#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P05067	uniprotkb:Q92876	intact:EBI-77613|uniprotkb:P09000|uniprotkb:P78438|uniprotkb:Q13764|uniprotkb:Q13778|uniprotkb:Q13793|ensembl:ENSP00000284981|intact:EBI-28985182|uniprotkb:Q6GSC0|uniprotkb:Q8WZ99|uniprotkb:Q9UC33|uniprotkb:Q9UCC8|uniprotkb:Q9UCD1|uniprotkb:Q9UQ58|uniprotkb:Q16011|uniprotkb:Q16014|uniprotkb:Q16019|uniprotkb:Q16020|uniprotkb:Q9BT38|uniprotkb:Q9UCA9|uniprotkb:Q9UCB6|uniprotkb:B4DII8|uniprotkb:B2R5V1|uniprotkb:D3DSD1|uniprotkb:D3DSD2|uniprotkb:D3DSD3	intact:EBI-2432309|uniprotkb:A8MW09|uniprotkb:Q6H301|uniprotkb:A6NJA1|ensembl:ENSP00000309148|ensembl:ENSP00000366047|ensembl:ENSP00000470482	psi-mi:a4_human(display_long)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:klk6_human(display_long)|uniprotkb:PRSS9(gene name synonym)|uniprotkb:KLK6(gene name)|psi-mi:KLK6(display_short)|uniprotkb:PRSS18(gene name synonym)|uniprotkb:Protease M(gene name synonym)|uniprotkb:Neurosin(gene name synonym)|uniprotkb:Zyme(gene name synonym)|uniprotkb:SP59(gene name synonym)|uniprotkb:Serine protease 9(gene name synonym)|uniprotkb:Serine protease 18(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Magklara et al. (2003)	pubmed:12878203|imex:IM-20359	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2432334|imex:IM-20359-1	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0097645"(amylin binding)|go:"GO:0098815"(modulation of excitatory postsynaptic potential)|go:"GO:0106003"(amyloid-beta complex)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:1900122"(positive regulation of receptor binding)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1900221"(regulation of amyloid-beta clearance)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903048"(regulation of acetylcholine-gated cation channel activity)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904022"(positive regulation of G protein-coupled receptor internalization)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043235"(receptor complex)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044304"(main axon)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0046914"(transition metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|ensembl:ENST00000346798(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|ensembl:ENSG00000142192(gene)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001878"(response to yeast)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001967"(suckling behavior)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007155"(cell adhesion)|go:"GO:0007176"(regulation of epidermal growth factor-activated receptor activity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007611"(learning or memory)|go:"GO:0006897"(endocytosis)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007617"(mating behavior)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008088"(axo-dendritic transport)|go:"GO:0008201"(heparin binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0009987"(cellular process)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048669"(collateral sprouting in absence of injury)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050808"(synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050867"(positive regulation of cell activation)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0050890"(cognition)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051124"(synaptic assembly at neuromuscular junction)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0010823"(negative regulation of mitochondrion organization)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0014005"(microglia development)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016199"(axon midline choice point recognition)|go:"GO:0016322"(neuron remodeling)|go:"GO:0016358"(dendrite development)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019899"(enzyme binding)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030424"(axon)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0030549"(acetylcholine receptor activator activity)|go:"GO:0030900"(forebrain development)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031175"(neuron projection development)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034363"(intermediate-density lipoprotein particle)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0031904"(endosome lumen)|go:"GO:0051233"(spindle midzone)|go:"GO:0061903"(positive regulation of 1-phosphatidylinositol-3-kinase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0070206"(protein trimerization)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070381"(endosome to plasma membrane transport vesicle)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071874"(cellular response to norepinephrine stimulus)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0097449"(astrocyte projection)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051425"(PTB domain binding)|go:"GO:0051563"(smooth endoplasmic reticulum calcium ion homeostasis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:1904399"(heparan sulfate binding)|rcsb pdb:2LZ4|rcsb pdb:2M4J|rcsb pdb:2M9R|rcsb pdb:2M9S|rcsb pdb:2MGT|rcsb pdb:2MJ1|rcsb pdb:2MPZ|rcsb pdb:2MVX|rcsb pdb:2MXU|rcsb pdb:2NAO|interpro:IPR036880|interpro:IPR037071|rcsb pdb:2OTK|rcsb pdb:2R0W|rcsb pdb:2WK3|rcsb pdb:2Y29|mint:P05067|rcsb pdb:1AAP|rcsb pdb:1AMB|rcsb pdb:1AMC|rcsb pdb:1AML|rcsb pdb:1BA4|rcsb pdb:1BA6|rcsb pdb:1BJB|rcsb pdb:1BJC|rcsb pdb:1BRC|rcsb pdb:1CA0|rcsb pdb:1HZ3|rcsb pdb:1IYT|rcsb pdb:1MWP|rcsb pdb:1OWT|rcsb pdb:1QCM|rcsb pdb:1QWP|rcsb pdb:1QXC|rcsb pdb:1QYT|rcsb pdb:1TAW|rcsb pdb:1TKN|rcsb pdb:1UO7|rcsb pdb:1UO8|rcsb pdb:1UOA|rcsb pdb:1UOI|rcsb pdb:1X11|rcsb pdb:1Z0Q|rcsb pdb:1ZE7|rcsb pdb:1ZE9|rcsb pdb:1ZJD|rcsb pdb:2BEG|rcsb pdb:2BOM|rcsb pdb:2BP4|rcsb pdb:2FJZ|rcsb pdb:2FK1|rcsb pdb:2FK2|rcsb pdb:2FK3|rcsb pdb:2FKL|rcsb pdb:2FMA|rcsb pdb:2G47|rcsb pdb:2IPU|rcsb pdb:2LFM|rcsb pdb:2LLM|rcsb pdb:2LMN|rcsb pdb:2LMO|rcsb pdb:2LMP|rcsb pdb:2LMQ|rcsb pdb:2LNQ|rcsb pdb:2LOH|rcsb pdb:2LP1|rcsb pdb:2LZ3|rcsb pdb:2Y2A|rcsb pdb:2Y3J|rcsb pdb:2Y3K|rcsb pdb:2Y3L|rcsb pdb:3AYU|rcsb pdb:3BAE|rcsb pdb:3BKJ|rcsb pdb:3DXC|rcsb pdb:3DXD|rcsb pdb:3DXE|rcsb pdb:3GCI|rcsb pdb:3IFL|rcsb pdb:3IFN|rcsb pdb:3IFO|rcsb pdb:3IFP|rcsb pdb:3JQ5|rcsb pdb:3JQL|rcsb pdb:3JTI|rcsb pdb:3KTM|rcsb pdb:3L33|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904591"(positive regulation of protein import)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:1905893"(positive regulation of cellular response to thapsigargin)|go:"GO:1905896"(positive regulation of cellular response to tunicamycin)|go:"GO:1905898"(positive regulation of response to endoplasmic reticulum stress)|go:"GO:1905906"(regulation of amyloid fibril formation)|go:"GO:1905908"(positive regulation of amyloid fibril formation)|go:"GO:1905945"(regulation of response to calcium ion)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990535"(neuron projection maintenance)|go:"GO:1990761"(growth cone lamellipodium)|go:"GO:1990777"(lipoprotein particle)|go:"GO:1990812"(growth cone filopodium)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR002223(Proteinase inhibitor I2, Kunitz metazoa)|interpro:IPR008154(Amyloidogenic glycoprotein, extracellular)|interpro:IPR008155(Amyloidogenic glycoprotein, core)|interpro:IPR011178(Amyloidogenic glycoprotein, copper-binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013803(Amyloidogenic glycoprotein, amyloid-beta peptide)|interpro:IPR015849(Amyloidogenic glycoprotein, heparin-binding)|interpro:IPR019543|interpro:IPR019744|interpro:IPR019745|interpro:IPR020901|interpro:IPR024329|interpro:IPR028866|interpro:IPR036176|interpro:IPR036454|interpro:IPR036669|rcsb pdb:5HOY|rcsb pdb:5KK3|rcsb pdb:5LFY|rcsb pdb:5LV0|rcsb pdb:5MY4|rcsb pdb:5MYO|rcsb pdb:5MYX|rcsb pdb:5ONP|rcsb pdb:5ONQ|rcsb pdb:5OQV|rcsb pdb:5TXD|rcsb pdb:5VOS|rcsb pdb:5VZY|rcsb pdb:5W3P|rcsb pdb:6CO3|rcsb pdb:6GFI|rcsb pdb:6ITU|rcsb pdb:6IYC|rcsb pdb:6NB9|rcsb pdb:6O4J|rcsb pdb:6OC9|rcsb pdb:6OIZ|rcsb pdb:6RHY|rcsb pdb:6SHS|rcsb pdb:6SZF|rcsb pdb:6TI5|rcsb pdb:6TI6|rcsb pdb:6TI7|rcsb pdb:6W0O|rcsb pdb:6WXM|rcsb pdb:6YHF|rcsb pdb:6YHI|rcsb pdb:6YHO|rcsb pdb:6YHP|rcsb pdb:6YHX|rcsb pdb:7B3J|rcsb pdb:7B3K|rcsb pdb:7JXN|rcsb pdb:7JXO|rcsb pdb:7O1Q|reactome:R-HSA-114608|reactome:R-HSA-3000178|reactome:R-HSA-381426|reactome:R-HSA-416476|reactome:R-HSA-418594|reactome:R-HSA-432720|reactome:R-HSA-444473|reactome:R-HSA-445989|reactome:R-HSA-844456|reactome:R-HSA-879415|reactome:R-HSA-8862803|reactome:R-HSA-8957275|reactome:R-HSA-933542|reactome:R-HSA-9609523|reactome:R-HSA-9660826|reactome:R-HSA-977225|rcsb pdb:5AMB|rcsb pdb:5BUO|rcsb pdb:5C67|rcsb pdb:5CSZ|rcsb pdb:5HOW|rcsb pdb:5HOX|rcsb pdb:3L81|rcsb pdb:3MOQ|rcsb pdb:3MXC|rcsb pdb:3MXY|rcsb