#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P08392	uniprotkb:P10238	intact:EBI-7185388|intact:MINT-6732561	intact:EBI-6883946|uniprotkb:B9VQI3|uniprotkb:Q09I80	psi-mi:icp4_hhv11(display_long)|uniprotkb:Transcriptional activator IE175(gene name synonym)|uniprotkb:RS1(orf name)|uniprotkb:ICP4(gene name)|psi-mi:ICP4(display_short)|uniprotkb:IE175(gene name synonym)|uniprotkb:Alpha-4 protein(gene name synonym)|uniprotkb:Infected cell protein 4(gene name synonym)	psi-mi:icp27_hhv11(display_long)|uniprotkb:Immediate-early protein IE63(gene name synonym)|uniprotkb:Infected cell protein 27(gene name synonym)|uniprotkb:VMW63(gene name synonym)|uniprotkb:UL54(orf name)	psi-mi:"MI:0096"(pull down)	Panagiotidis et al. (1997)	mint:MINT-6666744|pubmed:8995681	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8669906|mint:MINT-6733156	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P08392|go:"GO:0003677"(DNA binding)|go:"GO:0019033"(viral tegument)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0034340"(response to type I interferon)|go:"GO:0039695"(DNA-templated viral transcription)|go:"GO:0042025"(host cell nucleus)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|rcsb pdb:5MHJ|rcsb pdb:5MHK|interpro:IPR005206(Herpesvirus ICP4-like protein, N-terminal)|interpro:IPR005205(Herpesvirus ICP4-like protein, C-terminal)|mint:MINT-6733160(identity)|uniprotkb:P08392(P08392)	refseq:YP_009137130.1|go:"GO:0003723"(RNA binding)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039652"(induction by virus of host NF-kappaB cascade)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|interpro:IPR008648(Herpesvirus transcriptional regulator)|interpro:IPR031752|rcsb pdb:2KT5|rcsb pdb:4YXP|rcsb pdb:5BQK|mint:P10238|dip:DIP-57688N|mint:MINT-6733157(identity)|uniprotkb:P10238(P10238)	-	function:This IE protein is a multifunctional protein capable of migrating to the nucleus, binding to DNA, trans-activating other viral genes, and autoregulating its own synthesis. Binding of ICP4 to alpha genes causes repression of their expression. ICP4 also acts as a transcriptional activator of beta and gamma genes. ICP4 binds with high affinity to the sequence 5'-ATCGTC-3'|comment:mint	-	figure legend:F2|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2008/07/25	2014/10/16	rogid:N4JRGaMAWkQWhxa/rP/Pd/R8Iok10299	rogid:2sLoxn27Xqg4DSol0RY+RyjxNAM10299	intact-crc:5EF390A2E3398B28|rigid:oSM8pe7xRwvXtSoh11K0w8WIaU0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P08392	uniprotkb:P10238	intact:EBI-7185388|intact:MINT-6732561	intact:EBI-6883946|uniprotkb:B9VQI3|uniprotkb:Q09I80	psi-mi:icp4_hhv11(display_long)|uniprotkb:Transcriptional activator IE175(gene name synonym)|uniprotkb:RS1(orf name)|uniprotkb:ICP4(gene name)|psi-mi:ICP4(display_short)|uniprotkb:IE175(gene name synonym)|uniprotkb:Alpha-4 protein(gene name synonym)|uniprotkb:Infected cell protein 4(gene name synonym)	psi-mi:icp27_hhv11(display_long)|uniprotkb:Immediate-early protein IE63(gene name synonym)|uniprotkb:Infected cell protein 27(gene name synonym)|uniprotkb:VMW63(gene name synonym)|uniprotkb:UL54(orf name)	psi-mi:"MI:0096"(pull down)	Panagiotidis et al. (1997)	mint:MINT-6666744|pubmed:8995681	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8669880|mint:MINT-6733141	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P08392|go:"GO:0003677"(DNA binding)|go:"GO:0019033"(viral tegument)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0034340"(response to type I interferon)|go:"GO:0039695"(DNA-templated viral transcription)|go:"GO:0042025"(host cell nucleus)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|rcsb pdb:5MHJ|rcsb pdb:5MHK|interpro:IPR005206(Herpesvirus ICP4-like protein, N-terminal)|interpro:IPR005205(Herpesvirus ICP4-like protein, C-terminal)|mint:MINT-6733142(identity)|uniprotkb:P08392(P08392)	refseq:YP_009137130.1|go:"GO:0003723"(RNA binding)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039652"(induction by virus of host NF-kappaB cascade)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|interpro:IPR008648(Herpesvirus transcriptional regulator)|interpro:IPR031752|rcsb pdb:2KT5|rcsb pdb:4YXP|rcsb pdb:5BQK|mint:P10238|dip:DIP-57688N|mint:MINT-6733146(identity)|uniprotkb:P10238(P10238)	-	function:This IE protein is a multifunctional protein capable of migrating to the nucleus, binding to DNA, trans-activating other viral genes, and autoregulating its own synthesis. Binding of ICP4 to alpha genes causes repression of their expression. ICP4 also acts as a transcriptional activator of beta and gamma genes. ICP4 binds with high affinity to the sequence 5'-ATCGTC-3'|comment:mint	-	figure legend:F1 F3 F4 F5|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2008/07/25	2014/10/16	rogid:N4JRGaMAWkQWhxa/rP/Pd/R8Iok10299	rogid:2sLoxn27Xqg4DSol0RY+RyjxNAM10299	intact-crc:7FCFED98EEB1DE28|rigid:oSM8pe7xRwvXtSoh11K0w8WIaU0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P08392	uniprotkb:P08393	intact:EBI-7185388|intact:MINT-6732561	intact:EBI-6148881	psi-mi:icp4_hhv11(display_long)|uniprotkb:Transcriptional activator IE175(gene name synonym)|uniprotkb:RS1(orf name)|uniprotkb:ICP4(gene name)|psi-mi:ICP4(display_short)|uniprotkb:IE175(gene name synonym)|uniprotkb:Alpha-4 protein(gene name synonym)|uniprotkb:Infected cell protein 4(gene name synonym)	psi-mi:icp0_hhv11(display_long)|uniprotkb:ICP0(gene name)|psi-mi:ICP0(display_short)|uniprotkb:Alpha-0 protein(gene name synonym)|uniprotkb:IE110(gene name synonym)|uniprotkb:Immediate-early protein IE110(gene name synonym)|uniprotkb:Trans-acting transcriptional protein ICP0(gene name synonym)|uniprotkb:VMW110(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase ICP0(gene name synonym)	psi-mi:"MI:0096"(pull down)	Panagiotidis et al. (1997)	mint:MINT-6666744|pubmed:8995681	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8669893|mint:MINT-6733149	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P08392|go:"GO:0003677"(DNA binding)|go:"GO:0019033"(viral tegument)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0034340"(response to type I interferon)|go:"GO:0039695"(DNA-templated viral transcription)|go:"GO:0042025"(host cell nucleus)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|rcsb pdb:5MHJ|rcsb pdb:5MHK|interpro:IPR005206(Herpesvirus ICP4-like protein, N-terminal)|interpro:IPR005205(Herpesvirus ICP4-like protein, C-terminal)|mint:MINT-6733153(identity)|uniprotkb:P08392(P08392)	refseq:YP_009137074.1|refseq:YP_009137133.1|mint:P08393|dip:DIP-42446N|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0019033"(viral tegument)|go:"GO:0019046"(release from viral latency)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0034340"(response to type I interferon)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039593"(suppression by virus of host exit from mitosis)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0042025"(host cell nucleus)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0075342"(disruption by symbiont of host cell PML body)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|rcsb pdb:4WPH|rcsb pdb:4WPI|rcsb pdb:5C56|rcsb pdb:6JXU|rcsb pdb:6JXV|rcsb pdb:6JXW|rcsb pdb:6JXX|mint:MINT-6733150(identity)|uniprotkb:P08393(P08393)	-	function:This IE protein is a multifunctional protein capable of migrating to the nucleus, binding to DNA, trans-activating other viral genes, and autoregulating its own synthesis. Binding of ICP4 to alpha genes causes repression of their expression. ICP4 also acts as a transcriptional activator of beta and gamma genes. ICP4 binds with high affinity to the sequence 5'-ATCGTC-3'|comment:mint	-	figure legend:F1|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2008/07/25	2014/10/16	rogid:N4JRGaMAWkQWhxa/rP/Pd/R8Iok10299	rogid:keAdk+TW9AFPk4Yn7Rm/mC65Kv010299	intact-crc:16F979DBDC8B4FE7|rigid:dtf6P3Dix83HQbyfc8iegRfUEtc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P08392	uniprotkb:P10238	intact:EBI-7185388|intact:MINT-6732561	intact:EBI-6883946|uniprotkb:B9VQI3|uniprotkb:Q09I80	psi-mi:icp4_hhv11(display_long)|uniprotkb:Transcriptional activator IE175(gene name synonym)|uniprotkb:RS1(orf name)|uniprotkb:ICP4(gene name)|psi-mi:ICP4(display_short)|uniprotkb:IE175(gene name synonym)|uniprotkb:Alpha-4 protein(gene name synonym)|uniprotkb:Infected cell protein 4(gene name synonym)	psi-mi:icp27_hhv11(display_long)|uniprotkb:Immediate-early protein IE63(gene name synonym)|uniprotkb:Infected cell protein 27(gene name synonym)|uniprotkb:VMW63(gene name synonym)|uniprotkb:UL54(orf name)	psi-mi:"MI:0019"(coimmunoprecipitation)	Panagiotidis et al. (1997)	mint:MINT-6666744|pubmed:8995681	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8669928|mint:MINT-6733165	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P08392|go:"GO:0003677"(DNA binding)|go:"GO:0019033"(viral tegument)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0034340"(response to type I interferon)|go:"GO:0039695"(DNA-templated viral transcription)|go:"GO:0042025"(host cell nucleus)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|rcsb pdb:5MHJ|rcsb pdb:5MHK|interpro:IPR005206(Herpesvirus ICP4-like protein, N-terminal)|interpro:IPR005205(Herpesvirus ICP4-like protein, C-terminal)|mint:MINT-6733166(identity)|uniprotkb:P08392(P08392)	refseq:YP_009137130.1|go:"GO:0003723"(RNA binding)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039652"(induction by virus of host NF-kappaB cascade)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|interpro:IPR008648(Herpesvirus transcriptional regulator)|interpro:IPR031752|rcsb pdb:2KT5|rcsb pdb:4YXP|rcsb pdb:5BQK|mint:P10238|dip:DIP-57688N|mint:MINT-6733169(identity)|uniprotkb:P10238(P10238)	-	function:This IE protein is a multifunctional protein capable of migrating to the nucleus, binding to DNA, trans-activating other viral genes, and autoregulating its own synthesis. Binding of ICP4 to alpha genes causes repression of their expression. ICP4 also acts as a transcriptional activator of beta and gamma genes. ICP4 binds with high affinity to the sequence 5'-ATCGTC-3'|comment:mint	-	figure legend:F6|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2008/07/25	2014/10/16	rogid:N4JRGaMAWkQWhxa/rP/Pd/R8Iok10299	rogid:2sLoxn27Xqg4DSol0RY+RyjxNAM10299	intact-crc:1C78EF0F4E9DA6C8|rigid:oSM8pe7xRwvXtSoh11K0w8WIaU0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P08392	uniprotkb:P10238	intact:EBI-7185388|intact:MINT-6732561	intact:EBI-6883946|uniprotkb:B9VQI3|uniprotkb:Q09I80	psi-mi:icp4_hhv11(display_long)|uniprotkb:Transcriptional activator IE175(gene name synonym)|uniprotkb:RS1(orf name)|uniprotkb:ICP4(gene name)|psi-mi:ICP4(display_short)|uniprotkb:IE175(gene name synonym)|uniprotkb:Alpha-4 protein(gene name synonym)|uniprotkb:Infected cell protein 4(gene name synonym)	psi-mi:icp27_hhv11(display_long)|uniprotkb:Immediate-early protein IE63(gene name synonym)|uniprotkb:Infected cell protein 27(gene name synonym)|uniprotkb:VMW63(gene name synonym)|uniprotkb:UL54(orf name)	psi-mi:"MI:0019"(coimmunoprecipitation)	Panagiotidis et al. (1997)	mint:MINT-6666744|pubmed:8995681	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8669941|mint:MINT-6733172	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P08392|go:"GO:0003677"(DNA binding)|go:"GO:0019033"(viral tegument)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0034340"(response to type I interferon)|go:"GO:0039695"(DNA-templated viral transcription)|go:"GO:0042025"(host cell nucleus)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|rcsb pdb:5MHJ|rcsb pdb:5MHK|interpro:IPR005206(Herpesvirus ICP4-like protein, N-terminal)|interpro:IPR005205(Herpesvirus ICP4-like protein, C-terminal)|mint:MINT-6733176(identity)|uniprotkb:P08392(P08392)	refseq:YP_009137130.1|go:"GO:0003723"(RNA binding)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039652"(induction by virus of host NF-kappaB cascade)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|interpro:IPR008648(Herpesvirus transcriptional regulator)|interpro:IPR031752|rcsb pdb:2KT5|rcsb pdb:4YXP|rcsb pdb:5BQK|mint:P10238|dip:DIP-57688N|mint:MINT-6733173(identity)|uniprotkb:P10238(P10238)	-	function:This IE protein is a multifunctional protein capable of migrating to the nucleus, binding to DNA, trans-activating other viral genes, and autoregulating its own synthesis. Binding of ICP4 to alpha genes causes repression of their expression. ICP4 also acts as a transcriptional activator of beta and gamma genes. ICP4 binds with high affinity to the sequence 5'-ATCGTC-3'|comment:mint	-	figure legend:F6|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2008/07/25	2014/10/16	rogid:N4JRGaMAWkQWhxa/rP/Pd/R8Iok10299	rogid:2sLoxn27Xqg4DSol0RY+RyjxNAM10299	intact-crc:8FD7AE805A24C378|rigid:oSM8pe7xRwvXtSoh11K0w8WIaU0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P08392	uniprotkb:P10238	intact:EBI-7185388|intact:MINT-6732561	intact:EBI-6883946|uniprotkb:B9VQI3|uniprotkb:Q09I80	psi-mi:icp4_hhv11(display_long)|uniprotkb:Transcriptional activator IE175(gene name synonym)|uniprotkb:RS1(orf name)|uniprotkb:ICP4(gene name)|psi-mi:ICP4(display_short)|uniprotkb:IE175(gene name synonym)|uniprotkb:Alpha-4 protein(gene name synonym)|uniprotkb:Infected cell protein 4(gene name synonym)	psi-mi:icp27_hhv11(display_long)|uniprotkb:Immediate-early protein IE63(gene name synonym)|uniprotkb:Infected cell protein 27(gene name synonym)|uniprotkb:VMW63(gene name synonym)|uniprotkb:UL54(orf name)	psi-mi:"MI:0413"(electrophoretic mobility shift assay)	Panagiotidis et al. (1997)	mint:MINT-6666744|pubmed:8995681	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8669963|mint:MINT-6733181	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P08392|go:"GO:0003677"(DNA binding)|go:"GO:0019033"(viral tegument)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0034340"(response to type I interferon)|go:"GO:0039695"(DNA-templated viral transcription)|go:"GO:0042025"(host cell nucleus)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|rcsb pdb:5MHJ|rcsb pdb:5MHK|interpro:IPR005206(Herpesvirus ICP4-like protein, N-terminal)|interpro:IPR005205(Herpesvirus ICP4-like protein, C-terminal)|mint:MINT-6733185(identity)|uniprotkb:P08392(P08392)	refseq:YP_009137130.1|go:"GO:0003723"(RNA binding)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039652"(induction by virus of host NF-kappaB cascade)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|interpro:IPR008648(Herpesvirus transcriptional regulator)|interpro:IPR031752|rcsb pdb:2KT5|rcsb pdb:4YXP|rcsb pdb:5BQK|mint:P10238|dip:DIP-57688N|mint:MINT-6733182(identity)|uniprotkb:P10238(P10238)	-	function:This IE protein is a multifunctional protein capable of migrating to the nucleus, binding to DNA, trans-activating other viral genes, and autoregulating its own synthesis. Binding of ICP4 to alpha genes causes repression of their expression. ICP4 also acts as a transcriptional activator of beta and gamma genes. ICP4 binds with high affinity to the sequence 5'-ATCGTC-3'|comment:mint	-	figure legend:F7|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2008/07/25	2014/10/16	rogid:N4JRGaMAWkQWhxa/rP/Pd/R8Iok10299	rogid:2sLoxn27Xqg4DSol0RY+RyjxNAM10299	intact-crc:89A72902236469E8|rigid:oSM8pe7xRwvXtSoh11K0w8WIaU0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)