a.1|ensemblmetazoa:C12D8.10a.2	psi-mi:sgk1_caeel(display_long)|uniprotkb:Serum/glucocorticoid-regulated kinase 1(gene name synonym)|uniprotkb:sgk-1(gene name)|psi-mi:sgk-1(display_short)|uniprotkb:W10G6.2(orf name)|uniprotkb:Serum- and glucocorticoid-inducible kinase homolog(gene name synonym)	psi-mi:akt1_caeel(display_long)|uniprotkb:akt-1(gene name)|psi-mi:akt-1(display_short)|uniprotkb:C12D8.10(orf name)|uniprotkb:Protein kinase B akt-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hertweck et al. (2004)	pubmed:15068796|imex:IM-20341	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2429448|imex:IM-20341-14	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-CEL-6804757|refseq:NP_001041298.1|refseq:NP_001041299.1|wormbase:W10G6.2a|wormbase:W10G6.2b|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|reactome:R-CEL-2672351|reactome:R-CEL-9031628|ensemblmetazoa:W10G6.2b.1(transcript)|ensemblmetazoa:WBGene00004789(gene)|go:"GO:0002119"(nematode larval development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0044255"(cellular lipid metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048382"(mesendoderm development)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903188"(positive regulation of vitellogenesis)|go:"GO:1904508"(regulation of protein localization to basolateral plasma membrane)	refseq:NP_001023645.1|refseq:NP_001023646.1|refseq:NP_001023647.1|wormbase:C12D8.10a|wormbase:C12D8.10b|wormbase:C12D8.10c|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017892|interpro:IPR001849(Pleckstrin-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR039026|mint:Q17941|ensemblmetazoa:C12D8.10a.1(transcript)|ensemblmetazoa:C12D8.10a.2(transcript)|ensemblmetazoa:WBGene00000102(gene)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0007635"(chemosensory behavior)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902074"(response to salt)|reactome:R-CEL-1257604|reactome:R-CEL-1474151|reactome:R-CEL-165158|reactome:R-CEL-165159|reactome:R-CEL-198323|reactome:R-CEL-198693|reactome:R-CEL-199418|reactome:R-CEL-203615|reactome:R-CEL-211163|reactome:R-CEL-389357|reactome:R-CEL-389513|reactome:R-CEL-392451|reactome:R-CEL-450385|reactome:R-CEL-450604|reactome:R-CEL-5218920|reactome:R-CEL-6811558|reactome:R-CEL-69202|reactome:R-CEL-69656|reactome:R-CEL-8849469|reactome:R-CEL-8876198|reactome:R-CEL-8948751|reactome:R-CEL-9009391|reactome:R-CEL-9604323|reactome:R-CEL-9607240|reactome:R-CEL-9614399|reactome:R-CEL-9634638	-	-	-	figure legend:Fig. 3D|comment:Increasing the concentration of akt-1 did not displace akt-2 from th complex suggesting the proteins form a trimeric complex.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/08/19	2014/10/16	rogid:ngczdO33Sry0fNHG63cFjKsegn46239	rogid:Lbru/j15mbtFfQv0kZ3xFS+32Hs6239	intact-crc:950ED0CB67030831|rigid:3F/dZtExjwBFjM3A0v8ntdFFaFQ	false	glutathione s tranferase tag:?-?	vsv tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q2PJ68	uniprotkb:Q9XTG7	intact:EBI-1770776|uniprotkb:Q2PJ69|ensemblmetazoa:W10G6.2b.1	intact:EBI-320656|uniprotkb:O77145|ensemblmetazoa:F28H6.1a.1	psi-mi:sgk1_caeel(display_long)|uniprotkb:Serum/glucocorticoid-regulated kinase 1(gene name synonym)|uniprotkb:sgk-1(gene name)|psi-mi:sgk-1(display_short)|uniprotkb:W10G6.2(orf name)|uniprotkb:Serum- and glucocorticoid-inducible kinase homolog(gene name synonym)	psi-mi:akt2_caeel(display_long)|uniprotkb:akt-2(gene name)|psi-mi:akt-2(display_short)|uniprotkb:Protein kinase B akt-2(gene name synonym)|uniprotkb:F28H6.1(orf name)	psi-mi:"MI:0096"(pull down)	Hertweck et al. (2004)	pubmed:15068796|imex:IM-20341	