#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P05067-PRO_0000000093	uniprotkb:P31696	intact:EBI-2431589|intact:EBI-20772365	intact:EBI-457650|uniprotkb:Q90609|uniprotkb:Q90685	psi-mi:p05067-pro_0000000093(display_long)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:agrin_chick(display_long)|uniprotkb:AGRN(gene name)|psi-mi:AGRN(display_short)|uniprotkb:AGRIN(gene name synonym)	psi-mi:"MI:0027"(cosedimentation)	Cotman et al. (2000)	pubmed:10673326|imex:IM-20352	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2431585|imex:IM-20352-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-77613(chain-parent)	interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003884(Factor I membrane attack complex)|interpro:IPR008993(TIMP-like, OB-fold)|rcsb pdb:1PZ8|rcsb pdb:1PZ9|rcsb pdb:1JB3|rcsb pdb:1JC7|rcsb pdb:1PXU|rcsb pdb:1PZ7|rcsb pdb:1Q56|rcsb pdb:3I70|interpro:IPR004850(Agrin NtA)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR001791(Laminin G)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR000082(SEA)|go:"GO:0043113"(receptor clustering)|go:"GO:0043236"(laminin binding)|go:"GO:0043237"(laminin-1 binding)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045121"(membrane raft)|go:"GO:0045178"(basal part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046847"(filopodium assembly)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098965"(extracellular matrix of synaptic cleft)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008201"(heparin binding)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0030424"(axon)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0033691"(sialic acid binding)|go:"GO:0035374"(chondroitin sulfate binding)|go:"GO:0002162"(dystroglycan binding)|interpro:IPR036058|interpro:IPR036364	-	chain-seq-start:672|chain-seq-end:711	-	figure legend:Fig. 4|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/09/01	2014/10/16	rogid:1Fb4Lc4fYdV85pxpVo7LvPBbD1o9606	rogid:b+RsTdBVRG0NoC+sRNwneIPSA1M9031	intact-crc:53799EF07E49DE66|rigid:KPWEwpRveVt+TcehrMDLvv5SvrM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P05067-PRO_0000000093	uniprotkb:O00468	intact:EBI-2431589|intact:EBI-20772365	intact:EBI-947482|uniprotkb:Q5SVA2|uniprotkb:Q60FE1|uniprotkb:Q7KYS8|uniprotkb:Q8N4J5|uniprotkb:Q96IC1|uniprotkb:Q9BTD4|uniprotkb:Q5SVA1	psi-mi:p05067-pro_0000000093(display_long)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:agrin_human(display_long)|uniprotkb:AGRN(gene name)|psi-mi:AGRN(display_short)|uniprotkb:AGRIN(gene name synonym)	psi-mi:"MI:0426"(light microscopy)	Cotman et al. (2000)	pubmed:10673326|imex:IM-20352	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2431645|imex:IM-20352-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-77613(chain-parent)	refseq:NP_940978.2|interpro:IPR004850(Agrin NtA)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR001791(Laminin G)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR000082(SEA)|interpro:IPR008993(TIMP-like, OB-fold)|refseq:XP_005244806.1|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003884(Factor I membrane attack complex)|mint:O00468|go:"GO:0002162"(dystroglycan binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033691"(sialic acid binding)|go:"GO:0035374"(chondroitin sulfate binding)|go:"GO:0043113"(receptor clustering)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043236"(laminin binding)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045162"(clustering of voltage-gated sodium channels)|go:"GO:0045202"(synapse)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050808"(synapse organization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|reactome:R-HSA-1971475|reactome:R-HSA-2022928|reactome:R-HSA-2024096|reactome:R-HSA-216083|reactome:R-HSA-3000171|reactome:R-HSA-3000178|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3656237|reactome:R-HSA-3656253|reactome:R-HSA-419037|reactome:R-HSA-4420332|reactome:R-HSA-975634|interpro:IPR036058|interpro:IPR036364|refseq:NP_001292204.1	-	chain-seq-start:672|chain-seq-end:711	-	comment:"Immunostaing of Agrin and Abeta (1-40) observed in neuritic plaques in the hippocampus of a 62 year old AD patient."|antibodies:"Human Agrin antibody generated by rabbit immunization with a human agrin fusion protein (amino acids 780-1210) representing the N terminal half of the protein. anti Abeta (1-40) was purchased from Sigma."