#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P14003	uniprotkb:Q9V8P9	intact:EBI-123011|intact:EBI-1639662|uniprotkb:A4V1N7|uniprotkb:Q95NH3|uniprotkb:Q95NU9|uniprotkb:Q9VSN8|ensemblmetazoa:FBpp0076296|ensemblmetazoa:FBpp0099504	intact:EBI-147805|ensemblmetazoa:FBpp0085754|ensemblmetazoa:FBpp0304302	psi-mi:hair_drome(display_long)|uniprotkb:CG6494(orf name)|uniprotkb:h(gene name)|psi-mi:h(display_short)	psi-mi:toprs_drome(display_long)|uniprotkb:Topors(gene name)|psi-mi:Topors(display_short)|uniprotkb:dTopors(gene name synonym)|uniprotkb:SUMO1-protein E3 ligase Topors(gene name synonym)|uniprotkb:Topoisomerase I-binding RING finger protein(gene name synonym)|uniprotkb:Topoisomerase I-binding arginine/serine-rich protein(gene name synonym)|uniprotkb:CG15104(orf name)|uniprotkb:RING-type E3 ubiquitin transferase Topors(gene name synonym)	psi-mi:"MI:0096"(pull down)	Secombe et al. (2004)	pubmed:14871887|imex:IM-19298	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2295654|imex:IM-19298-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001014577.1|refseq:NP_523977.2|flybase:FBgn0001168|ensemblmetazoa:FBgn0001168(gene)|ensemblmetazoa:FBtr0076569(transcript)|ensemblmetazoa:FBtr0100153(transcript)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0035290"(trunk segmentation)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0061024"(membrane organization)|go:"GO:0070888"(E-box binding)|interpro:IPR003650(Orange)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|mint:P14003|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007366"(periodic partitioning by pair rule gene)|go:"GO:0007399"(nervous system development)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0031323"(regulation of cellular metabolic process)|go:"GO:0035239"(tube morphogenesis)|go:"GO:0035289"(posterior head segmentation)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|dip:DIP-637N	flybase:FBgn0267351|refseq:NP_611388.1|refseq:NP_001261083.1|ensemblmetazoa:FBgn0267351(gene)|ensemblmetazoa:FBtr0086570(transcript)|ensemblmetazoa:FBtr0331977(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005700"(polytene chromosome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0006325"(chromatin organization)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006997"(nucleus organization)|go:"GO:0007060"(male meiosis chromosome segregation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0016558"(protein import into peroxisome matrix)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0051299"(centrosome separation)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0071763"(nuclear membrane organization)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957	-	-	-	figure legend:1A, 3A, 3B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/03/25	2014/10/16	rogid:bO023bTsk72HhqvmgSjLEIotrDw7227	rogid:P40LRIf+7tlgFm3u8nKwTHZw8IQ7227	intact-crc:1590413B321DC684|rigid:xY5gIZwWs9t4LQSokEo+nt1OXdE	false	glutathione s tranferase tag:?-?|sufficient binding region:29-48	35s radiolabel:?-?	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q9V8P9	uniprotkb:P30189	intact:EBI-147805|ensemblmetazoa:FBpp0085754|ensemblmetazoa:FBpp0304302	intact:EBI-108030|uniprotkb:Q9VXW6	psi-mi:toprs_drome(display_long)|uniprotkb:Topors(gene name)|psi-mi:Topors(display_short)|uniprotkb:dTopors(gene name synonym)|uniprotkb:SUMO1-protein E3 ligase Topors(gene name synonym)|uniprotkb:Topoisomerase I-binding RING finger protein(gene name synonym)|uniprotkb:Topoisomerase I-binding arginine/serine-rich protein(gene name synonym)|uniprotkb:CG15104(orf name)|uniprotkb:RING-type E3 ubiquitin transferase Topors(gene name synonym)	psi-mi:top1_drome(display_long)|uniprotkb:DNA topoisomerase I(gene name synonym)|uniprotkb:Top1(gene name)|psi-mi:Top1(display_short)|uniprotkb:CG6146(orf name)	psi-mi:"MI:0096"(pull down)	Secombe et al. (2004)	pubmed:14871887|imex:IM-19298	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2295664|imex:IM-19298-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	flybase:FBgn0267351|refseq:NP_611388.1|refseq:NP_001261083.1|ensemblmetazoa:FBgn0267351(gene)|ensemblmetazoa:FBtr0086570(transcript)|ensemblmetazoa:FBtr0331977(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005700"(polytene chromosome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0006325"(chromatin organization)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006997"(nucleus organization)|go:"GO:0007060"(male meiosis chromosome segregation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0016558"(protein import into peroxisome matrix)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0051299"(centrosome separation)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0071763"(nuclear membrane organization)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957	refseq:NP_001014742.1|refseq:NP_511161.2|flybase:FBgn0004924|go:"GO:0000791"(euchromatin)|go:"GO:0002168"(instar larval development)|go:"GO:0003677"(DNA binding)|go:"GO:0003916"(DNA topoisomerase activity)|go:"GO:0003917"("DNA topoisomerase type I (single strand cut, ATP-independent) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005700"(polytene chromosome)|go:"GO:0005703"(polytene chromosome puff)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006265"(DNA topological change)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007275"(multicellular organism development)|go:"GO:0030261"(chromosome condensation)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0048477"(oogenesis)|interpro:IPR001631(DNA topoisomerase I, C-terminal)|interpro:IPR008336(DNA topoisomerase I, DNA binding, eukaryotic-type)|interpro:IPR011010(DNA breaking-rejoining enzyme, catalytic core)|interpro:IPR013030(DNA topoisomerase I, DNA binding, mixed alpha/beta motif, eukaryotic-type)|interpro:IPR013034(DNA topoisomerase I, DNA binding, alpha helical motif, eukaryotic-type)|interpro:IPR013499(DNA topoisomerase I, C-terminal, eukaryotic-type)|interpro:IPR013500(DNA topoisomerase I, catalytic core, eukaryotic-type)|interpro:IPR014711(DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type)|interpro:IPR014727(DNA topoisomerase I, catalytic core, alpha/beta subdomain, eukaryotic-type)|interpro:IPR018521|interpro:IPR025834|interpro:IPR036202	-	-	-	figure legend:1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/03/25	2014/10/16	rogid:P40LRIf+7tlgFm3u8nKwTHZw8IQ7227	rogid:DC7+Gt/QVssiqJ7ilInwWDXM4zg7227	intact-crc:F754F57ECB1CBDE2|rigid:XcvUGsL83f4OcGA4r41ChO5qb3I	false	35s radiolabel:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q9V8P9	uniprotkb:Q9N6D8	intact:EBI-147805|ensemblmetazoa:FBpp0085754|ensemblmetazoa:FBpp0304302	intact:EBI-122286|uniprotkb:Q9VCR8|ensemblmetazoa:FBpp0083752|ensemblmetazoa:FBpp0290979	psi-mi:toprs_drome(display_long)|uniprotkb:Topors(gene name)|psi-mi:Topors(display_short)|uniprotkb:dTopors(gene name synonym)|uniprotkb:SUMO1-protein E3 ligase Topors(gene name synonym)|uniprotkb:Topoisomerase I-binding RING finger protein(gene name synonym)|uniprotkb:Topoisomerase I-binding arginine/serine-rich protein(gene name synonym)|uniprotkb:CG15104(orf name)|uniprotkb:RING-type E3 ubiquitin transferase Topors(gene name synonym)	psi-mi:q9n6d8_drome(display_long)|uniprotkb:p53(gene name)|psi-mi:p53(display_short)|uniprotkb:prac(gene name synonym)|uniprotkb:Dmel_CG33336(orf name)|uniprotkb:CG10873(gene name synonym)|uniprotkb:CG31325(gene name synonym)|uniprotkb:CG33336(orf name)|uniprotkb:D-p53(gene name synonym)|uniprotkb:DMP53(gene name synonym)|uniprotkb:Dm-P53(gene name synonym)|uniprotkb:DmP53(gene name synonym)|uniprotkb:Dmel\CG33336(gene name synonym)|uniprotkb:Dmp53(gene name synonym)|uniprotkb:Dp53(gene name synonym)|uniprotkb:dmp53(gene name synonym)|uniprotkb:dp53(gene name synonym)|uniprotkb:P53(gene name synonym)|uniprotkb:dmP53(gene name synonym)	psi-mi:"MI:0096"(pull down)	Secombe et al. (2004)	pubmed:14871887|imex:IM-19298	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2295672|imex:IM-19298-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	flybase:FBgn0267351|refseq:NP_611388.1|refseq:NP_001261083.1|ensemblmetazoa:FBgn0267351(gene)|ensemblmetazoa:FBtr0086570(transcript)|ensemblmetazoa:FBtr0331977(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005700"(polytene chromosome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0006325"(chromatin organization)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006997"(nucleus