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2429448|imex:IM-20341-14	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-CEL-6804757|refseq:NP_001041298.1|refseq:NP_001041299.1|wormbase:W10G6.2a|wormbase:W10G6.2b|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|reactome:R-CEL-2672351|reactome:R-CEL-9031628|ensemblmetazoa:W10G6.2b.1(transcript)|ensemblmetazoa:WBGene00004789(gene)|go:"GO:0002119"(nematode larval development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0044255"(cellular lipid metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048382"(mesendoderm development)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903188"(positive regulation of vitellogenesis)|go:"GO:1904508"(regulation of protein localization to basolateral plasma membrane)	refseq:NP_510357.3|wormbase:F28H6.1a|wormbase:F28H6.1b|reactome:R-CEL-392451|refseq:NP_001024612.1|ensemblmetazoa:F28H6.1a.1(transcript)|ensemblmetazoa:WBGene00000103(gene)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR039026|go:"GO:0045087"(innate immune response)|reactome:R-CEL-165158|reactome:R-CEL-1257604|reactome:R-CEL-198323|reactome:R-CEL-198693|reactome:R-CEL-199418|reactome:R-CEL-389357|reactome:R-CEL-5218920|dip:DIP-26368N|reactome:R-CEL-9634638|reactome:R-CEL-211163|reactome:R-CEL-69202|reactome:R-CEL-69656|reactome:R-CEL-8876198|reactome:R-CEL-8948751|reactome:R-CEL-9614399|reactome:R-CEL-1474151|reactome:R-CEL-165159|reactome:R-CEL-203615|reactome:R-CEL-389513|reactome:R-CEL-450385|reactome:R-CEL-450604|reactome:R-CEL-6811558|reactome:R-CEL-8849469|reactome:R-CEL-9009391|reactome:R-CEL-9604323|reactome:R-CEL-9607240	-	-	-	figure legend:Fig. 3D|comment:Increasing the concentration of akt-1 did not displace akt-2 from th complex suggesting the proteins form a trimeric complex.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/08/19	2014/10/16	rogid:ngczdO33Sry0fNHG63cFjKsegn46239	rogid:Y8D47LHcNyTK3JpkYGj9/UCRYKs6239	intact-crc:950ED0CB67030831|rigid:3F/dZtExjwBFjM3A0v8ntdFFaFQ	false	glutathione s tranferase tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q2PJ68	uniprotkb:O16850	intact:EBI-1770776|uniprotkb:Q2PJ69|ensemblmetazoa:W10G6.2b.1	intact:EBI-324028|uniprotkb:O16849|uniprotkb:O18676|uniprotkb:Q86S42|intact:EBI-1770827|uniprotkb:F3NWW7|uniprotkb:F3NWX0|uniprotkb:G4RQR7|uniprotkb:G4S686|uniprotkb:G4SKG3|uniprotkb:G4SKH0|ensemblmetazoa:R13H8.1h.1	psi-mi:sgk1_caeel(display_long)|uniprotkb:Serum/glucocorticoid-regulated kinase 1(gene name synonym)|uniprotkb:sgk-1(gene name)|psi-mi:sgk-1(display_short)|uniprotkb:W10G6.2(orf name)|uniprotkb:Serum- and glucocorticoid-inducible kinase homolog(gene name synonym)	psi-mi:foxo_caeel(display_long)|uniprotkb:Abnormal dauer formation protein 16(gene name synonym)|uniprotkb:daf-16(gene name)|psi-mi:daf-16(display_short)|uniprotkb:R13H8.1(orf name)	psi-mi:"MI:0424"(protein kinase assay)	Hertweck et al. (2004)	pubmed:15068796|imex:IM-20341	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2429467|imex:IM-20341-15	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-CEL-6804757|refseq:NP_001041298.1|refseq:NP_001041299.1|wormbase:W10G6.2a|wormbase:W10G6.2b|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|reactome:R-CEL-2672351|reactome:R-CEL-9031628|ensemblmetazoa:W10G6.2b.1(transcript)|ensemblmetazoa:WBGene00004789(gene)|go:"GO:0002119"(nematode larval development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0044255"(cellular lipid metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048382"(mesendoderm development)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903188"(positive regulation of vitellogenesis)|go:"GO:1904508"(regulation of protein