pdb:3NYJ|rcsb pdb:3NYL|rcsb pdb:3OVJ|rcsb pdb:3OW9|rcsb pdb:3PZZ|rcsb pdb:3Q2X|rcsb pdb:3SV1|rcsb pdb:3U0T|rcsb pdb:3UMH|rcsb pdb:3UMI|rcsb pdb:3UMK|rcsb pdb:4HIX|rcsb pdb:4JFN|rcsb pdb:4M1C|rcsb pdb:4MDR|rcsb pdb:4MVI|rcsb pdb:4MVK|rcsb pdb:4MVL|rcsb pdb:4NGE|rcsb pdb:4OJF|rcsb pdb:4ONF|rcsb pdb:4ONG|rcsb pdb:4PQD|rcsb pdb:4PWQ|rcsb pdb:4XXD|rcsb pdb:5AEF|rcsb pdb:5AM8|refseq:NP_000475.1|refseq:NP_001129601.1|refseq:NP_001129602.1|refseq:NP_001191230.1|refseq:NP_001191231.1|refseq:NP_001191232.1|refseq:NP_958816.1|refseq:NP_958817.1|ensembl:ENSP00000284981|ensembl:ENST00000348990|ensembl:ENSP00000345463|ensembl:ENST00000354192|ensembl:ENSP00000346129|ensembl:ENST00000357903|ensembl:ENSP00000350578|ensembl:ENST00000358918|ensembl:ENSP00000351796|ensembl:ENST00000440126|ensembl:ENSP00000387483|refseq:NP_001129488.1|refseq:NP_001129603.1|dip:DIP-574N	refseq:NP_001012982.1|refseq:NP_001012983.1|refseq:NP_002765.1|refseq:NP_001306877.1|refseq:NP_001306878.1|ensembl:ENSG00000167755(gene)|ensembl:ENST00000310157(transcript)|ensembl:ENST00000376851(transcript)|ensembl:ENST00000594641(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007417"(central nervous system development)|go:"GO:0009611"(response to wounding)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030141"(secretory granule)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0042552"(myelination)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|rcsb pdb:1GVL|rcsb pdb:1L2E|rcsb pdb:1LO6|rcsb pdb:3VFE|rcsb pdb:4D8N|rcsb pdb:5NX1|rcsb pdb:5NX3|rcsb pdb:6QFF|rcsb pdb:6QFG|rcsb pdb:6QH9|rcsb pdb:6QHA|rcsb pdb:6QHB|rcsb pdb:6QHC|rcsb pdb:6SKB|rcsb pdb:6SKC|rcsb pdb:6SKD|rcsb pdb:6QFH	-	-	-	figure legend:Fig 5|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/09/01	2014/10/16	rogid:HatR8w8+mNjtjr7s5+bAwaStpmk9606	rogid:9KODhmrrHVMPBNTflnoTrvY9iOY9606	intact-crc:C414B4A9DE9B7359|rigid:Ys6MwUhYgxCngQ4TLNGNe2QJDyc	false	sufficient binding region:667-676|binding-associated region:670-671	sufficient binding region:17-244	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92876	uniprotkb:P47710	intact:EBI-2432309|uniprotkb:A8MW09|uniprotkb:Q6H301|uniprotkb:A6NJA1|ensembl:ENSP00000309148|ensembl:ENSP00000366047|ensembl:ENSP00000470482	intact:EBI-2433045|uniprotkb:A1A511|uniprotkb:A1A510|uniprotkb:E9PB60|uniprotkb:Q4PNR5|ensembl:ENSP00000246891	psi-mi:klk6_human(display_long)|uniprotkb:PRSS9(gene name synonym)|uniprotkb:KLK6(gene name)|psi-mi:KLK6(display_short)|uniprotkb:PRSS18(gene name synonym)|uniprotkb:Protease M(gene name synonym)|uniprotkb:Neurosin(gene name synonym)|uniprotkb:Zyme(gene name synonym)|uniprotkb:SP59(gene name synonym)|uniprotkb:Serine protease 9(gene name synonym)|uniprotkb:Serine protease 18(gene name synonym)	psi-mi:casa1_human(display_long)|uniprotkb:CSN1S1(gene name)|psi-mi:CSN1S1(display_short)|uniprotkb:CASA(gene name synonym)|uniprotkb:CSN1(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Magklara et al. (2003)	pubmed:12878203|imex:IM-20359	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2432355|imex:IM-20359-2	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001012982.1|refseq:NP_001012983.1|refseq:NP_002765.1|refseq:NP_001306877.1|refseq:NP_001306878.1|ensembl:ENSG00000167755(gene)|ensembl:ENST00000310157(transcript)|ensembl:ENST00000376851(transcript)|ensembl:ENST00000594641(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007417"(central nervous system development)|go:"GO:0009611"(response to wounding)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030141"(secretory granule)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0042552"(myelination)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|rcsb pdb:1GVL|rcsb pdb:1L2E|rcsb pdb:1LO6|rcsb pdb:3VFE|rcsb pdb:4D8N|rcsb pdb:5NX1|rcsb pdb:5NX3|rcsb pdb:6QFF|rcsb pdb:6QFG|rcsb pdb:6QH9|rcsb pdb:6QHA|rcsb pdb:6QHB|rcsb pdb:6QHC|rcsb pdb:6SKB|rcsb pdb:6SKC|rcsb pdb:6SKD|rcsb pdb:6QFH	refseq:NP_001020275.1|refseq:NP_001881.1|refseq:XP_006714152.1|refseq:XP_006714153.1|ensembl:ENSG00000126545(gene)|ensembl:ENST00000246891(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:1903494"(response to dehydroepiandrosterone)|go:"GO:1903496"(response to 11-deoxycorticosterone)|interpro:IPR026999|interpro:IPR031305|reactome:R-HSA-5223345	-	-	-	figure legend:Fig 3A|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/09/01	2014/10/16	rogid:9KODhmrrHVMPBNTflnoTrvY9iOY9606	rogid:S1hoNny7beaI4vqe9arajYsonPc9606	intact-crc:B07D53EB68C6DA0D|rigid:icKqLkYcZYF7Rnl/AGm26JQBGTU	false	sufficient binding region:17-244	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92876	uniprotkb:P02675	intact:EBI-2432309|uniprotkb:A8MW09|uniprotkb:Q6H301|uniprotkb:A6NJA1|ensembl:ENSP00000309148|ensembl:ENSP00000366047|ensembl:ENSP00000470482	intact:EBI-1034445|uniprotkb:A0JLR9|uniprotkb:Q32Q65|uniprotkb:Q3KPF2|uniprotkb:B2R7G3|ensembl:ENSP00000306099	psi-mi:klk6_human(display_long)|uniprotkb:PRSS9(gene name synonym)|uniprotkb:KLK6(gene name)|psi-mi:KLK6(display_short)|uniprotkb:PRSS18(gene name synonym)|uniprotkb:Protease M(gene name synonym)|uniprotkb:Neurosin(gene name synonym)|uniprotkb:Zyme(gene name synonym)|uniprotkb:SP59(gene name synonym)|uniprotkb:Serine protease 9(gene name synonym)|uniprotkb:Serine protease 18(gene name synonym)	psi-mi:fibb_human(display_long)|uniprotkb:FGB(gene name)|psi-mi:FGB(display_short)	psi-mi:"MI:0435"(protease assay)	Magklara et al. (2003)	pubmed:12878203|imex:IM-20359	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2432370|imex:IM-20359-3	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001012982.1|refseq:NP_001012983.1|refseq:NP_002765.1|refseq:NP_001306877.1|refseq:NP_001306878.1|ensembl:ENSG00000167755(gene)|ensembl:ENST00000310157(transcript)|ensembl:ENST00000376851(transcript)|ensembl:ENST00000594641(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007417"(central nervous system development)|go:"GO:0009611"(response to wounding)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030141"(secretory granule)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0042552"(myelination)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|rcsb pdb:1GVL|rcsb pdb:1L2E|rcsb pdb:1LO6|rcsb pdb:3VFE|rcsb pdb:4D8N|rcsb pdb:5NX1|rcsb pdb:5NX3|rcsb pdb:6QFF|rcsb pdb:6QFG|rcsb pdb:6QH9|rcsb pdb:6QHA|rcsb pdb:6QHB|rcsb pdb:6QHC|rcsb pdb:6SKB|rcsb pdb:6SKC|rcsb pdb:6SKD|rcsb pdb:6QFH	refseq:NP_001171670.1|refseq:NP_005132.2|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031639"(plasminogen activation)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034622"|go:"GO:0042730"(fibrinolysis)|go:"GO:0043152"(induction of bacterial agglutination)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051087"(chaperone binding)|go:"GO:0051258"(protein polymerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0072562"(blood microparticle)|go:"GO:0090277"(positive regulation of peptide hormone secretion)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1903561"(extracellular vesicle)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR012290(Fibrinogen, alpha/beta/gamma chain, coiled coil)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR036056|interpro:IPR037580|mint:P02675|rcsb pdb:1FZA|rcsb pdb:1FZB|rcsb pdb:1FZC|rcsb pdb:1FZE|rcsb pdb:1FZF|rcsb pdb:1FZG|rcsb pdb:1LT9|rcsb pdb:1LTJ|rcsb pdb:1N86|rcsb pdb:1N8E|rcsb pdb:1RE3|rcsb pdb:1RE4|rcsb pdb:1RF0|rcsb pdb:1RF1|rcsb pdb:2A45|rcsb pdb:2FFD|rcsb pdb:2H43|rcsb pdb:2HLO|rcsb pdb:2HOD|rcsb pdb:2HPC|rcsb pdb:2OYH|rcsb pdb:2OYI|rcsb pdb:2Q9I|rcsb pdb:2XNX|rcsb pdb:2XNY|rcsb pdb:2Z4E|rcsb pdb:3BVH|rcsb pdb:3E1I|rcsb pdb:3GHG|rcsb pdb:3H32|rcsb pdb:3HUS|rcsb pdb:6ATZ|rcsb pdb:6BIJ|rcsb pdb:6BIL|rcsb pdb:6V0Y|rcsb pdb:6V13|rcsb pdb:6V15|rcsb pdb:6V18|rcsb pdb:6V19|rcsb pdb:6V1A|reactome:R-HSA-114608|reactome:R-HSA-1236974|reactome:R-HSA-140875|reactome:R-HSA-166058|reactome:R-HSA-216083|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5674135|reactome:R-HSA-5686938|reactome:R-HSA-6802946|ensembl:ENSG00000171564(gene)|ensembl:ENST00000302068(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-6802952|reactome:R-HSA-6802948|dip:DIP-385N	-	-	-	figure legend:Fig 3B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/09/01	2014/10/16	rogid:9KODhmrrHVMPBNTflnoTrvY9iOY9606	rogid:cbcOBnZB/W/Y7eE/IxM2HfZHpK49606	intact-crc:AD2464082903BA59|rigid:4XZgdJKpr8XW+RINDdKDUNRSdC4	false	sufficient binding region:17-244	tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92876	uniprotkb:P02453	intact:EBI-2432309|uniprotkb:A8MW09|uniprotkb:Q6H301|uniprotkb:A6NJA1|ensembl:ENSP00000309148|ensembl:ENSP00000366047|ensembl:ENSP00000470482	intact:EBI-2432384|uniprotkb:Q3MHM2|ensembl:ENSBTAP00000017420	psi-mi:klk6_human(display_long)|uniprotkb:PRSS9(gene name synonym)|uniprotkb:KLK6(gene