#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P03072	uniprotkb:Q00577	intact:EBI-8658901|intact:MINT-110758	intact:EBI-1045860|ensembl:ENSP00000332706|ensembl:ENSP00000499133	psi-mi:lt_povjc(display_long)	psi-mi:pura_human(display_long)|uniprotkb:Purine-rich single-stranded DNA-binding protein alpha(gene name synonym)|uniprotkb:PURA(gene name)|psi-mi:PURA(display_short)|uniprotkb:PUR1(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Gallia et al. (1998)	mint:MINT-6549534|pubmed:9830007	taxid:10632(jcpyv)|taxid:10632(JC polyomavirus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8658894|mint:MINT-6627924	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0016787"(hydrolase activity)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039576"(suppression by virus of host JAK-STAT cascade via inhibition of JAK1 activity)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|rcsb pdb:4LIF|rcsb pdb:4LMD|rcsb pdb:4NBP|rcsb pdb:5CYN|rcsb pdb:5J40|rcsb pdb:5J47|rcsb pdb:5J4V|rcsb pdb:5J4Y|go:"GO:0003688"(DNA replication origin binding)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR003133(T antigen, Ori-binding)|interpro:IPR010932(Large T antigen, polyomavirus,  C-terminus)|refseq:NP_043512.1|interpro:IPR027417|interpro:IPR017910|interpro:IPR016392(Large T antigen, polyomaviridae)|interpro:IPR014015(Helicase, superfamily 3, DNA virus)|mint:P03072|interpro:IPR036869|mint:MINT-6627927(identity)|uniprotkb:P03072(P03072)	refseq:NP_005850.1|ensembl:ENSG00000185129(gene)|ensembl:ENST00000331327(transcript)|ensembl:ENST00000651386(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0032422"(purine-rich negative regulatory element binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0046332"(SMAD binding)|go:"GO:0046651"(lymphocyte proliferation)|go:"GO:0050673"(epithelial cell proliferation)|go:"GO:0098794"(postsynapse)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140416"(transcription regulator inhibitor activity)|interpro:IPR006628(PUR-alpha/beta/gamma, DNA/RNA-binding)|interpro:IPR030500|mint:Q00577|mint:MINT-6627925(identity)|uniprotkb:Q00577(Q00577)	-	function:Large T antigen has both transforming and trans-activating activities. Disrupts the function of host retinoblastoma protein RB1/pRb, which is a key regulator of the cell cycle. Induces the disassembly of the E2F1 transcription factors from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. Interferes with histone deacetylation mediated by HDAC1, leading to activation of transcription|function:Initiates DNA unwinding and replication via elaborate interactions with the viral origin of replication|comment:mint	-	figure legend:F1|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2008/06/26	2014/10/16	rogid:km9ATujC08WobjNwz72h5b3FDUQ10632	rogid:4NuTKCFE1X+wdaAs+0Brd8IsFS89606	intact-crc:DECB44D31E82EF35|rigid:AhWflWUCe8Bv2VumHXSNtYpfK8c	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03072	uniprotkb:Q00577	intact:EBI-8658901|intact:MINT-110758	intact:EBI-1045860|ensembl:ENSP00000332706|ensembl:ENSP00000499133	psi-mi:lt_povjc(display_long)	psi-mi:pura_human(display_long)|uniprotkb:Purine-rich single-stranded DNA-binding protein alpha(gene name synonym)|uniprotkb:PURA(gene name)|psi-mi:PURA(display_short)|uniprotkb:PUR1(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Gallia et al. (1998)	mint:MINT-6549534|pubmed:9830007	taxid:10632(jcpyv)|taxid:10632(JC polyomavirus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8658932|mint:MINT-6627929	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0016787"(hydrolase activity)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039576"(suppression by virus of host JAK-STAT cascade via inhibition of JAK1 activity)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|rcsb pdb:4LIF|rcsb pdb:4LMD|rcsb pdb:4NBP|rcsb pdb:5CYN|rcsb pdb:5J40|rcsb pdb:5J47|rcsb pdb:5J4V|rcsb pdb:5J4Y|go:"GO:0003688"(DNA replication origin binding)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR003133(T antigen, Ori-binding)|interpro:IPR010932(Large T antigen, polyomavirus,  C-terminus)|refseq:NP_043512.1|interpro:IPR027417|interpro:IPR017910|interpro:IPR016392(Large T antigen, polyomaviridae)|interpro:IPR014015(Helicase, superfamily 3, DNA virus)|mint:P03072|interpro:IPR036869|mint:MINT-6627932(identity)|uniprotkb:P03072(P03072)	refseq:NP_005850.1|ensembl:ENSG00000185129(gene)|ensembl:ENST00000331327(transcript)|ensembl:ENST00000651386(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0032422"(purine-rich negative regulatory element binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0046332"(SMAD binding)|go:"GO:0046651"(lymphocyte proliferation)|go:"GO:0050673"(epithelial cell proliferation)|go:"GO:0098794"(postsynapse)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140416"(transcription regulator inhibitor activity)|interpro:IPR006628(PUR-alpha/beta/gamma, DNA/RNA-binding)|interpro:IPR030500|mint:Q00577|mint:MINT-6627930(identity)|uniprotkb:Q00577(Q00577)	-	function:Large T antigen has both transforming and trans-activating activities. Disrupts the function of host retinoblastoma protein RB1/pRb, which is a key regulator of the cell cycle. Induces the disassembly of the E2F1 transcription factors from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. Interferes with histone deacetylation mediated by HDAC1, leading to activation of transcription|function:Initiates DNA unwinding and replication via elaborate interactions with the viral origin of replication|comment:mint	-	figure legend:F1|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2008/06/26	2014/10/16	rogid:km9ATujC08WobjNwz72h5b3FDUQ10632	rogid:4NuTKCFE1X+wdaAs+0Brd8IsFS89606	intact-crc:67643F9449B1DAB6|rigid:AhWflWUCe8Bv2VumHXSNtYpfK8c	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03070	uniprotkb:Q00577	intact:EBI-617698	intact:EBI-1045860|ensembl:ENSP00000332706|ensembl:ENSP00000499133	psi-mi:lt_sv40(display_long)	psi-mi:pura_human(display_long)|uniprotkb:Purine-rich single-stranded DNA-binding protein alpha(gene name synonym)|uniprotkb:PURA(gene name)|psi-mi:PURA(display_short)|uniprotkb:PUR1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Gallia et al. (1998)	mint:MINT-6549534|pubmed:9830007	taxid:1891767(sv40)|taxid:1891767(sv40)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8658983|mint:MINT-6627946	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0016787"(hydrolase activity)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039576"(suppression by virus of host JAK-STAT cascade via inhibition of JAK1 activity)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039649"(modulation by virus of host ubiquitin-protein ligase activity)|go:"GO:0039686"(bidirectional double-stranded viral DNA replication)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR003133(T antigen, Ori-binding)|interpro:IPR010932(Large T antigen, polyomavirus,  C-terminus)|interpro:IPR016392(Large T antigen, polyomaviridae)|interpro:IPR017910|interpro:IPR027417|interpro:IPR036869|rcsb pdb:1EJL|rcsb pdb:1GH6|rcsb pdb:1N25|rcsb pdb:1Q1S|rcsb pdb:1Q1T|rcsb pdb:1SVL|rcsb pdb:1SVM|rcsb pdb:1SVO|rcsb pdb:1TBD|rcsb pdb:1Z1D|rcsb pdb:2FUF|rcsb pdb:2H1L|rcsb pdb:2IF9|rcsb pdb:2IPR|rcsb pdb:2ITJ|rcsb pdb:2ITL|rcsb pdb:2NL8|rcsb pdb:2NTC|interpro:IPR014015(Helicase, superfamily 3, DNA virus)|rcsb pdb:2TBD|rcsb pdb:3QK2|rcsb pdb:3QN2|rcsb pdb:4E2I|rcsb pdb:4FGN|rcsb pdb:4GDF|rcsb pdb:4RXH|rcsb pdb:5D9I|refseq:YP_003708382.1|mint:P03070|dip:DIP-24251N|mint:MINT-6627949(identity)|uniprotkb:P03070(P03070)	refseq:NP_005850.1|ensembl:ENSG00000185129(gene)|ensembl:ENST00000331327(transcript)|ensembl:ENST00000651386(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0032422"(purine-rich negative regulatory element binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0046332"(SMAD binding)|go:"GO:0046651"(lymphocyte proliferation)|go:"GO:0050673"(epithelial cell proliferation)|go:"GO:0098794"(postsynapse)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140416"(transcription regulator inhibitor activity)|interpro:IPR006628(PUR-alpha/beta/gamma, DNA/RNA-binding)|interpro:IPR030500|mint:Q00577|mint:MINT-6627947(identity)|uniprotkb:Q00577(Q00577)	-	-	-	figure legend:F2|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2008/06/26	2019/10/18	rogid:IMcAp2PRxZXkbJ1eiXhJU9rD2JM1891767	rogid:4NuTKCFE1X+wdaAs+0Brd8IsFS89606	intact-crc:A46F88DCD1A35B04|rigid:L7g7sTJPNGUs+XW9ueUz24w4M1U	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03072	uniprotkb:Q00577	intact:EBI-8658901|intact:MINT-110758	intact:EBI-1045860|ensembl:ENSP00000332706|ensembl:ENSP00000499133	psi-mi:lt_povjc(display_long)	psi-mi:pura_human(display_long)|uniprotkb:Purine-rich single-stranded DNA-binding protein alpha(gene name synonym)|uniprotkb:PURA(gene name)|psi-mi:PURA(display_short)|uniprotkb:PUR1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Gallia et al. (1998)	mint:MINT-6549534|pubmed:9830007	taxid:10632(jcpyv)|taxid:10632(JC polyomavirus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8658957|mint:MINT-6627936	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0016787"(hydrolase activity)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039576"(suppression by virus of host JAK-STAT cascade via inhibition of JAK1 activity)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|rcsb pdb:4LIF|rcsb pdb:4LMD|rcsb pdb:4NBP|rcsb pdb:5CYN|rcsb pdb:5J40|rcsb pdb:5J47|rcsb pdb:5J4V|rcsb pdb:5J4Y|go:"GO:0003688"(DNA replication origin