#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P97814	uniprotkb:P35831	intact:EBI-7484574|uniprotkb:Q4V9R4|intact:MINT-444743	intact:EBI-2642957|uniprotkb:Q80UM4|ensembl:ENSMUSP00000030556	psi-mi:ppip1_mouse(display_long)|uniprotkb:Pstpip1(gene name)|psi-mi:Pstpip1(display_short)	psi-mi:ptn12_mouse(display_long)|uniprotkb:Protein-tyrosine phosphatase P19(gene name synonym)|uniprotkb:Ptpn12(gene name)|psi-mi:Ptpn12(display_short)|uniprotkb:MPTP-PEST(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Côté et al. (2002)	pubmed:11711533|mint:MINT-6671484	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8038191|mint:MINT-7014985	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR027267|mint:P97814|interpro:IPR031160|interpro:IPR036028|refseq:NP_035323.2|interpro:IPR030777|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|go:"GO:0001725"(stress fiber)|go:"GO:0001931"(uropod)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005826"(actomyosin contractile ring)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0032154"(cleavage furrow)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|reactome:R-MMU-844456|mint:MINT-7014987(identity)	refseq:NP_035333.2|ensembl:ENSMUSG00000028771(gene)|ensembl:ENSMUST00000030556(transcript)|go:"GO:0002102"(podosome)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042995"(cell projection)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012266(Protein-tyrosine phosphatase, non-receptor type-12)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|mint:P35831|reactome:R-MMU-1250196|reactome:R-MMU-182971|reactome:R-MMU-186797|reactome:R-MMU-8863795|mint:MINT-7014988(identity)	-	comment:mint|comment:homomint|function:"Involved in regulation of the actin cytoskeleton. May regulate the WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to the ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS, and allows PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymeriszation required for synapse induction during T-cell activation. Down-regulates CD2-stimulated adhesion through coupling PTPN12 to CD2"	-	figure legend:F2B|comment:homomint|comment:domino|comment:mint	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2009/03/31	2014/10/16	rogid:rC2GOU2BlaFNkA4+iB9pAYHJBDI10090	rogid:GgHiRVbQuJTf7k7PeNejGiKHybQ10090	intact-crc:A102B6BE5F094AFA|rigid:BKpAS4EcEwTOfHRffBdcYNxkbB8	false	-	binding-associated region:119-539(MINT-7015188)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P97814	uniprotkb:P35831	intact:EBI-7484574|uniprotkb:Q4V9R4|intact:MINT-444743	intact:EBI-2642957|uniprotkb:Q80UM4|ensembl:ENSMUSP00000030556	psi-mi:ppip1_mouse(display_long)|uniprotkb:Pstpip1(gene name)|psi-mi:Pstpip1(display_short)	psi-mi:ptn12_mouse(display_long)|uniprotkb:Protein-tyrosine phosphatase P19(gene name synonym)|uniprotkb:Ptpn12(gene name)|psi-mi:Ptpn12(display_short)|uniprotkb:MPTP-PEST(gene name synonym)	psi-mi:"MI:0096"(pull down)	Côté et al. (2002)	pubmed:11711533|mint:MINT-6671484	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8038221|mint:MINT-7015204	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR027267|mint:P97814|interpro:IPR031160|interpro:IPR036028|refseq:NP_035323.2|interpro:IPR030777|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|go:"GO:0001725"(stress fiber)|go:"GO:0001931"(uropod)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005826"(actomyosin contractile ring)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0032154"(cleavage furrow)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|reactome:R-MMU-844456|mint:MINT-7015211(identity)	refseq:NP_035333.2|ensembl:ENSMUSG00000028771(gene)|ensembl:ENSMUST00000030556(transcript)|go:"GO:0002102"(podosome)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042995"(cell projection)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012266(Protein-tyrosine phosphatase, non-receptor type-12)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|mint:P35831|reactome:R-MMU-1250196|reactome:R-MMU-182971|reactome:R-MMU-186797|reactome:R-MMU-8863795|mint:MINT-7015206(identity)	-	comment:mint|comment:homomint|function:"Involved in regulation of the actin cytoskeleton. May regulate the WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to the ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS, and allows PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymeriszation required for synapse induction during T-cell activation. Down-regulates CD2-stimulated adhesion through coupling PTPN12 to CD2"	-	figure legend:F2C|comment:homomint|comment:domino|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/03/31	2014/10/16	rogid:rC2GOU2BlaFNkA4+iB9pAYHJBDI10090	rogid:GgHiRVbQuJTf7k7PeNejGiKHybQ10090	intact-crc:5A2733ED349668BF|rigid:BKpAS4EcEwTOfHRffBdcYNxkbB8	false	-	glutathione s tranferase tag:?-?