#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P35169	uniprotkb:P38873	intact:EBI-19374|uniprotkb:D6VWN7|ensemblfungi:YJR066W	intact:EBI-24864|uniprotkb:D3DLD4|ensemblfungi:YHR186C	psi-mi:tor1_yeast(display_long)|uniprotkb:DRR1(gene name synonym)|uniprotkb:TOR1(gene name)|psi-mi:TOR1(display_short)|uniprotkb:YJR066W(locus name)|uniprotkb:J1803(orf name)|uniprotkb:Phosphatidylinositol kinase homolog TOR1(gene name synonym)|uniprotkb:Target of rapamycin kinase 1(gene name synonym)|uniprotkb:Dominant rapamycin resistance protein 1(gene name synonym)	psi-mi:kog1_yeast(display_long)|uniprotkb:Kontroller of growth protein 1(gene name synonym)|uniprotkb:Local anesthetic-sensitive protein 24(gene name synonym)|uniprotkb:YHR186C(locus name)|uniprotkb:KOG1(gene name)|psi-mi:KOG1(display_short)|uniprotkb:LAS24(gene name synonym)|uniprotkb:H9998.14(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Loewith et al. (2002)	pubmed:12408816|imex:IM-20364	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2434631|imex:IM-20364-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012600.1|sgd:S000003827|rcsb pdb:2KIT|reactome:R-SCE-1257604|reactome:R-SCE-3371571|reactome:R-SCE-389357|reactome:R-SCE-5218920|reactome:R-SCE-6804757|reactome:R-SCE-9639288|ensemblfungi:YJR066W(gene)|ensemblfungi:YJR066W_mRNA(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006413"(translational initiation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010008"(endosome membrane)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0031929"(TOR signaling)|go:"GO:0031930"(mitochondria-nucleus signaling pathway)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042790"(nucleolar large rRNA transcription by RNA polymerase I)|go:"GO:0044387"(negative regulation of protein kinase activity by regulation of protein phosphorylation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0090153"(regulation of sphingolipid biosynthetic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905356"(regulation of snRNA pseudouridine synthesis)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR024585|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|rcsb pdb:1W1N|rcsb pdb:2KIO|dip:DIP-917N|mint:P35169	refseq:NP_012056.1|sgd:S000001229|mint:P38873|dip:DIP-2639N|ensemblfungi:YHR186C(gene)|ensemblfungi:YHR186C_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|interpro:IPR000357(HEAT)|interpro:IPR001680(WD40 repeat)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|reactome:R-SCE-3371571|reactome:R-SCE-9639288	-	crc64:ACB1781B9963BB1E	crc64:B927EE93700176D3	figure legend:Fig. 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/09/03	2014/10/16	rogid:3aJf92VnNYbaZZj1+i3uk/IvNQI559292	rogid:8fDDVTuayLjREVAHrrpxJ9ExeCM559292	intact-crc:F63F017E663DE650|rigid:ymYNyaly20oBoRc+UYXDQYDatmo	false	myc tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P35169	uniprotkb:P41318	intact:EBI-19374|uniprotkb:D6VWN7|ensemblfungi:YJR066W	intact:EBI-28598|uniprotkb:D6W1H1|ensemblfungi:YNL006W	psi-mi:tor1_yeast(display_long)|uniprotkb:DRR1(gene name synonym)|uniprotkb:TOR1(gene name)|psi-mi:TOR1(display_short)|uniprotkb:YJR066W(locus name)|uniprotkb:J1803(orf name)|uniprotkb:Phosphatidylinositol kinase homolog TOR1(gene name synonym)|uniprotkb:Target of rapamycin kinase 1(gene name synonym)|uniprotkb:Dominant rapamycin resistance protein 1(gene name synonym)	psi-mi:lst8_yeast(display_long)|uniprotkb:Lethal with SEC13 protein 8(gene name synonym)|uniprotkb:YNL006W(locus name)|uniprotkb:N2005(orf name)|uniprotkb:LST8(gene name)|psi-mi:LST8(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Loewith et al. (2002)	pubmed:12408816|imex:IM-20364	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2434631|imex:IM-20364-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012600.1|sgd:S000003827|rcsb pdb:2KIT|reactome:R-SCE-1257604|reactome:R-SCE-3371571|reactome:R-SCE-389357|reactome:R-SCE-5218920|reactome:R-SCE-6804757|reactome:R-SCE-9639288|ensemblfungi:YJR066W(gene)|ensemblfungi:YJR066W_mRNA(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006413"(translational initiation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010008"(endosome membrane)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0031929"(TOR signaling)|go:"GO:0031930"(mitochondria-nucleus signaling pathway)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042790"(nucleolar large rRNA transcription by RNA polymerase I)|go:"GO:0044387"(negative regulation of protein kinase activity by regulation of protein phosphorylation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0090153"(regulation of sphingolipid biosynthetic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905356"(regulation of snRNA pseudouridine synthesis)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR024585|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|rcsb pdb:1W1N|rcsb pdb:2KIO|dip:DIP-917N|mint:P35169	reactome:R-SCE-3371571|sgd:S000004951|refseq:NP_014392.3|dip:DIP-5318N|reactome:R-SCE-1257604|reactome:R-SCE-389357|reactome:R-SCE-5218920|reactome:R-SCE-6804757|reactome:R-SCE-9639288|ensemblfungi:YNL006W(gene)|ensemblfungi:YNL006W_mRNA(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0010008"(endosome membrane)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0031929"(TOR signaling)|go:"GO:0031930"(mitochondria-nucleus signaling pathway)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034399"(nuclear periphery)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR037588|rcsb pdb:6EMK	-	crc64:ACB1781B9963BB1E	crc64:536AA1DB8E8151F0	figure legend:Fig. 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/09/03	2014/10/16	rogid:3aJf92VnNYbaZZj1+i3uk/IvNQI559292	rogid:DJkTl61Tdn8EtP/6tE7UFerq8w0559292	intact-crc:F63F017E663DE650|rigid:ymYNyaly20oBoRc+UYXDQYDatmo	false	myc tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P32600	uniprotkb:P40061	intact:EBI-19385|uniprotkb:D6VX00|ensemblfungi:YKL203C	intact:EBI-22621|uniprotkb:D3DM00|ensemblfungi:YER093C	psi-mi:tor2_yeast(display_long)|uniprotkb:DRR2(gene name synonym)|uniprotkb:TSC14(gene name synonym)|uniprotkb:YKL203C(locus name)|uniprotkb:TOR2(gene name)|psi-mi:TOR2(display_short)|uniprotkb:Phosphatidylinositol 4-kinase TOR2(gene name synonym)|uniprotkb:Target of rapamycin kinase 2(gene name synonym)|uniprotkb:Dominant rapamycin resistance protein 2(gene name synonym)|uniprotkb:Temperature-sensitive CSG2 suppressor protein 14(gene name synonym)	psi-mi:tsc11_yeast(display_long)|uniprotkb:AVO3(gene name synonym)|uniprotkb:YER093C(locus name)|uniprotkb:TSC11(gene name)|psi-mi:TSC11(display_short)|uniprotkb:Adheres voraciously to TOR2 protein 3(gene name synonym)|uniprotkb:Temperature-sensitive CSG2 suppressor protein 11(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Loewith et al. (2002)	pubmed:12408816|imex:IM-20364	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2434639|imex:IM-20364-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012719.2|sgd:S000001686|ensemblfungi:YKL203C(gene)|ensemblfungi:YKL203C_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0004430"(1-phosphatidylinositol 4-kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|go:"GO:0005739"(mitochondrion)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007049"(cell cycle)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905356"(regulation of snRNA pseudouridine synthesis)|go:"GO:2001108"(positive regulation of Rho guanyl-nucleotide exchange factor activity)|interpro:IPR018936|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|rcsb pdb:6EMK|reactome:R-SCE-1257604|reactome:R-SCE-3371571|reactome:R-SCE-389357|reactome:R-SCE-5218920|reactome:R-SCE-6804757|reactome:R-SCE-9639288|interpro:IPR024585|dip:DIP-2332N|mint:P32600	refseq:NP_011018.1|sgd:S000000895|dip:DIP-4957N|mint:P40061|ensemblfungi:YER093C(gene)|ensemblfungi:YER093C_mRNA(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0031929"(TOR signaling)|go:"GO:0031932"(TORC2 complex)|go:"GO:0038203"(TORC2 signaling)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028267|interpro:IPR028268|interpro:IPR029451|interpro:IPR029452|interpro:IPR029453|reactome:R-SCE-1257604|reactome:R-SCE-389357|reactome:R-SCE-5218920|reactome:R-SCE-6804757	-	crc64:F2349690146058CF	crc64:07BB5D75BA204E50	figure legend:Figure 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/09/03	2014/10/16	rogid:7IgrRILayw94y5+JjCP2x5VLJ4g559292	rogid:VWXhP0KgrXl8YKFmjxSKYVJbMcQ559292	intact-crc:B68105CFBD01D716|rigid:AVvjIdYtVzHppK2HlW0h4jbAxno	false	ha tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P32600	uniprotkb:Q08236	intact:EBI-19385|uniprotkb:D6VX00|ensemblfungi:YKL203C	intact:EBI-29284|uniprotkb:D6W1Y9|ensemblfungi:YOL078W	psi-mi:tor2_yeast(display_long)|uniprotkb:DRR2(gene name synonym)|uniprotkb:TSC14(gene name synonym)|uniprotkb:YKL203C(locus name)|uniprotkb:TOR2(gene name)|psi-mi:TOR2(display_short)|uniprotkb:Phosphatidylinositol 4-kinase TOR2(gene name synonym)|uniprotkb:Target of rapamycin kinase 2(gene name synonym)|uniprotkb:Dominant rapamycin resistance protein 2(gene name synonym)|uniprotkb:Temperature-sensitive CSG2 suppressor protein 14(gene name synonym)	psi-mi:avo1_yeast(display_long)|uniprotkb:Adheres voraciously to TOR2 protein 1(gene name synonym)|uniprotkb:YOL078W(locus name)|uniprotkb:AVO1(gene name)|psi-mi:AVO1(display_short)|uniprotkb:O1110(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Loewith et al. (2002)	pubmed:12408816|imex:IM-20364	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2434639|imex:IM-20364-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012719.2|sgd:S000001686|ensemblfungi:YKL203C(gene)|ensemblfungi:YKL203C_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0004430"(1-phosphatidylinositol 4-kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|go:"GO:0005739"(mitochondrion)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007049"(cell cycle)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905356"(regulation of snRNA pseudouridine synthesis)|go:"GO:2001108"(positive regulation of Rho guanyl-nucleotide exchange factor activity)|interpro:IPR018936|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|rcsb pdb:6EMK|reactome:R-SCE-1257604|reactome:R-SCE-3371571|reactome:R-SCE-389357|reactome:R-SCE-5218920|reactome:R-SCE-6804757|reactome:R-SCE-9639288|interpro:IPR024585|dip:DIP-2332N|mint:P32600	refseq:NP_014563.1|sgd:S000005438|dip:DIP-6357N|reactome:R-SCE-1257604|reactome:R-SCE-389357|reactome:R-SCE-5218920|reactome:R-SCE-6804757|ensemblfungi:YOL078W(gene)|ensemblfungi:YOL078W_mRNA(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0031929"(TOR signaling)|go:"GO:0031932"(TORC2 complex)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|interpro:IPR008828(Stress-activated map kinase interacting 1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR031313|interpro:IPR031567|rcsb pdb:3ULB|rcsb pdb:3ULC|rcsb pdb:6EMK	-	crc64:F2349690146058CF	crc64:ED2B30D014EE5652	figure legend:Figure 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/09/03	2014/10/16	rogid:7IgrRILayw94y5+JjCP2x5VLJ4g559292	rogid:TzyrCBNOWYLrFV9+MUOnWXXvJYs559292	intact-crc:B68105CFBD01D716|rigid:AVvjIdYtVzHppK2HlW0h4jbAxno	false	ha tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P32600	uniprotkb:Q04749	intact:EBI-19385|uniprotkb:D6VX00|ensemblfungi:YKL203C	intact:EBI-28131|uniprotkb:D6VZP2|ensemblfungi:YMR068W	psi-mi:tor2_yeast(display_long)|uniprotkb:DRR2(gene