#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q62233	uniprotkb:P63002	intact:EBI-2297327|uniprotkb:P70176|uniprotkb:P70177|uniprotkb:Q4QQQ3|ensembl:ENSMUSP00000135312|ensembl:ENSMUSP00000135677	intact:EBI-646888|uniprotkb:Q06195|ensembl:ENSMUSP00000002518	psi-mi:six3_mouse(display_long)|uniprotkb:Six3(gene name)|psi-mi:Six3(display_short)|uniprotkb:Sine oculis homeobox homolog 3(gene name synonym)	psi-mi:tle5_mouse(display_long)|uniprotkb:Tle5(gene name)|psi-mi:Tle5(display_short)|uniprotkb:Aes(gene name synonym)|uniprotkb:Amino-terminal enhancer of split(gene name synonym)|uniprotkb:Esp1(gene name synonym)|uniprotkb:Grg(gene name synonym)|uniprotkb:Grg-5(gene name synonym)|uniprotkb:Grg5(gene name synonym)|uniprotkb:Groucho-related protein 5(gene name synonym)|uniprotkb:Protein ESP1(gene name synonym)|uniprotkb:Protein GRG(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhu et al. (2002)	pubmed:12050133|imex:IM-20286	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2297360|imex:IM-20286-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035511.2|dip:DIP-46499N|ensembl:ENSMUSG00000038805(gene)|ensembl:ENSMUST00000175898(transcript)|ensembl:ENSMUST00000176081(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001654"(eye development)|go:"GO:0002070"(epithelial cell maturation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003404"(optic vesicle morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007420"(brain development)|go:"GO:0008406"(gonad development)|go:"GO:0009946"(proximal/distal axis specification)|go:"GO:0014016"(neuroblast differentiation)|go:"GO:0021536"(diencephalon development)|go:"GO:0021537"(telencephalon development)|go:"GO:0021797"(forebrain anterior/posterior pattern specification)|go:"GO:0021798"(forebrain dorsal/ventral pattern formation)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030878"(thyroid gland development)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048512"(circadian behavior)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0061074"(regulation of neural retina development)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0097402"(neuroblast migration)|go:"GO:1901987"(regulation of cell cycle phase transition)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1990086"(lens fiber cell apoptotic process)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR031701|interpro:IPR032949	refseq:NP_034477.1|ensembl:ENSMUSG00000054452(gene)|ensembl:ENSMUST00000002518(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0040008"(regulation of growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000210"(positive regulation of anoikis)|interpro:IPR005617(Groucho/TLE, N-terminal Q-rich region)|interpro:IPR009146(Groucho/transducin-like enhancer)|mint:P63002	-	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/03/31	2014/10/16	rogid:2L0pSyki8qB2GWxiSfs9M1ruwXM10090	rogid:3rMMpP0J+0tEUlSLA/PofvANFjU10090	intact-crc:A6F84B8563B1165F|rigid:y8j+6+0pF9d8npaBSGar4aM6ctw	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q62233	uniprotkb:P63002	intact:EBI-2297327|uniprotkb:P70176|uniprotkb:P70177|uniprotkb:Q4QQQ3|ensembl:ENSMUSP00000135312|ensembl:ENSMUSP00000135677	intact:EBI-646888|uniprotkb:Q06195|ensembl:ENSMUSP00000002518	psi-mi:six3_mouse(display_long)|uniprotkb:Six3(gene name)|psi-mi:Six3(display_short)|uniprotkb:Sine oculis homeobox homolog 3(gene name synonym)	psi-mi:tle5_mouse(display_long)|uniprotkb:Tle5(gene name)|psi-mi:Tle5(display_short)|uniprotkb:Aes(gene name synonym)|uniprotkb:Amino-terminal enhancer of split(gene name synonym)|uniprotkb:Esp1(gene name synonym)|uniprotkb:Grg(gene name synonym)|uniprotkb:Grg-5(gene name synonym)|uniprotkb:Grg5(gene name synonym)|uniprotkb:Groucho-related protein 5(gene name synonym)|uniprotkb:Protein ESP1(gene name synonym)|uniprotkb:Protein GRG(gene name synonym)	psi-mi:"MI:0096"(pull down)	Zhu et al. (2002)	pubmed:12050133|imex:IM-20286	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2297574|imex:IM-20286-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035511.2|dip:DIP-46499N|ensembl:ENSMUSG00000038805(gene)|ensembl:ENSMUST00000175898(transcript)|ensembl:ENSMUST00000176081(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001654"(eye development)|go:"GO:0002070"(epithelial cell maturation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003404"(optic vesicle morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007420"(brain development)|go:"GO:0008406"(gonad development)|go:"GO:0009946"(proximal/distal