name)|psi-mi:KLK6(display_short)|uniprotkb:PRSS18(gene name synonym)|uniprotkb:Protease M(gene name synonym)|uniprotkb:Neurosin(gene name synonym)|uniprotkb:Zyme(gene name synonym)|uniprotkb:SP59(gene name synonym)|uniprotkb:Serine protease 9(gene name synonym)|uniprotkb:Serine protease 18(gene name synonym)	psi-mi:co1a1_bovin(display_long)|uniprotkb:COL1A1(gene name)|psi-mi:COL1A1(display_short)|uniprotkb:Alpha-1 type I collagen(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Magklara et al. (2003)	pubmed:12878203|imex:IM-20359	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2432380|imex:IM-20359-4	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001012982.1|refseq:NP_001012983.1|refseq:NP_002765.1|refseq:NP_001306877.1|refseq:NP_001306878.1|ensembl:ENSG00000167755(gene)|ensembl:ENST00000310157(transcript)|ensembl:ENST00000376851(transcript)|ensembl:ENST00000594641(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007417"(central nervous system development)|go:"GO:0009611"(response to wounding)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030141"(secretory granule)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0042552"(myelination)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|rcsb pdb:1GVL|rcsb pdb:1L2E|rcsb pdb:1LO6|rcsb pdb:3VFE|rcsb pdb:4D8N|rcsb pdb:5NX1|rcsb pdb:5NX3|rcsb pdb:6QFF|rcsb pdb:6QFG|rcsb pdb:6QH9|rcsb pdb:6QHA|rcsb pdb:6QHB|rcsb pdb:6QHC|rcsb pdb:6SKB|rcsb pdb:6SKC|rcsb pdb:6SKD|rcsb pdb:6QFH	refseq:NP_001029211.1|ensembl:ENSBTAG00000013103(gene)|ensembl:ENSBTAT00000017420(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001957"(intramembranous ossification)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002020"(protease binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005584"(collagen type I trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0015031"(protein transport)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032964"(collagen biosynthetic process)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034505"(tooth mineralization)|go:"GO:0038063"(collagen-activated tyrosine kinase receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043588"(skin development)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048407"(platelet-derived growth factor binding)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060346"(bone trabecula formation)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR000885(Fibrillar collagen, C-terminal)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR008160(Collagen triple helix repeat)|reactome:R-BTA-114604|reactome:R-BTA-1650814	-	-	-	figure legend:Fig 4A|comment:"Collagen type I is a better substrate for Klk6, being rapidly degraded by low enzyme concentrations (1uM). Collagen type IV degradation by Klk6 required longer incubation times and higher Klk6 concentrations (10uM)."|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/09/01	2014/10/16	rogid:9KODhmrrHVMPBNTflnoTrvY9iOY9606	rogid:RFO0aYMTX2Dq0gmxqCk3oQFLWkQ9913	intact-crc:880BBD606334ACEB|rigid:Wo8KaYgQO/4FqBq9bdJyKFNYPHo	false	sufficient binding region:17-244	tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92876	uniprotkb:Q14031	intact:EBI-2432309|uniprotkb:A8MW09|uniprotkb:Q6H301|uniprotkb:A6NJA1|ensembl:ENSP00000309148|ensembl:ENSP00000366047|ensembl:ENSP00000470482	intact:EBI-2432407|uniprotkb:Q12823|uniprotkb:Q14053|uniprotkb:Q5JYH6|uniprotkb:Q9NQM5|uniprotkb:Q9NTX3|uniprotkb:Q9UJ76|uniprotkb:Q9UMG6|uniprotkb:Q9Y4L4|uniprotkb:Q5JYH8|ensembl:ENSP00000361290	psi-mi:klk6_human(display_long)|uniprotkb:PRSS9(gene name synonym)|uniprotkb:KLK6(gene name)|psi-mi:KLK6(display_short)|uniprotkb:PRSS18(gene name synonym)|uniprotkb:Protease M(gene name synonym)|uniprotkb:Neurosin(gene name synonym)|uniprotkb:Zyme(gene name synonym)|uniprotkb:SP59(gene name synonym)|uniprotkb:Serine protease 9(gene name synonym)|uniprotkb:Serine protease 18(gene name synonym)	psi-mi:co4a6_human(display_long)|uniprotkb:COL4A6(gene name)|psi-mi:COL4A6(display_short)	psi-mi:"MI:0435"(protease assay)	Magklara et al. (2003)	pubmed:12878203|imex:IM-20359	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2432402|imex:IM-20359-5	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001012982.1|refseq:NP_001012983.1|refseq:NP_002765.1|refseq:NP_001306877.1|refseq:NP_001306878.1|ensembl:ENSG00000167755(gene)|ensembl:ENST00000310157(transcript)|ensembl:ENST00000376851(transcript)|ensembl:ENST00000594641(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007417"(central nervous system development)|go:"GO:0009611"(response to wounding)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030141"(secretory granule)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0042552"(myelination)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|rcsb pdb:1GVL|rcsb pdb:1L2E|rcsb pdb:1LO6|rcsb pdb:3VFE|rcsb pdb:4D8N|rcsb pdb:5NX1|rcsb pdb:5NX3|rcsb pdb:6QFF|rcsb pdb:6QFG|rcsb pdb:6QH9|rcsb pdb:6QHA|rcsb pdb:6QHB|rcsb pdb:6QHC|rcsb pdb:6SKB|rcsb pdb:6SKC|rcsb pdb:6SKD|rcsb pdb:6QFH	refseq:NP_001838.2|refseq:NP_378667.1|refseq:NP_001274689.1|ensembl:ENSG00000197565(gene)|ensembl:ENST00000372216(transcript)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005587"(collagen type IV trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0007155"(cell adhesion)|go:"GO:0030020"(extracellular matrix structural constituent conferring tensile strength)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0038063"(collagen-activated tyrosine kinase receptor signaling pathway)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071230"(cellular response to amino acid stimulus)|interpro:IPR001442(Type 4 procollagen, C-terminal repeat)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR016187(C-type lectin fold)|interpro:IPR036954|mint:Q14031|reactome:R-HSA-1442490|reactome:R-HSA-1474244|reactome:R-HSA-1650814|reactome:R-HSA-2022090|reactome:R-HSA-216083|reactome:R-HSA-2214320|reactome:R-HSA-2243919|reactome:R-HSA-3000157|reactome:R-HSA-3000171|reactome:R-HSA-3000178|reactome:R-HSA-8948216	-	-	-	figure legend:Fig 4A|comment:"Collagen type I is a better substrate for Klk6, being rapidly degraded by low enzyme concentrations (1uM). Collagen type IV degradation by Klk6 required longer incubation times and higher Klk6 concentrations (10uM)."|comment:Collagen alpha chain composition is not specified in publication thus all 6 potential chains are included in the interaction curation.|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/09/01	2014/10/16	rogid:9KODhmrrHVMPBNTflnoTrvY9iOY9606	rogid:dA4HuPkG1ACAg6cW2ZOcSUSysCE9606	intact-crc:E960C1EE962C35F2|rigid:950MHEFdaEUqU9OYlptPipSM7dc	false	sufficient binding region:17-244	tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92876	uniprotkb:P02671	intact:EBI-2432309|uniprotkb:A8MW09|uniprotkb:Q6H301|uniprotkb:A6NJA1|ensembl:ENSP00000309148|ensembl:ENSP00000366047|ensembl:ENSP00000470482	intact:EBI-348571|ensembl:ENSP00000498441|uniprotkb:Q9BX62|uniprotkb:Q9UCH2|uniprotkb:A8K3E4|uniprotkb:Q4QQH7|uniprotkb:D3DP14|uniprotkb:D3DP15	psi-mi:klk6_human(display_long)|uniprotkb:PRSS9(gene name synonym)|uniprotkb:KLK6(gene name)|psi-mi:KLK6(display_short)|uniprotkb:PRSS18(gene name synonym)|uniprotkb:Protease M(gene name synonym)|uniprotkb:Neurosin(gene name synonym)|uniprotkb:Zyme(gene name synonym)|uniprotkb:SP59(gene name synonym)|uniprotkb:Serine protease 9(gene name synonym)|uniprotkb:Serine protease 18(gene name synonym)	psi-mi:fiba_human(display_long)|uniprotkb:FGA(gene name)|psi-mi:FGA(display_short)	psi-mi:"MI:0435"(protease assay)	Magklara et al. (2003)	pubmed:12878203|imex:IM-20359	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2432441|imex:IM-20359-6	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001012982.1|refseq:NP_001012983.1|refseq:NP_002765.1|refseq:NP_001306877.1|refseq:NP_001306878.1|ensembl:ENSG00000167755(gene)|ensembl:ENST00000310157(transcript)|ensembl:ENST00000376851(transcript)|ensembl:ENST00000594641(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007417"(central nervous system development)|go:"GO:0009611"(response to wounding)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030141"(secretory granule)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0042552"(myelination)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|rcsb pdb:1GVL|rcsb pdb:1L2E|rcsb pdb:1LO6|rcsb pdb:3VFE|rcsb pdb:4D8N|rcsb pdb:5NX1|rcsb pdb:5NX3|rcsb pdb:6QFF|rcsb pdb:6QFG|rcsb pdb:6QH9|rcsb pdb:6QHA|rcsb pdb:6QHB|rcsb pdb:6QHC|rcsb pdb:6SKB|rcsb pdb:6SKC|rcsb pdb:6SKD|rcsb pdb:6QFH	refseq:NP_000499.1|refseq:NP_068657.1|ensembl:ENSG00000171560(gene)|ensembl:ENST00000651975(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:1903561"(extracellular vesicle)|go:"GO:2000261"(negative regulation of blood