name synonym)|uniprotkb:TSC14(gene name synonym)|uniprotkb:YKL203C(locus name)|uniprotkb:TOR2(gene name)|psi-mi:TOR2(display_short)|uniprotkb:Phosphatidylinositol 4-kinase TOR2(gene name synonym)|uniprotkb:Target of rapamycin kinase 2(gene name synonym)|uniprotkb:Dominant rapamycin resistance protein 2(gene name synonym)|uniprotkb:Temperature-sensitive CSG2 suppressor protein 14(gene name synonym)	psi-mi:avo2_yeast(display_long)|uniprotkb:YMR068W(locus name)|uniprotkb:YM9916.07(orf name)|uniprotkb:AVO2(gene name)|psi-mi:AVO2(display_short)|uniprotkb:Adheres voraciously to TOR2 protein 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Loewith et al. (2002)	pubmed:12408816|imex:IM-20364	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2434639|imex:IM-20364-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012719.2|sgd:S000001686|ensemblfungi:YKL203C(gene)|ensemblfungi:YKL203C_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0004430"(1-phosphatidylinositol 4-kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|go:"GO:0005739"(mitochondrion)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007049"(cell cycle)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905356"(regulation of snRNA pseudouridine synthesis)|go:"GO:2001108"(positive regulation of Rho guanyl-nucleotide exchange factor activity)|interpro:IPR018936|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|rcsb pdb:6EMK|reactome:R-SCE-1257604|reactome:R-SCE-3371571|reactome:R-SCE-389357|reactome:R-SCE-5218920|reactome:R-SCE-6804757|reactome:R-SCE-9639288|interpro:IPR024585|dip:DIP-2332N|mint:P32600	refseq:NP_013784.1|sgd:S000004672|dip:DIP-1958N|mint:Q04749|ensemblfungi:YMR068W(gene)|ensemblfungi:YMR068W_mRNA(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031929"(TOR signaling)|go:"GO:0031932"(TORC2 complex)|interpro:IPR002110(Ankyrin)|interpro:IPR036770|rcsb pdb:6EMK	-	crc64:F2349690146058CF	-	figure legend:Figure 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/09/03	2014/10/16	rogid:7IgrRILayw94y5+JjCP2x5VLJ4g559292	rogid:T4jLsFiHINxRGduuu5DmqEPF3EE559292	intact-crc:B68105CFBD01D716|rigid:AVvjIdYtVzHppK2HlW0h4jbAxno	false	ha tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P32600	uniprotkb:P41318	intact:EBI-19385|uniprotkb:D6VX00|ensemblfungi:YKL203C	intact:EBI-28598|uniprotkb:D6W1H1|ensemblfungi:YNL006W	psi-mi:tor2_yeast(display_long)|uniprotkb:DRR2(gene name synonym)|uniprotkb:TSC14(gene name synonym)|uniprotkb:YKL203C(locus name)|uniprotkb:TOR2(gene name)|psi-mi:TOR2(display_short)|uniprotkb:Phosphatidylinositol 4-kinase TOR2(gene name synonym)|uniprotkb:Target of rapamycin kinase 2(gene name synonym)|uniprotkb:Dominant rapamycin resistance protein 2(gene name synonym)|uniprotkb:Temperature-sensitive CSG2 suppressor protein 14(gene name synonym)	psi-mi:lst8_yeast(display_long)|uniprotkb:Lethal with SEC13 protein 8(gene name synonym)|uniprotkb:YNL006W(locus name)|uniprotkb:N2005(orf name)|uniprotkb:LST8(gene name)|psi-mi:LST8(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Loewith et al. (2002)	pubmed:12408816|imex:IM-20364	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2434639|imex:IM-20364-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012719.2|sgd:S000001686|ensemblfungi:YKL203C(gene)|ensemblfungi:YKL203C_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0004430"(1-phosphatidylinositol 4-kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|go:"GO:0005739"(mitochondrion)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007049"(cell cycle)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905356"(regulation of snRNA pseudouridine synthesis)|go:"GO:2001108"(positive regulation of Rho guanyl-nucleotide exchange factor activity)|interpro:IPR018936|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|rcsb pdb:6EMK|reactome:R-SCE-1257604|reactome:R-SCE-3371571|reactome:R-SCE-389357|reactome:R-SCE-5218920|reactome:R-SCE-6804757|reactome:R-SCE-9639288|interpro:IPR024585|dip:DIP-2332N|mint:P32600	reactome:R-SCE-3371571|sgd:S000004951|refseq:NP_014392.3|dip:DIP-5318N|reactome:R-SCE-1257604|reactome:R-SCE-389357|reactome:R-SCE-5218920|reactome:R-SCE-6804757|reactome:R-SCE-9639288|ensemblfungi:YNL006W(gene)|ensemblfungi:YNL006W_mRNA(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0010008"(endosome membrane)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0031929"(TOR signaling)|go:"GO:0031930"(mitochondria-nucleus signaling pathway)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034399"(nuclear periphery)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR037588|rcsb pdb:6EMK	-	crc64:F2349690146058CF	crc64:536AA1DB8E8151F0	figure legend:Figure 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/09/03	2014/10/16	rogid:7IgrRILayw94y5+JjCP2x5VLJ4g559292	rogid:DJkTl61Tdn8EtP/6tE7UFerq8w0559292	intact-crc:B68105CFBD01D716|rigid:AVvjIdYtVzHppK2HlW0h4jbAxno	false	ha tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P20081	uniprotkb:P32600	intact:EBI-6961|uniprotkb:D6W147|ensemblfungi:YNL135C	intact:EBI-19385|uniprotkb:D6VX00|ensemblfungi:YKL203C	psi-mi:fkbp_yeast(display_long)|uniprotkb:RBP1(gene name synonym)|uniprotkb:N1213(orf name)|uniprotkb:N1845(orf name)|uniprotkb:YNL135C(locus name)|uniprotkb:FPR1(gene name)|psi-mi:FPR1(display_short)|uniprotkb:FKB1(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase(gene name synonym)|uniprotkb:Rapamycin-binding protein(gene name synonym)	psi-mi:tor2_yeast(display_long)|uniprotkb:DRR2(gene name synonym)|uniprotkb:TSC14(gene name synonym)|uniprotkb:YKL203C(locus name)|uniprotkb:TOR2(gene name)|psi-mi:TOR2(display_short)|uniprotkb:Phosphatidylinositol 4-kinase TOR2(gene name synonym)|uniprotkb:Target of rapamycin kinase 2(gene name synonym)|uniprotkb:Dominant rapamycin resistance protein 2(gene name synonym)|uniprotkb:Temperature-sensitive CSG2 suppressor protein 14(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Loewith et al. (2002)	pubmed:12408816|imex:IM-20364	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2434851|imex:IM-20364-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014264.1|sgd:S000005079|dip:DIP-1263N|mint:P20081|ensemblfungi:YNL135C(gene)|ensemblfungi:YNL135C_mRNA(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005527"(macrolide binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006325"(chromatin organization)|go:"GO:0006457"(protein folding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:1901710"(regulation of homoserine biosynthetic process)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|rcsb pdb:1YAT	refseq:NP_012719.2|sgd:S000001686|ensemblfungi:YKL203C(gene)|ensemblfungi:YKL203C_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0004430"(1-phosphatidylinositol 4-kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|go:"GO:0005739"(mitochondrion)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007049"(cell cycle)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905356"(regulation of snRNA pseudouridine synthesis)|go:"GO:2001108"(positive regulation of Rho guanyl-nucleotide exchange factor activity)|interpro:IPR018936|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|rcsb pdb:6EMK|reactome:R-SCE-1257604|reactome:R-SCE-3371571|reactome:R-SCE-389357|reactome:R-SCE-5218920|reactome:R-SCE-6804757|reactome:R-SCE-9639288|interpro:IPR024585|dip:DIP-2332N|mint:P32600	-	crc64:65C134830D300C06	crc64:F2349690146058CF	figure legend:Fig. 4|agonist:Rapamycin|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/09/03	2014/10/16	rogid:8afvGSk+mPghtqkVoWd2rHJXXhQ559292	rogid:7IgrRILayw94y5+JjCP2x5VLJ4g559292	intact-crc:2BCE4CBE8459EEE3|rigid:OtC+YOD0sh3VCjrG18ejcy8MZko	false	calmodulin binding peptide plus protein a tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P20081	uniprotkb:P38873	intact:EBI-6961|uniprotkb:D6W147|ensemblfungi:YNL135C	intact:EBI-24864|uniprotkb:D3DLD4|ensemblfungi:YHR186C	psi-mi:fkbp_yeast(display_long)|uniprotkb:RBP1(gene name synonym)|uniprotkb:N1213(orf name)|uniprotkb:N1845(orf name)|uniprotkb:YNL135C(locus name)|uniprotkb:FPR1(gene name)|psi-mi:FPR1(display_short)|uniprotkb:FKB1(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase(gene name synonym)|uniprotkb:Rapamycin-binding protein(gene name synonym)	psi-mi:kog1_yeast(display_long)|uniprotkb:Kontroller of growth protein 1(gene name synonym)|uniprotkb:Local anesthetic-sensitive protein 24(gene name synonym)|uniprotkb:YHR186C(locus name)|uniprotkb:KOG1(gene name)|psi-mi:KOG1(display_short)|uniprotkb:LAS24(gene name synonym)|uniprotkb:H9998.14(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Loewith et al. (2002)	pubmed:12408816|imex:IM-20364	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2434851|imex:IM-20364-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014264.1|sgd:S000005079|dip:DIP-1263N|mint:P20081|ensemblfungi:YNL135C(gene)|ensemblfungi:YNL135C_mRNA(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005527"(macrolide binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006325"(chromatin organization)|go:"GO:0006457"(protein folding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:1901710"(regulation of homoserine biosynthetic process)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|rcsb pdb:1YAT	refseq:NP_012056.1|sgd:S000001229|mint:P38873|dip:DIP-2639N|ensemblfungi:YHR186C(gene)|ensemblfungi:YHR186C_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|interpro:IPR000357(HEAT)|interpro:IPR001680(WD40 repeat)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|reactome:R-SCE-3371571|reactome:R-SCE-9639288	-	crc64:65C134830D300C06	crc64:B927EE93700176D3	figure legend:Fig. 4|agonist:Rapamycin|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/09/03	2014/10/16	rogid:8afvGSk+mPghtqkVoWd2rHJXXhQ559292	rogid:8fDDVTuayLjREVAHrrpxJ9ExeCM559292	intact-crc:2BCE4CBE8459EEE3|rigid:OtC+YOD0sh3VCjrG18ejcy8MZko	false	calmodulin binding peptide plus protein a tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P20081	uniprotkb:P35169	intact:EBI-6961|uniprotkb:D6W147|ensemblfungi:YNL135C	intact:EBI-19374|uniprotkb:D6VWN7|ensemblfungi:YJR066W	psi-mi:fkbp_yeast(display_long)|uniprotkb:RBP1(gene name synonym)|uniprotkb:N1213(orf name)|uniprotkb:N1845(orf name)|uniprotkb:YNL135C(locus name)|uniprotkb:FPR1(gene name)|psi-mi:FPR1(display_short)|uniprotkb:FKB1(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase(gene name synonym)|uniprotkb:Rapamycin-binding protein(gene name synonym)	psi-mi:tor1_yeast(display_long)|uniprotkb:DRR1(gene name synonym)|uniprotkb:TOR1(gene name)|psi-mi:TOR1(display_short)|uniprotkb:YJR066W(locus name)|uniprotkb:J1803(orf name)|uniprotkb:Phosphatidylinositol kinase homolog TOR1(gene name synonym)|uniprotkb:Target of rapamycin kinase 1(gene name synonym)|uniprotkb:Dominant rapamycin resistance protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Loewith et al. (2002)	pubmed:12408816|imex:IM-20364	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2434851|imex:IM-20364-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014264.1|sgd:S000005079|dip:DIP-1263N|mint:P20081|ensemblfungi:YNL135C(gene)|ensemblfungi:YNL135C_mRNA(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005527"(macrolide binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006325"(chromatin organization)|go:"GO:0006457"(protein folding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:1901710"(regulation of homoserine