#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P32939 uniprotkb:Q04934 intact:EBI-29509|uniprotkb:D6VZH4|ensemblfungi:YML001W intact:EBI-35255|uniprotkb:D6VSL1|ensemblfungi:YDR229W psi-mi:ypt7_yeast(display_long)|uniprotkb:YPT7(gene name)|psi-mi:YPT7(display_short)|uniprotkb:VAM4(gene name synonym)|uniprotkb:Vacuolar morphology protein 4(gene name synonym)|uniprotkb:YM8270.02(orf name)|uniprotkb:YML001W(locus name) psi-mi:ivy1_yeast(display_long)|uniprotkb:IVY1(gene name)|psi-mi:IVY1(display_short)|uniprotkb:Interaction with VPS33 and YPT7 protein 1(gene name synonym)|uniprotkb:YDR229W(locus name)|uniprotkb:YD9934.14(orf name) psi-mi:"MI:0096"(pull down) Lazar et al. (2002) pubmed:12553664|imex:IM-20252 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2216228|imex:IM-20252-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_013713.1|sgd:S000004460|dip:DIP-1735N|mint:P32939|ensemblfungi:YML001W(gene)|ensemblfungi:YML001W_mRNA(transcript)|go:"GO:0000011"(vacuole inheritance)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005773"(vacuole)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0032258"(cytoplasm to vacuole transport by the Cvt pathway)|go:"GO:0032889"(regulation of vacuole fusion, non-autophagic)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0072665"(protein localization to vacuole)|go:"GO:1990816"(vacuole-mitochondrion membrane contact site)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|rcsb pdb:1KY2|rcsb pdb:1KY3|rcsb pdb:4PHF|rcsb pdb:4PHG|rcsb pdb:4PHH|reactome:R-SCE-6798695|reactome:R-SCE-8854214|reactome:R-SCE-8873719|reactome:R-SCE-8876198|reactome:R-SCE-9013405|reactome:R-SCE-9013406 sgd:S000002637|refseq:NP_010515.3|dip:DIP-2957N|ensemblfungi:YDR229W(gene)|ensemblfungi:YDR229W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005543"(phospholipid binding)|go:"GO:0042144"(vacuole fusion, non-autophagic)|go:"GO:0042802"(identical protein binding)|interpro:IPR027267|interpro:IPR037470 - crc64:0E2B72BDA7F7CEE5 crc64:2DB24DD88BED4522 figure legend:Figure 3a|figure legend:"Ivy1p (tagged with C-terminal HA-epitopes) interacts with bacterially produced recombinant GST-Ypt7p and GST-Ypt7(T22N)p but not with unmodified GST."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/02/09 2014/10/16 rogid:ZR2uZTxqTXnSamelDJbMoEI2af8559292 rogid:uG0R44hpyUsrqedxOzZhfYAr9GQ559292 intact-crc:68A5D0391DCEB660|rigid:MLuJcJI4A4X0ijnxA4XnCyo5ys0 false glutathione s tranferase tag:?-? ha tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q99260 uniprotkb:Q04934 intact:EBI-29503|uniprotkb:D6VYQ8|ensemblfungi:YLR262C intact:EBI-35255|uniprotkb:D6VSL1|ensemblfungi:YDR229W psi-mi:ypt6_yeast(display_long)|uniprotkb:L8479.11(orf name)|uniprotkb:YLR262C(locus name)|uniprotkb:YPT6(gene name)|psi-mi:YPT6(display_short) psi-mi:ivy1_yeast(display_long)|uniprotkb:IVY1(gene name)|psi-mi:IVY1(display_short)|uniprotkb:Interaction with VPS33 and YPT7 protein 1(gene name synonym)|uniprotkb:YDR229W(locus name)|uniprotkb:YD9934.14(orf name) psi-mi:"MI:0096"(pull down) Lazar et al. (2002) pubmed:12553664|imex:IM-20252 