axis specification)|go:"GO:0014016"(neuroblast differentiation)|go:"GO:0021536"(diencephalon development)|go:"GO:0021537"(telencephalon development)|go:"GO:0021797"(forebrain anterior/posterior pattern specification)|go:"GO:0021798"(forebrain dorsal/ventral pattern formation)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030878"(thyroid gland development)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048512"(circadian behavior)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0061074"(regulation of neural retina development)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0097402"(neuroblast migration)|go:"GO:1901987"(regulation of cell cycle phase transition)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1990086"(lens fiber cell apoptotic process)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR031701|interpro:IPR032949	refseq:NP_034477.1|ensembl:ENSMUSG00000054452(gene)|ensembl:ENSMUST00000002518(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0040008"(regulation of growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000210"(positive regulation of anoikis)|interpro:IPR005617(Groucho/TLE, N-terminal Q-rich region)|interpro:IPR009146(Groucho/transducin-like enhancer)|mint:P63002	-	-	-	figure legend:2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/03/31	2014/10/16	rogid:2L0pSyki8qB2GWxiSfs9M1ruwXM10090	rogid:3rMMpP0J+0tEUlSLA/PofvANFjU10090	intact-crc:4F87F29282DDCD16|rigid:y8j+6+0pF9d8npaBSGar4aM6ctw	false	35s radiolabel:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P63002	uniprotkb:Q9QZ28	intact:EBI-646888|uniprotkb:Q06195|ensembl:ENSMUSP00000002518	intact:EBI-348987|uniprotkb:O88423|ensembl:ENSMUSP00000021519	psi-mi:tle5_mouse(display_long)|uniprotkb:Tle5(gene name)|psi-mi:Tle5(display_short)|uniprotkb:Aes(gene name synonym)|uniprotkb:Amino-terminal enhancer of split(gene name synonym)|uniprotkb:Esp1(gene name synonym)|uniprotkb:Grg(gene name synonym)|uniprotkb:Grg-5(gene name synonym)|uniprotkb:Grg5(gene name synonym)|uniprotkb:Groucho-related protein 5(gene name synonym)|uniprotkb:Protein ESP1(gene name synonym)|uniprotkb:Protein GRG(gene name synonym)	psi-mi:six6_mouse(display_long)|uniprotkb:Six6(gene name)|psi-mi:Six6(display_short)|uniprotkb:Optx2(gene name synonym)|uniprotkb:Six9(gene name synonym)|uniprotkb:Sine oculis homeobox homolog 6(gene name synonym)|uniprotkb:Optic homeobox 2(gene name synonym)|uniprotkb:Six9 protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Zhu et al. (2002)	pubmed:12050133|imex:IM-20286	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0197"(deacetylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2297845|imex:IM-20286-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034477.1|ensembl:ENSMUSG00000054452(gene)|ensembl:ENSMUST00000002518(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0040008"(regulation of growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000210"(positive regulation of anoikis)|interpro:IPR005617(Groucho/TLE, N-terminal Q-rich region)|interpro:IPR009146(Groucho/transducin-like enhancer)|mint:P63002	refseq:NP_035514.1|ensembl:ENSMUSG00000021099(gene)|ensembl:ENSMUST00000021519(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001654"(eye development)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR031701|interpro:IPR032947	-	-	-	figure legend:2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/03/31	2014/10/16	rogid:3rMMpP0J+0tEUlSLA/PofvANFjU10090	rogid:LE6vGckqrqLOASpqOf6dhsyntYI10090	intact-crc:52F4F09DCA5B74D3|rigid:pkOT+INhDufnq0zbT/95qtWHDvg	false	glutathione s tranferase tag:?-?	35s radiolabel:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P63002	uniprotkb:Q27350	intact:EBI-646888|uniprotkb:Q06195|ensembl:ENSMUSP00000002518	intact:EBI-161504|intact:EBI-1631381|uniprotkb:A0AVT8|uniprotkb:Q9V4L0|ensemblmetazoa:FBpp0089177	psi-mi:tle5_mouse(display_long)|uniprotkb:Tle5(gene name)|psi-mi:Tle5(display_short)|uniprotkb:Aes(gene name synonym)|uniprotkb:Amino-terminal enhancer of split(gene name synonym)|uniprotkb:Esp1(gene name synonym)|uniprotkb:Grg(gene name synonym)|uniprotkb:Grg-5(gene name synonym)|uniprotkb:Grg5(gene name synonym)|uniprotkb:Groucho-related protein 5(gene name synonym)|uniprotkb:Protein ESP1(gene name synonym)|uniprotkb:Protein GRG(gene name synonym)	psi-mi:so_drome(display_long)|uniprotkb:so(gene name)|psi-mi:so(display_short)|uniprotkb:CG11121(orf name)	psi-mi:"MI:0096"(pull down)	Zhu et al. (2002)	pubmed:12050133|imex:IM-20286	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2297852|imex:IM-20286-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034477.1|ensembl:ENSMUSG00000054452(gene)|ensembl:ENSMUST00000002518(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0040008"(regulation of growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000210"(positive regulation of anoikis)|interpro:IPR005617(Groucho/TLE, N-terminal Q-rich region)|interpro:IPR009146(Groucho/transducin-like enhancer)|mint:P63002	refseq:NP_476733.1|flybase:FBgn0003460|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008347"(glial cell migration)|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0035271"(ring gland development)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048749"(compound eye development)|ensemblmetazoa:FBgn0003460(gene)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR031701|ensemblmetazoa:FBtr0088970(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001744"(insect visual primordium formation)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0001746"(Bolwig's organ morphogenesis)|dip:DIP-18228N	-	-	-	figure legend:2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/03/31	2014/10/16	rogid:3rMMpP0J+0tEUlSLA/PofvANFjU10090	rogid:TnP/raOhk9Hfkp45tH8n+HW1UI07227	intact-crc:79CBB9FB192E36D5|rigid:VhnG8CMUj3v0lj4XUMH46/qJl7E	false	glutathione s tranferase tag:?-?	35s radiolabel:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q62233	uniprotkb:Q62441	intact:EBI-2297327|uniprotkb:P70176|uniprotkb:P70177|uniprotkb:Q4QQQ3|ensembl:ENSMUSP00000135312|ensembl:ENSMUSP00000135677	intact:EBI-2297871|uniprotkb:Q9JKQ9|ensembl:ENSMUSP00000057527	psi-mi:six3_mouse(display_long)|uniprotkb:Six3(gene name)|psi-mi:Six3(display_short)|uniprotkb:Sine oculis homeobox homolog 3(gene name synonym)	psi-mi:tle4_mouse(display_long)|uniprotkb:Tle4(gene name)|psi-mi:Tle4(display_short)|uniprotkb:Grg4(gene name synonym)|uniprotkb:Groucho-related protein 4(gene name synonym)|uniprotkb:Grg-4(gene name synonym)	psi-mi:"MI:0096"(pull down)	Zhu et al. (2002)	pubmed:12050133|imex:IM-20286	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2297893|imex:IM-20286-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035511.2|dip:DIP-46499N|ensembl:ENSMUSG00000038805(gene)|ensembl:ENSMUST00000175898(transcript)|ensembl:ENSMUST00000176081(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001654"(eye development)|go:"GO:0002070"(epithelial cell maturation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003404"(optic vesicle morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007420"(brain development)|go:"GO:0008406"(gonad development)|go:"GO:0009946"(proximal/distal axis specification)|go:"GO:0014016"(neuroblast differentiation)|go:"GO:0021536"(diencephalon development)|go:"GO:0021537"(telencephalon development)|go:"GO:0021797"(forebrain anterior/posterior pattern specification)|go:"GO:0021798"(forebrain dorsal/ventral pattern formation)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030878"(thyroid gland development)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048512"(circadian behavior)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0061074"(regulation of neural retina development)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0097402"(neuroblast migration)|go:"GO:1901987"(regulation of cell cycle phase transition)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1990086"(lens fiber cell apoptotic process)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR031701|interpro:IPR032949	refseq:NP_035730.2|ensembl:ENSMUSG00000024642(gene)|ensembl:ENSMUST00000052011(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR005617(Groucho/TLE, N-terminal Q-rich region)|interpro:IPR009146(Groucho/transducin-like enhancer)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|reactome:R-MMU-201722|reactome:R-MMU-3769402|reactome:R-MMU-4641265	-	-	-	figure legend:2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/03/31	2014/10/16	rogid:2L0pSyki8qB2GWxiSfs9M1ruwXM10090	rogid:xNGIMU4i7uY1bzWCV79+KsY+zW010090	intact-crc:0E79DCB10E4C4D9D|rigid:WfBmVBipjPIY1xdhIcLm2VP7TZA	false	35s radiolabel:?-?|mutation decreasing interaction:88-88	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q62441	uniprotkb:Q9QZ28	intact:EBI-2297871|uniprotkb:Q9JKQ9|ensembl:ENSMUSP00000057527	intact:EBI-348987|uniprotkb:O88423|ensembl:ENSMUSP00000021519	psi-mi:tle4_mouse(display_long)|uniprotkb:Tle4(gene name)|psi-mi:Tle4(display_short)|uniprotkb:Grg4(gene name synonym)|uniprotkb:Groucho-related protein 4(gene name synonym)|uniprotkb:Grg-4(gene name synonym)	psi-mi:six6_mouse(display_long)|uniprotkb:Six6(gene name)|psi-mi:Six6(display_short)|uniprotkb:Optx2(gene name synonym)|uniprotkb:Six9(gene name synonym)|uniprotkb:Sine oculis homeobox homolog 6(gene name synonym)|uniprotkb:Optic homeobox 2(gene name synonym)|uniprotkb:Six9 protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Zhu et al. (2002)	pubmed:12050133|imex:IM-20286	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2297904|imex:IM-20286-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035730.2|ensembl:ENSMUSG00000024642(gene)|ensembl:ENSMUST00000052011(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR005617(Groucho/TLE, N-terminal Q-rich region)|interpro:IPR009146(Groucho/transducin-like enhancer)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|reactome:R-MMU-201722|reactome:R-MMU-3769402|reactome:R-MMU-4641265	refseq:NP_035514.1|ensembl:ENSMUSG00000021099(gene)|ensembl:ENSMUST00000021519(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001654"(eye development)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR031701|interpro:IPR032947	-	-	-	figure legend:2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/03/31	2014/10/16	rogid:xNGIMU4i7uY1bzWCV79+KsY+zW010090	rogid:LE6vGckqrqLOASpqOf6dhsyntYI10090	intact-crc:E4E562A7C23D4696|rigid:3+d2gCbqCE/y2lG2siJq5AiOibg	false	glutathione s tranferase tag:?-?	35s radiolabel:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q95RW8	uniprotkb:Q62441	intact:EBI-2297912|uniprotkb:O76291|uniprotkb:Q8MKN3|uniprotkb:Q9UA64|uniprotkb:Q9V355|ensemblmetazoa:FBpp0087941	intact:EBI-2297871|uniprotkb:Q9JKQ9|ensembl:ENSMUSP00000057527	psi-mi:optix_drome(display_long)|uniprotkb:Optix(gene name)|psi-mi:Optix(display_short)|uniprotkb:opt(gene name synonym)|uniprotkb:Six3(gene name synonym)|uniprotkb:Homeobox protein SIX3(gene name synonym)|uniprotkb:CG18455(orf name)	psi-mi:tle4_mouse(display_long)|uniprotkb:Tle4(gene name)|psi-mi:Tle4(display_short)|uniprotkb:Grg4(gene name synonym)|uniprotkb:Groucho-related protein 4(gene name synonym)|uniprotkb:Grg-4(gene name synonym)	psi-mi:"MI:0096"(pull down)	Zhu et al. (2002)	pubmed:12050133|imex:IM-20286	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2297945|imex:IM-20286-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_524695.2|refseq:NP_724640.1|flybase:FBgn0025360|ensemblmetazoa:FBgn0025360(gene)|ensemblmetazoa:FBtr0088865(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0001751"(compound eye photoreceptor cell differentiation)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007458"(progression of morphogenetic furrow involved in compound eye morphogenesis)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048749"(compound eye development)|go:"GO:0048813"(dendrite morphogenesis)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR031701	refseq:NP_035730.2|ensembl:ENSMUSG00000024642(gene)|ensembl:ENSMUST00000052011(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR005617(Groucho/TLE, N-terminal Q-rich region)|interpro:IPR009146(Groucho/transducin-like enhancer)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|reactome:R-MMU-201722|reactome:R-MMU-3769402|reactome:R-MMU-4641265	-	-	-	figure legend:2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/03/31	2014/10/16	rogid:ZrfEewVVseZbJOjvVxIuRI/dySg7227	rogid:xNGIMU4i7uY1bzWCV79+KsY+zW010090	intact-crc:82434E30E5DABB4D|rigid:hXd6m1kT7siKxY9GbWNr5GvQIBI	false	35s radiolabel:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P16371	uniprotkb:Q62233	intact:EBI-153866|intact:EBI-1639108|uniprotkb:Q0KI08|uniprotkb:Q7KRZ4|uniprotkb:Q9V3F7|uniprotkb:A4V3F6|ensemblmetazoa:FBpp0089115	intact:EBI-2297327|uniprotkb:P70176|uniprotkb:P70177|uniprotkb:Q4QQQ3|ensembl:ENSMUSP00000135312|ensembl:ENSMUSP00000135677	psi-mi:grou_drome(display_long)|uniprotkb:gro(gene name)|psi-mi:gro(display_short)|uniprotkb:"E(spl)m9/m10"(gene name synonym)|uniprotkb:CG8384(orf name)|uniprotkb:Enhancer of split m9/10 protein(gene name synonym)	psi-mi:six3_mouse(display_long)|uniprotkb:Six3(gene name)|psi-mi:Six3(display_short)|uniprotkb:Sine oculis homeobox homolog 3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Zhu et al. (2002)	pubmed:12050133|imex:IM-20286	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2297953|imex:IM-20286-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001189293.1|refseq:NP_524514.2|refseq:NP_733133.1|refseq:NP_733134.1|refseq:NP_733135.1|refseq:NP_996298.1|flybase:FBgn0001139|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0071837"(HMG