#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8R1P4	uniprotkb:Q99J83	intact:EBI-8575910|uniprotkb:Q9D3J7|uniprotkb:Q8BPA9|intact:UNK-5524491	intact:EBI-2911848|ensembl:ENSMUSP00000044769	psi-mi:atg10_mouse(display_long)|uniprotkb:Autophagy-related protein 10(gene name synonym)|uniprotkb:Atg10(gene name)|psi-mi:Atg10(display_short)|uniprotkb:Apg10l(gene name synonym)	psi-mi:atg5_mouse(display_long)|uniprotkb:Atg5(gene name)|psi-mi:Atg5(display_short)|uniprotkb:Apg5l(gene name synonym)|uniprotkb:APG5-like(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Mizushima et al. (2002)	pubmed:12482611|imex:IM-15856|mint:MINT-7032599|doi:"10.1016/S0014-5793(02)03739-0"	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8575904|mint:MINT-7032611|imex:IM-15856-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006517389.1|go:"GO:0005829"(cytosol)|go:"GO:0006497"(protein lipidation)|go:"GO:0006914"(autophagy)|go:"GO:0006983"(ER overload response)|go:"GO:0015031"(protein transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0019777"(Atg12 transferase activity)|go:"GO:0031401"(positive regulation of protein modification process)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0061651"(Atg12 conjugating enzyme activity)|reactome:R-MMU-1632852|interpro:IPR007135(Autophagocytosis associated protein, C-terminal)|refseq:NP_080046.3|mint:Q8R1P4|mint:MINT-7032614(identity)	ensembl:ENSMUSG00000038160(gene)|ensembl:ENSMUST00000039286(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002718"(regulation of cytokine production involved in immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006501"(C-terminal protein lipidation)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0009620"(response to fungus)|go:"GO:0034274"(Atg12-Atg5-Atg16 complex)|go:"GO:0035973"(aggrephagy)|go:"GO:0039689"(negative stranded viral RNA replication)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0044804"(autophagy of nucleus)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0048840"(otolith development)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060047"(heart contraction)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061739"(protein lipidation involved in autophagosome assembly)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0071500"(cellular response to nitrosative stress)|go:"GO:0075044"(positive regulation by symbiont of host autophagy)|go:"GO:1902017"(regulation of cilium assembly)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000619"(negative regulation of histone H4-K16 acetylation)|interpro:IPR007239(Autophagy protein 5)|interpro:IPR042526|interpro:IPR042527|mint:Q99J83|reactome:R-MMU-1632852|reactome:R-MMU-5205685|reactome:R-MMU-8934903|refseq:XP_011241410.1|refseq:NP_444299.1|refseq:NP_001300942.1|dip:DIP-46420N|mint:MINT-7032613(identity)	-	comment:mint|function:"Plays a role in autophagy (By similarity). ATG12-conjugating enzyme (E2-like enzyme), likely serves as an ATG5-recognition molecule"	-	figure legend:F1 F2A|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2009/04/14	2014/10/16	rogid:tG3iPDXjTSHWv6wmhWirHsfJZ2s10090	rogid:XNYb541lnGe1mjdDHei6DNhiNfk10090	intact-crc:8B9DF481AA0EB165|rigid:jaqVznv3W8lqmpTr9oXRC6ogHis	false	tag:?-?(MINT-7032620)	tag:?-?(MINT-7032616)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99J83	uniprotkb:Q9CQY1	intact:EBI-2911848|ensembl:ENSMUSP00000044769	intact:EBI-2911788|uniprotkb:Q3TKE5|uniprotkb:Q9D7Y5|ensembl:ENSMUSP00000038489	psi-mi:atg5_mouse(display_long)|uniprotkb:Atg5(gene name)|psi-mi:Atg5(display_short)|uniprotkb:Apg5l(gene name synonym)|uniprotkb:APG5-like(gene name synonym)	psi-mi:atg12_mouse(display_long)|uniprotkb:Atg12(gene name)|psi-mi:Atg12(display_short)|uniprotkb:Apg12(gene name synonym)|uniprotkb:Apg12l(gene name synonym)|uniprotkb:Autophagy-related protein 12(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Mizushima et al. (2002)	pubmed:12482611|imex:IM-15856|mint:MINT-7032599|doi:"10.1016/S0014-5793(02)03739-0"	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8575944|mint:MINT-7032625|imex:IM-15856-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000038160(gene)|ensembl:ENSMUST00000039286(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002718"(regulation of cytokine production involved in immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006501"(C-terminal protein lipidation)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0009620"(response to fungus)|go:"GO:0034274"(Atg12-Atg5-Atg16 complex)|go:"GO:0035973"(aggrephagy)|go:"GO:0039689"(negative stranded viral RNA replication)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0044804"(autophagy of nucleus)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0048840"(otolith development)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060047"(heart contraction)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061739"(protein lipidation involved in autophagosome assembly)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0071500"(cellular response to nitrosative stress)|go:"GO:0075044"(positive regulation by symbiont of host autophagy)|go:"GO:1902017"(regulation of cilium assembly)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000619"(negative regulation of histone H4-K16 acetylation)|interpro:IPR007239(Autophagy protein 5)|interpro:IPR042526|interpro:IPR042527|mint:Q99J83|reactome:R-MMU-1632852|reactome:R-MMU-5205685|reactome:R-MMU-8934903|refseq:XP_011241410.1|refseq:NP_444299.1|refseq:NP_001300942.1|dip:DIP-46420N|mint:MINT-7032631(identity)	go:"GO:0000045"(autophagosome assembly)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006501"(C-terminal protein lipidation)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034274"(Atg12-Atg5-Atg16 complex)|go:"GO:0044804"(autophagy of nucleus)|interpro:IPR007242(Autophagy protein 12)|interpro:IPR029071|mint:Q9CQY1|reactome:R-MMU-1632852|reactome:R-MMU-5205685|reactome:R-MMU-8934903|ensembl:ENSMUSG00000032905(gene)|ensembl:ENSMUST00000035648(transcript)|refseq:NP_080493.2|dip:DIP-57729N|mint:MINT-7032627(identity)	-	-	-	figure legend:F3C|comment:homomint|comment:mint|comment:Interaction requires expression of Apg7 and Apg10|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2009/04/14	2014/10/16	rogid:XNYb541lnGe1mjdDHei6DNhiNfk10090	rogid:VPDzzrLDhtPg3TwA3Qbhr5mB0CQ10090	intact-crc:E14D533738848373|rigid:BPAhBzVXn0Di8L74znt+z+878Q4	false	tag:?-?(MINT-7032632)	tag:?-?(MINT-7032628)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8R1P4	uniprotkb:Q9CQY1	intact:EBI-8575910|uniprotkb:Q9D3J7|uniprotkb:Q8BPA9|intact:UNK-5524491	intact:EBI-2911788|uniprotkb:Q3TKE5|uniprotkb:Q9D7Y5|ensembl:ENSMUSP00000038489	psi-mi:atg10_mouse(display_long)|uniprotkb:Autophagy-related protein 10(gene name synonym)|uniprotkb:Atg10(gene name)|psi-mi:Atg10(display_short)|uniprotkb:Apg10l(gene name synonym)	psi-mi:atg12_mouse(display_long)|uniprotkb:Atg12(gene name)|psi-mi:Atg12(display_short)|uniprotkb:Apg12(gene name synonym)|uniprotkb:Apg12l(gene name synonym)|uniprotkb:Autophagy-related protein 12(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Mizushima et al. (2002)	pubmed:12482611|imex:IM-15856|mint:MINT-7032599|doi:"10.1016/S0014-5793(02)03739-0"	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8575963|mint:MINT-7032660|imex:IM-15856-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006517389.1|go:"GO:0005829"(cytosol)|go:"GO:0006497"(protein lipidation)|go:"GO:0006914"(autophagy)|go:"GO:0006983"(ER overload response)|go:"GO:0015031"(protein transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0019777"(Atg12 transferase activity)|go:"GO:0031401"(positive regulation of protein modification process)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0061651"(Atg12 conjugating enzyme activity)|reactome:R-MMU-1632852|interpro:IPR007135(Autophagocytosis associated protein, C-terminal)|refseq:NP_080046.3|mint:Q8R1P4|mint:MINT-7032662(identity)	go:"GO:0000045"(autophagosome assembly)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006501"(C-terminal protein lipidation)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034274"(Atg12-Atg5-Atg16 complex)|go:"GO:0044804"(autophagy of nucleus)|interpro:IPR007242(Autophagy protein 12)|interpro:IPR029071|mint:Q9CQY1|reactome:R-MMU-1632852|reactome:R-MMU-5205685|reactome:R-MMU-8934903|ensembl:ENSMUSG00000032905(gene)|ensembl:ENSMUST00000035648(transcript)|refseq:NP_080493.2|dip:DIP-57729N|mint:MINT-7032664(identity)	-	comment:mint|function:"Plays a role in autophagy (By similarity). ATG12-conjugating enzyme (E2-like enzyme), likely serves as an ATG5-recognition molecule"	-	figure legend:F2B|comment:homomint|comment:mint|comment:Interaction requires expression of Apg7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2009/04/14	2014/10/16	rogid:tG3iPDXjTSHWv6wmhWirHsfJZ2s10090	rogid:VPDzzrLDhtPg3TwA3Qbhr5mB0CQ10090	intact-crc:3FA651C782F96B58|rigid:irqOooylzjHUNcCMM1+Qn6x1bjQ	false	-	tag:?-?(MINT-7032669)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8R1P4	uniprotkb:Q9CQY1	intact:EBI-8575910|uniprotkb:Q9D3J7|uniprotkb:Q8BPA9|intact:UNK-5524491	intact:EBI-2911788|uniprotkb:Q3TKE5|uniprotkb:Q9D7Y5|ensembl:ENSMUSP00000038489	psi-mi:atg10_mouse(display_long)|uniprotkb:Autophagy-related protein 10(gene name synonym)|uniprotkb:Atg10(gene name)|psi-mi:Atg10(display_short)|uniprotkb:Apg10l(gene name synonym)	psi-mi:atg12_mouse(display_long)|uniprotkb:Atg12(gene name)|psi-mi:Atg12(display_short)|uniprotkb:Apg12(gene name synonym)|uniprotkb:Apg12l(gene name synonym)|uniprotkb:Autophagy-related protein 12(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Mizushima et al. (2002)	pubmed:12482611|imex:IM-15856|mint:MINT-7032599|doi:"10.1016/S0014-5793(02)03739-0"	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8575986|mint:MINT-7032677|imex:IM-15856-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006517389.1|go:"GO:0005829"(cytosol)|go:"GO:0006497"(protein lipidation)|go:"GO:0006914"(autophagy)|go:"GO:0006983"(ER overload response)|go:"GO:0015031"(protein transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0019777"(Atg12 transferase activity)|go:"GO:0031401"(positive regulation of protein modification process)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0061651"(Atg12 conjugating enzyme activity)|reactome:R-MMU-1632852|interpro:IPR007135(Autophagocytosis associated protein, C-terminal)|refseq:NP_080046.3|mint:Q8R1P4|mint:MINT-7032679(identity)	go:"GO:0000045"(autophagosome assembly)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006501"(C-terminal protein lipidation)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034274"(Atg12-Atg5-Atg16 complex)|go:"GO:0044804"(autophagy of nucleus)|interpro:IPR007242(Autophagy protein 12)|interpro:IPR029071|mint:Q9CQY1|reactome:R-MMU-1632852|reactome:R-MMU-5205685|reactome:R-MMU-8934903|ensembl:ENSMUSG00000032905(gene)|ensembl:ENSMUST00000035648(transcript)|refseq:NP_080493.2|dip:DIP-57729N|mint:MINT-7032683(identity)	-	comment:mint|function:"Plays a role in autophagy (By similarity). ATG12-conjugating enzyme (E2-like enzyme), likely serves as an ATG5-recognition molecule"	-	figure legend:F2B|comment:homomint|comment:mint|comment:Interaction requires expression of Apg7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2009/04/14	2014/10/16	rogid:tG3iPDXjTSHWv6wmhWirHsfJZ2s10090	rogid:VPDzzrLDhtPg3TwA3Qbhr5mB0CQ10090	intact-crc:CE7D71CF5FC74CBF|rigid:irqOooylzjHUNcCMM1+Qn6x1bjQ	false	-	tag:?-?(MINT-7032684)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8R1P4	uniprotkb:Q9D906	intact:EBI-8575910|uniprotkb:Q9D3J7|uniprotkb:Q8BPA9|intact:UNK-5524491	intact:EBI-8576027|ensembl:ENSMUSP00000032457|ensembl:ENSMUSP00000138137|ensembl:ENSMUSP00000138651|intact:MINT-4615793|uniprotkb:Q3TCD9|uniprotkb:Q8K4Q5	psi-mi:atg10_mouse(display_long)|uniprotkb:Autophagy-related protein 10(gene name synonym)|uniprotkb:Atg10(gene name)|psi-mi:Atg10(display_short)|uniprotkb:Apg10l(gene name synonym)	psi-mi:atg7_mouse(display_long)|uniprotkb:Atg7(gene name)|psi-mi:Atg7(display_short)|uniprotkb:Apg7l(gene name synonym)|uniprotkb:ATG12-activating enzyme E1 ATG7(gene name synonym)|uniprotkb:Autophagy-related protein 7(gene name synonym)|uniprotkb:Ubiquitin-activating enzyme E1-like protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Mizushima et al. (2002)	pubmed:12482611|imex:IM-15856|mint:MINT-7032599|doi:"10.1016/S0014-5793(02)03739-0"	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8576074|mint:MINT-7032707|imex:IM-15856-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006517389.1|go:"GO:0005829"(cytosol)|go:"GO:0006497"(protein lipidation)|go:"GO:0006914"(autophagy)|go:"GO:0006983"(ER overload response)|go:"GO:0015031"(protein transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0019777"(Atg12 transferase activity)|go:"GO:0031401"(positive regulation of protein modification process)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0061651"(Atg12 conjugating enzyme activity)|reactome:R-MMU-1632852|interpro:IPR007135(Autophagocytosis associated protein, C-terminal)|refseq:NP_080046.3|mint:Q8R1P4|mint:MINT-7032713(identity)	refseq:XP_006506772.1|refseq:XP_006506773.1|refseq:XP_011239796.1|refseq:XP_011239797.1|ensembl:ENSMUSG00000030314(gene)|ensembl:ENSMUST00000032457(transcript)|ensembl:ENSMUST00000182793(transcript)|ensembl:ENSMUST00000182902(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001889"(liver development)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006497"(protein lipidation)|go:"GO:0006501"(C-terminal protein lipidation)|go:"GO:0006914"(autophagy)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0006996"(organelle organization)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007628"(adult walking behavior)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0015031"(protein transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0019778"(Atg12 activating enzyme activity)|go:"GO:0019779"(Atg8 activating enzyme activity)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0021860"(pyramidal neuron development)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030424"(axon)|go:"GO:0031175"(neuron projection development)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031401"(positive regulation of protein modification process)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0039689"(negative stranded viral RNA replication)|go:"GO:0042594"(response to starvation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044805"(late nucleophagy)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050877"(nervous system process)|go:"GO:0051607"(defense response to virus)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060284"(regulation of cell development)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061024"(membrane organization)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0071455"(cellular response to hyperoxia)|go:"GO:0075044"(positive regulation by symbiont of host autophagy)|go:"GO:0080144"(amino acid homeostasis)|go:"GO:0090155"(negative regulation of sphingolipid biosynthetic process)|go:"GO:0090156"(cellular sphingolipid homeostasis)|go:"GO:0090298"(negative regulation of mitochondrial DNA replication)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1903706"(regulation of hemopoiesis)|go:"GO:2000619"(negative regulation of histone H4-K16 acetylation)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR006285(E1-like protein-activating enzyme Gsa7p/Apg7p)|interpro:IPR032197|interpro:IPR035985|interpro:IPR042522|interpro:IPR042523|mint:Q9D906|reactome:R-MMU-1632852|reactome:R-MMU-6798695|reactome:R-MMU-983168|refseq:NP_001240646.1|refseq:NP_001240647.1|refseq:NP_083111.1|mint:MINT-7032709(identity)	-	comment:mint|function:"Plays a role in autophagy (By similarity). ATG12-conjugating enzyme (E2-like enzyme), likely serves as an ATG5-recognition molecule"	function:"Functions as an E1 enzyme essential for multisubstrates such as GABARAPL1 and ATG12. Forms intermediate conjugates with GABARAPL1 (GABARAPL2, GABARAP or MAP1ALC3). Formation of the final GABARAPL1-PE conjugate is essential for autophagy"|comment:mint	figure legend:F2A|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2009/04/14	2014/10/16	rogid:tG3iPDXjTSHWv6wmhWirHsfJZ2s10090	rogid:XFOf/olcXdEwIzAKsHElXkdQa3A10090	intact-crc:34CD189E220B29B4|rigid:sKFcg9NfJYj8+IrtM7l3MfTEtT8	false	tag:?-?(MINT-7032714)	tag:?-?(MINT-7032710)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8R1P4	uniprotkb:Q99J83	intact:EBI-8575910|uniprotkb:Q9D3J7|uniprotkb:Q8BPA9|intact:UNK-5524491	intact:EBI-2911848|ensembl:ENSMUSP00000044769	psi-mi:atg10_mouse(display_long)|uniprotkb:Autophagy-related protein 10(gene name synonym)|uniprotkb:Atg10(gene name)|psi-mi:Atg10(display_short)|uniprotkb:Apg10l(gene name synonym)	psi-mi:atg5_mouse(display_long)|uniprotkb:Atg5(gene name)|psi-mi:Atg5(display_short)|uniprotkb:Apg5l(gene name synonym)|uniprotkb:APG5-like(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Mizushima et al. (2002)	pubmed:12482611|imex:IM-15856|mint:MINT-7032599|doi:"10.1016/S0014-5793(02)03739-0"	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8576009|mint:MINT-7032693|imex:IM-15856-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006517389.1|go:"GO:0005829"(cytosol)|go:"GO:0006497"(protein lipidation)|go:"GO:0006914"(autophagy)|go:"GO:0006983"(ER overload response)|go:"GO:0015031"(protein transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0019777"(Atg12 transferase activity)|go:"GO:0031401"(positive regulation of protein modification process)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0061651"(Atg12 conjugating enzyme activity)|reactome:R-MMU-1632852|interpro:IPR007135(Autophagocytosis associated protein, C-terminal)|refseq:NP_080046.3|mint:Q8R1P4|mint:MINT-7032695(identity)	ensembl:ENSMUSG00000038160(gene)|ensembl:ENSMUST00000039286(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002718"(regulation of cytokine production involved in immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006501"(C-terminal protein lipidation)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0009620"(response to fungus)|go:"GO:0034274"(Atg12-Atg5-Atg16 complex)|go:"GO:0035973"(aggrephagy)|go:"GO:0039689"(negative stranded viral RNA replication)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0044804"(autophagy of nucleus)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0048840"(otolith development)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060047"(heart contraction)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061739"(protein lipidation involved in autophagosome assembly)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0071500"(cellular response to nitrosative stress)|go:"GO:0075044"(positive regulation by symbiont of host autophagy)|go:"GO:1902017"(regulation of cilium assembly)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000619"(negative regulation of histone H4-K16 acetylation)|interpro:IPR007239(Autophagy protein 5)|interpro:IPR042526|interpro:IPR042527|mint:Q99J83|reactome:R-MMU-1632852|reactome:R-MMU-5205685|reactome:R-MMU-8934903|refseq:XP_011241410.1|refseq:NP_444299.1|refseq:NP_001300942.1|dip:DIP-46420N|mint:MINT-7032699(identity)	-	comment:mint|function:"Plays a role in autophagy (By similarity). ATG12-conjugating enzyme (E2-like enzyme), likely serves as an ATG5-recognition molecule"	-	figure legend:F2A|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2009/04/14	2014/10/16	rogid:tG3iPDXjTSHWv6wmhWirHsfJZ2s10090	rogid:XNYb541lnGe1mjdDHei6DNhiNfk10090	intact-crc:8FA09FC9FD86FE61|rigid:jaqVznv3W8lqmpTr9oXRC6ogHis	false	tag:?-?(MINT-7032696)	tag:?-?(MINT-7032700)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9D906	uniprotkb:Q9CQY1	intact:EBI-8576027|ensembl:ENSMUSP00000032457|ensembl:ENSMUSP00000138137|ensembl:ENSMUSP00000138651|intact:MINT-4615793|uniprotkb:Q3TCD9|uniprotkb:Q8K4Q5	intact:EBI-2911788|uniprotkb:Q3TKE5|uniprotkb:Q9D7Y5|ensembl:ENSMUSP00000038489	psi-mi:atg7_mouse(display_long)|uniprotkb:Atg7(gene name)|psi-mi:Atg7(display_short)|uniprotkb:Apg7l(gene name synonym)|uniprotkb:ATG12-activating enzyme E1 ATG7(gene name synonym)|uniprotkb:Autophagy-related protein 7(gene name synonym)|uniprotkb:Ubiquitin-activating enzyme E1-like protein(gene name synonym)	psi-mi:atg12_mouse(display_long)|uniprotkb:Atg12(gene name)|psi-mi:Atg12(display_short)|uniprotkb:Apg12(gene name synonym)|uniprotkb:Apg12l(gene name synonym)|uniprotkb:Autophagy-related protein 12(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Mizushima et al. (2002)	pubmed:12482611|imex:IM-15856|mint:MINT-7032599|doi:"10.1016/S0014-5793(02)03739-0"	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8576110|mint:MINT-7032732|imex:IM-15856-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006506772.1|refseq:XP_006506773.1|refseq:XP_011239796.1|refseq:XP_011239797.1|ensembl:ENSMUSG00000030314(gene)|ensembl:ENSMUST00000032457(transcript)|ensembl:ENSMUST00000182793(transcript)|ensembl:ENSMUST00000182902(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001889"(liver development)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006497"(protein lipidation)|go:"GO:0006501"(C-terminal protein lipidation)|go:"GO:0006914"(autophagy)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0006996"(organelle organization)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007628"(adult walking behavior)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0015031"(protein transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0019778"(Atg12 activating enzyme activity)|go:"GO:0019779"(Atg8 activating enzyme activity)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0021860"(pyramidal neuron development)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030424"(axon)|go:"GO:0031175"(neuron projection development)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031401"(positive regulation of protein modification process)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0039689"(negative stranded viral RNA replication)|go:"GO:0042594"(response to starvation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044805"(late nucleophagy)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050877"(nervous system process)|go:"GO:0051607"(defense response to virus)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060284"(regulation of cell development)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061024"(membrane organization)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0071455"(cellular response to hyperoxia)|go:"GO:0075044"(positive regulation by symbiont of host autophagy)|go:"GO:0080144"(amino acid homeostasis)|go:"GO:0090155"(negative regulation of sphingolipid biosynthetic process)|go:"GO:0090156"(cellular sphingolipid homeostasis)|go:"GO:0090298"(negative regulation of mitochondrial DNA replication)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1903706"(regulation of hemopoiesis)|go:"GO:2000619"(negative regulation of histone H4-K16 acetylation)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR006285(E1-like protein-activating enzyme Gsa7p/Apg7p)|interpro:IPR032197|interpro:IPR035985|interpro:IPR042522|interpro:IPR042523|mint:Q9D906|reactome:R-MMU-1632852|reactome:R-MMU-6798695|reactome:R-MMU-983168|refseq:NP_001240646.1|refseq:NP_001240647.1|refseq:NP_083111.1|mint:MINT-7032738(identity)	go:"GO:0000045"(autophagosome assembly)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006501"(C-terminal protein lipidation)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034274"(Atg12-Atg5-Atg16 complex)|go:"GO:0044804"(autophagy of nucleus)|interpro:IPR007242(Autophagy protein 12)|interpro:IPR029071|mint:Q9CQY1|reactome:R-MMU-1632852|reactome:R-MMU-5205685|reactome:R-MMU-8934903|ensembl:ENSMUSG00000032905(gene)|ensembl:ENSMUST00000035648(transcript)|refseq:NP_080493.2|dip:DIP-57729N|mint:MINT-7032734(identity)	-	function:"Functions as an E1 enzyme essential for multisubstrates such as GABARAPL1 and ATG12. Forms intermediate conjugates with GABARAPL1 (GABARAPL2, GABARAP or MAP1ALC3). Formation of the final GABARAPL1-PE conjugate is essential for autophagy"|comment:mint	-	figure legend:F2A|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2009/04/14	2014/10/16	rogid:XFOf/olcXdEwIzAKsHElXkdQa3A10090	rogid:VPDzzrLDhtPg3TwA3Qbhr5mB0CQ10090	intact-crc:7433F0CC8F5BBEF2|rigid:D3DM4loLP/sjtxLexeLZbbc6ipE	false	tag:?-?(MINT-7032739)	tag:?-?(MINT-7032735)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9D906	uniprotkb:Q9CQY1	intact:EBI-8576027|ensembl:ENSMUSP00000032457|ensembl:ENSMUSP00000138137|ensembl:ENSMUSP00000138651|intact:MINT-4615793|uniprotkb:Q3TCD9|uniprotkb:Q8K4Q5	intact:EBI-2911788|uniprotkb:Q3TKE5|uniprotkb:Q9D7Y5|ensembl:ENSMUSP00000038489	psi-mi:atg7_mouse(display_long)|uniprotkb:Atg7(gene name)|psi-mi:Atg7(display_short)|uniprotkb:Apg7l(gene name synonym)|uniprotkb:ATG12-activating enzyme E1 ATG7(gene name synonym)|uniprotkb:Autophagy-related protein 7(gene name synonym)|uniprotkb:Ubiquitin-activating enzyme E1-like protein(gene name synonym)	psi-mi:atg12_mouse(display_long)|uniprotkb:Atg12(gene name)|psi-mi:Atg12(display_short)|uniprotkb:Apg12(gene name synonym)|uniprotkb:Apg12l(gene name synonym)|uniprotkb:Autophagy-related protein 12(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Mizushima et al. (2002)	pubmed:12482611|imex:IM-15856|mint:MINT-7032599|doi:"10.1016/S0014-5793(02)03739-0"	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8576128|mint:MINT-7032744|imex:IM-15856-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006506772.1|refseq:XP_006506773.1|refseq:XP_011239796.1|refseq:XP_011239797.1|ensembl:ENSMUSG00000030314(gene)|ensembl:ENSMUST00000032457(transcript)|ensembl:ENSMUST00000182793(transcript)|ensembl:ENSMUST00000182902(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001889"(liver development)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006497"(protein lipidation)|go:"GO:0006501"(C-terminal protein lipidation)|go:"GO:0006914"(autophagy)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0006996"(organelle organization)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007628"(adult walking behavior)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0015031"(protein transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0019778"(Atg12 activating enzyme activity)|go:"GO:0019779"(Atg8 activating enzyme activity)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0021860"(pyramidal neuron development)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030424"(axon)|go:"GO:0031175"(neuron projection development)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031401"(positive regulation of protein modification process)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0039689"(negative stranded viral RNA replication)|go:"GO:0042594"(response to starvation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044805"(late nucleophagy)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050877"(nervous system process)|go:"GO:0051607"(defense response to virus)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060284"(regulation of cell development)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061024"(membrane organization)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0071455"(cellular response to hyperoxia)|go:"GO:0075044"(positive regulation by symbiont of host autophagy)|go:"GO:0080144"(amino acid homeostasis)|go:"GO:0090155"(negative regulation of sphingolipid biosynthetic process)|go:"GO:0090156"(cellular sphingolipid homeostasis)|go:"GO:0090298"(negative regulation of mitochondrial DNA replication)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1903706"(regulation of hemopoiesis)|go:"GO:2000619"(negative regulation of histone H4-K16 acetylation)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR006285(E1-like protein-activating enzyme Gsa7p/Apg7p)|interpro:IPR032197|interpro:IPR035985|interpro:IPR042522|interpro:IPR042523|mint:Q9D906|reactome:R-MMU-1632852|reactome:R-MMU-6798695|reactome:R-MMU-983168|refseq:NP_001240646.1|refseq:NP_001240647.1|refseq:NP_083111.1|mint:MINT-7032750(identity)	go:"GO:0000045"(autophagosome assembly)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006501"(C-terminal protein lipidation)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034274"(Atg12-Atg5-Atg16 complex)|go:"GO:0044804"(autophagy of nucleus)|interpro:IPR007242(Autophagy protein 12)|interpro:IPR029071|mint:Q9CQY1|reactome:R-MMU-1632852|reactome:R-MMU-5205685|reactome:R-MMU-8934903|ensembl:ENSMUSG00000032905(gene)|ensembl:ENSMUST00000035648(transcript)|refseq:NP_080493.2|dip:DIP-57729N|mint:MINT-7032746(identity)	-	function:"Functions as an E1 enzyme essential for multisubstrates such as GABARAPL1 and ATG12. Forms intermediate conjugates with GABARAPL1 (GABARAPL2, GABARAP or MAP1ALC3). Formation of the final GABARAPL1-PE conjugate is essential for autophagy"|comment:mint	-	figure legend:F2A|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2009/04/14	2014/10/16	rogid:XFOf/olcXdEwIzAKsHElXkdQa3A10090	rogid:VPDzzrLDhtPg3TwA3Qbhr5mB0CQ10090	intact-crc:7665F98DB0462C8A|rigid:D3DM4loLP/sjtxLexeLZbbc6ipE	false	tag:?-?(MINT-7032751)	tag:?-?(MINT-7032747)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9D906	uniprotkb:Q8R1P4	intact:EBI-8576027|ensembl:ENSMUSP00000032457|ensembl:ENSMUSP00000138137|ensembl:ENSMUSP00000138651|intact:MINT-4615793|uniprotkb:Q3TCD9|uniprotkb:Q8K4Q5	intact:EBI-8575910|uniprotkb:Q9D3J7|uniprotkb:Q8BPA9|intact:UNK-5524491	psi-mi:atg7_mouse(display_long)|uniprotkb:Atg7(gene name)|psi-mi:Atg7(display_short)|uniprotkb:Apg7l(gene name synonym)|uniprotkb:ATG12-activating enzyme E1 ATG7(gene name synonym)|uniprotkb:Autophagy-related protein 7(gene name synonym)|uniprotkb:Ubiquitin-activating enzyme E1-like protein(gene name synonym)	psi-mi:atg10_mouse(display_long)|uniprotkb:Autophagy-related protein 10(gene name synonym)|uniprotkb:Atg10(gene name)|psi-mi:Atg10(display_short)|uniprotkb:Apg10l(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Mizushima et al. (2002)	pubmed:12482611|imex:IM-15856|mint:MINT-7032599|doi:"10.1016/S0014-5793(02)03739-0"	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8576092|mint:MINT-7032719|imex:IM-15856-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006506772.1|refseq:XP_006506773.1|refseq:XP_011239796.1|refseq:XP_011239797.1|ensembl:ENSMUSG00000030314(gene)|ensembl:ENSMUST00000032457(transcript)|ensembl:ENSMUST00000182793(transcript)|ensembl:ENSMUST00000182902(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001889"(liver development)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006497"(protein lipidation)|go:"GO:0006501"(C-terminal protein lipidation)|go:"GO:0006914"(autophagy)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0006996"(organelle organization)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007628"(adult walking behavior)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0015031"(protein transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0019778"(Atg12 activating enzyme activity)|go:"GO:0019779"(Atg8 activating enzyme activity)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0021860"(pyramidal neuron development)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030424"(axon)|go:"GO:0031175"(neuron projection development)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031401"(positive regulation of protein modification process)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0039689"(negative stranded viral RNA replication)|go:"GO:0042594"(response to starvation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044805"(late nucleophagy)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050877"(nervous system process)|go:"GO:0051607"(defense response to virus)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060284"(regulation of cell development)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061024"(membrane organization)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0071455"(cellular response to hyperoxia)|go:"GO:0075044"(positive regulation by symbiont of host autophagy)|go:"GO:0080144"(amino acid homeostasis)|go:"GO:0090155"(negative regulation of sphingolipid biosynthetic process)|go:"GO:0090156"(cellular sphingolipid homeostasis)|go:"GO:0090298"(negative regulation of mitochondrial DNA replication)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1903706"(regulation of hemopoiesis)|go:"GO:2000619"(negative regulation of histone H4-K16 acetylation)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR006285(E1-like protein-activating enzyme Gsa7p/Apg7p)|interpro:IPR032197|interpro:IPR035985|interpro:IPR042522|interpro:IPR042523|mint:Q9D906|reactome:R-MMU-1632852|reactome:R-MMU-6798695|reactome:R-MMU-983168|refseq:NP_001240646.1|refseq:NP_001240647.1|refseq:NP_083111.1|mint:MINT-7032721(identity)	refseq:XP_006517389.1|go:"GO:0005829"(cytosol)|go:"GO:0006497"(protein lipidation)|go:"GO:0006914"(autophagy)|go:"GO:0006983"(ER overload response)|go:"GO:0015031"(protein transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0019777"(Atg12 transferase activity)|go:"GO:0031401"(positive regulation of protein modification process)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0061651"(Atg12 conjugating enzyme activity)|reactome:R-MMU-1632852|interpro:IPR007135(Autophagocytosis associated protein, C-terminal)|refseq:NP_080046.3|mint:Q8R1P4|mint:MINT-7032725(identity)	-	function:"Functions as an E1 enzyme essential for multisubstrates such as GABARAPL1 and ATG12. Forms intermediate conjugates with GABARAPL1 (GABARAPL2, GABARAP or MAP1ALC3). Formation of the final GABARAPL1-PE conjugate is essential for autophagy"|comment:mint	comment:mint|function:"Plays a role in autophagy (By similarity). ATG12-conjugating enzyme (E2-like enzyme), likely serves as an ATG5-recognition molecule"	figure legend:F2A|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2009/04/14	2014/10/16	rogid:XFOf/olcXdEwIzAKsHElXkdQa3A10090	rogid:tG3iPDXjTSHWv6wmhWirHsfJZ2s10090	intact-crc:62E27B2DB7BBDFB5|rigid:sKFcg9NfJYj8+IrtM7l3MfTEtT8	false	tag:?-?(MINT-7032722)	tag:?-?(MINT-7032726)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99J83	uniprotkb:Q9CQY1	intact:EBI-2911848|ensembl:ENSMUSP00000044769	intact:EBI-2911788|uniprotkb:Q3TKE5|uniprotkb:Q9D7Y5|ensembl:ENSMUSP00000038489	psi-mi:atg5_mouse(display_long)|uniprotkb:Atg5(gene name)|psi-mi:Atg5(display_short)|uniprotkb:Apg5l(gene name synonym)|uniprotkb:APG5-like(gene name synonym)	psi-mi:atg12_mouse(display_long)|uniprotkb:Atg12(gene name)|psi-mi:Atg12(display_short)|uniprotkb:Apg12(gene name synonym)|uniprotkb:Apg12l(gene name synonym)|uniprotkb:Autophagy-related protein 12(gene name synonym)	psi-mi:"MI:0401"(biochemical)	Mizushima et al. (2002)	pubmed:12482611|imex:IM-15856|mint:MINT-7032599|doi:"10.1016/S0014-5793(02)03739-0"	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8576156|mint:MINT-7032642|imex:IM-15856-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000038160(gene)|ensembl:ENSMUST00000039286(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002718"(regulation of cytokine production involved in immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006501"(C-terminal protein lipidation)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0009620"(response to fungus)|go:"GO:0034274"(Atg12-Atg5-Atg16 complex)|go:"GO:0035973"(aggrephagy)|go:"GO:0039689"(negative stranded viral RNA replication)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0044804"(autophagy of nucleus)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0048840"(otolith development)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060047"(heart contraction)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061739"(protein lipidation involved in autophagosome assembly)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0071500"(cellular response to nitrosative stress)|go:"GO:0075044"(positive regulation by symbiont of host autophagy)|go:"GO:1902017"(regulation of cilium assembly)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000619"(negative regulation of histone H4-K16 acetylation)|interpro:IPR007239(Autophagy protein 5)|interpro:IPR042526|interpro:IPR042527|mint:Q99J83|reactome:R-MMU-1632852|reactome:R-MMU-5205685|reactome:R-MMU-8934903|refseq:XP_011241410.1|refseq:NP_444299.1|refseq:NP_001300942.1|dip:DIP-46420N|mint:MINT-7032648(identity)	go:"GO:0000045"(autophagosome assembly)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006501"(C-terminal protein lipidation)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034274"(Atg12-Atg5-Atg16 complex)|go:"GO:0044804"(autophagy of nucleus)|interpro:IPR007242(Autophagy protein 12)|interpro:IPR029071|mint:Q9CQY1|reactome:R-MMU-1632852|reactome:R-MMU-5205685|reactome:R-MMU-8934903|ensembl:ENSMUSG00000032905(gene)|ensembl:ENSMUST00000035648(transcript)|refseq:NP_080493.2|dip:DIP-57729N|mint:MINT-7032644(identity)	-	-	-	figure legend:F4|comment:homomint|comment:mint|comment:Interaction requires expression of Apg7 and Apg10|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2009/04/14	2014/10/16	rogid:XNYb541lnGe1mjdDHei6DNhiNfk10090	rogid:VPDzzrLDhtPg3TwA3Qbhr5mB0CQ10090	intact-crc:C8E95D84E1BCC008|rigid:BPAhBzVXn0Di8L74znt+z+878Q4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)