#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P46065	uniprotkb:P55203	intact:EBI-6943108|ensembl:ENSBTAP00000057125|intact:MINT-1210679	intact:EBI-6943076|uniprotkb:O02809|intact:MINT-6824834	psi-mi:guc1a_bovin(display_long)|uniprotkb:GUCA1A(gene name)|psi-mi:GUCA1A(display_short)|uniprotkb:GCAP1(gene name synonym)|uniprotkb:GUCA1(gene name synonym)|uniprotkb:Guanylate cyclase activator 1A(gene name synonym)	psi-mi:guc2d_bovin(display_long)|uniprotkb:GUCY2D(gene name)|psi-mi:GUCY2D(display_short)|uniprotkb:GUC2D(gene name synonym)|uniprotkb:Guanylate cyclase 2D, retinal(gene name synonym)|uniprotkb:Rod outer segment membrane guanylate cyclase(gene name synonym)|uniprotkb:Guanylate cyclase E(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Schrem et al. (1999)	pubmed:10037711|mint:MINT-6825358|doi:10.1074/jbc.274.10.6244	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6943104|mint:MINT-6825364	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSBTAG00000051956(gene)|ensembl:ENSBTAT00000087322(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005509"(calcium ion binding)|go:"GO:0007601"(visual perception)|go:"GO:0007602"(phototransduction)|go:"GO:0008048"(calcium sensitive guanylate cyclase activator activity)|go:"GO:0016020"(membrane)|go:"GO:0030249"(guanylate cyclase regulator activity)|go:"GO:0031282"(regulation of guanylate cyclase activity)|go:"GO:0031284"(positive regulation of guanylate cyclase activity)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0120199"(cone photoreceptor outer segment)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR028846|interpro:IPR033022|mint:P46065|rcsb pdb:2NA0|reactome:R-BTA-2514859|refseq:NP_776971.1|mint:MINT-6825368(identity)|uniprotkb:P46065(P46065)	go:"GO:0001653"(peptide receptor activity)|go:"GO:0004383"(guanylate cyclase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006182"(cGMP biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007168"(receptor guanylyl cyclase signaling pathway)|go:"GO:0007601"(visual perception)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0120200"(rod photoreceptor outer segment)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR018297|interpro:IPR000719(Protein kinase, core)|interpro:IPR011645(Haem NO binding associated)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR001054(Adenylyl cyclase class-3/4/guanylyl cyclase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR028082|interpro:IPR029787|mint:P55203|mint:MINT-6825365(identity)|uniprotkb:P55203(P55203)	-	comment:mint|function:"Stimulates guanylyl cyclase 1 (GC1) when free calcium ions concentration is low and inhibits GC1 when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of GC is a key event in recovery of the dark state of rod photoreceptors following light exposure"	function:Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction|comment:mint	figure legend:F7A|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/01/23	2014/10/16	rogid:ObJxTP2SZDw2YXDHzWxt2pp/xJ49913	rogid:S1qP5Vxu3V9QFWFYNAOBKaP34C89913	intact-crc:4C7EDB59A84671DE|rigid:5wDR4ANDI/u0XYXPJA9ThMk4afE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P81948	uniprotkb:P46065	intact:EBI-6943159|ensembl:ENSBTAP00000065307|uniprotkb:Q17QT1|intact:MINT-3387904|uniprotkb:Q5E986	intact:EBI-6943108|ensembl:ENSBTAP00000057125|intact:MINT-1210679	psi-mi:tba4a_bovin(display_long)|uniprotkb:TUBA1(gene name synonym)|uniprotkb:TUBA4A(gene name)|psi-mi:TUBA4A(display_short)|uniprotkb:Tubulin alpha-1 chain(gene name synonym)|uniprotkb:Alpha-tubulin 1(gene name synonym)	psi-mi:guc1a_bovin(display_long)|uniprotkb:GUCA1A(gene name)|psi-mi:GUCA1A(display_short)|uniprotkb:GCAP1(gene name synonym)|uniprotkb:GUCA1(gene name synonym)|uniprotkb:Guanylate cyclase activator 1A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Schrem et al. (1999)	pubmed:10037711|mint:MINT-6825358|doi:10.1074/jbc.274.10.6244	