box domain binding)|go:"GO:0071906"(CRD domain binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR005617(Groucho/TLE, N-terminal Q-rich region)|interpro:IPR009146(Groucho/transducin-like enhancer)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|mint:P16371|reactome:R-DME-201722|reactome:R-DME-209421|reactome:R-DME-209441|reactome:R-DME-3769402|reactome:R-DME-4641265|go:"GO:0045751"(negative regulation of Toll signaling pathway)|ensemblmetazoa:FBgn0001139(gene)|ensemblmetazoa:FBtr0084966(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007541"("sex determination, primary response to X:A ratio")|go:"GO:0008134"(transcription factor binding)|go:"GO:0008293"(torso signaling pathway)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0032991"(protein-containing complex)|dip:DIP-40N	refseq:NP_035511.2|dip:DIP-46499N|ensembl:ENSMUSG00000038805(gene)|ensembl:ENSMUST00000175898(transcript)|ensembl:ENSMUST00000176081(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001654"(eye development)|go:"GO:0002070"(epithelial cell maturation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003404"(optic vesicle morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007420"(brain development)|go:"GO:0008406"(gonad development)|go:"GO:0009946"(proximal/distal axis specification)|go:"GO:0014016"(neuroblast differentiation)|go:"GO:0021536"(diencephalon development)|go:"GO:0021537"(telencephalon development)|go:"GO:0021797"(forebrain anterior/posterior pattern specification)|go:"GO:0021798"(forebrain dorsal/ventral pattern formation)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030878"(thyroid gland development)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048512"(circadian behavior)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0061074"(regulation of neural retina development)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0097402"(neuroblast migration)|go:"GO:1901987"(regulation of cell cycle phase transition)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1990086"(lens fiber cell apoptotic process)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR031701|interpro:IPR032949	-	-	-	figure legend:2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/03/31	2014/10/16	rogid:oSo29NrCWIeCi2OMusohCk64uiw7227	rogid:2L0pSyki8qB2GWxiSfs9M1ruwXM10090	intact-crc:D773F6BBCF5441F4|rigid:noQ2wx8NoJUVBieUoxV+wDG6CkU	false	35s radiolabel:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P63002	uniprotkb:Q62233	intact:EBI-646888|uniprotkb:Q06195|ensembl:ENSMUSP00000002518	intact:EBI-2297327|uniprotkb:P70176|uniprotkb:P70177|uniprotkb:Q4QQQ3|ensembl:ENSMUSP00000135312|ensembl:ENSMUSP00000135677	psi-mi:tle5_mouse(display_long)|uniprotkb:Tle5(gene name)|psi-mi:Tle5(display_short)|uniprotkb:Aes(gene name synonym)|uniprotkb:Amino-terminal enhancer of split(gene name synonym)|uniprotkb:Esp1(gene name synonym)|uniprotkb:Grg(gene name synonym)|uniprotkb:Grg-5(gene name synonym)|uniprotkb:Grg5(gene name synonym)|uniprotkb:Groucho-related protein 5(gene name synonym)|uniprotkb:Protein ESP1(gene name synonym)|uniprotkb:Protein GRG(gene name synonym)	psi-mi:six3_mouse(display_long)|uniprotkb:Six3(gene name)|psi-mi:Six3(display_short)|uniprotkb:Sine oculis homeobox homolog 3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhu et al. (2002)	pubmed:12050133|imex:IM-20286	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2297966|imex:IM-20286-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034477.1|ensembl:ENSMUSG00000054452(gene)|ensembl:ENSMUST00000002518(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0040008"(regulation of growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000210"(positive regulation of anoikis)|interpro:IPR005617(Groucho/TLE, N-terminal Q-rich region)|interpro:IPR009146(Groucho/transducin-like enhancer)|mint:P63002	refseq:NP_035511.2|dip:DIP-46499N|ensembl:ENSMUSG00000038805(gene)|ensembl:ENSMUST00000175898(transcript)|ensembl:ENSMUST00000176081(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001654"(eye development)|go:"GO:0002070"(epithelial cell maturation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003404"(optic vesicle morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007420"(brain development)|go:"GO:0008406"(gonad development)|go:"GO:0009946"(proximal/distal axis specification)|go:"GO:0014016"(neuroblast differentiation)|go:"GO:0021536"(diencephalon development)|go:"GO:0021537"(telencephalon