#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P14222	uniprotkb:P10124	intact:EBI-724466|uniprotkb:Q59F57|uniprotkb:Q86WX7|ensembl:ENSP00000362305|ensembl:ENSP00000398568|uniprotkb:B2R6X4	intact:EBI-744915|uniprotkb:Q5VW06|uniprotkb:B2R4L7|ensembl:ENSP00000242465	psi-mi:perf_human(display_long)|uniprotkb:Lymphocyte pore-forming protein(gene name synonym)|uniprotkb:Cytolysin(gene name synonym)|uniprotkb:PRF1(gene name)|psi-mi:PRF1(display_short)|uniprotkb:PFP(gene name synonym)	psi-mi:srgn_human(display_long)|uniprotkb:Secretory granule proteoglycan core protein(gene name synonym)|uniprotkb:Platelet proteoglycan core protein(gene name synonym)|uniprotkb:SRGN(gene name)|psi-mi:SRGN(display_short)|uniprotkb:PRG(gene name synonym)|uniprotkb:PRG1(gene name synonym)|uniprotkb:Hematopoietic proteoglycan core protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Metkar et al. (2002)	pubmed:11911826|imex:IM-20405	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2504915|imex:IM-20405-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001076585.1|refseq:NP_005032.2|ensembl:ENSG00000180644(gene)|ensembl:ENST00000373209(transcript)|ensembl:ENST00000441259(transcript)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001913"(T cell mediated cytotoxicity)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0002418"(immune response to tumor cell)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019835"(cytolysis)|go:"GO:0022829"(wide pore channel activity)|go:"GO:0031904"(endosome lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0044194"(cytolytic granule)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0051712"(positive regulation of killing of cells of another organism)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR020863|interpro:IPR020864|interpro:IPR035892|interpro:IPR037300|go:"GO:0006915"(apoptotic process)|dip:DIP-53288N	refseq:NP_002718.2|go:"GO:0042629"(mast cell granule)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|interpro:IPR007455(Serglycin)|mint:P10124|reactome:R-HSA-114608|ensembl:ENSG00000122862(gene)|ensembl:ENST00000242465(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006915"(apoptotic process)|go:"GO:0016485"(protein processing)|go:"GO:0030141"(secretory granule)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0033363"(secretory granule organization)|go:"GO:0033364"(mast cell secretory granule organization)|go:"GO:0033371"(T cell secretory granule organization)|go:"GO:0033373"(maintenance of protease location in mast cell secretory granule)|go:"GO:0033382"(maintenance of granzyme B location in T cell secretory granule)|refseq:NP_001307982.1|refseq:NP_001307983.1|refseq:XP_016871881.1	go:"GO:0044194"(cytolytic granule)	-	-	figure legend:Fig. 2A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-yt)|taxid:9606(Homo sapiens)	-	2009/12/02	2014/10/16	rogid:EEm2Iq36E4D5zMJPDWzBXZi1KcY9606	rogid:fc8Rv0C285T5/uBa6eAVR4lvW3s9606	intact-crc:73277E43D741F782|rigid:XabV2oKEXWxPyC/QtLBhwjqPPsg	false	35s radiolabel:?-?	35s radiolabel:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P10124	uniprotkb:P10144	intact:EBI-744915|uniprotkb:Q5VW06|uniprotkb:B2R4L7|ensembl:ENSP00000242465	intact:EBI-2505785|ensembl:ENSP00000216341|uniprotkb:Q8N1D2|uniprotkb:Q9UCC1	psi-mi:srgn_human(display_long)|uniprotkb:Secretory granule proteoglycan core protein(gene name synonym)|uniprotkb:Platelet proteoglycan core protein(gene name synonym)|uniprotkb:SRGN(gene name)|psi-mi:SRGN(display_short)|uniprotkb:PRG(gene name synonym)|uniprotkb:PRG1(gene name synonym)|uniprotkb:Hematopoietic proteoglycan core protein(gene name synonym)	psi-mi:grab_human(display_long)|uniprotkb:GZMB(gene