#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P05150	uniprotkb:P00812	intact:EBI-12712|uniprotkb:D6VW96|ensemblfungi:YJL088W	intact:EBI-2856|uniprotkb:D6W3Q6|ensemblfungi:YPL111W	psi-mi:otc_yeast(display_long)|uniprotkb:ARG3(gene name)|psi-mi:ARG3(display_short)|uniprotkb:YJL088W(locus name)|uniprotkb:J0924(orf name)|uniprotkb:Ornithine transcarbamylase(gene name synonym)	psi-mi:argi_yeast(display_long)|uniprotkb:CAR1(gene name)|psi-mi:CAR1(display_short)|uniprotkb:LPH15W(orf name)|uniprotkb:YPL111W(locus name)	psi-mi:"MI:0726"(reverse two hybrid)	El et al. (2003)	pubmed:12679340|imex:IM-19025	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2355189|imex:IM-19025-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0019240"(citrulline biosynthetic process)|go:"GO:0005739"(mitochondrion)|go:"GO:0042450"(arginine biosynthetic process via ornithine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR002292(Ornithine carbamoyltransferase)|interpro:IPR006130(Aspartate/ornithine carbamoyltransferase)|go:"GO:0005829"(cytosol)|interpro:IPR006131(Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region)|interpro:IPR006132(Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding)|interpro:IPR036901|reactome:R-SCE-1268020|reactome:R-SCE-70635|go:"GO:0006526"(arginine biosynthetic process)|go:"GO:0016597"(amino acid binding)|ensemblfungi:YJL088W(gene)|ensemblfungi:YJL088W_mRNA(transcript)|go:"GO:0004585"(ornithine carbamoyltransferase activity)|refseq:NP_012447.1|sgd:S000003624|mint:P05150|dip:DIP-8093N	refseq:NP_015214.1|sgd:S000006032|dip:DIP-1224N|mint:P00812|ensemblfungi:YPL111W(gene)|ensemblfungi:YPL111W_mRNA(transcript)|go:"GO:0000050"(urea cycle)|go:"GO:0004053"(arginase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019547"(arginine catabolic process to ornithine)|go:"GO:0030145"(manganese ion binding)|go:"GO:0043332"(mating projection tip)|go:"GO:0090368"(regulation of ornithine metabolic process)|go:"GO:0090369"(ornithine carbamoyltransferase inhibitor activity)|interpro:IPR006035(Ureohydrolase)|interpro:IPR014033(Arginase, subgroup)|interpro:IPR020855|interpro:IPR023696|reactome:R-SCE-6798695|reactome:R-SCE-70635	-	crc64:6EBB6598FA93C59E	crc64:A5979DC9F1FDFF2E	figure legend:Fig. 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/06/19	2014/10/16	rogid:wDJ7Bk7AOiw+vOkhz++aG0UA0JM559292	rogid:XYywV9u8CT00GEzQ/csjxdv/K/8559292	intact-crc:AFF142B8D2131C2B|rigid:MAvIMIMX0eAIxvTiVleGaj5p6Mk	false	mutation decreasing interaction:182-182	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:17672"	chebi:"CHEBI:18257"	intact:EBI-2355734	intact:EBI-2355725	psi-mi:carbamoyl phosphate(display_short)|psi-mi:"CHEBI:17672"(display_long)	psi-mi:ornithine(display_short)|psi-mi:"CHEBI:18257"(display_long)	psi-mi:"MI:0415"(enzymatic study)	El et al. (2003)	pubmed:12679340|imex:IM-19025	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0414"(enzymatic reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2355736|imex:IM-19025-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0328"(small molecule)	-	-	go:"GO:0004585"(ornithine carbamoyltransferase activity)	-	-	figure legend:Fig. 2, Table 1|comment:Mutations of putative ornithine binding residues, Asp-182, Asn-184, Asn-185, Cys-289, and Glu-256 greatly reduced the affinity for ornithine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/19	2014/10/16	-	-	intact-crc:608AD497FE97DB1D	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:17672"	uniprotkb:P05150	