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2216359|imex:IM-20252-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_013363.1|sgd:S000004252|dip:DIP-5577N|mint:Q99260|ensemblfungi:YLR262C(gene)|ensemblfungi:YLR262C_mRNA(transcript)|go:"GO:0000301"(retrograde transport, vesicle recycling within Golgi)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0012505"(endomembrane system)|go:"GO:0016236"(macroautophagy)|go:"GO:0032258"(cytoplasm to vacuole transport by the Cvt pathway)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0034629"|go:"GO:0042147"(retrograde transport, endosome to Golgi)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|reactome:R-SCE-6798695|reactome:R-SCE-6811440|reactome:R-SCE-8873719|reactome:R-SCE-8876198 sgd:S000002637|refseq:NP_010515.3|dip:DIP-2957N|ensemblfungi:YDR229W(gene)|ensemblfungi:YDR229W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005543"(phospholipid binding)|go:"GO:0042144"(vacuole fusion, non-autophagic)|go:"GO:0042802"(identical protein binding)|interpro:IPR027267|interpro:IPR037470 - crc64:A8E6211FF24FAE0B crc64:2DB24DD88BED4522 figure legend:Figure 3c|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/02/09 2014/10/16 rogid:J/SeVhLd4mnvD5QEdkpsXWUH1rU559292 rogid:uG0R44hpyUsrqedxOzZhfYAr9GQ559292 intact-crc:DFABCD2AF9085BFA|rigid:/e15yIFf7Q/rw869Jf7MAFTEr94 false glutathione s tranferase tag:?-? ha tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P20795 uniprotkb:Q04934 intact:EBI-20395|uniprotkb:D6VZ31|ensemblfungi:YLR396C intact:EBI-35255|uniprotkb:D6VSL1|ensemblfungi:YDR229W psi-mi:vps33_yeast(display_long)|uniprotkb:VPS33(gene name)|psi-mi:VPS33(display_short)|uniprotkb:SLP1(gene name synonym)|uniprotkb:Protein SLP1(gene name synonym)|uniprotkb:Vacuolar morphogenesis protein 5(gene name synonym)|uniprotkb:VAM5(gene name synonym)|uniprotkb:L8084.15(orf name)|uniprotkb:YLR396C(locus name) psi-mi:ivy1_yeast(display_long)|uniprotkb:IVY1(gene name)|psi-mi:IVY1(display_short)|uniprotkb:Interaction with VPS33 and YPT7 protein 1(gene name synonym)|uniprotkb:YDR229W(locus name)|uniprotkb:YD9934.14(orf name) psi-mi:"MI:0096"(pull down) Lazar et al. (2002) pubmed:12553664|imex:IM-20252 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2216368|imex:IM-20252-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) sgd:S000004388|refseq:NP_013500.3|ensemblfungi:YLR396C(gene)|ensemblfungi:YLR396C_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005773"(vacuole)|go:"GO:0005829"(cytosol)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007033"(vacuole organization)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0035542"(regulation of SNARE complex assembly)|go:"GO:0042144"(vacuole fusion, non-autophagic)|go:"GO:0048278"(vesicle docking)|go:"GO:0051469"(vesicle fusion with vacuole)|go:"GO:0099022"(vesicle tethering)|interpro:IPR001619(Sec1-like protein)|interpro:IPR027121|interpro:IPR027482|interpro:IPR036045|interpro:IPR043127|interpro:IPR043155|go:"GO:0030897"(HOPS complex)|go:"GO:0033263"(CORVET complex)|dip:DIP-5910N|mint:P20795 sgd:S000002637|refseq:NP_010515.3|dip:DIP-2957N|ensemblfungi:YDR229W(gene)|ensemblfungi:YDR229W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005543"(phospholipid binding)|go:"GO:0042144"(vacuole fusion, non-autophagic)|go:"GO:0042802"(identical protein binding)|interpro:IPR027267|interpro:IPR037470 - crc64:ED78DF55109C20E7 crc64:2DB24DD88BED4522 figure legend:Figure 3c|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/02/09 2014/10/16 rogid:dvU4L6IiTp4TrzhQXye070fL6q0559292 rogid:uG0R44hpyUsrqedxOzZhfYAr9GQ559292 intact-crc:C18A0CF96B50A5AB|rigid:nxq8GIC7QxVRV1EGE8SW3eD3910 false glutathione s tranferase tag:?