|figure legend:Fig 6C and D|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2009/09/01	2018/09/18	rogid:1Fb4Lc4fYdV85pxpVo7LvPBbD1o9606	rogid:LRk4v4aYLk5kep9EIbjjiCGM7OM9606	intact-crc:2FDB5DCF90CBB7AC|rigid:/V1yshaJJWYJ8hRz7Q5os9eZ7fo	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P31696	uniprotkb:P05067-PRO_0000000093	intact:EBI-457650|uniprotkb:Q90609|uniprotkb:Q90685	intact:EBI-2431589|intact:EBI-20772365	psi-mi:agrin_chick(display_long)|uniprotkb:AGRN(gene name)|psi-mi:AGRN(display_short)|uniprotkb:AGRIN(gene name synonym)	psi-mi:p05067-pro_0000000093(display_long)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0417"(footprinting)	Cotman et al. (2000)	pubmed:10673326|imex:IM-20352	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2431823|imex:IM-20352-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003884(Factor I membrane attack complex)|interpro:IPR008993(TIMP-like, OB-fold)|rcsb pdb:1PZ8|rcsb pdb:1PZ9|rcsb pdb:1JB3|rcsb pdb:1JC7|rcsb pdb:1PXU|rcsb pdb:1PZ7|rcsb pdb:1Q56|rcsb pdb:3I70|interpro:IPR004850(Agrin NtA)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR001791(Laminin G)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR000082(SEA)|go:"GO:0043113"(receptor clustering)|go:"GO:0043236"(laminin binding)|go:"GO:0043237"(laminin-1 binding)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045121"(membrane raft)|go:"GO:0045178"(basal part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046847"(filopodium assembly)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098965"(extracellular matrix of synaptic cleft)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008201"(heparin binding)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0030424"(axon)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0033691"(sialic acid binding)|go:"GO:0035374"(chondroitin sulfate binding)|go:"GO:0002162"(dystroglycan binding)|interpro:IPR036058|interpro:IPR036364	intact:EBI-77613(chain-parent)	-	-	chain-seq-start:672|chain-seq-end:711	figure legend:Fig. 2|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/09/01	2014/10/16	rogid:b+RsTdBVRG0NoC+sRNwneIPSA1M9031	rogid:1Fb4Lc4fYdV85pxpVo7LvPBbD1o9606	intact-crc:78238479934C4562|rigid:KPWEwpRveVt+TcehrMDLvv5SvrM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P05067-PRO_0000000093	uniprotkb:P31696	intact:EBI-2431589|intact:EBI-20772365	intact:EBI-457650|uniprotkb:Q90609|uniprotkb:Q90685	psi-mi:p05067-pro_0000000093(display_long)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:agrin_chick(display_long)|uniprotkb:AGRN(gene name)|psi-mi:AGRN(display_short)|uniprotkb:AGRIN(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Cotman et al. (2000)	pubmed:10673326|imex:IM-20352	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2432147|imex:IM-20352-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-77613(chain-parent)	interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003884(Factor I membrane attack complex)|interpro:IPR008993(TIMP-like, OB-fold)|rcsb pdb:1PZ8|rcsb pdb:1PZ9|rcsb pdb:1JB3|rcsb pdb:1JC7|rcsb pdb:1PXU|rcsb pdb:1PZ7|rcsb pdb:1Q56|rcsb pdb:3I70|interpro:IPR004850(Agrin NtA)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR001791(Laminin G)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR000082(SEA)|go:"GO:0043113"(receptor clustering)|go:"GO:0043236"(laminin binding)|go:"GO:0043237"(laminin-1 binding)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045121"(membrane raft)|go:"GO:0045178"(basal part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046847"(filopodium assembly)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098965"(extracellular matrix of synaptic cleft)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008201"(heparin binding)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0030424"(axon)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0033691"(sialic acid binding)|go:"GO:0035374"(chondroitin sulfate binding)|go:"GO:0002162"(dystroglycan binding)|interpro:IPR036058|interpro:IPR036364	-	chain-seq-start:672|chain-seq-end:711	-	comment:"Nitrous acid treatment (removal of heparan sulphate GAG side chains)of Agrin almost completly abolished binding to fibrilla Abeta. Non fibrilla Abeta did not bind to Agrin."|figure legend:Fig. 1|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/09/01	2014/10/16	rogid:1Fb4Lc4fYdV85pxpVo7LvPBbD1o9606	rogid:b+RsTdBVRG0NoC+sRNwneIPSA1M9031	intact-crc:D7E498808C52512F|rigid:KPWEwpRveVt+TcehrMDLvv5SvrM	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P05067-PRO_0000000093	uniprotkb:O00468	intact:EBI-2431589|intact:EBI-20772365	intact:EBI-947482|uniprotkb:Q5SVA2|uniprotkb:Q60FE1|uniprotkb:Q7KYS8|uniprotkb:Q8N4J5|uniprotkb:Q96IC1|uniprotkb:Q9BTD4|uniprotkb:Q5SVA1	psi-mi:p05067-pro_0000000093(display_long)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:agrin_human(display_long)|uniprotkb:AGRN(gene name)|psi-mi:AGRN(display_short)|uniprotkb:AGRIN(gene name synonym)	psi-mi:"MI:0426"(light microscopy)	Cotman et