#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q08460	uniprotkb:P17751	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-444877|uniprotkb:Q3TJH2|uniprotkb:Q3UC04|uniprotkb:Q3UKG9|uniprotkb:Q64513|uniprotkb:Q9CVF9|uniprotkb:Q9CWE7|ensembl:ENSMUSP00000130858	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:tpis_mouse(display_long)|uniprotkb:Triose-phosphate isomerase(gene name synonym)|uniprotkb:Tpi1(gene name)|psi-mi:Tpi1(display_short)|uniprotkb:Tpi(gene name synonym)|uniprotkb:Methylglyoxal synthase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_033441.2|ensembl:ENSMUSG00000023456(gene)|ensembl:ENSMUST00000172132(transcript)|go:"GO:0004807"(triose-phosphate isomerase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006096"(glycolytic process)|go:"GO:0008929"(methylglyoxal synthase activity)|go:"GO:0016853"(isomerase activity)|go:"GO:0019242"(methylglyoxal biosynthetic process)|go:"GO:0019563"(glycerol catabolic process)|go:"GO:0019682"(glyceraldehyde-3-phosphate metabolic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046166"(glyceraldehyde-3-phosphate biosynthetic process)|interpro:IPR000652(Triosephosphate isomerase)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR020861|interpro:IPR022896|interpro:IPR035990|mint:P17751|reactome:R-MMU-70171|reactome:R-MMU-70263	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:1+uasFpsjnuX50Ti23iaIawdp7k10090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P58774	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1635202|uniprotkb:P02560|uniprotkb:P46901|ensembl:ENSMUSP00000103546	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:tpm2_mouse(display_long)|uniprotkb:Tpm2(gene name)|psi-mi:Tpm2(display_short)|uniprotkb:Tpm-2(gene name synonym)|uniprotkb:Tropomyosin-2(gene name synonym)|uniprotkb:Beta-tropomyosin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_033442.2|dip:DIP-628N|ensembl:ENSMUSG00000028464(gene)|ensembl:ENSMUST00000107913(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005862"(muscle thin filament tropomyosin)|go:"GO:0005884"(actin filament)|go:"GO:0006936"(muscle contraction)|go:"GO:0007015"(actin filament organization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051015"(actin filament binding)|interpro:IPR000533(Tropomyosin)|reactome:R-MMU-390522|reactome:R-MMU-445355	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:1tQz/rVgRBdZs8ZldhnRA5OqaPc10090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q9DBP5	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1635267|uniprotkb:Q8BK17|uniprotkb:Q8VD05|uniprotkb:Q9DCS7	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:kcy_mouse(display_long)|uniprotkb:Cmpk1(gene name)|psi-mi:Cmpk1(display_short)|uniprotkb:Cmk(gene name synonym)|uniprotkb:Uck(gene name synonym)|uniprotkb:Umk(gene name synonym)|uniprotkb:Umpk(gene name synonym)|uniprotkb:Cmpk(gene name synonym)|uniprotkb:Deoxycytidylate kinase(gene name synonym)|uniprotkb:Uridine monophosphate/cytidine monophosphate kinase(gene name synonym)|uniprotkb:Nucleoside-diphosphate kinase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	interpro:IPR033690|refseq:NP_079923.3|interpro:IPR000850(Adenylate kinase)|interpro:IPR006266(UMP-CMP kinase)|interpro:IPR027417|mint:Q9DBP5|go:"GO:0004127"(cytidylate kinase activity)|go:"GO:0004550"(nucleoside diphosphate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006165"(nucleoside diphosphate phosphorylation)|go:"GO:0006207"('de novo' pyrimidine nucleobase biosynthetic process)|go:"GO:0006225"(UDP biosynthetic process)|go:"GO:0006227"(dUDP biosynthetic process)|go:"GO:0006240"(dCDP biosynthetic process)|go:"GO:0009041"(uridylate kinase activity)|go:"GO:0009142"(nucleoside triphosphate biosynthetic process)|go:"GO:0033862"(UMP kinase activity)|go:"GO:0036430"(CMP kinase activity)|go:"GO:0036431"(dCMP kinase activity)|go:"GO:0046705"(CDP biosynthetic process)|reactome:R-MMU-499943	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:I1hyl+mlW2kp29eULytDWnH/Fj410090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q9R0P9	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1635245|uniprotkb:Q9R122|ensembl:ENSMUSP00000031131	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:uchl1_mouse(display_long)|uniprotkb:Uchl1(gene name)|psi-mi:Uchl1(display_short)|uniprotkb:Ubiquitin thioesterase L1(gene name synonym)|uniprotkb:Neuron cytoplasmic protein 9.5(gene name synonym)|uniprotkb:PGP 9.5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_035800.2|ensembl:ENSMUSG00000029223(gene)|ensembl:ENSMUST00000031131(transcript)|go:"GO:0002931"(response to ischemia)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007409"(axonogenesis)|go:"GO:0007412"(axon target recognition)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008242"(omega peptidase activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0030424"(axon)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031694"(alpha-2A adrenergic receptor binding)|go:"GO:0035690"|go:"GO:0042755"(eating behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0050905"(neuromuscular process)|go:"GO:0055001"(muscle cell development)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR030297|interpro:IPR036959|interpro:IPR038765|mint:Q9R0P9|reactome:R-MMU-5689603|go:"GO:0019233"(sensory perception of pain)	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:OwNZHaBcqFPb5UKgm9WtL6AXn/o10090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P58771	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-298478|uniprotkb:P02558|uniprotkb:P19354|uniprotkb:P46902|uniprotkb:P99034|ensembl:ENSMUSP00000109315	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:tpm1_mouse(display_long)|uniprotkb:Tpm-1(gene name synonym)|uniprotkb:Tpma(gene name synonym)|uniprotkb:Tpm1(gene name)|psi-mi:Tpm1(display_short)|uniprotkb:Tropomyosin-1(gene name synonym)|uniprotkb:Alpha-tropomyosin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	ensembl:ENSMUSG00000032366(gene)|ensembl:ENSMUST00000113685(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003065"(positive regulation of heart rate by epinephrine)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0005862"(muscle thin filament tropomyosin)|go:"GO:0005884"(actin filament)|go:"GO:0006936"(muscle contraction)|go:"GO:0007015"(actin filament organization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030016"(myofibril)|go:"GO:0030049"(muscle filament sliding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031529"(ruffle organization)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043462"(regulation of ATP-dependent activity)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051693"(actin filament capping)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000533(Tropomyosin)|mint:P58771|rcsb pdb:7NEP|reactome:R-MMU-390522|reactome:R-MMU-445355|go:"GO:0003779"(actin binding)|refseq:NP_001157720.1|refseq:NP_077745.2|dip:DIP-300N	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:d/imATvus0XZvr7i//2MtbXZ7Pw10090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P20152	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-299269|ensembl:ENSMUSP00000028062|uniprotkb:O08704|uniprotkb:Q8CCH1	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:vime_mouse(display_long)|uniprotkb:Vim(gene name)|psi-mi:Vim(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	ensembl:ENSMUSG00000026728(gene)|ensembl:ENSMUST00000028062(transcript)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0005737"(cytoplasm)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014002"(astrocyte development)|go:"GO:0016363"(nuclear matrix)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070307"(lens fiber cell development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1900147"(regulation of Schwann cell migration)|go:"GO:1990254"(keratin filament binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030424"(axon)|go:"GO:0031252"(cell leading edge)|interpro:IPR027699|interpro:IPR039008|mint:P20152|reactome:R-MMU-264870|reactome:R-MMU-390522|reactome:R-MMU-9013422|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|reactome:R-MMU-9646399|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044297"(cell body)|go:"GO:0045098"(type III intermediate filament)|go:"GO:0045103"(intermediate filament-based process)|refseq:NP_035831.2|dip:DIP-188N	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid://GDvGAXOR4hUXNtVpnZefex5v410090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P54227	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1006438|ensembl:ENSMUSP00000030636|ensembl:ENSMUSP00000101494	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:stmn1_mouse(display_long)|uniprotkb:Phosphoprotein p19(gene name synonym)|uniprotkb:Leukemia-associated phosphoprotein p18(gene name synonym)|uniprotkb:Oncoprotein 18(gene name synonym)|uniprotkb:pp17(gene name synonym)|uniprotkb:Prosolin(gene name synonym)|uniprotkb:Metablastin(gene name synonym)|uniprotkb:Protein Pr22(gene name synonym)|uniprotkb:Leukemia-associated gene protein(gene name synonym)|uniprotkb:Stmn1(gene name)|psi-mi:Stmn1(display_short)|uniprotkb:Lag(gene name synonym)|uniprotkb:Lap18(gene name synonym)|uniprotkb:Pr22(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	ensembl:ENSMUSG00000028832(gene)|ensembl:ENSMUST00000030636(transcript)|ensembl:ENSMUST00000105868(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007019"(microtubule depolymerization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007409"(axonogenesis)|go:"GO:0007420"(brain development)|go:"GO:0009615"(response to virus)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0031110"(regulation of microtubule polymerization or depolymerization)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0043005"(neuron projection)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:1905098"(negative regulation of guanyl-nucleotide exchange factor activity)|interpro:IPR000956(Stathmin)|interpro:IPR030514|interpro:IPR036002|refseq:NP_062615.1	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:D/wUUo6xBHvAkifrUWlmpFX0skw10090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P50396	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634930|uniprotkb:A2AMA8|uniprotkb:Q3TBI9|uniprotkb:Q8VHM3|uniprotkb:Q91Y71|uniprotkb:Q91Z41|uniprotkb:Q96CX5|ensembl:ENSMUSP00000015435	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:gdia_mouse(display_long)|uniprotkb:Gdi1(gene name)|psi-mi:Gdi1(display_short)|uniprotkb:Rabgdia(gene name synonym)|uniprotkb:Guanosine diphosphate dissociation inhibitor 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	ensembl:ENSMUSG00000015291(gene)|ensembl:ENSMUST00000015435(transcript)|go:"GO:0005093"(Rab GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030424"(axon)|go:"GO:0030496"(midbody)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032482"(Rab protein signal transduction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|refseq:NP_034403.1|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0051592"(response to calcium ion)|go:"GO:0090315"(negative regulation of protein targeting to membrane)|interpro:IPR000806(Rab GDI protein)|interpro:IPR018203|interpro:IPR036188|mint:P50396|reactome:R-MMU-8876198|go:"GO:0043209"(myelin sheath)	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:PedrlfCE1ZCgXPtL9PZmNfOoxdo10090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P37804	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1635158|uniprotkb:Q545W0|ensembl:ENSMUSP00000034590	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:tagl_mouse(display_long)|uniprotkb:Tagln(gene name)|psi-mi:Tagln(display_short)|uniprotkb:Sm22(gene name synonym)|uniprotkb:Sm22a(gene name synonym)|uniprotkb:Smooth muscle protein 22-alpha(gene name synonym)|uniprotkb:Actin-associated protein p27(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_035656.1|ensembl:ENSMUSG00000032085(gene)|ensembl:ENSMUST00000034590(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0051015"(actin filament binding)|interpro:IPR000557(Calponin repeat)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR003096(SM22/calponin)|interpro:IPR029976|interpro:IPR036872|mint:P37804|rcsb pdb:1UJO	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:IHBUJkLp3/PTaa7vpckHTG8LWfk10090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q61599	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-644961|uniprotkb:Q3TEB3|ensembl:ENSMUSP00000032344|ensembl:ENSMUSP00000107522|ensembl:ENSMUSP00000107523	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:gdir2_mouse(display_long)|uniprotkb:Rho-GDI beta(gene name synonym)|uniprotkb:D4(gene name synonym)|uniprotkb:Arhgdib(gene name)|psi-mi:Arhgdib(display_short)|uniprotkb:Gdid4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_031512.1|refseq:NP_001288230.1|refseq:NP_001288232.1|refseq:NP_001288234.1|refseq:NP_001288237.1|refseq:NP_001288238.1|refseq:XP_006505467.1|ensembl:ENSMUSG00000030220(gene)|ensembl:ENSMUST00000032344(transcript)|ensembl:ENSMUST00000111891(transcript)|ensembl:ENSMUST00000111892(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005094"(Rho GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0071461"(cellular response to redox state)|go:"GO:1901164"(negative regulation of trophoblast cell migration)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR000406(RHO protein GDP dissociation inhibitor)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR024792|mint:Q61599|reactome:R-MMU-8980692|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013407|reactome:R-MMU-9013408|reactome:R-MMU-9013423	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:q4GoTuJcORyPFUiFyFJNmGFkMog10090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q91XH5	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1635022|ensembl:ENSMUSP00000048111|ensembl:ENSMUSP00000145412	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:q91xh5_mouse(display_long)|uniprotkb:Spr(gene name)|psi-mi:Spr(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_035597.2|ensembl:ENSMUSG00000033735(gene)|ensembl:ENSMUST00000045986(transcript)|ensembl:ENSMUST00000204757(transcript)|go:"GO:0004757"(sepiapterin reductase activity)|go:"GO:0006729"(tetrahydrobiopterin biosynthetic process)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR006393(Sepiapterin reductase)|interpro:IPR036291	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:hfojsPBDU0lNG2DKkKuqxva7oo410090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q921I1	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-761948|uniprotkb:O35421|uniprotkb:Q3UBW7|uniprotkb:Q58E69|uniprotkb:Q61803|uniprotkb:Q62357|uniprotkb:Q62358|uniprotkb:Q62359|uniprotkb:Q63915|uniprotkb:Q64515|uniprotkb:Q8VII5|uniprotkb:Q922C0|ensembl:ENSMUSP00000108264|ensembl:ENSMUSP00000035158	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:trfe_mouse(display_long)|uniprotkb:Siderophilin(gene name synonym)|uniprotkb:Beta-1 metal-binding globulin(gene name synonym)|uniprotkb:Tf(gene name)|psi-mi:Tf(display_short)|uniprotkb:Trf(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_598738.1|ensembl:ENSMUSG00000032554(gene)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0071281"(cellular response to iron ion)|go:"GO:0097433"(dense body)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:2000147"(positive regulation of cell motility)|interpro:IPR001156(Peptidase S60, transferrin lactoferrin)|interpro:IPR016357(Transferrin)|interpro:IPR018195|interpro:IPR030685|mint:Q921I1|reactome:R-MMU-114608|reactome:R-MMU-381426|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8957275|reactome:R-MMU-917937|reactome:R-MMU-917977|ensembl:ENSMUST00000035158(transcript)|ensembl:ENSMUST00000112645(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006826"(iron ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007015"(actin filament organization)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008199"(ferric iron binding)|go:"GO:0009617"(response to bacterium)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0030120"(vesicle coat)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0031982"(vesicle)|go:"GO:0034756"(regulation of iron ion transport)|go:"GO:0034986"(iron chaperone activity)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0045178"(basal part of cell)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051286"(cell tip)|go:"GO:0055037"(recycling endosome)|go:"GO:0009986"(cell surface)	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:V7U4fb+43G8NBKnZT/9PR+9HiQk10090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P10630	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634890|uniprotkb:Q61513|uniprotkb:Q61514|ensembl:ENSMUSP00000023599	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:if4a2_mouse(display_long)|uniprotkb:Eif4a2(gene name)|psi-mi:Eif4a2(display_short)|uniprotkb:Ddx2b(gene name synonym)|uniprotkb:ATP-dependent RNA helicase eIF4A-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_001116509.1|refseq:NP_001116510.1|refseq:NP_038534.2|refseq:NP_001334108.1|ensembl:ENSMUSG00000022884(gene)|ensembl:ENSMUST00000023599(transcript)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900260"(negative regulation of RNA-directed 5'-3' RNA polymerase activity)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|interpro:IPR044728|mint:P10630|reactome:R-MMU-1169408|reactome:R-MMU-156827|reactome:R-MMU-429947|reactome:R-MMU-72649|reactome:R-MMU-72662|reactome:R-MMU-72702|reactome:R-MMU-72706	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:m9i/jWfsbU+6kQvj1h06x31+awg10090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P62821	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634955|uniprotkb:P11476|uniprotkb:Q3TX44|uniprotkb:Q811M4|uniprotkb:Q96N61|uniprotkb:Q9Y3T2|ensembl:ENSMUSP00000127330	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:rab1a_mouse(display_long)|uniprotkb:Rab1A(gene name)|psi-mi:Rab1A(display_short)|uniprotkb:Rab1(gene name synonym)|uniprotkb:YPT1-related protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_033022.1|ensembl:ENSMUSG00000020149(gene)|ensembl:ENSMUST00000163483(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007030"(Golgi organization)|go:"GO:0012505"(endomembrane system)|go:"GO:0016477"(cell migration)|go:"GO:0019068"(virion assembly)|go:"GO:0030252"(growth hormone secretion)|go:"GO:0032402"(melanosome transport)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0042470"(melanosome)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043025"(neuronal cell body)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0090110"(COPII-coated vesicle cargo loading)|go:"GO:0098793"(presynapse)|go:"GO:1903020"(positive regulation of glycoprotein metabolic process)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P62821|reactome:R-MMU-162658|reactome:R-MMU-204005|reactome:R-MMU-6807878|reactome:R-MMU-6811434|reactome:R-MMU-8873719|reactome:R-MMU-8876198	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:Pa9NYKiCNXtxRwthh1r/pGbZyf010090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P09671	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1635071|uniprotkb:Q8VEM5|uniprotkb:Q64670|ensembl:ENSMUSP00000007012	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:sodm_mouse(display_long)|uniprotkb:Sod2(gene name)|psi-mi:Sod2(display_short)|uniprotkb:Sod-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_038699.2|ensembl:ENSMUSG00000006818(gene)|ensembl:ENSMUST00000007012(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0000303"(response to superoxide)|go:"GO:0001306"(age-dependent response to oxidative stress)|go:"GO:0001315"(age-dependent response to reactive oxygen species)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0001889"(liver development)|go:"GO:0003032"(detection of oxygen)|go:"GO:0003069"(acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0003677"(DNA binding)|go:"GO:0004784"(superoxide dismutase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007507"(heart development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009409"(response to cold)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010042"(response to manganese ion)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010269"(response to selenium ion)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010729"(positive regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014823"(response to activity)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0019825"(oxygen binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032364"(oxygen homeostasis)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033591"(response to L-ascorbic acid)|go:"GO:0034021"(response to silicon dioxide)|go:"GO:0035900"(response to isolation stress)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043209"(myelin sheath)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048666"(neuron development)|go:"GO:0048678"(response to axon injury)|go:"GO:0048773"(erythrophore differentiation)|go:"GO:0050665"(hydrogen peroxide biosynthetic process)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0071000"(response to magnetism)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902631"(negative regulation of membrane hyperpolarization)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|go:"GO:1905932"(positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching)|interpro:IPR001189(Manganese and iron superoxide dismutase)|interpro:IPR019831|interpro:IPR019832|interpro:IPR019833|interpro:IPR036314|interpro:IPR036324|mint:P09671|reactome:R-MMU-2151201|reactome:R-MMU-3299685	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:ElUPIiA1JSb5vbfqnibv3He227E10090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P07214	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1635010|ensembl:ENSMUSP00000018737|ensembl:ENSMUSP00000151000	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:sprc_mouse(display_long)|uniprotkb:Sparc(gene name)|psi-mi:Sparc(display_short)|uniprotkb:Secreted protein acidic and rich in cysteine(gene name synonym)|uniprotkb:Osteonectin(gene name synonym)|uniprotkb:Basement-membrane protein 40(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_033268.1|ensembl:ENSMUSG00000018593(gene)|ensembl:ENSMUST00000018737(transcript)|ensembl:ENSMUST00000214685(transcript)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030324"(lung development)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0031982"(vesicle)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043473"(pigmentation)|go:"GO:0045202"(synapse)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0060348"(bone development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR001999(Osteonectin-like, conserved site)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR011992(EF-Hand type)|interpro:IPR015369(Follistatin)|interpro:IPR018247|interpro:IPR019577|interpro:IPR036058|interpro:IPR037641|mint:P07214|reactome:R-MMU-114608|reactome:R-MMU-3000178|reactome:R-MMU-3000497	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:1bxIUD08asD8bUNWlQgC3ha5Jr010090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P14206	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1183792|ensembl:ENSMUSP00000035105|ensembl:ENSMUSP00000148933|uniprotkb:Q58E74|uniprotkb:Q8BHL0|uniprotkb:Q8BNL2|uniprotkb:Q91V31|uniprotkb:Q9CY13	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:rssa_mouse(display_long)|uniprotkb:Rpsa(gene name)|psi-mi:Rpsa(display_short)|uniprotkb:Lamr1(gene name synonym)|uniprotkb:Laminin receptor 1(gene name synonym)|uniprotkb:37/67 kDa laminin receptor(gene name synonym)|uniprotkb:Laminin-binding protein precursor p40(gene name synonym)|uniprotkb:37 kDa oncofetal antigen(gene name synonym)|uniprotkb:OFA/iLRP(gene name synonym)|uniprotkb:P40-8(gene name synonym)|uniprotkb:37 kDa laminin receptor precursor(gene name synonym)|uniprotkb:67 kDa laminin receptor(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	ensembl:ENSMUSG00000032518(gene)|refseq:NP_035159.3|ensembl:ENSMUST00000035105(transcript)|ensembl:ENSMUST00000217317(transcript)|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005055"(laminin receptor activity)|go:"GO:0005604"(basement membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006412"(translation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0043022"(ribosome binding)|interpro:IPR005707(Ribosomal protein S2, eukaryotic/archaeal)|interpro:IPR018130|interpro:IPR023591|interpro:IPR027498|interpro:IPR027504|interpro:IPR032281|mint:P14206|reactome:R-MMU-156827|go:"GO:0043025"(neuronal cell body)|reactome:R-MMU-1799339|reactome:R-MMU-6791226|reactome:R-MMU-72649|reactome:R-MMU-72689|reactome:R-MMU-72695|reactome:R-MMU-72702|reactome:R-MMU-72706|reactome:R-MMU-975956|reactome:R-MMU-975957|go:"GO:0043236"(laminin binding)|go:"GO:0045202"(synapse)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR001865(Ribosomal protein S2)|dip:DIP-38089N	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:Qf5VO9t+mZnGd/vuxHsQyYBuYSQ10090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P08228	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1635090|ensembl:ENSMUSP00000023707	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:sodc_mouse(display_long)|uniprotkb:Sod1(gene name)|psi-mi:Sod1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_035564.1|dip:DIP-48691N|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043209"(myelin sheath)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045541"(negative regulation of cholesterol biosynthetic process)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046688"(response to copper ion)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048678"(response to axon injury)|go:"GO:0050665"(hydrogen peroxide biosynthetic process)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060047"(heart contraction)|go:"GO:0060052"(neurofilament cytoskeleton organization)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071318"(cellular response to ATP)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0097332"(response to antipsychotic drug)|go:"GO:1902177"(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR001424(Superoxide dismutase, copper/zinc binding)|interpro:IPR018152|interpro:IPR024134|interpro:IPR036423|mint:P08228|rcsb pdb:3GTT|rcsb pdb:3GTV|rcsb pdb:3LTV|reactome:R-MMU-114608|reactome:R-MMU-3299685|ensembl:ENSMUSG00000022982(gene)|ensembl:ENSMUST00000023707(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0000303"(response to superoxide)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001975"(response to amphetamine)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0004784"(superoxide dismutase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005764"(lysosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007566"(embryo implantation)|go:"GO:0007568"(aging)|go:"GO:0007569"(cell aging)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009408"(response to heat)|go:"GO:0010033"(response to organic substance)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0019899"(enzyme binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0031045"(dense core granule)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032287"(peripheral nervous system myelin maintenance)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0042802"(identical protein binding)	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:BeyfJ/d3Dn+3pu1Nkl8n/x4Qriw10090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q8BH97	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634986|uniprotkb:Q58E50|uniprotkb:Q8R137|uniprotkb:Q99K35|uniprotkb:Q9CTD4|ensembl:ENSMUSP00000019683|ensembl:ENSMUSP00000148227	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:rcn3_mouse(display_long)|uniprotkb:Rcn3(gene name)|psi-mi:Rcn3(display_short)|uniprotkb:D7Ertd671e(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_080831.2|refseq:XP_006541049.1|refseq:XP_006541050.1|ensembl:ENSMUSG00000019539(gene)|ensembl:ENSMUST00000019683(transcript)|ensembl:ENSMUST00000211352(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0009306"(protein secretion)|go:"GO:0010952"(positive regulation of peptidase activity)|go:"GO:0015031"(protein transport)|go:"GO:0032964"(collagen biosynthetic