-? ha tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q04934 uniprotkb:Q04934 intact:EBI-35255|uniprotkb:D6VSL1|ensemblfungi:YDR229W intact:EBI-35255|uniprotkb:D6VSL1|ensemblfungi:YDR229W psi-mi:ivy1_yeast(display_long)|uniprotkb:IVY1(gene name)|psi-mi:IVY1(display_short)|uniprotkb:Interaction with VPS33 and YPT7 protein 1(gene name synonym)|uniprotkb:YDR229W(locus name)|uniprotkb:YD9934.14(orf name) psi-mi:ivy1_yeast(display_long)|uniprotkb:IVY1(gene name)|psi-mi:IVY1(display_short)|uniprotkb:Interaction with VPS33 and YPT7 protein 1(gene name synonym)|uniprotkb:YDR229W(locus name)|uniprotkb:YD9934.14(orf name) psi-mi:"MI:0096"(pull down) Lazar et al. (2002) pubmed:12553664|imex:IM-20252 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2216377|imex:IM-20252-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) sgd:S000002637|refseq:NP_010515.3|dip:DIP-2957N|ensemblfungi:YDR229W(gene)|ensemblfungi:YDR229W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005543"(phospholipid binding)|go:"GO:0042144"(vacuole fusion, non-autophagic)|go:"GO:0042802"(identical protein binding)|interpro:IPR027267|interpro:IPR037470 sgd:S000002637|refseq:NP_010515.3|dip:DIP-2957N|ensemblfungi:YDR229W(gene)|ensemblfungi:YDR229W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005543"(phospholipid binding)|go:"GO:0042144"(vacuole fusion, non-autophagic)|go:"GO:0042802"(identical protein binding)|interpro:IPR027267|interpro:IPR037470 - crc64:2DB24DD88BED4522 crc64:2DB24DD88BED4522 figure legend:Figure 3c|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/02/09 2014/10/16 rogid:uG0R44hpyUsrqedxOzZhfYAr9GQ559292 rogid:uG0R44hpyUsrqedxOzZhfYAr9GQ559292 intact-crc:CE369E6000E0DDE5|rigid:zW4Z8GdOWAqIfHfNXdCmVT3X6o4 false glutathione s tranferase tag:?-? ha tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q04934 uniprotkb:P20795 intact:EBI-35255|uniprotkb:D6VSL1|ensemblfungi:YDR229W intact:EBI-20395|uniprotkb:D6VZ31|ensemblfungi:YLR396C psi-mi:ivy1_yeast(display_long)|uniprotkb:IVY1(gene name)|psi-mi:IVY1(display_short)|uniprotkb:Interaction with VPS33 and YPT7 protein 1(gene name synonym)|uniprotkb:YDR229W(locus name)|uniprotkb:YD9934.14(orf name) psi-mi:vps33_yeast(display_long)|uniprotkb:VPS33(gene name)|psi-mi:VPS33(display_short)|uniprotkb:SLP1(gene name synonym)|uniprotkb:Protein SLP1(gene name synonym)|uniprotkb:Vacuolar morphogenesis protein 5(gene name synonym)|uniprotkb:VAM5(gene name synonym)|uniprotkb:L8084.15(orf name)|uniprotkb:YLR396C(locus name) psi-mi:"MI:0096"(pull down) Lazar et al. (2002) pubmed:12553664|imex:IM-20252 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2216386|imex:IM-20252-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) sgd:S000002637|refseq:NP_010515.3|dip:DIP-2957N|ensemblfungi:YDR229W(gene)|ensemblfungi:YDR229W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005543"(phospholipid