#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q07540	uniprotkb:Q03020	intact:EBI-2206814|uniprotkb:D6VRN0|ensemblfungi:YDL120W	intact:EBI-29901|uniprotkb:D6W3N2|ensemblfungi:YPL135W	psi-mi:frda_yeast(display_long)|uniprotkb:YFH1(gene name)|psi-mi:YFH1(display_short)|uniprotkb:YDL120W(locus name)	psi-mi:isu1_yeast(display_long)|uniprotkb:YPL135W(locus name)|uniprotkb:Iron sulfur cluster scaffold protein 1(gene name synonym)|uniprotkb:ISU1(gene name)|psi-mi:ISU1(display_short)|uniprotkb:NUA1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Gerber et al. (2003)	pubmed:12947415|imex:IM-20231	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2206835|imex:IM-20231-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-7485N|refseq:NP_010163.1|sgd:S000002278|mint:Q07540|ensemblfungi:YDL120W(gene)|ensemblfungi:YDL120W_mRNA(transcript)|go:"GO:0004322"(ferroxidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006121"(mitochondrial electron transport, succinate to ubiquinone)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0006811"(ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008199"(ferric iron binding)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0018283"(iron incorporation into metallo-sulfur cluster)|go:"GO:0034986"(iron chaperone activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|interpro:IPR002908(Frataxin-like)|interpro:IPR017789(Frataxin)|interpro:IPR020895|interpro:IPR036524|rcsb pdb:2FQL|rcsb pdb:2GA5|rcsb pdb:3OEQ|rcsb pdb:3OER|rcsb pdb:4EC2|rcsb pdb:5T0V|rcsb pdb:5TRE|reactome:R-SCE-1268020|reactome:R-SCE-1362409|go:"GO:0008198"(ferrous iron binding)	refseq:NP_015190.1|sgd:S000006056|dip:DIP-6556N|mint:Q03020|ensemblfungi:YPL135W(gene)|ensemblfungi:YPL135W_mRNA(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0002098"(tRNA wobble uridine modification)|go:"GO:0005506"(iron ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR002871(NIF system FeS cluster assembly, NifU, N-terminal)|interpro:IPR011339(ISC system FeS cluster assembly, IscU scaffold)|rcsb pdb:5T0V|rcsb pdb:5TRE|reactome:R-SCE-1362409	go:"GO:0005739"(mitochondrion)	crc64:AB1FF7478EF0E5D6	crc64:E240845A27D2E9EE	figure legend:Fig. 1A Fig. 4|agonist:Fe2+|antagonist:EDTA divalent metal chelator|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/01/15	2014/10/16	rogid:4UcroTodEXb/5+xHGpnXDXf/rd8559292	rogid:zpPseOgZoK3cF+mCetzw05ct9Kc559292	intact-crc:0D77560200F08D9A|rigid:F6hLcty9OAzuo8fJWgTYzhOunDM	false	glutathione s tranferase tag:n-n|sufficient binding region:52-174	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q07540	uniprotkb:P25374	intact:EBI-2206814|uniprotkb:D6VRN0|ensemblfungi:YDL120W	intact:EBI-11991|ensemblfungi:YCL017C|uniprotkb:D6VQZ7	psi-mi:frda_yeast(display_long)|uniprotkb:YFH1(gene name)|psi-mi:YFH1(display_short)|uniprotkb:YDL120W(locus name)	psi-mi:nfs1_yeast(display_long)|uniprotkb:NFS1(gene name)|psi-mi:NFS1(display_short)|uniprotkb:SPL1(gene name synonym)|uniprotkb:YCL017C(locus name)|uniprotkb:tRNA-splicing protein SPL1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Gerber et al. (2003)	pubmed:12947415|imex:IM-20231	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2206835|imex:IM-20231-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-7485N|refseq:NP_010163.1|sgd:S000002278|mint:Q07540|ensemblfungi:YDL120W(gene)|ensemblfungi:YDL120W_mRNA(transcript)|go:"GO:0004322"(ferroxidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006121"(mitochondrial electron transport, succinate to ubiquinone)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0006811"(ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008199"(ferric iron binding)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0018283"(iron incorporation into metallo-sulfur cluster)|go:"GO:0034986"(iron chaperone activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|interpro:IPR002908(Frataxin-like)|interpro:IPR017789(Frataxin)|interpro:IPR020895|interpro:IPR036524|rcsb pdb:2FQL|rcsb pdb:2GA5|rcsb pdb:3OEQ|rcsb pdb:3OER|rcsb pdb:4EC2|rcsb pdb:5T0V|rcsb pdb:5TRE|reactome:R-SCE-1268020|reactome:R-SCE-1362409|go:"GO:0008198"(ferrous iron binding)	ensemblfungi:YCL017C(gene)|ensemblfungi:YCL017C_mRNA(transcript)|go:"GO:0002098"(tRNA wobble uridine modification)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0031071"(cysteine desulfurase activity)|go:"GO:0034227"(tRNA thio-modification)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051536"(iron-sulfur cluster binding)|go:"GO:0070903"(mitochondrial tRNA thio-modification)|interpro:IPR000192(Aminotransferase, class V/Cysteine desulphurase)|interpro:IPR010240(Cysteine desulphurase)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|interpro:IPR020578|reactome:R-SCE-1362409|reactome:R-SCE-947581|go:"GO:1990221"(L-cysteine desulfurase complex)|refseq:NP_009912.2|sgd:S000000522|mint:P25374|dip:DIP-2948N	go:"GO:0005739"(mitochondrion)	crc64:AB1FF7478EF0E5D6	crc64:D709E326B3921BCC	figure legend:Fig. 1A Fig. 4|agonist:Fe2+|antagonist:EDTA divalent metal chelator|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/01/15	2014/10/16	rogid:4UcroTodEXb/5+xHGpnXDXf/rd8559292	rogid:Hko+QCpE9h22e3m1UVFDUSwpSSw559292	intact-crc:0D77560200F08D9A|rigid:F6hLcty9OAzuo8fJWgTYzhOunDM	false	glutathione s tranferase tag:n-n|sufficient binding region:52-174	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q03020	uniprotkb:P25374	intact:EBI-29901|uniprotkb:D6W3N2|ensemblfungi:YPL135W	intact:EBI-11991|ensemblfungi:YCL017C|uniprotkb:D6VQZ7	psi-mi:isu1_yeast(display_long)|uniprotkb:YPL135W(locus name)|uniprotkb:Iron sulfur cluster scaffold protein 1(gene name synonym)|uniprotkb:ISU1(gene name)|psi-mi:ISU1(display_short)|uniprotkb:NUA1(gene name synonym)	psi-mi:nfs1_yeast(display_long)|uniprotkb:NFS1(gene name)|psi-mi:NFS1(display_short)|uniprotkb:SPL1(gene name synonym)|uniprotkb:YCL017C(locus name)|uniprotkb:tRNA-splicing protein SPL1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Gerber et al. (2003)	pubmed:12947415|imex:IM-20231	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2206846|imex:IM-20231-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_015190.1|sgd:S000006056|dip:DIP-6556N|mint:Q03020|ensemblfungi:YPL135W(gene)|ensemblfungi:YPL135W_mRNA(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0002098"(tRNA wobble uridine modification)|go:"GO:0005506"(iron ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR002871(NIF system FeS cluster assembly, NifU, N-terminal)|interpro:IPR011339(ISC system FeS cluster assembly, IscU scaffold)|rcsb pdb:5T0V|rcsb pdb:5TRE|reactome:R-SCE-1362409	ensemblfungi:YCL017C(gene)|ensemblfungi:YCL017C_mRNA(transcript)|go:"GO:0002098"(tRNA wobble uridine modification)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0031071"(cysteine desulfurase activity)|go:"GO:0034227"(tRNA thio-modification)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051536"(iron-sulfur cluster binding)|go:"GO:0070903"(mitochondrial tRNA thio-modification)|interpro:IPR000192(Aminotransferase, class V/Cysteine desulphurase)|interpro:IPR010240(Cysteine desulphurase)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|interpro:IPR020578|reactome:R-SCE-1362409|reactome:R-SCE-947581|go:"GO:1990221"(L-cysteine desulfurase complex)|refseq:NP_009912.2|sgd:S000000522|mint:P25374|dip:DIP-2948N	go:"GO:0005739"(mitochondrion)	crc64:E240845A27D2E9EE	crc64:D709E326B3921BCC	figure legend:Figs. 2B and 4C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/01/15	2014/10/16	rogid:zpPseOgZoK3cF+mCetzw05ct9Kc559292	rogid:Hko+QCpE9h22e3m1UVFDUSwpSSw559292	intact-crc:03EBB85CA7220517|rigid:PwJBuHkckx3JH0RYQTS3yUh25xg	false	glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q03020	uniprotkb:Q07540	intact:EBI-29901|uniprotkb:D6W3N2|ensemblfungi:YPL135W	intact:EBI-2206814|uniprotkb:D6VRN0|ensemblfungi:YDL120W	psi-mi:isu1_yeast(display_long)|uniprotkb:YPL135W(locus name)|uniprotkb:Iron sulfur cluster scaffold protein 1(gene name synonym)|uniprotkb:ISU1(gene name)|psi-mi:ISU1(display_short)|uniprotkb:NUA1(gene name synonym)	psi-mi:frda_yeast(display_long)|uniprotkb:YFH1(gene name)|psi-mi:YFH1(display_short)|uniprotkb:YDL120W(locus name)	psi-mi:"MI:0096"(pull down)	Gerber et al. (2003)	pubmed:12947415|imex:IM-20231	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2206846|imex:IM-20231-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_015190.1|sgd:S000006056|dip:DIP-6556N|mint:Q03020|ensemblfungi:YPL135W(gene)|ensemblfungi:YPL135W_mRNA(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0002098"(tRNA wobble uridine modification)|go:"GO:0005506"(iron ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR002871(NIF system FeS cluster assembly, NifU, N-terminal)|interpro:IPR011339(ISC system FeS cluster assembly, IscU scaffold)|rcsb pdb:5T0V|rcsb pdb:5TRE|reactome:R-SCE-1362409	dip:DIP-7485N|refseq:NP_010163.1|sgd:S000002278|mint:Q07540|ensemblfungi:YDL120W(gene)|ensemblfungi:YDL120W_mRNA(transcript)|go:"GO:0004322"(ferroxidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006121"(mitochondrial electron transport, succinate to ubiquinone)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0006811"(ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008199"(ferric iron binding)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0018283"(iron incorporation into metallo-sulfur cluster)|go:"GO:0034986"(iron chaperone activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|interpro:IPR002908(Frataxin-like)|interpro:IPR017789(Frataxin)|interpro:IPR020895|interpro:IPR036524|rcsb pdb:2FQL|rcsb pdb:2GA5|rcsb pdb:3OEQ|rcsb pdb:3OER|rcsb pdb:4EC2|rcsb pdb:5T0V|rcsb pdb:5TRE|reactome:R-SCE-1268020|reactome:R-SCE-1362409|go:"GO:0008198"(ferrous iron binding)	go:"GO:0005739"(mitochondrion)	crc64:E240845A27D2E9EE	crc64:AB1FF7478EF0E5D6	figure legend:Figs. 2B and 4C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/01/15	2014/10/16	rogid:zpPseOgZoK3cF+mCetzw05ct9Kc559292	rogid:4UcroTodEXb/5+xHGpnXDXf/rd8559292	intact-crc:03EBB85CA7220517|rigid:PwJBuHkckx3JH0RYQTS3yUh25xg	false	glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q03020	uniprotkb:Q05931	intact:EBI-29901|uniprotkb:D6W3N2|ensemblfungi:YPL135W	intact:EBI-35227|uniprotkb:D6VZ06|ensemblfungi:YLR369W	psi-mi:isu1_yeast(display_long)|uniprotkb:YPL135W(locus name)|uniprotkb:Iron sulfur cluster scaffold protein 1(gene name synonym)|uniprotkb:ISU1(gene name)|psi-mi:ISU1(display_short)|uniprotkb:NUA1(gene name synonym)	psi-mi:hsp7q_yeast(display_long)|uniprotkb:SSQ1(gene name)|psi-mi:SSQ1(display_short)|uniprotkb:mtHSP70 homolog(gene name synonym)|uniprotkb:SSC2(gene name synonym)|uniprotkb:Stress-seventy subfamily Q protein 1(gene name synonym)|uniprotkb:YLR369W(locus name)|uniprotkb:Heat shock protein SSQ1, mitochondrial(gene name synonym)	psi-mi:"MI:0096"(pull down)	Gerber et al. (2003)	pubmed:12947415|imex:IM-20231	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2206846|imex:IM-20231-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_015190.1|sgd:S000006056|dip:DIP-6556N|mint:Q03020|ensemblfungi:YPL135W(gene)|ensemblfungi:YPL135W_mRNA(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0002098"(tRNA wobble uridine modification)|go:"GO:0005506"(iron ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR002871(NIF system FeS cluster assembly, NifU, N-terminal)|interpro:IPR011339(ISC system FeS cluster assembly, IscU scaffold)|rcsb pdb:5T0V|rcsb pdb:5TRE|reactome:R-SCE-1362409	refseq:NP_013473.1|sgd:S000004361|mint:Q05931|dip:DIP-6407N|ensemblfungi:YLR369W(gene)|ensemblfungi:YLR369W_mRNA(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|go:"GO:0106034"(protein maturation by [2Fe-2S] cluster transfer)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)	go:"GO:0005739"(mitochondrion)	crc64:E240845A27D2E9EE	crc64:AC2DF42F3D623892	figure legend:Figs. 2B and 4C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/01/15	2014/10/16	rogid:zpPseOgZoK3cF+mCetzw05ct9Kc559292	rogid:PGcPon176Ea5v+lmsUYk5y4yaZU559292	intact-crc:03EBB85CA7220517|rigid:PwJBuHkckx3JH0RYQTS3yUh25xg	false	glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q07540	uniprotkb:Q05931	intact:EBI-2206814|uniprotkb:D6VRN0|ensemblfungi:YDL120W	intact:EBI-35227|uniprotkb:D6VZ06|ensemblfungi:YLR369W	psi-mi:frda_yeast(display_long)|uniprotkb:YFH1(gene name)|psi-mi:YFH1(display_short)|uniprotkb:YDL120W(locus name)	psi-mi:hsp7q_yeast(display_long)|uniprotkb:SSQ1(gene name)|psi-mi:SSQ1(display_short)|uniprotkb:mtHSP70 homolog(gene name synonym)|uniprotkb:SSC2(gene name synonym)|uniprotkb:Stress-seventy subfamily Q protein 1(gene name synonym)|uniprotkb:YLR369W(locus name)|uniprotkb:Heat shock protein SSQ1, mitochondrial(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Gerber et al. (2003)	pubmed:12947415|imex:IM-20231	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2206863|imex:IM-20231-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-7485N|refseq:NP_010163.1|sgd:S000002278|mint:Q07540|ensemblfungi:YDL120W(gene)|ensemblfungi:YDL120W_mRNA(transcript)|go:"GO:0004322"(ferroxidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006121"(mitochondrial electron transport, succinate to ubiquinone)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0006811"(ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008199"(ferric iron binding)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0018283"(iron incorporation into metallo-sulfur cluster)|go:"GO:0034986"(iron chaperone activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|interpro:IPR002908(Frataxin-like)|interpro:IPR017789(Frataxin)|interpro:IPR020895|interpro:IPR036524|rcsb pdb:2FQL|rcsb pdb:2GA5|rcsb pdb:3OEQ|rcsb pdb:3OER|rcsb pdb:4EC2|rcsb pdb:5T0V|rcsb pdb:5TRE|reactome:R-SCE-1268020|reactome:R-SCE-1362409|go:"GO:0008198"(ferrous iron binding)	refseq:NP_013473.1|sgd:S000004361|mint:Q05931|dip:DIP-6407N|ensemblfungi:YLR369W(gene)|ensemblfungi:YLR369W_mRNA(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|go:"GO:0106034"(protein maturation by [2Fe-2S] cluster transfer)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)	go:"GO:0005739"(mitochondrion)	crc64:AB1FF7478EF0E5D6	crc64:AC2DF42F3D623892	figure legend:Figs. 3A and 3B|agonist:Fe2+|antagonist:EDTA divalent cation chealator|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/01/15	2014/10/16	rogid:4UcroTodEXb/5+xHGpnXDXf/rd8559292	rogid:PGcPon176Ea5v+lmsUYk5y4yaZU559292	intact-crc:06196BAA58C1F4AE|rigid:NassWgIMgT0hqh+GqPBo/mOhgLA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q07540	uniprotkb:Q03020	intact:EBI-2206814|uniprotkb:D6VRN0|ensemblfungi:YDL120W	intact:EBI-29901|uniprotkb:D6W3N2|ensemblfungi:YPL135W	psi-mi:frda_yeast(display_long)|uniprotkb:YFH1(gene name)|psi-mi:YFH1(display_short)|uniprotkb:YDL120W(locus name)	psi-mi:isu1_yeast(display_long)|uniprotkb:YPL135W(locus name)|uniprotkb:Iron sulfur cluster scaffold protein 1(gene name synonym)|uniprotkb:ISU1(gene name)|psi-mi:ISU1(display_short)|uniprotkb:NUA1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Gerber et al. (2003)	pubmed:12947415|imex:IM-20231	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2206863|imex:IM-20231-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-7485N|refseq:NP_010163.1|sgd:S000002278|mint:Q07540|ensemblfungi:YDL120W(gene)|ensemblfungi:YDL120W_mRNA(transcript)|go:"GO:0004322"(ferroxidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006121"(mitochondrial electron transport, succinate to ubiquinone)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0006811"(ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008199"(ferric iron binding)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0018283"(iron incorporation into metallo-sulfur cluster)|go:"GO:0034986"(iron chaperone activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|interpro:IPR002908(Frataxin-like)|interpro:IPR017789(Frataxin)|interpro:IPR020895|interpro:IPR036524|rcsb pdb:2FQL|rcsb pdb:2GA5|rcsb pdb:3OEQ|rcsb pdb:3OER|rcsb pdb:4EC2|rcsb pdb:5T0V|rcsb pdb:5TRE|reactome:R-SCE-1268020|reactome:R-SCE-1362409|go:"GO:0008198"(ferrous iron binding)	refseq:NP_015190.1|sgd:S000006056|dip:DIP-6556N|mint:Q03020|ensemblfungi:YPL135W(gene)|ensemblfungi:YPL135W_mRNA(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0002098"(tRNA wobble uridine modification)|go:"GO:0005506"(iron ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR002871(NIF system FeS cluster assembly, NifU, N-terminal)|interpro:IPR011339(ISC system FeS cluster assembly, IscU scaffold)|rcsb pdb:5T0V|rcsb pdb:5TRE|reactome:R-SCE-1362409	go:"GO:0005739"(mitochondrion)	crc64:AB1FF7478EF0E5D6	crc64:E240845A27D2E9EE	figure legend:Figs. 3A and 3B|agonist:Fe2+|antagonist:EDTA divalent cation chealator|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/01/15	2014/10/16	rogid:4UcroTodEXb/5+xHGpnXDXf/rd8559292	rogid:zpPseOgZoK3cF+mCetzw05ct9Kc559292	intact-crc:06196BAA58C1F4AE|rigid:NassWgIMgT0hqh+GqPBo/mOhgLA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
chebi:"CHEBI:18248"	uniprotkb:Q03020	intact:EBI-1252632	intact:EBI-29901|uniprotkb:D6W3N2|ensemblfungi:YPL135W	psi-mi:iron(display_short)|psi-mi:"CHEBI:18248"(display_long)	psi-mi:isu1_yeast(display_long)|uniprotkb:YPL135W(locus name)|uniprotkb:Iron sulfur cluster scaffold protein 1(gene name synonym)|uniprotkb:ISU1(gene name)|psi-mi:ISU1(display_short)|uniprotkb:NUA1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Gerber et al. (2003)	pubmed:12947415|imex:IM-20231	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2206878|imex:IM-20231-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_015190.1|sgd:S000006056|dip:DIP-6556N|mint:Q03020|ensemblfungi:YPL135W(gene)|ensemblfungi:YPL135W_mRNA(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0002098"(tRNA wobble uridine modification)|go:"GO:0005506"(iron ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR002871(NIF system FeS cluster assembly, NifU, N-terminal)|interpro:IPR011339(ISC system FeS cluster assembly, IscU scaffold)|rcsb pdb:5T0V|rcsb pdb:5TRE|reactome:R-SCE-1362409	go:"GO:0005506"(iron ion binding)	-	crc64:E240845A27D2E9EE	figure legend:Fig. 5|comment:Iron is radio-labelled|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/01/15	2014/10/16	-	rogid:zpPseOgZoK3cF+mCetzw05ct9Kc559292	intact-crc:FCA511FB80E230C2	false	-	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)