biosynthetic process)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|rcsb pdb:1YAT	refseq:NP_012600.1|sgd:S000003827|rcsb pdb:2KIT|reactome:R-SCE-1257604|reactome:R-SCE-3371571|reactome:R-SCE-389357|reactome:R-SCE-5218920|reactome:R-SCE-6804757|reactome:R-SCE-9639288|ensemblfungi:YJR066W(gene)|ensemblfungi:YJR066W_mRNA(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006413"(translational initiation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010008"(endosome membrane)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0031929"(TOR signaling)|go:"GO:0031930"(mitochondria-nucleus signaling pathway)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042790"(nucleolar large rRNA transcription by RNA polymerase I)|go:"GO:0044387"(negative regulation of protein kinase activity by regulation of protein phosphorylation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0090153"(regulation of sphingolipid biosynthetic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905356"(regulation of snRNA pseudouridine synthesis)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR024585|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|rcsb pdb:1W1N|rcsb pdb:2KIO|dip:DIP-917N|mint:P35169	-	crc64:65C134830D300C06	crc64:ACB1781B9963BB1E	figure legend:Fig. 4|agonist:Rapamycin|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/09/03	2014/10/16	rogid:8afvGSk+mPghtqkVoWd2rHJXXhQ559292	rogid:3aJf92VnNYbaZZj1+i3uk/IvNQI559292	intact-crc:2BCE4CBE8459EEE3|rigid:OtC+YOD0sh3VCjrG18ejcy8MZko	false	calmodulin binding peptide plus protein a tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P20081	uniprotkb:P41318	intact:EBI-6961|uniprotkb:D6W147|ensemblfungi:YNL135C	intact:EBI-28598|uniprotkb:D6W1H1|ensemblfungi:YNL006W	psi-mi:fkbp_yeast(display_long)|uniprotkb:RBP1(gene name synonym)|uniprotkb:N1213(orf name)|uniprotkb:N1845(orf name)|uniprotkb:YNL135C(locus name)|uniprotkb:FPR1(gene name)|psi-mi:FPR1(display_short)|uniprotkb:FKB1(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase(gene name synonym)|uniprotkb:Rapamycin-binding protein(gene name synonym)	psi-mi:lst8_yeast(display_long)|uniprotkb:Lethal with SEC13 protein 8(gene name synonym)|uniprotkb:YNL006W(locus name)|uniprotkb:N2005(orf name)|uniprotkb:LST8(gene name)|psi-mi:LST8(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Loewith et al. (2002)	pubmed:12408816|imex:IM-20364	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2434851|imex:IM-20364-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014264.1|sgd:S000005079|dip:DIP-1263N|mint:P20081|ensemblfungi:YNL135C(gene)|ensemblfungi:YNL135C_mRNA(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005527"(macrolide binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006325"(chromatin organization)|go:"GO:0006457"(protein folding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:1901710"(regulation of homoserine biosynthetic process)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|rcsb pdb:1YAT	reactome:R-SCE-3371571|sgd:S000004951|refseq:NP_014392.3|dip:DIP-5318N|reactome:R-SCE-1257604|reactome:R-SCE-389357|reactome:R-SCE-5218920|reactome:R-SCE-6804757|reactome:R-SCE-9639288|ensemblfungi:YNL006W(gene)|ensemblfungi:YNL006W_mRNA(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0010008"(endosome membrane)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0031929"(TOR signaling)|go:"GO:0031930"(mitochondria-nucleus signaling pathway)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034399"(nuclear periphery)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR037588|rcsb pdb:6EMK	-	crc64:65C134830D300C06	crc64:536AA1DB8E8151F0	figure legend:Fig. 4|agonist:Rapamycin|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/09/03	2014/10/16	rogid:8afvGSk+mPghtqkVoWd2rHJXXhQ559292	rogid:DJkTl61Tdn8EtP/6tE7UFerq8w0559292	intact-crc:2BCE4CBE8459EEE3|rigid:OtC+YOD0sh3VCjrG18ejcy8MZko	false	calmodulin binding peptide plus protein a tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P41318	uniprotkb:P35169	intact:EBI-28598|uniprotkb:D6W1H1|ensemblfungi:YNL006W	intact:EBI-19374|uniprotkb:D6VWN7|ensemblfungi:YJR066W	psi-mi:lst8_yeast(display_long)|uniprotkb:Lethal with SEC13 protein 8(gene name synonym)|uniprotkb:YNL006W(locus name)|uniprotkb:N2005(orf name)|uniprotkb:LST8(gene name)|psi-mi:LST8(display_short)	psi-mi:tor1_yeast(display_long)|uniprotkb:DRR1(gene name synonym)|uniprotkb:TOR1(gene name)|psi-mi:TOR1(display_short)|uniprotkb:YJR066W(locus name)|uniprotkb:J1803(orf name)|uniprotkb:Phosphatidylinositol kinase homolog TOR1(gene name synonym)|uniprotkb:Target of rapamycin kinase 1(gene name synonym)|uniprotkb:Dominant rapamycin resistance protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Loewith et al. (2002)	pubmed:12408816|imex:IM-20364	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2434672|imex:IM-20364-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-SCE-3371571|sgd:S000004951|refseq:NP_014392.3|dip:DIP-5318N|reactome:R-SCE-1257604|reactome:R-SCE-389357|reactome:R-SCE-5218920|reactome:R-SCE-6804757|reactome:R-SCE-9639288|ensemblfungi:YNL006W(gene)|ensemblfungi:YNL006W_mRNA(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0010008"(endosome membrane)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0031929"(TOR signaling)|go:"GO:0031930"(mitochondria-nucleus signaling pathway)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034399"(nuclear periphery)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR037588|rcsb pdb:6EMK	refseq:NP_012600.1|sgd:S000003827|rcsb pdb:2KIT|reactome:R-SCE-1257604|reactome:R-SCE-3371571|reactome:R-SCE-389357|reactome:R-SCE-5218920|reactome:R-SCE-6804757|reactome:R-SCE-9639288|ensemblfungi:YJR066W(gene)|ensemblfungi:YJR066W_mRNA(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006413"(translational initiation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010008"(endosome membrane)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0031929"(TOR signaling)|go:"GO:0031930"(mitochondria-nucleus signaling pathway)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042790"(nucleolar large rRNA transcription by RNA polymerase I)|go:"GO:0044387"(negative regulation of protein kinase activity by regulation of protein phosphorylation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0090153"(regulation of sphingolipid biosynthetic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905356"(regulation of snRNA pseudouridine synthesis)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR024585|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|rcsb pdb:1W1N|rcsb pdb:2KIO|dip:DIP-917N|mint:P35169	-	crc64:536AA1DB8E8151F0	crc64:ACB1781B9963BB1E	figure legend:Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/09/03	2014/10/16	rogid:DJkTl61Tdn8EtP/6tE7UFerq8w0559292	rogid:3aJf92VnNYbaZZj1+i3uk/IvNQI559292	intact-crc:B0E65BAC9EB84B31|rigid:ZcoHYs163exPAHO33nRdvJpFgXE	false	ha tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P41318	uniprotkb:P32600	intact:EBI-28598|uniprotkb:D6W1H1|ensemblfungi:YNL006W	intact:EBI-19385|uniprotkb:D6VX00|ensemblfungi:YKL203C	psi-mi:lst8_yeast(display_long)|uniprotkb:Lethal with SEC13 protein 8(gene name synonym)|uniprotkb:YNL006W(locus name)|uniprotkb:N2005(orf name)|uniprotkb:LST8(gene name)|psi-mi:LST8(display_short)	psi-mi:tor2_yeast(display_long)|uniprotkb:DRR2(gene name synonym)|uniprotkb:TSC14(gene name synonym)|uniprotkb:YKL203C(locus name)|uniprotkb:TOR2(gene name)|psi-mi:TOR2(display_short)|uniprotkb:Phosphatidylinositol 4-kinase TOR2(gene name synonym)|uniprotkb:Target of rapamycin kinase 2(gene name synonym)|uniprotkb:Dominant rapamycin resistance protein 2(gene name synonym)|uniprotkb:Temperature-sensitive CSG2 suppressor protein 14(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Loewith et al. (2002)	pubmed:12408816|imex:IM-20364	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2434684|imex:IM-20364-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-SCE-3371571|sgd:S000004951|refseq:NP_014392.3|dip:DIP-5318N|reactome:R-SCE-1257604|reactome:R-SCE-389357|reactome:R-SCE-5218920|reactome:R-SCE-6804757|reactome:R-SCE-9639288|ensemblfungi:YNL006W(gene)|ensemblfungi:YNL006W_mRNA(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0010008"(endosome membrane)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0031929"(TOR signaling)|go:"GO:0031930"(mitochondria-nucleus signaling pathway)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034399"(nuclear periphery)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR037588|rcsb pdb:6EMK	refseq:NP_012719.2|sgd:S000001686|ensemblfungi:YKL203C(gene)|ensemblfungi:YKL203C_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0004430"(1-phosphatidylinositol 4-kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|go:"GO:0005739"(mitochondrion)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007049"(cell cycle)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905356"(regulation of snRNA pseudouridine synthesis)|go:"GO:2001108"(positive regulation of Rho guanyl-nucleotide exchange factor activity)|interpro:IPR018936|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|rcsb pdb:6EMK|reactome:R-SCE-1257604|reactome:R-SCE-3371571|reactome:R-SCE-389357|reactome:R-SCE-5218920|reactome:R-SCE-6804757|reactome:R-SCE-9639288|interpro:IPR024585|dip:DIP-2332N|mint:P32600	-	crc64:536AA1DB8E8151F0	crc64:F2349690146058CF	figure legend:Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/09/03	2014/10/16	rogid:DJkTl61Tdn8EtP/6tE7UFerq8w0559292	rogid:7IgrRILayw94y5+JjCP2x5VLJ4g559292	intact-crc:6BD3F83B7D389F3E|rigid:z6CBH/8LaHSNui4f0sf5AtjoYyM	false	myc tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P38873	uniprotkb:P32600	intact:EBI-24864|uniprotkb:D3DLD4|ensemblfungi:YHR186C	intact:EBI-19385|uniprotkb:D6VX00|ensemblfungi:YKL203C	psi-mi:kog1_yeast(display_long)|uniprotkb:Kontroller of growth protein 1(gene name synonym)|uniprotkb:Local anesthetic-sensitive protein 24(gene name synonym)|uniprotkb:YHR186C(locus name)|uniprotkb:KOG1(gene name)|psi-mi:KOG1(display_short)|uniprotkb:LAS24(gene name synonym)|uniprotkb:H9998.14(orf name)	psi-mi:tor2_yeast(display_long)|uniprotkb:DRR2(gene name synonym)|uniprotkb:TSC14(gene name synonym)|uniprotkb:YKL203C(locus name)|uniprotkb:TOR2(gene name)|psi-mi:TOR2(display_short)|uniprotkb:Phosphatidylinositol 4-kinase TOR2(gene name synonym)|uniprotkb:Target of rapamycin kinase 2(gene name synonym)|uniprotkb:Dominant rapamycin resistance protein 2(gene name synonym)|uniprotkb:Temperature-sensitive CSG2 suppressor protein 14(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Loewith et al. (2002)	pubmed:12408816|imex:IM-20364	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2434705|imex:IM-20364-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012056.1|sgd:S000001229|mint:P38873|dip:DIP-2639N|ensemblfungi:YHR186C(gene)|ensemblfungi:YHR186C_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|interpro:IPR000357(HEAT)|interpro:IPR001680(WD40 repeat)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|reactome:R-SCE-3371571|reactome:R-SCE-9639288	refseq:NP_012719.2|sgd:S000001686|ensemblfungi:YKL203C(gene)|ensemblfungi:YKL203C_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0004430"(1-phosphatidylinositol 4-kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|go:"GO:0005739"(mitochondrion)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007049"(cell