#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q19266 uniprotkb:Q17353 intact:EBI-319158|uniprotkb:A7VJC8|ensemblmetazoa:F09E5.1.1 intact:EBI-321762|uniprotkb:Q27GV0|uniprotkb:Q95QE9|ensemblmetazoa:F54E7.3b.1|ensemblmetazoa:F54E7.3b.2 psi-mi:kpc3_caeel(display_long)|uniprotkb:F09E5.1(orf name)|uniprotkb:pkc-3(gene name)|psi-mi:pkc-3(display_short)|uniprotkb:aPKC(gene name synonym)|uniprotkb:Atypical protein kinase C-3(gene name synonym) psi-mi:par3_caeel(display_long)|uniprotkb:par-3(gene name)|psi-mi:par-3(display_short)|uniprotkb:F54E7.3(orf name)|uniprotkb:Abnormal embryonic partitioning of cytoplasm protein 3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Tabuse et al. (1998) pubmed:9716526|imex:IM-19833 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-1812335|imex:IM-19833-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_495011.1|wormbase:F09E5.1|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012233(Protein kinase C, zeta/iota)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034877|reactome:R-CEL-5218921|go:"GO:0007369"(gastrulation)|go:"GO:0007506"(gonadal mesoderm development)|go:"GO:0008104"(protein localization)|go:"GO:0008406"(gonad development)|go:"GO:0009611"(response to wounding)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0050832"(defense response to fungus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|go:"GO:0007338"(single fertilization)|ensemblmetazoa:F09E5.1.1(transcript)|ensemblmetazoa:WBGene00004034(gene)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007163"(establishment or maintenance of cell polarity)|dip:DIP-24814N|reactome:R-CEL-1912408|reactome:R-CEL-9634635 refseq:NP_001022607.1|refseq:NP_001040857.1|refseq:NP_498217.2|wormbase:F54E7.3a|wormbase:F54E7.3b|wormbase:F54E7.3c|ensemblmetazoa:F54E7.3b.1(transcript)|ensemblmetazoa:F54E7.3b.2(transcript)|ensemblmetazoa:WBGene00003918(gene)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005912"(adherens junction)|go:"GO:0005938"(cell cortex)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007338"(single fertilization)|go:"GO:0007369"(gastrulation)|go:"GO:0008104"(protein localization)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0008406"(gonad development)|go:"GO:0009949"(polarity specification of anterior/posterior axis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030154"(cell differentiation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0040001"(establishment of mitotic spindle localization)|go:"GO:0043186"(P granule)|go:"GO:0043296"(apical junction complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0045178"(basal part of cell)|go:"GO:0045179"(apical cortex)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0007506"(gonadal mesoderm development)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0061802"(anterior cell cortex)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR021922|interpro:IPR036034|dip:DIP-25317N - - - figure legend:Fig 4A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells) - 2008/09/16 2014/10/16 rogid:ouLBmSOAJYGbW6LTfHamRpHNiAY6239 rogid:tg0WlCFGzovNQANMPpSWW1riAAY6239 intact-crc:58344588C2CC63BC|rigid:YnDtzHa4EMHNqzdNYQCkBoT5xEg false sufficient binding region:66-597|flag tag:n-n tandem tag:n-n|sufficient binding region:468-922 - - psi-mi:"MI:0086"(polyclonal antibody western blot) psi-mi:"MI:0086"(polyclonal antibody western blot) uniprotkb:Q17353 uniprotkb:Q19266 intact:EBI-321762|uniprotkb:Q27GV0|uniprotkb:Q95QE9|ensemblmetazoa:F54E7.3b.1|ensemblmetazoa:F54E7.3b.2 intact:EBI-319158|uniprotkb:A7VJC8|ensemblmetazoa:F09E5.1.1 psi-mi:par3_caeel(display_long)|uniprotkb:par-3(gene name)|psi-mi:par-3(display_short)|uniprotkb:F54E7.3(orf name)|uniprotkb:Abnormal embryonic partitioning of cytoplasm protein 3(gene name synonym) psi-mi:kpc3_caeel(display_long)|uniprotkb:F09E5.1(orf name)|uniprotkb:pkc-3(gene name)|psi-mi:pkc-3(display_short)|uniprotkb:aPKC(gene name synonym)|uniprotkb:Atypical protein kinase C-3(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Tabuse et al. (1998) pubmed:9716526|imex:IM-19833 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-1812358|imex:IM-19833-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001022607.1|refseq:NP_001040857.1|refseq:NP_498217.2|wormbase:F54E7.3a|wormbase:F54E7.3b|wormbase:F54E7.3c|ensemblmetazoa:F54E7.3b.1(transcript)|ensemblmetazoa:F54E7.3b.2(transcript)|ensemblmetazoa:WBGene00003918(gene)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005912"(adherens junction)|go:"GO:0005938"(cell cortex)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007338"(single fertilization)|go:"GO:0007369"(gastrulation)|go:"GO:0008104"(protein localization)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0008406"(gonad development)|go:"GO:0009949"(polarity specification of anterior/posterior axis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030154"(cell differentiation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0040001"(establishment of mitotic spindle localization)|go:"GO:0043186"(P granule)|go:"GO:0043296"(apical junction complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0045178"(basal part of cell)|go:"GO:0045179"(apical cortex)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0007506"(gonadal mesoderm development)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0061802"(anterior cell cortex)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR021922|interpro:IPR036034|dip:DIP-25317N refseq:NP_495011.1|wormbase:F09E5.1|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012233(Protein kinase C, zeta/iota)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034877|reactome:R-CEL-5218921|go:"GO:0007369"(gastrulation)|go:"GO:0007506"(gonadal mesoderm development)|go:"GO:0008104"(protein localization)|go:"GO:0008406"(gonad development)|go:"GO:0009611"(response to wounding)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0050832"(defense response to fungus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|go:"GO:0007338"(single fertilization)|ensemblmetazoa:F09E5.1.1(transcript)|ensemblmetazoa:WBGene00004034(gene)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007163"(establishment or maintenance of cell polarity)|dip:DIP-24814N|reactome:R-CEL-1912408|reactome:R-CEL-9634635 - - - figure legend:Fig 4B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells) - 2008/09/16 2014/10/16 rogid:tg0WlCFGzovNQANMPpSWW1riAAY6239 rogid:ouLBmSOAJYGbW6LTfHamRpHNiAY6239 intact-crc:13F5435FAEC027AB|rigid:YnDtzHa4EMHNqzdNYQCkBoT5xEg false tandem tag:n-n|sufficient binding region:468-922 sufficient binding region:66-597|flag tag:n-n - - psi-mi:"MI:0072"(monoclonal antibody western blot) psi-mi:"MI:0072"(monoclonal antibody western blot) uniprotkb:Q19266 uniprotkb:Q17353 intact:EBI-319158|uniprotkb:A7VJC8|ensemblmetazoa:F09E5.1.1 intact:EBI-321762|uniprotkb:Q27GV0|uniprotkb:Q95QE9|ensemblmetazoa:F54E7.3b.1|ensemblmetazoa:F54E7.3b.2 psi-mi:kpc3_caeel(display_long)|uniprotkb:F09E5.1(orf name)|uniprotkb:pkc-3(gene name)|psi-mi:pkc-3(display_short)|uniprotkb:aPKC(gene name synonym)|uniprotkb:Atypical protein kinase C-3(gene name synonym) psi-mi:par3_caeel(display_long)|uniprotkb:par-3(gene name)|psi-mi:par-3(display_short)|uniprotkb:F54E7.3(orf name)|uniprotkb:Abnormal embryonic partitioning of cytoplasm protein 3(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Tabuse et al. (1998) pubmed:9716526|imex:IM-19833 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0486"(UniProt) intact:EBI-1812376|imex:IM-19833-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_495011.1|wormbase:F09E5.1|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012233(Protein kinase C, zeta/iota)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034877|reactome:R-CEL-5218921|go:"GO:0007369"(gastrulation)|go:"GO:0007506"(gonadal mesoderm development)|go:"GO:0008104"(protein localization)|go:"GO:0008406"(gonad development)|go:"GO:0009611"(response to wounding)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0050832"(defense response to fungus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|go:"GO:0007338"(single fertilization)|ensemblmetazoa:F09E5.1.1(transcript)|ensemblmetazoa:WBGene00004034(gene)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007163"(establishment or maintenance of cell polarity)|dip:DIP-24814N|reactome:R-CEL-1912408|reactome:R-CEL-9634635 refseq:NP_001022607.1|refseq:NP_001040857.1|refseq:NP_498217.2|wormbase:F54E7.3a|wormbase:F54E7.3b|wormbase:F54E7.3c|ensemblmetazoa:F54E7.3b.1(transcript)|ensemblmetazoa:F54E7.3b.2(transcript)|ensemblmetazoa:WBGene00003918(gene)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005912"(adherens junction)|go:"GO:0005938"(cell cortex)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007338"(single fertilization)|go:"GO:0007369"(gastrulation)|go:"GO:0008104"(protein localization)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0008406"(gonad development)|go:"GO:0009949"(polarity specification of anterior/posterior axis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030154"(cell differentiation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0040001"(establishment of mitotic spindle localization)|go:"GO:0043186"(P granule)|go:"GO:0043296"(apical junction complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0045178"(basal part of cell)|go:"GO:0045179"(apical cortex)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0007506"(gonadal mesoderm development)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0061802"(anterior cell cortex)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR021922|interpro:IPR036034|dip:DIP-25317N - - - figure legend:Fig 6C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel-embryo)|taxid:6239(Caenorhabditis elegans embryo) - 2008/09/16 2014/10/16 rogid:ouLBmSOAJYGbW6LTfHamRpHNiAY6239 rogid:tg0WlCFGzovNQANMPpSWW1riAAY6239 intact-crc:1AF92B966A441526|rigid:YnDtzHa4EMHNqzdNYQCkBoT5xEg false - - - - psi-mi:"MI:0709"(polyclonal antibody immunostaining) psi-mi:"MI:0709"(polyclonal antibody immunostaining)