binding)|go:"GO:0042144"(vacuole fusion, non-autophagic)|go:"GO:0042802"(identical protein binding)|interpro:IPR027267|interpro:IPR037470 sgd:S000004388|refseq:NP_013500.3|ensemblfungi:YLR396C(gene)|ensemblfungi:YLR396C_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005773"(vacuole)|go:"GO:0005829"(cytosol)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007033"(vacuole organization)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0035542"(regulation of SNARE complex assembly)|go:"GO:0042144"(vacuole fusion, non-autophagic)|go:"GO:0048278"(vesicle docking)|go:"GO:0051469"(vesicle fusion with vacuole)|go:"GO:0099022"(vesicle tethering)|interpro:IPR001619(Sec1-like protein)|interpro:IPR027121|interpro:IPR027482|interpro:IPR036045|interpro:IPR043127|interpro:IPR043155|go:"GO:0030897"(HOPS complex)|go:"GO:0033263"(CORVET complex)|dip:DIP-5910N|mint:P20795 - crc64:2DB24DD88BED4522 crc64:ED78DF55109C20E7 figure legend:Figure 3d|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/02/09 2014/10/16 rogid:uG0R44hpyUsrqedxOzZhfYAr9GQ559292 rogid:dvU4L6IiTp4TrzhQXye070fL6q0559292 intact-crc:547D5694253BB8BE|rigid:nxq8GIC7QxVRV1EGE8SW3eD3910 false glutathione s tranferase tag:?-? vsv tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P32609 uniprotkb:P38932 intact:EBI-20208|uniprotkb:Q99229|uniprotkb:D6VSV6|ensemblfungi:YDR323C intact:EBI-20444|uniprotkb:D6VU50|ensemblfungi:YGL095C psi-mi:pep7_yeast(display_long)|uniprotkb:PEP7(gene name)|psi-mi:PEP7(display_short)|uniprotkb:VAC1(gene name synonym)|uniprotkb:Protein VAC1(gene name synonym)|uniprotkb:Vacuolar protein sorting-associated protein 19(gene name synonym)|uniprotkb:Vacuolar protein-targeting protein 19(gene name synonym)|uniprotkb:Carboxypeptidase Y-deficient protein 7(gene name synonym)|uniprotkb:VPL21(gene name synonym)|uniprotkb:VPS19(gene name synonym)|uniprotkb:VPT19(gene name synonym)|uniprotkb:YDR323C(locus name) psi-mi:vps45_yeast(display_long)|uniprotkb:VPS45(gene name)|psi-mi:VPS45(display_short)|uniprotkb:STT10(gene name synonym)|uniprotkb:VPL28(gene name synonym)|uniprotkb:YGL095C(locus name) psi-mi:"MI:0096"(pull down) Lazar et al. (2002) pubmed:12553664|imex:IM-20252 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2216395|imex:IM-20252-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) sgd:S000002731|reactome:R-SCE-983231|ensemblfungi:YDR323C(gene)|ensemblfungi:YDR323C_mRNA(transcript)|go:"GO:0000011"(vacuole inheritance)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005829"(cytosol)|refseq:NP_010610.3|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0010009"(cytoplasmic side of endosome membrane)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR021565|interpro:IPR036531|dip:DIP-5240N sgd:S000003063|refseq:NP_011420.3|ensemblfungi:YGL095C(gene)|ensemblfungi:YGL095C_mRNA(transcript)|go:"GO:0000011"(vacuole inheritance)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0007033"(vacuole organization)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0032258"(cytoplasm to vacuole transport by the Cvt pathway)|go:"GO:0035543"(positive regulation of SNARE complex assembly)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051082"(unfolded protein binding)|interpro:IPR001619(Sec1-like protein)|interpro:IPR027482|interpro:IPR036045|interpro:IPR043127|interpro:IPR043154|reactome:R-SCE-983231|dip:DIP-2693N|mint:P38932 - crc64:53C304F1ADA5B7A1 crc64:4AA50D568228228F figure legend:Figure 3e|figure legend:"Vps45-HAp binds to Vac1p (as described by Tall et al., 1999) but not to GST or GST-Ivy1p, confirming the specificity for Vps33p of Ivy1p."