intact:EBI-2355734	intact:EBI-12712|uniprotkb:D6VW96|ensemblfungi:YJL088W	psi-mi:carbamoyl phosphate(display_short)|psi-mi:"CHEBI:17672"(display_long)	psi-mi:otc_yeast(display_long)|uniprotkb:ARG3(gene name)|psi-mi:ARG3(display_short)|uniprotkb:YJL088W(locus name)|uniprotkb:J0924(orf name)|uniprotkb:Ornithine transcarbamylase(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	El et al. (2003)	pubmed:12679340|imex:IM-19025	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0414"(enzymatic reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2355736|imex:IM-19025-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0019240"(citrulline biosynthetic process)|go:"GO:0005739"(mitochondrion)|go:"GO:0042450"(arginine biosynthetic process via ornithine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR002292(Ornithine carbamoyltransferase)|interpro:IPR006130(Aspartate/ornithine carbamoyltransferase)|go:"GO:0005829"(cytosol)|interpro:IPR006131(Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region)|interpro:IPR006132(Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding)|interpro:IPR036901|reactome:R-SCE-1268020|reactome:R-SCE-70635|go:"GO:0006526"(arginine biosynthetic process)|go:"GO:0016597"(amino acid binding)|ensemblfungi:YJL088W(gene)|ensemblfungi:YJL088W_mRNA(transcript)|go:"GO:0004585"(ornithine carbamoyltransferase activity)|refseq:NP_012447.1|sgd:S000003624|mint:P05150|dip:DIP-8093N	go:"GO:0004585"(ornithine carbamoyltransferase activity)	-	crc64:6EBB6598FA93C59E	figure legend:Fig. 2, Table 1|comment:Mutations of putative ornithine binding residues, Asp-182, Asn-184, Asn-185, Cys-289, and Glu-256 greatly reduced the affinity for ornithine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/19	2014/10/16	-	rogid:wDJ7Bk7AOiw+vOkhz++aG0UA0JM559292	intact-crc:608AD497FE97DB1D	false	-	mutation decreasing interaction:290-290|mutation decreasing interaction:290-290|mutation disrupting interaction:181-181|mutation decreasing interaction:182-182|mutation decreasing interaction:184-184|mutation decreasing interaction:197-197,191-191,194-194|mutation decreasing interaction:256-256|mutation decreasing interaction:256-256|mutation decreasing interaction:263-263|mutation decreasing interaction:263-263|mutation decreasing interaction:265-265|mutation decreasing interaction:289-289|mutation decreasing interaction:68-68	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:17672"	uniprotkb:P00812	intact:EBI-2355734	intact:EBI-2856|uniprotkb:D6W3Q6|ensemblfungi:YPL111W	psi-mi:carbamoyl phosphate(display_short)|psi-mi:"CHEBI:17672"(display_long)	psi-mi:argi_yeast(display_long)|uniprotkb:CAR1(gene name)|psi-mi:CAR1(display_short)|uniprotkb:LPH15W(orf name)|uniprotkb:YPL111W(locus name)	psi-mi:"MI:0415"(enzymatic study)	El et al. (2003)	pubmed:12679340|imex:IM-19025	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0414"(enzymatic reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2355771|imex:IM-19025-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_015214.1|sgd:S000006032|dip:DIP-1224N|mint:P00812|ensemblfungi:YPL111W(gene)|ensemblfungi:YPL111W_mRNA(transcript)|go:"GO:0000050"(urea cycle)|go:"GO:0004053"(arginase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019547"(arginine catabolic process to ornithine)|go:"GO:0030145"(manganese ion binding)|go:"GO:0043332"(mating projection tip)|go:"GO:0090368"(regulation of ornithine metabolic process)|go:"GO:0090369"(ornithine carbamoyltransferase inhibitor activity)|interpro:IPR006035(Ureohydrolase)|interpro:IPR014033(Arginase, subgroup)|interpro:IPR020855|interpro:IPR023696|reactome:R-SCE-6798695|reactome:R-SCE-70635	go:"GO:0004585"(ornithine carbamoyltransferase activity)	-	crc64:A5979DC9F1FDFF2E	figure legend:Figs. 2 and 5, Table 1|comment:Mutations inhibit CAR1 binding to ARG3 and thus prevent the inhibition of ornithine carbamoyltransferase activity.