#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P15108	uniprotkb:P33313	intact:EBI-8666|ensemblfungi:YMR186W|uniprotkb:D6W010	intact:EBI-4806|uniprotkb:Q02125|uniprotkb:D6VQF0|ensemblfungi:YBR155W	psi-mi:hsc82_yeast(display_long)|uniprotkb:HSC82(gene name)|psi-mi:HSC82(display_short)|uniprotkb:YMR186W(locus name)|uniprotkb:YM8010.16(orf name)|uniprotkb:Heat shock protein Hsp90 constitutive isoform(gene name synonym)|uniprotkb:82 kDa heat shock cognate protein(gene name synonym)	psi-mi:cns1_yeast(display_long)|uniprotkb:CNS1(gene name)|psi-mi:CNS1(display_short)|uniprotkb:YBR155W(locus name)|uniprotkb:YBR1205(orf name)|uniprotkb:Cyclophilin seven suppressor 1(gene name synonym)|uniprotkb:STI1 stress-inducible protein homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Dolinski et al. (1998)	pubmed:9819421|imex:IM-19258|mint:MINT-6548333	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1781984|imex:IM-19258-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|rcsb pdb:6XLB|rcsb pdb:6XLC|rcsb pdb:6XLD|rcsb pdb:6XLE|rcsb pdb:6XLF|ensemblfungi:YMR186W(gene)|ensemblfungi:YMR186W_mRNA(transcript)|go:"GO:0000492"(box C/D snoRNP assembly)|go:"GO:0000723"(telomere maintenance)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006458"('de novo' protein folding)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042026"(protein refolding)|go:"GO:0043248"(proteasome assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|rcsb pdb:6XLG|rcsb pdb:6XLH|reactome:R-SCE-1474151|reactome:R-SCE-203615|reactome:R-SCE-3371497|reactome:R-SCE-3371511|reactome:R-SCE-3371571|reactome:R-SCE-5218920|reactome:R-SCE-6798695|reactome:R-SCE-9009391|refseq:NP_013911.1|sgd:S000004798|mint:P15108|dip:DIP-1524N	refseq:NP_009713.1|sgd:S000000359|dip:DIP-1271N|mint:P33313|ensemblfungi:YBR155W(gene)|ensemblfungi:YBR155W_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0042026"(protein refolding)|go:"GO:0043022"(ribosome binding)|go:"GO:0051879"(Hsp90 protein binding)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR044059|rcsb pdb:6HFM|rcsb pdb:6HFT	-	crc64:DBD41524091B1F9B	crc64:742F8254DFDB02A6	figure legend:Fig. 7A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/06/12	2014/10/16	rogid:A0Na3L9N4cl7acd9lSGiwKAYK1o559292	rogid:3vEtWsrh/ufn1qHwPkr6Iz+6qCs559292	intact-crc:774C53986A009C14|rigid:CUQslzrlpucR+aQW3fqOipXgisc	false	-	ha tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P33313	uniprotkb:P47103	intact:EBI-4806|uniprotkb:Q02125|uniprotkb:D6VQF0|ensemblfungi:YBR155W	intact:EBI-5436|uniprotkb:Q92323|uniprotkb:D6VWK5|ensemblfungi:YJR032W	psi-mi:cns1_yeast(display_long)|uniprotkb:CNS1(gene name)|psi-mi:CNS1(display_short)|uniprotkb:YBR155W(locus name)|uniprotkb:YBR1205(orf name)|uniprotkb:Cyclophilin seven suppressor 1(gene name synonym)|uniprotkb:STI1 stress-inducible protein homolog(gene name synonym)	psi-mi:cyp7_yeast(display_long)|uniprotkb:CPR7(gene name)|psi-mi:CPR7(display_short)|uniprotkb:YJR032W(locus name)|uniprotkb:J1585(orf name)|uniprotkb:Rotamase CYP7(gene name synonym)	psi-mi:"MI:0096"(pull down)	Dolinski et al. (1998)	pubmed:9819421|imex:IM-19258|mint:MINT-6548333	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1781996|imex:IM-19258-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009713.1|sgd:S000000359|dip:DIP-1271N|mint:P33313|ensemblfungi:YBR155W(gene)|ensemblfungi:YBR155W_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0042026"(protein refolding)|go:"GO:0043022"(ribosome binding)|go:"GO:0051879"(Hsp90 protein binding)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR044059|rcsb pdb:6HFM|rcsb pdb:6HFT	refseq:NP_012566.1|sgd:S000003793|dip:DIP-2312N|mint:P47103|ensemblfungi:YJR032W(gene)|ensemblfungi:YJR032W_mRNA(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042026"(protein refolding)|go:"GO:0051082"(unfolded protein binding)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR020892|interpro:IPR029000|rcsb pdb:5JHE|reactome:R-SCE-6781823|reactome:R-SCE-6782135|reactome:R-SCE-6782210|reactome:R-SCE-6798695	-	crc64:742F8254DFDB02A6	crc64:1532F255E8016F4F	figure legend:Fig. 8A & 8B|comment:The interaction is disrupted by cyclosporin A but not geldanamycin suggesting that the cyclophilin domain of Cpr7 participates in binding to Cns1.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/06/12	2014/10/16	rogid:3vEtWsrh/ufn1qHwPkr6Iz+6qCs559292	rogid:XYsRUaaWVHJucY5c9n661bDnKoE559292	intact-crc:05870049DC10B6C9|rigid:wkXzzwXMswk2tt3njaKrOpv/x2Q	false	ha tag:n-n	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P15108	uniprotkb:P47103	intact:EBI-8666|ensemblfungi:YMR186W|uniprotkb:D6W010	intact:EBI-5436|uniprotkb:Q92323|uniprotkb:D6VWK5|ensemblfungi:YJR032W	psi-mi:hsc82_yeast(display_long)|uniprotkb:HSC82(gene name)|psi-mi:HSC82(display_short)|uniprotkb:YMR186W(locus name)|uniprotkb:YM8010.16(orf name)|uniprotkb:Heat shock protein Hsp90 constitutive isoform(gene name synonym)|uniprotkb:82 kDa heat shock cognate protein(gene name synonym)	psi-mi:cyp7_yeast(display_long)|uniprotkb:CPR7(gene name)|psi-mi:CPR7(display_short)|uniprotkb:YJR032W(locus name)|uniprotkb:J1585(orf name)|uniprotkb:Rotamase CYP7(gene name synonym)	psi-mi:"MI:0096"(pull down)	Dolinski et al. (1998)	pubmed:9819421|imex:IM-19258|mint:MINT-6548333	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1782011|imex:IM-19258-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|rcsb pdb:6XLB|rcsb pdb:6XLC|rcsb pdb:6XLD|rcsb pdb:6XLE|rcsb pdb:6XLF|ensemblfungi:YMR186W(gene)|ensemblfungi:YMR186W_mRNA(transcript)|go:"GO:0000492"(box C/D snoRNP assembly)|go:"GO:0000723"(telomere maintenance)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006458"('de novo' protein folding)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042026"(protein refolding)|go:"GO:0043248"(proteasome assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|rcsb pdb:6XLG|rcsb pdb:6XLH|reactome:R-SCE-1474151|reactome:R-SCE-203615|reactome:R-SCE-3371497|reactome:R-SCE-3371511|reactome:R-SCE-3371571|reactome:R-SCE-5218920|reactome:R-SCE-6798695|reactome:R-SCE-9009391|refseq:NP_013911.1|sgd:S000004798|mint:P15108|dip:DIP-1524N	refseq:NP_012566.1|sgd:S000003793|dip:DIP-2312N|mint:P47103|ensemblfungi:YJR032W(gene)|ensemblfungi:YJR032W_mRNA(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042026"(protein refolding)|go:"GO:0051082"(unfolded protein binding)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR020892|interpro:IPR029000|rcsb pdb:5JHE|reactome:R-SCE-6781823|reactome:R-SCE-6782135|reactome:R-SCE-6782210|reactome:R-SCE-6798695	-	crc64:DBD41524091B1F9B	crc64:1532F255E8016F4F	figure legend:Fig. 8C|comment:Cyclosporin A as well as geldanamycin do not have any effect on the Cpr7-Hsc82 interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/06/12	2014/10/16	rogid:A0Na3L9N4cl7acd9lSGiwKAYK1o559292	rogid:XYsRUaaWVHJucY5c9n661bDnKoE559292	intact-crc:5B0F8FA57DBC418D|rigid:NU4giApwWaiZa/vkLk6SOYvopdM	false	-	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)