development)|go:"GO:0021797"(forebrain anterior/posterior pattern specification)|go:"GO:0021798"(forebrain dorsal/ventral pattern formation)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030878"(thyroid gland development)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048512"(circadian behavior)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0061074"(regulation of neural retina development)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0097402"(neuroblast migration)|go:"GO:1901987"(regulation of cell cycle phase transition)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1990086"(lens fiber cell apoptotic process)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR031701|interpro:IPR032949	-	-	-	figure legend:3A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/03/31	2014/10/16	rogid:3rMMpP0J+0tEUlSLA/PofvANFjU10090	rogid:2L0pSyki8qB2GWxiSfs9M1ruwXM10090	intact-crc:85730800E2E24960|rigid:y8j+6+0pF9d8npaBSGar4aM6ctw	false	-	sufficient binding region:73-120	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62233	uniprotkb:P63002	intact:EBI-2297327|uniprotkb:P70176|uniprotkb:P70177|uniprotkb:Q4QQQ3|ensembl:ENSMUSP00000135312|ensembl:ENSMUSP00000135677	intact:EBI-646888|uniprotkb:Q06195|ensembl:ENSMUSP00000002518	psi-mi:six3_mouse(display_long)|uniprotkb:Six3(gene name)|psi-mi:Six3(display_short)|uniprotkb:Sine oculis homeobox homolog 3(gene name synonym)	psi-mi:tle5_mouse(display_long)|uniprotkb:Tle5(gene name)|psi-mi:Tle5(display_short)|uniprotkb:Aes(gene name synonym)|uniprotkb:Amino-terminal enhancer of split(gene name synonym)|uniprotkb:Esp1(gene name synonym)|uniprotkb:Grg(gene name synonym)|uniprotkb:Grg-5(gene name synonym)|uniprotkb:Grg5(gene name synonym)|uniprotkb:Groucho-related protein 5(gene name synonym)|uniprotkb:Protein ESP1(gene name synonym)|uniprotkb:Protein GRG(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhu et al. (2002)	pubmed:12050133|imex:IM-20286	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2298004|imex:IM-20286-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035511.2|dip:DIP-46499N|ensembl:ENSMUSG00000038805(gene)|ensembl:ENSMUST00000175898(transcript)|ensembl:ENSMUST00000176081(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001654"(eye development)|go:"GO:0002070"(epithelial cell maturation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003404"(optic vesicle morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007420"(brain development)|go:"GO:0008406"(gonad development)|go:"GO:0009946"(proximal/distal axis specification)|go:"GO:0014016"(neuroblast differentiation)|go:"GO:0021536"(diencephalon development)|go:"GO:0021537"(telencephalon development)|go:"GO:0021797"(forebrain anterior/posterior pattern specification)|go:"GO:0021798"(forebrain dorsal/ventral pattern formation)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030878"(thyroid gland development)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048512"(circadian behavior)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0061074"(regulation of neural retina development)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0097402"(neuroblast migration)|go:"GO:1901987"(regulation of cell cycle phase transition)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1990086"(lens fiber cell apoptotic process)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR031701|interpro:IPR032949	refseq:NP_034477.1|ensembl:ENSMUSG00000054452(gene)|ensembl:ENSMUST00000002518(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0040008"(regulation of growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000210"(positive regulation of anoikis)|interpro:IPR005617(Groucho/TLE, N-terminal Q-rich region)|interpro:IPR009146(Groucho/transducin-like enhancer)|mint:P63002	-	-	-	figure legend:3B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/03/31	2014/10/16	rogid:2L0pSyki8qB2GWxiSfs9M1ruwXM10090	rogid:3rMMpP0J+0tEUlSLA/PofvANFjU10090	intact-crc:C548B9EF33D0C183|rigid:y8j+6+0pF9d8npaBSGar4aM6ctw	false	-	sufficient binding region:1-134(IPR005617)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62233	uniprotkb:P63002	intact:EBI-2297327|uniprotkb:P70176|uniprotkb:P70177|uniprotkb:Q4QQQ3|ensembl:ENSMUSP00000135312|ensembl:ENSMUSP00000135677	intact:EBI-646888|uniprotkb:Q06195|ensembl:ENSMUSP00000002518	psi-mi:six3_mouse(display_long)|uniprotkb:Six3(gene name)|psi-mi:Six3(display_short)|uniprotkb:Sine oculis homeobox homolog 3(gene name synonym)	psi-mi:tle5_mouse(display_long)|uniprotkb:Tle5(gene