name)|psi-mi:GZMB(display_short)|uniprotkb:CGL1(gene name synonym)|uniprotkb:CSPB(gene name synonym)|uniprotkb:CTLA1(gene name synonym)|uniprotkb:GRB(gene name synonym)|uniprotkb:Granzyme-2(gene name synonym)|uniprotkb:T-cell serine protease 1-3E(gene name synonym)|uniprotkb:Cytotoxic T-lymphocyte proteinase 2(gene name synonym)|uniprotkb:SECT(gene name synonym)|uniprotkb:Cathepsin G-like 1(gene name synonym)|uniprotkb:CTLA-1(gene name synonym)|uniprotkb:Fragmentin-2(gene name synonym)|uniprotkb:Human lymphocyte protein(gene name synonym)|uniprotkb:C11(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Metkar et al. (2002)	pubmed:11911826|imex:IM-20405	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2505820|imex:IM-20405-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002718.2|go:"GO:0042629"(mast cell granule)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|interpro:IPR007455(Serglycin)|mint:P10124|reactome:R-HSA-114608|ensembl:ENSG00000122862(gene)|ensembl:ENST00000242465(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006915"(apoptotic process)|go:"GO:0016485"(protein processing)|go:"GO:0030141"(secretory granule)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0033363"(secretory granule organization)|go:"GO:0033364"(mast cell secretory granule organization)|go:"GO:0033371"(T cell secretory granule organization)|go:"GO:0033373"(maintenance of protease location in mast cell secretory granule)|go:"GO:0033382"(maintenance of granzyme B location in T cell secretory granule)|refseq:NP_001307982.1|refseq:NP_001307983.1|refseq:XP_016871881.1	ensembl:ENSG00000100453(gene)|ensembl:ENST00000216341(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019835"(cytolysis)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044194"(cytolytic granule)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0070269"(pyroptosis)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|go:"GO:1900740"(positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|mint:P10144|rcsb pdb:1FQ3|rcsb pdb:1IAU|reactome:R-HSA-2197563|reactome:R-HSA-5620971|reactome:R-HSA-75108|refseq:NP_004122.2	go:"GO:0044194"(cytolytic granule)	-	-	figure legend:Fig. 2A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-yt)|taxid:9606(Homo sapiens)	-	2009/12/02	2014/10/16	rogid:fc8Rv0C285T5/uBa6eAVR4lvW3s9606	rogid:LyVQovcoKi8uNg/tzR4x0051nII9606	intact-crc:D093801601818863|rigid:rRuWOyDRecPL5NO4zoS2T1m9CiQ	false	35s radiolabel:?-?	35s radiolabel:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P14222	uniprotkb:P10144	intact:EBI-724466|uniprotkb:Q59F57|uniprotkb:Q86WX7|ensembl:ENSP00000362305|ensembl:ENSP00000398568|uniprotkb:B2R6X4	intact:EBI-2505785|ensembl:ENSP00000216341|uniprotkb:Q8N1D2|uniprotkb:Q9UCC1	psi-mi:perf_human(display_long)|uniprotkb:Lymphocyte pore-forming protein(gene name synonym)|uniprotkb:Cytolysin(gene name synonym)|uniprotkb:PRF1(gene name)|psi-mi:PRF1(display_short)|uniprotkb:PFP(gene name synonym)	psi-mi:grab_human(display_long)|uniprotkb:GZMB(gene name)|psi-mi:GZMB(display_short)|uniprotkb:CGL1(gene name synonym)|uniprotkb:CSPB(gene name synonym)|uniprotkb:CTLA1(gene name synonym)|uniprotkb:GRB(gene name synonym)|uniprotkb:Granzyme-2(gene name synonym)|uniprotkb:T-cell serine protease 1-3E(gene name synonym)|uniprotkb:Cytotoxic T-lymphocyte proteinase 2(gene name synonym)|uniprotkb:SECT(gene name synonym)|uniprotkb:Cathepsin G-like 1(gene name synonym)|uniprotkb:CTLA-1(gene name synonym)|uniprotkb:Fragmentin-2(gene name synonym)|uniprotkb:Human lymphocyte protein(gene name synonym)|uniprotkb:C11(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Metkar et al. (2002)	pubmed:11911826|imex:IM-20405	