cycle)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905356"(regulation of snRNA pseudouridine synthesis)|go:"GO:2001108"(positive regulation of Rho guanyl-nucleotide exchange factor activity)|interpro:IPR018936|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|rcsb pdb:6EMK|reactome:R-SCE-1257604|reactome:R-SCE-3371571|reactome:R-SCE-389357|reactome:R-SCE-5218920|reactome:R-SCE-6804757|reactome:R-SCE-9639288|interpro:IPR024585|dip:DIP-2332N|mint:P32600	-	crc64:B927EE93700176D3	crc64:F2349690146058CF	figure legend:Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/09/03	2014/10/16	rogid:8fDDVTuayLjREVAHrrpxJ9ExeCM559292	rogid:7IgrRILayw94y5+JjCP2x5VLJ4g559292	intact-crc:E4164DE38B5621B7|rigid:JFhszlHU8upnnV0rPdJq+rqJINk	false	myc tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P32600	uniprotkb:Q08236	intact:EBI-19385|uniprotkb:D6VX00|ensemblfungi:YKL203C	intact:EBI-29284|uniprotkb:D6W1Y9|ensemblfungi:YOL078W	psi-mi:tor2_yeast(display_long)|uniprotkb:DRR2(gene name synonym)|uniprotkb:TSC14(gene name synonym)|uniprotkb:YKL203C(locus name)|uniprotkb:TOR2(gene name)|psi-mi:TOR2(display_short)|uniprotkb:Phosphatidylinositol 4-kinase TOR2(gene name synonym)|uniprotkb:Target of rapamycin kinase 2(gene name synonym)|uniprotkb:Dominant rapamycin resistance protein 2(gene name synonym)|uniprotkb:Temperature-sensitive CSG2 suppressor protein 14(gene name synonym)	psi-mi:avo1_yeast(display_long)|uniprotkb:Adheres voraciously to TOR2 protein 1(gene name synonym)|uniprotkb:YOL078W(locus name)|uniprotkb:AVO1(gene name)|psi-mi:AVO1(display_short)|uniprotkb:O1110(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Loewith et al. (2002)	pubmed:12408816|imex:IM-20364	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2434714|imex:IM-20364-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012719.2|sgd:S000001686|ensemblfungi:YKL203C(gene)|ensemblfungi:YKL203C_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0004430"(1-phosphatidylinositol 4-kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|go:"GO:0005739"(mitochondrion)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007049"(cell cycle)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905356"(regulation of snRNA pseudouridine synthesis)|go:"GO:2001108"(positive regulation of Rho guanyl-nucleotide exchange factor activity)|interpro:IPR018936|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|rcsb pdb:6EMK|reactome:R-SCE-1257604|reactome:R-SCE-3371571|reactome:R-SCE-389357|reactome:R-SCE-5218920|reactome:R-SCE-6804757|reactome:R-SCE-9639288|interpro:IPR024585|dip:DIP-2332N|mint:P32600	refseq:NP_014563.1|sgd:S000005438|dip:DIP-6357N|reactome:R-SCE-1257604|reactome:R-SCE-389357|reactome:R-SCE-5218920|reactome:R-SCE-6804757|ensemblfungi:YOL078W(gene)|ensemblfungi:YOL078W_mRNA(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0031929"(TOR signaling)|go:"GO:0031932"(TORC2 complex)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|interpro:IPR008828(Stress-activated map kinase interacting 1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR031313|interpro:IPR031567|rcsb pdb:3ULB|rcsb pdb:3ULC|rcsb pdb:6EMK	-	crc64:F2349690146058CF	crc64:ED2B30D014EE5652	figure legend:Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/09/03	2014/10/16	rogid:7IgrRILayw94y5+JjCP2x5VLJ4g559292	rogid:TzyrCBNOWYLrFV9+MUOnWXXvJYs559292	intact-crc:26BC6D81FCB5D5F2|rigid:AuFHwDc117prnZmamptS8NYnLBY	false	ha tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q04749	uniprotkb:P32600	intact:EBI-28131|uniprotkb:D6VZP2|ensemblfungi:YMR068W	intact:EBI-19385|uniprotkb:D6VX00|ensemblfungi:YKL203C	psi-mi:avo2_yeast(display_long)|uniprotkb:YMR068W(locus name)|uniprotkb:YM9916.07(orf name)|uniprotkb:AVO2(gene name)|psi-mi:AVO2(display_short)|uniprotkb:Adheres voraciously to TOR2 protein 2(gene name synonym)	psi-mi:tor2_yeast(display_long)|uniprotkb:DRR2(gene name synonym)|uniprotkb:TSC14(gene name synonym)|uniprotkb:YKL203C(locus name)|uniprotkb:TOR2(gene name)|psi-mi:TOR2(display_short)|uniprotkb:Phosphatidylinositol 4-kinase TOR2(gene name synonym)|uniprotkb:Target of rapamycin kinase 2(gene name synonym)|uniprotkb:Dominant rapamycin resistance protein 2(gene name synonym)|uniprotkb:Temperature-sensitive CSG2 suppressor protein 14(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Loewith et al. (2002)	pubmed:12408816|imex:IM-20364	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2434723|imex:IM-20364-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013784.1|sgd:S000004672|dip:DIP-1958N|mint:Q04749|ensemblfungi:YMR068W(gene)|ensemblfungi:YMR068W_mRNA(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031929"(TOR signaling)|go:"GO:0031932"(TORC2 complex)|interpro:IPR002110(Ankyrin)|interpro:IPR036770|rcsb pdb:6EMK	refseq:NP_012719.2|sgd:S000001686|ensemblfungi:YKL203C(gene)|ensemblfungi:YKL203C_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0004430"(1-phosphatidylinositol 4-kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|go:"GO:0005739"(mitochondrion)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007049"(cell cycle)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905356"(regulation of snRNA pseudouridine synthesis)|go:"GO:2001108"(positive regulation of Rho guanyl-nucleotide exchange factor activity)|interpro:IPR018936|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|rcsb pdb:6EMK|reactome:R-SCE-1257604|reactome:R-SCE-3371571|reactome:R-SCE-389357|reactome:R-SCE-5218920|reactome:R-SCE-6804757|reactome:R-SCE-9639288|interpro:IPR024585|dip:DIP-2332N|mint:P32600	-	-	crc64:F2349690146058CF	figure legend:Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/09/03	2014/10/16	rogid:T4jLsFiHINxRGduuu5DmqEPF3EE559292	rogid:7IgrRILayw94y5+JjCP2x5VLJ4g559292	intact-crc:73235E74D7E5CF1D|rigid:HOUooZ/+XQXNzqcKceYlYWa9yAE	false	myc tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P40061	uniprotkb:P32600	intact:EBI-22621|uniprotkb:D3DM00|ensemblfungi:YER093C	intact:EBI-19385|uniprotkb:D6VX00|ensemblfungi:YKL203C	psi-mi:tsc11_yeast(display_long)|uniprotkb:AVO3(gene name synonym)|uniprotkb:YER093C(locus name)|uniprotkb:TSC11(gene name)|psi-mi:TSC11(display_short)|uniprotkb:Adheres voraciously to TOR2 protein 3(gene name synonym)|uniprotkb:Temperature-sensitive CSG2 suppressor protein 11(gene name synonym)	psi-mi:tor2_yeast(display_long)|uniprotkb:DRR2(gene name synonym)|uniprotkb:TSC14(gene name synonym)|uniprotkb:YKL203C(locus name)|uniprotkb:TOR2(gene name)|psi-mi:TOR2(display_short)|uniprotkb:Phosphatidylinositol 4-kinase TOR2(gene name synonym)|uniprotkb:Target of rapamycin kinase 2(gene name synonym)|uniprotkb:Dominant rapamycin resistance protein 2(gene name synonym)|uniprotkb:Temperature-sensitive CSG2 suppressor protein 14(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Loewith et al. (2002)	pubmed:12408816|imex:IM-20364	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2434732|imex:IM-20364-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011018.1|sgd:S000000895|dip:DIP-4957N|mint:P40061|ensemblfungi:YER093C(gene)|ensemblfungi:YER093C_mRNA(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0031929"(TOR signaling)|go:"GO:0031932"(TORC2 complex)|go:"GO:0038203"(TORC2 signaling)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028267|interpro:IPR028268|interpro:IPR029451|interpro:IPR029452|interpro:IPR029453|reactome:R-SCE-1257604|reactome:R-SCE-389357|reactome:R-SCE-5218920|reactome:R-SCE-6804757	refseq:NP_012719.2|sgd:S000001686|ensemblfungi:YKL203C(gene)|ensemblfungi:YKL203C_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0004430"(1-phosphatidylinositol 4-kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|go:"GO:0005739"(mitochondrion)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007049"(cell cycle)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905356"(regulation of snRNA pseudouridine synthesis)|go:"GO:2001108"(positive regulation of Rho guanyl-nucleotide exchange factor activity)|interpro:IPR018936|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|rcsb pdb:6EMK|reactome:R-SCE-1257604|reactome:R-SCE-3371571|reactome:R-SCE-389357|reactome:R-SCE-5218920|reactome:R-SCE-6804757|reactome:R-SCE-9639288|interpro:IPR024585|dip:DIP-2332N|mint:P32600	-	crc64:07BB5D75BA204E50	crc64:F2349690146058CF	figure legend:Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/09/03	2014/10/16	rogid:VWXhP0KgrXl8YKFmjxSKYVJbMcQ559292	rogid:7IgrRILayw94y5+JjCP2x5VLJ4g559292	intact-crc:67BF68B5C0AA9E2A|rigid:riDa4caLpRerAlgFa+v2xhzKO18	false	myc tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P35169	uniprotkb:P38873	intact:EBI-19374|uniprotkb:D6VWN7|ensemblfungi:YJR066W	intact:EBI-24864|uniprotkb:D3DLD4|ensemblfungi:YHR186C	psi-mi:tor1_yeast(display_long)|uniprotkb:DRR1(gene name synonym)|uniprotkb:TOR1(gene name)|psi-mi:TOR1(display_short)|uniprotkb:YJR066W(locus name)|uniprotkb:J1803(orf name)|uniprotkb:Phosphatidylinositol kinase homolog TOR1(gene name synonym)|uniprotkb:Target of rapamycin kinase 1(gene name synonym)|uniprotkb:Dominant rapamycin resistance protein 1(gene name synonym)	psi-mi:kog1_yeast(display_long)|uniprotkb:Kontroller of growth protein 1(gene name synonym)|uniprotkb:Local anesthetic-sensitive protein 24(gene name synonym)|uniprotkb:YHR186C(locus name)|uniprotkb:KOG1(gene name)|psi-mi:KOG1(display_short)|uniprotkb:LAS24(gene name synonym)|uniprotkb:H9998.14(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Loewith et al. (2002)	pubmed:12408816|imex:IM-20364	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2434741|imex:IM-20364-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012600.1|sgd:S000003827|rcsb pdb:2KIT|reactome:R-SCE-1257604|reactome:R-SCE-3371571|reactome:R-SCE-389357|reactome:R-SCE-5218920|reactome:R-SCE-6804757|reactome:R-SCE-9639288|ensemblfungi:YJR066W(gene)|ensemblfungi:YJR066W_mRNA(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006413"(translational initiation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010008"(endosome membrane)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0031929"(TOR signaling)|go:"GO:0031930"(mitochondria-nucleus signaling pathway)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042790"(nucleolar large rRNA transcription by RNA polymerase I)|go:"GO:0044387"(negative regulation of protein kinase activity by regulation of protein phosphorylation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0090153"(regulation of sphingolipid biosynthetic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905356"(regulation of snRNA pseudouridine synthesis)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR024585|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|rcsb pdb:1W1N|rcsb pdb:2KIO|dip:DIP-917N|mint:P35169	refseq:NP_012056.1|sgd:S000001229|mint:P38873|dip:DIP-2639N|ensemblfungi:YHR186C(gene)|ensemblfungi:YHR186C_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|interpro:IPR000357(HEAT)|interpro:IPR001680(WD40 repeat)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|reactome:R-SCE-3371571|reactome:R-SCE-9639288	-	crc64:ACB1781B9963BB1E	crc64:B927EE93700176D3	figure legend:Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/09/03	2014/10/16	rogid:3aJf92VnNYbaZZj1+i3uk/IvNQI559292	rogid:8fDDVTuayLjREVAHrrpxJ9ExeCM559292	intact-crc:98FF440E251FC4D2|rigid:lZY0XGZN0kxdR6jsc4lV7pk2rUE	false	myc tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P32600	