organization)|go:"GO:0007060"(male meiosis chromosome segregation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0016558"(protein import into peroxisome matrix)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0051299"(centrosome separation)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0071763"(nuclear membrane organization)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957	refseq:NP_001163694.1|refseq:NP_996268.1|flybase:FBgn0039044|ensemblmetazoa:FBgn0039044(gene)|ensemblmetazoa:FBtr0084359(transcript)|ensemblmetazoa:FBtr0301765(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:2000685"(positive regulation of cellular response to X-ray)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR024631|interpro:IPR038163|go:"GO:1990248"(regulation of transcription from RNA polymerase II promoter in response to DNA damage)|go:"GO:0005634"(nucleus)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008219"(cell death)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009314"(response to radiation)|go:"GO:0009411"(response to UV)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0014016"(neuroblast differentiation)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0001097"(TFIIH-class transcription factor complex binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0040010"(positive regulation of growth rate)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043553"(negative regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043568"(positive regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0048477"(oogenesis)|go:"GO:0060785"(regulation of apoptosis involved in tissue homeostasis)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)	-	-	-	figure legend:1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/03/25	2014/10/16	rogid:P40LRIf+7tlgFm3u8nKwTHZw8IQ7227	rogid:ll0s+p54wBZXphYDnsuWODy5wmM7227	intact-crc:1C4D89F21F1ABC48|rigid:H3jGzr4HwwVFcr1ffDk99EYQ/xE	false	35s radiolabel:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q9V8P9	uniprotkb:P14003	intact:EBI-147805|ensemblmetazoa:FBpp0085754|ensemblmetazoa:FBpp0304302	intact:EBI-123011|intact:EBI-1639662|uniprotkb:A4V1N7|uniprotkb:Q95NH3|uniprotkb:Q95NU9|uniprotkb:Q9VSN8|ensemblmetazoa:FBpp0076296|ensemblmetazoa:FBpp0099504	psi-mi:toprs_drome(display_long)|uniprotkb:Topors(gene name)|psi-mi:Topors(display_short)|uniprotkb:dTopors(gene name synonym)|uniprotkb:SUMO1-protein E3 ligase Topors(gene name synonym)|uniprotkb:Topoisomerase I-binding RING finger protein(gene name synonym)|uniprotkb:Topoisomerase I-binding arginine/serine-rich protein(gene name synonym)|uniprotkb:CG15104(orf name)|uniprotkb:RING-type E3 ubiquitin transferase Topors(gene name synonym)	psi-mi:hair_drome(display_long)|uniprotkb:CG6494(orf name)|uniprotkb:h(gene name)|psi-mi:h(display_short)	psi-mi:"MI:0096"(pull down)	Secombe et al. (2004)	pubmed:14871887|imex:IM-19298	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2295719|imex:IM-19298-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	flybase:FBgn0267351|refseq:NP_611388.1|refseq:NP_001261083.1|ensemblmetazoa:FBgn0267351(gene)|ensemblmetazoa:FBtr0086570(transcript)|ensemblmetazoa:FBtr0331977(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005700"(polytene chromosome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0006325"(chromatin organization)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006997"(nucleus organization)|go:"GO:0007060"(male meiosis chromosome segregation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0016558"(protein import into peroxisome matrix)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0051299"(centrosome separation)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0071763"(nuclear membrane organization)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957	refseq:NP_001014577.1|refseq:NP_523977.2|flybase:FBgn0001168|ensemblmetazoa:FBgn0001168(gene)|ensemblmetazoa:FBtr0076569(transcript)|ensemblmetazoa:FBtr0100153(transcript)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0035290"(trunk segmentation)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0061024"(membrane organization)|go:"GO:0070888"(E-box