binding)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR003133(T antigen, Ori-binding)|interpro:IPR010932(Large T antigen, polyomavirus,  C-terminus)|refseq:NP_043512.1|interpro:IPR027417|interpro:IPR017910|interpro:IPR016392(Large T antigen, polyomaviridae)|interpro:IPR014015(Helicase, superfamily 3, DNA virus)|mint:P03072|interpro:IPR036869|mint:MINT-6627939(identity)|uniprotkb:P03072(P03072)	refseq:NP_005850.1|ensembl:ENSG00000185129(gene)|ensembl:ENST00000331327(transcript)|ensembl:ENST00000651386(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0032422"(purine-rich negative regulatory element binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0046332"(SMAD binding)|go:"GO:0046651"(lymphocyte proliferation)|go:"GO:0050673"(epithelial cell proliferation)|go:"GO:0098794"(postsynapse)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140416"(transcription regulator inhibitor activity)|interpro:IPR006628(PUR-alpha/beta/gamma, DNA/RNA-binding)|interpro:IPR030500|mint:Q00577|mint:MINT-6627937(identity)|uniprotkb:Q00577(Q00577)	-	function:Large T antigen has both transforming and trans-activating activities. Disrupts the function of host retinoblastoma protein RB1/pRb, which is a key regulator of the cell cycle. Induces the disassembly of the E2F1 transcription factors from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. Interferes with histone deacetylation mediated by HDAC1, leading to activation of transcription|function:Initiates DNA unwinding and replication via elaborate interactions with the viral origin of replication|comment:mint	-	figure legend:F2 F3|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2008/06/26	2014/10/16	rogid:km9ATujC08WobjNwz72h5b3FDUQ10632	rogid:4NuTKCFE1X+wdaAs+0Brd8IsFS89606	intact-crc:961CA87D27AE0D74|rigid:AhWflWUCe8Bv2VumHXSNtYpfK8c	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03072	uniprotkb:Q00577	intact:EBI-8658901|intact:MINT-110758	intact:EBI-1045860|ensembl:ENSP00000332706|ensembl:ENSP00000499133	psi-mi:lt_povjc(display_long)	psi-mi:pura_human(display_long)|uniprotkb:Purine-rich single-stranded DNA-binding protein alpha(gene name synonym)|uniprotkb:PURA(gene name)|psi-mi:PURA(display_short)|uniprotkb:PUR1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Gallia et al. (1998)	mint:MINT-6549534|pubmed:9830007	taxid:10632(jcpyv)|taxid:10632(JC polyomavirus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8658970|mint:MINT-6627941	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0016787"(hydrolase activity)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039576"(suppression by virus of host JAK-STAT cascade via inhibition of JAK1 activity)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|rcsb pdb:4LIF|rcsb pdb:4LMD|rcsb pdb:4NBP|rcsb pdb:5CYN|rcsb pdb:5J40|rcsb pdb:5J47|rcsb pdb:5J4V|rcsb pdb:5J4Y|go:"GO:0003688"(DNA replication origin binding)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR003133(T antigen, Ori-binding)|interpro:IPR010932(Large T antigen, polyomavirus,  C-terminus)|refseq:NP_043512.1|interpro:IPR027417|interpro:IPR017910|interpro:IPR016392(Large T antigen, polyomaviridae)|interpro:IPR014015(Helicase, superfamily 3, DNA virus)|mint:P03072|interpro:IPR036869|mint:MINT-6627944(identity)|uniprotkb:P03072(P03072)	refseq:NP_005850.1|ensembl:ENSG00000185129(gene)|ensembl:ENST00000331327(transcript)|ensembl:ENST00000651386(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0032422"(purine-rich negative regulatory element binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0046332"(SMAD binding)|go:"GO:0046651"(lymphocyte proliferation)|go:"GO:0050673"(epithelial cell proliferation)|go:"GO:0098794"(postsynapse)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140416"(transcription regulator inhibitor activity)|interpro:IPR006628(PUR-alpha/beta/gamma, DNA/RNA-binding)|interpro:IPR030500|mint:Q00577|mint:MINT-6627942(identity)|uniprotkb:Q00577(Q00577)	-	function:Large T antigen has both transforming and trans-activating activities. Disrupts the function of host retinoblastoma protein RB1/pRb, which is a key regulator of the cell cycle. Induces the disassembly of the E2F1 transcription factors from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. Interferes with histone deacetylation mediated by HDAC1, leading to activation of transcription|function:Initiates DNA unwinding and replication via elaborate interactions with the viral origin of replication|comment:mint	-	figure legend:F2|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2008/06/26	2014/10/16	rogid:km9ATujC08WobjNwz72h5b3FDUQ10632	rogid:4NuTKCFE1X+wdaAs+0Brd8IsFS89606	intact-crc:33EBD979F7D23C29|rigid:AhWflWUCe8Bv2VumHXSNtYpfK8c	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)