al. (2000)	pubmed:10673326|imex:IM-20352	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2431652|imex:IM-20352-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-77613(chain-parent)	refseq:NP_940978.2|interpro:IPR004850(Agrin NtA)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR001791(Laminin G)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR000082(SEA)|interpro:IPR008993(TIMP-like, OB-fold)|refseq:XP_005244806.1|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003884(Factor I membrane attack complex)|mint:O00468|go:"GO:0002162"(dystroglycan binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033691"(sialic acid binding)|go:"GO:0035374"(chondroitin sulfate binding)|go:"GO:0043113"(receptor clustering)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043236"(laminin binding)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045162"(clustering of voltage-gated sodium channels)|go:"GO:0045202"(synapse)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050808"(synapse organization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|reactome:R-HSA-1971475|reactome:R-HSA-2022928|reactome:R-HSA-2024096|reactome:R-HSA-216083|reactome:R-HSA-3000171|reactome:R-HSA-3000178|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3656237|reactome:R-HSA-3656253|reactome:R-HSA-419037|reactome:R-HSA-4420332|reactome:R-HSA-975634|interpro:IPR036058|interpro:IPR036364|refseq:NP_001292204.1	-	chain-seq-start:672|chain-seq-end:711	-	comment:"Immunostaing of Agrin and Abeta (1-40) observed in senile plaques in the frontal cortex of a 92 year old AD patient."|antibodies:"Human Agrin antibody generated by rabbit immunization with a human agrin fusion protein (amino acids 780-1210) representing the N terminal half of the protein. anti Abeta (1-40) was purchased from Sigma."|figure legend:Fig 6A and B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2009/09/01	2018/09/18	rogid:1Fb4Lc4fYdV85pxpVo7LvPBbD1o9606	rogid:LRk4v4aYLk5kep9EIbjjiCGM7OM9606	intact-crc:E4E46C4A9CCC4ABE|rigid:/V1yshaJJWYJ8hRz7Q5os9eZ7fo	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P05067-PRO_0000000093	uniprotkb:O00468	intact:EBI-2431589|intact:EBI-20772365	intact:EBI-947482|uniprotkb:Q5SVA2|uniprotkb:Q60FE1|uniprotkb:Q7KYS8|uniprotkb:Q8N4J5|uniprotkb:Q96IC1|uniprotkb:Q9BTD4|uniprotkb:Q5SVA1	psi-mi:p05067-pro_0000000093(display_long)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:agrin_human(display_long)|uniprotkb:AGRN(gene name)|psi-mi:AGRN(display_short)|uniprotkb:AGRIN(gene name synonym)	psi-mi:"MI:0426"(light microscopy)	Cotman et al. (2000)	pubmed:10673326|imex:IM-20352	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2431659|imex:IM-20352-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-77613(chain-parent)	refseq:NP_940978.2|interpro:IPR004850(Agrin NtA)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR001791(Laminin G)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR000082(SEA)|interpro:IPR008993(TIMP-like, OB-fold)|refseq:XP_005244806.1|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003884(Factor I membrane attack complex)|mint:O00468|go:"GO:0002162"(dystroglycan binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033691"(sialic acid binding)|go:"GO:0035374"(chondroitin sulfate binding)|go:"GO:0043113"(receptor clustering)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043236"(laminin binding)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045162"(clustering of voltage-gated sodium channels)|go:"GO:0045202"(synapse)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050808"(synapse organization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|reactome:R-HSA-1971475|reactome:R-HSA-2022928|reactome:R-HSA-2024096|reactome:R-HSA-216083|reactome:R-HSA-3000171|reactome:R-HSA-3000178|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3656237|reactome:R-HSA-3656253|reactome:R-HSA-419037|reactome:R-HSA-4420332|reactome:R-HSA-975634|interpro:IPR036058|interpro:IPR036364|refseq:NP_001292204.1	-	chain-seq-start:672|chain-seq-end:711	-	comment:"Immunostaing of Agrin and Abeta (1-40) observed in the microvasculature in the frontal cortex of a 92 year old patient."|antibodies:"Human Agrin antibody generated by rabbit immunization with a human agrin fusion protein (amino acids 780-1210) representing the N terminal half of the protein. anti Abeta (1-40) was purchased from Sigma."|figure legend:Fig 6E and F|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2009/09/01	2018/09/18	rogid:1Fb4Lc4fYdV85pxpVo7LvPBbD1o9606	rogid:LRk4v4aYLk5kep9EIbjjiCGM7OM9606	intact-crc:8EE134B66B8B51B3|rigid:/V1yshaJJWYJ8hRz7Q5os9eZ7fo	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)