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2505832|imex:IM-20405-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001076585.1|refseq:NP_005032.2|ensembl:ENSG00000180644(gene)|ensembl:ENST00000373209(transcript)|ensembl:ENST00000441259(transcript)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001913"(T cell mediated cytotoxicity)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0002418"(immune response to tumor cell)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019835"(cytolysis)|go:"GO:0022829"(wide pore channel activity)|go:"GO:0031904"(endosome lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0044194"(cytolytic granule)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0051712"(positive regulation of killing of cells of another organism)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR020863|interpro:IPR020864|interpro:IPR035892|interpro:IPR037300|go:"GO:0006915"(apoptotic process)|dip:DIP-53288N	ensembl:ENSG00000100453(gene)|ensembl:ENST00000216341(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019835"(cytolysis)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044194"(cytolytic granule)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0070269"(pyroptosis)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|go:"GO:1900740"(positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|mint:P10144|rcsb pdb:1FQ3|rcsb pdb:1IAU|reactome:R-HSA-2197563|reactome:R-HSA-5620971|reactome:R-HSA-75108|refseq:NP_004122.2	go:"GO:0044194"(cytolytic granule)	-	-	comment:This perf-grab complex was shown to bind to sulfated proteoglycans or glycosaminoglycans in a Biocolor Ltd. Blyscan assay, which the authors present as evidence for binding to SRGN.|figure legend:Fig. 2D.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-yt)|taxid:9606(Homo sapiens)	-	2009/12/02	2014/10/16	rogid:EEm2Iq36E4D5zMJPDWzBXZi1KcY9606	rogid:LyVQovcoKi8uNg/tzR4x0051nII9606	intact-crc:2D3BFBD0F4BEEE6F|rigid:Dzs0cSSY+txqKfCp6qsbfPYNpHo	false	35s radiolabel:?-?	35s radiolabel:?-?	-	-	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)
uniprotkb:P10144	uniprotkb:P10124	intact:EBI-2505785|ensembl:ENSP00000216341|uniprotkb:Q8N1D2|uniprotkb:Q9UCC1	intact:EBI-744915|uniprotkb:Q5VW06|uniprotkb:B2R4L7|ensembl:ENSP00000242465	psi-mi:grab_human(display_long)|uniprotkb:GZMB(gene name)|psi-mi:GZMB(display_short)|uniprotkb:CGL1(gene name synonym)|uniprotkb:CSPB(gene name synonym)|uniprotkb:CTLA1(gene name synonym)|uniprotkb:GRB(gene name synonym)|uniprotkb:Granzyme-2(gene name synonym)|uniprotkb:T-cell serine protease 1-3E(gene name synonym)|uniprotkb:Cytotoxic T-lymphocyte proteinase 2(gene name synonym)|uniprotkb:SECT(gene name synonym)|uniprotkb:Cathepsin G-like 1(gene name synonym)|uniprotkb:CTLA-1(gene name synonym)|uniprotkb:Fragmentin-2(gene name synonym)|uniprotkb:Human lymphocyte protein(gene name synonym)|uniprotkb:C11(gene name synonym)	psi-mi:srgn_human(display_long)|uniprotkb:Secretory granule proteoglycan core protein(gene name synonym)|uniprotkb:Platelet proteoglycan core protein(gene name synonym)|uniprotkb:SRGN(gene name)|psi-mi:SRGN(display_short)|uniprotkb:PRG(gene name synonym)|uniprotkb:PRG1(gene name synonym)|uniprotkb:Hematopoietic proteoglycan core protein(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Metkar et al. (2002)	pubmed:11911826|imex:IM-20405	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2505849|imex:IM-20405-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000100453(gene)|ensembl:ENST00000216341(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019835"(cytolysis)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044194"(cytolytic