(MINT-7015229)|binding-associated region:119-539(MINT-7015207)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P97814	uniprotkb:P35831	intact:EBI-7484574|uniprotkb:Q4V9R4|intact:MINT-444743	intact:EBI-2642957|uniprotkb:Q80UM4|ensembl:ENSMUSP00000030556	psi-mi:ppip1_mouse(display_long)|uniprotkb:Pstpip1(gene name)|psi-mi:Pstpip1(display_short)	psi-mi:ptn12_mouse(display_long)|uniprotkb:Protein-tyrosine phosphatase P19(gene name synonym)|uniprotkb:Ptpn12(gene name)|psi-mi:Ptpn12(display_short)|uniprotkb:MPTP-PEST(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Côté et al. (2002)	pubmed:11711533|mint:MINT-6671484	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0203"(dephosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8038254|mint:MINT-7015235	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR027267|mint:P97814|interpro:IPR031160|interpro:IPR036028|refseq:NP_035323.2|interpro:IPR030777|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|go:"GO:0001725"(stress fiber)|go:"GO:0001931"(uropod)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005826"(actomyosin contractile ring)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0032154"(cleavage furrow)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|reactome:R-MMU-844456|mint:MINT-7015237(identity)	refseq:NP_035333.2|ensembl:ENSMUSG00000028771(gene)|ensembl:ENSMUST00000030556(transcript)|go:"GO:0002102"(podosome)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042995"(cell projection)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012266(Protein-tyrosine phosphatase, non-receptor type-12)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|mint:P35831|reactome:R-MMU-1250196|reactome:R-MMU-182971|reactome:R-MMU-186797|reactome:R-MMU-8863795|mint:MINT-7015239(identity)	-	comment:mint|comment:homomint|function:"Involved in regulation of the actin cytoskeleton. May regulate the WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to the ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS, and allows PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymeriszation required for synapse induction during T-cell activation. Down-regulates CD2-stimulated adhesion through coupling PTPN12 to CD2"	-	figure legend:F5b|comment:homomint|comment:domino|comment:mint	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2009/03/31	2014/10/16	rogid:rC2GOU2BlaFNkA4+iB9pAYHJBDI10090	rogid:GgHiRVbQuJTf7k7PeNejGiKHybQ10090	intact-crc:7E372399643D6CA6|rigid:BKpAS4EcEwTOfHRffBdcYNxkbB8	false	mutation disrupting interaction:344-344(MINT-7015464)	mutation decreasing interaction:231-231(MINT-7015444)|binding-associated region:119-539(MINT-7015242)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P97814	uniprotkb:P35831	intact:EBI-7484574|uniprotkb:Q4V9R4|intact:MINT-444743	intact:EBI-2642957|uniprotkb:Q80UM4|ensembl:ENSMUSP00000030556	psi-mi:ppip1_mouse(display_long)|uniprotkb:Pstpip1(gene name)|psi-mi:Pstpip1(display_short)	psi-mi:ptn12_mouse(display_long)|uniprotkb:Protein-tyrosine phosphatase P19(gene name synonym)|uniprotkb:Ptpn12(gene name)|psi-mi:Ptpn12(display_short)|uniprotkb:MPTP-PEST(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Côté et al. (2002)	pubmed:11711533|mint:MINT-6671484	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-8038298|mint:MINT-7015377	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR027267|mint:P97814|interpro:IPR031160|interpro:IPR036028|refseq:NP_035323.2|interpro:IPR030777|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|go:"GO:0001725"(stress fiber)|go:"GO:0001931"(uropod)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005826"(actomyosin contractile ring)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0032154"(cleavage furrow)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|reactome:R-MMU-844456|mint:MINT-7015385(identity)	refseq:NP_035333.2|ensembl:ENSMUSG00000028771(gene)|ensembl:ENSMUST00000030556(transcript)|go:"GO:0002102"(podosome)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042995"(cell projection)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012266(Protein-tyrosine phosphatase, non-receptor type-12)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|mint:P35831|reactome:R-MMU-1250196|reactome:R-MMU-182971|reactome:R-MMU-186797|reactome:R-MMU-8863795|mint:MINT-7015380(identity)	go:"GO:0048471"(perinuclear region of cytoplasm)	comment:mint|comment:homomint|function:"Involved in regulation of the actin cytoskeleton. May regulate the WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to the ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS, and allows PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymeriszation required for synapse induction during T-cell activation. Down-regulates CD2-stimulated adhesion through coupling PTPN12 to CD2"	-	figure legend:F3A|comment:homomint|comment:domino|comment:mint	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2009/03/31	2014/10/16	rogid:rC2GOU2BlaFNkA4+iB9pAYHJBDI10090	rogid:GgHiRVbQuJTf7k7PeNejGiKHybQ10090	intact-crc:FFF055C0F745B720|rigid:BKpAS4EcEwTOfHRffBdcYNxkbB8	false	green fluorescent protein tag:?-?(MINT-7015386)	binding-associated region:119-539(MINT-7015381)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0422"(immunostaining)