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6943154|mint:MINT-6825371	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSBTAG00000030974(gene)|ensembl:ENSBTAT00000085322(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0019901"(protein kinase binding)|interpro:IPR000217(Tubulin)|interpro:IPR002452(Alpha tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:P81948|refseq:NP_001071626.1|mint:MINT-6825375(identity)|uniprotkb:P81948(P81948)	ensembl:ENSBTAG00000051956(gene)|ensembl:ENSBTAT00000087322(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005509"(calcium ion binding)|go:"GO:0007601"(visual perception)|go:"GO:0007602"(phototransduction)|go:"GO:0008048"(calcium sensitive guanylate cyclase activator activity)|go:"GO:0016020"(membrane)|go:"GO:0030249"(guanylate cyclase regulator activity)|go:"GO:0031282"(regulation of guanylate cyclase activity)|go:"GO:0031284"(positive regulation of guanylate cyclase activity)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0120199"(cone photoreceptor outer segment)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR028846|interpro:IPR033022|mint:P46065|rcsb pdb:2NA0|reactome:R-BTA-2514859|refseq:NP_776971.1|mint:MINT-6825372(identity)|uniprotkb:P46065(P46065)	-	comment:mint|function:Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain	comment:mint|function:"Stimulates guanylyl cyclase 1 (GC1) when free calcium ions concentration is low and inhibits GC1 when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of GC is a key event in recovery of the dark state of rod photoreceptors following light exposure"	figure legend:F7B|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/01/23	2014/10/16	rogid:6Oj9O8u7E6cLUJ1eT6y5slbk7uQ9913	rogid:ObJxTP2SZDw2YXDHzWxt2pp/xJ49913	intact-crc:F20C6B52CF803F87|rigid:cvpoetdiryDyzaCQo9EwgprhTtY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P46065	uniprotkb:P55203	intact:EBI-6943108|ensembl:ENSBTAP00000057125|intact:MINT-1210679	intact:EBI-6943076|uniprotkb:O02809|intact:MINT-6824834	psi-mi:guc1a_bovin(display_long)|uniprotkb:GUCA1A(gene name)|psi-mi:GUCA1A(display_short)|uniprotkb:GCAP1(gene name synonym)|uniprotkb:GUCA1(gene name synonym)|uniprotkb:Guanylate cyclase activator 1A(gene name synonym)	psi-mi:guc2d_bovin(display_long)|uniprotkb:GUCY2D(gene name)|psi-mi:GUCY2D(display_short)|uniprotkb:GUC2D(gene name synonym)|uniprotkb:Guanylate cyclase 2D, retinal(gene name synonym)|uniprotkb:Rod outer segment membrane guanylate cyclase(gene name synonym)|uniprotkb:Guanylate cyclase E(gene name synonym)	psi-mi:"MI:0096"(pull down)	Schrem et al. (1999)	pubmed:10037711|mint:MINT-6825358|doi:10.1074/jbc.274.10.6244	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6943219|mint:MINT-6825380	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSBTAG00000051956(gene)|ensembl:ENSBTAT00000087322(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005509"(calcium ion binding)|go:"GO:0007601"(visual perception)|go:"GO:0007602"(phototransduction)|go:"GO:0008048"(calcium sensitive guanylate cyclase activator activity)|go:"GO:0016020"(membrane)|go:"GO:0030249"(guanylate cyclase regulator activity)|go:"GO:0031282"(regulation of guanylate cyclase activity)|go:"GO:0031284"(positive regulation of guanylate cyclase activity)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0120199"(cone photoreceptor outer segment)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR028846|interpro:IPR033022|mint:P46065|rcsb pdb:2NA0|reactome:R-BTA-2514859|refseq:NP_776971.1|mint:MINT-6825384(identity)|uniprotkb:P46065(P46065)	go:"GO:0001653"(peptide receptor activity)|go:"GO:0004383"(guanylate cyclase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006182"(cGMP biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007168"(receptor guanylyl cyclase signaling pathway)|go:"GO:0007601"(visual perception)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0120200"(rod photoreceptor outer segment)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR018297|interpro:IPR000719(Protein kinase, core)|interpro:IPR011645(Haem NO binding associated)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR001054(Adenylyl cyclase class-3/4/guanylyl cyclase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR028082|interpro:IPR029787|mint:P55203|mint:MINT-6825381(identity)|uniprotkb:P55203(P55203)	-	comment:mint|function:"Stimulates guanylyl cyclase 1 (GC1) when free calcium ions concentration is low and inhibits GC1 when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of GC is a key event in recovery of the dark state of rod photoreceptors following light exposure"	function:Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction|comment:mint	figure legend:F6B|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/01/23	2014/10/16	rogid:ObJxTP2SZDw2YXDHzWxt2pp/xJ49913	rogid:S1qP5Vxu3V9QFWFYNAOBKaP34C89913	intact-crc:2B8D4AB24FA792F1|rigid:5wDR4ANDI/u0XYXPJA9ThMk4afE	false	binding-associated region:73-87(MINT-6825387)	-	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0113"(western blot)
uniprotkb:P81948	uniprotkb:P46065	intact:EBI-6943159|ensembl:ENSBTAP00000065307|uniprotkb:Q17QT1|intact:MINT-3387904|uniprotkb:Q5E986	intact:EBI-6943108|ensembl:ENSBTAP00000057125|intact:MINT-1210679	psi-mi:tba4a_bovin(display_long)|uniprotkb:TUBA1(gene name synonym)|uniprotkb:TUBA4A(gene name)|psi-mi:TUBA4A(display_short)|uniprotkb:Tubulin alpha-1 chain(gene name synonym)|uniprotkb:Alpha-tubulin 1(gene name synonym)	psi-mi:guc1a_bovin(display_long)|uniprotkb:GUCA1A(gene name)|psi-mi:GUCA1A(display_short)|uniprotkb:GCAP1(gene name synonym)|uniprotkb:GUCA1(gene name synonym)|uniprotkb:Guanylate cyclase activator 1A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Schrem et al. (1999)	pubmed:10037711|mint:MINT-6825358|doi:10.1074/jbc.274.10.6244	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6943250|mint:MINT-6825389	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSBTAG00000030974(gene)|ensembl:ENSBTAT00000085322(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0019901"(protein kinase binding)|interpro:IPR000217(Tubulin)|interpro:IPR002452(Alpha tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:P81948|refseq:NP_001071626.1|mint:MINT-6825390(identity)|uniprotkb:P81948(P81948)	ensembl:ENSBTAG00000051956(gene)|ensembl:ENSBTAT00000087322(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005509"(calcium ion binding)|go:"GO:0007601"(visual perception)|go:"GO:0007602"(phototransduction)|go:"GO:0008048"(calcium sensitive guanylate cyclase activator activity)|go:"GO:0016020"(membrane)|go:"GO:0030249"(guanylate cyclase regulator activity)|go:"GO:0031282"(regulation of guanylate cyclase activity)|go:"GO:0031284"(positive regulation of guanylate cyclase activity)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0120199"(cone photoreceptor outer segment)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR028846|interpro:IPR033022|mint:P46065|rcsb pdb:2NA0|reactome:R-BTA-2514859|refseq:NP_776971.1|mint:MINT-6825393(identity)|uniprotkb:P46065(P46065)	-	comment:mint|function:Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain	comment:mint|function:"Stimulates guanylyl cyclase 1 (GC1) when free calcium ions concentration is low and inhibits GC1 when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of GC is a key event in recovery of the dark state of rod photoreceptors following light exposure"	figure legend:F6D|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/01/23	2014/10/16	rogid:6Oj9O8u7E6cLUJ1eT6y5slbk7uQ9913	rogid:ObJxTP2SZDw2YXDHzWxt2pp/xJ49913	intact-crc:489B032B3B4F4C67|rigid:cvpoetdiryDyzaCQo9EwgprhTtY	false	-	binding-associated region:73-87(MINT-6825396)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0083"(peptide synthesis)