name)|psi-mi:Tle5(display_short)|uniprotkb:Aes(gene name synonym)|uniprotkb:Amino-terminal enhancer of split(gene name synonym)|uniprotkb:Esp1(gene name synonym)|uniprotkb:Grg(gene name synonym)|uniprotkb:Grg-5(gene name synonym)|uniprotkb:Grg5(gene name synonym)|uniprotkb:Groucho-related protein 5(gene name synonym)|uniprotkb:Protein ESP1(gene name synonym)|uniprotkb:Protein GRG(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Zhu et al. (2002)	pubmed:12050133|imex:IM-20286	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2298020|imex:IM-20286-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035511.2|dip:DIP-46499N|ensembl:ENSMUSG00000038805(gene)|ensembl:ENSMUST00000175898(transcript)|ensembl:ENSMUST00000176081(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001654"(eye development)|go:"GO:0002070"(epithelial cell maturation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003404"(optic vesicle morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007420"(brain development)|go:"GO:0008406"(gonad development)|go:"GO:0009946"(proximal/distal axis specification)|go:"GO:0014016"(neuroblast differentiation)|go:"GO:0021536"(diencephalon development)|go:"GO:0021537"(telencephalon development)|go:"GO:0021797"(forebrain anterior/posterior pattern specification)|go:"GO:0021798"(forebrain dorsal/ventral pattern formation)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030878"(thyroid gland development)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048512"(circadian behavior)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0061074"(regulation of neural retina development)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0097402"(neuroblast migration)|go:"GO:1901987"(regulation of cell cycle phase transition)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1990086"(lens fiber cell apoptotic process)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR031701|interpro:IPR032949	refseq:NP_034477.1|ensembl:ENSMUSG00000054452(gene)|ensembl:ENSMUST00000002518(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0040008"(regulation of growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000210"(positive regulation of anoikis)|interpro:IPR005617(Groucho/TLE, N-terminal Q-rich region)|interpro:IPR009146(Groucho/transducin-like enhancer)|mint:P63002	go:"GO:0005634"(nucleus)	-	-	figure legend:4B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-3t3)|taxid:10090(Mus musculus embryo cells)	-	2009/03/31	2014/10/16	rogid:2L0pSyki8qB2GWxiSfs9M1ruwXM10090	rogid:3rMMpP0J+0tEUlSLA/PofvANFjU10090	intact-crc:046202ABF2F2FE3E|rigid:y8j+6+0pF9d8npaBSGar4aM6ctw	false	-	flag tag:?-?	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q62233	uniprotkb:Q62441	intact:EBI-2297327|uniprotkb:P70176|uniprotkb:P70177|uniprotkb:Q4QQQ3|ensembl:ENSMUSP00000135312|ensembl:ENSMUSP00000135677	intact:EBI-2297871|uniprotkb:Q9JKQ9|ensembl:ENSMUSP00000057527	psi-mi:six3_mouse(display_long)|uniprotkb:Six3(gene name)|psi-mi:Six3(display_short)|uniprotkb:Sine oculis homeobox homolog 3(gene name synonym)	psi-mi:tle4_mouse(display_long)|uniprotkb:Tle4(gene name)|psi-mi:Tle4(display_short)|uniprotkb:Grg4(gene name synonym)|uniprotkb:Groucho-related protein 4(gene name synonym)|uniprotkb:Grg-4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhu et al. (2002)	pubmed:12050133|imex:IM-20286	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2298051|imex:IM-20286-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035511.2|dip:DIP-46499N|ensembl:ENSMUSG00000038805(gene)|ensembl:ENSMUST00000175898(transcript)|ensembl:ENSMUST00000176081(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001654"(eye development)|go:"GO:0002070"(epithelial cell maturation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003404"(optic vesicle morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007420"(brain development)|go:"GO:0008406"(gonad development)|go:"GO:0009946"(proximal/distal axis specification)|go:"GO:0014016"(neuroblast differentiation)|go:"GO:0021536"(diencephalon development)|go:"GO:0021537"(telencephalon development)|go:"GO:0021797"(forebrain anterior/posterior pattern specification)|go:"GO:0021798"(forebrain dorsal/ventral pattern formation)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030878"(thyroid gland development)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048512"(circadian behavior)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0061074"(regulation of neural retina development)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0097402"(neuroblast migration)|go:"GO:1901987"(regulation of cell cycle phase transition)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1990086"(lens fiber cell apoptotic process)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR031701|interpro:IPR032949	refseq:NP_035730.2|ensembl:ENSMUSG00000024642(gene)|ensembl:ENSMUST00000052011(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR005617(Groucho/TLE, N-terminal Q-rich region)|interpro:IPR009146(Groucho/transducin-like enhancer)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|reactome:R-MMU-201722|reactome:R-MMU-3769402|reactome:R-MMU-4641265	-	-	-	figure legend:2C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-3t3)|taxid:10090(Mus musculus embryo cells)	-	2009/03/31	2014/10/16	rogid:2L0pSyki8qB2GWxiSfs9M1ruwXM10090	rogid:xNGIMU4i7uY1bzWCV79+KsY+zW010090	intact-crc:33C82C576A3B48F5|rigid:WfBmVBipjPIY1xdhIcLm2VP7TZA	false	-	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q62233	uniprotkb:P16371	intact:EBI-2297327|uniprotkb:P70176|uniprotkb:P70177|uniprotkb:Q4QQQ3|ensembl:ENSMUSP00000135312|ensembl:ENSMUSP00000135677	intact:EBI-153866|intact:EBI-1639108|uniprotkb:Q0KI08|uniprotkb:Q7KRZ4|uniprotkb:Q9V3F7|uniprotkb:A4V3F6|ensemblmetazoa:FBpp0089115	psi-mi:six3_mouse(display_long)|uniprotkb:Six3(gene name)|psi-mi:Six3(display_short)|uniprotkb:Sine oculis homeobox homolog 3(gene name synonym)	psi-mi:grou_drome(display_long)|uniprotkb:gro(gene name)|psi-mi:gro(display_short)|uniprotkb:"E(spl)m9/m10"(gene name synonym)|uniprotkb:CG8384(orf name)|uniprotkb:Enhancer of split m9/10 protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zhu et al. (2002)	pubmed:12050133|imex:IM-20286	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2298058|imex:IM-20286-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035511.2|dip:DIP-46499N|ensembl:ENSMUSG00000038805(gene)|ensembl:ENSMUST00000175898(transcript)|ensembl:ENSMUST00000176081(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001654"(eye development)|go:"GO:0002070"(epithelial cell maturation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003404"(optic vesicle morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007420"(brain development)|go:"GO:0008406"(gonad development)|go:"GO:0009946"(proximal/distal axis specification)|go:"GO:0014016"(neuroblast differentiation)|go:"GO:0021536"(diencephalon development)|go:"GO:0021537"(telencephalon development)|go:"GO:0021797"(forebrain anterior/posterior pattern specification)|go:"GO:0021798"(forebrain dorsal/ventral pattern formation)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030878"(thyroid gland development)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048512"(circadian behavior)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0061074"(regulation of neural retina development)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0097402"(neuroblast migration)|go:"GO:1901987"(regulation of cell cycle phase transition)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1990086"(lens fiber cell apoptotic process)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR031701|interpro:IPR032949	refseq:NP_001189293.1|refseq:NP_524514.2|refseq:NP_733133.1|refseq:NP_733134.1|refseq:NP_733135.1|refseq:NP_996298.1|flybase:FBgn0001139|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0071837"(HMG box domain binding)|go:"GO:0071906"(CRD domain binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR005617(Groucho/TLE, N-terminal Q-rich region)|interpro:IPR009146(Groucho/transducin-like enhancer)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|mint:P16371|reactome:R-DME-201722|reactome:R-DME-209421|reactome:R-DME-209441|reactome:R-DME-3769402|reactome:R-DME-4641265|go:"GO:0045751"(negative regulation of Toll signaling pathway)|ensemblmetazoa:FBgn0001139(gene)|ensemblmetazoa:FBtr0084966(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007541"("sex determination, primary response to X:A ratio")|go:"GO:0008134"(transcription factor binding)|go:"GO:0008293"(torso signaling pathway)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0032991"(protein-containing complex)|dip:DIP-40N	-	-	-	figure legend:2D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-3t3)|taxid:10090(Mus musculus embryo cells)	-	2009/03/31	2014/10/16	rogid:2L0pSyki8qB2GWxiSfs9M1ruwXM10090	rogid:oSo29NrCWIeCi2OMusohCk64uiw7227	intact-crc:E89EE6BB114D0A59|rigid:noQ2wx8NoJUVBieUoxV+wDG6CkU	false	-	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)