coagulation, common pathway)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR012290(Fibrinogen, alpha/beta/gamma chain, coiled coil)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0072377"(blood coagulation, common pathway)|interpro:IPR021996|interpro:IPR036056|interpro:IPR037579|mint:P02671|rcsb pdb:1BBR|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0072562"(blood microparticle)|rcsb pdb:1DM4|rcsb pdb:1FPH|rcsb pdb:1FZA|rcsb pdb:1FZB|go:"GO:0090277"(positive regulation of peptide hormone secretion)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|rcsb pdb:1FZC|rcsb pdb:1FZD|go:"GO:0031639"(plasminogen activation)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034622"|go:"GO:0042730"(fibrinolysis)|go:"GO:0043152"(induction of bacterial agglutination)|go:"GO:0045087"(innate immune response)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051258"(protein polymerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:1FZF|rcsb pdb:1FZG|rcsb pdb:1LT9|rcsb pdb:1LTJ|rcsb pdb:1N86|rcsb pdb:1N8E|rcsb pdb:1RE3|rcsb pdb:1RE4|rcsb pdb:1RF0|rcsb pdb:1RF1|rcsb pdb:1YCP|rcsb pdb:2A45|rcsb pdb:2FFD|rcsb pdb:2H43|rcsb pdb:2HLO|rcsb pdb:2HOD|rcsb pdb:2HPC|rcsb pdb:2OYH|rcsb pdb:2OYI|rcsb pdb:2Q9I|rcsb pdb:2XNX|rcsb pdb:2XNY|rcsb pdb:2Z4E|rcsb pdb:3AT0|rcsb pdb:1FZE|rcsb pdb:3BVH|rcsb pdb:3E1I|rcsb pdb:3GHG|rcsb pdb:3H32|rcsb pdb:3HUS|rcsb pdb:4F27|rcsb pdb:5CFA|reactome:R-HSA-114608|reactome:R-HSA-1236974|reactome:R-HSA-5674135|reactome:R-HSA-140875|reactome:R-HSA-166058|reactome:R-HSA-216083|reactome:R-HSA-354192|reactome:R-HSA-5686938|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-381426|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-8957275|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-977225|dip:DIP-29643N	-	-	-	figure legend:Fig 3B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/09/01	2014/10/16	rogid:9KODhmrrHVMPBNTflnoTrvY9iOY9606	rogid:khlQGVpd+6qZLTrsT9KxlxgjMR09606	intact-crc:76F9FDADA9ADC53F|rigid:EfmFxDvPEyRQsQ6BmChsbvXlH7M	false	sufficient binding region:17-244	tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02465	uniprotkb:Q92876	intact:EBI-2432455|uniprotkb:A6QP13|uniprotkb:O62649|ensembl:ENSBTAP00000033771	intact:EBI-2432309|uniprotkb:A8MW09|uniprotkb:Q6H301|uniprotkb:A6NJA1|ensembl:ENSP00000309148|ensembl:ENSP00000366047|ensembl:ENSP00000470482	psi-mi:co1a2_bovin(display_long)|uniprotkb:COL1A2(gene name)|psi-mi:COL1A2(display_short)|uniprotkb:Alpha-2 type I collagen(gene name synonym)	psi-mi:klk6_human(display_long)|uniprotkb:PRSS9(gene name synonym)|uniprotkb:KLK6(gene name)|psi-mi:KLK6(display_short)|uniprotkb:PRSS18(gene name synonym)|uniprotkb:Protease M(gene name synonym)|uniprotkb:Neurosin(gene name synonym)|uniprotkb:Zyme(gene name synonym)|uniprotkb:SP59(gene name synonym)|uniprotkb:Serine protease 9(gene name synonym)|uniprotkb:Serine protease 18(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Magklara et al. (2003)	pubmed:12878203|imex:IM-20359	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2432451|imex:IM-20359-7	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_776945.1|ensembl:ENSBTAG00000013472(gene)|ensembl:ENSBTAT00000033863(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001568"(blood vessel development)|go:"GO:0002020"(protease binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005584"(collagen type I trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030282"(bone mineralization)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048407"(platelet-derived growth factor binding)|go:"GO:0070208"(protein heterotrimerization)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0085029"(extracellular matrix assembly)|interpro:IPR000885(Fibrillar collagen, C-terminal)|interpro:IPR008160(Collagen triple helix repeat)	refseq:NP_001012982.1|refseq:NP_001012983.1|refseq:NP_002765.1|refseq:NP_001306877.1|refseq:NP_001306878.1|ensembl:ENSG00000167755(gene)|ensembl:ENST00000310157(transcript)|ensembl:ENST00000376851(transcript)|ensembl:ENST00000594641(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007417"(central nervous system development)|go:"GO:0009611"(response to wounding)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030141"(secretory granule)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0042552"(myelination)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|rcsb pdb:1GVL|rcsb pdb:1L2E|rcsb pdb:1LO6|rcsb pdb:3VFE|rcsb pdb:4D8N|rcsb pdb:5NX1|rcsb pdb:5NX3|rcsb pdb:6QFF|rcsb pdb:6QFG|rcsb pdb:6QH9|rcsb pdb:6QHA|rcsb pdb:6QHB|rcsb pdb:6QHC|rcsb pdb:6SKB|rcsb pdb:6SKC|rcsb pdb:6SKD|rcsb pdb:6QFH	-	-	-	figure legend:Fig 4A|comment:"Collagen type I is a better substrate for Klk6, being rapidly degraded by low enzyme concentrations (1uM). Collagen type IV degradation by Klk6 required longer incubation times and higher Klk6 concentrations (10uM)."|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/09/01	2014/10/16	rogid:Ffl+sjurzfG0qlTogp5/WE52qNc9913	rogid:9KODhmrrHVMPBNTflnoTrvY9iOY9606	intact-crc:5678686373EA56A8|rigid:ObCOWBJr0TD2dpcwxvCtQI78Fp0	false	tag:?-?	sufficient binding region:17-244	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02462	uniprotkb:Q92876	intact:EBI-2432478|uniprotkb:B1AM70|uniprotkb:A7E2W4|uniprotkb:Q1P9S9|uniprotkb:Q5VWF6|uniprotkb:Q86X41|uniprotkb:Q8NF88|uniprotkb:Q9NYC5|uniprotkb:F5H5K0|ensembl:ENSP00000364979	intact:EBI-2432309|uniprotkb:A8MW09|uniprotkb:Q6H301|uniprotkb:A6NJA1|ensembl:ENSP00000309148|ensembl:ENSP00000366047|ensembl:ENSP00000470482	psi-mi:co4a1_human(display_long)|uniprotkb:COL4A1(gene name)|psi-mi:COL4A1(display_short)	psi-mi:klk6_human(display_long)|uniprotkb:PRSS9(gene name synonym)|uniprotkb:KLK6(gene name)|psi-mi:KLK6(display_short)|uniprotkb:PRSS18(gene name synonym)|uniprotkb:Protease M(gene name synonym)|uniprotkb:Neurosin(gene name synonym)|uniprotkb:Zyme(gene name synonym)|uniprotkb:SP59(gene name synonym)|uniprotkb:Serine protease 9(gene name synonym)|uniprotkb:Serine protease 18(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Magklara et al. (2003)	pubmed:12878203|imex:IM-20359	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2432473|imex:IM-20359-8	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001290039.1|refseq:NP_001836.3|ensembl:ENSG00000187498(gene)|ensembl:ENST00000375820(transcript)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005587"(collagen type IV trimer)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0007420"(brain development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0030020"(extracellular matrix structural constituent conferring tensile strength)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031012"(extracellular matrix)|go:"GO:0038063"(collagen-activated tyrosine kinase receptor signaling pathway)|go:"GO:0048407"(platelet-derived growth factor binding)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0061304"(retinal blood vessel morphogenesis)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071711"(basement membrane organization)|interpro:IPR001442(Type 4 procollagen, C-terminal repeat)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR016187(C-type lectin fold)|interpro:IPR036954|mint:P02462|rcsb pdb:1LI1|rcsb pdb:5NAX|rcsb pdb:5NAY|rcsb pdb:6MPX|reactome:R-HSA-1442490|reactome:R-HSA-1474244|reactome:R-HSA-1650814|reactome:R-HSA-186797|reactome:R-HSA-2022090|reactome:R-HSA-216083|reactome:R-HSA-2214320|reactome:R-HSA-2243919|reactome:R-HSA-3000157|reactome:R-HSA-3000171|reactome:R-HSA-3000178|reactome:R-HSA-3000480|reactome:R-HSA-419037|reactome:R-HSA-8948216	refseq:NP_001012982.1|refseq:NP_001012983.1|refseq:NP_002765.1|refseq:NP_001306877.1|refseq:NP_001306878.1|ensembl:ENSG00000167755(gene)|ensembl:ENST00000310157(transcript)|ensembl:ENST00000376851(transcript)|ensembl:ENST00000594641(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007417"(central nervous system development)|go:"GO:0009611"(response to wounding)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030141"(secretory granule)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0042552"(myelination)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|rcsb pdb:1GVL|rcsb pdb:1L2E|rcsb pdb:1LO6|rcsb pdb:3VFE|rcsb pdb:4D8N|rcsb pdb:5NX1|rcsb pdb:5NX3|rcsb pdb:6QFF|rcsb pdb:6QFG|rcsb pdb:6QH9|rcsb pdb:6QHA|rcsb pdb:6QHB|rcsb pdb:6QHC|rcsb pdb:6SKB|rcsb pdb:6SKC|rcsb pdb:6SKD|rcsb pdb:6QFH	-	-	-	figure legend:Fig 4A|comment:"Collagen type I is a better substrate for Klk6, being rapidly degraded by low enzyme concentrations (1uM). Collagen type IV degradation by Klk6 required longer incubation times and higher Klk6 concentrations (10uM)."|comment:Collagen alpha chain composition is not specified in publication thus all 6 potential chains are included in the interaction curation.