binding)|interpro:IPR003650(Orange)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|mint:P14003|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007366"(periodic partitioning by pair rule gene)|go:"GO:0007399"(nervous system development)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0031323"(regulation of cellular metabolic process)|go:"GO:0035239"(tube morphogenesis)|go:"GO:0035289"(posterior head segmentation)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|dip:DIP-637N	-	-	-	figure legend:1A, 3A, 3C, 3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/03/25	2014/10/16	rogid:P40LRIf+7tlgFm3u8nKwTHZw8IQ7227	rogid:bO023bTsk72HhqvmgSjLEIotrDw7227	intact-crc:F01F6D75801B4B40|rigid:xY5gIZwWs9t4LQSokEo+nt1OXdE	false	sufficient binding region:495-682|35s radiolabel:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:P14003	uniprotkb:P14003	intact:EBI-123011|intact:EBI-1639662|uniprotkb:A4V1N7|uniprotkb:Q95NH3|uniprotkb:Q95NU9|uniprotkb:Q9VSN8|ensemblmetazoa:FBpp0076296|ensemblmetazoa:FBpp0099504	intact:EBI-123011|intact:EBI-1639662|uniprotkb:A4V1N7|uniprotkb:Q95NH3|uniprotkb:Q95NU9|uniprotkb:Q9VSN8|ensemblmetazoa:FBpp0076296|ensemblmetazoa:FBpp0099504	psi-mi:hair_drome(display_long)|uniprotkb:CG6494(orf name)|uniprotkb:h(gene name)|psi-mi:h(display_short)	psi-mi:hair_drome(display_long)|uniprotkb:CG6494(orf name)|uniprotkb:h(gene name)|psi-mi:h(display_short)	psi-mi:"MI:0096"(pull down)	Secombe et al. (2004)	pubmed:14871887|imex:IM-19298	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2295731|imex:IM-19298-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001014577.1|refseq:NP_523977.2|flybase:FBgn0001168|ensemblmetazoa:FBgn0001168(gene)|ensemblmetazoa:FBtr0076569(transcript)|ensemblmetazoa:FBtr0100153(transcript)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0035290"(trunk segmentation)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0061024"(membrane organization)|go:"GO:0070888"(E-box binding)|interpro:IPR003650(Orange)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|mint:P14003|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007366"(periodic partitioning by pair rule gene)|go:"GO:0007399"(nervous system development)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0031323"(regulation of cellular metabolic process)|go:"GO:0035239"(tube morphogenesis)|go:"GO:0035289"(posterior head segmentation)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|dip:DIP-637N	refseq:NP_001014577.1|refseq:NP_523977.2|flybase:FBgn0001168|ensemblmetazoa:FBgn0001168(gene)|ensemblmetazoa:FBtr0076569(transcript)|ensemblmetazoa:FBtr0100153(transcript)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0035290"(trunk segmentation)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0061024"(membrane organization)|go:"GO:0070888"(E-box binding)|interpro:IPR003650(Orange)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|mint:P14003|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007366"(periodic partitioning by pair rule gene)|go:"GO:0007399"(nervous system development)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0031323"(regulation of cellular metabolic process)|go:"GO:0035239"(tube morphogenesis)|go:"GO:0035289"(posterior head segmentation)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|dip:DIP-637N	-	-	-	figure legend:3C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/03/25	2014/10/16	rogid:bO023bTsk72HhqvmgSjLEIotrDw7227	rogid:bO023bTsk72HhqvmgSjLEIotrDw7227	intact-crc:73CC69D8E52CE715|rigid:jX/jndo4EJktljQnFGGddzKOeqo	false	glutathione s tranferase tag:?-?	35s radiolabel:?-?	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:P13098	uniprotkb:P14003	intact:EBI-185388|intact:EBI-1639218|uniprotkb:Q9VBI5|uniprotkb:Q0IGQ3|uniprotkb:Q2XYK0|uniprotkb:Q5S426|uniprotkb:Q5S462|uniprotkb:Q5S474|uniprotkb:Q5S4H0|uniprotkb:Q5S4I2|ensemblmetazoa:FBpp0084335	intact:EBI-123011|intact:EBI-1639662|uniprotkb:A4V1N7|uniprotkb:Q95NH3|uniprotkb:Q95NU9|uniprotkb:Q9VSN8|ensemblmetazoa:FBpp0076296|ensemblmetazoa:FBpp0099504	psi-mi:esm8_drome(display_long)|uniprotkb:"E(spl)m8-HLH"(gene name)|psi-mi:"E(spl)m8-HLH"(display_short)|uniprotkb:"E(spl)"(gene name synonym)|uniprotkb:m8(gene name synonym)|uniprotkb:CG8365(orf name)	psi-mi:hair_drome(display_long)|uniprotkb:CG6494(orf name)|uniprotkb:h(gene name)|psi-mi:h(display_short)	psi-mi:"MI:0096"(pull down)	Secombe et al. (2004)	pubmed:14871887|imex:IM-19298	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2295740|imex:IM-19298-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_524513.1|flybase:FBgn0000591|dip:DIP-22511N|ensemblmetazoa:FBgn0000591(gene)|ensemblmetazoa:FBtr0084961(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007498"(mesoderm development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016360"(sensory organ precursor cell fate determination)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048749"(compound eye development)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050767"(regulation of neurogenesis)|interpro:IPR003650(Orange)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638	refseq:NP_001014577.1|refseq:NP_523977.2|flybase:FBgn0001168|ensemblmetazoa:FBgn0001168(gene)|ensemblmetazoa:FBtr0076569(transcript)|ensemblmetazoa:FBtr0100153(transcript)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0035290"(trunk segmentation)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0061024"(membrane organization)|go:"GO:0070888"(E-box binding)|interpro:IPR003650(Orange)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|mint:P14003|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007366"(periodic partitioning by pair rule gene)|go:"GO:0007399"(nervous system development)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0031323"(regulation of cellular metabolic process)|go:"GO:0035239"(tube morphogenesis)|go:"GO:0035289"(posterior head segmentation)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|dip:DIP-637N	-	-	-	figure legend:3C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/03/25	2014/10/16	rogid:Ytd8Ad4FJAfx25V7mHNi9e+F0pw7227	rogid:bO023bTsk72HhqvmgSjLEIotrDw7227	intact-crc:1CDC614ABCEEF14C|rigid:ztF/ybfEKMVv6pwQDV5nZJN1IQk	false	glutathione s tranferase tag:?-?	35s radiolabel:?-?	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q01068	uniprotkb:P14003	intact:EBI-121622|intact:EBI-1639233|uniprotkb:Q5S455|uniprotkb:Q5S479|uniprotkb:Q5S4J9|ensemblmetazoa:FBpp0084332	intact:EBI-123011|intact:EBI-1639662|uniprotkb:A4V1N7|uniprotkb:Q95NH3|uniprotkb:Q95NU9|uniprotkb:Q9VSN8|ensemblmetazoa:FBpp0076296|ensemblmetazoa:FBpp0099504	psi-mi:esm3_drome(display_long)|uniprotkb:"E(spl)m3-HLH"(gene name)|psi-mi:"E(spl)m3-HLH"(display_short)|uniprotkb:HLH-m3(gene name synonym)|uniprotkb:HLHm3(gene name synonym)|uniprotkb:CG8346(orf name)	psi-mi:hair_drome(display_long)|uniprotkb:CG6494(orf name)|uniprotkb:h(gene name)|psi-mi:h(display_short)	psi-mi:"MI:0096"(pull down)	Secombe et al. (2004)	pubmed:14871887|imex:IM-19298	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2295749|imex:IM-19298-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_524509.2|flybase:FBgn0002609|ensemblmetazoa:FBgn0002609(gene)|ensemblmetazoa:FBtr0084958(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR003650(Orange)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|dip:DIP-356N	refseq:NP_001014577.1|refseq:NP_523977.2|flybase:FBgn0001168|ensemblmetazoa:FBgn0001168(gene)|ensemblmetazoa:FBtr0076569(transcript)|ensemblmetazoa:FBtr0100153(transcript)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0035290"(trunk segmentation)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0061024"(membrane organization)|go:"GO:0070888"(E-box binding)|interpro:IPR003650(Orange)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|mint:P14003|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007366"(periodic partitioning by pair rule gene)|go:"GO:0007399"(nervous system development)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0031323"(regulation of cellular metabolic process)|go:"GO:0035239"(tube morphogenesis)|go:"GO:0035289"(posterior head segmentation)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|dip:DIP-637N	-	-	-	figure legend:3C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/03/25	2014/10/16	rogid:vUARbH3KdgSIFXpoweFPo1Di0vk7227	rogid:bO023bTsk72HhqvmgSjLEIotrDw7227	intact-crc:402BE86D3230CDA6|rigid:/9KO/3kt2eOK2Sg2kE427VTEpj0	false	glutathione s tranferase tag:?