process)|go:"GO:0036503"(ERAD pathway)|go:"GO:0043129"(surfactant homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0060428"(lung epithelium development)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:Q8BH97	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:26LeeOGAYPBtelZJgFFIiIKTGwg10090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q60854	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1635033|ensembl:ENSMUSP00000041016|ensembl:ENSMUSP00000075848|ensembl:ENSMUSP00000131115	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:spb6_mouse(display_long)|uniprotkb:Serpinb6(gene name)|psi-mi:Serpinb6(display_short)|uniprotkb:Serpinb6a(gene name synonym)|uniprotkb:Spi3(gene name synonym)|uniprotkb:Placental thrombin inhibitor(gene name synonym)|uniprotkb:Proteinase inhibitor 6(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:XP_011242601.1|refseq:XP_011242602.1|refseq:XP_011242603.1|refseq:NP_001157590.1|refseq:NP_001230121.1|refseq:NP_033280.1|refseq:XP_006516686.1|ensembl:ENSMUSG00000060147(gene)|ensembl:ENSMUST00000043552(transcript)|ensembl:ENSMUST00000076532(transcript)|ensembl:ENSMUST00000167163(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008406"(gonad development)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0097180"(serine protease inhibitor complex)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR023795|interpro:IPR023796|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|mint:Q60854|rcsb pdb:1M37|reactome:R-MMU-6798695|reactome:R-MMU-75205	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:wSzHfc4BZJ7ziNu3t0ouBi5mhVE10090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P22599	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634866|uniprotkb:Q61283|uniprotkb:Q80ZH5|uniprotkb:Q8VC20|ensembl:ENSMUSP00000093101|ensembl:ENSMUSP00000127266|ensembl:ENSMUSP00000139941	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:a1at2_mouse(display_long)|uniprotkb:Serpina1b(gene name)|psi-mi:Serpina1b(display_short)|uniprotkb:Aat2(gene name synonym)|uniprotkb:Dom2(gene name synonym)|uniprotkb:Spi1-2(gene name synonym)|uniprotkb:Serine protease inhibitor 1-2(gene name synonym)|uniprotkb:Serine protease inhibitor A1b(gene name synonym)|uniprotkb:Alpha-1 protease inhibitor 2(gene name synonym)|uniprotkb:Alpha-1-antiproteinase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_033270.3|ensembl:ENSMUSG00000071178(gene)|ensembl:ENSMUST00000095450(transcript)|ensembl:ENSMUST00000164454(transcript)|ensembl:ENSMUST00000186166(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002020"(protease binding)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0006953"(acute-phase response)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0034097"(response to cytokine)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043434"(response to peptide hormone)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR023795|interpro:IPR023796|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|mint:P22599	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:bh2KJP6dEesnMNCZHLfa39NHEKo10090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P29758	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634702|ensembl:ENSMUSP00000081544	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:oat_mouse(display_long)|uniprotkb:Oat(gene name)|psi-mi:Oat(display_short)|uniprotkb:Ornithine--oxo-acid aminotransferase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_058674.1|ensembl:ENSMUSG00000030934(gene)|ensembl:ENSMUST00000084500(transcript)|go:"GO:0004587"(ornithine-oxo-acid transaminase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0010121"(arginine catabolic process to proline via ornithine)|go:"GO:0019544"(arginine catabolic process to glutamate)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0050155"("ornithine(lysine) transaminase activity")|go:"GO:0055129"(L-proline biosynthetic process)|interpro:IPR005814(Aminotransferase class-III)|interpro:IPR010164(Ornithine aminotransferase)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|mint:P29758|reactome:R-MMU-8964539	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:TdjSPZO4bNIa0ZfwGpfXTIA4MnU10090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P09411	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634776|uniprotkb:Q3TPE6|uniprotkb:Q3UKV8|uniprotkb:Q5XJE7|ensembl:ENSMUSP00000080302	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:pgk1_mouse(display_long)|uniprotkb:Pgk1(gene name)|psi-mi:Pgk1(display_short)|uniprotkb:Pgk-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_032854.2|dip:DIP-51710N|ensembl:ENSMUSG00000062070(gene)|ensembl:ENSMUST00000081593(transcript)|go:"GO:0004618"(phosphoglycerate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006096"(glycolytic process)|go:"GO:0016310"(phosphorylation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031639"(plasminogen activation)|go:"GO:0043531"(ADP binding)|go:"GO:0045121"(membrane raft)|go:"GO:0047134"("protein-disulfide reductase (NAD(P)) activity")|go:"GO:0071456"(cellular response to hypoxia)|interpro:IPR001576(Phosphoglycerate kinase)|interpro:IPR015824(Phosphoglycerate kinase, N-terminal)|interpro:IPR015911(Phosphoglycerate kinase, conserved site)|interpro:IPR036043|mint:P09411|rcsb pdb:4O3F|reactome:R-MMU-70171|reactome:R-MMU-70263	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:388hPtU1n0xYbopG53ZWslYTzuk10090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q61171	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-444957|uniprotkb:O88376|uniprotkb:Q60796|uniprotkb:Q9CWJ4|uniprotkb:Q9DB49|ensembl:ENSMUSP00000005292|ensembl:ENSMUSP00000105355|ensembl:ENSMUSP00000105356|ensembl:ENSMUSP00000126451	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:prdx2_mouse(display_long)|uniprotkb:Thioredoxin-dependent peroxiredoxin 2(gene name synonym)|uniprotkb:Thioredoxin peroxidase 1(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxide reductase 1(gene name synonym)|uniprotkb:Thiol-specific antioxidant protein(gene name synonym)|uniprotkb:Prdx2(gene name)|psi-mi:Prdx2(display_short)|uniprotkb:Tdpx1(gene name synonym)|uniprotkb:Tpx(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_035693.3|go:"GO:0042098"(T cell proliferation)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043209"(myelin sheath)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045321"(leukocyte activation)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045581"(negative regulation of T cell differentiation)|go:"GO:0048538"(thymus development)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR024706|interpro:IPR036249|mint:Q61171|reactome:R-MMU-3299685|reactome:R-MMU-5628897|go:"GO:0034599"(cellular response to oxidative stress)|refseq:NP_001304314.1|ensembl:ENSMUSG00000005161(gene)|ensembl:ENSMUST00000005292(transcript)|ensembl:ENSMUST00000109733(transcript)|ensembl:ENSMUST00000109734(transcript)|ensembl:ENSMUST00000164807(transcript)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0002536"(respiratory burst involved in inflammatory response)|go:"GO:0004601"(peroxidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0008430"(selenium binding)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0016209"(antioxidant activity)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0031665"(negative regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:P1NxwIOnv1n4sNzQWtFjy2znSbA10090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q9DBJ1	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634789|uniprotkb:Q9D6W0|uniprotkb:Q9ERT3|ensembl:ENSMUSP00000011896	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:pgam1_mouse(display_long)|uniprotkb:Pgam1(gene name)|psi-mi:Pgam1(display_short)|uniprotkb:Phosphoglycerate mutase isozyme B(gene name synonym)|uniprotkb:BPG-dependent PGAM 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_075907.2|ensembl:ENSMUSG00000011752(gene)|ensembl:ENSMUST00000011896(transcript)|go:"GO:0004082"(bisphosphoglycerate mutase activity)|go:"GO:0004619"(phosphoglycerate mutase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006096"(glycolytic process)|go:"GO:0006110"(regulation of glycolytic process)|go:"GO:0016787"(hydrolase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043456"(regulation of pentose-phosphate shunt)|go:"GO:0045730"(respiratory burst)|interpro:IPR001345(Phosphoglycerate/bisphosphoglycerate mutase)|interpro:IPR005952(Phosphoglycerate mutase 1)|interpro:IPR013078(Phosphoglycerate mutase)|interpro:IPR029033|mint:Q9DBJ1|reactome:R-MMU-6798695|reactome:R-MMU-70171|reactome:R-MMU-70263	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:yXIwDvILEZUyPCtOTpZy0JxclWg10090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P02088	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-494201|uniprotkb:Q54AI0|uniprotkb:Q91V86|uniprotkb:Q9CRZ2|uniprotkb:Q9CXH5|uniprotkb:Q9CY12|uniprotkb:Q9CY54|uniprotkb:Q9R0S6	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:hbb1_mouse(display_long)|uniprotkb:Hemoglobin beta-1 chain(gene name synonym)|uniprotkb:Beta-1-globin(gene name synonym)|uniprotkb:Hemoglobin beta-major chain(gene name synonym)|uniprotkb:Hbb-b1(gene name)|psi-mi:Hbb-b1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_001188320.1|refseq:NP_032246.2|interpro:IPR009050(Globin-like)|interpro:IPR000971(Globin, subset)|interpro:IPR002337(Haemoglobin, beta)|interpro:IPR012292(Globin)|refseq:NP_001265090.1|go:"GO:0005344"(oxygen carrier activity)|go:"GO:0005833"(hemoglobin complex)|go:"GO:0010999"(regulation of eIF2 alpha phosphorylation by heme)|go:"GO:0015671"(oxygen transport)|go:"GO:0019825"(oxygen binding)|go:"GO:0020037"(heme binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0031721"(hemoglobin alpha binding)|go:"GO:0031838"(haptoglobin-hemoglobin complex)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0043177"(organic acid binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0046872"(metal ion binding)|go:"GO:0048821"(erythrocyte development)|go:"GO:0098869"(cellular oxidant detoxification)|rcsb pdb:1JEB|rcsb pdb:3HRW|mint:P02088	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:/W1Bo3qzhsm3Fzb/joImMwzE/Dg10090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q9QUI0	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-643583|uniprotkb:O88336|ensembl:ENSMUSP00000007959	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:rhoa_mouse(display_long)|uniprotkb:Rhoa(gene name)|psi-mi:Rhoa(display_short)|uniprotkb:Arha(gene name synonym)|uniprotkb:Arha2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_058082.2|refseq:NP_001300890.1|refseq:NP_001300891.1|ensembl:ENSMUST00000007959(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001822"(kidney development)|go:"GO:0001998"(angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure)|go:"GO:0002363"(alpha-beta T cell lineage commitment)|go:"GO:0003100"(regulation of systemic arterial blood pressure by endothelin)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007266"(Rho protein signal transduction)|ensembl:ENSMUSG00000007815(gene)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0030496"(midbody)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031098"(stress-activated protein kinase signaling cascade)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0009749"(response to glucose)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031982"(vesicle)|go:"GO:0032154"(cleavage furrow)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0033144"(negative regulation of intracellular steroid hormone receptor signaling pathway)|go:"GO:0033688"(regulation of osteoblast proliferation)|go:"GO:0034329"(cell junction assembly)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035385"(Roundabout signaling pathway)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0038027"(apolipoprotein A-I-mediated signaling pathway)|go:"GO:0042476"(odontogenesis)|go:"GO:0042493"|go:"GO:0042995"(cell projection)|go:"GO:0016020"(membrane)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043197"(dendritic spine)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043296"(apical junction complex)|go:"GO:0043297"(apical junction assembly)|go:"GO:0016477"(cell migration)|go:"GO:0017022"(myosin binding)|go:"GO:0019003"(GDP binding)|go:"GO:0043366"(beta selection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045471"(response to ethanol)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0097498"(endothelial tube lumen extension)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:1902766"(skeletal muscle satellite cell migration)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903673"(mitotic cleavage furrow formation)|go:"GO:1904695"(positive regulation of vascular associated smooth muscle contraction)|go:"GO:0046039"(GTP metabolic process)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|go:"GO:0048812"(neuron projection morphogenesis)|mint:Q9QUI0|rcsb pdb:4F38|reactome:R-MMU-114604|reactome:R-MMU-193634|reactome:R-MMU-198203|reactome:R-MMU-209563|reactome:R-MMU-2173791|reactome:R-MMU-392451|reactome:R-MMU-3928662|reactome:R-MMU-3928663|reactome:R-MMU-4086400|reactome:R-MMU-416482|go:"GO:0050773"(regulation of dendrite development)|reactome:R-MMU-416550|reactome:R-MMU-416572|reactome:R-MMU-4420097|reactome:R-MMU-5625740|reactome:R-MMU-5625900|reactome:R-MMU-5625970|reactome:R-MMU-5627117|reactome:R-MMU-5663220|reactome:R-MMU-5666185|reactome:R-MMU-5689896|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|reactome:R-MMU-6785631|go:"GO:0051384"(response to glucocorticoid)|reactome:R-MMU-6798695|go:"GO:0051496"(positive regulation of stress fiber assembly)|reactome:R-MMU-8849471|reactome:R-MMU-8980692|reactome:R-MMU-8985586|reactome:R-MMU-9013106|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0060193"(positive regulation of lipase activity)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061383"(trabecula morphogenesis)|dip:DIP-29984N	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:HKBQaI187g5GnvTF9bilOaiTaXM10090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P05201	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-494448|intact:EBI-2308970|uniprotkb:Q3UJH8|ensembl:ENSMUSP00000026196	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:aatc_mouse(display_long)|uniprotkb:Transaminase A(gene name synonym)|uniprotkb:Glutamate oxaloacetate transaminase 1(gene name synonym)|uniprotkb:Cysteine aminotransferase, cytoplasmic(gene name synonym)|uniprotkb:Cysteine transaminase, cytoplasmic(gene name synonym)|uniprotkb:Got1(gene name)|psi-mi:Got1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_034454.2|go:"GO:0004069"("L-aspartate:2-oxoglutarate aminotransferase activity")|go:"GO:0004609"(phosphatidylserine decarboxylase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0006107"(oxaloacetate metabolic process)|go:"GO:0006114"(glycerol biosynthetic process)|go:"GO:0006531"(aspartate metabolic process)|go:"GO:0006532"(aspartate biosynthetic process)|go:"GO:0006533"(aspartate catabolic process)|go:"GO:0006536"(glutamate metabolic process)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0019550"(glutamate catabolic process to aspartate)|go:"GO:0019551"(glutamate catabolic process to 2-oxoglutarate)|go:"GO:0030170"(pyridoxal phosphate binding)|ensembl:ENSMUSG00000025190(gene)|ensembl:ENSMUST00000026196(transcript)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031406"(carboxylic acid binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0043648"(dicarboxylic acid metabolic process)|go:"GO:0043679"(axon terminus)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0047801"(L-cysteine transaminase activity)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060290"(transdifferentiation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:1990267"(response to transition metal nanoparticle)|interpro:IPR000796(Aspartate/other aminotransferase)|interpro:IPR004838(Aminotransferases, class-I, pyridoxal-phosphate-binding site)|interpro:IPR004839(Aminotransferase, class I and II)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|mint:P05201|reactome:R-MMU-70263|reactome:R-MMU-8963693	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:4if14ijxqySSUHcJ2S2EXDyBzZQ10090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q8VCT3	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634151|uniprotkb:Q3TX27|ensembl:ENSMUSP00000076564	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:ampb_mouse(display_long)|uniprotkb:Rnpep(gene name)|psi-mi:Rnpep(display_short)|uniprotkb:Arginine aminopeptidase(gene name synonym)|uniprotkb:Arginyl aminopeptidase(gene name synonym)|uniprotkb:Cytosol aminopeptidase IV(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_001153096.1|refseq:NP_663392.2|ensembl:ENSMUSG00000041926(gene)|ensembl:ENSMUST00000077340(transcript)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0030141"(secretory granule)|go:"GO:0042277"(peptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0050897"(cobalt ion binding)|go:"GO:0070006"(metalloaminopeptidase activity)|interpro:IPR001930(Peptidase M1, membrane alanine aminopeptidase)|interpro:IPR014782(Peptidase M1, membrane alanine aminopeptidase, N-terminal)|interpro:IPR015211(Peptidase M1, leukotriene A4 hydrolase, aminopeptidase C-terminal)|interpro:IPR015571(Peptidase M1, aminopeptidase B)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027268|interpro:IPR034015|interpro:IPR038502|interpro:IPR042097|mint:Q8VCT3	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:+LRAsaaRE8dCGHZ6F9f/6yyLg5M10090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P63038	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-299343|ensembl:ENSMUSP00000027123|uniprotkb:P19226|uniprotkb:P19227|uniprotkb:P97602|uniprotkb:Q3KQP2|uniprotkb:Q3UIP0|uniprotkb:Q8C2C7|uniprotkb:Q8VEF4	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:ch60_mouse(display_long)|uniprotkb:Hspd1(gene name)|psi-mi:Hspd1(display_short)|uniprotkb:Hsp60(gene name synonym)|uniprotkb:Heat shock protein 60(gene name synonym)|uniprotkb:60 kDa chaperonin(gene name synonym)|uniprotkb:Chaperonin 60(gene name synonym)|uniprotkb:Mitochondrial matrix protein P1(gene name synonym)|uniprotkb:HSP-65(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	ensembl:ENSMUSG00000025980(gene)|ensembl:ENSMUST00000027123(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002039"(p53 binding)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0002842"(positive regulation of T cell mediated immune response to tumor cell)|go:"GO:0002931"(response to ischemia)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005769"(early endosome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006457"(protein folding)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009409"(response to cold)|go:"GO:0009986"(cell surface)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016853"(isomerase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030135"(coated vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033198"(response to ATP)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034514"(mitochondrial unfolded protein response)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042026"(protein refolding)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042588"(zymogen granule)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0045121"(membrane raft)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0048291"(isotype switching to IgG isotypes)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051087"(chaperone binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071866"(negative regulation of apoptotic process in bone marrow cell)|go:"GO:0097225"(sperm midpiece)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0140030"(modification-dependent protein binding)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|interpro:IPR001844(Chaperonin Cpn60)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR018370|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P63038|reactome:R-MMU-1268020|refseq:XP_006495769.1|refseq:NP_034607.3|dip:DIP-31396N	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:WD1fQLh4I0ovpakE8KtM1R0XpL410090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q9R257	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-494513|uniprotkb:O88814	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:hebp1_mouse(display_long)|uniprotkb:p22HBP(gene name synonym)|uniprotkb:Hebp1(gene name)|psi-mi:Hebp1(display_short)|uniprotkb:Hbp(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	interpro:IPR011256(Regulatory factor, effector, bacterial)|interpro:IPR006917(SOUL heme-binding protein)|refseq:NP_038574.3|mint:Q9R257|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0020037"(heme binding)|go:"GO:0042168"(heme metabolic process)|rcsb pdb:2GOV|rcsb pdb:2HVA|rcsb pdb:4A1M|reactome:R-MMU-418594|reactome:R-MMU-444473	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:0nbl+Dfr4jndpR8R4Z9FMXwm5XI10090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P49442	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634539|uniprotkb:Q8R3L1|ensembl:ENSMUSP00000027271	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:inpp_mouse(display_long)|uniprotkb:Inpp1(gene name)|psi-mi:Inpp1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:XP_011236743.1|refseq:XP_011236744.1|refseq:NP_032410.2|ensembl:ENSMUSG00000026102(gene)|ensembl:ENSMUST00000027271(transcript)|go:"GO:0004441"(inositol-1,4-bisphosphate 1-phosphatase activity)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046872"(metal ion binding)|interpro:IPR000760(Inositol monophosphatase)|interpro:IPR020550|interpro:IPR020583|mint:P49442|reactome:R-MMU-1855183	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:t4RFuD+wu56aRQUDA+4C1AruITQ10090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:O54786	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634519|uniprotkb:O54787|uniprotkb:Q8BQC7|uniprotkb:B2KFX0|ensembl:ENSMUSP00000030816	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:dffa_mouse(display_long)|uniprotkb:Dffa(gene name)|psi-mi:Dffa(display_short)|uniprotkb:Icad(gene name synonym)|uniprotkb:DNA fragmentation factor 45 kDa subunit(gene name synonym)|uniprotkb:Inhibitor of CAD(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_001020467.1|ensembl:ENSMUSG00000028974(gene)|ensembl:ENSMUST00000030816(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032076"(negative regulation of deoxyribonuclease activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0060703"(deoxyribonuclease inhibitor activity)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070242"(thymocyte apoptotic process)|go:"GO:1900118"(negative regulation of execution phase of apoptosis)|go:"GO:1902511"(negative regulation of apoptotic DNA fragmentation)|interpro:IPR003508(Caspase-activated nuclease CIDE-N)|interpro:IPR015121(DNA Fragmentation factor 45kDa, C terminal)|interpro:IPR017299(DNA fragmentation factor, alpha subunit)|interpro:IPR027296|rcsb pdb:1F2R|reactome:R-MMU-140342	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:MVg3+6pxmmcKBjFz1apoG3Di0Ig10090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P40936	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634510|uniprotkb:Q9CZ50|ensembl:ENSMUSP00000003569	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:inmt_mouse(display_long)|uniprotkb:Inmt(gene name)|psi-mi:Inmt(display_short)|uniprotkb:Temt(gene name synonym)|uniprotkb:Aromatic alkylamine N-methyltransferase(gene name synonym)|uniprotkb:Thioether S-methyltransferase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_033375.1|ensembl:ENSMUSG00000003477(gene)|ensembl:ENSMUST00000003569(transcript)|go:"GO:0004790"(thioether S-methyltransferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0008170"(N-methyltransferase activity)|go:"GO:0009308"(amine metabolic process)|go:"GO:0009636"(response to toxic substance)|go:"GO:0030748"(amine N-methyltransferase activity)|go:"GO:0032259"(methylation)|go:"GO:0098615"(dimethyl selenide methyltransferase activity)|go:"GO:0102707"("S-adenosyl-L-methionine:beta-alanine N-methyltransferase activity")|interpro:IPR000940(Methyltransferase, NNMT/PNMT/TEMT)|interpro:IPR025820|interpro:IPR029063|mint:P40936	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:K/ppFCWhzvqMB6eI89nV+gbmR8E10090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P61979	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-299907|ensembl:ENSMUSP00000039269|uniprotkb:Q07244|uniprotkb:Q15671|uniprotkb:Q60577|uniprotkb:Q8BGQ8|uniprotkb:Q922Y7|uniprotkb:Q96J62	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:hnrpk_mouse(display_long)|uniprotkb:Hnrnpk(gene name)|psi-mi:Hnrnpk(display_short)|uniprotkb:Hnrpk(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	ensembl:ENSMUST00000043269(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0002102"(podosome)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010988"(regulation of low-density lipoprotein particle clearance)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|ensembl:ENSMUSG00000021546(gene)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0042802"(identical protein binding)|go:"GO:0042805"(actinin binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043679"(axon terminus)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0030628"(pre-mRNA 3'-splice site binding)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1905599"(positive regulation of low-density lipoprotein receptor activity)|go:"GO:1990715"(mRNA CDS binding)|go:"GO:1990829"(C-rich single-stranded DNA binding)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000173"(negative regulation of branching morphogenesis of a nerve)|interpro:IPR004087(K Homology)|go:"GO:0051117"(ATPase binding)|go:"GO:0060999"(positive regulation of dendritic spine development)|interpro:IPR004088(K Homology, type 1)|interpro:IPR012987(ROK, N-terminal)|interpro:IPR033090|interpro:IPR036612|mint:P61979|reactome:R-MMU-4570464|reactome:R-MMU-72163|reactome:R-MMU-72203|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1902165"(regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1904322"(cellular response to forskolin)|refseq:NP_001288269.1|refseq:NP_001288270.1|refseq:NP_001288272.1|refseq:NP_001288273.1|refseq:NP_001288274.1|refseq:XP_017170884.1|refseq:XP_017170885.1|refseq:NP_079555.1|refseq:XP_006517166.1|refseq:XP_006517167.1	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:YZQD5JJkHPUMtZ4XUA9fQkNfXzc10090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q9CPU0	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634565|uniprotkb:Q543L3|uniprotkb:Q8R3T1|ensembl:ENSMUSP00000126586|ensembl:ENSMUSP00000157858|ensembl:ENSMUSP00000158296	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:lgul_mouse(display_long)|uniprotkb:Glo1(gene name)|psi-mi:Glo1(display_short)|uniprotkb:Methylglyoxalase(gene name synonym)|uniprotkb:Aldoketomutase(gene name synonym)|uniprotkb:Glyoxalase I(gene name synonym)|uniprotkb:Ketone-aldehyde mutase(gene name synonym)|uniprotkb:S-D-lactoylglutathione methylglyoxal lyase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_001107032.1|refseq:NP_079650.3|ensembl:ENSMUSG00000024026(gene)|ensembl:ENSMUST00000167624(transcript)|ensembl:ENSMUST00000235547(transcript)|ensembl:ENSMUST00000236335(transcript)|go:"GO:0004462"(lactoylglutathione lyase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009438"(methylglyoxal metabolic process)|go:"GO:0019243"(methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0043066"(negative regulation of apoptotic process)|interpro:IPR004360(Glyoxalase/bleomycin resistance protein/dioxygenase)|interpro:IPR004361(Glyoxalase I)|interpro:IPR018146|interpro:IPR029068|interpro:IPR037523|mint:Q9CPU0|rcsb pdb:2ZA0|rcsb pdb:4KYH|rcsb pdb:4KYK|rcsb pdb:4OPN|rcsb pdb:4PV5|rcsb pdb:4X2A|rcsb pdb:6L0U|reactome:R-MMU-70268	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:7jeziqaOzbREOjGCcMO1ZLNZjCs10090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P58044	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634555|uniprotkb:Q4FJU2	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:idi1_mouse(display_long)|uniprotkb:Idi1(gene name)|psi-mi:Idi1(display_short)|uniprotkb:Isopentenyl pyrophosphate