|comment:Vac1 is a synonym for the official name PEP7.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/02/09 2014/10/16 rogid:3DMgFRejqoW4RFm8z1mEJI1nMpg559292 rogid:HSNdSBz2AD5AS/nSUjPV02ym8HQ559292 intact-crc:60EAA12A24A62FE1|rigid:p2XBRcaJ15Q6RU3nH9MiP+wYIbk false glutathione s tranferase tag:?-? ha tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q04934 uniprotkb:P01123 intact:EBI-35255|uniprotkb:D6VSL1|ensemblfungi:YDR229W intact:EBI-29496|uniprotkb:D6VTJ2|ensemblfungi:YFL038C psi-mi:ivy1_yeast(display_long)|uniprotkb:IVY1(gene name)|psi-mi:IVY1(display_short)|uniprotkb:Interaction with VPS33 and YPT7 protein 1(gene name synonym)|uniprotkb:YDR229W(locus name)|uniprotkb:YD9934.14(orf name) psi-mi:ypt1_yeast(display_long)|uniprotkb:YFL038C(locus name)|uniprotkb:YPT1(gene name)|psi-mi:YPT1(display_short)|uniprotkb:YP2(gene name synonym)|uniprotkb:Rab GTPase YPT1(gene name synonym)|uniprotkb:Transport GTPase YPT1(gene name synonym)|uniprotkb:Protein YP2(gene name synonym) psi-mi:"MI:0096"(pull down) Lazar et al. (2002) pubmed:12553664|imex:IM-20252 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2266786|imex:IM-20252-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) sgd:S000002637|refseq:NP_010515.3|dip:DIP-2957N|ensemblfungi:YDR229W(gene)|ensemblfungi:YDR229W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005543"(phospholipid binding)|go:"GO:0042144"(vacuole fusion, non-autophagic)|go:"GO:0042802"(identical protein binding)|interpro:IPR027267|interpro:IPR037470 refseq:NP_116615.1|sgd:S000001856|dip:DIP-2019N|mint:P01123|ensemblfungi:YFL038C(gene)|ensemblfungi:YFL038C_mRNA(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005795"(Golgi stack)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0012505"(endomembrane system)|go:"GO:0016236"(macroautophagy)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032258"(cytoplasm to vacuole transport by the Cvt pathway)|go:"GO:0032456"(endocytic recycling)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0034498"(early endosome to Golgi transport)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035494"(SNARE complex disassembly)|go:"GO:0043549"(regulation of kinase activity)|go:"GO:0048194"(Golgi vesicle budding)|go:"GO:0048211"(Golgi vesicle docking)|go:"GO:0061709"(reticulophagy)|go:"GO:0090114"(COPII-coated vesicle budding)|go:"GO:1900101"(regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1990261"(pre-mRNA catabolic process)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|rcsb pdb:1UKV|rcsb pdb:1YZN|rcsb pdb:2BCG|rcsb pdb:3CUE|rcsb pdb:7KMT|reactome:R-SCE-162658|reactome:R-SCE-204005|reactome:R-SCE-6807878|reactome:R-SCE-6811434|reactome:R-SCE-8873719|reactome:R-SCE-8876198 - crc64:2DB24DD88BED4522 crc64:F8C704F6BF2D227B figure legend:Figure 3b|figure legend:"Matrices loaded with GST-Ypt1p (an ER-Golgi transport GTPase) are able to bind minute amounts of Ivy1p when Ypt1p is activated by GTP."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/02/09 2014/10/16 rogid:uG0R44hpyUsrqedxOzZhfYAr9GQ559292 rogid:IMz/iERXs1zvX+wgJ9x7Uk0ovQ8559292 intact-crc:C73A74C6A5B57616|rigid:g7hHb90tmOy/uAFzvMleHr6a1iQ false ha tag:?-? glutathione s tranferase tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P32939 uniprotkb:Q04934 intact:EBI-29509|uniprotkb:D6VZH4|ensemblfungi:YML001W intact:EBI-35255|uniprotkb:D6VSL1|ensemblfungi:YDR229W psi-mi:ypt7_yeast(display_long)|uniprotkb:YPT7(gene name)|psi-mi:YPT7(display_short)|uniprotkb:VAM4(gene name synonym)|uniprotkb:Vacuolar morphology protein 4(gene name synonym)|uniprotkb:YM8270.02(orf name)|uniprotkb:YML001W(locus name) psi-mi:ivy1_yeast(display_long)|uniprotkb:IVY1(gene name)|psi-mi:IVY1(display_short)|uniprotkb:Interaction with VPS33 and YPT7 protein 1(gene name synonym)|uniprotkb:YDR229W(locus name)|uniprotkb:YD9934.14(orf name) psi-mi:"MI:0018"(two hybrid) Lazar et al. (2002) pubmed:12553664|imex:IM-20252 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2216474|imex:IM-20252-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_013713.1|sgd:S000004460|dip:DIP-1735N|mint:P32939|ensemblfungi:YML001W(gene)|ensemblfungi:YML001W_mRNA(transcript)|go:"GO:0000011"(vacuole inheritance)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005773"(vacuole)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0032258"(cytoplasm to vacuole transport by the Cvt pathway)|go:"GO:0032889"(regulation of vacuole fusion, non-autophagic)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0072665"(protein localization to vacuole)|go:"GO:1990816"(vacuole-mitochondrion membrane contact site)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|rcsb pdb:1KY2|rcsb pdb:1KY3|rcsb pdb:4PHF|rcsb pdb:4PHG|rcsb pdb:4PHH|reactome:R-SCE-6798695|reactome:R-SCE-8854214|reactome:R-SCE-8873719|reactome:R-SCE-8876198|reactome:R-SCE-9013405|reactome:R-SCE-9013406 sgd:S000002637|refseq:NP_010515.3|dip:DIP-2957N|ensemblfungi:YDR229W(gene)|ensemblfungi:YDR229W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005543"(phospholipid binding)|go:"GO:0042144"(vacuole fusion, non-autophagic)|go:"GO:0042802"(identical protein binding)|interpro:IPR027267|interpro:IPR037470 - crc64:0E2B72BDA7F7CEE5 crc64:2DB24DD88BED4522 figure legend:Figure 2|figure legend:"Two-hybrid system interactions of Ivy1p. Ivy1p yields positive lacZ assay results with the transport GTPase Ypt7p (wild-type), the mutant GTPases Ypt7(T22N)p (predominantly in the GDP-bound form) and Ypt7(Q68L)p (predominantly in the GTP-bound form), with itself, and with Vps33p."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2009/02/09 2014/10/16 rogid:ZR2uZTxqTXnSamelDJbMoEI2af8559292 rogid:uG0R44hpyUsrqedxOzZhfYAr9GQ559292 intact-crc:44214053B56B5746|rigid:MLuJcJI4A4X0ijnxA4XnCyo5ys0 false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q04934 uniprotkb:Q04934 intact:EBI-35255|uniprotkb:D6VSL1|ensemblfungi:YDR229W intact:EBI-35255|uniprotkb:D6VSL1|ensemblfungi:YDR229W psi-mi:ivy1_yeast(display_long)|uniprotkb:IVY1(gene name)|psi-mi:IVY1(display_short)|uniprotkb:Interaction with VPS33 and YPT7 protein 1(gene name synonym)|uniprotkb:YDR229W(locus name)|uniprotkb:YD9934.14(orf name) psi-mi:ivy1_yeast(display_long)|uniprotkb:IVY1(gene name)|psi-mi:IVY1(display_short)|uniprotkb:Interaction with VPS33 and YPT7 protein 1(gene name synonym)|uniprotkb:YDR229W(locus name)|uniprotkb:YD9934.14(orf name) psi-mi:"MI:0018"(two hybrid) Lazar et al. (2002) pubmed:12553664|imex:IM-20252 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2216493|imex:IM-20252-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) sgd:S000002637|refseq:NP_010515.3|dip:DIP-2957N|ensemblfungi:YDR229W(gene)|ensemblfungi:YDR229W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005543"(phospholipid binding)|go:"GO:0042144"(vacuole fusion, non-autophagic)|go:"GO:0042802"(identical protein binding)|interpro:IPR027267|interpro:IPR037470 sgd:S000002637|refseq:NP_010515.3|dip:DIP-2957N|ensemblfungi:YDR229W(gene)|ensemblfungi:YDR229W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005543"(phospholipid binding)|go:"GO:0042144"(vacuole fusion, non-autophagic)|go:"GO:0042802"(identical protein binding)|interpro:IPR027267|interpro:IPR037470 - crc64:2DB24DD88BED4522 crc64:2DB24DD88BED4522 figure legend:Figure 2|figure legend:Figure 2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2009/02/09 2014/10/16 rogid:uG0R44hpyUsrqedxOzZhfYAr9GQ559292 rogid:uG0R44hpyUsrqedxOzZhfYAr9GQ559292 intact-crc:87108C020EB8039D|rigid:zW4Z8GdOWAqIfHfNXdCmVT3X6o4 false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P20795 uniprotkb:Q04934 intact:EBI-20395|uniprotkb:D6VZ31|ensemblfungi:YLR396C intact:EBI-35255|uniprotkb:D6VSL1|ensemblfungi:YDR229W psi-mi:vps33_yeast(display_long)|uniprotkb:VPS33(gene name)|psi-mi:VPS33(display_short)|uniprotkb:SLP1(gene name synonym)|uniprotkb:Protein SLP1(gene name synonym)|uniprotkb:Vacuolar morphogenesis protein 5(gene name synonym)|uniprotkb:VAM5(gene name synonym)|uniprotkb:L8084.15(orf name)|uniprotkb:YLR396C(locus name) psi-mi:ivy1_yeast(display_long)|uniprotkb:IVY1(gene name)|psi-mi:IVY1(display_short)|uniprotkb:Interaction with VPS33 and YPT7 protein 1(gene name synonym)|uniprotkb:YDR229W(locus name)|uniprotkb:YD9934.14(orf name) psi-mi:"MI:0018"(two hybrid) Lazar et al. (2002) pubmed:12553664|imex:IM-20252 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2216498|imex:IM-20252-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) sgd:S000004388|refseq:NP_013500.3|ensemblfungi:YLR396C(gene)|ensemblfungi:YLR396C_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005773"(vacuole)|go:"GO:0005829"(cytosol)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007033"(vacuole organization)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0035542"(regulation of SNARE complex assembly)|go:"GO:0042144"(vacuole fusion, non-autophagic)|go:"GO:0048278"(vesicle docking)|go:"GO:0051469"(vesicle fusion with vacuole)|go:"GO:0099022"(vesicle tethering)|interpro:IPR001619(Sec1-like protein)|interpro:IPR027121|interpro:IPR027482|interpro:IPR036045|interpro:IPR043127|interpro:IPR043155|go:"GO:0030897"(HOPS complex)|go:"GO:0033263"(CORVET complex)|dip:DIP-5910N|mint:P20795 