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/19	2014/10/16	-	rogid:XYywV9u8CT00GEzQ/csjxdv/K/8559292	intact-crc:969D14A74F176EA6	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:18257"	uniprotkb:P00812	intact:EBI-2355725	intact:EBI-2856|uniprotkb:D6W3Q6|ensemblfungi:YPL111W	psi-mi:ornithine(display_short)|psi-mi:"CHEBI:18257"(display_long)	psi-mi:argi_yeast(display_long)|uniprotkb:CAR1(gene name)|psi-mi:CAR1(display_short)|uniprotkb:LPH15W(orf name)|uniprotkb:YPL111W(locus name)	psi-mi:"MI:0415"(enzymatic study)	El et al. (2003)	pubmed:12679340|imex:IM-19025	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0414"(enzymatic reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2355771|imex:IM-19025-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_015214.1|sgd:S000006032|dip:DIP-1224N|mint:P00812|ensemblfungi:YPL111W(gene)|ensemblfungi:YPL111W_mRNA(transcript)|go:"GO:0000050"(urea cycle)|go:"GO:0004053"(arginase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019547"(arginine catabolic process to ornithine)|go:"GO:0030145"(manganese ion binding)|go:"GO:0043332"(mating projection tip)|go:"GO:0090368"(regulation of ornithine metabolic process)|go:"GO:0090369"(ornithine carbamoyltransferase inhibitor activity)|interpro:IPR006035(Ureohydrolase)|interpro:IPR014033(Arginase, subgroup)|interpro:IPR020855|interpro:IPR023696|reactome:R-SCE-6798695|reactome:R-SCE-70635	go:"GO:0004585"(ornithine carbamoyltransferase activity)	-	crc64:A5979DC9F1FDFF2E	figure legend:Figs. 2 and 5, Table 1|comment:Mutations inhibit CAR1 binding to ARG3 and thus prevent the inhibition of ornithine carbamoyltransferase activity.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/19	2014/10/16	-	rogid:XYywV9u8CT00GEzQ/csjxdv/K/8559292	intact-crc:969D14A74F176EA6	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P00812	uniprotkb:P05150	intact:EBI-2856|uniprotkb:D6W3Q6|ensemblfungi:YPL111W	intact:EBI-12712|uniprotkb:D6VW96|ensemblfungi:YJL088W	psi-mi:argi_yeast(display_long)|uniprotkb:CAR1(gene name)|psi-mi:CAR1(display_short)|uniprotkb:LPH15W(orf name)|uniprotkb:YPL111W(locus name)	psi-mi:otc_yeast(display_long)|uniprotkb:ARG3(gene name)|psi-mi:ARG3(display_short)|uniprotkb:YJL088W(locus name)|uniprotkb:J0924(orf name)|uniprotkb:Ornithine transcarbamylase(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	El et al. (2003)	pubmed:12679340|imex:IM-19025	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0414"(enzymatic reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2355771|imex:IM-19025-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_015214.1|sgd:S000006032|dip:DIP-1224N|mint:P00812|ensemblfungi:YPL111W(gene)|ensemblfungi:YPL111W_mRNA(transcript)|go:"GO:0000050"(urea cycle)|go:"GO:0004053"(arginase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019547"(arginine catabolic process to ornithine)|go:"GO:0030145"(manganese ion binding)|go:"GO:0043332"(mating projection tip)|go:"GO:0090368"(regulation of ornithine metabolic process)|go:"GO:0090369"(ornithine carbamoyltransferase inhibitor