isomerase 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_663335.2|interpro:IPR011876(Isopentenyl-diphosphate delta-isomerase, type 1)|interpro:IPR000086(NUDIX hydrolase, core)|interpro:IPR015797(NUDIX)|refseq:XP_006498576.1|mint:P58044|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004452"(isopentenyl-diphosphate delta-isomerase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0008299"(isoprenoid biosynthetic process)|go:"GO:0009240"(isopentenyl diphosphate biosynthetic process)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030145"(manganese ion binding)|go:"GO:0035634"(response to stilbenoid)|go:"GO:0050992"(dimethylallyl diphosphate biosynthetic process)|reactome:R-MMU-191273	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:Qp970BUlfykYEclI2FgPjVNtYt010090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q61233	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-309345|uniprotkb:Q3UE24|uniprotkb:Q8R1X3|uniprotkb:Q9CV77|ensembl:ENSMUSP00000116271|ensembl:ENSMUSP00000117137|ensembl:ENSMUSP00000121201	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:plsl_mouse(display_long)|uniprotkb:Lcp1(gene name)|psi-mi:Lcp1(display_short)|uniprotkb:Pls2(gene name synonym)|uniprotkb:L-plastin(gene name synonym)|uniprotkb:Lymphocyte cytosolic protein 1(gene name synonym)|uniprotkb:65 kDa macrophage protein(gene name synonym)|uniprotkb:pp65(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_032905.2|refseq:XP_006518762.1|refseq:XP_006518764.1|refseq:XP_006518765.1|refseq:XP_006518766.1|refseq:XP_006518767.1|refseq:NP_001234913.1|go:"GO:0009611"(response to wounding)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030175"(filopodium)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0032432"(actin filament bundle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051020"(GTPase binding)|go:"GO:0051639"(actin filament network formation)|go:"GO:0071803"(positive regulation of podosome assembly)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR036872|interpro:IPR039956|interpro:IPR039959|mint:Q61233|ensembl:ENSMUSG00000021998(gene)|ensembl:ENSMUST00000124499(transcript)|ensembl:ENSMUST00000131802(transcript)|ensembl:ENSMUST00000145303(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002102"(podosome)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|refseq:XP_017171409.1	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:kU9t6rNcFG1BiDoIuP1LuaUYl7I10090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P08249	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-773487|uniprotkb:Q0QF44|uniprotkb:Q8CF79|uniprotkb:Q8R1P0|ensembl:ENSMUSP00000019323	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:mdhm_mouse(display_long)|uniprotkb:Mdh2(gene name)|psi-mi:Mdh2(display_short)|uniprotkb:Mor1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_032643.2|ensembl:ENSMUSG00000019179(gene)|ensembl:ENSMUST00000019323(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006107"(oxaloacetate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0009060"(aerobic respiration)|go:"GO:0016020"(membrane)|go:"GO:0016615"(malate dehydrogenase activity)|go:"GO:0030060"(L-malate dehydrogenase activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043209"(myelin sheath)|go:"GO:0043621"(protein self-association)|go:"GO:0046554"("malate dehydrogenase (NADP+) activity")|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001252(Malate dehydrogenase, active site)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR010097(Malate dehydrogenase, NAD-dependent, eukaryotes and gamma proteobacteria)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR022383|interpro:IPR036291|mint:P08249|reactome:R-MMU-70263|reactome:R-MMU-71403	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:KG/ilme6qKXuXKp3BqXC5kQ0dM410090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:O08677	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-738531|uniprotkb:O08676|uniprotkb:Q91XK5|uniprotkb:Q32MX7|uniprotkb:Q6S9I1	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:kng1_mouse(display_long)|uniprotkb:Kng1(gene name)|psi-mi:Kng1(display_short)|uniprotkb:Kng(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	interpro:IPR027358|refseq:NP_001095881.1|refseq:NP_075614.1|interpro:IPR002395(HMW kininogen)|interpro:IPR000010(Proteinase inhibitor I25, cystatin)|interpro:IPR018073|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007596"(blood coagulation)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0042311"(vasodilation)|go:"GO:0062023"(collagen-containing extracellular matrix)|mint:O08677	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:b3fkbWY+mVAwNAWfKdrAYPU2dtM10090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P11352	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634398|uniprotkb:P12079|uniprotkb:Q544W3|uniprotkb:Q5RJH8|uniprotkb:Q9CR54|ensembl:ENSMUSP00000081010	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:gpx1_mouse(display_long)|uniprotkb:Gpx1(gene name)|psi-mi:Gpx1(display_short)|uniprotkb:Cellular glutathione peroxidase(gene name synonym)|uniprotkb:Selenium-dependent glutathione peroxidase 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_032186.2|refseq:NP_001316456.1|refseq:NP_001316457.1|ensembl:ENSMUSG00000063856(gene)|ensembl:ENSMUST00000082429(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001885"(endothelial cell development)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004601"(peroxidase activity)|go:"GO:0004602"(glutathione peroxidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009410"(response to xenobiotic stimulus)|go:"GO:0009609"(response to symbiotic bacterium)|go:"GO:0009611"(response to wounding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009650"(UV protection)|go:"GO:0010269"(response to selenium ion)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014902"(myotube differentiation)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018158"(protein oxidation)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019372"(lipoxygenase pathway)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0033599"(regulation of mammary gland epithelial cell proliferation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042311"(vasodilation)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0047066"(phospholipid-hydroperoxide glutathione peroxidase activity)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051450"(myoblast proliferation)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060047"(heart contraction)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097413"(Lewy body)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR000889(Glutathione peroxidase)|interpro:IPR029759|interpro:IPR029760|interpro:IPR036249|mint:P11352|reactome:R-MMU-2142712|reactome:R-MMU-2142770|reactome:R-MMU-3299685	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:FMVzTijk5Rl8jk6oQftS6S5y0VI10090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P02089	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-494213|uniprotkb:Q5D0E8	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:hbb2_mouse(display_long)|uniprotkb:Hemoglobin beta-2 chain(gene name synonym)|uniprotkb:Beta-2-globin(gene name synonym)|uniprotkb:Hemoglobin beta-minor chain(gene name synonym)|uniprotkb:Hbb-b2(gene name)|psi-mi:Hbb-b2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	interpro:IPR009050(Globin-like)|interpro:IPR000971(Globin, subset)|interpro:IPR002337(Haemoglobin, beta)|refseq:NP_058652.1|interpro:IPR012292(Globin)|go:"GO:0005344"(oxygen carrier activity)|go:"GO:0005833"(hemoglobin complex)|go:"GO:0019825"(oxygen binding)|go:"GO:0020037"(heme binding)|go:"GO:0031721"(hemoglobin alpha binding)|go:"GO:0031838"(haptoglobin-hemoglobin complex)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0043177"(organic acid binding)|go:"GO:0045639"(positive regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048821"(erythrocyte development)|go:"GO:0098869"(cellular oxidant detoxification)|rcsb pdb:1FNE|rcsb pdb:1FNG|rcsb pdb:1I3R|mint:P02089	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:5t7MUKklDto4E5kgtOvSP8i82vU10090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q99LB4	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634357|ensembl:ENSMUSP00000063389|ensembl:ENSMUSP00000109705|ensembl:ENSMUSP00000109706	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:q99lb4_mouse(display_long)|uniprotkb:Capg(gene name)|psi-mi:Capg(display_short)|uniprotkb:Actin regulatory protein CAP-G(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_001035999.1|refseq:NP_031625.2|interpro:IPR029917|mint:Q99LB4|ensembl:ENSMUSG00000056737(gene)|ensembl:ENSMUST00000071044(transcript)|ensembl:ENSMUST00000114071(transcript)|ensembl:ENSMUST00000114072(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005814"(centriole)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0042470"(melanosome)|go:"GO:0051014"(actin filament severing)|go:"GO:0051015"(actin filament binding)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090543"(Flemming body)|interpro:IPR007122(Gelsolin)|interpro:IPR007123(Gelsolin region)|interpro:IPR029006|refseq:XP_017176859.1|refseq:NP_001258324.1|refseq:NP_001258344.1	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:xtrYWghc5oYAYCNxkaM0S/ym//s10090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P10649	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634409|uniprotkb:Q58ET5|uniprotkb:A2AE90|ensembl:ENSMUSP00000004140	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:gstm1_mouse(display_long)|uniprotkb:Gstm1(gene name)|psi-mi:Gstm1(display_short)|uniprotkb:GST class-mu 1(gene name synonym)|uniprotkb:Glutathione S-transferase GT8.7(gene name synonym)|uniprotkb:pmGT10(gene name synonym)|uniprotkb:GST 1-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_034488.1|ensembl:ENSMUSG00000058135(gene)|ensembl:ENSMUST00000004140(transcript)|go:"GO:0004364"(glutathione transferase activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0016151"(nickel cation binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035690"|go:"GO:0042178"(xenobiotic catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043295"(glutathione binding)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051122"(hepoxilin biosynthetic process)|go:"GO:1901687"(glutathione derivative biosynthetic process)|interpro:IPR003081(Glutathione S-transferase, Mu class)|interpro:IPR004045(Glutathione S-transferase, N-terminal)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR036249|interpro:IPR036282|interpro:IPR040079|mint:P10649|reactome:R-MMU-156590	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:xeAbOCB4xSUYljqfMdyAw61x6Ao10090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P17182	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-299507|ensembl:ENSMUSP00000075513|ensembl:ENSMUSP00000079727|ensembl:ENSMUSP00000157807|uniprotkb:Q99KT7|uniprotkb:Q9DCY7	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:enoa_mouse(display_long)|uniprotkb:Eno1(gene name)|psi-mi:Eno1(display_short)|uniprotkb:Eno-1(gene name synonym)|uniprotkb:2-phospho-D-glycerate hydro-lyase(gene name synonym)|uniprotkb:Non-neural enolase(gene name synonym)|uniprotkb:Enolase 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	ensembl:ENSMUSG00000059040(gene)|ensembl:ENSMUSG00000063524(gene)|ensembl:ENSMUST00000076155(transcript)|ensembl:ENSMUST00000080926(transcript)|ensembl:ENSMUST00000235307(transcript)|go:"GO:0000015"(phosphopyruvate hydratase complex)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003723"(RNA binding)|go:"GO:0004634"(phosphopyruvate hydratase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006096"(glycolytic process)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030426"(growth cone)|go:"GO:0032889"(regulation of vacuole fusion, non-autophagic)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043209"(myelin sheath)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0051020"(GTPase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0051099"(positive regulation of binding)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0099738"(cell cortex region)|interpro:IPR000941(Enolase)|interpro:IPR020809|interpro:IPR020810|interpro:IPR020811|interpro:IPR029017|interpro:IPR036849|mint:P17182|reactome:R-MMU-70171|reactome:R-MMU-70263|refseq:NP_001020559.1|refseq:NP_075608.2|refseq:XP_006538588.2	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:YFpn/7GDB6vXgCYLSxvNns7FlT410090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P21550	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634301|ensembl:ENSMUSP00000072620|ensembl:ENSMUSP00000104188|ensembl:ENSMUSP00000128714	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:enob_mouse(display_long)|uniprotkb:Eno3(gene name)|psi-mi:Eno3(display_short)|uniprotkb:Eno-3(gene name synonym)|uniprotkb:2-phospho-D-glycerate hydro-lyase(gene name synonym)|uniprotkb:Muscle-specific enolase(gene name synonym)|uniprotkb:Skeletal muscle enolase(gene name synonym)|uniprotkb:Enolase 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_001129534.1|refseq:NP_031959.1|refseq:NP_001263214.1|refseq:XP_006532225.1|ensembl:ENSMUSG00000060600(gene)|ensembl:ENSMUST00000072841(transcript)|ensembl:ENSMUST00000108548(transcript)|ensembl:ENSMUST00000170716(transcript)|go:"GO:0000015"(phosphopyruvate hydratase complex)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004634"(phosphopyruvate hydratase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006096"(glycolytic process)|go:"GO:0007568"(aging)|go:"GO:0016020"(membrane)|go:"GO:0032889"(regulation of vacuole fusion, non-autophagic)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR000941(Enolase)|interpro:IPR020809|interpro:IPR020810|interpro:IPR020811|interpro:IPR029017|interpro:IPR036849|mint:P21550|reactome:R-MMU-70171|reactome:R-MMU-70263	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:CN/5EMhCFqpjAxZ04UHwcLN+eRI10090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P07724	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1183810|uniprotkb:Q3TV03|uniprotkb:Q61802|uniprotkb:Q8C7C7|uniprotkb:Q8C7H3|uniprotkb:Q8CG74|ensembl:ENSMUSP00000031314	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:albu_mouse(display_long)|uniprotkb:Alb(gene name)|psi-mi:Alb(display_short)|uniprotkb:Alb1(gene name synonym)|uniprotkb:Alb-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_033784.2|ensembl:ENSMUSG00000029368(gene)|ensembl:ENSMUST00000031314(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0015643"(toxic substance binding)|go:"GO:0019825"(oxygen binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043209"(myelin sheath)|go:"GO:0046010"(positive regulation of circadian sleep/wake cycle, non-REM sleep)|go:"GO:0051087"(chaperone binding)|go:"GO:0051659"(maintenance of mitochondrion location)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072341"(modified amino acid binding)|go:"GO:0140272"(exogenous protein binding)|go:"GO:1903981"(enterobactin binding)|interpro:IPR000264(Serum albumin)|interpro:IPR014760(Serum albumin, N-terminal)|interpro:IPR020857|interpro:IPR020858|interpro:IPR021177|mint:P07724|reactome:R-MMU-114608|reactome:R-MMU-159418|reactome:R-MMU-189451|reactome:R-MMU-189483|reactome:R-MMU-2168880|reactome:R-MMU-381426|reactome:R-MMU-879518|reactome:R-MMU-8957275|reactome:R-MMU-8964058|reactome:R-MMU-9707564	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:R7zO/mB332rAl8J+WrXfsHzjSYs10090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P17183	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634308|ensembl:ENSMUSP00000004378	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:enog_mouse(display_long)|uniprotkb:Eno2(gene name)|psi-mi:Eno2(display_short)|uniprotkb:Eno-2(gene name synonym)|uniprotkb:2-phospho-D-glycerate hydro-lyase(gene name synonym)|uniprotkb:Neural enolase(gene name synonym)|uniprotkb:Neuron-specific enolase(gene name synonym)|uniprotkb:Enolase 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_038537.1|refseq:NP_001289571.1|refseq:XP_006505566.1|refseq:XP_006505567.1|ensembl:ENSMUSG00000004267(gene)|ensembl:ENSMUST00000004378(transcript)|go:"GO:0000015"(phosphopyruvate hydratase complex)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0004634"(phosphopyruvate hydratase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006096"(glycolytic process)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030426"(growth cone)|go:"GO:0032889"(regulation of vacuole fusion, non-autophagic)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043209"(myelin sheath)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0097060"(synaptic membrane)|go:"GO:0099738"(cell cortex region)|interpro:IPR000941(Enolase)|interpro:IPR020809|interpro:IPR020810|interpro:IPR020811|interpro:IPR029017|interpro:IPR036849|mint:P17183|reactome:R-MMU-70171|reactome:R-MMU-70263	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:bEXS2/h1idLiCLtUPFHMwtCMV5I10090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q9WV92	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-911885|uniprotkb:Q69ZT8|ensembl:ENSMUSP00000079098|uniprotkb:Q9R102	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:e41l3_mouse(display_long)|uniprotkb:4.1B(gene name synonym)|uniprotkb:Differentially expressed in adenocarcinoma of the lung protein 1(gene name synonym)|uniprotkb:Epb41l3(gene name)|psi-mi:Epb41l3(display_short)|uniprotkb:Dal1(gene name synonym)|uniprotkb:Epb4.1l3(gene name synonym)|uniprotkb:Kiaa0987(gene name synonym)|uniprotkb:Erythrocyte membrane protein band 4.1-like 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	ensembl:ENSMUSG00000024044(gene)|ensembl:ENSMUST00000080208(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0002175"(protein localization to paranode region of axon)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006915"(apoptotic process)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030054"(cell junction)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030913"(paranodal junction assembly)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0033270"(paranode region of axon)|go:"GO:0043217"(myelin maintenance)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0071205"(protein localization to juxtaparanode region of axon)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0106006"(cytoskeletal protein-membrane anchor activity)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR007477(SAB)|interpro:IPR008379(Band 4.1, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR014847("FERM adjacent (FA)")|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR030691|interpro:IPR035963|mint:Q9WV92|reactome:R-MMU-6794361|refseq:NP_038841.1|refseq:XP_011244586.1|refseq:XP_011244591.1|refseq:XP_017172724.1|refseq:XP_017172725.1	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:51gkxiswTUqQbAUqjGoPthWD7jM10090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:O08749	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-773199|uniprotkb:Q3TG55|uniprotkb:Q3U5W5|uniprotkb:Q3UWP7|uniprotkb:Q99LD3|ensembl:ENSMUSP00000106481	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:dldh_mouse(display_long)|uniprotkb:Dihydrolipoamide dehydrogenase(gene name synonym)|uniprotkb:Dld(gene name)|psi-mi:Dld(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_031887.2|ensembl:ENSMUSG00000020664(gene)|ensembl:ENSMUST00000110857(transcript)|go:"GO:0004148"(dihydrolipoyl dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005929"(cilium)|go:"GO:0006086"(acetyl-CoA biosynthetic process from pyruvate)|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0006508"(proteolysis)|go:"GO:0007369"(gastrulation)|go:"GO:0007568"(aging)|go:"GO:0009106"(lipoate metabolic process)|go:"GO:0031514"(motile cilium)|go:"GO:0034604"("pyruvate dehydrogenase (NAD+) activity")|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043159"(acrosomal matrix)|go:"GO:0043209"(myelin sheath)|go:"GO:0043544"(lipoamide binding)|go:"GO:0045252"(oxoglutarate dehydrogenase complex)|go:"GO:0045254"(pyruvate dehydrogenase complex)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0048240"(sperm capacitation)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0051068"(dihydrolipoamide metabolic process)|go:"GO:0051287"(NAD binding)|go:"GO:0061732"(mitochondrial acetyl-CoA biosynthetic process from pyruvate)|go:"GO:0106077"(histone succinylation)|interpro:IPR001100(Pyridine nucleotide-disulphide oxidoreductase, class I)|interpro:IPR004099(Pyridine nucleotide-disulphide oxidoreductase, dimerisation)|interpro:IPR006258(Dihydrolipoamide dehydrogenase)|interpro:IPR012999(Pyridine nucleotide-disulphide oxidoreductase, class I, active site)|interpro:IPR016156(FAD/NAD-linked reductase, dimerisation)|interpro:IPR023753|interpro:IPR036188|mint:O08749|reactome:R-MMU-204174|reactome:R-MMU-389661|reactome:R-MMU-5362517|reactome:R-MMU-6783984|reactome:R-MMU-70268|reactome:R-MMU-70895|reactome:R-MMU-71064|reactome:R-MMU-71403	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:6j/8rw4lkNMW4Lo5sGoRdDJBk2w10090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P83917	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-78119|uniprotkb:P23197|ensembl:ENSMUSP00000091475	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:cbx1_mouse(display_long)|uniprotkb:Cbx1(gene name)|psi-mi:Cbx1(display_short)|uniprotkb:Cbx(gene name synonym)|uniprotkb:Heterochromatin protein 1 homolog beta(gene name synonym)|uniprotkb:Modifier 1 protein(gene name synonym)|uniprotkb:M31(gene name synonym)|uniprotkb:Heterochromatin protein p25(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	ensembl:ENSMUSG00000018666(gene)|ensembl:ENSMUST00000093943(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0001939"(female pronucleus)|go:"GO:0001940"(male pronucleus)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005819"(spindle)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010369"(chromocenter)|go:"GO:0019899"(enzyme binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0090734"(site of DNA damage)|go:"GO:1990226"(histone methyltransferase binding)|interpro:IPR000953(Chromo domain)|interpro:IPR008251(Chromo shadow)|interpro:IPR016197(Chromo domain-like)|interpro:IPR017984|interpro:IPR023779|interpro:IPR023780|mint:P83917|rcsb pdb:1AP0|rcsb pdb:1DZ1|rcsb pdb:1GUW|rcsb pdb:1S4Z|refseq:NP_031648.1|refseq:XP_006532162.1|refseq:XP_006532163.1|refseq:XP_011247006.1|refseq:XP_017169731.1|dip:DIP-30892N	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:W2npW/vFRcuTkStKpknsAP69q6I10090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:O88712	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-604547|ensembl:ENSMUSP00000078682|uniprotkb:Q3TAT1|uniprotkb:Q3TDL5|uniprotkb:Q3TUM5|uniprotkb:Q91WI6|uniprotkb:Q91YX3|uniprotkb:Q9QYG2	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:ctbp1_mouse(display_long)|uniprotkb:Ctbp1(gene name)|psi-mi:Ctbp1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	go:"GO:0017053"(transcription repressor complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0051287"(NAD binding)|go:"GO:0051726"(regulation of cell cycle)|ensembl:ENSMUSG00000037373(gene)|go:"GO:0090241"(negative regulation of histone H4 acetylation)|go:"GO:0098793"(presynapse)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099526"(presynapse to nucleus signaling pathway)|ensembl:ENSMUST00000079746(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR006139(D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region)|interpro:IPR006140(D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding)|interpro:IPR029752|go:"GO:0003682"(chromatin binding)|interpro:IPR029753|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|interpro:IPR036291|go:"GO:0005737"(cytoplasm)|interpro:IPR043322|go:"GO:0006342"|mint:O88712|reactome:R-MMU-3769402|reactome:R-MMU-3899300|reactome:R-MMU-4641265|go:"GO:0008134"(transcription factor binding)|go:"GO:0016616"(oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)|refseq:NP_001185788.1|refseq:NP_001185789.1|refseq:NP_001185790.1|refseq:NP_038530.1|refseq:NP_001297464.1|dip:DIP-33907N	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:l2rq9ypazCscM/WbocEKgQZcEBo10090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q6PFA2	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634219|ensembl:ENSMUSP00000103478|ensembl:ENSMUSP00000127344	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:q6pfa2_mouse(display_long)|uniprotkb:Clta(gene name)|psi-mi:Clta(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_001277399.1|refseq:NP_001073853.1|refseq:XP_006537653.1|ensembl:ENSMUSG00000028478(gene)|ensembl:ENSMUST00000107846(transcript)|ensembl:ENSMUST00000170241(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|interpro:IPR000996(Clathrin light chain)	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:LlnRbz6pNaDbFGKo/zVtbVKYdms10090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P62204	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-397460|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q3TEH7|uniprotkb:Q3THK5|uniprotkb:Q3U6Z5|uniprotkb:Q3U7C7|uniprotkb:Q498A3|uniprotkb:Q61379|uniprotkb:Q61380|uniprotkb:Q8BNC9|uniprotkb:Q91VQ9|uniprotkb:Q9D6G4|dip:DIP-31550N|uniprotkb:P0DP26|uniprotkb:P0DP28	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:calm_mouse(display_long)|uniprotkb:Calm1(gene name)|psi-mi:Calm1(display_short)|uniprotkb:Calm(gene name synonym)|uniprotkb:Cam1(gene name synonym)|uniprotkb:Calm2(gene name)|psi-mi:Calm2(display_short)|uniprotkb:Cam2(gene name synonym)|uniprotkb:Camb(gene name synonym)|uniprotkb:Calm3(gene name)|psi-mi:Calm3(display_short)|uniprotkb:Cam3(gene name synonym)|uniprotkb:Camc(gene name synonym)|uniprotkb:Cam(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	rcsb pdb:3WFN|rcsb pdb:4HEX|go:"GO:0005509"(calcium ion binding)|go:"GO:0000922"(spindle pole)|refseq:NP_031615.1|refseq:NP_031616.1|refseq:NP_033920.1|rcsb pdb:2IX7|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|rcsb pdb:2DFS|refseq:NP_001300863.1|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0043388"(positive regulation of DNA binding)|reactome:R-MMU-2672351|reactome:R-MMU-418359|reactome:R-MMU-425561|reactome:R-MMU-5578775|reactome:R-MMU-936837|go:"GO:0005829"(cytosol)|reactome:R-MMU-8876725|rcsb pdb:4E50|rcsb pdb:4E53|go:"GO:0061024"(membrane organization)|rcsb pdb:4ZLK|reactome:R-MMU-1445148|reactome:R-MMU-5576892|ensembl:ENSMUST00000019514|ensembl:ENSMUST00000040440|ensembl:ENSMUST00000110082|reactome:R-MMU-111932|reactome:R-MMU-111933|reactome:R-MMU-111957|reactome:R-MMU-114608|reactome:R-MMU-1474151|reactome:R-MMU-1855204|reactome:R-MMU-203615|reactome:R-MMU-2871809|reactome:R-MMU-4086398|reactome:R-MMU-442717|reactome:R-MMU-442729|reactome:R-MMU-442745|reactome:R-MMU-442982|reactome:R-MMU-445355|reactome:R-MMU-451308|reactome:R-MMU-5607763|reactome:R-MMU-5626467|reactome:R-MMU-5218920|reactome:R-MMU-5627123|reactome:R-MMU-5673001|reactome:R-MMU-70221|ensembl:ENSMUSG00000001175|ensembl:ENSMUSG00000019370|ensembl:ENSMUSG00000036438|ensembl:ENSMUSP00000019514|ensembl:ENSMUSP00000048857|ensembl:ENSMUSP00000105709|reactome:R-MMU-2514859|reactome:R-MMU-163615|go:"GO:0034704"(calcium channel complex)|go:"GO:0005813"(centrosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030426"(growth cone)|go:"GO:0005634"(nucleus)|go:"GO:0030017"(sarcomere)|go:"GO:0005876"(spindle microtubule)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0002027"(regulation of heart rate)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0001975"(response to amphetamine)|go:"GO:0051412"(response to corticosterone)|go:"GO:0021762"(substantia nigra development)|rcsb pdb:1UP5|go:"GO:1902494"(catalytic complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0043209"(myelin sheath)|go:"GO:0014069"(postsynaptic density)|go:"GO:0043234"|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031432"(titin binding)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0030819"(obsolete positive regulation of cAMP biosynthetic process)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|reactome:R-MMU-2025928|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0005886"(plasma membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031997"(N-terminal myristoylation domain binding)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0031800"(type 3 metabotropic glutamate receptor binding)|go:"GO:0090151"(establishment of protein localization to mitochondrial membrane)|go:"GO:0075206"(obsolete positive regulation by host of symbiont cAMP-mediated signal transduction)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:0051300"(spindle pole body organization)|interpro:IPR039030	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:tTYcOd9bOh211njZVz7cYVybAMQ10090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P68134	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-367520|uniprotkb:P02568|uniprotkb:P99020|ensembl:ENSMUSP00000034453	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:acts_mouse(display_long)|uniprotkb:Acta1(gene name)|psi-mi:Acta1(display_short)|uniprotkb:Acta(gene name synonym)|uniprotkb:Alpha-actin-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_033736.1|ensembl:ENSMUSG00000031972(gene)|ensembl:ENSMUST00000034453(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005865"(striated muscle thin filament)|go:"GO:0005869"(dynactin complex)|go:"GO:0005884"(actin filament)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009991"(response to extracellular stimulus)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030017"(sarcomere)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030240"(skeletal muscle thin filament assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043503"(skeletal muscle fiber adaptation)|go:"GO:0044297"(cell body)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0090131"(mesenchyme migration)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|interpro:IPR043129|mint:P68134|rcsb pdb:4B1U|rcsb pdb:6KLL|rcsb pdb:6KLN|rcsb pdb:7AQK|rcsb pdb:7NEP|reactome:R-MMU-390522|go:"GO:0001725"(stress fiber)|refseq:NP_001258970.1	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:2vZu8ElmMe+6GjKBliCAatNGZR410090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P14211	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-644340|ensembl:ENSMUSP00000003912|uniprotkb:Q3TVD2	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:calr_mouse(display_long)|uniprotkb:CRP55(gene name synonym)|uniprotkb:Calregulin(gene name synonym)|uniprotkb:HACBP(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 60(gene name synonym)|uniprotkb:Calr(gene name)|psi-mi:Calr(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_031617.1|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033018"(sarcoplasmic reticulum lumen)|go:"GO:0033144"(negative regulation of intracellular steroid hormone receptor signaling pathway)|go:"GO:0033574"(response to testosterone)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006457"(protein folding)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0042277"(peptide binding)|go:"GO:0042493"|go:"GO:0042562"(hormone binding)|go:"GO:0042824"(MHC class I peptide loading complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0007283"(spermatogenesis)|go:"GO:0060473"(cortical granule)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0090398"(cellular senescence)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901164"(negative regulation of trophoblast cell migration)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000510"(positive regulation of dendritic cell chemotaxis)|interpro:IPR001580(Calreticulin/calnexin)|interpro:IPR009033(Calreticulin/calnexin, P)|interpro:IPR009169(Calreticulin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|go:"GO:0008284"(positive regulation of cell population proliferation)|interpro:IPR018124|mint:P14211|rcsb pdb:3O0V|rcsb pdb:3O0W|rcsb pdb:3O0X|rcsb pdb:3RG0|go:"GO:0009897"(external side of plasma membrane)|reactome:R-MMU-1236974|reactome:R-MMU-3000480|reactome:R-MMU-901042|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|ensembl:ENSMUSG00000003814(gene)|ensembl:ENSMUST00000003912(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002502"(peptide antigen assembly with MHC class I protein complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005506"(iron ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|reactome:R-MMU-983170	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:/yN2nHI8x9rWoJO+b+2dYGxOgf010090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q04447	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634233|uniprotkb:Q3KQP4|uniprotkb:Q3TKI3|uniprotkb:Q3U5P5|uniprotkb:Q3UF71|uniprotkb:Q9CXK6|ensembl:ENSMUSP00000001304	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:kcrb_mouse(display_long)|uniprotkb:Ckb(gene name)|psi-mi:Ckb(display_short)|uniprotkb:Ckbb(gene name synonym)|uniprotkb:Creatine kinase B chain(gene name synonym)|uniprotkb:B-CK(gene name synonym)|uniprotkb:Creatine phosphokinase B-type(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_067248.1|ensembl:ENSMUSG00000001270(gene)|ensembl:ENSMUST00000001304(transcript)|go:"GO:0004111"(creatine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0016301"(kinase activity)|go:"GO:0021549"(cerebellum development)|go:"GO:0030425"(dendrite)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0046314"(phosphocreatine biosynthetic process)|interpro:IPR000749("ATP:guanido phosphotransferase")|interpro:IPR014746(Glutamine synthetase/guanido kinase, catalytic region)|interpro:IPR022413|interpro:IPR022414|interpro:IPR022415|interpro:IPR036802|mint:Q04447|reactome:R-MMU-71288|reactome:R-MMU-9696264	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:7r2Owq3p9g124vCs/sG4m8aScuU10090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P16045	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634185|uniprotkb:P05163|uniprotkb:P11946|uniprotkb:P17601|uniprotkb:Q4FZH4|uniprotkb:Q99M27|uniprotkb:Q9D0X0|ensembl:ENSMUSP00000086795	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:leg1_mouse(display_long)|uniprotkb:Lgals1(gene name)|psi-mi:Lgals1(display_short)|uniprotkb:Gbp(gene name synonym)|uniprotkb:Lectin galactoside-binding soluble 1(gene name synonym)|uniprotkb:Beta-galactoside-binding lectin L-14-I(gene name synonym)|uniprotkb:S-Lac lectin 1(gene name synonym)|uniprotkb:Galaptin(gene name synonym)|uniprotkb:14 kDa lectin(gene name synonym)|uniprotkb:Lactose-binding lectin 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_032521.1|ensembl:ENSMUSG00000068220(gene)|ensembl:ENSMUST00000089377(transcript)|go:"GO:0002317"(plasma cell differentiation)|go:"GO:0005534"(galactose binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0009986"(cell surface)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030395"(lactose binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0034120"(positive regulation of erythrocyte aggregation)|go:"GO:0035900"(response to isolation stress)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043236"(laminin binding)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0048678"(response to axon injury)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|interpro:IPR001079(Galectin, galactose-binding lectin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR044156|mint:P16045|rcsb pdb:4LBQ|reactome:R-MMU-381426|reactome:R-MMU-8957275	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:VMxhs6wVhql3NEex38RQeIwirZs10090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q08331	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-444808|uniprotkb:Q60964|uniprotkb:Q9JM81|ensembl:ENSMUSP00000003754	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:calb2_mouse(display_long)|uniprotkb:Calb2(gene name)|psi-mi:Calb2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_031612.1|ensembl:ENSMUSG00000003657(gene)|ensembl:ENSMUST00000003754(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005921"(gap junction)|go:"GO:0030425"(dendrite)|go:"GO:0032420"(stereocilium)|go:"GO:0043005"(neuron projection)|go:"GO:0043195"(terminal bouton)|go:"GO:0045202"(synapse)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0099509"(regulation of presynaptic cytosolic calcium ion concentration)|go:"GO:0099534"(calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR029646|go:"GO:0032437"(cuticular plate)	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:mypaOeEBzAVHi6tJRdO2BGLZzRM10090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q9Z2I9	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-773730|uniprotkb:Q3TVH1|uniprotkb:Q8BGS6|ensembl:ENSMUSP00000022706|ensembl:ENSMUSP00000123765	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:sucb1_mouse(display_long)|uniprotkb:ATP-specific succinyl-CoA synthetase subunit beta(gene name synonym)|uniprotkb:Succinyl-CoA synthetase beta-A chain(gene name synonym)|uniprotkb:Sucla2(gene name)|psi-mi:Sucla2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_035636.1|ensembl:ENSMUSG00000022110(gene)|ensembl:ENSMUST00000022706(transcript)|ensembl:ENSMUST00000160507(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004774"(succinate-CoA ligase activity)|go:"GO:0004775"("succinate-CoA ligase (ADP-forming) activity")|go:"GO:0004776"("succinate-CoA ligase (GDP-forming) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006104"(succinyl-CoA metabolic process)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0042709"(succinate-CoA ligase complex)|go:"GO:0043209"(myelin sheath)|interpro:IPR005809(Succinyl-CoA synthetase, beta subunit)|interpro:IPR005811(ATP-citrate lyase/succinyl-CoA ligase)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR013650(ATP-grasp fold, succinyl-CoA synthetase-type)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR016102(Succinyl-CoA synthetase-like)|interpro:IPR017866|interpro:IPR034723|mint:Q9Z2I9|reactome:R-MMU-71403	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:e0MauyqzSv/9q7Pt5r5PzQ+yI6c10090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q9EQ20	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634038|uniprotkb:Q3TDA2|uniprotkb:Q8CIB4|ensembl:ENSMUSP00000082288	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:mmsa_mouse(display_long)|uniprotkb:Aldh6a1(gene name)|psi-mi:Aldh6a1(display_short)|uniprotkb:Aldehyde dehydrogenase family 6 member A1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_598803.1|ensembl:ENSMUSG00000021238(gene)|ensembl:ENSMUST00000085192(transcript)|go:"GO:0004491"("methylmalonate-semialdehyde dehydrogenase (acylating) activity")|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006210"(thymine catabolic process)|go:"GO:0006573"(valine metabolic process)|go:"GO:0006574"(valine catabolic process)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0018478"("malonate-semialdehyde dehydrogenase (acetylating) activity")|go:"GO:0019484"(beta-alanine catabolic process)|go:"GO:0019859"(thymine metabolic process)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0102662"("malonate-semialdehyde dehydrogenase (acetylating, NAD+) activity")|interpro:IPR010061(Methylmalonate-semialdehyde dehydrogenase)|interpro:IPR015590(Aldehyde dehydrogenase)|interpro:IPR016160(Aldehyde dehydrogenase, conserved site)|interpro:IPR016161(Aldehyde/histidinol dehydrogenase)|interpro:IPR016162(Aldehyde dehydrogenase, N-terminal)|interpro:IPR016163(Aldehyde dehydrogenase, C-terminal)|mint:Q9EQ20|reactome:R-MMU-70895	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:pv1mVDQTYiFmfv/nAKBkdi4cSmI10090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q9CQV8	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-771608|uniprotkb:O70455|uniprotkb:Q3TY33|uniprotkb:Q3UAN6|ensembl:ENSMUSP00000018470	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:1433b_mouse(display_long)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)|uniprotkb:Ywhab(gene name)|psi-mi:Ywhab(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_061223.2|refseq:XP_006499972.1|reactome:R-MMU-111447|reactome:R-MMU-165159|reactome:R-MMU-166208|reactome:R-MMU-170968|reactome:R-MMU-2028269|reactome:R-MMU-392517|reactome:R-MMU-450385|reactome:R-MMU-450513|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-5675221|reactome:R-MMU-75035|reactome:R-MMU-9614399|ensembl:ENSMUSG00000018326(gene)|ensembl:ENSMUST00000018470(transcript)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006605"(protein targeting)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|rcsb pdb:4GNT|rcsb pdb:5F74|rcsb pdb:5WFU|rcsb pdb:5WFX	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:g94luGOxfq+Jbi0ztZ7gbAkp+2A10090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q99KI0	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-444886|uniprotkb:Q3UDK9|uniprotkb:Q3ULG9|uniprotkb:Q3UNH7|uniprotkb:Q505P4|ensembl:ENSMUSP00000023116	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:acon_mouse(display_long)|uniprotkb:Citrate hydro-lyase(gene name synonym)|uniprotkb:Aco2(gene name)|psi-mi:Aco2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_542364.1|ensembl:ENSMUSG00000022477(gene)|ensembl:ENSMUST00000023116(transcript)|go:"GO:0001889"(liver development)|go:"GO:0003994"(aconitate hydratase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006101"(citrate metabolic process)|go:"GO:0006102"(isocitrate metabolic process)|go:"GO:0035900"(response to isolation stress)|go:"GO:0043209"(myelin sheath)|go:"GO:0047780"(citrate dehydratase activity)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR000573(Aconitase A/isopropylmalate dehydratase small subunit, swivel)|interpro:IPR001030(Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha)|interpro:IPR006248(Aconitase, mitochondrial-like)|interpro:IPR015932(Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 2)|interpro:IPR018136|interpro:IPR036008|mint:Q99KI0|reactome:R-MMU-71403|interpro:IPR015928(Aconitase/3-isopropylmalate dehydratase, swivel)|interpro:IPR015931(Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomains 1 and 3)	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:0NOVcGhBwl4qmtnlhX9jcsQMdSo10090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P68510	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-444641|uniprotkb:P11576|uniprotkb:P70198|uniprotkb:Q3TGZ9|ensembl:ENSMUSP00000019109	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:1433f_mouse(display_long)|uniprotkb:Ywhah(gene name)|psi-mi:Ywhah(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_035868.1|ensembl:ENSMUSG00000018965(gene)|ensembl:ENSMUST00000019109(transcript)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006713"(glucocorticoid catabolic process)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0014704"(intercalated disc)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0086010"(membrane depolarization during action potential)|go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P68510|rcsb pdb:5YQG|go:"GO:0006886"(intracellular protein transport)|reactome:R-MMU-111447|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:Ew2uUYIXrZ8nnP52xMnGB6KOCqc10090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q9R0Y5	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-777466|uniprotkb:A2AK80|uniprotkb:Q542C5|uniprotkb:Q9R0Y4|ensembl:ENSMUSP00000108902|ensembl:ENSMUSP00000108903	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:kad1_mouse(display_long)|uniprotkb:ATP-AMP transphosphorylase 1(gene name synonym)|uniprotkb:Myokinase(gene name synonym)|uniprotkb:Ak1(gene name)|psi-mi:Ak1(display_short)|uniprotkb:"ATP:AMP phosphotransferase"(gene name synonym)|uniprotkb:Adenylate monophosphate kinase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_001185719.1|refseq:NP_001185720.1|refseq:NP_001185721.1|refseq:NP_067490.1|refseq:XP_006497687.1|ensembl:ENSMUSG00000026817(gene)|ensembl:ENSMUST00000113277(transcript)|ensembl:ENSMUST00000113278(transcript)|go:"GO:0001520"(outer dense fiber)|go:"GO:0004017"(adenylate kinase activity)|go:"GO:0004550"(nucleoside diphosphate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006165"(nucleoside diphosphate phosphorylation)|go:"GO:0006172"(ADP biosynthetic process)|go:"GO:0009142"(nucleoside triphosphate biosynthetic process)|go:"GO:0010828"(positive regulation of glucose transmembrane transport)|go:"GO:0030017"(sarcomere)|go:"GO:0036126"(sperm flagellum)|go:"GO:0043005"(neuron projection)|go:"GO:0046033"(AMP metabolic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046103"(inosine biosynthetic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR000850(Adenylate kinase)|interpro:IPR006267(Adenylate kinase, isozyme 1)|interpro:IPR027417|interpro:IPR028582|interpro:IPR033690|mint:Q9R0Y5|reactome:R-MMU-499943	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:HTydMeIFNEaVZDs7sEN7aLieuVg10090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P08030	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634025|intact:EBI-2366132|uniprotkb:Q564P4|uniprotkb:Q61319|uniprotkb:Q6PK77|uniprotkb:Q9DCY3|ensembl:ENSMUSP00000006764	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:apt_mouse(display_long)|uniprotkb:Aprt(gene name)|psi-mi:Aprt(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_033828.2|ensembl:ENSMUSG00000006589(gene)|ensembl:ENSMUST00000006764(transcript)|go:"GO:0002055"(adenine binding)|go:"GO:0003999"(adenine phosphoribosyltransferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006166"(purine ribonucleoside salvage)|go:"GO:0006168"(adenine salvage)|go:"GO:0007595"(lactation)|go:"GO:0007625"(grooming behavior)|go:"GO:0016208"(AMP binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0044209"(AMP salvage)|go:"GO:0046083"(adenine metabolic process)|interpro:IPR000836(Phosphoribosyltransferase)|interpro:IPR005764(Adenine phosphoribosyl transferase)|interpro:IPR029057|mint:P08030|reactome:R-MMU-6798695|reactome:R-MMU-74217	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:GvueBfTd2tp0OKA6mbbjZJjcBdE10090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P05064	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-494220|ensembl:ENSMUSP00000032934|ensembl:ENSMUSP00000101955	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:aldoa_mouse(display_long)|uniprotkb:Muscle-type aldolase(gene name synonym)|uniprotkb:Aldolase 1(gene name synonym)|uniprotkb:Aldoa(gene name)|psi-mi:Aldoa(display_short)|uniprotkb:Aldo1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:XP_006507273.1|refseq:XP_006507274.1|refseq:NP_001170779.1|refseq:NP_031464.1|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019242"(methylglyoxal biosynthetic process)|go:"GO:0030018"(Z disc)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0031430"(M band)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035686"(sperm fibrous sheath)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0061615"(glycolytic process through fructose-6-phosphate)|go:"GO:0061827"(sperm head)|go:"GO:0005886"(plasma membrane)|go:"GO:0070061"(fructose binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000741(Fructose-bisphosphate aldolase, class-I)|interpro:IPR013785(Aldolase-type TIM barrel)|ensembl:ENSMUSG00000030695(gene)|ensembl:ENSMUST00000032934(transcript)|ensembl:ENSMUST00000106348(transcript)|go:"GO:0000792"(heterochromatin)|go:"GO:0002020"(protease binding)|go:"GO:0004332"(fructose-bisphosphate aldolase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|mint:P05064|reactome:R-MMU-114608|reactome:R-MMU-6798695|reactome:R-MMU-70171|reactome:R-MMU-70263|interpro:IPR029768	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:m116/AX8vWkh1JCGOnEZv9ZOU9010090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P63101	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-354751|uniprotkb:P35215|uniprotkb:P70197|uniprotkb:P97286|uniprotkb:Q3TSF1|uniprotkb:Q5EBQ1|ensembl:ENSMUSP00000022894|ensembl:ENSMUSP00000105990|ensembl:ENSMUSP00000105991	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:1433z_mouse(display_long)|uniprotkb:Ywhaz(gene name)|psi-mi:Ywhaz(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)|uniprotkb:SEZ-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633914|imex:IM-9475-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_001240734.1|refseq:NP_001240735.1|refseq:NP_035870.1|refseq:XP_011243654.1|ensembl:ENSMUSG00000022285(gene)|ensembl:ENSMUST00000110361(transcript)|ensembl:ENSMUST00000110362(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0003016"(respiratory system process)|ensembl:ENSMUST00000022894(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006605"(protein targeting)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0007165"(signal transduction)|go:"GO:0008039"(synaptic target recognition)|go:"GO:0010941"(regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030324"(lung development)|go:"GO:0031252"(cell leading edge)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035148"(tube formation)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0090128"(regulation of synapse maturation)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P63101|reactome:R-MMU-111447|reactome:R-MMU-3769402|reactome:R-MMU-392517|reactome:R-MMU-430116|reactome:R-MMU-450604|reactome:R-MMU-512988|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-9013700|reactome:R-MMU-9614399|dip:DIP-31894N	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2020/10/21	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:v2N95HO8sYRWEg2gFtWiYajP1Sc10090	intact-crc:6F91E25D0AB25075|rigid:jmiCfnnRx5E79fGQMQYNprvKCnM	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q9Z2I8	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-2107688|uniprotkb:Q3T9B8|uniprotkb:Q3TJQ5|uniprotkb:Q3TK63|uniprotkb:Q66JT3|uniprotkb:Q7TMY3|uniprotkb:Q80VV1|uniprotkb:Q8K2K9|ensembl:ENSMUSP00000144827	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:sucb2_mouse(display_long)|uniprotkb:Suclg2(gene name)|psi-mi:Suclg2(display_short)|uniprotkb:GTP-specific succinyl-CoA synthetase subunit beta(gene name synonym)|uniprotkb:Succinyl-CoA synthetase beta-G chain(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_001313487.1|refseq:NP_035637.2|ensembl:ENSMUSG00000061838(gene)|ensembl:ENSMUST00000204224(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004775"("succinate-CoA ligase (ADP-forming) activity")|go:"GO:0004776"("succinate-CoA ligase (GDP-forming) activity")|go:"GO:0004777"("succinate-semialdehyde dehydrogenase (NAD+) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006104"(succinyl-CoA metabolic process)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0019003"(GDP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042709"(succinate-CoA ligase complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045244"("succinate-CoA ligase complex (GDP-forming)")|interpro:IPR005809(Succinyl-CoA synthetase, beta subunit)|interpro:IPR005811(ATP-citrate lyase/succinyl-CoA ligase)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR013650(ATP-grasp fold, succinyl-CoA synthetase-type)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR016102(Succinyl-CoA synthetase-like)|interpro:IPR017866|interpro:IPR034722|mint:Q9Z2I8|reactome:R-MMU-71403	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:V1vkzx6MwooUIe9d/A66CRAoygA10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P62259	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-356480|uniprotkb:P29360|uniprotkb:P42655|uniprotkb:Q63631|ensembl:ENSMUSP00000070993	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:1433e_mouse(display_long)|uniprotkb:Ywhae(gene name)|psi-mi:Ywhae(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	ensembl:ENSMUSG00000020849(gene)|ensembl:ENSMUST00000067664(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001764"(neuron migration)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0006605"(protein targeting)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030424"(axon)|refseq:NP_033562.3|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0090724"(central region of growth cone)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1902309"(negative regulation of peptidyl-serine dephosphorylation)|go:"GO:1905913"(negative regulation of calcium ion export across plasma membrane)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P62259|reactome:R-MMU-111447|reactome:R-MMU-2028269|reactome:R-MMU-205025|reactome:R-MMU-2565942|reactome:R-MMU-3371453|reactome:R-MMU-3371511|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-8854518|reactome:R-MMU-8876198	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:mnuAjdnQZbMFojll2PnV3xFklXQ10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q62465	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-911848|uniprotkb:Q8R3G0|uniprotkb:Q8R3T8|ensembl:ENSMUSP00000048350	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:vat1_mouse(display_long)|uniprotkb:Vat1(gene name)|psi-mi:Vat1(display_short)|uniprotkb:Vat-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	ensembl:ENSMUSG00000034993(gene)|ensembl:ENSMUST00000040430(transcript)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016491"(oxidoreductase activity)|interpro:IPR002364(Quinone oxidoreductase/zeta-crystallin, conserved site)|interpro:IPR011032(GroES-like)|interpro:IPR013154(Alcohol dehydrogenase GroES-like)|interpro:IPR020843|interpro:IPR036291|mint:Q62465|reactome:R-MMU-6798695|refseq:NP_036167.1	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:z+QTKmncP2v/Qu1qdcPUTPMozVQ10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q9D051	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-773622|uniprotkb:Q3TL86|uniprotkb:Q505N8|uniprotkb:Q99LW9|ensembl:ENSMUSP00000022268	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:odpb_mouse(display_long)|uniprotkb:Pdhb(gene name)|psi-mi:Pdhb(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_077183.1|ensembl:ENSMUSG00000021748(gene)|ensembl:ENSMUST00000022268(transcript)|go:"GO:0004739"("pyruvate dehydrogenase (acetyl-transferring) activity")|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005967"(mitochondrial pyruvate dehydrogenase complex)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006086"(acetyl-CoA biosynthetic process from pyruvate)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0034604"("pyruvate dehydrogenase (NAD+) activity")|go:"GO:0045254"(pyruvate dehydrogenase complex)|go:"GO:0061732"(mitochondrial acetyl-CoA biosynthetic process from pyruvate)|interpro:IPR005475(Transketolase, central region)|interpro:IPR009014(Transketolase, C-terminal/Pyruvate-ferredoxin oxidoreductase, domain II)|interpro:IPR027110|interpro:IPR029061|interpro:IPR033248|mint:Q9D051|reactome:R-MMU-204174|reactome:R-MMU-389661|reactome:R-MMU-5362517|reactome:R-MMU-70268	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:FPts4odLhVgLVf3gEYdc9N5Wuak10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P17182	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-299507|ensembl:ENSMUSP00000075513|ensembl:ENSMUSP00000079727|ensembl:ENSMUSP00000157807|uniprotkb:Q99KT7|uniprotkb:Q9DCY7	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:enoa_mouse(display_long)|uniprotkb:Eno1(gene name)|psi-mi:Eno1(display_short)|uniprotkb:Eno-1(gene name synonym)|uniprotkb:2-phospho-D-glycerate hydro-lyase(gene name synonym)|uniprotkb:Non-neural enolase(gene name synonym)|uniprotkb:Enolase 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	ensembl:ENSMUSG00000059040(gene)|ensembl:ENSMUSG00000063524(gene)|ensembl:ENSMUST00000076155(transcript)|ensembl:ENSMUST00000080926(transcript)|ensembl:ENSMUST00000235307(transcript)|go:"GO:0000015"(phosphopyruvate hydratase complex)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003723"(RNA binding)|go:"GO:0004634"(phosphopyruvate hydratase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006096"(glycolytic process)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030426"(growth cone)|go:"GO:0032889"(regulation of vacuole fusion, non-autophagic)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043209"(myelin sheath)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0051020"(GTPase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0051099"(positive regulation of binding)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0099738"(cell cortex region)|interpro:IPR000941(Enolase)|interpro:IPR020809|interpro:IPR020810|interpro:IPR020811|interpro:IPR029017|interpro:IPR036849|mint:P17182|reactome:R-MMU-70171|reactome:R-MMU-70263|refseq:NP_001020559.1|refseq:NP_075608.2|refseq:XP_006538588.2	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:YFpn/7GDB6vXgCYLSxvNns7FlT410090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q61838	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634799|uniprotkb:Q60628|uniprotkb:Q6PEM2|uniprotkb:E9QPW0|ensembl:ENSMUSP00000107760	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:pzp_mouse(display_long)|uniprotkb:Pzp(gene name)|psi-mi:Pzp(display_short)|uniprotkb:A2m(gene name synonym)|uniprotkb:Alpha-2-macroglobulin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	ensembl:ENSMUSG00000030359(gene)|ensembl:ENSMUST00000112132(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007566"(embryo implantation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048403"(brain-derived neurotrophic factor binding)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR019742|interpro:IPR036595|interpro:IPR040839|interpro:IPR041555|interpro:IPR041813|mint:Q61838	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:13HlU9eYafEKSQ8XDvNJwdKQduU10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P97807	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634334|uniprotkb:Q99JL0|uniprotkb:Q9DCX0|intact:EBI-2257633|uniprotkb:Q3UIA9|ensembl:ENSMUSP00000027810	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:fumh_mouse(display_long)|uniprotkb:Fh(gene name)|psi-mi:Fh(display_short)|uniprotkb:Fh1(gene name synonym)|uniprotkb:EF-3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_034339.2|ensembl:ENSMUSG00000026526(gene)|ensembl:ENSMUST00000027810(transcript)|go:"GO:0000050"(urea cycle)|go:"GO:0000415"(negative regulation of histone H3-K36 methylation)|go:"GO:0000821"(regulation of arginine metabolic process)|go:"GO:0004333"(fumarate hydratase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006106"(fumarate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0045239"(tricarboxylic acid cycle enzyme complex)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR000362(Fumarate lyase)|interpro:IPR005677(Fumarate hydratase, class II)|interpro:IPR008948(L-Aspartase-like)|interpro:IPR018951|interpro:IPR020557|interpro:IPR022761|interpro:IPR024083|mint:P97807|reactome:R-MMU-71403	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:iF/OldWMCxdHfdZo+JtXmx8PbFQ10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q9CWS0	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634249|uniprotkb:Q3UF65|ensembl:ENSMUSP00000029845	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:ddah1_mouse(display_long)|uniprotkb:Ddah1(gene name)|psi-mi:Ddah1(display_short)|uniprotkb:DDAHI(gene name synonym)|uniprotkb:Dimethylargininase-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_081269.1|ensembl:ENSMUSG00000028194(gene)|ensembl:ENSMUST00000029845(transcript)|go:"GO:0000052"(citrulline metabolic process)|go:"GO:0003073"(regulation of systemic arterial blood pressure)|go:"GO:0005739"(mitochondrion)|go:"GO:0006525"(arginine metabolic process)|go:"GO:0006527"(arginine catabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016403"(dimethylargininase activity)|go:"GO:0016597"(amino acid binding)|go:"GO:0017014"(protein nitrosylation)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:1900038"(negative regulation of cellular response to hypoxia)|interpro:IPR033197|interpro:IPR033199|mint:Q9CWS0|reactome:R-MMU-203615	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:u86ORy2QbWs+lD01MN69ejGnDgE10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:O55103	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634712|uniprotkb:O55104	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:prax_mouse(display_long)|uniprotkb:Prx(gene name)|psi-mi:Prx(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	mint:O55103|refseq:NP_062285.1|refseq:NP_932165.2|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030054"(cell junction)|go:"GO:0032287"(peripheral nervous system myelin maintenance)|go:"GO:0032290"(peripheral nervous system myelin formation)|go:"GO:0043209"(myelin sheath)|go:"GO:0043484"(regulation of RNA splicing)	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:UbopA9GWlR9IztLq81yYM60Zt1M10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q922A2	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634086	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:q922a2_mouse(display_long)|uniprotkb:Anxa7(gene name)|psi-mi:Anxa7(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	interpro:IPR001464(Annexin)|interpro:IPR018502|interpro:IPR018252|interpro:IPR037104|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:cQdRjAxcZiRIQlu2Rlq18CBaFvM10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P17918	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1173716|ensembl:ENSMUSP00000028817	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:pcna_mouse(display_long)|uniprotkb:Pcna(gene name)|psi-mi:Pcna(display_short)|uniprotkb:Cyclin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005813"(centrosome)|go:"GO:0006272"(leading strand elongation)|go:"GO:0006287"(base-excision repair, gap-filling)|go:"GO:0006298"(mismatch repair)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0000701"(purine-specific mismatch base pair DNA N-glycosylase activity)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031297"(replication fork processing)|go:"GO:0032077"(positive regulation of deoxyribonuclease activity)|go:"GO:0032139"(dinucleotide insertion or deletion binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032405"(MutLalpha complex binding)|go:"GO:0033993"(response to lipid)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042802"(identical protein binding)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0043626"(PCNA complex)|go:"GO:0044849"(estrous cycle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070557"(PCNA-p21 complex)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0097421"(liver regeneration)|go:"GO:1900264"(positive regulation of DNA-directed DNA polymerase activity)|go:"GO:1902065"(response to L-glutamate)|go:"GO:1902990"(mitotic telomere maintenance via semi-conservative replication)|interpro:IPR000730(Proliferating cell nuclear antigen, PCNA)|interpro:IPR022648|interpro:IPR022649|interpro:IPR022659|mint:P17918|reactome:R-MMU-110312|go:"GO:0035035"(histone acetyltransferase binding)|reactome:R-MMU-110314|reactome:R-MMU-110320|reactome:R-MMU-174411|reactome:R-MMU-174414|reactome:R-MMU-174417|reactome:R-MMU-174437|reactome:R-MMU-4615885|reactome:R-MMU-5358565|reactome:R-MMU-5651801|reactome:R-MMU-5655862|reactome:R-MMU-5656121|reactome:R-MMU-5656169|reactome:R-MMU-5685942|reactome:R-MMU-5696397|reactome:R-MMU-5696400|reactome:R-MMU-6782135|reactome:R-MMU-6782210|reactome:R-MMU-6804114|reactome:R-MMU-69091|ensembl:ENSMUSG00000027342(gene)|ensembl:ENSMUST00000028817(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|refseq:NP_035175.1|reactome:R-MMU-69166|reactome:R-MMU-69183|reactome:R-MMU-8866654|dip:DIP-39409N	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:AREQR8Nveu4uamAlZuOEwlnDDec10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P29699	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-738276|uniprotkb:O35634|ensembl:ENSMUSP00000023583	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:fetua_mouse(display_long)|uniprotkb:Ahsg(gene name)|psi-mi:Ahsg(display_short)|uniprotkb:Fetua(gene name synonym)|uniprotkb:Fetuin-A(gene name synonym)|uniprotkb:Countertrypin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_038493.1|ensembl:ENSMUSG00000022868(gene)|ensembl:ENSMUST00000023583(transcript)|go:"GO:0001503"(ossification)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006953"(acute-phase response)|go:"GO:0008584"(male gonad development)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0030294"(receptor signaling protein tyrosine kinase inhibitor activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR000010(Proteinase inhibitor I25, cystatin)|interpro:IPR001363(Proteinase inhibitor I25C, fetuin, conserved site)|interpro:IPR025760|mint:P29699|reactome:R-MMU-114608|reactome:R-MMU-381426|reactome:R-MMU-6798695|reactome:R-MMU-8957275	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:t73hmO6nmlFcT2TpnfdmQbYVRXA10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P27573	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634589|uniprotkb:Q542C9	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:myp0_mouse(display_long)|uniprotkb:Mpz(gene name)|psi-mi:Mpz(display_short)|uniprotkb:P0(gene name synonym)|uniprotkb:Myelin protein zero(gene name synonym)|uniprotkb:Myelin peripheral protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_001302428.1|refseq:NP_001302429.1|refseq:NP_032649.2|dip:DIP-51664N|go:"GO:0005764"(lysosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0042552"(myelination)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043209"(myelin sheath)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098743"(cell aggregation)|interpro:IPR000920(Myelin P0 protein)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR019566|interpro:IPR019738|interpro:IPR029869|interpro:IPR036179	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:n7Go3hYQ/2jR857QJQnI5GWwqrc10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q3KQQ4	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1635042	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:q3kqq4_mouse(display_long)|uniprotkb:Serpina1b(gene name)|psi-mi:Serpina1b(display_short)|uniprotkb:Serpina1a(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR023795|interpro:IPR023796|interpro:IPR042178|interpro:IPR042185|interpro:IPR036186|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:RjTHwhah+LcufaimjiDfoW5HxNc10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P17742	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1206043|uniprotkb:Q9CWJ5|uniprotkb:Q9R137|ensembl:ENSMUSP00000117987	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:ppia_mouse(display_long)|uniprotkb:Ppia(gene name)|psi-mi:Ppia(display_short)|uniprotkb:Cyclophilin A(gene name synonym)|uniprotkb:Cyclosporin A-binding protein(gene name synonym)|uniprotkb:SP18(gene name synonym)|uniprotkb:Rotamase A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_032933.1|reactome:R-MMU-210991|reactome:R-MMU-6798695|rcsb pdb:6FK1|ensembl:ENSMUSG00000071866(gene)|ensembl:ENSMUST00000132846(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006915"(apoptotic process)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032873"(negative regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060352"(cell adhesion molecule production)|go:"GO:0061944"(negative regulation of protein K48-linked ubiquitination)|go:"GO:0070527"(platelet aggregation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903901"(negative regulation of viral life cycle)|go:"GO:1904399"(heparan sulfate binding)|go:"GO:2001233"(regulation of apoptotic signaling pathway)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR020892|interpro:IPR024936|interpro:IPR029000|mint:P17742	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:VwIoW2yfdaAEwZj6MfekFYqkZjw10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q93092	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1635144|uniprotkb:P70358|uniprotkb:P70703|uniprotkb:Q52KM4|ensembl:ENSMUSP00000026576	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:taldo_mouse(display_long)|uniprotkb:Taldo1(gene name)|psi-mi:Taldo1(display_short)|uniprotkb:Tal(gene name synonym)|uniprotkb:Taldo(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_035658.1|ensembl:ENSMUSG00000025503(gene)|ensembl:ENSMUST00000026576(transcript)|go:"GO:0004801"(transaldolase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006098"(pentose-phosphate shunt)|go:"GO:0009052"(pentose-phosphate shunt, non-oxidative branch)|go:"GO:0019682"(glyceraldehyde-3-phosphate metabolic process)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048029"(monosaccharide binding)|interpro:IPR001585(Transaldolase)|interpro:IPR004730(Transaldolase AB)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR018225|mint:Q93092|rcsb pdb:2CWN|rcsb pdb:2E1D|reactome:R-MMU-163754|reactome:R-MMU-71336	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:Zrei1D2j/wp5pDx3MczTfgQ6mDU10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q8BFZ9	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1635049|uniprotkb:Q8BML8|ensembl:ENSMUSP00000033873	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:erln2_mouse(display_long)|uniprotkb:Erlin2(gene name)|psi-mi:Erlin2(display_short)|uniprotkb:Spfh2(gene name synonym)|uniprotkb:Endoplasmic reticulum lipid raft-associated protein 2(gene name synonym)|uniprotkb:Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_705820.1|refseq:XP_006509179.1|refseq:XP_006509180.1|ensembl:ENSMUSG00000031483(gene)|ensembl:ENSMUST00000033873(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045121"(membrane raft)|go:"GO:0045541"(negative regulation of cholesterol biosynthetic process)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|interpro:IPR001107(Band 7 protein)|interpro:IPR033294|interpro:IPR036013|mint:Q8BFZ9|reactome:R-MMU-382556	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:/OxFugzl4zprvnZbqOGcXmUe3ao10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q03265	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-299884|ensembl:ENSMUSP00000026495|uniprotkb:Q3TFN0|uniprotkb:Q3THN8|uniprotkb:Q3TPR0|uniprotkb:Q3TPV3|uniprotkb:Q3TZU3|uniprotkb:Q3UIR7|uniprotkb:Q543Y6	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:atpa_mouse(display_long)|uniprotkb:Atp5f1a(gene name)|psi-mi:Atp5f1a(display_short)|uniprotkb:ATP synthase F1 subunit alpha(gene name synonym)|uniprotkb:Atp5a1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|ensembl:ENSMUSG00000025428(gene)|ensembl:ENSMUST00000026495(transcript)|go:"GO:0000275"("mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)")|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005754"(mitochondrial proton-transporting ATP synthase, catalytic core)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0009986"(cell surface)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016020"(membrane)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0043209"(myelin sheath)|go:"GO:0043531"(ADP binding)|go:"GO:0043532"(angiostatin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045259"(proton-transporting ATP synthase complex)|go:"GO:0045261"("proton-transporting ATP synthase complex, catalytic core F(1)")|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|interpro:IPR000194(ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)|interpro:IPR000793(ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal)|interpro:IPR004100(ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal)|interpro:IPR005294(ATPase, F1 complex, alpha subunit)|interpro:IPR020003|interpro:IPR023366|interpro:IPR027417|interpro:IPR033732|interpro:IPR036121|interpro:IPR038376|mint:Q03265|reactome:R-MMU-163210|reactome:R-MMU-8949613|refseq:NP_031531.1	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:sBPTQwqC0dJTjZlZMKRzTSu6gHg10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:O88952	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-821316|ensembl:ENSMUSP00000028583	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:lin7c_mouse(display_long)|uniprotkb:Mammalian lin-seven protein 3(gene name synonym)|uniprotkb:Vertebrate lin-7 homolog 3(gene name synonym)|uniprotkb:Veli3(gene name synonym)|uniprotkb:Lin7c(gene name)|psi-mi:Lin7c(display_short)|uniprotkb:Mals3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_035829.1|ensembl:ENSMUSG00000027162(gene)|ensembl:ENSMUST00000028583(transcript)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006887"(exocytosis)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0045202"(synapse)|go:"GO:0097016"(L27 domain binding)|go:"GO:0097025"(MPP7-DLG1-LIN7 complex)|go:"GO:0098793"(presynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903361"(protein localization to basolateral plasma membrane)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR014775(L27, C-terminal)|interpro:IPR017365(Lin-7 homologue)|interpro:IPR036034|interpro:IPR036892|reactome:R-MMU-212676	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:F2rasaJ64Olc9qScN79LJRqsUEE10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q00623	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634106|uniprotkb:Q8BPD5|uniprotkb:O08855|uniprotkb:O09042|ensembl:ENSMUSP00000034588	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:apoa1_mouse(display_long)|uniprotkb:Apoa1(gene name)|psi-mi:Apoa1(display_short)|uniprotkb:Apolipoprotein A1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_033822.2|ensembl:ENSMUSG00000032083(gene)|ensembl:ENSMUST00000034588(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006656"(phosphatidylcholine biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008211"(glucocorticoid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0009986"(cell surface)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010898"(positive regulation of triglyceride catabolic process)|go:"GO:0010903"(negative regulation of very-low-density lipoprotein particle remodeling)|go:"GO:0015485"(cholesterol binding)|go:"GO:0015914"(phospholipid transport)|go:"GO:0018158"(protein oxidation)|go:"GO:0018206"(peptidyl-methionine modification)|go:"GO:0019899"(enzyme binding)|go:"GO:0019915"(lipid storage)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030300"(regulation of intestinal cholesterol absorption)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030325"(adrenal gland development)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034190"(apolipoprotein receptor binding)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034363"(intermediate-density lipoprotein particle)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0034365"(discoidal high-density lipoprotein particle)|go:"GO:0034366"(spherical high-density lipoprotein particle)|go:"GO:0034372"(very-low-density lipoprotein particle remodeling)|go:"GO:0034375"(high-density lipoprotein particle remodeling)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042158"(lipoprotein biosynthetic process)|go:"GO:0042627"(chylomicron)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0045723"(positive regulation of fatty acid biosynthetic process)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050821"(protein stabilization)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0051180"(vitamin transport)|go:"GO:0051345"(positive regulation of hydrolase activity)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0055102"(lipase inhibitor activity)|go:"GO:0060192"(negative regulation of lipase activity)|go:"GO:0060228"(phosphatidylcholine-sterol O-acyltransferase activator activity)|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070508"(cholesterol import)|go:"GO:0070653"(high-density lipoprotein particle receptor binding)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902995"(positive regulation of phospholipid efflux)|interpro:IPR000074(Apolipoprotein A1/A4/E)|mint:Q00623|rcsb pdb:2LEM|reactome:R-MMU-114608|reactome:R-MMU-1369062|reactome:R-MMU-2168880|reactome:R-MMU-3000471|reactome:R-MMU-3000480|reactome:R-MMU-381426|reactome:R-MMU-8957275|reactome:R-MMU-8963888|reactome:R-MMU-8963896|reactome:R-MMU-8963901|reactome:R-MMU-8964011|reactome:R-MMU-8964058|reactome:R-MMU-9707616|reactome:R-MMU-975634	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:RFvdsVcof99jM6K/bEi1N1Vn9hE10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P62835	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634972|uniprotkb:P10113|ensembl:ENSMUSP00000088174	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:rap1a_mouse(display_long)|uniprotkb:Rap1a(gene name)|psi-mi:Rap1a(display_short)|uniprotkb:Krev-1(gene name synonym)|uniprotkb:Ras-related protein Krev-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_663516.1|refseq:XP_006500970.1|ensembl:ENSMUSG00000068798(gene)|ensembl:ENSMUST00000090678(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0019003"(GDP binding)|go:"GO:0030054"(cell junction)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0032486"(Rap protein signal transduction)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0035690"|go:"GO:0038180"(nerve growth factor signaling pathway)|go:"GO:0043005"(neuron projection)|go:"GO:0043209"(myelin sheath)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097327"(response to antineoplastic agent)|go:"GO:0097421"(liver regeneration)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901888"(regulation of cell junction assembly)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR038851|mint:P62835|reactome:R-MMU-170968|reactome:R-MMU-170984|reactome:R-MMU-354192|reactome:R-MMU-354194|reactome:R-MMU-372708|reactome:R-MMU-381676|reactome:R-MMU-392517|reactome:R-MMU-5674135|reactome:R-MMU-6798695|reactome:R-MMU-8875555	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:QtjMjJiMQF0CbTD40IZgca4XfIU10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q9CQA3	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-432494|uniprotkb:Q3TF82|uniprotkb:Q9DC91|ensembl:ENSMUSP00000010007	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:sdhb_mouse(display_long)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym)|uniprotkb:Sdhb(gene name)|psi-mi:Sdhb(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_075863.2|ensembl:ENSMUSG00000009863(gene)|ensembl:ENSMUST00000010007(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0045273"(respiratory chain complex II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|mint:Q9CQA3|reactome:R-MMU-71403	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:867rMxM9LEdIwyu93mUmDNc1S0o10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P17183	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634308|ensembl:ENSMUSP00000004378	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:enog_mouse(display_long)|uniprotkb:Eno2(gene name)|psi-mi:Eno2(display_short)|uniprotkb:Eno-2(gene name synonym)|uniprotkb:2-phospho-D-glycerate hydro-lyase(gene name synonym)|uniprotkb:Neural enolase(gene name synonym)|uniprotkb:Neuron-specific enolase(gene name synonym)|uniprotkb:Enolase 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_038537.1|refseq:NP_001289571.1|refseq:XP_006505566.1|refseq:XP_006505567.1|ensembl:ENSMUSG00000004267(gene)|ensembl:ENSMUST00000004378(transcript)|go:"GO:0000015"(phosphopyruvate hydratase complex)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0004634"(phosphopyruvate hydratase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006096"(glycolytic process)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030426"(growth cone)|go:"GO:0032889"(regulation of vacuole fusion, non-autophagic)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043209"(myelin sheath)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0097060"(synaptic membrane)|go:"GO:0099738"(cell cortex region)|interpro:IPR000941(Enolase)|interpro:IPR020809|interpro:IPR020810|interpro:IPR020811|interpro:IPR029017|interpro:IPR036849|mint:P17183|reactome:R-MMU-70171|reactome:R-MMU-70263	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:bEXS2/h1idLiCLtUPFHMwtCMV5I10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P08551	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-445199|uniprotkb:Q8K0Z0|ensembl:ENSMUSP00000022639	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:nfl_mouse(display_long)|uniprotkb:Neurofilament triplet L protein(gene name synonym)|uniprotkb:68 kDa neurofilament protein(gene name synonym)|uniprotkb:Nefl(gene name)|psi-mi:Nefl(display_short)|uniprotkb:Nfl(gene name synonym)|uniprotkb:Nf68(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_035040.1|ensembl:ENSMUSG00000022055(gene)|ensembl:ENSMUST00000022639(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0005882"(intermediate filament)|go:"GO:0005883"(neurofilament)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0009636"(response to toxic substance)|go:"GO:0014012"(peripheral nervous system axon regeneration)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0099160"(postsynaptic intermediate filament cytoskeleton)|go:"GO:0099182"(presynaptic intermediate filament cytoskeleton)|go:"GO:0099184"(structural constituent of postsynaptic intermediate filament cytoskeleton)|go:"GO:1903935"(response to sodium arsenite)|go:"GO:1903937"(response to acrylamide)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR027692|interpro:IPR039008|mint:P08551|reactome:R-MMU-438066|reactome:R-MMU-5673001|go:"GO:0098981"(cholinergic synapse)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031133"(regulation of axon diameter)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0033693"(neurofilament bundle assembly)|go:"GO:0040011"(locomotion)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043209"(myelin sheath)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045105"(intermediate filament polymerization or depolymerization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045110"(intermediate filament bundle assembly)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051258"(protein polymerization)|go:"GO:0051412"(response to corticosterone)|go:"GO:0060052"(neurofilament cytoskeleton organization)|go:"GO:0060074"(synapse maturation)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|dip:DIP-31944N	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:E8KK2ppZXyLXIlFZp/pjXv7GBEU10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q8K0E8	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634324|uniprotkb:Q91ZP1|ensembl:ENSMUSP00000039472	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:fibb_mouse(display_long)|uniprotkb:Fgb(gene name)|psi-mi:Fgb(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_862897.1|ensembl:ENSMUSG00000033831(gene)|ensembl:ENSMUST00000048246(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005938"(cell cortex)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031639"(plasminogen activation)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034622"|go:"GO:0042730"(fibrinolysis)|go:"GO:0043152"(induction of bacterial agglutination)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051258"(protein polymerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0072562"(blood microparticle)|go:"GO:0090277"(positive regulation of peptide hormone secretion)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR012290(Fibrinogen, alpha/beta/gamma chain, coiled coil)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR036056|interpro:IPR037580|mint:Q8K0E8|reactome:R-MMU-114608|reactome:R-MMU-140875|reactome:R-MMU-216083|reactome:R-MMU-354192|reactome:R-MMU-354194|reactome:R-MMU-372708|reactome:R-MMU-5674135|reactome:R-MMU-5686938	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:bEenetOknasilOE63oJ+BAi+PlI10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P46660	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-400482|uniprotkb:Q61958|uniprotkb:Q8VCW5|ensembl:ENSMUSP00000041347	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:ainx_mouse(display_long)|uniprotkb:Ina(gene name)|psi-mi:Ina(display_short)|uniprotkb:66 kDa neurofilament protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_666212.3|ensembl:ENSMUSG00000034336(gene)|ensembl:ENSMUST00000037636(transcript)|go:"GO:0005883"(neurofilament)|go:"GO:0007399"(nervous system development)|go:"GO:0030154"(cell differentiation)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043209"(myelin sheath)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0060052"(neurofilament cytoskeleton organization)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099160"(postsynaptic intermediate filament cytoskeleton)|go:"GO:0099184"(structural constituent of postsynaptic intermediate filament cytoskeleton)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR027703|interpro:IPR039008|mint:P46660	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:amjP0AajB8s2oXmV96wzyfz6evE10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P68366	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-351772|uniprotkb:A8MUB1|uniprotkb:P05215|ensembl:ENSP00000248437|uniprotkb:B3KNQ6|intact:EBI-11134566	