sgd:S000002637|refseq:NP_010515.3|dip:DIP-2957N|ensemblfungi:YDR229W(gene)|ensemblfungi:YDR229W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005543"(phospholipid binding)|go:"GO:0042144"(vacuole fusion, non-autophagic)|go:"GO:0042802"(identical protein binding)|interpro:IPR027267|interpro:IPR037470 - crc64:ED78DF55109C20E7 crc64:2DB24DD88BED4522 figure legend:Figure 2|figure legend:"Two-hybrid system interactions of Ivy1p. Ivy1p yields positive lacZ assay results with the transport GTPase Ypt7p (wild-type), the mutant GTPases Ypt7(T22N)p (predominantly in the GDP-bound form) and Ypt7(Q68L)p (predominantly in the GTP-bound form), with itself, and with Vps33p."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2009/02/09 2014/10/16 rogid:dvU4L6IiTp4TrzhQXye070fL6q0559292 rogid:uG0R44hpyUsrqedxOzZhfYAr9GQ559292 intact-crc:CC1C473EA24D203A|rigid:nxq8GIC7QxVRV1EGE8SW3eD3910 false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q04934 uniprotkb:P32939 intact:EBI-35255|uniprotkb:D6VSL1|ensemblfungi:YDR229W intact:EBI-29509|uniprotkb:D6VZH4|ensemblfungi:YML001W psi-mi:ivy1_yeast(display_long)|uniprotkb:IVY1(gene name)|psi-mi:IVY1(display_short)|uniprotkb:Interaction with VPS33 and YPT7 protein 1(gene name synonym)|uniprotkb:YDR229W(locus name)|uniprotkb:YD9934.14(orf name) psi-mi:ypt7_yeast(display_long)|uniprotkb:YPT7(gene name)|psi-mi:YPT7(display_short)|uniprotkb:VAM4(gene name synonym)|uniprotkb:Vacuolar morphology protein 4(gene name synonym)|uniprotkb:YM8270.02(orf name)|uniprotkb:YML001W(locus name) psi-mi:"MI:0018"(two hybrid) Lazar et al. (2002) pubmed:12553664|imex:IM-20252 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2216509|imex:IM-20252-10 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) sgd:S000002637|refseq:NP_010515.3|dip:DIP-2957N|ensemblfungi:YDR229W(gene)|ensemblfungi:YDR229W_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005543"(phospholipid binding)|go:"GO:0042144"(vacuole fusion, non-autophagic)|go:"GO:0042802"(identical protein binding)|interpro:IPR027267|interpro:IPR037470 refseq:NP_013713.1|sgd:S000004460|dip:DIP-1735N|mint:P32939|ensemblfungi:YML001W(gene)|ensemblfungi:YML001W_mRNA(transcript)|go:"GO:0000011"(vacuole inheritance)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005773"(vacuole)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0032258"(cytoplasm to vacuole transport by the Cvt pathway)|go:"GO:0032889"(regulation of vacuole fusion, non-autophagic)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0072665"(protein localization to vacuole)|go:"GO:1990816"(vacuole-mitochondrion membrane contact site)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|rcsb pdb:1KY2|rcsb pdb:1KY3|rcsb pdb:4PHF|rcsb pdb:4PHG|rcsb pdb:4PHH|reactome:R-SCE-6798695|reactome:R-SCE-8854214|reactome:R-SCE-8873719|reactome:R-SCE-8876198|reactome:R-SCE-9013405|reactome:R-SCE-9013406 - crc64:2DB24DD88BED4522 crc64:0E2B72BDA7F7CEE5 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2009/02/09 2014/10/16 rogid:uG0R44hpyUsrqedxOzZhfYAr9GQ559292 rogid:ZR2uZTxqTXnSamelDJbMoEI2af8559292 intact-crc:E883D301D08A8B3D|rigid:MLuJcJI4A4X0ijnxA4XnCyo5ys0 false - mutation:22-22 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification)