#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9HCB6	uniprotkb:P05067-4	intact:EBI-2431846|uniprotkb:O94862|uniprotkb:Q8NCD7|uniprotkb:Q8WUR5|uniprotkb:A8K6W5|ensembl:ENSP00000460236	intact:EBI-302641|ensembl:ENSP00000345463|intact:EBI-8513344|intact:MINT-150885|intact:EBI-8513450|intact:EBI-8513789|intact:EBI-7458081|intact:EBI-7458225|intact:EBI-8513738|intact:EBI-8513677|intact:EBI-8513407|intact:EBI-7457926	psi-mi:spon1_human(display_long)|uniprotkb:VSGP(gene name synonym)|uniprotkb:SPON1(gene name)|psi-mi:SPON1(display_short)|uniprotkb:KIAA0762(gene name synonym)|uniprotkb:F-spondin(gene name synonym)|uniprotkb:Vascular smooth muscle cell growth-promoting factor(gene name synonym)	psi-mi:p05067-4(display_long)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:PreA4 695(isoform synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0096"(pull down)	Ho et al. (2004)	pubmed:14983046|imex:IM-19303	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2431840|imex:IM-19303-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006099.2|ensembl:ENSG00000262655(gene)|ensembl:ENST00000576479(transcript)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0007155"(cell adhesion)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050693"(LBD domain binding)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902993"(positive regulation of amyloid precursor protein catabolic process)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR002861(Reeler region)|interpro:IPR009465(Spondin, N-terminal)|interpro:IPR036383|interpro:IPR038678|interpro:IPR042307|interpro:IPR044004|rcsb pdb:2ZOT|rcsb pdb:2ZOU|rcsb pdb:3COO|rcsb pdb:3Q13|reactome:R-HSA-5083635|reactome:R-HSA-5173214	intact:EBI-77613(a4_human)|ensembl:ENSG00000142192(gene)|ensembl:ENST00000348990(transcript)	-	-	isoform-comment:A major isoform.	figure legend:Fig 1B|comment:Ig-fusion protein with only N-term domains fo APP does not interact with SPON1.|comment:Ca2+ required for binding interaction.|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/09/01	2014/10/16	rogid:JcGJxTWGd1uiIpYe8ZiPQ24jgUY9606	rogid:g3lIuSzu8RGEONgITBEVFyMpfqk9606	intact-crc:5EF654183DF6D5AB|rigid:8mW+uRAQAhi6Cd5mdECBJtGYFMQ	false	-	tag:c-c|sufficient binding region:286-557	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P05067-4	uniprotkb:Q9HCB6	intact:EBI-302641|ensembl:ENSP00000345463|intact:EBI-8513344|intact:MINT-150885|intact:EBI-8513450|intact:EBI-8513789|intact:EBI-7458081|intact:EBI-7458225|intact:EBI-8513738|intact:EBI-8513677|intact:EBI-8513407|intact:EBI-7457926	intact:EBI-2431846|uniprotkb:O94862|uniprotkb:Q8NCD7|uniprotkb:Q8WUR5|uniprotkb:A8K6W5|ensembl:ENSP00000460236	psi-mi:p05067-4(display_long)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:PreA4 695(isoform synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:spon1_human(display_long)|uniprotkb:VSGP(gene name synonym)|uniprotkb:SPON1(gene name)|psi-mi:SPON1(display_short)|uniprotkb:KIAA0762(gene name synonym)|uniprotkb:F-spondin(gene name synonym)|uniprotkb:Vascular smooth muscle cell growth-promoting factor(gene name synonym)	psi-mi:"MI:0096"(pull down)	Ho et al. (2004)	pubmed:14983046|imex:IM-19303	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2431869|imex:IM-19303-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-77613(a4_human)|ensembl:ENSG00000142192(gene)|ensembl:ENST00000348990(transcript)	refseq:NP_006099.2|ensembl:ENSG00000262655(gene)|ensembl:ENST00000576479(transcript)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0007155"(cell adhesion)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050693"(LBD domain binding)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902993"(positive regulation of amyloid precursor protein catabolic process)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR002861(Reeler region)|interpro:IPR009465(Spondin, N-terminal)|interpro:IPR036383|interpro:IPR038678|interpro:IPR042307|interpro:IPR044004|rcsb pdb:2ZOT|rcsb pdb:2ZOU|rcsb pdb:3COO|rcsb pdb:3Q13|reactome:R-HSA-5083635|reactome:R-HSA-5173214	-	isoform-comment:A major isoform.	