activity)|interpro:IPR006035(Ureohydrolase)|interpro:IPR014033(Arginase, subgroup)|interpro:IPR020855|interpro:IPR023696|reactome:R-SCE-6798695|reactome:R-SCE-70635	go:"GO:0019240"(citrulline biosynthetic process)|go:"GO:0005739"(mitochondrion)|go:"GO:0042450"(arginine biosynthetic process via ornithine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR002292(Ornithine carbamoyltransferase)|interpro:IPR006130(Aspartate/ornithine carbamoyltransferase)|go:"GO:0005829"(cytosol)|interpro:IPR006131(Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region)|interpro:IPR006132(Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding)|interpro:IPR036901|reactome:R-SCE-1268020|reactome:R-SCE-70635|go:"GO:0006526"(arginine biosynthetic process)|go:"GO:0016597"(amino acid binding)|ensemblfungi:YJL088W(gene)|ensemblfungi:YJL088W_mRNA(transcript)|go:"GO:0004585"(ornithine carbamoyltransferase activity)|refseq:NP_012447.1|sgd:S000003624|mint:P05150|dip:DIP-8093N	go:"GO:0004585"(ornithine carbamoyltransferase activity)	crc64:A5979DC9F1FDFF2E	crc64:6EBB6598FA93C59E	figure legend:Figs. 2 and 5, Table 1|comment:Mutations inhibit CAR1 binding to ARG3 and thus prevent the inhibition of ornithine carbamoyltransferase activity.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/19	2014/10/16	rogid:XYywV9u8CT00GEzQ/csjxdv/K/8559292	rogid:wDJ7Bk7AOiw+vOkhz++aG0UA0JM559292	intact-crc:969D14A74F176EA6	false	-	mutation decreasing interaction:182-182|mutation decreasing interaction:184-184|mutation decreasing interaction:256-256|mutation decreasing interaction:256-256|mutation decreasing interaction:263-263|mutation decreasing interaction:263-263|mutation decreasing interaction:289-289|mutation decreasing interaction:185-185	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:17672"	uniprotkb:P00812	intact:EBI-2355734	intact:EBI-2856|uniprotkb:D6W3Q6|ensemblfungi:YPL111W	psi-mi:carbamoyl phosphate(display_short)|psi-mi:"CHEBI:17672"(display_long)	psi-mi:argi_yeast(display_long)|uniprotkb:CAR1(gene name)|psi-mi:CAR1(display_short)|uniprotkb:LPH15W(orf name)|uniprotkb:YPL111W(locus name)	psi-mi:"MI:0415"(enzymatic study)	El et al. (2003)	pubmed:12679340|imex:IM-19025	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0414"(enzymatic reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2355831|imex:IM-19025-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_015214.1|sgd:S000006032|dip:DIP-1224N|mint:P00812|ensemblfungi:YPL111W(gene)|ensemblfungi:YPL111W_mRNA(transcript)|go:"GO:0000050"(urea cycle)|go:"GO:0004053"(arginase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019547"(arginine catabolic process to ornithine)|go:"GO:0030145"(manganese ion binding)|go:"GO:0043332"(mating projection tip)|go:"GO:0090368"(regulation of ornithine metabolic process)|go:"GO:0090369"(ornithine carbamoyltransferase inhibitor activity)|interpro:IPR006035(Ureohydrolase)|interpro:IPR014033(Arginase, subgroup)|interpro:IPR020855|interpro:IPR023696|reactome:R-SCE-6798695|reactome:R-SCE-70635	go:"GO:0004585"(ornithine carbamoyltransferase activity)	-	crc64:A5979DC9F1FDFF2E	figure legend:Fig. 7, Table 2|comment:Mutations inhibit CAR1 binding to ARG3 and thus prevent the inhibition of ornithine carbamoyltransferase activity.