-?	35s radiolabel:?-?	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:P14003	uniprotkb:Q26263	intact:EBI-123011|intact:EBI-1639662|uniprotkb:A4V1N7|uniprotkb:Q95NH3|uniprotkb:Q95NU9|uniprotkb:Q9VSN8|ensemblmetazoa:FBpp0076296|ensemblmetazoa:FBpp0099504	intact:EBI-144502|uniprotkb:Q9V384|ensemblmetazoa:FBpp0087879	psi-mi:hair_drome(display_long)|uniprotkb:CG6494(orf name)|uniprotkb:h(gene name)|psi-mi:h(display_short)	psi-mi:dpn_drome(display_long)|uniprotkb:dpn(gene name)|psi-mi:dpn(display_short)|uniprotkb:CG8704(orf name)	psi-mi:"MI:0096"(pull down)	Secombe et al. (2004)	pubmed:14871887|imex:IM-19298	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2295758|imex:IM-19298-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001014577.1|refseq:NP_523977.2|flybase:FBgn0001168|ensemblmetazoa:FBgn0001168(gene)|ensemblmetazoa:FBtr0076569(transcript)|ensemblmetazoa:FBtr0100153(transcript)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0035290"(trunk segmentation)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0061024"(membrane organization)|go:"GO:0070888"(E-box binding)|interpro:IPR003650(Orange)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|mint:P14003|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007366"(periodic partitioning by pair rule gene)|go:"GO:0007399"(nervous system development)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0031323"(regulation of cellular metabolic process)|go:"GO:0035239"(tube morphogenesis)|go:"GO:0035289"(posterior head segmentation)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|dip:DIP-637N	refseq:NP_476923.1|flybase:FBgn0010109|dip:DIP-19436N|ensemblmetazoa:FBgn0010109(gene)|ensemblmetazoa:FBtr0088803(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007540"("sex determination, establishment of X:A ratio")|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR003650(Orange)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|go:"GO:0007549"(dosage compensation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008345"(larval locomotory behavior)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014019"(neuroblast development)|go:"GO:0043565"(sequence-specific DNA binding)	-	-	-	figure legend:3C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/03/25	2014/10/16	rogid:bO023bTsk72HhqvmgSjLEIotrDw7227	rogid:U1CUdm2K6ZYMRIRNp8diHtOZAX87227	intact-crc:FA7F502DA366CAF7|rigid:lxpPfxBptea6F72QnsMeGmYrt94	false	35s radiolabel:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q9V8P9	uniprotkb:P14003	intact:EBI-147805|ensemblmetazoa:FBpp0085754|ensemblmetazoa:FBpp0304302	intact:EBI-123011|intact:EBI-1639662|uniprotkb:A4V1N7|uniprotkb:Q95NH3|uniprotkb:Q95NU9|uniprotkb:Q9VSN8|ensemblmetazoa:FBpp0076296|ensemblmetazoa:FBpp0099504	psi-mi:toprs_drome(display_long)|uniprotkb:Topors(gene name)|psi-mi:Topors(display_short)|uniprotkb:dTopors(gene name synonym)|uniprotkb:SUMO1-protein E3 ligase Topors(gene name synonym)|uniprotkb:Topoisomerase I-binding RING finger protein(gene name synonym)|uniprotkb:Topoisomerase I-binding arginine/serine-rich protein(gene name synonym)|uniprotkb:CG15104(orf name)|uniprotkb:RING-type E3 ubiquitin transferase Topors(gene name synonym)	psi-mi:hair_drome(display_long)|uniprotkb:CG6494(orf name)|uniprotkb:h(gene name)|psi-mi:h(display_short)	psi-mi:"MI:0096"(pull down)	Secombe et al. (2004)	pubmed:14871887|imex:IM-19298	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2295684|imex:IM-19298-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	flybase:FBgn0267351|refseq:NP_611388.1|refseq:NP_001261083.1|ensemblmetazoa:FBgn0267351(gene)|ensemblmetazoa:FBtr0086570(transcript)|ensemblmetazoa:FBtr0331977(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005700"(polytene chromosome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0006325"(chromatin organization)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006997"(nucleus organization)|go:"GO:0007060"(male meiosis chromosome segregation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0016558"(protein import into peroxisome matrix)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0051299"(centrosome separation)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0071763"(nuclear