|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/09/01	2018/06/01	rogid:/U3Xsl1lPZnPBfd1cRVDqtuvVb49606	rogid:9KODhmrrHVMPBNTflnoTrvY9iOY9606	intact-crc:36B78E43E6814A1B|rigid:+ZGB/PCpN3n/cPygoh4v04o/QOk	false	tag:?-?	sufficient binding region:17-244	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92876	uniprotkb:P08572	intact:EBI-2432309|uniprotkb:A8MW09|uniprotkb:Q6H301|uniprotkb:A6NJA1|ensembl:ENSP00000309148|ensembl:ENSP00000366047|ensembl:ENSP00000470482	intact:EBI-2432506|uniprotkb:Q14052|uniprotkb:Q548C3|uniprotkb:Q5VZA9|uniprotkb:Q66K23|ensembl:ENSP00000353654	psi-mi:klk6_human(display_long)|uniprotkb:PRSS9(gene name synonym)|uniprotkb:KLK6(gene name)|psi-mi:KLK6(display_short)|uniprotkb:PRSS18(gene name synonym)|uniprotkb:Protease M(gene name synonym)|uniprotkb:Neurosin(gene name synonym)|uniprotkb:Zyme(gene name synonym)|uniprotkb:SP59(gene name synonym)|uniprotkb:Serine protease 9(gene name synonym)|uniprotkb:Serine protease 18(gene name synonym)	psi-mi:co4a2_human(display_long)|uniprotkb:COL4A2(gene name)|psi-mi:COL4A2(display_short)	psi-mi:"MI:0435"(protease assay)	Magklara et al. (2003)	pubmed:12878203|imex:IM-20359	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2432524|imex:IM-20359-9	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001012982.1|refseq:NP_001012983.1|refseq:NP_002765.1|refseq:NP_001306877.1|refseq:NP_001306878.1|ensembl:ENSG00000167755(gene)|ensembl:ENST00000310157(transcript)|ensembl:ENST00000376851(transcript)|ensembl:ENST00000594641(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007417"(central nervous system development)|go:"GO:0009611"(response to wounding)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030141"(secretory granule)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0042552"(myelination)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|rcsb pdb:1GVL|rcsb pdb:1L2E|rcsb pdb:1LO6|rcsb pdb:3VFE|rcsb pdb:4D8N|rcsb pdb:5NX1|rcsb pdb:5NX3|rcsb pdb:6QFF|rcsb pdb:6QFG|rcsb pdb:6QH9|rcsb pdb:6QHA|rcsb pdb:6QHB|rcsb pdb:6QHC|rcsb pdb:6SKB|rcsb pdb:6SKC|rcsb pdb:6SKD|rcsb pdb:6QFH	refseq:NP_001837.2|ensembl:ENSG00000134871(gene)|ensembl:ENST00000360467(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005587"(collagen type IV trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0007568"(aging)|go:"GO:0014823"(response to activity)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030020"(extracellular matrix structural constituent conferring tensile strength)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0038063"(collagen-activated tyrosine kinase receptor signaling pathway)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|interpro:IPR001442(Type 4 procollagen, C-terminal repeat)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR016187(C-type lectin fold)|interpro:IPR036954|rcsb pdb:1LI1|rcsb pdb:5NAX|rcsb pdb:5NB2|rcsb pdb:6MPX|reactome:R-HSA-1442490|reactome:R-HSA-1474244|reactome:R-HSA-1650814|reactome:R-HSA-186797|reactome:R-HSA-2022090|reactome:R-HSA-216083|reactome:R-HSA-2214320|reactome:R-HSA-2243919|reactome:R-HSA-3000157|reactome:R-HSA-3000171|reactome:R-HSA-3000178|reactome:R-HSA-3000480|reactome:R-HSA-419037|reactome:R-HSA-8948216	-	-	-	figure legend:Fig 4A|comment:"Collagen type I is a better substrate for Klk6, being rapidly degraded by low enzyme concentrations (1uM). Collagen type IV degradation by Klk6 required longer incubation times and higher Klk6 concentrations (10uM)."|comment:Collagen alpha chain composition is not specified in publication thus all 6 potential chains are included in the interaction curation.|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/09/01	2014/10/16	rogid:9KODhmrrHVMPBNTflnoTrvY9iOY9606	rogid:2jSdn1hb9JtAPdSLo82KAbqdzr09606	intact-crc:B408B4EF456F8272|rigid:2+90d6tABtASBNtxgSzt8aNTQBc	false	sufficient binding region:17-244	tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92876	uniprotkb:Q01955	intact:EBI-2432309|uniprotkb:A8MW09|uniprotkb:Q6H301|uniprotkb:A6NJA1|ensembl:ENSP00000309148|ensembl:ENSP00000366047|ensembl:ENSP00000470482	intact:EBI-2432535|uniprotkb:Q53QQ1|uniprotkb:Q53R14|uniprotkb:Q53RW8|uniprotkb:Q9BQT2|uniprotkb:Q9NYC4|uniprotkb:Q9UDJ9|uniprotkb:Q9UDK9|uniprotkb:Q9UDL0|uniprotkb:Q9UDL1|ensembl:ENSP00000379823	psi-mi:klk6_human(display_long)|uniprotkb:PRSS9(gene name synonym)|uniprotkb:KLK6(gene name)|psi-mi:KLK6(display_short)|uniprotkb:PRSS18(gene name synonym)|uniprotkb:Protease M(gene name synonym)|uniprotkb:Neurosin(gene name synonym)|uniprotkb:Zyme(gene name synonym)|uniprotkb:SP59(gene name synonym)|uniprotkb:Serine protease 9(gene name synonym)|uniprotkb:Serine protease 18(gene name synonym)	psi-mi:co4a3_human(display_long)|uniprotkb:COL4A3(gene name)|psi-mi:COL4A3(display_short)|uniprotkb:Goodpasture antigen(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Magklara et al. (2003)	pubmed:12878203|imex:IM-20359	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2432565|imex:IM-20359-10	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001012982.1|refseq:NP_001012983.1|refseq:NP_002765.1|refseq:NP_001306877.1|refseq:NP_001306878.1|ensembl:ENSG00000167755(gene)|ensembl:ENST00000310157(transcript)|ensembl:ENST00000376851(transcript)|ensembl:ENST00000594641(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007417"(central nervous system development)|go:"GO:0009611"(response to wounding)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030141"(secretory granule)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0042552"(myelination)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|rcsb pdb:1GVL|rcsb pdb:1L2E|rcsb pdb:1LO6|rcsb pdb:3VFE|rcsb pdb:4D8N|rcsb pdb:5NX1|rcsb pdb:5NX3|rcsb pdb:6QFF|rcsb pdb:6QFG|rcsb pdb:6QH9|rcsb pdb:6QHA|rcsb pdb:6QHB|rcsb pdb:6QHC|rcsb pdb:6SKB|rcsb pdb:6SKC|rcsb pdb:6SKD|rcsb pdb:6QFH	refseq:NP_000082.2|ensembl:ENSG00000169031(gene)|ensembl:ENST00000396578(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005587"(collagen type IV trimer)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008015"(blood circulation)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009749"(response to glucose)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030020"(extracellular matrix structural constituent conferring tensile strength)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032836"(glomerular basement membrane development)|go:"GO:0038063"(collagen-activated tyrosine kinase receptor signaling pathway)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:1905563"(negative regulation of vascular endothelial cell proliferation)|interpro:IPR001442(Type 4 procollagen, C-terminal repeat)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR016187(C-type lectin fold)|interpro:IPR036954|rcsb pdb:5NB0|rcsb pdb:6WKU|reactome:R-HSA-1442490|reactome:R-HSA-1474244|reactome:R-HSA-1650814|reactome:R-HSA-186797|reactome:R-HSA-2022090|reactome:R-HSA-216083|reactome:R-HSA-2214320|reactome:R-HSA-2243919|reactome:R-HSA-3000157|reactome:R-HSA-3000171|reactome:R-HSA-3000178|reactome:R-HSA-419037|reactome:R-HSA-8948216	-	-	-	figure legend:Fig 4A|comment:"Collagen type I is a better substrate for Klk6, being rapidly degraded by low enzyme concentrations (1uM). Collagen type IV degradation by Klk6 required longer incubation times and higher Klk6 concentrations (10uM)."|comment:Collagen alpha chain composition is not specified in publication thus all 6 potential chains are included in the interaction curation.|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/09/01	2014/10/16	rogid:9KODhmrrHVMPBNTflnoTrvY9iOY9606	rogid:UOLXbLaseF0W2/N0DjX7LCceZEM9606	intact-crc:97527BDED651C59C|rigid:qCz7DWrCV/Tl7pBLq0rYFtvwA9M	false	sufficient binding region:17-244	tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53420	uniprotkb:Q92876	intact:EBI-2432581|uniprotkb:A8MTZ1|uniprotkb:Q53RW9|uniprotkb:Q53S42|uniprotkb:Q53WR1|ensembl:ENSP00000379866	intact:EBI-2432309|uniprotkb:A8MW09|uniprotkb:Q6H301|uniprotkb:A6NJA1|ensembl:ENSP00000309148|ensembl:ENSP00000366047|ensembl:ENSP00000470482	psi-mi:co4a4_human(display_long)|uniprotkb:COL4A4(gene name)|psi-mi:COL4A4(display_short)	psi-mi:klk6_human(display_long)|uniprotkb:PRSS9(gene name synonym)|uniprotkb:KLK6(gene name)|psi-mi:KLK6(display_short)|uniprotkb:PRSS18(gene name synonym)|uniprotkb:Protease M(gene name synonym)|uniprotkb:Neurosin(gene name synonym)|uniprotkb:Zyme(gene name synonym)|uniprotkb:SP59(gene name synonym)|uniprotkb:Serine protease 9(gene name synonym)|uniprotkb:Serine protease 18(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Magklara et al. (2003)	pubmed:12878203|imex:IM-20359	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2432576|imex:IM-20359-11	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000083.3|refseq:XP_005246338.1|reactome:R-HSA-2022090|reactome:R-HSA-216083|reactome:R-HSA-2214320|reactome:R-HSA-2243919|reactome:R-HSA-3000157|reactome:R-HSA-3000171|reactome:R-HSA-3000178|reactome:R-HSA-419037|reactome:R-HSA-8948216|ensembl:ENSG00000081052(gene)|ensembl:ENST00000396625(transcript)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005587"(collagen type IV trimer)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032836"(glomerular basement membrane development)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001442(Type 4 procollagen, C-terminal repeat)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR016187(C-type lectin fold)|interpro:IPR036954|mint:P53420|rcsb pdb:5NB1|rcsb pdb:6WKU|reactome:R-HSA-1442490|reactome:R-HSA-1474244|reactome:R-HSA-1650814|reactome:R-HSA-186797	refseq:NP_001012982.1|refseq:NP_001012983.1|refseq:NP_002765.1|refseq:NP_001306877.1|refseq:NP_001306878.1|ensembl:ENSG00000167755(gene)|ensembl:ENST00000310157(transcript)|ensembl:ENST00000376851(transcript)|ensembl:ENST00000594641(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007417"(central nervous system development)|go:"GO:0009611"(response to wounding)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030141"(secretory granule)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0042552"(myelination)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|rcsb pdb:1GVL|rcsb pdb:1L2E|rcsb pdb:1LO6|rcsb pdb:3VFE|rcsb pdb:4D8N|rcsb pdb:5NX1|rcsb pdb:5NX3|rcsb pdb:6QFF|rcsb pdb:6QFG|rcsb pdb:6QH9|rcsb pdb:6QHA|rcsb pdb:6QHB|rcsb pdb:6QHC|rcsb pdb:6SKB|rcsb pdb:6SKC|rcsb pdb:6SKD|rcsb pdb:6QFH	-	-	-	figure legend:Fig 4A|comment:"Collagen type I is a better substrate for Klk6, being rapidly degraded by low enzyme concentrations (1uM). Collagen type IV degradation by Klk6 required longer incubation times and higher Klk6 concentrations (10uM)."|comment:Collagen alpha chain composition is not specified in publication thus all 6 potential chains are included in the interaction curation.|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/09/01	2014/10/16	rogid:33OBK6m4LBya+l/OQQ1JYlvFx109606	rogid:9KODhmrrHVMPBNTflnoTrvY9iOY9606	intact-crc:C54BC722758AB00D|rigid:IdS8pjFBvAOC+yyFviJAIO0He/Y	false	tag:?-?	sufficient binding region:17-244	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92876	uniprotkb:P29400	intact:EBI-2432309|uniprotkb:A8MW09|uniprotkb:Q6H301|uniprotkb:A6NJA1|ensembl:ENSP00000309148|ensembl:ENSP00000366047|ensembl:ENSP00000470482	intact:EBI-726908|ensembl:ENSP00000354505|uniprotkb:Q16006|uniprotkb:Q16126|uniprotkb:Q6LD84|uniprotkb:Q7Z700|uniprotkb:Q9NUB7	psi-mi:klk6_human(display_long)|uniprotkb:PRSS9(gene name synonym)|uniprotkb:KLK6(gene name)|psi-mi:KLK6(display_short)|uniprotkb:PRSS18(gene name synonym)|uniprotkb:Protease M(gene name synonym)|uniprotkb:Neurosin(gene name synonym)|uniprotkb:Zyme(gene name synonym)|uniprotkb:SP59(gene name synonym)|uniprotkb:Serine protease 9(gene name synonym)|uniprotkb:Serine protease 18(gene name synonym)	psi-mi:co4a5_human(display_long)|uniprotkb:COL4A5(gene name)|psi-mi:COL4A5(display_short)	psi-mi:"MI:0435"(protease assay)	Magklara et al. (2003)	pubmed:12878203|imex:IM-20359	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2432605|imex:IM-20359-12	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001012982.1|refseq:NP_001012983.1|refseq:NP_002765.1|refseq:NP_001306877.1|refseq:NP_001306878.1|ensembl:ENSG00000167755(gene)|ensembl:ENST00000310157(transcript)|ensembl:ENST00000376851(transcript)|ensembl:ENST00000594641(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007417"(central nervous system development)|go:"GO:0009611"(response to wounding)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030141"(secretory granule)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0042552"(myelination)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|rcsb pdb:1GVL|rcsb pdb:1L2E|rcsb pdb:1LO6|rcsb pdb:3VFE|rcsb pdb:4D8N|rcsb pdb:5NX1|rcsb pdb:5NX3|rcsb pdb:6QFF|rcsb pdb:6QFG|rcsb pdb:6QH9|rcsb pdb:6QHA|rcsb pdb:6QHB|rcsb pdb:6QHC|rcsb pdb:6SKB|rcsb pdb:6SKC|rcsb pdb:6SKD|rcsb pdb:6QFH	ensembl:ENSG00000188153(gene)|ensembl:ENST00000361603(transcript)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005587"(collagen type IV trimer)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0030020"(extracellular matrix structural constituent conferring tensile strength)|go:"GO:0030198"(extracellular matrix organization)|refseq:NP_000486.1|refseq:NP_203699.1|go:"GO:0031012"(extracellular matrix)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0038063"(collagen-activated tyrosine kinase receptor signaling pathway)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001442(Type 4 procollagen, C-terminal repeat)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR016187(C-type lectin fold)|interpro:IPR036954|rcsb pdb:5NAZ|rcsb pdb:6WKU|reactome:R-HSA-1442490|reactome:R-HSA-1474244|reactome:R-HSA-1650814|reactome:R-HSA-186797|reactome:R-HSA-2022090|reactome:R-HSA-216083|reactome:R-HSA-2214320|reactome:R-HSA-2243919|reactome:R-HSA-3000157|reactome:R-HSA-3000171|reactome:R-HSA-3000178|reactome:R-HSA-419037|reactome:R-HSA-8948216|reactome:R-HSA-9010553	-	-	-	figure legend:Fig 4A|comment:"Collagen type I is a better substrate for Klk6, being rapidly degraded by low enzyme concentrations (1uM). Collagen type IV degradation by Klk6 required longer incubation times and higher Klk6 concentrations (10uM)."|comment:Collagen alpha chain composition is not specified in publication thus all 6 potential chains are included in the interaction curation.|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/09/01	2014/10/16	rogid:9KODhmrrHVMPBNTflnoTrvY9iOY9606	rogid:sjXtWy1A1CNCSE+ZqFLnoGdjTv09606	intact-crc:A20F139A1B130F5F|rigid:2aRdChDzGmIxOO0NEb2r/rsL5rA	false	sufficient binding region:17-244	tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92876	intact:EBI-2432631	intact:EBI-2432309|uniprotkb:A8MW09|uniprotkb:Q6H301|uniprotkb:A6NJA1|ensembl:ENSP00000309148|ensembl:ENSP00000366047|ensembl:ENSP00000470482	-	psi-mi:klk6_human(display_long)|uniprotkb:PRSS9(gene name synonym)|uniprotkb:KLK6(gene name)|psi-mi:KLK6(display_short)|uniprotkb:PRSS18(gene name synonym)|uniprotkb:Protease M(gene name synonym)|uniprotkb:Neurosin(gene name synonym)|uniprotkb:Zyme(gene name synonym)|uniprotkb:SP59(gene name synonym)|uniprotkb:Serine protease 9(gene name synonym)|uniprotkb:Serine protease 18(gene name synonym)	psi-mi:pheserargamc(display_short)|psi-mi:EBI-2432631(display_long)	psi-mi:"MI:0435"(protease assay)	Magklara et al. (2003)	pubmed:12878203|imex:IM-20359	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:-1(in vitro)|taxid:-1(In vitro)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2432625|imex:IM-20359-13	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0327"(peptide)	refseq:NP_001012982.1|refseq:NP_001012983.1|refseq:NP_002765.1|refseq:NP_001306877.1|refseq:NP_001306878.1|ensembl:ENSG00000167755(gene)|ensembl:ENST00000310157(transcript)|ensembl:ENST00000376851(transcript)|ensembl:ENST00000594641(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007417"(central nervous system development)|go:"GO:0009611"(response to wounding)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030141"(secretory granule)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0042552"(myelination)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|rcsb pdb:1GVL|rcsb pdb:1L2E|rcsb pdb:1LO6|rcsb pdb:3VFE|rcsb pdb:4D8N|rcsb pdb:5NX1|rcsb pdb:5NX3|rcsb pdb:6QFF|rcsb pdb:6QFG|rcsb pdb:6QH9|rcsb pdb:6QHA|rcsb pdb:6QHB|rcsb pdb:6QHC|rcsb pdb:6SKB|rcsb pdb:6SKC|rcsb pdb:6SKD|rcsb pdb:6QFH	-	go:"GO:0008233"(peptidase activity)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt	figure legend:Table 1|kinetics:"Km(mM)= 0.41 kcat(min-1) = 38.3 kcat/Km (mM-1 min-1) = 93.4"|comment:An additional substrate, Glu-Lys-Lys-AMC was not hydrolysed by Klk6. Klk6 was also tested with a chymotrypsin-specific substrate, Ala-Ala-Pro-Phe-AMC, however no hydrolysis was detected, suggesting that human Klk6 posesses no such activity.|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/09/01	2014/10/16	rogid:9KODhmrrHVMPBNTflnoTrvY9iOY9606	-	intact-crc:8EF01A98AF01A814	false	sufficient binding region:17-244	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-2432644	uniprotkb:Q92876	-	intact:EBI-2432309|uniprotkb:A8MW09|uniprotkb:Q6H301|uniprotkb:A6NJA1|ensembl:ENSP00000309148|ensembl:ENSP00000366047|ensembl:ENSP00000470482	psi-mi:glyglyargamc(display_short)|psi-mi:EBI-2432644(display_long)	psi-mi:klk6_human(display_long)|uniprotkb:PRSS9(gene name synonym)|uniprotkb:KLK6(gene name)|psi-mi:KLK6(display_short)|uniprotkb:PRSS18(gene name synonym)|uniprotkb:Protease M(gene name synonym)|uniprotkb:Neurosin(gene name synonym)|uniprotkb:Zyme(gene name synonym)|uniprotkb:SP59(gene name synonym)|uniprotkb:Serine protease 9(gene name synonym)|uniprotkb:Serine protease 18(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Magklara et al. (2003)	pubmed:12878203|imex:IM-20359	taxid:-1(in vitro)|taxid:-1(In vitro)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2432638|imex:IM-20359-14	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001012982.1|refseq:NP_001012983.1|refseq:NP_002765.1|refseq:NP_001306877.1|refseq:NP_001306878.1|ensembl:ENSG00000167755(gene)|ensembl:ENST00000310157(transcript)|ensembl:ENST00000376851(transcript)|ensembl:ENST00000594641(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007417"(central nervous system development)|go:"GO:0009611"(response to wounding)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030141"(secretory granule)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0042552"(myelination)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|rcsb pdb:1GVL|rcsb pdb:1L2E|rcsb pdb:1LO6|rcsb pdb:3VFE|rcsb pdb:4D8N|rcsb pdb:5NX1|rcsb pdb:5NX3|rcsb pdb:6QFF|rcsb pdb:6QFG|rcsb pdb:6QH9|rcsb pdb:6QHA|rcsb pdb:6QHB|rcsb pdb:6QHC|rcsb pdb:6SKB|rcsb pdb:6SKC|rcsb pdb:6SKD|rcsb pdb:6QFH	go:"GO:0008233"(peptidase activity)	no-uniprot-update:An amino acid sequence which is not represented in UniProt	-	figure legend:Table 1|kinetics:"Km(mM)= 0.455,  kcat(min-1) = 6.5,  kcat/Km (mM-1 min-1) = 14.3,"|comment:An additional substrate, Glu-Lys-Lys-AMC was not hydrolysed by Klk6. Klk6 was also tested with a chymotrypsin-specific substrate, Ala-Ala-Pro-Phe-AMC, however no hydrolysis was detected, suggesting that human Klk6 posesses no such activity.|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/09/01	2014/10/16	-	rogid:9KODhmrrHVMPBNTflnoTrvY9iOY9606	intact-crc:CC7C411CA8BD4B23	false	-	sufficient binding region:17-244	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-2432651	uniprotkb:Q92876	-	intact:EBI-2432309|uniprotkb:A8MW09|uniprotkb:Q6H301|uniprotkb:A6NJA1|ensembl:ENSP00000309148|ensembl:ENSP00000366047|ensembl:ENSP00000470482	psi-mi:aspproargamc(display_short)|psi-mi:EBI-2432651(display_long)	psi-mi:klk6_human(display_long)|uniprotkb:PRSS9(gene name synonym)|uniprotkb:KLK6(gene name)|psi-mi:KLK6(display_short)|uniprotkb:PRSS18(gene name synonym)|uniprotkb:Protease M(gene name synonym)|uniprotkb:Neurosin(gene name synonym)|uniprotkb:Zyme(gene name synonym)|uniprotkb:SP59(gene name synonym)|uniprotkb:Serine protease 9(gene name synonym)|uniprotkb:Serine protease 18(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Magklara et al. (2003)	pubmed:12878203|imex:IM-20359	taxid:-1(in vitro)|taxid:-1(In vitro)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2432654|imex:IM-20359-15	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001012982.1|refseq:NP_001012983.1|refseq:NP_002765.1|refseq:NP_001306877.1|refseq:NP_001306878.1|ensembl:ENSG00000167755(gene)|ensembl:ENST00000310157(transcript)|ensembl:ENST00000376851(transcript)|ensembl:ENST00000594641(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007417"(central nervous system development)|go:"GO:0009611"(response to wounding)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030141"(secretory granule)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0042552"(myelination)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|rcsb pdb:1GVL|rcsb pdb:1L2E|rcsb pdb:1LO6|rcsb pdb:3VFE|rcsb pdb:4D8N|rcsb pdb:5NX1|rcsb pdb:5NX3|rcsb pdb:6QFF|rcsb pdb:6QFG|rcsb pdb:6QH9|rcsb pdb:6QHA|rcsb pdb:6QHB|rcsb pdb:6QHC|rcsb pdb:6SKB|rcsb pdb:6SKC|rcsb pdb:6SKD|rcsb pdb:6QFH	go:"GO:0008233"(peptidase activity)	no-uniprot-update:An amino acid sequence which is not represented in UniProt	-	figure legend:Table 1|kinetics:"Km(mM)= 0.335,  kcat(min-1) = 11.7,  kcat/Km (mM-1 min-1) = 34.9,"|comment:An additional substrate, Glu-Lys-Lys-AMC was not hydrolysed by Klk6. Klk6 was also tested with a chymotrypsin-specific substrate, Ala-Ala-Pro-Phe-AMC, however no hydrolysis was detected, suggesting that human Klk6 posesses no such activity.|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/09/01	2014/10/16	-	rogid:9KODhmrrHVMPBNTflnoTrvY9iOY9606	intact-crc:FDD7EC2A126BA2B0	false	-	sufficient binding region:17-244	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-2432664	uniprotkb:Q92876	-	intact:EBI-2432309|uniprotkb:A8MW09|uniprotkb:Q6H301|uniprotkb:A6NJA1|ensembl:ENSP00000309148|ensembl:ENSP00000366047|ensembl:ENSP00000470482	psi-mi:glnglyargamc(display_short)|psi-mi:EBI-2432664(display_long)	psi-mi:klk6_human(display_long)|uniprotkb:PRSS9(gene name synonym)|uniprotkb:KLK6(gene name)|psi-mi:KLK6(display_short)|uniprotkb:PRSS18(gene name synonym)|uniprotkb:Protease M(gene name synonym)|uniprotkb:Neurosin(gene name synonym)|uniprotkb:Zyme(gene name synonym)|uniprotkb:SP59(gene name synonym)|uniprotkb:Serine protease 9(gene name synonym)|uniprotkb:Serine protease 18(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Magklara et al. (2003)	pubmed:12878203|imex:IM-20359	taxid:-1(in vitro)|taxid:-1(In vitro)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2432667|imex:IM-20359-16	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001012982.1|refseq:NP_001012983.1|refseq:NP_002765.1|refseq:NP_001306877.1|refseq:NP_001306878.1|ensembl:ENSG00000167755(gene)|ensembl:ENST00000310157(transcript)|ensembl:ENST00000376851(transcript)|ensembl:ENST00000594641(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007417"(central nervous system development)|go:"GO:0009611"(response to wounding)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030141"(secretory granule)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0042552"(myelination)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|rcsb pdb:1GVL|rcsb pdb:1L2E|rcsb pdb:1LO6|rcsb pdb:3VFE|rcsb pdb:4D8N|rcsb pdb:5NX1|rcsb pdb:5NX3|rcsb pdb:6QFF|rcsb pdb:6QFG|rcsb pdb:6QH9|rcsb pdb:6QHA|rcsb pdb:6QHB|rcsb pdb:6QHC|rcsb pdb:6SKB|rcsb pdb:6SKC|rcsb pdb:6SKD|rcsb pdb:6QFH	go:"GO:0008233"(peptidase activity)	no-uniprot-update:An amino acid sequence which is not represented in UniProt	-	figure legend:Table 1|kinetics:"Km(mM)= 0.758,  kcat(min-1) = 6.25,  kcat/Km (mM-1 min-1) = 8.2,"|comment:An additional substrate, Glu-Lys-Lys-AMC was not hydrolysed by Klk6. Klk6 was also tested with a chymotrypsin-specific substrate, Ala-Ala-Pro-Phe-AMC, however no hydrolysis was detected, suggesting that human Klk6 posesses no such activity.|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/09/01	2014/10/16	-	rogid:9KODhmrrHVMPBNTflnoTrvY9iOY9606	intact-crc:9834430D1734D3A5	false	-	sufficient binding region:17-244	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92876	intact:EBI-2432677	intact:EBI-2432309|uniprotkb:A8MW09|uniprotkb:Q6H301|uniprotkb:A6NJA1|ensembl:ENSP00000309148|ensembl:ENSP00000366047|ensembl:ENSP00000470482	-	psi-mi:klk6_human(display_long)|uniprotkb:PRSS9(gene name synonym)|uniprotkb:KLK6(gene name)|psi-mi:KLK6(display_short)|uniprotkb:PRSS18(gene name synonym)|uniprotkb:Protease M(gene name synonym)|uniprotkb:Neurosin(gene name synonym)|uniprotkb:Zyme(gene name synonym)|uniprotkb:SP59(gene name synonym)|uniprotkb:Serine protease 9(gene name synonym)|uniprotkb:Serine protease 18(gene name synonym)	psi-mi:propheargamc(display_short)|psi-mi:EBI-2432677(display_long)	psi-mi:"MI:0435"(protease assay)	Magklara et al. (2003)	pubmed:12878203|imex:IM-20359	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:-1(in vitro)|taxid:-1(In vitro)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2432680|imex:IM-20359-17	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0327"(peptide)	refseq:NP_001012982.1|refseq:NP_001012983.1|refseq:NP_002765.1|refseq:NP_001306877.1|refseq:NP_001306878.1|ensembl:ENSG00000167755(gene)|ensembl:ENST00000310157(transcript)|ensembl:ENST00000376851(transcript)|ensembl:ENST00000594641(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007417"(central nervous system development)|go:"GO:0009611"(response to wounding)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030141"(secretory granule)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0042552"(myelination)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|rcsb pdb:1GVL|rcsb pdb:1L2E|rcsb pdb:1LO6|rcsb pdb:3VFE|rcsb pdb:4D8N|rcsb pdb:5NX1|rcsb pdb:5NX3|rcsb pdb:6QFF|rcsb pdb:6QFG|rcsb pdb:6QH9|rcsb pdb:6QHA|rcsb pdb:6QHB|rcsb pdb:6QHC|rcsb pdb:6SKB|rcsb pdb:6SKC|rcsb pdb:6SKD|rcsb pdb:6QFH	-	go:"GO:0008233"(peptidase activity)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt	figure legend:Table 1|kinetics:"Km(mM)= 0.625,  kcat(min-1) = 4.6,  kcat/Km (mM-1 min-1) = 7.4,"|comment:An additional substrate, Glu-Lys-Lys-AMC was not hydrolysed by Klk6. Klk6 was also tested with a chymotrypsin-specific substrate, Ala-Ala-Pro-Phe-AMC, however no hydrolysis was detected, suggesting that human Klk6 posesses no such activity.|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/09/01	2014/10/16	rogid:9KODhmrrHVMPBNTflnoTrvY9iOY9606	-	intact-crc:3D0EDA94EB890FC4	false	sufficient binding region:17-244	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92876	intact:EBI-2432690	intact:EBI-2432309|uniprotkb:A8MW09|uniprotkb:Q6H301|uniprotkb:A6NJA1|ensembl:ENSP00000309148|ensembl:ENSP00000366047|ensembl:ENSP00000470482	-	psi-mi:klk6_human(display_long)|uniprotkb:PRSS9(gene name synonym)|uniprotkb:KLK6(gene name)|psi-mi:KLK6(display_short)|uniprotkb:PRSS18(gene name synonym)|uniprotkb:Protease M(gene name synonym)|uniprotkb:Neurosin(gene name synonym)|uniprotkb:Zyme(gene name synonym)|uniprotkb:SP59(gene name synonym)|uniprotkb:Serine protease 9(gene name synonym)|uniprotkb:Serine protease 18(gene name synonym)	psi-mi:valproargamc(display_short)|psi-mi:EBI-2432690(display_long)	psi-mi:"MI:0435"(protease assay)	Magklara et al. (2003)	pubmed:12878203|imex:IM-20359	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:-1(in vitro)|taxid:-1(In vitro)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2432693|imex:IM-20359-18	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0327"(peptide)	refseq:NP_001012982.1|refseq:NP_001012983.1|refseq:NP_002765.1|refseq:NP_001306877.1|refseq:NP_001306878.1|ensembl:ENSG00000167755(gene)|ensembl:ENST00000310157(transcript)|ensembl:ENST00000376851(transcript)|ensembl:ENST00000594641(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007417"(central nervous system development)|go:"GO:0009611"(response to wounding)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030141"(secretory granule)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0042552"(myelination)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|rcsb pdb:1GVL|rcsb pdb:1L2E|rcsb pdb:1LO6|rcsb pdb:3VFE|rcsb pdb:4D8N|rcsb pdb:5NX1|rcsb pdb:5NX3|rcsb pdb:6QFF|rcsb pdb:6QFG|rcsb pdb:6QH9|rcsb pdb:6QHA|rcsb pdb:6QHB|rcsb pdb:6QHC|rcsb pdb:6SKB|rcsb pdb:6SKC|rcsb pdb:6SKD|rcsb pdb:6QFH	-	go:"GO:0008233"(peptidase activity)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt	figure legend:Table 1|kinetics:"Km(mM)= 0.271,  kcat(min-1) = 22.8,  kcat/Km (mM-1 min-1) = 84.4,"|comment:An additional substrate, Glu-Lys-Lys-AMC was not hydrolysed by Klk6. Klk6 was also tested with a chymotrypsin-specific substrate, Ala-Ala-Pro-Phe-AMC, however no hydrolysis was detected, suggesting that human Klk6 posesses no such activity.|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/09/01	2014/10/16	rogid:9KODhmrrHVMPBNTflnoTrvY9iOY9606	-	intact-crc:63E8610C10085FC0	false	sufficient binding region:17-244	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-2432709	uniprotkb:Q92876	-	intact:EBI-2432309|uniprotkb:A8MW09|uniprotkb:Q6H301|uniprotkb:A6NJA1|ensembl:ENSP00000309148|ensembl:ENSP00000366047|ensembl:ENSP00000470482	psi-mi:valleulysamc(display_short)|psi-mi:EBI-2432709(display_long)	psi-mi:klk6_human(display_long)|uniprotkb:PRSS9(gene name synonym)|uniprotkb:KLK6(gene name)|psi-mi:KLK6(display_short)|uniprotkb:PRSS18(gene name synonym)|uniprotkb:Protease M(gene name synonym)|uniprotkb:Neurosin(gene name synonym)|uniprotkb:Zyme(gene name synonym)|uniprotkb:SP59(gene name synonym)|uniprotkb:Serine protease 9(gene name synonym)|uniprotkb:Serine protease 18(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Magklara et al. (2003)	pubmed:12878203|imex:IM-20359	taxid:-1(in vitro)|taxid:-1(In vitro)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2432703|imex:IM-20359-19	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001012982.1|refseq:NP_001012983.1|refseq:NP_002765.1|refseq:NP_001306877.1|refseq:NP_001306878.1|ensembl:ENSG00000167755(gene)|ensembl:ENST00000310157(transcript)|ensembl:ENST00000376851(transcript)|ensembl:ENST00000594641(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007417"(central nervous system development)|go:"GO:0009611"(response to wounding)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030141"(secretory granule)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0042552"(myelination)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|rcsb pdb:1GVL|rcsb pdb:1L2E|rcsb pdb:1LO6|rcsb pdb:3VFE|rcsb pdb:4D8N|rcsb pdb:5NX1|rcsb pdb:5NX3|rcsb pdb:6QFF|rcsb pdb:6QFG|rcsb pdb:6QH9|rcsb pdb:6QHA|rcsb pdb:6QHB|rcsb pdb:6QHC|rcsb pdb:6SKB|rcsb pdb:6SKC|rcsb pdb:6SKD|rcsb pdb:6QFH	go:"GO:0008233"(peptidase activity)	no-uniprot-update:An amino acid sequence which is not represented in UniProt	-	figure legend:Table 1|kinetics:"Km(mM)= 1.72,  kcat(min-1) = 0.22,  kcat/Km (mM-1 min-1) = 0.13,"|comment:An additional substrate, Glu-Lys-Lys-AMC was not hydrolysed by Klk6. Klk6 was also tested with a chymotrypsin-specific substrate, Ala-Ala-Pro-Phe-AMC, however no hydrolysis was detected, suggesting that human Klk6 posesses no such activity.|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/09/01	2014/10/16	-	rogid:9KODhmrrHVMPBNTflnoTrvY9iOY9606	intact-crc:1648AC21B3FC526F	false	-	sufficient binding region:17-244	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92876	uniprotkb:Q92876	intact:EBI-2432309|uniprotkb:A8MW09|uniprotkb:Q6H301|uniprotkb:A6NJA1|ensembl:ENSP00000309148|ensembl:ENSP00000366047|ensembl:ENSP00000470482	intact:EBI-2432309|uniprotkb:A8MW09|uniprotkb:Q6H301|uniprotkb:A6NJA1|ensembl:ENSP00000309148|ensembl:ENSP00000366047|ensembl:ENSP00000470482	psi-mi:klk6_human(display_long)|uniprotkb:PRSS9(gene name synonym)|uniprotkb:KLK6(gene name)|psi-mi:KLK6(display_short)|uniprotkb:PRSS18(gene name synonym)|uniprotkb:Protease M(gene name synonym)|uniprotkb:Neurosin(gene name synonym)|uniprotkb:Zyme(gene name synonym)|uniprotkb:SP59(gene name synonym)|uniprotkb:Serine protease 9(gene name synonym)|uniprotkb:Serine protease 18(gene name synonym)	psi-mi:klk6_human(display_long)|uniprotkb:PRSS9(gene name synonym)|uniprotkb:KLK6(gene name)|psi-mi:KLK6(display_short)|uniprotkb:PRSS18(gene name synonym)|uniprotkb:Protease M(gene name synonym)|uniprotkb:Neurosin(gene name synonym)|uniprotkb:Zyme(gene name synonym)|uniprotkb:SP59(gene name synonym)|uniprotkb:Serine protease 9(gene name synonym)|uniprotkb:Serine protease 18(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Magklara et al. (2003)	pubmed:12878203|imex:IM-20359	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2432726|imex:IM-20359-20	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001012982.1|refseq:NP_001012983.1|refseq:NP_002765.1|refseq:NP_001306877.1|refseq:NP_001306878.1|ensembl:ENSG00000167755(gene)|ensembl:ENST00000310157(transcript)|ensembl:ENST00000376851(transcript)|ensembl:ENST00000594641(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007417"(central nervous system development)|go:"GO:0009611"(response to wounding)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030141"(secretory granule)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0042552"(myelination)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|rcsb pdb:1GVL|rcsb pdb:1L2E|rcsb pdb:1LO6|rcsb pdb:3VFE|rcsb pdb:4D8N|rcsb pdb:5NX1|rcsb pdb:5NX3|rcsb pdb:6QFF|rcsb pdb:6QFG|rcsb pdb:6QH9|rcsb pdb:6QHA|rcsb pdb:6QHB|rcsb pdb:6QHC|rcsb pdb:6SKB|rcsb pdb:6SKC|rcsb pdb:6SKD|rcsb pdb:6QFH	refseq:NP_001012982.1|refseq:NP_001012983.1|refseq:NP_002765.1|refseq:NP_001306877.1|refseq:NP_001306878.1|ensembl:ENSG00000167755(gene)|ensembl:ENST00000310157(transcript)|ensembl:ENST00000376851(transcript)|ensembl:ENST00000594641(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007417"(central nervous system development)|go:"GO:0009611"(response to wounding)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030141"(secretory granule)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0042552"(myelination)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|rcsb pdb:1GVL|rcsb pdb:1L2E|rcsb pdb:1LO6|rcsb pdb:3VFE|rcsb pdb:4D8N|rcsb pdb:5NX1|rcsb pdb:5NX3|rcsb pdb:6QFF|rcsb pdb:6QFG|rcsb pdb:6QH9|rcsb pdb:6QHA|rcsb pdb:6QHB|rcsb pdb:6QHC|rcsb pdb:6SKB|rcsb pdb:6SKC|rcsb pdb:6SKD|rcsb pdb:6QFH	go:"GO:0052547"(regulation of peptidase activity)	-	-	caution:Numbering for auto-cleavage site in figure legend and text differs from that used in the curation as it refers to a chemotrypsin based numbering of the amino acids, illustrated in reference 28.|figure legend:Fig 2|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/09/01	2014/10/16	rogid:9KODhmrrHVMPBNTflnoTrvY9iOY9606	rogid:9KODhmrrHVMPBNTflnoTrvY9iOY9606	intact-crc:C2255F977162C710|rigid:tiFtNa4KwZoJymYsXUXTxZa/z2Q	false	sufficient binding region:17-244|binding-associated region:80-81	sufficient binding region:17-244|binding-associated region:80-81	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)