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/19	2014/10/16	-	rogid:XYywV9u8CT00GEzQ/csjxdv/K/8559292	intact-crc:531486AEC44EBFEB	false	-	mutation decreasing interaction:321-321,326-326	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:18257"	uniprotkb:P00812	intact:EBI-2355725	intact:EBI-2856|uniprotkb:D6W3Q6|ensemblfungi:YPL111W	psi-mi:ornithine(display_short)|psi-mi:"CHEBI:18257"(display_long)	psi-mi:argi_yeast(display_long)|uniprotkb:CAR1(gene name)|psi-mi:CAR1(display_short)|uniprotkb:LPH15W(orf name)|uniprotkb:YPL111W(locus name)	psi-mi:"MI:0415"(enzymatic study)	El et al. (2003)	pubmed:12679340|imex:IM-19025	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0414"(enzymatic reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2355831|imex:IM-19025-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_015214.1|sgd:S000006032|dip:DIP-1224N|mint:P00812|ensemblfungi:YPL111W(gene)|ensemblfungi:YPL111W_mRNA(transcript)|go:"GO:0000050"(urea cycle)|go:"GO:0004053"(arginase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019547"(arginine catabolic process to ornithine)|go:"GO:0030145"(manganese ion binding)|go:"GO:0043332"(mating projection tip)|go:"GO:0090368"(regulation of ornithine metabolic process)|go:"GO:0090369"(ornithine carbamoyltransferase inhibitor activity)|interpro:IPR006035(Ureohydrolase)|interpro:IPR014033(Arginase, subgroup)|interpro:IPR020855|interpro:IPR023696|reactome:R-SCE-6798695|reactome:R-SCE-70635	go:"GO:0004585"(ornithine carbamoyltransferase activity)	-	crc64:A5979DC9F1FDFF2E	figure legend:Fig. 7, Table 2|comment:Mutations inhibit CAR1 binding to ARG3 and thus prevent the inhibition of ornithine carbamoyltransferase activity.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/19	2014/10/16	-	rogid:XYywV9u8CT00GEzQ/csjxdv/K/8559292	intact-crc:531486AEC44EBFEB	false	-	mutation decreasing interaction:321-321,326-326	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P00812	uniprotkb:P05150	intact:EBI-2856|uniprotkb:D6W3Q6|ensemblfungi:YPL111W	intact:EBI-12712|uniprotkb:D6VW96|ensemblfungi:YJL088W	psi-mi:argi_yeast(display_long)|uniprotkb:CAR1(gene name)|psi-mi:CAR1(display_short)|uniprotkb:LPH15W(orf name)|uniprotkb:YPL111W(locus name)	psi-mi:otc_yeast(display_long)|uniprotkb:ARG3(gene name)|psi-mi:ARG3(display_short)|uniprotkb:YJL088W(locus name)|uniprotkb:J0924(orf name)|uniprotkb:Ornithine transcarbamylase(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	El et al. (2003)	pubmed:12679340|imex:IM-19025	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0414"(enzymatic reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2355831|imex:IM-19025-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_015214.1|sgd:S000006032|dip:DIP-1224N|mint:P00812|ensemblfungi:YPL111W(gene)|ensemblfungi:YPL111W_mRNA(transcript)|go:"GO:0000050"(urea cycle)|go:"GO:0004053"(arginase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019547"(arginine catabolic process to ornithine)|go:"GO:0030145"(manganese ion binding)|go:"GO:0043332"(mating projection tip)|go:"GO:0090368"(regulation of ornithine metabolic process)|go:"GO:0090369"(ornithine carbamoyltransferase inhibitor activity)|interpro:IPR006035(Ureohydrolase)|interpro:IPR014033(Arginase, subgroup)|interpro:IPR020855|interpro:IPR023696|reactome:R-SCE-6798695|reactome:R-SCE-70635	go:"GO:0019240"(citrulline biosynthetic process)|go:"GO:0005739"(mitochondrion)|go:"GO:0042450"(arginine biosynthetic process via ornithine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR002292(Ornithine carbamoyltransferase)|interpro:IPR006130(Aspartate/ornithine