membrane organization)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957	refseq:NP_001014577.1|refseq:NP_523977.2|flybase:FBgn0001168|ensemblmetazoa:FBgn0001168(gene)|ensemblmetazoa:FBtr0076569(transcript)|ensemblmetazoa:FBtr0100153(transcript)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0035290"(trunk segmentation)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0061024"(membrane organization)|go:"GO:0070888"(E-box binding)|interpro:IPR003650(Orange)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|mint:P14003|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007366"(periodic partitioning by pair rule gene)|go:"GO:0007399"(nervous system development)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0031323"(regulation of cellular metabolic process)|go:"GO:0035239"(tube morphogenesis)|go:"GO:0035289"(posterior head segmentation)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|dip:DIP-637N	-	-	-	figure legend:1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/03/25	2014/10/16	rogid:P40LRIf+7tlgFm3u8nKwTHZw8IQ7227	rogid:bO023bTsk72HhqvmgSjLEIotrDw7227	intact-crc:CE962BE82083D797|rigid:xY5gIZwWs9t4LQSokEo+nt1OXdE	false	his tag:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P14003	uniprotkb:Q9V8P9	intact:EBI-123011|intact:EBI-1639662|uniprotkb:A4V1N7|uniprotkb:Q95NH3|uniprotkb:Q95NU9|uniprotkb:Q9VSN8|ensemblmetazoa:FBpp0076296|ensemblmetazoa:FBpp0099504	intact:EBI-147805|ensemblmetazoa:FBpp0085754|ensemblmetazoa:FBpp0304302	psi-mi:hair_drome(display_long)|uniprotkb:CG6494(orf name)|uniprotkb:h(gene name)|psi-mi:h(display_short)	psi-mi:toprs_drome(display_long)|uniprotkb:Topors(gene name)|psi-mi:Topors(display_short)|uniprotkb:dTopors(gene name synonym)|uniprotkb:SUMO1-protein E3 ligase Topors(gene name synonym)|uniprotkb:Topoisomerase I-binding RING finger protein(gene name synonym)|uniprotkb:Topoisomerase I-binding arginine/serine-rich protein(gene name synonym)|uniprotkb:CG15104(orf name)|uniprotkb:RING-type E3 ubiquitin transferase Topors(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Secombe et al. (2004)	pubmed:14871887|imex:IM-19298	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2295701|imex:IM-19298-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001014577.1|refseq:NP_523977.2|flybase:FBgn0001168|ensemblmetazoa:FBgn0001168(gene)|ensemblmetazoa:FBtr0076569(transcript)|ensemblmetazoa:FBtr0100153(transcript)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0035290"(trunk segmentation)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0061024"(membrane organization)|go:"GO:0070888"(E-box binding)|interpro:IPR003650(Orange)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|mint:P14003|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007366"(periodic partitioning by pair rule gene)|go:"GO:0007399"(nervous system development)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0031323"(regulation of cellular metabolic process)|go:"GO:0035239"(tube morphogenesis)|go:"GO:0035289"(posterior head segmentation)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|dip:DIP-637N	flybase:FBgn0267351|refseq:NP_611388.1|refseq:NP_001261083.1|ensemblmetazoa:FBgn0267351(gene)|ensemblmetazoa:FBtr0086570(transcript)|ensemblmetazoa:FBtr0331977(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005700"(polytene chromosome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0006325"(chromatin organization)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006997"(nucleus organization)|go:"GO:0007060"(male meiosis chromosome segregation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0016558"(protein import into peroxisome matrix)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0051299"(centrosome separation)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0071763"(nuclear membrane organization)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957	-	-	-	figure legend:1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/03/25	2014/10/16	rogid:bO023bTsk72HhqvmgSjLEIotrDw7227	rogid:P40LRIf+7tlgFm3u8nKwTHZw8IQ7227	intact-crc:5A7043F21CCA3A10|rigid:xY5gIZwWs9t4LQSokEo+nt1OXdE	false	myc tag:?-?	tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)