uniprotkb:P41318	intact:EBI-19385|uniprotkb:D6VX00|ensemblfungi:YKL203C	intact:EBI-28598|uniprotkb:D6W1H1|ensemblfungi:YNL006W	psi-mi:tor2_yeast(display_long)|uniprotkb:DRR2(gene name synonym)|uniprotkb:TSC14(gene name synonym)|uniprotkb:YKL203C(locus name)|uniprotkb:TOR2(gene name)|psi-mi:TOR2(display_short)|uniprotkb:Phosphatidylinositol 4-kinase TOR2(gene name synonym)|uniprotkb:Target of rapamycin kinase 2(gene name synonym)|uniprotkb:Dominant rapamycin resistance protein 2(gene name synonym)|uniprotkb:Temperature-sensitive CSG2 suppressor protein 14(gene name synonym)	psi-mi:lst8_yeast(display_long)|uniprotkb:Lethal with SEC13 protein 8(gene name synonym)|uniprotkb:YNL006W(locus name)|uniprotkb:N2005(orf name)|uniprotkb:LST8(gene name)|psi-mi:LST8(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Loewith et al. (2002)	pubmed:12408816|imex:IM-20364	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2434750|imex:IM-20364-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012719.2|sgd:S000001686|ensemblfungi:YKL203C(gene)|ensemblfungi:YKL203C_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0004430"(1-phosphatidylinositol 4-kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|go:"GO:0005739"(mitochondrion)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007049"(cell cycle)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905356"(regulation of snRNA pseudouridine synthesis)|go:"GO:2001108"(positive regulation of Rho guanyl-nucleotide exchange factor activity)|interpro:IPR018936|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|rcsb pdb:6EMK|reactome:R-SCE-1257604|reactome:R-SCE-3371571|reactome:R-SCE-389357|reactome:R-SCE-5218920|reactome:R-SCE-6804757|reactome:R-SCE-9639288|interpro:IPR024585|dip:DIP-2332N|mint:P32600	reactome:R-SCE-3371571|sgd:S000004951|refseq:NP_014392.3|dip:DIP-5318N|reactome:R-SCE-1257604|reactome:R-SCE-389357|reactome:R-SCE-5218920|reactome:R-SCE-6804757|reactome:R-SCE-9639288|ensemblfungi:YNL006W(gene)|ensemblfungi:YNL006W_mRNA(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0010008"(endosome membrane)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0031929"(TOR signaling)|go:"GO:0031930"(mitochondria-nucleus signaling pathway)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034399"(nuclear periphery)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR037588|rcsb pdb:6EMK	-	crc64:F2349690146058CF	crc64:536AA1DB8E8151F0	figure legend:Fig. 2C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/09/03	2014/10/16	rogid:7IgrRILayw94y5+JjCP2x5VLJ4g559292	rogid:DJkTl61Tdn8EtP/6tE7UFerq8w0559292	intact-crc:E126610C8962EB07|rigid:z6CBH/8LaHSNui4f0sf5AtjoYyM	false	ha tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P38873	uniprotkb:P41318	intact:EBI-24864|uniprotkb:D3DLD4|ensemblfungi:YHR186C	intact:EBI-28598|uniprotkb:D6W1H1|ensemblfungi:YNL006W	psi-mi:kog1_yeast(display_long)|uniprotkb:Kontroller of growth protein 1(gene name synonym)|uniprotkb:Local anesthetic-sensitive protein 24(gene name synonym)|uniprotkb:YHR186C(locus name)|uniprotkb:KOG1(gene name)|psi-mi:KOG1(display_short)|uniprotkb:LAS24(gene name synonym)|uniprotkb:H9998.14(orf name)	psi-mi:lst8_yeast(display_long)|uniprotkb:Lethal with SEC13 protein 8(gene name synonym)|uniprotkb:YNL006W(locus name)|uniprotkb:N2005(orf name)|uniprotkb:LST8(gene name)|psi-mi:LST8(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Loewith et al. (2002)	pubmed:12408816|imex:IM-20364	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2434762|imex:IM-20364-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012056.1|sgd:S000001229|mint:P38873|dip:DIP-2639N|ensemblfungi:YHR186C(gene)|ensemblfungi:YHR186C_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|interpro:IPR000357(HEAT)|interpro:IPR001680(WD40 repeat)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|reactome:R-SCE-3371571|reactome:R-SCE-9639288	reactome:R-SCE-3371571|sgd:S000004951|refseq:NP_014392.3|dip:DIP-5318N|reactome:R-SCE-1257604|reactome:R-SCE-389357|reactome:R-SCE-5218920|reactome:R-SCE-6804757|reactome:R-SCE-9639288|ensemblfungi:YNL006W(gene)|ensemblfungi:YNL006W_mRNA(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0010008"(endosome membrane)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0031929"(TOR signaling)|go:"GO:0031930"(mitochondria-nucleus signaling pathway)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034399"(nuclear periphery)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR037588|rcsb pdb:6EMK	-	crc64:B927EE93700176D3	crc64:536AA1DB8E8151F0	figure legend:Fig. 2C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/09/03	2014/10/16	rogid:8fDDVTuayLjREVAHrrpxJ9ExeCM559292	rogid:DJkTl61Tdn8EtP/6tE7UFerq8w0559292	intact-crc:665D1090AC07E048|rigid:0V7P7T8c/SAs8Eb/jQnaPUZo7dU	false	ha tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q08236	uniprotkb:P41318	intact:EBI-29284|uniprotkb:D6W1Y9|ensemblfungi:YOL078W	intact:EBI-28598|uniprotkb:D6W1H1|ensemblfungi:YNL006W	psi-mi:avo1_yeast(display_long)|uniprotkb:Adheres voraciously to TOR2 protein 1(gene name synonym)|uniprotkb:YOL078W(locus name)|uniprotkb:AVO1(gene name)|psi-mi:AVO1(display_short)|uniprotkb:O1110(orf name)	psi-mi:lst8_yeast(display_long)|uniprotkb:Lethal with SEC13 protein 8(gene name synonym)|uniprotkb:YNL006W(locus name)|uniprotkb:N2005(orf name)|uniprotkb:LST8(gene name)|psi-mi:LST8(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Loewith et al. (2002)	pubmed:12408816|imex:IM-20364	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2434771|imex:IM-20364-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014563.1|sgd:S000005438|dip:DIP-6357N|reactome:R-SCE-1257604|reactome:R-SCE-389357|reactome:R-SCE-5218920|reactome:R-SCE-6804757|ensemblfungi:YOL078W(gene)|ensemblfungi:YOL078W_mRNA(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0031929"(TOR signaling)|go:"GO:0031932"(TORC2 complex)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|interpro:IPR008828(Stress-activated map kinase interacting 1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR031313|interpro:IPR031567|rcsb pdb:3ULB|rcsb pdb:3ULC|rcsb pdb:6EMK	reactome:R-SCE-3371571|sgd:S000004951|refseq:NP_014392.3|dip:DIP-5318N|reactome:R-SCE-1257604|reactome:R-SCE-389357|reactome:R-SCE-5218920|reactome:R-SCE-6804757|reactome:R-SCE-9639288|ensemblfungi:YNL006W(gene)|ensemblfungi:YNL006W_mRNA(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0010008"(endosome membrane)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0031929"(TOR signaling)|go:"GO:0031930"(mitochondria-nucleus signaling pathway)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034399"(nuclear periphery)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR037588|rcsb pdb:6EMK	-	crc64:ED2B30D014EE5652	crc64:536AA1DB8E8151F0	figure legend:Fig. 2C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/09/03	2014/10/16	rogid:TzyrCBNOWYLrFV9+MUOnWXXvJYs559292	rogid:DJkTl61Tdn8EtP/6tE7UFerq8w0559292	intact-crc:040252004308F76F|rigid:Z6IHx4PoWdYDGf8eIQWdPwo7mqM	false	ha tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q04749	uniprotkb:P41318	intact:EBI-28131|uniprotkb:D6VZP2|ensemblfungi:YMR068W	intact:EBI-28598|uniprotkb:D6W1H1|ensemblfungi:YNL006W	psi-mi:avo2_yeast(display_long)|uniprotkb:YMR068W(locus name)|uniprotkb:YM9916.07(orf name)|uniprotkb:AVO2(gene name)|psi-mi:AVO2(display_short)|uniprotkb:Adheres voraciously to TOR2 protein 2(gene name synonym)	psi-mi:lst8_yeast(display_long)|uniprotkb:Lethal with SEC13 protein 8(gene name synonym)|uniprotkb:YNL006W(locus name)|uniprotkb:N2005(orf name)|uniprotkb:LST8(gene name)|psi-mi:LST8(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Loewith et al. (2002)	pubmed:12408816|imex:IM-20364	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2434780|imex:IM-20364-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013784.1|sgd:S000004672|dip:DIP-1958N|mint:Q04749|ensemblfungi:YMR068W(gene)|ensemblfungi:YMR068W_mRNA(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031929"(TOR signaling)|go:"GO:0031932"(TORC2 complex)|interpro:IPR002110(Ankyrin)|interpro:IPR036770|rcsb pdb:6EMK	reactome:R-SCE-3371571|sgd:S000004951|refseq:NP_014392.3|dip:DIP-5318N|reactome:R-SCE-1257604|reactome:R-SCE-389357|reactome:R-SCE-5218920|reactome:R-SCE-6804757|reactome:R-SCE-9639288|ensemblfungi:YNL006W(gene)|ensemblfungi:YNL006W_mRNA(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0010008"(endosome membrane)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0031929"(TOR signaling)|go:"GO:0031930"(mitochondria-nucleus signaling pathway)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034399"(nuclear periphery)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR037588|rcsb pdb:6EMK	-	-	crc64:536AA1DB8E8151F0	figure legend:Fig. 2C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/09/03	2014/10/16	rogid:T4jLsFiHINxRGduuu5DmqEPF3EE559292	rogid:DJkTl61Tdn8EtP/6tE7UFerq8w0559292	intact-crc:59305D3DE90ED316|rigid:+BoHhhBptWXXtUtsPrQlN1s/naA	false	ha tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P41318	uniprotkb:P40061	intact:EBI-28598|uniprotkb:D6W1H1|ensemblfungi:YNL006W	intact:EBI-22621|uniprotkb:D3DM00|ensemblfungi:YER093C	psi-mi:lst8_yeast(display_long)|uniprotkb:Lethal with SEC13 protein 8(gene name synonym)|uniprotkb:YNL006W(locus name)|uniprotkb:N2005(orf name)|uniprotkb:LST8(gene name)|psi-mi:LST8(display_short)	psi-mi:tsc11_yeast(display_long)|uniprotkb:AVO3(gene name synonym)|uniprotkb:YER093C(locus name)|uniprotkb:TSC11(gene name)|psi-mi:TSC11(display_short)|uniprotkb:Adheres voraciously to TOR2 protein 3(gene name synonym)|uniprotkb:Temperature-sensitive CSG2 suppressor protein 11(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Loewith et al. (2002)	pubmed:12408816|imex:IM-20364	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2434789|imex:IM-20364-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-SCE-3371571|sgd:S000004951|refseq:NP_014392.3|dip:DIP-5318N|reactome:R-SCE-1257604|reactome:R-SCE-389357|reactome:R-SCE-5218920|reactome:R-SCE-6804757|reactome:R-SCE-9639288|ensemblfungi:YNL006W(gene)|ensemblfungi:YNL006W_mRNA(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0010008"(endosome membrane)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0031929"(TOR signaling)|go:"GO:0031930"(mitochondria-nucleus signaling pathway)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034399"(nuclear periphery)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR037588|rcsb pdb:6EMK	refseq:NP_011018.1|sgd:S000000895|dip:DIP-4957N|mint:P40061|ensemblfungi:YER093C(gene)|ensemblfungi:YER093C_mRNA(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0031929"(TOR signaling)|go:"GO:0031932"(TORC2 complex)|go:"GO:0038203"(TORC2 signaling)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028267|interpro:IPR028268|interpro:IPR029451|interpro:IPR029452|interpro:IPR029453|reactome:R-SCE-1257604|reactome:R-SCE-389357|reactome:R-SCE-5218920|reactome:R-SCE-6804757	-	crc64:536AA1DB8E8151F0	crc64:07BB5D75BA204E50	figure legend:Fig. 2C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/09/03	2014/10/16	rogid:DJkTl61Tdn8EtP/6tE7UFerq8w0559292	rogid:VWXhP0KgrXl8YKFmjxSKYVJbMcQ559292	intact-crc:E1343D65907F3A8B|rigid:RwCK1puZHRE/XFtWU3NOYCXVTvo	false	ha tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P41318	uniprotkb:P32600	intact:EBI-28598|uniprotkb:D6W1H1|ensemblfungi:YNL006W	intact:EBI-19385|uniprotkb:D6VX00|ensemblfungi:YKL203C	psi-mi:lst8_yeast(display_long)|uniprotkb:Lethal with SEC13 protein 8(gene name synonym)|uniprotkb:YNL006W(locus name)|uniprotkb:N2005(orf name)|uniprotkb:LST8(gene name)|psi-mi:LST8(display_short)	psi-mi:tor2_yeast(display_long)|uniprotkb:DRR2(gene name synonym)|uniprotkb:TSC14(gene name synonym)|uniprotkb:YKL203C(locus name)|uniprotkb:TOR2(gene name)|psi-mi:TOR2(display_short)|uniprotkb:Phosphatidylinositol 4-kinase TOR2(gene name synonym)|uniprotkb:Target of rapamycin kinase 2(gene name synonym)|uniprotkb:Dominant rapamycin resistance protein 2(gene name synonym)|uniprotkb:Temperature-sensitive CSG2 suppressor protein 14(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Loewith et al. (2002)	pubmed:12408816|imex:IM-20364	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2434798|imex:IM-20364-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-SCE-3371571|sgd:S000004951|refseq:NP_014392.3|dip:DIP-5318N|reactome:R-SCE-1257604|reactome:R-SCE-389357|reactome:R-SCE-5218920|reactome:R-SCE-6804757|reactome:R-SCE-9639288|ensemblfungi:YNL006W(gene)|ensemblfungi:YNL006W_mRNA(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0010008"(endosome membrane)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0031929"(TOR signaling)|go:"GO:0031930"(mitochondria-nucleus signaling pathway)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034399"(nuclear periphery)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR037588|rcsb pdb:6EMK	refseq:NP_012719.2|sgd:S000001686|ensemblfungi:YKL203C(gene)|ensemblfungi:YKL203C_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0004430"(1-phosphatidylinositol 4-kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|go:"GO:0005739"(mitochondrion)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007049"(cell cycle)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905356"(regulation of snRNA pseudouridine synthesis)|go:"GO:2001108"(positive regulation of Rho guanyl-nucleotide exchange factor activity)|interpro:IPR018936|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|rcsb pdb:6EMK|reactome:R-SCE-1257604|reactome:R-SCE-3371571|reactome:R-SCE-389357|reactome:R-SCE-5218920|reactome:R-SCE-6804757|reactome:R-SCE-9639288|interpro:IPR024585|dip:DIP-2332N|mint:P32600	-	crc64:536AA1DB8E8151F0	crc64:F2349690146058CF	figure legend:Fig. 2C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/09/03	2014/10/16	rogid:DJkTl61Tdn8EtP/6tE7UFerq8w0559292	rogid:7IgrRILayw94y5+JjCP2x5VLJ4g559292	intact-crc:D75CB1419369A40C|rigid:z6CBH/8LaHSNui4f0sf5AtjoYyM	false	myc tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q04749	uniprotkb:Q08236	intact:EBI-28131|uniprotkb:D6VZP2|ensemblfungi:YMR068W	intact:EBI-29284|uniprotkb:D6W1Y9|ensemblfungi:YOL078W	psi-mi:avo2_yeast(display_long)|uniprotkb:YMR068W(locus name)|uniprotkb:YM9916.07(orf name)|uniprotkb:AVO2(gene name)|psi-mi:AVO2(display_short)|uniprotkb:Adheres voraciously to TOR2 protein 2(gene name synonym)	psi-mi:avo1_yeast(display_long)|uniprotkb:Adheres voraciously to TOR2 protein 1(gene name synonym)|uniprotkb:YOL078W(locus name)|uniprotkb:AVO1(gene name)|psi-mi:AVO1(display_short)|uniprotkb:O1110(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Loewith et al. (2002)	pubmed:12408816|imex:IM-20364	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2434807|imex:IM-20364-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013784.1|sgd:S000004672|dip:DIP-1958N|mint:Q04749|ensemblfungi:YMR068W(gene)|ensemblfungi:YMR068W_mRNA(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031929"(TOR signaling)|go:"GO:0031932"(TORC2 complex)|interpro:IPR002110(Ankyrin)|interpro:IPR036770|rcsb pdb:6EMK	refseq:NP_014563.1|sgd:S000005438|dip:DIP-6357N|reactome:R-SCE-1257604|reactome:R-SCE-389357|reactome:R-SCE-5218920|reactome:R-SCE-6804757|ensemblfungi:YOL078W(gene)|ensemblfungi:YOL078W_mRNA(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0031929"(TOR signaling)|go:"GO:0031932"(TORC2 complex)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|interpro:IPR008828(Stress-activated map kinase interacting 1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR031313|interpro:IPR031567|rcsb pdb:3ULB|rcsb pdb:3ULC|rcsb pdb:6EMK	-	-	crc64:ED2B30D014EE5652	figure legend:Fig. 2D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/09/03	2014/10/16	rogid:T4jLsFiHINxRGduuu5DmqEPF3EE559292	rogid:TzyrCBNOWYLrFV9+MUOnWXXvJYs559292	intact-crc:4FF7E70F6E42452E|rigid:7VKnWjBBpp2igtMHMHPr+0yy6qE	false	myc tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q08236	uniprotkb:P40061	intact:EBI-29284|uniprotkb:D6W1Y9|ensemblfungi:YOL078W	intact:EBI-22621|uniprotkb:D3DM00|ensemblfungi:YER093C	psi-mi:avo1_yeast(display_long)|uniprotkb:Adheres voraciously to TOR2 protein 1(gene name synonym)|uniprotkb:YOL078W(locus name)|uniprotkb:AVO1(gene name)|psi-mi:AVO1(display_short)|uniprotkb:O1110(orf name)	psi-mi:tsc11_yeast(display_long)|uniprotkb:AVO3(gene name synonym)|uniprotkb:YER093C(locus name)|uniprotkb:TSC11(gene name)|psi-mi:TSC11(display_short)|uniprotkb:Adheres voraciously to TOR2 protein 3(gene name synonym)|uniprotkb:Temperature-sensitive CSG2 suppressor protein 11(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Loewith et al. (2002)	pubmed:12408816|imex:IM-20364	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2434816|imex:IM-20364-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014563.1|sgd:S000005438|dip:DIP-6357N|reactome:R-SCE-1257604|reactome:R-SCE-389357|reactome:R-SCE-5218920|reactome:R-SCE-6804757|ensemblfungi:YOL078W(gene)|ensemblfungi:YOL078W_mRNA(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0031929"(TOR signaling)|go:"GO:0031932"(TORC2 complex)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|interpro:IPR008828(Stress-activated map kinase interacting 1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR031313|interpro:IPR031567|rcsb pdb:3ULB|rcsb pdb:3ULC|rcsb pdb:6EMK	refseq:NP_011018.1|sgd:S000000895|dip:DIP-4957N|mint:P40061|ensemblfungi:YER093C(gene)|ensemblfungi:YER093C_mRNA(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0031929"(TOR signaling)|go:"GO:0031932"(TORC2 complex)|go:"GO:0038203"(TORC2 signaling)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028267|interpro:IPR028268|interpro:IPR029451|interpro:IPR029452|interpro:IPR029453|reactome:R-SCE-1257604|reactome:R-SCE-389357|reactome:R-SCE-5218920|reactome:R-SCE-6804757	-	crc64:ED2B30D014EE5652	crc64:07BB5D75BA204E50	figure legend:Fig. 2D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/09/03	2014/10/16	rogid:TzyrCBNOWYLrFV9+MUOnWXXvJYs559292	rogid:VWXhP0KgrXl8YKFmjxSKYVJbMcQ559292	intact-crc:2BD50B086B743916|rigid:y5CjCBXPKFKABY+EmY4pz3HPpu8	false	ha tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q04749	uniprotkb:P40061	intact:EBI-28131|uniprotkb:D6VZP2|ensemblfungi:YMR068W	intact:EBI-22621|uniprotkb:D3DM00|ensemblfungi:YER093C	psi-mi:avo2_yeast(display_long)|uniprotkb:YMR068W(locus name)|uniprotkb:YM9916.07(orf name)|uniprotkb:AVO2(gene name)|psi-mi:AVO2(display_short)|uniprotkb:Adheres voraciously to TOR2 protein 2(gene name synonym)	psi-mi:tsc11_yeast(display_long)|uniprotkb:AVO3(gene name synonym)|uniprotkb:YER093C(locus name)|uniprotkb:TSC11(gene name)|psi-mi:TSC11(display_short)|uniprotkb:Adheres voraciously to TOR2 protein 3(gene name synonym)|uniprotkb:Temperature-sensitive CSG2 suppressor protein 11(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Loewith et al. (2002)	pubmed:12408816|imex:IM-20364	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2434825|imex:IM-20364-18	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013784.1|sgd:S000004672|dip:DIP-1958N|mint:Q04749|ensemblfungi:YMR068W(gene)|ensemblfungi:YMR068W_mRNA(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031929"(TOR signaling)|go:"GO:0031932"(TORC2 complex)|interpro:IPR002110(Ankyrin)|interpro:IPR036770|rcsb pdb:6EMK	refseq:NP_011018.1|sgd:S000000895|dip:DIP-4957N|mint:P40061|ensemblfungi:YER093C(gene)|ensemblfungi:YER093C_mRNA(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0031929"(TOR signaling)|go:"GO:0031932"(TORC2 complex)|go:"GO:0038203"(TORC2 signaling)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028267|interpro:IPR028268|interpro:IPR029451|interpro:IPR029452|interpro:IPR029453|reactome:R-SCE-1257604|reactome:R-SCE-389357|reactome:R-SCE-5218920|reactome:R-SCE-6804757	-	-	crc64:07BB5D75BA204E50	figure legend:Fig. 2E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/09/03	2014/10/16	rogid:T4jLsFiHINxRGduuu5DmqEPF3EE559292	rogid:VWXhP0KgrXl8YKFmjxSKYVJbMcQ559292	intact-crc:F4497BD925CFA4CD|rigid:GbhWzXvHKlfm3FHhKt/794OhBYQ	false	myc tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q04749	uniprotkb:P32600	intact:EBI-28131|uniprotkb:D6VZP2|ensemblfungi:YMR068W	intact:EBI-19385|uniprotkb:D6VX00|ensemblfungi:YKL203C	psi-mi:avo2_yeast(display_long)|uniprotkb:YMR068W(locus name)|uniprotkb:YM9916.07(orf name)|uniprotkb:AVO2(gene name)|psi-mi:AVO2(display_short)|uniprotkb:Adheres voraciously to TOR2 protein 2(gene name synonym)	psi-mi:tor2_yeast(display_long)|uniprotkb:DRR2(gene name synonym)|uniprotkb:TSC14(gene name synonym)|uniprotkb:YKL203C(locus name)|uniprotkb:TOR2(gene name)|psi-mi:TOR2(display_short)|uniprotkb:Phosphatidylinositol 4-kinase TOR2(gene name synonym)|uniprotkb:Target of rapamycin kinase 2(gene name synonym)|uniprotkb:Dominant rapamycin resistance protein 2(gene name synonym)|uniprotkb:Temperature-sensitive CSG2 suppressor protein 14(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Loewith et al. (2002)	pubmed:12408816|imex:IM-20364	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2434834|imex:IM-20364-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013784.1|sgd:S000004672|dip:DIP-1958N|mint:Q04749|ensemblfungi:YMR068W(gene)|ensemblfungi:YMR068W_mRNA(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031929"(TOR signaling)|go:"GO:0031932"(TORC2 complex)|interpro:IPR002110(Ankyrin)|interpro:IPR036770|rcsb pdb:6EMK	refseq:NP_012719.2|sgd:S000001686|ensemblfungi:YKL203C(gene)|ensemblfungi:YKL203C_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0004430"(1-phosphatidylinositol 4-kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|go:"GO:0005739"(mitochondrion)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007049"(cell cycle)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905356"(regulation of snRNA pseudouridine synthesis)|go:"GO:2001108"(positive regulation of Rho guanyl-nucleotide exchange factor activity)|interpro:IPR018936|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|rcsb pdb:6EMK|reactome:R-SCE-1257604|reactome:R-SCE-3371571|reactome:R-SCE-389357|reactome:R-SCE-5218920|reactome:R-SCE-6804757|reactome:R-SCE-9639288|interpro:IPR024585|dip:DIP-2332N|mint:P32600	-	-	crc64:F2349690146058CF	figure legend:Fig. 2E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/09/03	2014/10/16	rogid:T4jLsFiHINxRGduuu5DmqEPF3EE559292	rogid:7IgrRILayw94y5+JjCP2x5VLJ4g559292	intact-crc:E5FCE358BA5BD5A3|rigid:HOUooZ/+XQXNzqcKceYlYWa9yAE	false	myc tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P40061	uniprotkb:P32600	intact:EBI-22621|uniprotkb:D3DM00|ensemblfungi:YER093C	intact:EBI-19385|uniprotkb:D6VX00|ensemblfungi:YKL203C	psi-mi:tsc11_yeast(display_long)|uniprotkb:AVO3(gene name synonym)|uniprotkb:YER093C(locus name)|uniprotkb:TSC11(gene name)|psi-mi:TSC11(display_short)|uniprotkb:Adheres voraciously to TOR2 protein 3(gene name synonym)|uniprotkb:Temperature-sensitive CSG2 suppressor protein 11(gene name synonym)	psi-mi:tor2_yeast(display_long)|uniprotkb:DRR2(gene name synonym)|uniprotkb:TSC14(gene name synonym)|uniprotkb:YKL203C(locus name)|uniprotkb:TOR2(gene name)|psi-mi:TOR2(display_short)|uniprotkb:Phosphatidylinositol 4-kinase TOR2(gene name synonym)|uniprotkb:Target of rapamycin kinase 2(gene name synonym)|uniprotkb:Dominant rapamycin resistance protein 2(gene name synonym)|uniprotkb:Temperature-sensitive CSG2 suppressor protein 14(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Loewith et al. (2002)	pubmed:12408816|imex:IM-20364	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2434843|imex:IM-20364-20	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011018.1|sgd:S000000895|dip:DIP-4957N|mint:P40061|ensemblfungi:YER093C(gene)|ensemblfungi:YER093C_mRNA(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0031929"(TOR signaling)|go:"GO:0031932"(TORC2 complex)|go:"GO:0038203"(TORC2 signaling)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028267|interpro:IPR028268|interpro:IPR029451|interpro:IPR029452|interpro:IPR029453|reactome:R-SCE-1257604|reactome:R-SCE-389357|reactome:R-SCE-5218920|reactome:R-SCE-6804757	refseq:NP_012719.2|sgd:S000001686|ensemblfungi:YKL203C(gene)|ensemblfungi:YKL203C_mRNA(transcript)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0004430"(1-phosphatidylinositol 4-kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|go:"GO:0005739"(mitochondrion)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007049"(cell cycle)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905356"(regulation of snRNA pseudouridine synthesis)|go:"GO:2001108"(positive regulation of Rho guanyl-nucleotide exchange factor activity)|interpro:IPR018936|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|rcsb pdb:6EMK|reactome:R-SCE-1257604|reactome:R-SCE-3371571|reactome:R-SCE-389357|reactome:R-SCE-5218920|reactome:R-SCE-6804757|reactome:R-SCE-9639288|interpro:IPR024585|dip:DIP-2332N|mint:P32600	-	crc64:07BB5D75BA204E50	crc64:F2349690146058CF	figure legend:Fig. 2E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/09/03	2014/10/16	rogid:VWXhP0KgrXl8YKFmjxSKYVJbMcQ559292	rogid:7IgrRILayw94y5+JjCP2x5VLJ4g559292	intact-crc:7853A0BFAB2AE5B5|rigid:riDa4caLpRerAlgFa+v2xhzKO18	false	myc tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P42345	uniprotkb:Q8N122	intact:EBI-359260|uniprotkb:Q5TER1|uniprotkb:Q4LE76|uniprotkb:Q6LE87|uniprotkb:Q96QG3|uniprotkb:Q9Y4I3|ensembl:ENSP00000354558|intact:EBI-28989074	intact:EBI-1567928|uniprotkb:Q8N4V9|uniprotkb:Q8TB32|uniprotkb:Q9P2P3|uniprotkb:B2RN36|uniprotkb:C6KEF2|uniprotkb:F5H7J5|ensembl:ENSP00000307272	psi-mi:mtor_human(display_long)|uniprotkb:MTOR(gene name)|psi-mi:MTOR(display_short)|uniprotkb:FRAP(gene name synonym)|uniprotkb:FRAP2(gene name synonym)|uniprotkb:FK506-binding protein 12-rapamycin complex-associated protein 1(gene name synonym)|uniprotkb:Rapamycin target protein 1(gene name synonym)|uniprotkb:FRAP1(gene name synonym)|uniprotkb:Mammalian target of rapamycin(gene name synonym)|uniprotkb:FKBP12-rapamycin complex-associated protein(gene name synonym)|uniprotkb:Mechanistic target of rapamycin(gene name synonym)|uniprotkb:RAFT1(gene name synonym)|uniprotkb:RAPT1(gene name synonym)|uniprotkb:Rapamycin and FKBP12 target 1(gene name synonym)	psi-mi:rptor_human(display_long)|uniprotkb:"p150 target of rapamycin (TOR)-scaffold protein"(gene name synonym)|uniprotkb:RPTOR(gene name)|psi-mi:RPTOR(display_short)|uniprotkb:KIAA1303(gene name synonym)|uniprotkb:RAPTOR(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Loewith et al. (2002)	pubmed:12408816|imex:IM-20364	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2434906|imex:IM-20364-22	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000198793(gene)|refseq:NP_004949.1|ensembl:ENST00000361445(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001002"(RNA polymerase III type 1 promoter sequence-specific DNA binding)|go:"GO:0001003"(RNA polymerase III type 2 promoter sequence-specific DNA binding)|go:"GO:0001006"(RNA polymerase III type 3 promoter sequence-specific DNA binding)|go:"GO:0001156"(TFIIIC-class transcription factor complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002296"(T-helper 1 cell lineage commitment)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003179"(heart valve morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005764"(lysosome)|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6ZWM|rcsb pdb:6ZWO|reactome:R-HSA-1257604|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-3371571|reactome:R-HSA-380972|reactome:R-HSA-389357|reactome:R-HSA-5218920|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-6804757|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0012505"(endomembrane system)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030425"(dendrite)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0031998"(regulation of fatty acid beta-oxidation)|go:"GO:0032095"(regulation of response to food)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035176"(social behavior)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042060"(wound healing)|go:"GO:0042220"(response to cocaine)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043200"(response to amino acid)|go:"GO:0043276"(anoikis)|go:"GO:0043278"(response to morphine)|go:"GO:0043610"(regulation of carbohydrate utilization)|go:"GO:0045182"(translation regulator activity)|go:"GO:0014736"(negative regulation of muscle atrophy)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048511"(rhythmic process)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0051647"(nucleus localization)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090335"(regulation of brown fat cell differentiation)|go:"GO:0090559"(regulation of membrane permeability)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099547"(regulation of translation at synapse, modulating synaptic transmission)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1903691"(positive regulation of wound healing, spreading of epidermal cells)|go:"GO:1904000"(positive regulation of eating behavior)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0008542"(visual learning)|go:"GO:1904058"(positive regulation of sensory perception of pain)|go:"GO:1904059"(regulation of locomotor rhythm)|go:"GO:1904193"(negative regulation of cholangiocyte apoptotic process)|go:"GO:1904197"(positive regulation of granulosa cell proliferation)|go:"GO:1904206"(positive regulation of skeletal muscle hypertrophy)|go:"GO:1904213"(negative regulation of iodide transmembrane transport)|go:"GO:1904690"(positive regulation of cytoplasmic translational initiation)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR024585|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|mint:P42345|go:"GO:1904056"(positive regulation of cholangiocyte proliferation)|rcsb pdb:1FAP|rcsb pdb:1NSG|rcsb pdb:2FAP|rcsb pdb:2GAQ|rcsb pdb:2NPU|rcsb pdb:2RSE|rcsb pdb:3FAP|rcsb pdb:3JBZ|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRJ|rcsb pdb:4FAP|rcsb pdb:4JSN|rcsb pdb:4JSP|rcsb pdb:4JSV|rcsb pdb:4JSX|rcsb pdb:4JT5|rcsb pdb:4JT6|rcsb pdb:5FLC|rcsb pdb:5GPG|rcsb pdb:5H64|rcsb pdb:5WBH|rcsb pdb:5WBU|rcsb pdb:5WBY|rcsb pdb:5ZCS|rcsb pdb:6BCU|rcsb pdb:1AUE|rcsb pdb:6BCX|rcsb pdb:6M4U|rcsb pdb:6M4W|go:"GO:0005789"(endoplasmic reticulum membrane)|ensembl:ENSP00000354558|refseq:XP_005263495.1|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0005829"(cytosol)|go:"GO:0007040"(lysosome organization)|go:"GO:0007281"(germ cell development)|go:"GO:0007420"(brain development)|go:"GO:0007569"(cell aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007616"(long-term memory)|go:"GO:0008361"(regulation of cell size)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0006207"('de novo' pyrimidine nucleobase biosynthetic process)|go:"GO:0006468"(protein phosphorylation)|dip:DIP-790N	refseq:NP_001156506.1|refseq:NP_065812.1|dip:DIP-39482N|ensembl:ENSG00000141564(gene)|ensembl:ENST00000306801(transcript)|go:"GO:0001002"(RNA polymerase III type 1 promoter sequence-specific DNA binding)|go:"GO:0001003"(RNA polymerase III type 2 promoter sequence-specific DNA binding)|go:"GO:0001006"(RNA polymerase III type 3 promoter sequence-specific DNA binding)|go:"GO:0001156"(TFIIIC-class transcription factor complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009410"(response to xenobiotic stimulus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035176"(social behavior)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000357(HEAT)|interpro:IPR001680(WD40 repeat)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|mint:Q8N122|rcsb pdb:5H64|rcsb pdb:6BCU|rcsb pdb:6BCX|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-3371571|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. 7B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2009/09/03	2014/10/16	rogid:z6uJxqv906jKZ7IqoavN5JTWJs09606	rogid:BOvNcQXqn9hLPxAZeCZhKWbwgOk9606	intact-crc:1283C1C78C9ED3E9|rigid:dQs0nVDm5FWkds9pTVXtLjfPklc	false	ha tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P42345	uniprotkb:Q9BVC4	intact:EBI-359260|uniprotkb:Q5TER1|uniprotkb:Q4LE76|uniprotkb:Q6LE87|uniprotkb:Q96QG3|uniprotkb:Q9Y4I3|ensembl:ENSP00000354558|intact:EBI-28989074	intact:EBI-1387471|intact:EBI-1567843|uniprotkb:Q5M800|uniprotkb:Q86Y18|uniprotkb:Q8WUI5|uniprotkb:Q9HA66|uniprotkb:Q9UJV6|uniprotkb:B4DY00|uniprotkb:B3KMM4|uniprotkb:D3DU88|ensembl:ENSP00000380313|ensembl:ENSP00000455046|ensembl:ENSP00000456405|ensembl:ENSP00000457870	psi-mi:mtor_human(display_long)|uniprotkb:MTOR(gene name)|psi-mi:MTOR(display_short)|uniprotkb:FRAP(gene name synonym)|uniprotkb:FRAP2(gene name synonym)|uniprotkb:FK506-binding protein 12-rapamycin complex-associated protein 1(gene name synonym)|uniprotkb:Rapamycin target protein 1(gene name synonym)|uniprotkb:FRAP1(gene name synonym)|uniprotkb:Mammalian target of rapamycin(gene name synonym)|uniprotkb:FKBP12-rapamycin complex-associated protein(gene name synonym)|uniprotkb:Mechanistic target of rapamycin(gene name synonym)|uniprotkb:RAFT1(gene name synonym)|uniprotkb:RAPT1(gene name synonym)|uniprotkb:Rapamycin and FKBP12 target 1(gene name synonym)	psi-mi:lst8_human(display_long)|uniprotkb:MLST8(gene name)|psi-mi:MLST8(display_short)|uniprotkb:GBL(gene name synonym)|uniprotkb:G protein beta subunit-like(gene name synonym)|uniprotkb:LST8(gene name synonym)|uniprotkb:Mammalian lethal with SEC13 protein 8(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Loewith et al. (2002)	pubmed:12408816|imex:IM-20364	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2434924|imex:IM-20364-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000198793(gene)|refseq:NP_004949.1|ensembl:ENST00000361445(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001002"(RNA polymerase III type 1 promoter sequence-specific DNA binding)|go:"GO:0001003"(RNA polymerase III type 2 promoter sequence-specific DNA binding)|go:"GO:0001006"(RNA polymerase III type 3 promoter sequence-specific DNA binding)|go:"GO:0001156"(TFIIIC-class transcription factor complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002296"(T-helper 1 cell lineage commitment)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003179"(heart valve morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005764"(lysosome)|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6ZWM|rcsb pdb:6ZWO|reactome:R-HSA-1257604|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-3371571|reactome:R-HSA-380972|reactome:R-HSA-389357|reactome:R-HSA-5218920|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-6804757|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0012505"(endomembrane system)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030425"(dendrite)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0031998"(regulation of fatty acid beta-oxidation)|go:"GO:0032095"(regulation of response to food)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035176"(social behavior)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042060"(wound healing)|go:"GO:0042220"(response to cocaine)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043200"(response to amino acid)|go:"GO:0043276"(anoikis)|go:"GO:0043278"(response to morphine)|go:"GO:0043610"(regulation of carbohydrate utilization)|go:"GO:0045182"(translation regulator activity)|go:"GO:0014736"(negative regulation of muscle atrophy)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048511"(rhythmic process)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0051647"(nucleus localization)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090335"(regulation of brown fat cell differentiation)|go:"GO:0090559"(regulation of membrane permeability)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099547"(regulation of translation at synapse, modulating synaptic transmission)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1903691"(positive regulation of wound healing, spreading of epidermal cells)|go:"GO:1904000"(positive regulation of eating behavior)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0008542"(visual learning)|go:"GO:1904058"(positive regulation of sensory perception of pain)|go:"GO:1904059"(regulation of locomotor rhythm)|go:"GO:1904193"(negative regulation of cholangiocyte apoptotic process)|go:"GO:1904197"(positive regulation of granulosa cell proliferation)|go:"GO:1904206"(positive regulation of skeletal muscle hypertrophy)|go:"GO:1904213"(negative regulation of iodide transmembrane transport)|go:"GO:1904690"(positive regulation of cytoplasmic translational initiation)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR024585|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|mint:P42345|go:"GO:1904056"(positive regulation of cholangiocyte proliferation)|rcsb pdb:1FAP|rcsb pdb:1NSG|rcsb pdb:2FAP|rcsb pdb:2GAQ|rcsb pdb:2NPU|rcsb pdb:2RSE|rcsb pdb:3FAP|rcsb pdb:3JBZ|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRJ|rcsb pdb:4FAP|rcsb pdb:4JSN|rcsb pdb:4JSP|rcsb pdb:4JSV|rcsb pdb:4JSX|rcsb pdb:4JT5|rcsb pdb:4JT6|rcsb pdb:5FLC|rcsb pdb:5GPG|rcsb pdb:5H64|rcsb pdb:5WBH|rcsb pdb:5WBU|rcsb pdb:5WBY|rcsb pdb:5ZCS|rcsb pdb:6BCU|rcsb pdb:1AUE|rcsb pdb:6BCX|rcsb pdb:6M4U|rcsb pdb:6M4W|go:"GO:0005789"(endoplasmic reticulum membrane)|ensembl:ENSP00000354558|refseq:XP_005263495.1|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0005829"(cytosol)|go:"GO:0007040"(lysosome organization)|go:"GO:0007281"(germ cell development)|go:"GO:0007420"(brain development)|go:"GO:0007569"(cell aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007616"(long-term memory)|go:"GO:0008361"(regulation of cell size)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0006207"('de novo' pyrimidine nucleobase biosynthetic process)|go:"GO:0006468"(protein phosphorylation)|dip:DIP-790N	refseq:NP_001186102.1|refseq:NP_001186103.1|refseq:NP_001186104.1|refseq:NP_071767.3|refseq:XP_016879037.1|refseq:XP_016879038.1|dip:DIP-39481N|ensembl:ENSG00000167965(gene)|ensembl:ENST00000397124(transcript)|ensembl:ENST00000564088(transcript)|ensembl:ENST00000565250(transcript)|ensembl:ENST00000569417(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|interpro:IPR001680(WD40 repeat)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR037588|mint:Q9BVC4|rcsb pdb:4JSN|rcsb pdb:4JSP|rcsb pdb:4JSV|rcsb pdb:4JSX|rcsb pdb:4JT5|rcsb pdb:4JT6|rcsb pdb:5FLC|rcsb pdb:5H64|rcsb pdb:5WBU|rcsb pdb:5WBY|rcsb pdb:5ZCS|rcsb pdb:6BCU|rcsb pdb:6BCX|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6ZWM|rcsb pdb:6ZWO|reactome:R-HSA-1257604|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-3371571|reactome:R-HSA-380972|reactome:R-HSA-389357|reactome:R-HSA-5218920|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-6804757|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. 7B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2009/09/03	2014/10/16	rogid:z6uJxqv906jKZ7IqoavN5JTWJs09606	rogid:BQek96xYe/1IaE8vgX3Uvl9vkCc9606	intact-crc:8FE6746F55984D30|rigid:WCz9OpZdroomcAYa1Xb91s4qbT4	false	ha tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9BVC4	uniprotkb:Q8N122	intact:EBI-1387471|intact:EBI-1567843|uniprotkb:Q5M800|uniprotkb:Q86Y18|uniprotkb:Q8WUI5|uniprotkb:Q9HA66|uniprotkb:Q9UJV6|uniprotkb:B4DY00|uniprotkb:B3KMM4|uniprotkb:D3DU88|ensembl:ENSP00000380313|ensembl:ENSP00000455046|ensembl:ENSP00000456405|ensembl:ENSP00000457870	intact:EBI-1567928|uniprotkb:Q8N4V9|uniprotkb:Q8TB32|uniprotkb:Q9P2P3|uniprotkb:B2RN36|uniprotkb:C6KEF2|uniprotkb:F5H7J5|ensembl:ENSP00000307272	psi-mi:lst8_human(display_long)|uniprotkb:MLST8(gene name)|psi-mi:MLST8(display_short)|uniprotkb:GBL(gene name synonym)|uniprotkb:G protein beta subunit-like(gene name synonym)|uniprotkb:LST8(gene name synonym)|uniprotkb:Mammalian lethal with SEC13 protein 8(gene name synonym)	psi-mi:rptor_human(display_long)|uniprotkb:"p150 target of rapamycin (TOR)-scaffold protein"(gene name synonym)|uniprotkb:RPTOR(gene name)|psi-mi:RPTOR(display_short)|uniprotkb:KIAA1303(gene name synonym)|uniprotkb:RAPTOR(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Loewith et al. (2002)	pubmed:12408816|imex:IM-20364	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2434947|imex:IM-20364-24	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001186102.1|refseq:NP_001186103.1|refseq:NP_001186104.1|refseq:NP_071767.3|refseq:XP_016879037.1|refseq:XP_016879038.1|dip:DIP-39481N|ensembl:ENSG00000167965(gene)|ensembl:ENST00000397124(transcript)|ensembl:ENST00000564088(transcript)|ensembl:ENST00000565250(transcript)|ensembl:ENST00000569417(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|interpro:IPR001680(WD40 repeat)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR037588|mint:Q9BVC4|rcsb pdb:4JSN|rcsb pdb:4JSP|rcsb pdb:4JSV|rcsb pdb:4JSX|rcsb pdb:4JT5|rcsb pdb:4JT6|rcsb pdb:5FLC|rcsb pdb:5H64|rcsb pdb:5WBU|rcsb pdb:5WBY|rcsb pdb:5ZCS|rcsb pdb:6BCU|rcsb pdb:6BCX|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6ZWM|rcsb pdb:6ZWO|reactome:R-HSA-1257604|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-3371571|reactome:R-HSA-380972|reactome:R-HSA-389357|reactome:R-HSA-5218920|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-6804757|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_001156506.1|refseq:NP_065812.1|dip:DIP-39482N|ensembl:ENSG00000141564(gene)|ensembl:ENST00000306801(transcript)|go:"GO:0001002"(RNA polymerase III type 1 promoter sequence-specific DNA binding)|go:"GO:0001003"(RNA polymerase III type 2 promoter sequence-specific DNA binding)|go:"GO:0001006"(RNA polymerase III type 3 promoter sequence-specific DNA binding)|go:"GO:0001156"(TFIIIC-class transcription factor complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009410"(response to xenobiotic stimulus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035176"(social behavior)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000357(HEAT)|interpro:IPR001680(WD40 repeat)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|mint:Q8N122|rcsb pdb:5H64|rcsb pdb:6BCU|rcsb pdb:6BCX|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-3371571|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. 7C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2009/09/03	2014/10/16	rogid:BQek96xYe/1IaE8vgX3Uvl9vkCc9606	rogid:BOvNcQXqn9hLPxAZeCZhKWbwgOk9606	intact-crc:28361444CEBF3AAD|rigid:YPQxMMG5ATveNiTmXgUf7YAhR44	false	myc tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9BVC4	uniprotkb:Q8N122	intact:EBI-1387471|intact:EBI-1567843|uniprotkb:Q5M800|uniprotkb:Q86Y18|uniprotkb:Q8WUI5|uniprotkb:Q9HA66|uniprotkb:Q9UJV6|uniprotkb:B4DY00|uniprotkb:B3KMM4|uniprotkb:D3DU88|ensembl:ENSP00000380313|ensembl:ENSP00000455046|ensembl:ENSP00000456405|ensembl:ENSP00000457870	intact:EBI-1567928|uniprotkb:Q8N4V9|uniprotkb:Q8TB32|uniprotkb:Q9P2P3|uniprotkb:B2RN36|uniprotkb:C6KEF2|uniprotkb:F5H7J5|ensembl:ENSP00000307272	psi-mi:lst8_human(display_long)|uniprotkb:MLST8(gene name)|psi-mi:MLST8(display_short)|uniprotkb:GBL(gene name synonym)|uniprotkb:G protein beta subunit-like(gene name synonym)|uniprotkb:LST8(gene name synonym)|uniprotkb:Mammalian lethal with SEC13 protein 8(gene name synonym)	psi-mi:rptor_human(display_long)|uniprotkb:"p150 target of rapamycin (TOR)-scaffold protein"(gene name synonym)|uniprotkb:RPTOR(gene name)|psi-mi:RPTOR(display_short)|uniprotkb:KIAA1303(gene name synonym)|uniprotkb:RAPTOR(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Loewith et al. (2002)	pubmed:12408816|imex:IM-20364	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2434968|imex:IM-20364-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001186102.1|refseq:NP_001186103.1|refseq:NP_001186104.1|refseq:NP_071767.3|refseq:XP_016879037.1|refseq:XP_016879038.1|dip:DIP-39481N|ensembl:ENSG00000167965(gene)|ensembl:ENST00000397124(transcript)|ensembl:ENST00000564088(transcript)|ensembl:ENST00000565250(transcript)|ensembl:ENST00000569417(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|interpro:IPR001680(WD40 repeat)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR037588|mint:Q9BVC4|rcsb pdb:4JSN|rcsb pdb:4JSP|rcsb pdb:4JSV|rcsb pdb:4JSX|rcsb pdb:4JT5|rcsb pdb:4JT6|rcsb pdb:5FLC|rcsb pdb:5H64|rcsb pdb:5WBU|rcsb pdb:5WBY|rcsb pdb:5ZCS|rcsb pdb:6BCU|rcsb pdb:6BCX|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6ZWM|rcsb pdb:6ZWO|reactome:R-HSA-1257604|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-3371571|reactome:R-HSA-380972|reactome:R-HSA-389357|reactome:R-HSA-5218920|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-6804757|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_001156506.1|refseq:NP_065812.1|dip:DIP-39482N|ensembl:ENSG00000141564(gene)|ensembl:ENST00000306801(transcript)|go:"GO:0001002"(RNA polymerase III type 1 promoter sequence-specific DNA binding)|go:"GO:0001003"(RNA polymerase III type 2 promoter sequence-specific DNA binding)|go:"GO:0001006"(RNA polymerase III type 3 promoter sequence-specific DNA binding)|go:"GO:0001156"(TFIIIC-class transcription factor complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009410"(response to xenobiotic stimulus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035176"(social behavior)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000357(HEAT)|interpro:IPR001680(WD40 repeat)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|mint:Q8N122|rcsb pdb:5H64|rcsb pdb:6BCU|rcsb pdb:6BCX|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-3371571|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. 7C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2009/09/03	2014/10/16	rogid:BQek96xYe/1IaE8vgX3Uvl9vkCc9606	rogid:BOvNcQXqn9hLPxAZeCZhKWbwgOk9606	intact-crc:D0366ED2AD2A5C5F|rigid:YPQxMMG5ATveNiTmXgUf7YAhR44	false	myc tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)