granule)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0070269"(pyroptosis)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|go:"GO:1900740"(positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|mint:P10144|rcsb pdb:1FQ3|rcsb pdb:1IAU|reactome:R-HSA-2197563|reactome:R-HSA-5620971|reactome:R-HSA-75108|refseq:NP_004122.2	refseq:NP_002718.2|go:"GO:0042629"(mast cell granule)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|interpro:IPR007455(Serglycin)|mint:P10124|reactome:R-HSA-114608|ensembl:ENSG00000122862(gene)|ensembl:ENST00000242465(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006915"(apoptotic process)|go:"GO:0016485"(protein processing)|go:"GO:0030141"(secretory granule)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0033363"(secretory granule organization)|go:"GO:0033364"(mast cell secretory granule organization)|go:"GO:0033371"(T cell secretory granule organization)|go:"GO:0033373"(maintenance of protease location in mast cell secretory granule)|go:"GO:0033382"(maintenance of granzyme B location in T cell secretory granule)|refseq:NP_001307982.1|refseq:NP_001307983.1|refseq:XP_016871881.1	go:"GO:0044194"(cytolytic granule)	-	-	figure legend:Fig. 4B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/12/02	2014/10/16	rogid:LyVQovcoKi8uNg/tzR4x0051nII9606	rogid:fc8Rv0C285T5/uBa6eAVR4lvW3s9606	intact-crc:39B9CECDB8C02EB8|rigid:rRuWOyDRecPL5NO4zoS2T1m9CiQ	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P10144	uniprotkb:P14222	intact:EBI-2505785|ensembl:ENSP00000216341|uniprotkb:Q8N1D2|uniprotkb:Q9UCC1	intact:EBI-724466|uniprotkb:Q59F57|uniprotkb:Q86WX7|ensembl:ENSP00000362305|ensembl:ENSP00000398568|uniprotkb:B2R6X4	psi-mi:grab_human(display_long)|uniprotkb:GZMB(gene name)|psi-mi:GZMB(display_short)|uniprotkb:CGL1(gene name synonym)|uniprotkb:CSPB(gene name synonym)|uniprotkb:CTLA1(gene name synonym)|uniprotkb:GRB(gene name synonym)|uniprotkb:Granzyme-2(gene name synonym)|uniprotkb:T-cell serine protease 1-3E(gene name synonym)|uniprotkb:Cytotoxic T-lymphocyte proteinase 2(gene name synonym)|uniprotkb:SECT(gene name synonym)|uniprotkb:Cathepsin G-like 1(gene name synonym)|uniprotkb:CTLA-1(gene name synonym)|uniprotkb:Fragmentin-2(gene name synonym)|uniprotkb:Human lymphocyte protein(gene name synonym)|uniprotkb:C11(gene name synonym)	psi-mi:perf_human(display_long)|uniprotkb:Lymphocyte pore-forming protein(gene name synonym)|uniprotkb:Cytolysin(gene name synonym)|uniprotkb:PRF1(gene name)|psi-mi:PRF1(display_short)|uniprotkb:PFP(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Metkar et al. (2002)	pubmed:11911826|imex:IM-20405	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2506268|imex:IM-20405-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000100453(gene)|ensembl:ENST00000216341(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019835"(cytolysis)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044194"(cytolytic granule)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0070269"(pyroptosis)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|go:"GO:1900740"(positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|mint:P10144|rcsb pdb:1FQ3|rcsb pdb:1IAU|reactome:R-HSA-2197563|reactome:R-HSA-5620971|reactome:R-HSA-75108|refseq:NP_004122.2	refseq:NP_001076585.1|refseq:NP_005032.2|ensembl:ENSG00000180644(gene)|ensembl:ENST00000373209(transcript)|ensembl:ENST00000441259(transcript)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001913"(T cell mediated cytotoxicity)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0002418"(immune response to tumor cell)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019835"(cytolysis)|go:"GO:0022829"(wide pore channel activity)|go:"GO:0031904"(endosome lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0044194"(cytolytic granule)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0051712"(positive regulation of killing of cells of another organism)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR020863|interpro:IPR020864|interpro:IPR035892|interpro:IPR037300|go:"GO:0006915"(apoptotic process)|dip:DIP-53288N	-	-	-	figure legend:Fig. 2B.