#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q13867	uniprotkb:P05067-4	intact:EBI-718504|uniprotkb:Q53F86|uniprotkb:Q9UER9|uniprotkb:B2R796|ensembl:ENSP00000261714	intact:EBI-302641|ensembl:ENSP00000345463|intact:EBI-8513344|intact:MINT-150885|intact:EBI-8513450|intact:EBI-8513789|intact:EBI-7458081|intact:EBI-7458225|intact:EBI-8513738|intact:EBI-8513677|intact:EBI-8513407|intact:EBI-7457926	psi-mi:blmh_human(display_long)|uniprotkb:BLMH(gene name)|psi-mi:BLMH(display_short)	psi-mi:p05067-4(display_long)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:PreA4 695(isoform synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lefterov et al. (2001)	pubmed:11350084|imex:IM-20356	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2431961|imex:IM-20356-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000377.1|ensembl:ENSG00000108578(gene)|ensembl:ENST00000261714(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0004180"(carboxypeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043418"(homocysteine catabolic process)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR004134(Peptidase C1B, bleomycin hydrolase)|interpro:IPR038765|mint:Q13867|rcsb pdb:1CB5|rcsb pdb:2CB5|reactome:R-HSA-983168	intact:EBI-77613(a4_human)|ensembl:ENSG00000142192(gene)|ensembl:ENST00000348990(transcript)	-	-	isoform-comment:A major isoform.	comment:"No interaction was detected between any of the bleomycin hydrolase constructs and a clone including only the extracellular domain of APP. Additionally no interaction was detected between bleomycin truncation variant (170-455) and full length APP. The authors state that this is consistant with bleomycin hydrolase interacting with the cytoplasmic rather than the extracellular domain of APP."|figure legend:Figure 1|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/09/01	2014/10/16	rogid:THDv63DC81eQzFvmyWs1rlCBMyk9606	rogid:g3lIuSzu8RGEONgITBEVFyMpfqk9606	intact-crc:611B0026F7D96A50|rigid:PVF2yvWpCeLWj6Z2pr39PfpACY0	false	glutathione s tranferase tag:?-?|sufficient binding region:14-82	35s radiolabel:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P05067-4	uniprotkb:Q13867	intact:EBI-302641|ensembl:ENSP00000345463|intact:EBI-8513344|intact:MINT-150885|intact:EBI-8513450|intact:EBI-8513789|intact:EBI-7458081|intact:EBI-7458225|intact:EBI-8513738|intact:EBI-8513677|intact:EBI-8513407|intact:EBI-7457926	intact:EBI-718504|uniprotkb:Q53F86|uniprotkb:Q9UER9|uniprotkb:B2R796|ensembl:ENSP00000261714	psi-mi:p05067-4(display_long)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:PreA4 695(isoform synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:blmh_human(display_long)|uniprotkb:BLMH(gene name)|psi-mi:BLMH(display_short)	psi-mi:"MI:0018"(two hybrid)	Lefterov et al. (2001)	pubmed:11350084|imex:IM-20356	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2432229|imex:IM-20356-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-77613(a4_human)|ensembl:ENSG00000142192(gene)|ensembl:ENST00000348990(transcript)	refseq:NP_000377.1|ensembl:ENSG00000108578(gene)|ensembl:ENST00000261714(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0004180"(carboxypeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043418"(homocysteine catabolic process)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR004134(Peptidase C1B, bleomycin hydrolase)|interpro:IPR038765|mint:Q13867|rcsb pdb:1CB5|rcsb pdb:2CB5|reactome:R-HSA-983168	-	isoform-comment:A major isoform.	-	comment:"The authors note that full length BH was not found among the positive clones examined \"which may be due to inhibition of productive heterologous interactions in the yeast two hybrid environment when BH can oligomerize.\"."|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/09/01	2014/10/16	rogid:g3lIuSzu8RGEONgITBEVFyMpfqk9606	rogid:THDv63DC81eQzFvmyWs1rlCBMyk9606	intact-crc:74C59F365B5982A2|rigid:PVF2yvWpCeLWj6Z2pr39PfpACY0	false	-	sufficient binding region:14-455	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)