#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P0ABS8 uniprotkb:P03007 intact:EBI-549182|uniprotkb:P28689|ensemblbacteria:AAC74912|ensemblbacteria:BAA15650 intact:EBI-549131|ensemblbacteria:AAC73320|ensemblbacteria:BAA77886 psi-mi:hole_ecoli(display_long)|uniprotkb:holE(gene name)|psi-mi:holE(display_short)|uniprotkb:b1842(locus name)|uniprotkb:JW1831(locus name) psi-mi:dpo3e_ecoli(display_long)|uniprotkb:dnaQ(gene name)|psi-mi:dnaQ(display_short)|uniprotkb:mutD(gene name synonym)|uniprotkb:b0215(locus name)|uniprotkb:JW0205(locus name) psi-mi:"MI:0018"(two hybrid) Jonczyk et al. (1998) pubmed:9515927|imex:IM-20155 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2027268|imex:IM-20155-1 author score:665 - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_416356.1|refseq:WP_000916763.1|dip:DIP-39982N|ensemblbacteria:AAC74912(transcript)|ensemblbacteria:b1842(gene)|ensemblbacteria:BAA15650(gene)|ensemblbacteria:BAA15650(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0044776"(DNA polymerase III, core complex)|interpro:IPR009052(DNA polymerase III-theta, bacterial)|interpro:IPR036745|rcsb pdb:1DU2|rcsb pdb:2AE9|rcsb pdb:2AXD|rcsb pdb:2XY8|rcsb pdb:5M1S refseq:NP_414751.1|refseq:WP_001340895.1|dip:DIP-9462N|ensemblbacteria:AAC73320(transcript)|ensemblbacteria:b0215(gene)|ensemblbacteria:BAA77886(gene)|ensemblbacteria:BAA77886(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0004527"(exonuclease activity)|go:"GO:0005829"(cytosol)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0044776"(DNA polymerase III, core complex)|go:"GO:0045004"(DNA replication proofreading)|go:"GO:0046872"(metal ion binding)|interpro:IPR006054(DNA polymerase III, epsilon subunit)|interpro:IPR006309(DNA polymerase 3, epsilon subunit)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR013520(Exonuclease, RNase T and DNA polymerase III)|interpro:IPR036397|rcsb pdb:1J53|rcsb pdb:1J54|rcsb pdb:1MGZ|rcsb pdb:2GUI|rcsb pdb:2IDO|rcsb pdb:2XY8|rcsb pdb:4GX8|rcsb pdb:4GX9|rcsb pdb:5FKU|rcsb pdb:5FKV|rcsb pdb:5FKW|rcsb pdb:5M1S - crc64:3667D87327E96556 - figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2008/11/04 2014/10/16 rogid:SxpHzzC2294kTc9GlPUQNoxa9AU83333 rogid:+Xs56/RcG3EYpWsa57MFJRFspoI83333 intact-crc:76FDD7D29A02B2BF|rigid:bPLuTfTx5pvz/vmwhh1LVV4w6Io false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0ABS8 uniprotkb:P03007 intact:EBI-549182|uniprotkb:P28689|ensemblbacteria:AAC74912|ensemblbacteria:BAA15650 intact:EBI-549131|ensemblbacteria:AAC73320|ensemblbacteria:BAA77886 psi-mi:hole_ecoli(display_long)|uniprotkb:holE(gene name)|psi-mi:holE(display_short)|uniprotkb:b1842(locus name)|uniprotkb:JW1831(locus name) psi-mi:dpo3e_ecoli(display_long)|uniprotkb:dnaQ(gene name)|psi-mi:dnaQ(display_short)|uniprotkb:mutD(gene name synonym)|uniprotkb:b0215(locus name)|uniprotkb:JW0205(locus name) psi-mi:"MI:0018"(two hybrid) Jonczyk et al. (1998) pubmed:9515927|imex:IM-20155 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2027272|imex:IM-20155-2 author score:2,709 - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_416356.1|refseq:WP_000916763.1|dip:DIP-39982N|ensemblbacteria:AAC74912(transcript)|ensemblbacteria:b1842(gene)|ensemblbacteria:BAA15650(gene)|ensemblbacteria:BAA15650(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0044776"(DNA polymerase III, core complex)|interpro:IPR009052(DNA polymerase III-theta, bacterial)|interpro:IPR036745|rcsb pdb:1DU2|rcsb pdb:2AE9|rcsb pdb:2AXD|rcsb pdb:2XY8|rcsb pdb:5M1S refseq:NP_414751.1|refseq:WP_001340895.1|dip:DIP-9462N|ensemblbacteria:AAC73320(transcript)|ensemblbacteria:b0215(gene)|ensemblbacteria:BAA77886(gene)|ensemblbacteria:BAA77886(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0004527"(exonuclease activity)|go:"GO:0005829"(cytosol)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0044776"(DNA polymerase III, core complex)|go:"GO:0045004"(DNA replication proofreading)|go:"GO:0046872"(metal ion binding)|interpro:IPR006054(DNA polymerase III, epsilon subunit)|interpro:IPR006309(DNA polymerase 3, epsilon subunit)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR013520(Exonuclease, RNase T and DNA polymerase III)|interpro:IPR036397|rcsb pdb:1J53|rcsb pdb:1J54|rcsb pdb:1MGZ|rcsb pdb:2GUI|rcsb pdb:2IDO|rcsb pdb:2XY8|rcsb pdb:4GX8|rcsb pdb:4GX9|rcsb pdb:5FKU|rcsb pdb:5FKV|rcsb pdb:5FKW|rcsb pdb:5M1S - crc64:3667D87327E96556 - figure legend:Table 2,3|comment:10 fold lesser activity was observed with the mutant DnaQ|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2008/11/04 2014/10/16 rogid:SxpHzzC2294kTc9GlPUQNoxa9AU83333 rogid:+Xs56/RcG3EYpWsa57MFJRFspoI83333 intact-crc:592ABF3F4F4C53CA|rigid:bPLuTfTx5pvz/vmwhh1LVV4w6Io false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P10443 uniprotkb:P03007 intact:EBI-549111|ensemblbacteria:AAC73295|ensemblbacteria:BAA77859 intact:EBI-549131|ensemblbacteria:AAC73320|ensemblbacteria:BAA77886 psi-mi:dpo3a_ecoli(display_long)|uniprotkb:dnaE(gene name)|psi-mi:dnaE(display_short)|uniprotkb:polC(gene name synonym)|uniprotkb:b0184(locus name)|uniprotkb:JW0179(locus name) psi-mi:dpo3e_ecoli(display_long)|uniprotkb:dnaQ(gene name)|psi-mi:dnaQ(display_short)|uniprotkb:mutD(gene name synonym)|uniprotkb:b0215(locus name)|uniprotkb:JW0205(locus name) psi-mi:"MI:0018"(two hybrid) Jonczyk et al. (1998) pubmed:9515927|imex:IM-20155 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2027278|imex:IM-20155-3 author score:108 - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_414726.1|refseq:WP_001294757.1|dip:DIP-9458N|rcsb pdb:4JOM|rcsb pdb:5FKU|rcsb pdb:5FKV|rcsb pdb:5FKW|rcsb pdb:5M1S|rcsb pdb:4GX9|ensemblbacteria:AAC73295(transcript)|ensemblbacteria:b0184(gene)|ensemblbacteria:BAA77859(gene)|ensemblbacteria:BAA77859(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0044776"(DNA polymerase III, core complex)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|interpro:IPR003141(Polymerase and histidinol phosphatase, N-terminal)|interpro:IPR004013(PHP, C-terminal)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR004805(DNA polymerase III, alpha subunit)|interpro:IPR011708(Bacterial DNA polymerase III, alpha subunit)|interpro:IPR016195(Polymerase and histidinol phosphatase-like)|interpro:IPR029460|interpro:IPR040982|interpro:IPR041931|rcsb pdb:2HNH|rcsb pdb:2HQA|rcsb pdb:4GX8 refseq:NP_414751.1|refseq:WP_001340895.1|dip:DIP-9462N|ensemblbacteria:AAC73320(transcript)|ensemblbacteria:b0215(gene)|ensemblbacteria:BAA77886(gene)|ensemblbacteria:BAA77886(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0004527"(exonuclease activity)|go:"GO:0005829"(cytosol)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0044776"(DNA polymerase III, core complex)|go:"GO:0045004"(DNA replication proofreading)|go:"GO:0046872"(metal ion binding)|interpro:IPR006054(DNA polymerase III, epsilon subunit)|interpro:IPR006309(DNA polymerase 3, epsilon subunit)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR013520(Exonuclease, RNase T and DNA polymerase III)|interpro:IPR036397|rcsb pdb:1J53|rcsb pdb:1J54|rcsb pdb:1MGZ|rcsb pdb:2GUI|rcsb pdb:2IDO|rcsb pdb:2XY8|rcsb pdb:4GX8|rcsb pdb:4GX9|rcsb pdb:5FKU|rcsb pdb:5FKV|rcsb pdb:5FKW|rcsb pdb:5M1S - - - figure legend:Table 2, table 3|comment:The mutant DnaQ interacted 6 times lesser than the wild type.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2008/11/04 2014/10/16 rogid:g+4YFbE2iHTaCk4cKSf3zLmO43I83333 rogid:+Xs56/RcG3EYpWsa57MFJRFspoI83333 intact-crc:67A8633723BA1A28|rigid:pRprbu4iqLPkNkYVLMaEPnSdRbQ false - mutation decreasing interaction:96-96 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P10443 uniprotkb:P03007 intact:EBI-549111|ensemblbacteria:AAC73295|ensemblbacteria:BAA77859 intact:EBI-549131|ensemblbacteria:AAC73320|ensemblbacteria:BAA77886 psi-mi:dpo3a_ecoli(display_long)|uniprotkb:dnaE(gene name)|psi-mi:dnaE(display_short)|uniprotkb:polC(gene name synonym)|uniprotkb:b0184(locus name)|uniprotkb:JW0179(locus name) psi-mi:dpo3e_ecoli(display_long)|uniprotkb:dnaQ(gene name)|psi-mi:dnaQ(display_short)|uniprotkb:mutD(gene name synonym)|uniprotkb:b0215(locus name)|uniprotkb:JW0205(locus name) psi-mi:"MI:0018"(two hybrid) Jonczyk et al. (1998) pubmed:9515927|imex:IM-20155 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2027302|imex:IM-20155-4 author score:34 - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_414726.1|refseq:WP_001294757.1|dip:DIP-9458N|rcsb pdb:4JOM|rcsb pdb:5FKU|rcsb pdb:5FKV|rcsb pdb:5FKW|rcsb pdb:5M1S|rcsb pdb:4GX9|ensemblbacteria:AAC73295(transcript)|ensemblbacteria:b0184(gene)|ensemblbacteria:BAA77859(gene)|ensemblbacteria:BAA77859(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0044776"(DNA polymerase III, core complex)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|interpro:IPR003141(Polymerase and histidinol phosphatase, N-terminal)|interpro:IPR004013(PHP, C-terminal)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR004805(DNA polymerase III, alpha subunit)|interpro:IPR011708(Bacterial DNA polymerase III, alpha subunit)|interpro:IPR016195(Polymerase and histidinol phosphatase-like)|interpro:IPR029460|interpro:IPR040982|interpro:IPR041931|rcsb pdb:2HNH|rcsb pdb:2HQA|rcsb pdb:4GX8 refseq:NP_414751.1|refseq:WP_001340895.1|dip:DIP-9462N|ensemblbacteria:AAC73320(transcript)|ensemblbacteria:b0215(gene)|ensemblbacteria:BAA77886(gene)|ensemblbacteria:BAA77886(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0004527"(exonuclease activity)|go:"GO:0005829"(cytosol)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0044776"(DNA polymerase III, core complex)|go:"GO:0045004"(DNA replication proofreading)|go:"GO:0046872"(metal ion binding)|interpro:IPR006054(DNA polymerase III, epsilon subunit)|interpro:IPR006309(DNA polymerase 3, epsilon subunit)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR013520(Exonuclease, RNase T and DNA polymerase III)|interpro:IPR036397|rcsb pdb:1J53|rcsb pdb:1J54|rcsb pdb:1MGZ|rcsb pdb:2GUI|rcsb pdb:2IDO|rcsb pdb:2XY8|rcsb pdb:4GX8|rcsb pdb:4GX9|rcsb pdb:5FKU|rcsb pdb:5FKV|rcsb pdb:5FKW|rcsb pdb:5M1S - - - figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2008/11/04 2014/10/16 rogid:g+4YFbE2iHTaCk4cKSf3zLmO43I83333 rogid:+Xs56/RcG3EYpWsa57MFJRFspoI83333 intact-crc:A740B3870BC12A09|rigid:pRprbu4iqLPkNkYVLMaEPnSdRbQ false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P03007 uniprotkb:P10443 intact:EBI-549131|ensemblbacteria:AAC73320|ensemblbacteria:BAA77886 intact:EBI-549111|ensemblbacteria:AAC73295|ensemblbacteria:BAA77859 psi-mi:dpo3e_ecoli(display_long)|uniprotkb:dnaQ(gene name)|psi-mi:dnaQ(display_short)|uniprotkb:mutD(gene name synonym)|uniprotkb:b0215(locus name)|uniprotkb:JW0205(locus name) psi-mi:dpo3a_ecoli(display_long)|uniprotkb:dnaE(gene name)|psi-mi:dnaE(display_short)|uniprotkb:polC(gene name synonym)|uniprotkb:b0184(locus name)|uniprotkb:JW0179(locus name) psi-mi:"MI:0018"(two hybrid) Jonczyk et al. (1998) pubmed:9515927|imex:IM-20155 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2027341|imex:IM-20155-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_414751.1|refseq:WP_001340895.1|dip:DIP-9462N|ensemblbacteria:AAC73320(transcript)|ensemblbacteria:b0215(gene)|ensemblbacteria:BAA77886(gene)|ensemblbacteria:BAA77886(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0004527"(exonuclease activity)|go:"GO:0005829"(cytosol)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0044776"(DNA polymerase III, core complex)|go:"GO:0045004"(DNA replication proofreading)|go:"GO:0046872"(metal ion binding)|interpro:IPR006054(DNA polymerase III, epsilon subunit)|interpro:IPR006309(DNA polymerase 3, epsilon subunit)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR013520(Exonuclease, RNase T and DNA polymerase III)|interpro:IPR036397|rcsb pdb:1J53|rcsb pdb:1J54|rcsb pdb:1MGZ|rcsb pdb:2GUI|rcsb pdb:2IDO|rcsb pdb:2XY8|rcsb pdb:4GX8|rcsb pdb:4GX9|rcsb pdb:5FKU|rcsb pdb:5FKV|rcsb pdb:5FKW|rcsb pdb:5M1S refseq:NP_414726.1|refseq:WP_001294757.1|dip:DIP-9458N|rcsb pdb:4JOM|rcsb pdb:5FKU|rcsb pdb:5FKV|rcsb pdb:5FKW|rcsb pdb:5M1S|rcsb pdb:4GX9|ensemblbacteria:AAC73295(transcript)|ensemblbacteria:b0184(gene)|ensemblbacteria:BAA77859(gene)|ensemblbacteria:BAA77859(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0044776"(DNA polymerase III, core complex)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|interpro:IPR003141(Polymerase and histidinol phosphatase, N-terminal)|interpro:IPR004013(PHP, C-terminal)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR004805(DNA polymerase III, alpha subunit)|interpro:IPR011708(Bacterial DNA polymerase III, alpha subunit)|interpro:IPR016195(Polymerase and histidinol phosphatase-like)|interpro:IPR029460|interpro:IPR040982|interpro:IPR041931|rcsb pdb:2HNH|rcsb pdb:2HQA|rcsb pdb:4GX8 - - - figure legend:Table 3|comment:six fold weaker interaction was observed with the mutant DnaQ.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2008/11/04 2014/10/16 rogid:+Xs56/RcG3EYpWsa57MFJRFspoI83333 rogid:g+4YFbE2iHTaCk4cKSf3zLmO43I83333 intact-crc:17AEFA8521E1B3EE|rigid:pRprbu4iqLPkNkYVLMaEPnSdRbQ false mutation decreasing interaction:96-96 - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification)