#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P04551	uniprotkb:Q09142	intact:EBI-1187862|ensemblfungi:"SPBC11B10.09.1:pep"	intact:EBI-2028187|ensemblfungi:"SPBC685.09.1:pep"	psi-mi:cdk1_schpo(display_long)|uniprotkb:cdc2(gene name)|psi-mi:cdc2(display_short)|uniprotkb:swo2(gene name synonym)|uniprotkb:SPBC11B10.09(orf name)|uniprotkb:pi002(orf name)|uniprotkb:p34 protein kinase(gene name synonym)|uniprotkb:cdk1(gene name synonym)|uniprotkb:Cell division control protein 2(gene name synonym)|uniprotkb:Cell division protein kinase 1(gene name synonym)	psi-mi:orc2_schpo(display_long)|uniprotkb:orc2(gene name)|psi-mi:orc2(display_short)|uniprotkb:orp2(gene name synonym)|uniprotkb:SPBC685.09(orf name)	psi-mi:"MI:0018"(two hybrid)	Leatherwood et al. (1996)	pubmed:8552194|imex:IM-20158	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2028182|imex:IM-20158-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_595629.1|reactome:R-SPO-176187|ensemblfungi:SPBC11B10.09(gene)|ensemblfungi:SPBC11B10.09.1(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0001100"(negative regulation of exit from mitosis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0030332"(cyclin binding)|go:"GO:0031031"(positive regulation of septation initiation signaling)|go:"GO:0031138"(negative regulation of conjugation with cellular fusion)|go:"GO:0031536"(positive regulation of exit from mitosis)|go:"GO:0031568"(mitotic G1 cell size control checkpoint signaling)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0035974"(meiotic spindle pole body)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0044732"(mitotic spindle pole body)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0051301"(cell division)|go:"GO:0051446"(positive regulation of meiotic cell cycle)|go:"GO:0061245"(establishment or maintenance of bipolar cell polarity)|go:"GO:0062123"(regulation of linear element maturation)|go:"GO:0072429"(response to intra-S DNA damage checkpoint signaling)|go:"GO:0072435"(response to mitotic G2 DNA damage checkpoint signaling)|go:"GO:0072441"(response to meiotic DNA replication checkpoint signaling)|go:"GO:0072686"(mitotic spindle)|go:"GO:0097472"(cyclin-dependent protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110044"(regulation of cell cycle switching, mitotic to meiotic cell cycle)|go:"GO:0110045"(negative regulation of cell cycle switching, mitotic to meiotic cell cycle)|go:"GO:0140429"(positive regulation of mitotic sister chromatid biorientation)|go:"GO:0140445"(chromosome, telomeric repeat region)|go:"GO:1902424"(negative regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902845"(negative regulation of mitotic spindle elongation)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903380"(positive regulation of mitotic chromosome condensation)|go:"GO:1903465"(positive regulation of mitotic cell cycle DNA replication)|go:"GO:1903467"(negative regulation of mitotic DNA replication initiation)|go:"GO:1903500"(negative regulation of mitotic actomyosin contractile ring assembly)|go:"GO:1904514"(positive regulation of initiation of premeiotic DNA replication)|go:"GO:1904537"(negative regulation of mitotic telomere tethering at nuclear periphery)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:1905263"(positive regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination)|go:"GO:1905757"(negative regulation of primary cell septum biogenesis)|go:"GO:1905785"(negative regulation of anaphase-promoting complex-dependent catabolic process)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:1990820"(response to mitotic DNA integrity checkpoint signaling)|go:"GO:2001033"(negative regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|dip:DIP-1076N|reactome:R-SPO-68962|reactome:R-SPO-69017|reactome:R-SPO-69202|reactome:R-SPO-68949|reactome:R-SPO-69656	interpro:IPR007220(Origin recognition complex subunit 2)|refseq:NP_596143.1|reactome:R-SPO-68616|reactome:R-SPO-68962|reactome:R-SPO-68949|reactome:R-SPO-176187|reactome:R-SPO-68689|reactome:R-SPO-68827|reactome:R-SPO-68867|ensemblfungi:SPBC685.09(gene)|ensemblfungi:SPBC685.09.1(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0043596"(nuclear replication fork)|go:"GO:1902975"(mitotic DNA replication initiation)	-	-	-	figure legend:Figure 1.|comment:A Y2H also showed interaction between orc2 and cdc18 but the data was not shown in the paper.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/11/04	2014/10/16	rogid:Xm26f9FnmjG9I6P1hrk/9kWszzY284812	rogid:x8vYz3FVPel9o0AcgDZXLos9eRU284812	intact-crc:9D47809ABE6FA80E|rigid:P1Nmshaf1YdzAX7xlUBlG2TDXq8	false	necessary binding region:1-147	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04551	uniprotkb:Q09142	intact:EBI-1187862|ensemblfungi:"SPBC11B10.09.1:pep"	intact:EBI-2028187|ensemblfungi:"SPBC685.09.1:pep"	psi-mi:cdk1_schpo(display_long)|uniprotkb:cdc2(gene name)|psi-mi:cdc2(display_short)|uniprotkb:swo2(gene name synonym)|uniprotkb:SPBC11B10.09(orf name)|uniprotkb:pi002(orf name)|uniprotkb:p34 protein kinase(gene name synonym)|uniprotkb:cdk1(gene name synonym)|uniprotkb:Cell division control protein 2(gene name synonym)|uniprotkb:Cell division protein kinase 1(gene name synonym)	psi-mi:orc2_schpo(display_long)|uniprotkb:orc2(gene name)|psi-mi:orc2(display_short)|uniprotkb:orp2(gene name synonym)|uniprotkb:SPBC685.09(orf name)	psi-mi:"MI:0096"(pull down)	Leatherwood et al. (1996)	pubmed:8552194|imex:IM-20158	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2028495|imex:IM-20158-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_595629.1|reactome:R-SPO-176187|ensemblfungi:SPBC11B10.09(gene)|ensemblfungi:SPBC11B10.09.1(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0001100"(negative regulation of exit from mitosis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0030332"(cyclin binding)|go:"GO:0031031"(positive regulation of septation initiation signaling)|go:"GO:0031138"(negative regulation of conjugation with cellular fusion)|go:"GO:0031536"(positive regulation of exit from mitosis)|go:"GO:0031568"(mitotic G1 cell size control checkpoint signaling)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0035974"(meiotic spindle pole body)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0044732"(mitotic spindle pole body)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0051301"(cell division)|go:"GO:0051446"(positive regulation of meiotic cell cycle)|go:"GO:0061245"(establishment or maintenance of bipolar cell polarity)|go:"GO:0062123"(regulation of linear element maturation)|go:"GO:0072429"(response to intra-S DNA damage checkpoint signaling)|go:"GO:0072435"(response to mitotic G2 DNA damage checkpoint signaling)|go:"GO:0072441"(response to meiotic DNA replication checkpoint signaling)|go:"GO:0072686"(mitotic spindle)|go:"GO:0097472"(cyclin-dependent protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110044"(regulation of cell cycle switching, mitotic to meiotic cell cycle)|go:"GO:0110045"(negative regulation of cell cycle switching, mitotic to meiotic cell cycle)|go:"GO:0140429"(positive regulation of mitotic sister chromatid biorientation)|go:"GO:0140445"(chromosome, telomeric repeat region)|go:"GO:1902424"(negative regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902845"(negative regulation of mitotic spindle elongation)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903380"(positive regulation of mitotic chromosome condensation)|go:"GO:1903465"(positive regulation of mitotic cell cycle DNA replication)|go:"GO:1903467"(negative regulation of mitotic DNA replication initiation)|go:"GO:1903500"(negative regulation of mitotic actomyosin contractile ring assembly)|go:"GO:1904514"(positive regulation of initiation of premeiotic DNA replication)|go:"GO:1904537"(negative regulation of mitotic telomere tethering at nuclear periphery)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:1905263"(positive regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination)|go:"GO:1905757"(negative regulation of primary cell septum biogenesis)|go:"GO:1905785"(negative regulation of anaphase-promoting complex-dependent catabolic process)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:1990820"(response to mitotic DNA integrity checkpoint signaling)|go:"GO:2001033"(negative regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|dip:DIP-1076N|reactome:R-SPO-68962|reactome:R-SPO-69017|reactome:R-SPO-69202|reactome:R-SPO-68949|reactome:R-SPO-69656	interpro:IPR007220(Origin recognition complex subunit 2)|refseq:NP_596143.1|reactome:R-SPO-68616|reactome:R-SPO-68962|reactome:R-SPO-68949|reactome:R-SPO-176187|reactome:R-SPO-68689|reactome:R-SPO-68827|reactome:R-SPO-68867|ensemblfungi:SPBC685.09(gene)|ensemblfungi:SPBC685.09.1(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0043596"(nuclear replication fork)|go:"GO:1902975"(mitotic DNA replication initiation)	-	-	-	figure legend:Figure 2.|comment:An interaction between orc2 and cdc2 was detected.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4896(schpm)|taxid:4896("Schizosaccharomyces pombe (fission yeast)")	-	2008/11/04	2014/10/16	rogid:Xm26f9FnmjG9I6P1hrk/9kWszzY284812	rogid:x8vYz3FVPel9o0AcgDZXLos9eRU284812	intact-crc:23B4D3780076658A|rigid:P1Nmshaf1YdzAX7xlUBlG2TDXq8	false	-	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P41411	uniprotkb:Q09142	intact:EBI-1207853|ensemblfungi:"SPBC14C8.07c.1:pep"	intact:EBI-2028187|ensemblfungi:"SPBC685.09.1:pep"	psi-mi:cdc18_schpo(display_long)|uniprotkb:cdc18(gene name)|psi-mi:cdc18(display_short)|uniprotkb:SPBC14C8.07c(orf name)	psi-mi:orc2_schpo(display_long)|uniprotkb:orc2(gene name)|psi-mi:orc2(display_short)|uniprotkb:orp2(gene name synonym)|uniprotkb:SPBC685.09(orf name)	psi-mi:"MI:0096"(pull down)	Leatherwood et al. (1996)	pubmed:8552194|imex:IM-20158	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2030647|imex:IM-20158-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_595910.1|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR015163(CDC6, C terminal)|interpro:IPR016314(Cell division control, Cdc6)|reactome:R-SPO-68689|reactome:R-SPO-68962|reactome:R-SPO-69017|interpro:IPR027417|reactome:R-SPO-176187|ensemblfungi:SPBC14C8.07c(gene)|ensemblfungi:SPBC14C8.07c.1(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0051301"(cell division)|go:"GO:0140530"(MCM complex loading)|go:"GO:1902985"(mitotic pre-replicative complex assembly)|go:"GO:1903468"(positive regulation of DNA replication initiation)|go:"GO:1905634"(regulation of protein localization to chromatin)|interpro:IPR036388|interpro:IPR036390|reactome:R-SPO-68949|interpro:IPR041083|reactome:R-SPO-68827|reactome:R-SPO-68867	interpro:IPR007220(Origin recognition complex subunit 2)|refseq:NP_596143.1|reactome:R-SPO-68616|reactome:R-SPO-68962|reactome:R-SPO-68949|reactome:R-SPO-176187|reactome:R-SPO-68689|reactome:R-SPO-68827|reactome:R-SPO-68867|ensemblfungi:SPBC685.09(gene)|ensemblfungi:SPBC685.09.1(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0043596"(nuclear replication fork)|go:"GO:1902975"(mitotic DNA replication initiation)	-	-	-	figure legend:Figure 4c.|comment:An interaction between orc2 and cdc18 was detected.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4896(schpm)|taxid:4896("Schizosaccharomyces pombe (fission yeast)")	-	2008/11/04	2014/10/16	rogid:jB9IGO2TuHbrQngQUhh0PiIudgg284812	rogid:x8vYz3FVPel9o0AcgDZXLos9eRU284812	intact-crc:51C4BA02FD025B04|rigid:IZ9Ct55eCXw0mbAgcEjzuRvqvNQ	false	ha tag:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)