#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P39875 uniprotkb:P25847 intact:EBI-6738|uniprotkb:D6W299|ensemblfungi:YOR033C intact:EBI-11352|uniprotkb:Q12423|ensemblfungi:YOL090W|uniprotkb:D6W1X8 psi-mi:exo1_yeast(display_long)|uniprotkb:EXO1(gene name)|psi-mi:EXO1(display_short)|uniprotkb:DHS1(gene name synonym)|uniprotkb:YOR033C(locus name)|uniprotkb:OR26.23(orf name)|uniprotkb:Exodeoxyribonuclease I(gene name synonym)|uniprotkb:Protein DHS1(gene name synonym) psi-mi:msh2_yeast(display_long)|uniprotkb:MSH2(gene name)|psi-mi:MSH2(display_short)|uniprotkb:YOL090W(locus name)|uniprotkb:O0935(orf name)|uniprotkb:MutS protein homolog 2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Tishkoff et al. (1997) pubmed:9207118|imex:IM-19823 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-1781867|imex:IM-19823-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_014676.1|sgd:S000005559|reactome:R-SCE-5358565|dip:DIP-2421N|ensemblfungi:YOR033C(gene)|ensemblfungi:YOR033C_mRNA(transcript)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006298"(mismatch repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0007534"(gene conversion at mating-type locus)|go:"GO:0008409"(5'-3' exonuclease activity)|go:"GO:0017108"(5'-flap endonuclease activity)|go:"GO:0031860"(telomeric 3' overhang formation)|go:"GO:0035312"(5'-3' exodeoxyribonuclease activity)|go:"GO:0044818"(mitotic G2/M transition checkpoint)|go:"GO:0046872"(metal ion binding)|interpro:IPR006084("DNA repair protein (XPGC)/yeast Rad")|interpro:IPR006085(XPG N-terminal)|interpro:IPR006086(XPG I)|interpro:IPR008918(Helix-hairpin-helix motif, class 2)|interpro:IPR019974|interpro:IPR029060|interpro:IPR032641|interpro:IPR036279|interpro:IPR037315|interpro:IPR044752|rcsb pdb:4FMO ensemblfungi:YOL090W(gene)|ensemblfungi:YOL090W_mRNA(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000406"(double-strand/single-strand DNA junction binding)|go:"GO:0000710"(meiotic mismatch repair)|go:"GO:0000735"(removal of nonhomologous ends)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006298"(mismatch repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006311"(meiotic gene conversion)|go:"GO:0006312"(mitotic recombination)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032301"(MutSalpha complex)|go:"GO:0032302"(MutSbeta complex)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043111"(replication fork arrest)|go:"GO:0043570"(maintenance of DNA repeat elements)|go:"GO:0045910"(negative regulation of DNA recombination)|interpro:IPR000432(DNA mismatch repair protein MutS, C-terminal)|interpro:IPR007695(DNA mismatch repair protein MutS-like, N-terminal)|interpro:IPR007696(DNA mismatch repair protein MutS, core)|interpro:IPR007860(DNA mismatch repair protein MutS, connector)|interpro:IPR007861(DNA mismatch repair protein MutS, clamp)|interpro:IPR011184(DNA mismatch repair protein, MSH2)|interpro:IPR016151(DNA mismatch repair protein MutS, N-terminal)|interpro:IPR027417|interpro:IPR032642|interpro:IPR036187|interpro:IPR036678|reactome:R-SCE-5358565|reactome:R-SCE-5358606|go:"GO:0032300"(mismatch repair complex)|refseq:NP_014551.1|sgd:S000005450|mint:P25847|dip:DIP-2415N - crc64:78E22F6B265DB3AA crc64:43FFD8A640138AE4 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2008/06/12 2014/10/16 rogid:sqo9MuVPozgKw5hQO4pcxFgLroM559292 rogid:PNwekSiaI58qR+dPZZQW5UNRJ+4559292 intact-crc:05055F5E7E777105|rigid:daTbCg8THbKBgwQHV1oUdK0p71k false binding-associated region:368-702 - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P39875 uniprotkb:P43246 intact:EBI-6738|uniprotkb:D6W299|ensemblfungi:YOR033C intact:EBI-355888|uniprotkb:O75488|uniprotkb:B4E2Z2|ensembl:ENSP00000233146 psi-mi:exo1_yeast(display_long)|uniprotkb:EXO1(gene name)|psi-mi:EXO1(display_short)|uniprotkb:DHS1(gene name synonym)|uniprotkb:YOR033C(locus name)|uniprotkb:OR26.23(orf name)|uniprotkb:Exodeoxyribonuclease I(gene name synonym)|uniprotkb:Protein DHS1(gene name synonym) psi-mi:msh2_human(display_long)|uniprotkb:MSH2(gene name)|psi-mi:MSH2(display_short)|uniprotkb:MutS protein homolog 2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Tishkoff et al. (1997) pubmed:9207118|imex:IM-19823 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-1781838|imex:IM-19823-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_014676.1|sgd:S000005559|reactome:R-SCE-5358565|dip:DIP-2421N|ensemblfungi:YOR033C(gene)|ensemblfungi:YOR033C_mRNA(transcript)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006298"(mismatch repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0007534"(gene conversion at mating-type locus)|go:"GO:0008409"(5'-3' exonuclease activity)|go:"GO:0017108"(5'-flap endonuclease activity)|go:"GO:0031860"(telomeric 3' overhang formation)|go:"GO:0035312"(5'-3' exodeoxyribonuclease activity)|go:"GO:0044818"(mitotic G2/M transition checkpoint)|go:"GO:0046872"(metal ion binding)|interpro:IPR006084("DNA repair protein (XPGC)/yeast Rad")|interpro:IPR006085(XPG N-terminal)|interpro:IPR006086(XPG I)|interpro:IPR008918(Helix-hairpin-helix motif, class 2)|interpro:IPR019974|interpro:IPR029060|interpro:IPR032641|interpro:IPR036279|interpro:IPR037315|interpro:IPR044752|rcsb pdb:4FMO refseq:NP_000242.1|refseq:NP_001245210.1|ensembl:ENSG00000095002(gene)|ensembl:ENST00000233146(transcript)|go:"GO:0000406"(double-strand/single-strand DNA junction binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002204"(somatic recombination of immunoglobulin genes involved in immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006281"(DNA repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0007281"(germ cell development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008584"(male gonad development)|go:"GO:0010165"(response to X-ray)|go:"GO:0010224"(response to UV-B)|go:"GO:0016020"(membrane)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0016447"(somatic recombination of immunoglobulin gene segments)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0019724"(B cell mediated immunity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032301"(MutSalpha complex)|go:"GO:0032302"(MutSbeta complex)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043570"(maintenance of DNA repeat elements)|go:"GO:0045190"(isotype switching)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051096"(positive regulation of helicase activity)|go:"GO:0071168"(protein localization to chromatin)|interpro:IPR000432(DNA mismatch repair protein MutS, C-terminal)|interpro:IPR007695(DNA mismatch repair protein MutS-like, N-terminal)|interpro:IPR007696(DNA mismatch repair protein MutS, core)|interpro:IPR007860(DNA mismatch repair protein MutS, connector)|interpro:IPR007861(DNA mismatch repair protein MutS, clamp)|interpro:IPR011184(DNA mismatch repair protein, MSH2)|interpro:IPR016151(DNA mismatch repair protein MutS, N-terminal)|interpro:IPR027417|interpro:IPR032642|interpro:IPR036187|interpro:IPR036678|mint:P43246|rcsb pdb:2O8B|rcsb pdb:2O8C|rcsb pdb:2O8D|rcsb pdb:2O8E|rcsb pdb:2O8F|rcsb pdb:3THW|rcsb pdb:3THX|rcsb pdb:3THY|rcsb pdb:3THZ|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5632927|reactome:R-HSA-5632928|reactome:R-HSA-5632968|reactome:R-HSA-6796648|dip:DIP-35054N - crc64:78E22F6B265DB3AA - figure legend:Fig. 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2008/06/12 2014/10/16 rogid:sqo9MuVPozgKw5hQO4pcxFgLroM559292 rogid:7vcyX6SkXRo28b+4b+JBg7j/ec89606 intact-crc:EF92E0E582F7E529|rigid:vmtBD3aHgxirzLv1zAR7XRzK82o false binding-associated region:368-702 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P25847 uniprotkb:P39875 intact:EBI-11352|uniprotkb:Q12423|ensemblfungi:YOL090W|uniprotkb:D6W1X8 intact:EBI-6738|uniprotkb:D6W299|ensemblfungi:YOR033C psi-mi:msh2_yeast(display_long)|uniprotkb:MSH2(gene name)|psi-mi:MSH2(display_short)|uniprotkb:YOL090W(locus name)|uniprotkb:O0935(orf name)|uniprotkb:MutS protein homolog 2(gene name synonym) psi-mi:exo1_yeast(display_long)|uniprotkb:EXO1(gene name)|psi-mi:EXO1(display_short)|uniprotkb:DHS1(gene name synonym)|uniprotkb:YOR033C(locus name)|uniprotkb:OR26.23(orf name)|uniprotkb:Exodeoxyribonuclease I(gene name synonym)|uniprotkb:Protein DHS1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Tishkoff et al. (1997) pubmed:9207118|imex:IM-19823 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-1781882|imex:IM-19823-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblfungi:YOL090W(gene)|ensemblfungi:YOL090W_mRNA(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000406"(double-strand/single-strand DNA junction binding)|go:"GO:0000710"(meiotic mismatch repair)|go:"GO:0000735"(removal of nonhomologous ends)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006298"(mismatch repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006311"(meiotic gene conversion)|go:"GO:0006312"(mitotic recombination)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032301"(MutSalpha complex)|go:"GO:0032302"(MutSbeta complex)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043111"(replication fork arrest)|go:"GO:0043570"(maintenance of DNA repeat elements)|go:"GO:0045910"(negative regulation of DNA recombination)|interpro:IPR000432(DNA mismatch repair protein MutS, C-terminal)|interpro:IPR007695(DNA mismatch repair protein MutS-like, N-terminal)|interpro:IPR007696(DNA mismatch repair protein MutS, core)|interpro:IPR007860(DNA mismatch repair protein MutS, connector)|interpro:IPR007861(DNA mismatch repair protein MutS, clamp)|interpro:IPR011184(DNA mismatch repair protein, MSH2)|interpro:IPR016151(DNA mismatch repair protein MutS, N-terminal)|interpro:IPR027417|interpro:IPR032642|interpro:IPR036187|interpro:IPR036678|reactome:R-SCE-5358565|reactome:R-SCE-5358606|go:"GO:0032300"(mismatch repair complex)|refseq:NP_014551.1|sgd:S000005450|mint:P25847|dip:DIP-2415N refseq:NP_014676.1|sgd:S000005559|reactome:R-SCE-5358565|dip:DIP-2421N|ensemblfungi:YOR033C(gene)|ensemblfungi:YOR033C_mRNA(transcript)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006298"(mismatch repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0007534"(gene conversion at mating-type locus)|go:"GO:0008409"(5'-3' exonuclease activity)|go:"GO:0017108"(5'-flap endonuclease activity)|go:"GO:0031860"(telomeric 3' overhang formation)|go:"GO:0035312"(5'-3' exodeoxyribonuclease activity)|go:"GO:0044818"(mitotic G2/M transition checkpoint)|go:"GO:0046872"(metal ion binding)|interpro:IPR006084("DNA repair protein (XPGC)/yeast Rad")|interpro:IPR006085(XPG N-terminal)|interpro:IPR006086(XPG I)|interpro:IPR008918(Helix-hairpin-helix motif, class 2)|interpro:IPR019974|interpro:IPR029060|interpro:IPR032641|interpro:IPR036279|interpro:IPR037315|interpro:IPR044752|rcsb pdb:4FMO - crc64:43FFD8A640138AE4 crc64:78E22F6B265DB3AA figure legend:Fig. 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2008/06/12 2014/10/16 rogid:PNwekSiaI58qR+dPZZQW5UNRJ+4559292 rogid:sqo9MuVPozgKw5hQO4pcxFgLroM559292 intact-crc:86CDAD38F2AC2F9A|rigid:daTbCg8THbKBgwQHV1oUdK0p71k false - sufficient binding region:382-702 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P43246 uniprotkb:P39875 intact:EBI-355888|uniprotkb:O75488|uniprotkb:B4E2Z2|ensembl:ENSP00000233146 intact:EBI-6738|uniprotkb:D6W299|ensemblfungi:YOR033C psi-mi:msh2_human(display_long)|uniprotkb:MSH2(gene name)|psi-mi:MSH2(display_short)|uniprotkb:MutS protein homolog 2(gene name synonym) psi-mi:exo1_yeast(display_long)|uniprotkb:EXO1(gene name)|psi-mi:EXO1(display_short)|uniprotkb:DHS1(gene name synonym)|uniprotkb:YOR033C(locus name)|uniprotkb:OR26.23(orf name)|uniprotkb:Exodeoxyribonuclease I(gene name synonym)|uniprotkb:Protein DHS1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Tishkoff et al. (1997) pubmed:9207118|imex:IM-19823 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-1781906|imex:IM-19823-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000242.1|refseq:NP_001245210.1|ensembl:ENSG00000095002(gene)|ensembl:ENST00000233146(transcript)|go:"GO:0000406"(double-strand/single-strand DNA junction binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002204"(somatic recombination of immunoglobulin genes involved in immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006281"(DNA repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0007281"(germ cell development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008584"(male gonad development)|go:"GO:0010165"(response to X-ray)|go:"GO:0010224"(response to UV-B)|go:"GO:0016020"(membrane)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0016447"(somatic recombination of immunoglobulin gene segments)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0019724"(B cell mediated immunity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032301"(MutSalpha complex)|go:"GO:0032302"(MutSbeta complex)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043570"(maintenance of DNA repeat elements)|go:"GO:0045190"(isotype switching)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051096"(positive regulation of helicase activity)|go:"GO:0071168"(protein localization to chromatin)|interpro:IPR000432(DNA mismatch repair protein MutS, C-terminal)|interpro:IPR007695(DNA mismatch repair protein MutS-like, N-terminal)|interpro:IPR007696(DNA mismatch repair protein MutS, core)|interpro:IPR007860(DNA mismatch repair protein MutS, connector)|interpro:IPR007861(DNA mismatch repair protein MutS, clamp)|interpro:IPR011184(DNA mismatch repair protein, MSH2)|interpro:IPR016151(DNA mismatch repair protein MutS, N-terminal)|interpro:IPR027417|interpro:IPR032642|interpro:IPR036187|interpro:IPR036678|mint:P43246|rcsb pdb:2O8B|rcsb pdb:2O8C|rcsb pdb:2O8D|rcsb pdb:2O8E|rcsb pdb:2O8F|rcsb pdb:3THW|rcsb pdb:3THX|rcsb pdb:3THY|rcsb pdb:3THZ|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5632927|reactome:R-HSA-5632928|reactome:R-HSA-5632968|reactome:R-HSA-6796648|dip:DIP-35054N refseq:NP_014676.1|sgd:S000005559|reactome:R-SCE-5358565|dip:DIP-2421N|ensemblfungi:YOR033C(gene)|ensemblfungi:YOR033C_mRNA(transcript)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006298"(mismatch repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0007534"(gene conversion at mating-type locus)|go:"GO:0008409"(5'-3' exonuclease activity)|go:"GO:0017108"(5'-flap endonuclease activity)|go:"GO:0031860"(telomeric 3' overhang formation)|go:"GO:0035312"(5'-3' exodeoxyribonuclease activity)|go:"GO:0044818"(mitotic G2/M transition checkpoint)|go:"GO:0046872"(metal ion binding)|interpro:IPR006084("DNA repair protein (XPGC)/yeast Rad")|interpro:IPR006085(XPG N-terminal)|interpro:IPR006086(XPG I)|interpro:IPR008918(Helix-hairpin-helix motif, class 2)|interpro:IPR019974|interpro:IPR029060|interpro:IPR032641|interpro:IPR036279|interpro:IPR037315|interpro:IPR044752|rcsb pdb:4FMO - - crc64:78E22F6B265DB3AA figure legend:Fig. 3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2008/06/12 2014/10/16 rogid:7vcyX6SkXRo28b+4b+JBg7j/ec89606 rogid:sqo9MuVPozgKw5hQO4pcxFgLroM559292 intact-crc:5DA05BE0FAA59A93|rigid:vmtBD3aHgxirzLv1zAR7XRzK82o false fusion protein:?-? binding-associated region:368-702|ha tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P39875 uniprotkb:P25847 intact:EBI-6738|uniprotkb:D6W299|ensemblfungi:YOR033C intact:EBI-11352|uniprotkb:Q12423|ensemblfungi:YOL090W|uniprotkb:D6W1X8 psi-mi:exo1_yeast(display_long)|uniprotkb:EXO1(gene name)|psi-mi:EXO1(display_short)|uniprotkb:DHS1(gene name synonym)|uniprotkb:YOR033C(locus name)|uniprotkb:OR26.23(orf name)|uniprotkb:Exodeoxyribonuclease I(gene name synonym)|uniprotkb:Protein DHS1(gene name synonym) psi-mi:msh2_yeast(display_long)|uniprotkb:MSH2(gene name)|psi-mi:MSH2(display_short)|uniprotkb:YOL090W(locus name)|uniprotkb:O0935(orf name)|uniprotkb:MutS protein homolog 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Tishkoff et al. (1997) pubmed:9207118|imex:IM-19823 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-1781931|imex:IM-19823-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_014676.1|sgd:S000005559|reactome:R-SCE-5358565|dip:DIP-2421N|ensemblfungi:YOR033C(gene)|ensemblfungi:YOR033C_mRNA(transcript)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006298"(mismatch repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0007534"(gene conversion at mating-type locus)|go:"GO:0008409"(5'-3' exonuclease activity)|go:"GO:0017108"(5'-flap endonuclease activity)|go:"GO:0031860"(telomeric 3' overhang formation)|go:"GO:0035312"(5'-3' exodeoxyribonuclease activity)|go:"GO:0044818"(mitotic G2/M transition checkpoint)|go:"GO:0046872"(metal ion binding)|interpro:IPR006084("DNA repair protein (XPGC)/yeast Rad")|interpro:IPR006085(XPG N-terminal)|interpro:IPR006086(XPG I)|interpro:IPR008918(Helix-hairpin-helix motif, class 2)|interpro:IPR019974|interpro:IPR029060|interpro:IPR032641|interpro:IPR036279|interpro:IPR037315|interpro:IPR044752|rcsb pdb:4FMO ensemblfungi:YOL090W(gene)|ensemblfungi:YOL090W_mRNA(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000406"(double-strand/single-strand DNA junction binding)|go:"GO:0000710"(meiotic mismatch repair)|go:"GO:0000735"(removal of nonhomologous ends)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006298"(mismatch repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006311"(meiotic gene conversion)|go:"GO:0006312"(mitotic recombination)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032301"(MutSalpha complex)|go:"GO:0032302"(MutSbeta complex)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043111"(replication fork arrest)|go:"GO:0043570"(maintenance of DNA repeat elements)|go:"GO:0045910"(negative regulation of DNA recombination)|interpro:IPR000432(DNA mismatch repair protein MutS, C-terminal)|interpro:IPR007695(DNA mismatch repair protein MutS-like, N-terminal)|interpro:IPR007696(DNA mismatch repair protein MutS, core)|interpro:IPR007860(DNA mismatch repair protein MutS, connector)|interpro:IPR007861(DNA mismatch repair protein MutS, clamp)|interpro:IPR011184(DNA mismatch repair protein, MSH2)|interpro:IPR016151(DNA mismatch repair protein MutS, N-terminal)|interpro:IPR027417|interpro:IPR032642|interpro:IPR036187|interpro:IPR036678|reactome:R-SCE-5358565|reactome:R-SCE-5358606|go:"GO:0032300"(mismatch repair complex)|refseq:NP_014551.1|sgd:S000005450|mint:P25847|dip:DIP-2415N - crc64:78E22F6B265DB3AA crc64:43FFD8A640138AE4 figure legend:Fig. 3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2008/06/12 2014/10/16 rogid:sqo9MuVPozgKw5hQO4pcxFgLroM559292 rogid:PNwekSiaI58qR+dPZZQW5UNRJ+4559292 intact-crc:8D3A468D24FBEAE9|rigid:daTbCg8THbKBgwQHV1oUdK0p71k false binding-associated region:368-702|ha tag:?-? fusion protein:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)