carbamoyltransferase)|go:"GO:0005829"(cytosol)|interpro:IPR006131(Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region)|interpro:IPR006132(Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding)|interpro:IPR036901|reactome:R-SCE-1268020|reactome:R-SCE-70635|go:"GO:0006526"(arginine biosynthetic process)|go:"GO:0016597"(amino acid binding)|ensemblfungi:YJL088W(gene)|ensemblfungi:YJL088W_mRNA(transcript)|go:"GO:0004585"(ornithine carbamoyltransferase activity)|refseq:NP_012447.1|sgd:S000003624|mint:P05150|dip:DIP-8093N	go:"GO:0004585"(ornithine carbamoyltransferase activity)	crc64:A5979DC9F1FDFF2E	crc64:6EBB6598FA93C59E	figure legend:Fig. 7, Table 2|comment:Mutations inhibit CAR1 binding to ARG3 and thus prevent the inhibition of ornithine carbamoyltransferase activity.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/19	2014/10/16	rogid:XYywV9u8CT00GEzQ/csjxdv/K/8559292	rogid:wDJ7Bk7AOiw+vOkhz++aG0UA0JM559292	intact-crc:531486AEC44EBFEB	false	mutation decreasing interaction:321-321,326-326	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P00812	uniprotkb:P05150	intact:EBI-2856|uniprotkb:D6W3Q6|ensemblfungi:YPL111W	intact:EBI-12712|uniprotkb:D6VW96|ensemblfungi:YJL088W	psi-mi:argi_yeast(display_long)|uniprotkb:CAR1(gene name)|psi-mi:CAR1(display_short)|uniprotkb:LPH15W(orf name)|uniprotkb:YPL111W(locus name)	psi-mi:otc_yeast(display_long)|uniprotkb:ARG3(gene name)|psi-mi:ARG3(display_short)|uniprotkb:YJL088W(locus name)|uniprotkb:J0924(orf name)|uniprotkb:Ornithine transcarbamylase(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	El et al. (2003)	pubmed:12679340|imex:IM-19025	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2355816|imex:IM-19025-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_015214.1|sgd:S000006032|dip:DIP-1224N|mint:P00812|ensemblfungi:YPL111W(gene)|ensemblfungi:YPL111W_mRNA(transcript)|go:"GO:0000050"(urea cycle)|go:"GO:0004053"(arginase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019547"(arginine catabolic process to ornithine)|go:"GO:0030145"(manganese ion binding)|go:"GO:0043332"(mating projection tip)|go:"GO:0090368"(regulation of ornithine metabolic process)|go:"GO:0090369"(ornithine carbamoyltransferase inhibitor activity)|interpro:IPR006035(Ureohydrolase)|interpro:IPR014033(Arginase, subgroup)|interpro:IPR020855|interpro:IPR023696|reactome:R-SCE-6798695|reactome:R-SCE-70635	go:"GO:0019240"(citrulline biosynthetic process)|go:"GO:0005739"(mitochondrion)|go:"GO:0042450"(arginine biosynthetic process via ornithine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR002292(Ornithine carbamoyltransferase)|interpro:IPR006130(Aspartate/ornithine carbamoyltransferase)|go:"GO:0005829"(cytosol)|interpro:IPR006131(Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region)|interpro:IPR006132(Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding)|interpro:IPR036901|reactome:R-SCE-1268020|reactome:R-SCE-70635|go:"GO:0006526"(arginine biosynthetic process)|go:"GO:0016597"(amino acid binding)|ensemblfungi:YJL088W(gene)|ensemblfungi:YJL088W_mRNA(transcript)|go:"GO:0004585"(ornithine carbamoyltransferase activity)|refseq:NP_012447.1|sgd:S000003624|mint:P05150|dip:DIP-8093N	-	crc64:A5979DC9F1FDFF2E	crc64:6EBB6598FA93C59E	figure legend:Figs. 3, 7B and 7C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/06/19	2014/10/16	rogid:XYywV9u8CT00GEzQ/csjxdv/K/8559292	rogid:wDJ7Bk7AOiw+vOkhz++aG0UA0JM559292	intact-crc:30DE7706059947AC|rigid:MAvIMIMX0eAIxvTiVleGaj5p6Mk	false	mutation decreasing interaction:321-321,326-326	mutation decreasing interaction:182-182	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)