-	figure legend:Fig2b|comment:6 deletion constructs of SPON1 Ig-fusion protein used to determine essential binding region with APP.|comment:Authors state that native brain APP also specifically retained by SPON1 but do not present any data.|data-processing:Authors do not specify how recombinant Ig-SPON1 construct is expressed, however Ig-APP recombinant proteins were expressed in COS cells.|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/09/01	2014/10/16	rogid:g3lIuSzu8RGEONgITBEVFyMpfqk9606	rogid:JcGJxTWGd1uiIpYe8ZiPQ24jgUY9606	intact-crc:2101C2C0FA50F531|rigid:8mW+uRAQAhi6Cd5mdECBJtGYFMQ	false	-	tag:c-c|necessary binding region:1-501	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P51693	uniprotkb:Q9HCB6	intact:EBI-74648|uniprotkb:O00113|uniprotkb:Q96A92|ensembl:ENSP00000498366	intact:EBI-2431846|uniprotkb:O94862|uniprotkb:Q8NCD7|uniprotkb:Q8WUR5|uniprotkb:A8K6W5|ensembl:ENSP00000460236	psi-mi:aplp1_human(display_long)|uniprotkb:APLP1(gene name)|psi-mi:APLP1(display_short)|uniprotkb:"Amyloid beta (A4) precursor-like protein 1"(gene name synonym)|uniprotkb:Amyloid-like protein 1(gene name synonym)	psi-mi:spon1_human(display_long)|uniprotkb:VSGP(gene name synonym)|uniprotkb:SPON1(gene name)|psi-mi:SPON1(display_short)|uniprotkb:KIAA0762(gene name synonym)|uniprotkb:F-spondin(gene name synonym)|uniprotkb:Vascular smooth muscle cell growth-promoting factor(gene name synonym)	psi-mi:"MI:0096"(pull down)	Ho et al. (2004)	pubmed:14983046|imex:IM-19303	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2431882|imex:IM-19303-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001019978.1|refseq:NP_005157.1|dip:DIP-30846N|ensembl:ENSG00000105290(gene)|ensembl:ENST00000652533(transcript)|go:"GO:0005604"(basement membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008201"(heparin binding)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030900"(forebrain development)|go:"GO:0031694"(alpha-2A adrenergic receptor binding)|go:"GO:0031695"(alpha-2B adrenergic receptor binding)|go:"GO:0031696"(alpha-2C adrenergic receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0046914"(transition metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071874"(cellular response to norepinephrine stimulus)|go:"GO:0106072"(negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|interpro:IPR008154(Amyloidogenic glycoprotein, extracellular)|interpro:IPR008155(Amyloidogenic glycoprotein, core)|interpro:IPR011178(Amyloidogenic glycoprotein, copper-binding)|interpro:IPR015849(Amyloidogenic glycoprotein, heparin-binding)|interpro:IPR019543|interpro:IPR019744|interpro:IPR019745|interpro:IPR024329|interpro:IPR036176|interpro:IPR036669|rcsb pdb:3PMR|rcsb pdb:3Q7G|rcsb pdb:3Q7L|rcsb pdb:3QMK|rcsb pdb:4RD9|rcsb pdb:4RDA|interpro:IPR036454	refseq:NP_006099.2|ensembl:ENSG00000262655(gene)|ensembl:ENST00000576479(transcript)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0007155"(cell adhesion)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050693"(LBD domain binding)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902993"(positive regulation of amyloid precursor protein catabolic process)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR002861(Reeler region)|interpro:IPR009465(Spondin, N-terminal)|interpro:IPR036383|interpro:IPR038678|interpro:IPR042307|interpro:IPR044004|rcsb pdb:2ZOT|rcsb pdb:2ZOU|rcsb pdb:3COO|rcsb pdb:3Q13|reactome:R-HSA-5083635|reactome:R-HSA-5173214	-	-	-	figure legend:Fig2|comment:Authors do not specify how recombinant Ig-SPON1 construct is expressed, however Ig-APP recombinant proteins were expressed in COS cells.|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/09/01	2014/10/16	rogid:6PKn8miZNOLOS3c4MjZFchs1yaQ9606	rogid:JcGJxTWGd1uiIpYe8ZiPQ24jgUY9606	intact-crc:E79AD34B7B4492E0|rigid:1SD0CIRV0GoHegZ43j1PWoTkFQg	false	-	necessary binding region:1-501|tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q06481	uniprotkb:Q9HCB6	intact:EBI-79306|uniprotkb:Q13861|uniprotkb:Q14594|uniprotkb:Q14662|uniprotkb:Q71U10|uniprotkb:Q7M4L3|uniprotkb:Q9BT36|ensembl:ENSP00000263574|ensembl:ENSP00000497691|uniprotkb:B3KXX9|uniprotkb:H7BXI4	intact:EBI-2431846|uniprotkb:O94862|uniprotkb:Q8NCD7|uniprotkb:Q8WUR5|uniprotkb:A8K6W5|ensembl:ENSP00000460236	psi-mi:aplp2_human(display_long)|uniprotkb:APPH(gene name synonym)|uniprotkb:APPL2(gene name synonym)|uniprotkb:APLP2(gene name)|psi-mi:APLP2(display_short)|uniprotkb:Amyloid protein homolog(gene name synonym)|uniprotkb:CDEI box-binding protein(gene name synonym)|uniprotkb:"Amyloid beta (A4) precursor-like protein 2"(gene name synonym)|uniprotkb:Amyloid-like protein 2(gene name synonym)|uniprotkb:Sperm membrane protein YWK-II(gene name synonym)	psi-mi:spon1_human(display_long)|uniprotkb:VSGP(gene name synonym)|uniprotkb:SPON1(gene name)|psi-mi:SPON1(display_short)|uniprotkb:KIAA0762(gene name synonym)|uniprotkb:F-spondin(gene name synonym)|uniprotkb:Vascular smooth muscle cell growth-promoting factor(gene name synonym)	psi-mi:"MI:0096"(pull down)	Ho et al. (2004)	pubmed:14983046|imex:IM-19303	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2431892|imex:IM-19303-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001135748.1|refseq:NP_001135749.1|refseq:NP_001135750.1|refseq:NP_001633.1|ensembl:ENSG00000084234(gene)|ensembl:ENST00000263574(transcript)|ensembl:ENST00000650012(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046914"(transition metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002223(Proteinase inhibitor I2, Kunitz metazoa)|interpro:IPR008154(Amyloidogenic glycoprotein, extracellular)|interpro:IPR008155(Amyloidogenic glycoprotein, core)|interpro:IPR011178(Amyloidogenic glycoprotein, copper-binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015849(Amyloidogenic glycoprotein, heparin-binding)|interpro:IPR019543|interpro:IPR019744|interpro:IPR019745|interpro:IPR020901|interpro:IPR024329|interpro:IPR036176|interpro:IPR036454|interpro:IPR036669|interpro:IPR036880|mint:Q06481|rcsb pdb:5JBT|rcsb pdb:5TPT|reactome:R-HSA-114608|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_001230228.1|dip:DIP-31047N	refseq:NP_006099.2|ensembl:ENSG00000262655(gene)|ensembl:ENST00000576479(transcript)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0007155"(cell adhesion)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050693"(LBD domain binding)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902993"(positive regulation of amyloid precursor protein catabolic process)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR002861(Reeler region)|interpro:IPR009465(Spondin, N-terminal)|interpro:IPR036383|interpro:IPR038678|interpro:IPR042307|interpro:IPR044004|rcsb pdb:2ZOT|rcsb pdb:2ZOU|rcsb pdb:3COO|rcsb pdb:3Q13|reactome:R-HSA-5083635|reactome:R-HSA-5173214	-	-	-	figure legend:Fig2d|comment:Authors do not specify how recombinant Ig-SPON1 construct is expressed, however Ig-APP recombinant proteins were expressed in COS cells.|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/09/01	2014/10/16	rogid:WBmrQxD6+MjRPRNHt63XDIs9++o9606	rogid:JcGJxTWGd1uiIpYe8ZiPQ24jgUY9606	intact-crc:300C1FB627F80482|rigid:GrXqr0eKiYmFE33v1y0pgYrVFcI	false	-	necessary binding region:1-501|tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P05067-4	uniprotkb:Q9HCB6	intact:EBI-302641|ensembl:ENSP00000345463|intact:EBI-8513344|intact:MINT-150885|intact:EBI-8513450|intact:EBI-8513789|intact:EBI-7458081|intact:EBI-7458225|intact:EBI-8513738|intact:EBI-8513677|intact:EBI-8513407|intact:EBI-7457926	intact:EBI-2431846|uniprotkb:O94862|uniprotkb:Q8NCD7|uniprotkb:Q8WUR5|uniprotkb:A8K6W5|ensembl:ENSP00000460236	psi-mi:p05067-4(display_long)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:PreA4 695(isoform synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:spon1_human(display_long)|uniprotkb:VSGP(gene name synonym)|uniprotkb:SPON1(gene name)|psi-mi:SPON1(display_short)|uniprotkb:KIAA0762(gene name synonym)|uniprotkb:F-spondin(gene name synonym)|uniprotkb:Vascular smooth muscle cell growth-promoting factor(gene name synonym)	psi-mi:"MI:0096"(pull down)	Ho et al. (2004)	pubmed:14983046|imex:IM-19303	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2431902|imex:IM-19303-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-77613(a4_human)|ensembl:ENSG00000142192(gene)|ensembl:ENST00000348990(transcript)	refseq:NP_006099.2|ensembl:ENSG00000262655(gene)|ensembl:ENST00000576479(transcript)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0007155"(cell adhesion)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050693"(LBD domain binding)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902993"(positive regulation of amyloid precursor protein catabolic process)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR002861(Reeler region)|interpro:IPR009465(Spondin, N-terminal)|interpro:IPR036383|interpro:IPR038678|interpro:IPR042307|interpro:IPR044004|rcsb pdb:2ZOT|rcsb pdb:2ZOU|rcsb pdb:3COO|rcsb pdb:3Q13|reactome:R-HSA-5083635|reactome:R-HSA-5173214	-	isoform-comment:A major isoform.	-	figure legend:Fig2c|data-processing:Authors do not specify how recombinant Ig-SPON1 construct is expressed, however Ig-APP recombinant proteins were expressed in COS cells.|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/09/01	2014/10/16	rogid:g3lIuSzu8RGEONgITBEVFyMpfqk9606	rogid:JcGJxTWGd1uiIpYe8ZiPQ24jgUY9606	intact-crc:99FEEF16E4AF66F6|rigid:8mW+uRAQAhi6Cd5mdECBJtGYFMQ	false	necessary binding region:365-568	tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35446	uniprotkb:P05067-4	intact:EBI-2432084	intact:EBI-302641|ensembl:ENSP00000345463|intact:EBI-8513344|intact:MINT-150885|intact:EBI-8513450|intact:EBI-8513789|intact:EBI-7458081|intact:EBI-7458225|intact:EBI-8513738|intact:EBI-8513677|intact:EBI-8513407|intact:EBI-7457926	psi-mi:spon1_rat(display_long)|uniprotkb:Spon1(gene name)|psi-mi:Spon1(display_short)|uniprotkb:Sponf(gene name synonym)|uniprotkb:F-spondin(gene name synonym)	psi-mi:p05067-4(display_long)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:PreA4 695(isoform synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0096"(pull down)	Ho et al. (2004)	pubmed:14983046|imex:IM-19303	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2432080|imex:IM-19303-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR038678|rgd:619918|refseq:NP_742064.1|interpro:IPR002861(Reeler region)|interpro:IPR009465(Spondin, N-terminal)|interpro:IPR000884(Thrombospondin, type I)|rcsb pdb:1SZL|rcsb pdb:1VEX|interpro:IPR042307|interpro:IPR036383|reactome:R-RNO-5173214|interpro:IPR044004|go:"GO:0005576"(extracellular region)|go:"GO:0007155"(cell adhesion)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050693"(LBD domain binding)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902993"(positive regulation of amyloid precursor protein catabolic process)	intact:EBI-77613(a4_human)|ensembl:ENSG00000142192(gene)|ensembl:ENST00000348990(transcript)	-	-	isoform-comment:A major isoform.	figure legend:Fig1|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/09/01	2014/10/16	rogid:t+aPf/D9/JOZ6KUYOLd1KuCVKcg10116	rogid:g3lIuSzu8RGEONgITBEVFyMpfqk9606	intact-crc:4111DFD4A163600E|rigid:ccg43SgN0Qs0e5jlN3JI04lcdus	false	-	glutathione s tranferase tag:n-n|sufficient binding region:286-557	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)