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-yt)|taxid:9606(Homo sapiens)	-	2009/12/02	2014/10/16	rogid:LyVQovcoKi8uNg/tzR4x0051nII9606	rogid:EEm2Iq36E4D5zMJPDWzBXZi1KcY9606	intact-crc:76E5271AEB715A7A|rigid:Dzs0cSSY+txqKfCp6qsbfPYNpHo	false	35s radiolabel:?-?	35s radiolabel:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P10144	uniprotkb:P14222	intact:EBI-2505785|ensembl:ENSP00000216341|uniprotkb:Q8N1D2|uniprotkb:Q9UCC1	intact:EBI-724466|uniprotkb:Q59F57|uniprotkb:Q86WX7|ensembl:ENSP00000362305|ensembl:ENSP00000398568|uniprotkb:B2R6X4	psi-mi:grab_human(display_long)|uniprotkb:GZMB(gene name)|psi-mi:GZMB(display_short)|uniprotkb:CGL1(gene name synonym)|uniprotkb:CSPB(gene name synonym)|uniprotkb:CTLA1(gene name synonym)|uniprotkb:GRB(gene name synonym)|uniprotkb:Granzyme-2(gene name synonym)|uniprotkb:T-cell serine protease 1-3E(gene name synonym)|uniprotkb:Cytotoxic T-lymphocyte proteinase 2(gene name synonym)|uniprotkb:SECT(gene name synonym)|uniprotkb:Cathepsin G-like 1(gene name synonym)|uniprotkb:CTLA-1(gene name synonym)|uniprotkb:Fragmentin-2(gene name synonym)|uniprotkb:Human lymphocyte protein(gene name synonym)|uniprotkb:C11(gene name synonym)	psi-mi:perf_human(display_long)|uniprotkb:Lymphocyte pore-forming protein(gene name synonym)|uniprotkb:Cytolysin(gene name synonym)|uniprotkb:PRF1(gene name)|psi-mi:PRF1(display_short)|uniprotkb:PFP(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Metkar et al. (2002)	pubmed:11911826|imex:IM-20405	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2506276|imex:IM-20405-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000100453(gene)|ensembl:ENST00000216341(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019835"(cytolysis)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044194"(cytolytic granule)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0070269"(pyroptosis)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|go:"GO:1900740"(positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|mint:P10144|rcsb pdb:1FQ3|rcsb pdb:1IAU|reactome:R-HSA-2197563|reactome:R-HSA-5620971|reactome:R-HSA-75108|refseq:NP_004122.2	refseq:NP_001076585.1|refseq:NP_005032.2|ensembl:ENSG00000180644(gene)|ensembl:ENST00000373209(transcript)|ensembl:ENST00000441259(transcript)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001913"(T cell mediated cytotoxicity)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0002418"(immune response to tumor cell)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019835"(cytolysis)|go:"GO:0022829"(wide pore channel activity)|go:"GO:0031904"(endosome lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0044194"(cytolytic granule)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0051712"(positive regulation of killing of cells of another organism)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR020863|interpro:IPR020864|interpro:IPR035892|interpro:IPR037300|go:"GO:0006915"(apoptotic process)|dip:DIP-53288N	-	-	-	figure legend:Fig. 2C.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-yt)|taxid:9606(Homo sapiens)	-	2009/12/02	2014/10/16	rogid:LyVQovcoKi8uNg/tzR4x0051nII9606	rogid:EEm2Iq36E4D5zMJPDWzBXZi1KcY9606	intact-crc:7C4F8C0041D9ACAC|rigid:Dzs0cSSY+txqKfCp6qsbfPYNpHo	false	35s radiolabel:?-?	35s radiolabel:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)