localization to basolateral plasma membrane)	refseq:NP_001021593.1|refseq:NP_001021594.1|refseq:NP_001021595.1|refseq:NP_001021597.1|wormbase:R13H8.1a|wormbase:R13H8.1b|wormbase:R13H8.1c|wormbase:R13H8.1e|refseq:NP_001021596.1|reactome:R-CEL-9607240|refseq:NP_001021598.2|refseq:NP_001251490.1|refseq:NP_001251492.1|reactome:R-CEL-9614399|reactome:R-CEL-9615017|reactome:R-CEL-9617629|wormbase:R13H8.1d|wormbase:R13H8.1f|wormbase:R13H8.1g|wormbase:R13H8.1h|ensemblmetazoa:R13H8.1h.1(transcript)|ensemblmetazoa:WBGene00000912(gene)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0002119"(nematode larval development)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0007614"(short-term memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0009411"(response to UV)|go:"GO:0010286"(heat acclimation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010564"(regulation of cell cycle process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0040024"(dauer larval development)|go:"GO:0042594"(response to starvation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043620"(regulation of DNA-templated transcription in response to stress)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046890"(regulation of lipid biosynthetic process)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060537"(muscle tissue development)|go:"GO:0061065"(regulation of dauer larval development)|go:"GO:0061066"(positive regulation of dauer larval development)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900075"(positive regulation of neuromuscular synaptic transmission)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1905909"(regulation of dauer entry)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|go:"GO:0045087"(innate immune response)|reactome:R-CEL-198693|reactome:R-CEL-211163|reactome:R-CEL-5687128|dip:DIP-25581N|reactome:R-CEL-5689880|reactome:R-CEL-1181150|reactome:R-CEL-9617828|reactome:R-CEL-9634638	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:Fig. 4A|comment:sgk-1 purified from worms lacking active pdk-1 was not able to phsophorylate daf-16.|resulting-ptm:"Phosphorylation of daf-16 (O16849)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/08/19	2014/10/16	rogid:ngczdO33Sry0fNHG63cFjKsegn46239	rogid:UfAMA8NPgcJv93n6XAjW5mLboZQ6239	intact-crc:5E397AC98B350BB2|rigid:21e4TpoNrajtb1ZnWT35+afA0yU	false	glutathione s tranferase tag:?-?	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q17941	uniprotkb:O16850	intact:EBI-1770718|uniprotkb:Q17942|uniprotkb:Q8MQE0|ensemblmetazoa:C12D8.10a.1|ensemblmetazoa:C12D8.10a.2	intact:EBI-324028|uniprotkb:O16849|uniprotkb:O18676|uniprotkb:Q86S42|intact:EBI-1770827|uniprotkb:F3NWW7|uniprotkb:F3NWX0|uniprotkb:G4RQR7|uniprotkb:G4S686|uniprotkb:G4SKG3|uniprotkb:G4SKH0|ensemblmetazoa:R13H8.1h.1	psi-mi:akt1_caeel(display_long)|uniprotkb:akt-1(gene name)|psi-mi:akt-1(display_short)|uniprotkb:C12D8.10(orf name)|uniprotkb:Protein kinase B akt-1(gene name synonym)	psi-mi:foxo_caeel(display_long)|uniprotkb:Abnormal dauer formation protein 16(gene name synonym)|uniprotkb:daf-16(gene name)|psi-mi:daf-16(display_short)|uniprotkb:R13H8.1(orf name)	psi-mi:"MI:0424"(protein kinase assay)	Hertweck et al. (2004)	pubmed:15068796|imex:IM-20341	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2429479|imex:IM-20341-16	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001023645.1|refseq:NP_001023646.1|refseq:NP_001023647.1|wormbase:C12D8.10a|wormbase:C12D8.10b|wormbase:C12D8.10c|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017892|interpro:IPR001849(Pleckstrin-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR039026|mint:Q17941|ensemblmetazoa:C12D8.10a.1(transcript)|ensemblmetazoa:C12D8.10a.2(transcript)|ensemblmetazoa:WBGene00000102(gene)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0007635"(chemosensory behavior)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902074"(response to salt)|reactome:R-CEL-1257604|reactome:R-CEL-1474151|reactome:R-CEL-165158|reactome:R-CEL-165159|reactome:R-CEL-198323|reactome:R-CEL-198693|reactome:R-CEL-199418|reactome:R-CEL-203615|reactome:R-CEL-211163|reactome:R-CEL-389357|reactome:R-CEL-389513|reactome:R-CEL-392451|reactome:R-CEL-450385|reactome:R-CEL-450604|reactome:R-CEL-5218920|reactome:R-CEL-6811558|reactome:R-CEL-69202|reactome:R-CEL-69656|reactome:R-CEL-8849469|reactome:R-CEL-8876198|reactome:R-CEL-8948751|reactome:R-CEL-9009391|reactome:R-CEL-9604323|reactome:R-CEL-9607240|reactome:R-CEL-9614399|reactome:R-CEL-9634638	refseq:NP_001021593.1|refseq:NP_001021594.1|refseq:NP_001021595.1|refseq:NP_001021597.1|wormbase:R13H8.1a|wormbase:R13H8.1b|wormbase:R13H8.1c|wormbase:R13H8.1e|refseq:NP_001021596.1|reactome:R-CEL-9607240|refseq:NP_001021598.2|refseq:NP_001251490.1|refseq:NP_001251492.1|reactome:R-CEL-9614399|reactome:R-CEL-9615017|reactome:R-CEL-9617629|wormbase:R13H8.1d|wormbase:R13H8.1f|wormbase:R13H8.1g|wormbase:R13H8.1h|ensemblmetazoa:R13H8.1h.1(transcript)|ensemblmetazoa:WBGene00000912(gene)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0002119"(nematode larval development)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0007614"(short-term memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0009411"(response to UV)|go:"GO:0010286"(heat acclimation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010564"(regulation of cell cycle process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0040024"(dauer larval development)|go:"GO:0042594"(response to starvation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043620"(regulation of DNA-templated transcription in response to stress)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046890"(regulation of lipid biosynthetic process)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060537"(muscle tissue development)|go:"GO:0061065"(regulation of dauer larval development)|go:"GO:0061066"(positive regulation of dauer larval development)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900075"(positive regulation of neuromuscular synaptic transmission)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1905909"(regulation of dauer entry)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|go:"GO:0045087"(innate immune response)|reactome:R-CEL-198693|reactome:R-CEL-211163|reactome:R-CEL-5687128|dip:DIP-25581N|reactome:R-CEL-5689880|reactome:R-CEL-1181150|reactome:R-CEL-9617828|reactome:R-CEL-9634638	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	figure legend:Fig. 4A|comment:akt-1 purified from worms lacking active pdk-1 was not able to phsophorylate daf-16.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/08/19	2014/10/16	rogid:Lbru/j15mbtFfQv0kZ3xFS+32Hs6239	rogid:UfAMA8NPgcJv93n6XAjW5mLboZQ6239	intact-crc:523AA167C7B4FE0A|rigid:i9XRxd1yDYpUfFzltbHwudiZ2uo	false	green fluorescent protein tag:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:O16850	uniprotkb:Q9XTG7	intact:EBI-324028|uniprotkb:O16849|uniprotkb:O18676|uniprotkb:Q86S42|intact:EBI-1770827|uniprotkb:F3NWW7|uniprotkb:F3NWX0|uniprotkb:G4RQR7|uniprotkb:G4S686|uniprotkb:G4SKG3|uniprotkb:G4SKH0|ensemblmetazoa:R13H8.1h.1	intact:EBI-320656|uniprotkb:O77145|ensemblmetazoa:F28H6.1a.1	psi-mi:foxo_caeel(display_long)|uniprotkb:Abnormal dauer formation protein 16(gene name synonym)|uniprotkb:daf-16(gene name)|psi-mi:daf-16(display_short)|uniprotkb:R13H8.1(orf name)	psi-mi:akt2_caeel(display_long)|uniprotkb:akt-2(gene name)|psi-mi:akt-2(display_short)|uniprotkb:Protein kinase B akt-2(gene name synonym)|uniprotkb:F28H6.1(orf name)	psi-mi:"MI:0424"(protein kinase assay)	Hertweck et al. (2004)	pubmed:15068796|imex:IM-20341	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2429490|imex:IM-20341-17	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001021593.1|refseq:NP_001021594.1|refseq:NP_001021595.1|refseq:NP_001021597.1|wormbase:R13H8.1a|wormbase:R13H8.1b|wormbase:R13H8.1c|wormbase:R13H8.1e|refseq:NP_001021596.1|reactome:R-CEL-9607240|refseq:NP_001021598.2|refseq:NP_001251490.1|refseq:NP_001251492.1|reactome:R-CEL-9614399|reactome:R-CEL-9615017|reactome:R-CEL-9617629|wormbase:R13H8.1d|wormbase:R13H8.1f|wormbase:R13H8.1g|wormbase:R13H8.1h|ensemblmetazoa:R13H8.1h.1(transcript)|ensemblmetazoa:WBGene00000912(gene)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0002119"(nematode larval development)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0007614"(short-term memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0009411"(response to UV)|go:"GO:0010286"(heat acclimation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010564"(regulation of cell cycle process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0040024"(dauer larval development)|go:"GO:0042594"(response to starvation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043620"(regulation of DNA-templated transcription in response to stress)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046890"(regulation of lipid biosynthetic process)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060537"(muscle tissue development)|go:"GO:0061065"(regulation of dauer larval development)|go:"GO:0061066"(positive regulation of dauer larval development)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900075"(positive regulation of neuromuscular synaptic transmission)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1905909"(regulation of dauer entry)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|go:"GO:0045087"(innate immune response)|reactome:R-CEL-198693|reactome:R-CEL-211163|reactome:R-CEL-5687128|dip:DIP-25581N|reactome:R-CEL-5689880|reactome:R-CEL-1181150|reactome:R-CEL-9617828|reactome:R-CEL-9634638	refseq:NP_510357.3|wormbase:F28H6.1a|wormbase:F28H6.1b|reactome:R-CEL-392451|refseq:NP_001024612.1|ensemblmetazoa:F28H6.1a.1(transcript)|ensemblmetazoa:WBGene00000103(gene)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR039026|go:"GO:0045087"(innate immune response)|reactome:R-CEL-165158|reactome:R-CEL-1257604|reactome:R-CEL-198323|reactome:R-CEL-198693|reactome:R-CEL-199418|reactome:R-CEL-389357|reactome:R-CEL-5218920|dip:DIP-26368N|reactome:R-CEL-9634638|reactome:R-CEL-211163|reactome:R-CEL-69202|reactome:R-CEL-69656|reactome:R-CEL-8876198|reactome:R-CEL-8948751|reactome:R-CEL-9614399|reactome:R-CEL-1474151|reactome:R-CEL-165159|reactome:R-CEL-203615|reactome:R-CEL-389513|reactome:R-CEL-450385|reactome:R-CEL-450604|reactome:R-CEL-6811558|reactome:R-CEL-8849469|reactome:R-CEL-9009391|reactome:R-CEL-9604323|reactome:R-CEL-9607240	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	figure legend:Fig. 4A|comment:akt-2 purified from worms lacking active pdk-1 was not able to phsophorylate daf-16.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/08/19	2014/10/16	rogid:UfAMA8NPgcJv93n6XAjW5mLboZQ6239	rogid:Y8D47LHcNyTK3JpkYGj9/UCRYKs6239	intact-crc:424AB38668A74921|rigid:6Gay1LRzU1w7M7nm4AvpTN8r9+s	false	glutathione s tranferase tag:?-?	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)