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:tba4a_human(display_long)|uniprotkb:TUBA4A(gene name)|psi-mi:TUBA4A(display_short)|uniprotkb:Tubulin alpha-1 chain(gene name synonym)|uniprotkb:Alpha-tubulin 1(gene name synonym)|uniprotkb:Testis-specific alpha-tubulin(gene name synonym)|uniprotkb:Tubulin H2-alpha(gene name synonym)|uniprotkb:TUBA1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_005991.1|ensembl:ENSG00000127824(gene)|ensembl:ENST00000248437(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019901"(protein kinase binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000217(Tubulin)|interpro:IPR002452(Alpha tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:P68366|reactome:R-HSA-114608|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620912|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189|refseq:NP_001265481.1	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:6Oj9O8u7E6cLUJ1eT6y5slbk7uQ9606	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q9EQX4	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634547|uniprotkb:Q8C150|ensembl:ENSMUSP00000001920	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:aif1l_mouse(display_long)|uniprotkb:Iba2(gene name synonym)|uniprotkb:Ionized calcium-binding adapter molecule 2(gene name synonym)|uniprotkb:Aif1l(gene name)|psi-mi:Aif1l(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_660126.1|ensembl:ENSMUSG00000001864(gene)|ensembl:ENSMUST00000001920(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005884"(actin filament)|go:"GO:0005925"(focal adhesion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0097178"(ruffle assembly)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR028453|interpro:IPR042433	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:/ALMwhv/lHihdH7qdfjLIyKB1Ek10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P62748	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634477|uniprotkb:P35333|ensembl:ENSMUSP00000071756	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:hpcl1_mouse(display_long)|uniprotkb:Hpcal1(gene name)|psi-mi:Hpcal1(display_short)|uniprotkb:Visinin-like protein 3(gene name synonym)|uniprotkb:Neural visinin-like protein 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_057886.1|refseq:XP_006515219.1|refseq:XP_006515220.1|ensembl:ENSMUSG00000071379(gene)|ensembl:ENSMUST00000071858(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0016020"(membrane)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR028846	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:ZLX+Km49SxhIW99F/wJ2adBYZ2Q10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P63028	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1635228|uniprotkb:P14701|uniprotkb:Q3TMT0|uniprotkb:Q3TWS8|uniprotkb:Q3TWX0|uniprotkb:Q3UAG7|uniprotkb:Q569M9|ensembl:ENSMUSP00000106519	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:tctp_mouse(display_long)|uniprotkb:Tpt1(gene name)|psi-mi:Tpt1(display_short)|uniprotkb:Trt(gene name synonym)|uniprotkb:p23(gene name synonym)|uniprotkb:21 kDa polypeptide(gene name synonym)|uniprotkb:p21(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_033455.1|ensembl:ENSMUSG00000060126(gene)|ensembl:ENSMUST00000110894(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0005829"(cytosol)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009615"(response to virus)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:2000384"(negative regulation of ectoderm development)|interpro:IPR011057(Mss4-like)|interpro:IPR011323(Mss4/translationally controlled tumour-associated TCTP)|interpro:IPR018103|interpro:IPR018105|interpro:IPR034737|mint:P63028|rcsb pdb:5O9K	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:4STBIjAMhg84kMGx/MP1PUh6g4g10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q62433	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634677|uniprotkb:P97862|ensembl:ENSMUSP00000005256	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:ndrg1_mouse(display_long)|uniprotkb:Ndrg1(gene name)|psi-mi:Ndrg1(display_short)|uniprotkb:Ndr1(gene name synonym)|uniprotkb:Ndrl(gene name synonym)|uniprotkb:Tdd5(gene name synonym)|uniprotkb:N-myc downstream-regulated gene 1 protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_032707.2|ensembl:ENSMUSG00000005125(gene)|ensembl:ENSMUST00000005256(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007165"(signal transduction)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032287"(peripheral nervous system myelin maintenance)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0045296"(cadherin binding)|go:"GO:0045576"(mast cell activation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099173"(postsynapse organization)|interpro:IPR004142(Ndr)|interpro:IPR029058|interpro:IPR030693|mint:Q62433	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:xHk93Xyd6J7xICgNcYrInWltnlE10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P80314	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-772351|uniprotkb:Q9R1U0|ensembl:ENSMUSP00000036288	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:tcpb_mouse(display_long)|uniprotkb:CCT-beta(gene name synonym)|uniprotkb:Cct2(gene name)|psi-mi:Cct2(display_short)|uniprotkb:Cctb(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_031662.2|refseq:XP_006513224.1|dip:DIP-32343N|ensembl:ENSMUSG00000034024(gene)|ensembl:ENSMUST00000047672(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0043209"(myelin sheath)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051086"(chaperone mediated protein folding independent of cofactor)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012716(T-complex protein 1, beta subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P80314|reactome:R-MMU-390471|reactome:R-MMU-5620922|reactome:R-MMU-6798695|reactome:R-MMU-6814122|reactome:R-MMU-9013418|reactome:R-MMU-9013422	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:1CGHdF6g9ZqNbyRmQ5l3eUgD5Ow10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P63038	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-299343|ensembl:ENSMUSP00000027123|uniprotkb:P19226|uniprotkb:P19227|uniprotkb:P97602|uniprotkb:Q3KQP2|uniprotkb:Q3UIP0|uniprotkb:Q8C2C7|uniprotkb:Q8VEF4	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:ch60_mouse(display_long)|uniprotkb:Hspd1(gene name)|psi-mi:Hspd1(display_short)|uniprotkb:Hsp60(gene name synonym)|uniprotkb:Heat shock protein 60(gene name synonym)|uniprotkb:60 kDa chaperonin(gene name synonym)|uniprotkb:Chaperonin 60(gene name synonym)|uniprotkb:Mitochondrial matrix protein P1(gene name synonym)|uniprotkb:HSP-65(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	ensembl:ENSMUSG00000025980(gene)|ensembl:ENSMUST00000027123(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002039"(p53 binding)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0002842"(positive regulation of T cell mediated immune response to tumor cell)|go:"GO:0002931"(response to ischemia)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005769"(early endosome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006457"(protein folding)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009409"(response to cold)|go:"GO:0009986"(cell surface)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016853"(isomerase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030135"(coated vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033198"(response to ATP)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034514"(mitochondrial unfolded protein response)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042026"(protein refolding)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042588"(zymogen granule)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0045121"(membrane raft)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0048291"(isotype switching to IgG isotypes)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051087"(chaperone binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071866"(negative regulation of apoptotic process in bone marrow cell)|go:"GO:0097225"(sperm midpiece)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0140030"(modification-dependent protein binding)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|interpro:IPR001844(Chaperonin Cpn60)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR018370|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P63038|reactome:R-MMU-1268020|refseq:XP_006495769.1|refseq:NP_034607.3|dip:DIP-31396N	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:WD1fQLh4I0ovpakE8KtM1R0XpL410090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P48678-2	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-303677|ensembl:ENSMUSP00000113093|uniprotkb:P11516-1	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:p48678-2(display_long)|uniprotkb:Lmna(gene name)|psi-mi:Lmna(display_short)|uniprotkb:Lmn1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	ensembl:ENSMUSG00000028063(gene)|ensembl:ENSMUST00000120377(transcript)|intact:EBI-299212(lamc_mouse)	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	isoform-comment:Contains a phosphoserine at position 392. Contains a phosphoserine at position 407. Contains a phosphoserine at position 409. Contains a phosphoserine at position 572.	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:7vdGo07vcDnXqfx/RAMWNGl8/Hg10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q8K183	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634920|uniprotkb:Q3TM83|uniprotkb:Q8BJQ5|ensembl:ENSMUSP00000038540	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:pdxk_mouse(display_long)|uniprotkb:Pdxk(gene name)|psi-mi:Pdxk(display_short)|uniprotkb:Pkh(gene name synonym)|uniprotkb:Pyridoxine kinase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_742146.1|ensembl:ENSMUSG00000032788(gene)|ensembl:ENSMUST00000041616(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008478"(pyridoxal kinase activity)|go:"GO:0009443"(pyridoxal 5'-phosphate salvage)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031402"(sodium ion binding)|go:"GO:0031403"(lithium ion binding)|go:"GO:0036094"(small molecule binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042823"(pyridoxal phosphate biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0070280"(pyridoxal binding)|interpro:IPR004625("Pyridoxal phosphate (active vitamin B6) biosynthesis, pyridoxal kinase")|interpro:IPR013749(Phosphomethylpyrimidine kinase type-1)|interpro:IPR029056|mint:Q8K183|rcsb pdb:6YK0|rcsb pdb:6YK1|reactome:R-MMU-6798695|reactome:R-MMU-964975	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:z+mCly2nHtdLZ6dlMOMpWgUi+1s10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P38647	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-772469|uniprotkb:Q9CQ05|intact:EBI-4282065|uniprotkb:Q3TW93|uniprotkb:Q3UVN1|uniprotkb:Q3V015|intact:EBI-1635058|uniprotkb:Q7TSZ0|ensembl:ENSMUSP00000025217	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:grp75_mouse(display_long)|uniprotkb:75 kDa glucose-regulated protein(gene name synonym)|uniprotkb:p66 MOT(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 9(gene name synonym)|uniprotkb:Peptide-binding protein 74(gene name synonym)|uniprotkb:Mortalin(gene name synonym)|uniprotkb:Hspa9(gene name)|psi-mi:Hspa9(display_short)|uniprotkb:Grp75(gene name synonym)|uniprotkb:Hsp74(gene name synonym)|uniprotkb:Hspa9a(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_034611.2|ensembl:ENSMUSG00000024359(gene)|ensembl:ENSMUST00000025217(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043209"(myelin sheath)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1903707"(negative regulation of hemopoiesis)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P38647|reactome:R-MMU-3371453	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:HyohIe5BGD5mW3UO0OekqUKOhbU10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P63017	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-433443|uniprotkb:P08109|uniprotkb:P12225|uniprotkb:Q3U6R0|uniprotkb:Q3U764|uniprotkb:Q3U7D7|uniprotkb:Q3U7E2|uniprotkb:Q3U9B4|uniprotkb:Q3U9G0|uniprotkb:Q3UGM0|uniprotkb:Q5FWJ6|uniprotkb:Q62373|uniprotkb:Q62374|uniprotkb:Q62375|uniprotkb:Q6NZD0|ensembl:ENSMUSP00000015800	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:hsp7c_mouse(display_long)|uniprotkb:Heat shock 70 kDa protein 8(gene name synonym)|uniprotkb:Hspa8(gene name)|psi-mi:Hspa8(display_short)|uniprotkb:Hsc70(gene name synonym)|uniprotkb:Hsc73(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_112442.2|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031686"(A1 adenosine receptor binding)|go:"GO:0031906"(late endosome lumen)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042277"(peptide binding)|go:"GO:0042470"(melanosome)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043209"(myelin sheath)|go:"GO:0043531"(ADP binding)|go:"GO:0043624"|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044309"(neuron spine)|go:"GO:0044788"(modulation by host of viral process)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0030425"(dendrite)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072318"(clathrin coat disassembly)|go:"GO:0097214"(positive regulation of lysosomal membrane permeability)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099634"(postsynaptic specialization membrane)|go:"GO:0101031"(chaperone complex)|go:"GO:0140545"(protein disaggregase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902904"(negative regulation of supramolecular fiber organization)|go:"GO:1904592"(positive regulation of protein refolding)|go:"GO:1904593"(prostaglandin binding)|go:"GO:1904764"(chaperone-mediated autophagy translocation complex disassembly)|go:"GO:0061740"(protein targeting to lysosome involved in chaperone-mediated autophagy)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0061738"(late endosomal microautophagy)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006397"(mRNA processing)|go:"GO:0006457"(protein folding)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008380"(RNA splicing)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0005681"(spliceosomal complex)|reactome:R-MMU-3371568|reactome:R-MMU-3371571|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-450408|reactome:R-MMU-6798695|reactome:R-MMU-72163|reactome:R-MMU-8856828|reactome:R-MMU-8876725|reactome:R-MMU-888590|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990832"(slow axonal transport)|go:"GO:1990833"(clathrin-uncoating ATPase activity)|go:"GO:1990836"(lysosomal matrix)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P63017|rcsb pdb:3CQX|reactome:R-MMU-3371453|reactome:R-MMU-3371497|ensembl:ENSMUSG00000015656(gene)|ensembl:ENSMUST00000015800(transcript)|go:"GO:0000974"(Prp19 complex)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003723"(RNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|dip:DIP-32353N	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:WDnUczLfoe3ODQbiEITN3DfQnFA10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P51863	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-769989|uniprotkb:Q54A57|uniprotkb:Q9QWJ2|ensembl:ENSMUSP00000013304	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:va0d1_mouse(display_long)|uniprotkb:Vacuolar proton pump subunit d 1(gene name synonym)|uniprotkb:V-ATPase AC39 subunit(gene name synonym)|uniprotkb:V-ATPase 40 kDa accessory protein(gene name synonym)|uniprotkb:P39(gene name synonym)|uniprotkb:Physophilin(gene name synonym)|uniprotkb:Atp6v0d1(gene name)|psi-mi:Atp6v0d1(display_short)|uniprotkb:Atp6d(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_038505.2|ensembl:ENSMUSG00000013160(gene)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005813"(centrosome)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007034"(vacuolar transport)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0007420"(brain development)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033179"(proton-transporting V-type ATPase, V0 domain)|go:"GO:0033181"(plasma membrane proton-transporting V-type ATPase complex)|go:"GO:0036295"(cellular response to increased oxygen levels)|go:"GO:0043005"(neuron projection)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0060271"(cilium assembly)|interpro:IPR002843(ATPase, V0/A0 complex, subunit C/D)|interpro:IPR016727(ATPase, V0 complex, subunit D)|interpro:IPR035067|interpro:IPR036079|interpro:IPR044911|mint:P51863|reactome:R-MMU-1222556|reactome:R-MMU-77387|reactome:R-MMU-917977|reactome:R-MMU-9639288|reactome:R-MMU-983712|ensembl:ENSMUST00000013304(transcript)	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:XxeN6m831kNCB989OtmNfbjUvlo10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q9Z2U0	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-991701|ensembl:ENSMUSP00000029082	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:psa7_mouse(display_long)|uniprotkb:Proteasome subunit RC6-1(gene name synonym)|uniprotkb:Psma7(gene name)|psi-mi:Psma7(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	reactome:R-MMU-2467813|reactome:R-MMU-2871837|reactome:R-MMU-349425|reactome:R-MMU-350562|reactome:R-MMU-382556|reactome:R-MMU-450408|reactome:R-MMU-4608870|reactome:R-MMU-4641257|reactome:R-MMU-4641258|reactome:R-MMU-5358346|reactome:R-MMU-5607761|reactome:R-MMU-5607764|reactome:R-MMU-5610780|reactome:R-MMU-5610785|reactome:R-MMU-5632684|reactome:R-MMU-5658442|reactome:R-MMU-5668541|reactome:R-MMU-5676590|reactome:R-MMU-5687128|reactome:R-MMU-5689603|reactome:R-MMU-5689880|reactome:R-MMU-68827|reactome:R-MMU-68949|reactome:R-MMU-69017|reactome:R-MMU-69481|reactome:R-MMU-69601|reactome:R-MMU-75815|reactome:R-MMU-8852276|reactome:R-MMU-8854050|reactome:R-MMU-8932339|reactome:R-MMU-8939236|reactome:R-MMU-8939902|reactome:R-MMU-8941858|reactome:R-MMU-8948751|reactome:R-MMU-8951664|reactome:R-MMU-9020702|reactome:R-MMU-983168|reactome:R-MMU-202424|ensembl:ENSMUSG00000027566(gene)|ensembl:ENSMUST00000029082(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0019773"(proteasome core complex, alpha-subunit complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0098794"(postsynapse)|interpro:IPR000426(Proteasome alpha-subunit, conserved site)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR023332|interpro:IPR029055|interpro:IPR035190|mint:Q9Z2U0|rcsb pdb:3UNB|rcsb pdb:3UNE|rcsb pdb:3UNF|rcsb pdb:3UNH|reactome:R-MMU-1169091|reactome:R-MMU-1234176|reactome:R-MMU-1236978|reactome:R-MMU-174084|reactome:R-MMU-174154|reactome:R-MMU-174178|reactome:R-MMU-174184|reactome:R-MMU-187577|reactome:R-MMU-195253|refseq:NP_036099.1	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:eiU3Xagm8PsM8P5RAvaY60lPuGY10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P10518	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634066|uniprotkb:Q3THV6|ensembl:ENSMUSP00000030090|ensembl:ENSMUSP00000103068	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:hem2_mouse(display_long)|uniprotkb:Alad(gene name)|psi-mi:Alad(display_short)|uniprotkb:Lv(gene name synonym)|uniprotkb:Porphobilinogen synthase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_032551.3|refseq:XP_006537702.1|refseq:NP_001263375.1|ensembl:ENSMUSG00000028393(gene)|ensembl:ENSMUST00000030090(transcript)|ensembl:ENSMUST00000107444(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004655"(porphobilinogen synthase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0006782"(protoporphyrinogen IX biosynthetic process)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007584"(response to nutrient)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009635"(response to herbicide)|go:"GO:0010033"(response to organic substance)|go:"GO:0010038"(response to metal ion)|go:"GO:0010039"(response to iron ion)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010044"(response to aluminum ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010266"(response to vitamin B1)|go:"GO:0010269"(response to selenium ion)|go:"GO:0014823"(response to activity)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033197"(response to vitamin E)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043200"(response to amino acid)|go:"GO:0045471"(response to ethanol)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046689"(response to mercury ion)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051597"(response to methylmercury)|go:"GO:0070541"(response to platinum ion)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071284"(cellular response to lead ion)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1904854"(proteasome core complex binding)|interpro:IPR001731(Tetrapyrrole biosynthesis, porphobilinogen synthase)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR030656|mint:P10518|rcsb pdb:2Z0I|rcsb pdb:2Z1B|reactome:R-MMU-189451|reactome:R-MMU-6798695	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:NhU2SJjS9uO8bs14ufdf3+i8wTc10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P03995	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634365|uniprotkb:Q80VX6|uniprotkb:Q925K2|uniprotkb:Q925K3|uniprotkb:A1E2H7|uniprotkb:A2AH87|uniprotkb:Q09J71|uniprotkb:Q3USS4|uniprotkb:Q496R4|uniprotkb:Q496S3|uniprotkb:Q7TQ30|ensembl:ENSMUSP00000064691|uniprotkb:B2RTI7	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:gfap_mouse(display_long)|uniprotkb:Gfap(gene name)|psi-mi:Gfap(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_001124492.1|refseq:NP_034407.2|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0009611"(response to wounding)|go:"GO:0010467"(gene expression)|ensembl:ENSMUSG00000020932(gene)|ensembl:ENSMUST00000067444(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0010625"(positive regulation of Schwann cell proliferation)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014002"(astrocyte development)|go:"GO:0016020"(membrane)|go:"GO:0019900"(kinase binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031102"(neuron projection regeneration)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043209"(myelin sheath)|go:"GO:0044297"(cell body)|go:"GO:0045103"(intermediate filament-based process)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0051580"(regulation of neurotransmitter uptake)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070779"(D-aspartate import across plasma membrane)|go:"GO:0097386"(glial cell projection)|go:"GO:0097449"(astrocyte projection)|go:"GO:0097450"(astrocyte end-foot)|go:"GO:0098574"(cytoplasmic side of lysosomal membrane)|dip:DIP-1084N|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR027701|interpro:IPR039008|mint:P03995	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:y7+aINs6vTxOHokkQCqgejlZfh010090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P60710	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-353957|ensembl:ENSMUSP00000098066|uniprotkb:P02570|uniprotkb:P70514|uniprotkb:P99021|uniprotkb:Q11211|uniprotkb:Q3TI89|uniprotkb:Q3TVP6|uniprotkb:Q64316|uniprotkb:Q6ZWM3	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:actb_mouse(display_long)|uniprotkb:Actb(gene name)|psi-mi:Actb(display_short)|uniprotkb:Beta-actin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	ensembl:ENSMUSG00000029580(gene)|ensembl:ENSMUST00000100497(transcript)|refseq:NP_031419.1|go:"GO:0002102"(podosome)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007409"(axonogenesis)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030424"(axon)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030957"(Tat protein binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0071896"(protein localization to adherens junction)|go:"GO:0072749"(cellular response to cytochalasin B)|go:"GO:0097433"(dense body)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0150111"(regulation of transepithelial transport)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1904030"(negative regulation of cyclin-dependent protein kinase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|interpro:IPR043129|mint:P60710|reactome:R-MMU-190873|reactome:R-MMU-196025|reactome:R-MMU-2029482|reactome:R-MMU-3928662|reactome:R-MMU-418990|reactome:R-MMU-437239|reactome:R-MMU-4420097|reactome:R-MMU-445095|reactome:R-MMU-446353|reactome:R-MMU-5250924|reactome:R-MMU-5626467|reactome:R-MMU-5663213|reactome:R-MMU-5663220|reactome:R-MMU-5674135|reactome:R-MMU-5689603|reactome:R-MMU-5696394|reactome:R-MMU-8856828|reactome:R-MMU-9035034|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043296"(apical junction complex)|go:"GO:0044305"(calyx of Held)|go:"GO:0045121"(membrane raft)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048870"(cell motility)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0070160"(tight junction)|go:"GO:0001725"(stress fiber)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|dip:DIP-31574N	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:Hoge1B8Pn56kvbNTpkSLsQuHwRc10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P19246	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634658|uniprotkb:A1E2H9|uniprotkb:Q5SVF6|uniprotkb:Q61959|ensembl:ENSMUSP00000091061	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:nfh_mouse(display_long)|uniprotkb:Nefh(gene name)|psi-mi:Nefh(display_short)|uniprotkb:Kiaa0845(gene name synonym)|uniprotkb:Nfh(gene name synonym)|uniprotkb:Neurofilament triplet H protein(gene name synonym)|uniprotkb:200 kDa neurofilament protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_035034.2|ensembl:ENSMUSG00000020396(gene)|ensembl:ENSMUST00000093369(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001552"(ovarian follicle atresia)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0005883"(neurofilament)|go:"GO:0007420"(brain development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015643"(toxic substance binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031103"(axon regeneration)|go:"GO:0033693"(neurofilament bundle assembly)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043209"(myelin sheath)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045110"(intermediate filament bundle assembly)|go:"GO:0048936"(peripheral nervous system neuron axonogenesis)|go:"GO:0060052"(neurofilament cytoskeleton organization)|go:"GO:0061564"(axon development)|go:"GO:0097418"(neurofibrillary tangle)|go:"GO:0097440"(apical dendrite)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099160"(postsynaptic intermediate filament cytoskeleton)|go:"GO:0099184"(structural constituent of postsynaptic intermediate filament cytoskeleton)|go:"GO:0150017"(basal proximal dendrite)|go:"GO:1902513"(regulation of organelle transport along microtubule)|go:"GO:1903935"(response to sodium arsenite)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR010790(Protein of unknown function DUF1388)|interpro:IPR018039|interpro:IPR033183|interpro:IPR039008|mint:P19246	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:1Fs10v+/s87EA3iRKeuxNEijJ5o10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q99LX0	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634273|uniprotkb:O88306|uniprotkb:Q3THB9|uniprotkb:Q3U509|ensembl:ENSMUSP00000030805|ensembl:ENSMUSP00000101298|ensembl:ENSMUSP00000101299|ensembl:ENSMUSP00000101300	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:park7_mouse(display_long)|uniprotkb:Park7(gene name)|psi-mi:Park7(display_short)|uniprotkb:Protein/nucleic acid deglycase DJ-1(gene name synonym)|uniprotkb:Maillard deglycase(gene name synonym)|uniprotkb:Parkinsonism-associated deglycase(gene name synonym)|uniprotkb:Protein DJ-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_065594.2|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904782"(negative regulation of NMDA glutamate receptor activity)|go:"GO:1905259"(negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1905516"(positive regulation of fertilization)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990422"("glyoxalase (glycolic acid-forming) activity")|go:"GO:2000157"(negative regulation of ubiquitin-specific protease activity)|go:"GO:2000277"(positive regulation of oxidative phosphorylation uncoupler activity)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000825"(positive regulation of androgen receptor activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001268"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR002818(ThiJ/PfpI)|interpro:IPR006287(DJ-1)|interpro:IPR029062|mint:Q99LX0|reactome:R-MMU-3899300|reactome:R-MMU-9646399|ensembl:ENSMUSG00000028964(gene)|ensembl:ENSMUST00000030805(transcript)|ensembl:ENSMUST00000105673(transcript)|ensembl:ENSMUST00000105674(transcript)|ensembl:ENSMUST00000105675(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0002866"(positive regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006517"(protein deglycosylation)|go:"GO:0006914"(autophagy)|go:"GO:0006954"(inflammatory response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007338"(single fertilization)|go:"GO:0008233"(peptidase activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010273"(detoxification of copper ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016532"(superoxide dismutase copper chaperone activity)|go:"GO:0016570"(histone modification)|go:"GO:0016605"(PML body)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0019249"(lactate biosynthetic process)|go:"GO:0019826"(oxygen sensor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0030073"(insulin secretion)|go:"GO:0030424"(axon)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035065"(regulation of histone acetylation)|go:"GO:0036470"(tyrosine 3-monooxygenase activator activity)|go:"GO:0036471"(cellular response to glyoxal)|go:"GO:0036478"(L-dopa decarboxylase activator activity)|go:"GO:0036524"(protein deglycase activity)|go:"GO:0036526"(peptidyl-cysteine deglycation)|go:"GO:0036527"(peptidyl-arginine deglycation)|go:"GO:0036528"(peptidyl-lysine deglycation)|go:"GO:0036529"(protein deglycation, glyoxal removal)|go:"GO:0036530"(protein deglycation, methylglyoxal removal)|go:"GO:0036531"(glutathione deglycation)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044297"(cell body)|go:"GO:0044388"(small protein activating enzyme binding)|go:"GO:0044390"(ubiquitin-like protein conjugating enzyme binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045340"(mercury ion binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046295"(glycolate biosynthetic process)|go:"GO:0046826"(negative regulation of protein export from nucleus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050787"(detoxification of mercury ion)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051920"(peroxiredoxin activity)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0061727"(methylglyoxal catabolic process to lactate)|go:"GO:0061827"(sperm head)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070994"(detection of oxidative stress)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098793"(presynapse)|go:"GO:0106044"(guanine deglycation)|go:"GO:0106045"(guanine deglycation, methylglyoxal removal)|go:"GO:0106046"(guanine deglycation, glyoxal removal)|go:"GO:0110095"(cellular detoxification of aldehyde)|go:"GO:0140041"(cellular detoxification of methylglyoxal)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902177"(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903094"(negative regulation of protein K48-linked deubiquitination)|go:"GO:1903122"(negative regulation of TRAIL-activated apoptotic signaling pathway)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903168"(positive regulation of pyrroline-5-carboxylate reductase activity)|go:"GO:1903178"(positive regulation of tyrosine 3-monooxygenase activity)|go:"GO:1903181"(positive regulation of dopamine biosynthetic process)|go:"GO:1903189"(glyoxal metabolic process)|go:"GO:1903197"(positive regulation of L-dopa biosynthetic process)|go:"GO:1903200"(positive regulation of L-dopa decarboxylase activity)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903384"(negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:dfkL4WeM+WgrYJa3aYTWbFyi0bk10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q8BWT1	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634016|uniprotkb:Q8JZR8|intact:EBI-4285676|uniprotkb:Q3TIT9|ensembl:ENSMUSP00000037348	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:thim_mouse(display_long)|uniprotkb:Acyl-CoA hydrolase, mitochondrial(gene name synonym)|uniprotkb:Acetyl-CoA acetyltransferase(gene name synonym)|uniprotkb:Acaa2(gene name)|psi-mi:Acaa2(display_short)|uniprotkb:Acetyl-CoA acyltransferase(gene name synonym)|uniprotkb:Beta-ketothiolase(gene name synonym)|uniprotkb:Mitochondrial 3-oxoacyl-CoA thiolase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_803421.1|ensembl:ENSMUSG00000036880(gene)|ensembl:ENSMUST00000041053(transcript)|go:"GO:0003985"(acetyl-CoA C-acetyltransferase activity)|go:"GO:0003986"(acetyl-CoA hydrolase activity)|go:"GO:0003988"(acetyl-CoA C-acyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006084"(acetyl-CoA metabolic process)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0047617"(acyl-CoA hydrolase activity)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0102991"(myristoyl-CoA hydrolase activity)|go:"GO:1901029"(negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1902109"(negative regulation of mitochondrial membrane permeability involved in apoptotic process)|interpro:IPR002155(Thiolase)|interpro:IPR016039(Thiolase-like)|interpro:IPR020610|interpro:IPR020613|interpro:IPR020615|interpro:IPR020616|interpro:IPR020617|mint:Q8BWT1|reactome:R-MMU-77289	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:15aWO97WJBNGYD449bAgjVjkgTY10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:O08553	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-446064|uniprotkb:Q6P5D0|ensembl:ENSMUSP00000022629	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:dpyl2_mouse(display_long)|uniprotkb:Unc-33-like phosphoprotein 2(gene name synonym)|uniprotkb:Dpysl2(gene name)|psi-mi:Dpysl2(display_short)|uniprotkb:Crmp2(gene name synonym)|uniprotkb:Ulip2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_034085.2|ensembl:ENSMUSG00000022048(gene)|ensembl:ENSMUST00000022629(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007411"(axon guidance)|go:"GO:0008017"(microtubule binding)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0016810"("hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds")|go:"GO:0019901"(protein kinase binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043209"(myelin sheath)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0098793"(presynapse)|interpro:IPR006680(Amidohydrolase 1)|interpro:IPR011059(Metal-dependent hydrolase, composite)|interpro:IPR011778(D-hydantoinase)|interpro:IPR030615|interpro:IPR032466|mint:O08553|rcsb pdb:5UQC|reactome:R-MMU-399956|reactome:R-MMU-437239	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:97yc8TNEPMcGtGNRLvl+KV+DYr010090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P27773	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1183750|uniprotkb:Q3TEI9|uniprotkb:Q3TIL2|uniprotkb:Q3UZK8|uniprotkb:Q8C2F4|uniprotkb:Q99LF6|ensembl:ENSMUSP00000028683	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:pdia3_mouse(display_long)|uniprotkb:Pdia3(gene name)|psi-mi:Pdia3(display_short)|uniprotkb:Erp(gene name synonym)|uniprotkb:Erp60(gene name synonym)|uniprotkb:Grp58(gene name synonym)|uniprotkb:Disulfide isomerase ER-60(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 60(gene name synonym)|uniprotkb:58 kDa microsomal protein(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 57(gene name synonym)|uniprotkb:58 kDa glucose-regulated protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_031978.2|ensembl:ENSMUSG00000027248(gene)|ensembl:ENSMUST00000028683(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0008233"(peptidase activity)|go:"GO:0009986"(cell surface)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0043209"(myelin sheath)|go:"GO:0019153"("protein-disulfide reductase (glutathione) activity")|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR005788(Disulphide isomerase)|go:"GO:0042470"(melanosome)|interpro:IPR005792(Protein disulphide isomerase)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017937|go:"GO:0042802"(identical protein binding)|interpro:IPR036249|go:"GO:0042824"(MHC class I peptide loading complex)|interpro:IPR041868|mint:P27773|reactome:R-MMU-1236974|reactome:R-MMU-901042|reactome:R-MMU-983170|go:"GO:0042825"(TAP complex)	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:cG7tGYAi8ElGXs7VmhY3M63GiRc10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q60864	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-494437|uniprotkb:Q3TT16|uniprotkb:Q8BPH3|uniprotkb:Q99L66|ensembl:ENSMUSP00000025918	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:stip1_mouse(display_long)|uniprotkb:Hsc70/Hsp90-organizing protein(gene name synonym)|uniprotkb:Stip1(gene name)|psi-mi:Stip1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_058017.1|ensembl:ENSMUSG00000024966(gene)|ensembl:ENSMUST00000025918(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043209"(myelin sheath)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0101031"(chaperone complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR041243|mint:Q60864|reactome:R-MMU-3371497|reactome:R-MMU-9696273	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:f6DTvAcA6tKSLqzw11r9X+rC8ao10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:O35639	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634076|uniprotkb:Q3UBI0|ensembl:ENSMUSP00000031447	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:anxa3_mouse(display_long)|uniprotkb:Anxa3(gene name)|psi-mi:Anxa3(display_short)|uniprotkb:Anx3(gene name synonym)|uniprotkb:35-alpha calcimedin(gene name synonym)|uniprotkb:Annexin III(gene name synonym)|uniprotkb:Annexin-3(gene name synonym)|uniprotkb:Lipocortin III(gene name synonym)|uniprotkb:Placental anticoagulant protein III(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_038498.2|ensembl:ENSMUSG00000029484(gene)|ensembl:ENSMUST00000031447(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0019834"(phospholipase A2 inhibitor activity)|go:"GO:0021766"(hippocampus development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0042581"(specific granule)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043312"(neutrophil degranulation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051054"(positive regulation of DNA metabolic process)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070848"(response to growth factor)|interpro:IPR001464(Annexin)|interpro:IPR002390(Annexin, type III)|interpro:IPR018252|interpro:IPR018502|interpro:IPR037104|mint:O35639	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:OuaFUOJqepCNgHjT1UZQtUDfJdI10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P16125	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-444932|uniprotkb:Q545Y4|ensembl:ENSMUSP00000032373|ensembl:ENSMUSP00000159362	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:ldhb_mouse(display_long)|uniprotkb:LDH heart subunit(gene name synonym)|uniprotkb:Ldhb(gene name)|psi-mi:Ldhb(display_short)|uniprotkb:Ldh-2(gene name synonym)|uniprotkb:Ldh2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_032518.1|refseq:NP_001303251.1|ensembl:ENSMUSG00000030246(gene)|ensembl:ENSMUST00000032373(transcript)|ensembl:ENSMUST00000239397(transcript)|go:"GO:0004457"(lactate dehydrogenase activity)|go:"GO:0004459"(L-lactate dehydrogenase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006089"(lactate metabolic process)|go:"GO:0019244"(lactate biosynthetic process from pyruvate)|go:"GO:0019674"(NAD metabolic process)|go:"GO:0019900"(kinase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0045121"(membrane raft)|go:"GO:0051287"(NAD binding)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR011304(L-lactate dehydrogenase)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR018177|interpro:IPR022383|interpro:IPR036291|mint:P16125|reactome:R-MMU-70268|interpro:IPR001557(L-lactate/malate dehydrogenase)|refseq:NP_001289694.1	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:jN0wT7b/jHBnWCfV48irZYeGxa410090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P35979	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634002|uniprotkb:Q9CQK4|ensembl:ENSMUSP00000117461	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:rl12_mouse(display_long)|uniprotkb:Rpl12(gene name)|psi-mi:Rpl12(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_033102.2|ensembl:ENSMUSG00000038900(gene)|ensembl:ENSMUST00000126610(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015934"(large ribosomal subunit)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0070180"(large ribosomal subunit rRNA binding)|interpro:IPR000911(Ribosomal protein L11)|interpro:IPR020783|interpro:IPR020784|interpro:IPR020785|interpro:IPR036769|interpro:IPR036796|mint:P35979|rcsb pdb:1WIB|reactome:R-MMU-156827|reactome:R-MMU-1799339|reactome:R-MMU-6791226|reactome:R-MMU-72689|reactome:R-MMU-72706|reactome:R-MMU-975956|reactome:R-MMU-975957	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:elKEi15MO82sKMmT/YFoHw+8SZI10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q5D0B0	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634464	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:q5d0b0_mouse(display_long)|uniprotkb:Lrpap1(gene name)|psi-mi:Lrpap1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	interpro:IPR010483(Alpha-2-macroglobulin RAP, C-terminal)|interpro:IPR009066(Alpha-2-macroglobulin receptor-associated protein, domain 1)|interpro:IPR036744|interpro:IPR037999|interpro:IPR038001|interpro:IPR038003|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0008201"(heparin binding)|go:"GO:0048019"(receptor antagonist activity)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:kLWOzOcxfY/38QQwRamwz2G0DV810090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q02819	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634689|uniprotkb:Q3TU42|uniprotkb:Q9CWA1|uniprotkb:Q9D8J4|uniprotkb:Q9DBL3|ensembl:ENSMUSP00000147383	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:nucb1_mouse(display_long)|uniprotkb:Nucb1(gene name)|psi-mi:Nucb1(display_short)|uniprotkb:Nuc(gene name synonym)|uniprotkb:Nucb(gene name synonym)|uniprotkb:CALNUC(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_001157134.1|refseq:NP_032775.1|refseq:XP_017177513.1|refseq:XP_006540759.1|ensembl:ENSMUSG00000030824(gene)|ensembl:ENSMUST00000211765(transcript)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0003677"(DNA binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0072718"(response to cisplatin)|go:"GO:0090498"(extrinsic component of Golgi membrane)|go:"GO:0098547"(lumenal side of Golgi membrane)|go:"GO:1903533"(regulation of protein targeting)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR040250|interpro:IPR040253|mint:Q02819|reactome:R-MMU-381426|reactome:R-MMU-8957275|go:"GO:0005794"(Golgi apparatus)	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:/Iqiy8TmMklf3hIyYKPce37SBP010090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P97457	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634612|ensembl:ENSMUSP00000032910	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:mlrs_mouse(display_long)|uniprotkb:Mylpf(gene name)|psi-mi:Mylpf(display_short)|uniprotkb:Fast skeletal myosin light chain 2(gene name synonym)|uniprotkb:MLC2F(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_058034.1|ensembl:ENSMUSG00000030672(gene)|ensembl:ENSMUST00000032910(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0006955"(immune response)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0016459"(myosin complex)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:P97457|rcsb pdb:7NEP|reactome:R-MMU-445355	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:7o5XhFupODE4Hfr/C77i4KkywmM10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q9DCW4	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634288|uniprotkb:Q810V3|ensembl:ENSMUSP00000004729	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:etfb_mouse(display_long)|uniprotkb:Etfb(gene name)|psi-mi:Etfb(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_080971.2|ensembl:ENSMUSG00000004610(gene)|ensembl:ENSMUST00000004729(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0009055"(electron transfer activity)|go:"GO:0017133"(mitochondrial electron transfer flavoprotein complex)|go:"GO:0033539"(fatty acid beta-oxidation using acyl-CoA dehydrogenase)|interpro:IPR000049(Electron transfer flavoprotein, beta-subunit, core)|interpro:IPR012255(Electron transfer flavoprotein, beta subunit)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR014730(Electron transfer flavoprotein, alpha/beta-subunit, N-terminal)|interpro:IPR033948|mint:Q9DCW4|reactome:R-MMU-611105|reactome:R-MMU-8876725	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:eCcG+jkuQlxw/TzcOkzCBoAKJ8Y10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P61982	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-359843|uniprotkb:O70457|uniprotkb:P35214|uniprotkb:Q4FK44|uniprotkb:Q3UFD6|uniprotkb:Q9UDP2|uniprotkb:Q9UN99|ensembl:ENSMUSP00000051223|ensembl:ENSMUSP00000143631	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:1433g_mouse(display_long)|uniprotkb:Ywhag(gene name)|psi-mi:Ywhag(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_061359.2|ensembl:ENSMUSG00000051391(gene)|ensembl:ENSMUST00000055808(transcript)|ensembl:ENSMUST00000198270(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0006605"(protein targeting)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031982"(vesicle)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0045202"(synapse)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0098793"(presynapse)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P61982|reactome:R-MMU-111447|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-8854518|reactome:R-MMU-9614399	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:u1cd71h0RPgTOEMrQVhOelsxWnM10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q60932	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-299577|ensembl:ENSMUSP00000020673|uniprotkb:Q5SVC6|uniprotkb:B1ASZ9	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:vdac1_mouse(display_long)|uniprotkb:Vdac1(gene name)|psi-mi:Vdac1(display_short)|uniprotkb:Vdac5(gene name synonym)|uniprotkb:Voltage-dependent anion-selective channel protein 5(gene name synonym)|uniprotkb:Outer mitochondrial membrane protein porin 1(gene name synonym)|uniprotkb:Plasmalemmal porin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	go:"GO:0001662"(behavioral fear response)|go:"GO:0005253"(anion channel activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008308"(voltage-gated anion channel activity)|go:"GO:0015288"(porin activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031966"(mitochondrial membrane)|ensembl:ENSMUSG00000020402(gene)|ensembl:ENSMUST00000020673(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043209"(myelin sheath)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0097001"(ceramide binding)|go:"GO:0110099"(negative regulation of calcium import into the mitochondrion)|go:"GO:1901526"(positive regulation of mitophagy)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR001925(Porin, eukaryotic type)|interpro:IPR023614|interpro:IPR027246|interpro:IPR030270|mint:Q60932|rcsb pdb:3EMN|rcsb pdb:4C69|rcsb pdb:7KUH|reactome:R-MMU-5205685|reactome:R-MMU-5689880|reactome:R-MMU-70268|go:"GO:0042802"(identical protein binding)|refseq:NP_035824.1	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:bULLXFpcR97WYvb2Pc7kDU9n31w10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q99N28	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634486|uniprotkb:Q8BSQ8|uniprotkb:Q8K1H8|ensembl:ENSMUSP00000106851	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:cadm3_mouse(display_long)|uniprotkb:Cadm3(gene name)|psi-mi:Cadm3(display_short)|uniprotkb:Igsf4b(gene name synonym)|uniprotkb:Necl1(gene name synonym)|uniprotkb:Syncam3(gene name synonym)|uniprotkb:Tsll1(gene name synonym)|uniprotkb:Immunoglobulin superfamily member 4B(gene name synonym)|uniprotkb:Nectin-like protein 1(gene name synonym)|uniprotkb:TSLC1-like protein 1(gene name synonym)|uniprotkb:Synaptic cell adhesion molecule 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_444429.1|ensembl:ENSMUSG00000005338(gene)|ensembl:ENSMUST00000111220(transcript)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0008104"(protein localization)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q99N28|rcsb pdb:5ZO2|reactome:R-MMU-418990|reactome:R-MMU-420597	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:ktQC5GetNtKXBJB0nSCEttb1neY10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P07759	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-527318|uniprotkb:Q62257|uniprotkb:Q8VCH3|uniprotkb:Q91W80|uniprotkb:Q91X80	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:spa3k_mouse(display_long)|uniprotkb:Contrapsin(gene name synonym)|uniprotkb:SPI-2(gene name synonym)|uniprotkb:Serpina3k(gene name)|psi-mi:Serpina3k(display_short)|uniprotkb:Mcm2(gene name synonym)|uniprotkb:Spi2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	interpro:IPR042178|interpro:IPR042185|interpro:IPR036186|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0034097"(response to cytokine)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0062023"(collagen-containing extracellular matrix)|refseq:NP_035588.2|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR023795|interpro:IPR023796|mint:P07759	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:Mw34ptn1r1vYkkikLF0wyI/1rR410090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P48678-1	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-303687|ensembl:ENSMUSP00000029699	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:p48678-1(display_long)|uniprotkb:Lmna(gene name)|psi-mi:Lmna(display_short)|uniprotkb:Lmn1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	ensembl:ENSMUSG00000028063(gene)|ensembl:ENSMUST00000029699(transcript)|intact:EBI-299212(lamc_mouse)	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:bJz9o/dZoD9E4CRP1FLYihybpwA10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P18760	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1183994|ensembl:ENSMUSP00000147514	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:cof1_mouse(display_long)|uniprotkb:Cfl1(gene name)|psi-mi:Cfl1(display_short)|uniprotkb:Cofilin, non-muscle isoform(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_031713.1|ensembl:ENSMUSG00000056201(gene)|ensembl:ENSMUST00000209469(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001842"(neural fold formation)|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010593"(negative regulation of lamellipodium assembly)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030043"(actin filament fragmentation)|go:"GO:0030175"(filopodium)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030426"(growth cone)|go:"GO:0030835"(negative regulation of actin filament depolymerization)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031252"(cell leading edge)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032587"(ruffle membrane)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043200"(response to amino acid)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048870"(cell motility)|go:"GO:0051014"(actin filament severing)|go:"GO:0051015"(actin filament binding)|go:"GO:0051293"(establishment of spindle localization)|go:"GO:0051511"(negative regulation of unidimensional cell growth)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090732"(cofilin-actin rod)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902936"(phosphatidylinositol bisphosphate binding)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1905873"(positive regulation of protein localization to cell leading edge)|go:"GO:1905875"(negative regulation of postsynaptic density organization)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000784"(positive regulation of establishment of cell polarity regulating cell shape)|go:"GO:2000814"(positive regulation of barbed-end actin filament capping)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR017904|interpro:IPR027234|interpro:IPR029006|mint:P18760|dip:DIP-38073N	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:nw/9u2+2nq9Ef43SapV43MeOtjE10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q91X72	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634454|uniprotkb:P97824|uniprotkb:Q8WUP0|uniprotkb:Q3UKP2|ensembl:ENSMUSP00000033185	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:hemo_mouse(display_long)|uniprotkb:Hpx(gene name)|psi-mi:Hpx(display_short)|uniprotkb:Hpxn(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_059067.2|ensembl:ENSMUSG00000030895(gene)|ensembl:ENSMUST00000033185(transcript)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0005615"(extracellular space)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0015232"(heme transmembrane transporter activity)|go:"GO:0020027"(hemoglobin metabolic process)|go:"GO:0020037"(heme binding)|go:"GO:0042168"(heme metabolic process)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0046872"(metal ion binding)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0060332"(positive regulation of response to interferon-gamma)|go:"GO:0060335"(positive regulation of interferon-gamma-mediated signaling pathway)|interpro:IPR000585(Hemopexin)|interpro:IPR016358(Hemopexin, chordata)|interpro:IPR018486|interpro:IPR018487|interpro:IPR036375|mint:Q91X72|reactome:R-MMU-2168880	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:tHWUfB22U2a/+bQ2oAt2XVQFpFQ10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P04370	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-445092|uniprotkb:Q01585|uniprotkb:Q03139|uniprotkb:Q03176|uniprotkb:Q61836|uniprotkb:Q61837|uniprotkb:Q99KE4|uniprotkb:Q9QWP1|ensembl:ENSMUSP00000046185	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:mbp_mouse(display_long)|uniprotkb:Myelin A1 protein(gene name synonym)|uniprotkb:Mbp(gene name)|psi-mi:Mbp(display_short)|uniprotkb:Shi(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_001020416.1|refseq:NP_001020422.1|refseq:NP_001020425.1|refseq:NP_001020426.1|refseq:NP_001020427.1|refseq:NP_001020429.1|refseq:NP_001020430.1|refseq:NP_034907.1|ensembl:ENSMUSG00000041607(gene)|ensembl:ENSMUST00000047865(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002020"(protease binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0009636"(response to toxic substance)|go:"GO:0019911"(structural constituent of myelin sheath)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033269"(internode region of axon)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0043218"(compact myelin)|go:"GO:0061024"(membrane organization)|go:"GO:0071944"(cell periphery)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000548(Myelin basic protein)|go:"GO:0005516"(calmodulin binding)|mint:P04370|rcsb pdb:1U3H|rcsb pdb:2LUG	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:XdsMXnU1X6iC/n7Ynm19IyXwYsM10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P26443	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-773329|uniprotkb:Q8C273|ensembl:ENSMUSP00000022322	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:dhe3_mouse(display_long)|uniprotkb:Glud1(gene name)|psi-mi:Glud1(display_short)|uniprotkb:Glud(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_032159.1|ensembl:ENSMUSG00000021794(gene)|ensembl:ENSMUST00000022322(transcript)|go:"GO:0004352"("glutamate dehydrogenase (NAD+) activity")|go:"GO:0004353"("glutamate dehydrogenase [NAD(P)+] activity")|go:"GO:0004354"("glutamate dehydrogenase (NADP+) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006537"(glutamate biosynthetic process)|go:"GO:0006538"(glutamate catabolic process)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0007616"(long-term memory)|go:"GO:0010044"(response to aluminum ion)|go:"GO:0019899"(enzyme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0043531"(ADP binding)|go:"GO:0070403"(NAD+ binding)|go:"GO:0070728"(leucine binding)|go:"GO:0072350"(tricarboxylic acid metabolic process)|interpro:IPR006095(Glutamate/phenylalanine/leucine/valine dehydrogenase)|interpro:IPR006096(Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal)|interpro:IPR006097(Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation region)|interpro:IPR033524|interpro:IPR033922|interpro:IPR036291|mint:P26443|reactome:R-MMU-2151201|reactome:R-MMU-8964539	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:HbPeUm/tpMD6GrgM/863swTQqGA10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q9DCH4	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634316|uniprotkb:Q5XJV3|ensembl:ENSMUSP00000033342	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:eif3f_mouse(display_long)|uniprotkb:Eif3f(gene name)|psi-mi:Eif3f(display_short)|uniprotkb:Eif3s5(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 5(gene name synonym)|uniprotkb:eIF-3-epsilon(gene name synonym)|uniprotkb:eIF3 p47(gene name synonym)|uniprotkb:Deubiquitinating enzyme eIF3f(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_079620.2|dip:DIP-42766N|ensembl:ENSMUSG00000031029(gene)|ensembl:ENSMUST00000033342(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR027531|interpro:IPR037518|mint:Q9DCH4|reactome:R-MMU-156827|reactome:R-MMU-72649|reactome:R-MMU-72689|reactome:R-MMU-72695|reactome:R-MMU-72702|reactome:R-MMU-72706	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:RTpmhLHfvqVe3dkVb7fImMfdeTA10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q9JHU9	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634601|ensembl:ENSMUSP00000019283|ensembl:ENSMUSP00000148077	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:ino1_mouse(display_long)|uniprotkb:Isyna1(gene name)|psi-mi:Isyna1(display_short)|uniprotkb:Ino1(gene name synonym)|uniprotkb:Myo-inositol 1-phosphate synthase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_076116.1|ensembl:ENSMUSG00000019139(gene)|ensembl:ENSMUST00000019283(transcript)|ensembl:ENSMUST00000210005(transcript)|go:"GO:0004512"(inositol-3-phosphate synthase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006021"(inositol biosynthetic process)|go:"GO:0008654"(phospholipid biosynthetic process)|interpro:IPR002587(Myo-inositol-1-phosphate synthase)|interpro:IPR013021(Myo-inositol-1-phosphate synthase, GAPDH-like)|interpro:IPR036291|mint:Q9JHU9|reactome:R-MMU-1855183	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:2sC3BHRnI9YSxfIHmbuI27e0TJU10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q9D6R2	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-299873|ensembl:ENSMUSP00000127526|uniprotkb:Q3UAM8|uniprotkb:Q8C8A1|uniprotkb:Q9D1L1	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:idh3a_mouse(display_long)|uniprotkb:Idh3a(gene name)|psi-mi:Idh3a(display_short)|uniprotkb:Isocitric dehydrogenase subunit alpha(gene name synonym)|uniprotkb:"NAD(+)-specific ICDH subunit alpha"(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	ensembl:ENSMUSG00000032279(gene)|ensembl:ENSMUST00000167866(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004449"("isocitrate dehydrogenase (NAD+) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006102"(isocitrate metabolic process)|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0043209"(myelin sheath)|go:"GO:0051287"(NAD binding)|interpro:IPR004434(Isocitrate dehydrogenase NAD-dependent, mitochondrial)|interpro:IPR019818|interpro:IPR024084|mint:Q9D6R2|reactome:R-MMU-71403|refseq:NP_083849.1	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:JkEkbIT34WQdoOiBYA9kAao2lC010090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P46638	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634944|ensembl:ENSMUSP00000110021	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:rb11b_mouse(display_long)|uniprotkb:Rab11b(gene name)|psi-mi:Rab11b(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_033023.1|ensembl:ENSMUSG00000077450(gene)|ensembl:ENSMUST00000057373(transcript)|go:"GO:0001881"(receptor recycling)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0006887"(exocytosis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019003"(GDP binding)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031489"(myosin V binding)|go:"GO:0032402"(melanosome transport)|go:"GO:0032456"(endocytic recycling)|go:"GO:0033572"(transferrin transport)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0044070"(regulation of anion transport)|go:"GO:0045054"(constitutive secretory pathway)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0071468"(cellular response to acidic pH)|go:"GO:0090150"(establishment of protein localization to membrane)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2001135"(regulation of endocytic recycling)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P46638|reactome:R-MMU-8854214|reactome:R-MMU-8873719	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:McbcmcV5cB7IE3GFkiDNIB5WcsM10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P15331	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634736|uniprotkb:O35688|uniprotkb:O35689	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:peri_mouse(display_long)|uniprotkb:Prph(gene name)|psi-mi:Prph(display_short)|uniprotkb:Prph1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	mint:P15331|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR002957(Keratin, type I)|interpro:IPR039008|interpro:IPR027700|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005882"(intermediate filament)|go:"GO:0005883"(neurofilament)|go:"GO:0030424"(axon)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0044299"(C-fiber)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045098"(type III intermediate filament)|go:"GO:0045104"(intermediate filament cytoskeleton organization)	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:WWyVPUIRodlB+q1687sper/IPSg10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P16627	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1183684|uniprotkb:O88686|uniprotkb:Q61693|ensembl:ENSMUSP00000007248	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:hs71l_mouse(display_long)|uniprotkb:Heat shock 70 kDa-like protein 1(gene name synonym)|uniprotkb:Spermatid-specific heat shock protein 70(gene name synonym)|uniprotkb:Hspa1l(gene name)|psi-mi:Hspa1l(display_short)|uniprotkb:Hsc70t(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_038586.2|ensembl:ENSMUSG00000007033(gene)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030154"(cell differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|ensembl:ENSMUST00000007248(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0051787"(misfolded protein binding)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|reactome:R-MMU-3371453|reactome:R-MMU-3371497|reactome:R-MMU-3371568|reactome:R-MMU-3371571	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:9AyTRM+TusngYdweWsTK46QlIgk10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q61753	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1633989|uniprotkb:Q3TEE5|uniprotkb:Q75SV9|uniprotkb:Q8C603|ensembl:ENSMUSP00000064755	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:sera_mouse(display_long)|uniprotkb:Phgdh(gene name)|psi-mi:Phgdh(display_short)|uniprotkb:A10(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_058662.2|ensembl:ENSMUSG00000053398(gene)|ensembl:ENSMUST00000065793(transcript)|go:"GO:0004617"(phosphoglycerate dehydrogenase activity)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006544"(glycine metabolic process)|go:"GO:0006563"(L-serine metabolic process)|go:"GO:0006564"(L-serine biosynthetic process)|go:"GO:0006566"(threonine metabolic process)|go:"GO:0009448"(gamma-aminobutyric acid metabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0021510"(spinal cord development)|go:"GO:0021782"(glial cell development)|go:"GO:0021915"(neural tube development)|go:"GO:0022008"(neurogenesis)|go:"GO:0031175"(neuron projection development)|go:"GO:0043209"(myelin sheath)|go:"GO:0051287"(NAD binding)|go:"GO:0070314"(G1 to G0 transition)|interpro:IPR006139(D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region)|interpro:IPR006140(D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding)|interpro:IPR006236(D-3-phosphoglycerate dehydrogenase)|interpro:IPR029009|interpro:IPR029752|interpro:IPR029753|interpro:IPR036291|mint:Q61753|reactome:R-MMU-977347	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:66i2iIx5qSIN6BkqSPF14+UqDIA10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P21614	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1635283|uniprotkb:Q7TS97|uniprotkb:Q91XG1|uniprotkb:Q9CY31|ensembl:ENSMUSP00000046636	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:vtdb_mouse(display_long)|uniprotkb:Gc(gene name)|psi-mi:Gc(display_short)|uniprotkb:Group-specific component(gene name synonym)|uniprotkb:Gc-globulin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_032122.1|ensembl:ENSMUSG00000035540(gene)|ensembl:ENSMUST00000049209(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005499"(vitamin D binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030424"(axon)|go:"GO:0042359"(vitamin D metabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0090482"(vitamin transmembrane transporter activity)|go:"GO:1902118"(calcidiol binding)|interpro:IPR000213(Vitamin D-binding protein)|interpro:IPR000264(Serum albumin)|interpro:IPR014760(Serum albumin, N-terminal)|interpro:IPR015247(Vitamin D binding protein, domain III)|interpro:IPR020857|interpro:IPR020858|mint:P21614|reactome:R-MMU-196791	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:ifEDpexWmCpr5HKUCxI7KQtCJ5s10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P63260	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-351301|uniprotkb:P02571|uniprotkb:P14104|uniprotkb:P99022|ensembl:ENSMUSP00000071486|ensembl:ENSMUSP00000101822	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:actg_mouse(display_long)|uniprotkb:Actg1(gene name)|psi-mi:Actg1(display_short)|uniprotkb:Actg(gene name synonym)|uniprotkb:Gamma-actin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_033739.1|reactome:R-MMU-190873|reactome:R-MMU-196025|reactome:R-MMU-2029482|reactome:R-MMU-3928662|reactome:R-MMU-418990|reactome:R-MMU-437239|reactome:R-MMU-4420097|reactome:R-MMU-445095|reactome:R-MMU-446353|reactome:R-MMU-5626467|reactome:R-MMU-5663213|reactome:R-MMU-5663220|reactome:R-MMU-5674135|reactome:R-MMU-8856828|reactome:R-MMU-9013418|ensembl:ENSMUSG00000062825(gene)|ensembl:ENSMUST00000071555(transcript)|ensembl:ENSMUST00000106215(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005522"(profilin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030016"(myofibril)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0042802"(identical protein binding)|go:"GO:0043034"(costamere)|go:"GO:0043209"(myelin sheath)|go:"GO:0043296"(apical junction complex)|go:"GO:0044305"(calyx of Held)|go:"GO:0045177"(apical part of cell)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097433"(dense body)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0099143"(presynaptic actin cytoskeleton)|go:"GO:0120192"(tight junction assembly)|go:"GO:0120220"(basal body patch)|go:"GO:0150111"(regulation of transepithelial transport)|go:"GO:1902396"(protein localization to bicellular tight junction)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|interpro:IPR043129|reactome:R-MMU-114608	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:B2OOsE06lTfo90H3g8tlmUJQ7cY10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P68254	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-400675|uniprotkb:P35216|uniprotkb:Q3TW69|uniprotkb:Q3UJN5|uniprotkb:Q5SP76|uniprotkb:Q5U423|uniprotkb:Q66JR6|ensembl:ENSMUSP00000100067|ensembl:ENSMUSP00000123605	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:1433t_mouse(display_long)|uniprotkb:Ywhaq(gene name)|psi-mi:Ywhaq(display_short)|uniprotkb:14-3-3 protein tau(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_035869.1|ensembl:ENSMUSG00000076432(gene)|ensembl:ENSMUST00000103002(transcript)|ensembl:ENSMUST00000135088(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006605"(protein targeting)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034766"(negative regulation of ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0071889"(14-3-3 protein binding)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|interpro:IPR042584|mint:P68254|reactome:R-MMU-111447|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-9614399	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:l8bki6QJJEH5S5NIwQdm/MAYcc010090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q7TMI0	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634912	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:q7tmi0_mouse(display_long)|uniprotkb:Psmd11(gene name)|psi-mi:Psmd11(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR040773|interpro:IPR040780|interpro:IPR035295|interpro:IPR036390|go:"GO:0000502"(proteasome complex)|go:"GO:0043248"(proteasome assembly)	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:iHlH1u0ZLkv3nKIN7CGghi3WMpA10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P56480	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-299482|ensembl:ENSMUSP00000026459|uniprotkb:Q0QEP4|uniprotkb:Q3TFD7|uniprotkb:Q3TIP9|uniprotkb:Q3TK44|uniprotkb:Q3TWD5|uniprotkb:Q3TX28|uniprotkb:Q3U6U4|uniprotkb:Q3U774|uniprotkb:Q3UB69|uniprotkb:Q3UF69|uniprotkb:Q8CI65|uniprotkb:Q8VEJ5|uniprotkb:Q9CTI7|uniprotkb:Q9CWX7	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:atpb_mouse(display_long)|uniprotkb:Atp5f1b(gene name)|psi-mi:Atp5f1b(display_short)|uniprotkb:ATP synthase F1 subunit beta(gene name synonym)|uniprotkb:Atp5b(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	interpro:IPR024034|interpro:IPR027417|interpro:IPR036121|mint:P56480|reactome:R-MMU-1268020|reactome:R-MMU-163210|reactome:R-MMU-8949613|interpro:IPR020003|ensembl:ENSMUSG00000025393(gene)|ensembl:ENSMUST00000026459(transcript)|go:"GO:0000275"("mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)")|go:"GO:0001525"(angiogenesis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006933"(negative regulation of cell adhesion involved in substrate-bound cell migration)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0030228"(lipoprotein particle receptor activity)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0043209"(myelin sheath)|go:"GO:0043531"(ADP binding)|go:"GO:0043532"(angiostatin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045259"(proton-transporting ATP synthase complex)|go:"GO:0045261"("proton-transporting ATP synthase complex, catalytic core F(1)")|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR000194(ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004100(ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal)|interpro:IPR005722(ATPase, F1 complex, beta subunit)|go:"GO:0005524"(ATP binding)|refseq:NP_058054.2	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:ihjn7GQ1ZSBfGcfwEAYSiCIuq+410090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:O35685	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-911192|ensembl:ENSMUSP00000030665|uniprotkb:Q3UJS7	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:nudc_mouse(display_long)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym)|uniprotkb:Silica-induced gene 92 protein(gene name synonym)|uniprotkb:Nudc(gene name)|psi-mi:Nudc(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	ensembl:ENSMUSG00000028851(gene)|ensembl:ENSMUST00000030665(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007097"(nuclear migration)|go:"GO:0030496"(midbody)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:O35685|rcsb pdb:1WFI|rcsb pdb:2CR0|reactome:R-MMU-141444|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-5663220|reactome:R-MMU-68877|reactome:R-MMU-9648025|reactome:R-MMU-9696270|refseq:NP_035078.1	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:eTyJnGWQOOMlsBv/LGFjOPsg1Ro10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q80UU9	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634859|ensembl:ENSMUSP00000056643	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:pgrc2_mouse(display_long)|uniprotkb:Pgrmc2(gene name)|psi-mi:Pgrmc2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_081834.1|ensembl:ENSMUSG00000049940(gene)|ensembl:ENSMUST00000058578(transcript)|go:"GO:0005496"(steroid binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0012505"(endomembrane system)|go:"GO:0015232"(heme transmembrane transporter activity)|go:"GO:0015886"(heme transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020037"(heme binding)|go:"GO:0060612"(adipose tissue development)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|reactome:R-MMU-8980692|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013408|reactome:R-MMU-9013423	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:KIn48KpS0Z3E1uqRAIbFZVL/nnc10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q5SX40	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634619|uniprotkb:Q32P18|ensembl:ENSMUSP00000018637|ensembl:ENSMUSP00000075147|ensembl:ENSMUSP00000117569	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:myh1_mouse(display_long)|uniprotkb:Myh1(gene name)|psi-mi:Myh1(display_short)|uniprotkb:Myosin heavy chain 1(gene name synonym)|uniprotkb:Myosin heavy chain 2x(gene name synonym)|uniprotkb:Myosin heavy chain, skeletal muscle, adult 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_109604.1|refseq:XP_017169807.1|ensembl:ENSMUSG00000056328(gene)|ensembl:ENSMUST00000018637(transcript)|ensembl:ENSMUST00000075734(transcript)|ensembl:ENSMUST00000124516(transcript)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005859"(muscle myosin complex)|go:"GO:0006936"(muscle contraction)|go:"GO:0014704"(intercalated disc)|go:"GO:0031672"(A band)|go:"GO:0032982"(myosin filament)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0051015"(actin filament binding)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR002928(Myosin tail)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR014751(DNA double-strand break repair and VJ recombination XRCC4, C-terminal)|interpro:IPR027417|interpro:IPR036961|mint:Q5SX40	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:LR8EokV3LoiQJ3ykzeelwyDCO6Q10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P13707	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634419|uniprotkb:Q3UVM3|uniprotkb:Q5DTS5|ensembl:ENSMUSP00000023760	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:gpda_mouse(display_long)|uniprotkb:Gpd1(gene name)|psi-mi:Gpd1(display_short)|uniprotkb:Gdc-1(gene name synonym)|uniprotkb:Gdc1(gene name synonym)|uniprotkb:Kiaa4010(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_034401.1|ensembl:ENSMUSG00000023019(gene)|ensembl:ENSMUST00000023760(transcript)|go:"GO:0004367"(glycerol-3-phosphate dehydrogenase [NAD+] activity)|go:"GO:0004368"("glycerol-3-phosphate dehydrogenase (quinone) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006072"(glycerol-3-phosphate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006116"(NADH oxidation)|go:"GO:0006127"(glycerophosphate shuttle)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0009331"(glycerol-3-phosphate dehydrogenase complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0046168"(glycerol-3-phosphate catabolic process)|go:"GO:0046486"(glycerolipid metabolic process)|go:"GO:0051287"(NAD binding)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR006109(NAD-dependent glycerol-3-phosphate dehydrogenase, C-terminal)|interpro:IPR006168(NAD-dependent glycerol-3-phosphate dehydrogenase)|interpro:IPR008927(6-phosphogluconate dehydrogenase, C-terminal-like)|interpro:IPR011128(NAD-dependent glycerol-3-phosphate dehydrogenase, N-terminal)|interpro:IPR013328(Dehydrogenase, multihelical)|interpro:IPR017751(NAD-dependent glycerol-3-phosphate dehydrogenase, eukaryotic)|interpro:IPR036291|mint:P13707|reactome:R-MMU-1483166	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:qAqO6vxFpOQeXUPIpNI5A2fDBN410090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q9CZ13	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-773751|uniprotkb:Q9CWL6|uniprotkb:Q3TV75|ensembl:ENSMUSP00000026743	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:qcr1_mouse(display_long)|uniprotkb:Ubiquinol-cytochrome-c reductase complex core protein 1(gene name synonym)|uniprotkb:Complex III subunit 1(gene name synonym)|uniprotkb:Uqcrc1(gene name)|psi-mi:Uqcrc1(display_short)|uniprotkb:Core protein I(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_079683.2|ensembl:ENSMUSG00000025651(gene)|ensembl:ENSMUST00000026743(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0006122"(mitochondrial electron transport, ubiquinol to cytochrome c)|go:"GO:0014823"(response to activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034551"(mitochondrial respiratory chain complex III assembly)|go:"GO:0043209"(myelin sheath)|go:"GO:0043279"(response to alkaloid)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR007863(Peptidase M16, C-terminal)|interpro:IPR011249(Metalloenzyme, LuxS/M16 peptidase-like, metal-binding)|interpro:IPR011765(Peptidase M16, N-terminal)|mint:Q9CZ13|reactome:R-MMU-611105	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:oPlGhzsHLustrgdY4P+DdyJePbA10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P06151	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-444940|ensembl:ENSMUSP00000036386|ensembl:ENSMUSP00000103267	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:ldha_mouse(display_long)|uniprotkb:LDH muscle subunit(gene name synonym)|uniprotkb:Ldha(gene name)|psi-mi:Ldha(display_short)|uniprotkb:Ldh-1(gene name synonym)|uniprotkb:Ldh1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_034829.1|ensembl:ENSMUSG00000063229(gene)|ensembl:ENSMUST00000005051(transcript)|ensembl:ENSMUST00000048209(transcript)|go:"GO:0004457"(lactate dehydrogenase activity)|go:"GO:0004459"(L-lactate dehydrogenase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0019244"(lactate biosynthetic process from pyruvate)|go:"GO:0019661"(glucose catabolic process to lactate via pyruvate)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0035686"(sperm fibrous sheath)|go:"GO:0042802"(identical protein binding)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR011304(L-lactate dehydrogenase)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR018177|interpro:IPR022383|interpro:IPR036291|mint:P06151|reactome:R-MMU-70268	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:IErFuOIWq53/XyIxWgUyVi76VnM10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P20029	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-772325|uniprotkb:Q3UFF2|uniprotkb:O35642|uniprotkb:Q61630|intact:EBI-4280750|ensembl:ENSMUSP00000028222|ensembl:ENSMUSP00000097747	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:bip_mouse(display_long)|uniprotkb:Immunoglobulin heavy chain-binding protein(gene name synonym)|uniprotkb:Hspa5(gene name)|psi-mi:Hspa5(display_short)|uniprotkb:Grp78(gene name synonym)|uniprotkb:78 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Binding-immunoglobulin protein(gene name synonym)|uniprotkb:Heat shock protein 70 family protein 5(gene name synonym)|uniprotkb:Heat shock protein family A member 5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_001156906.1|refseq:NP_071705.3|dip:DIP-32341N|ensembl:ENSMUSG00000026864(gene)|ensembl:ENSMUST00000028222(transcript)|ensembl:ENSMUST00000100171(transcript)|go:"GO:0001554"(luteolysis)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006983"(ER overload response)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021589"(cerebellum structural organization)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035437"(maintenance of protein localization in endoplasmic reticulum)|go:"GO:0035690"|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0042026"(protein refolding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042220"(response to cocaine)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0097501"(stress response to metal ion)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901998"(toxin transport)|go:"GO:1903895"(negative regulation of IRE1-mediated unfolded protein response)|go:"GO:1904313"(response to methamphetamine hydrochloride)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042050|interpro:IPR043129|mint:P20029|reactome:R-MMU-3371453|reactome:R-MMU-983170	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:AyJwwnH8IAQqF/cbTn336A79MOY10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P08553	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-445188|uniprotkb:A2VCT5|uniprotkb:Q0VDM8|uniprotkb:Q3HRJ6|uniprotkb:Q3TNS4|uniprotkb:Q3TPK2|uniprotkb:Q61961|uniprotkb:Q8BQ20	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:nfm_mouse(display_long)|uniprotkb:Neurofilament triplet M protein(gene name synonym)|uniprotkb:160 kDa neurofilament protein(gene name synonym)|uniprotkb:Neurofilament 3(gene name synonym)|uniprotkb:Nefm(gene name)|psi-mi:Nefm(display_short)|uniprotkb:Nef3(gene name synonym)|uniprotkb:Nfm(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_032717.2|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR002957(Keratin, type I)|interpro:IPR039008|interpro:IPR027697|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0005883"(neurofilament)|go:"GO:0008088"(axo-dendritic transport)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015643"(toxic substance binding)|go:"GO:0030424"(axon)|go:"GO:0031133"(regulation of axon diameter)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0033693"(neurofilament bundle assembly)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0043209"(myelin sheath)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045105"(intermediate filament polymerization or depolymerization)|go:"GO:0045110"(intermediate filament bundle assembly)|go:"GO:0060052"(neurofilament cytoskeleton organization)|go:"GO:0099160"(postsynaptic intermediate filament cytoskeleton)|go:"GO:0099182"(presynaptic intermediate filament cytoskeleton)|mint:P08553	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:2HBUZIEhbbrfamAhbq7gyuRUaTk10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P17156	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-494667|intact:EBI-2942789|uniprotkb:Q99KD7|ensembl:ENSMUSP00000079306|ensembl:ENSMUSP00000151408	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:hsp72_mouse(display_long)|uniprotkb:Hspa2(gene name)|psi-mi:Hspa2(display_short)|uniprotkb:Hcp70.2(gene name synonym)|uniprotkb:Hsp70-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_001002012.1|refseq:NP_032327.2|refseq:XP_006515547.1|dip:DIP-42071N|ensembl:ENSMUSG00000059970(gene)|ensembl:ENSMUST00000080449(transcript)|ensembl:ENSMUST00000219555(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|reactome:R-MMU-3371568|go:"GO:0005739"(mitochondrion)|go:"GO:0009408"(response to heat)|go:"GO:0009409"(response to cold)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007141"(male meiosis I)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0036128"(CatSper complex)|go:"GO:0042026"(protein refolding)|go:"GO:0043209"(myelin sheath)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0048156"(tau protein binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051861"(glycolipid binding)|go:"GO:0070194"(synaptonemal complex disassembly)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0007283"(spermatogenesis)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901896"(positive regulation of ATPase-coupled calcium transmembrane transporter activity)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|go:"GO:0007286"(spermatid development)|interpro:IPR029048|interpro:IPR043129|reactome:R-MMU-3371453|reactome:R-MMU-3371497	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:wpWle7NX8ixNNq35mZt14enug4E10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P08226	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634131|ensembl:ENSMUSP00000003066|ensembl:ENSMUSP00000133302|ensembl:ENSMUSP00000133371|ensembl:ENSMUSP00000134160	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:apoe_mouse(display_long)|uniprotkb:Apoe(gene name)|psi-mi:Apoe(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_001292748.1|refseq:NP_001292772.1|refseq:NP_001292773.1|refseq:NP_033826.2|ensembl:ENSMUSG00000002985(gene)|ensembl:ENSMUST00000003066(transcript)|ensembl:ENSMUST00000173739(transcript)|ensembl:ENSMUST00000174064(transcript)|ensembl:ENSMUST00000174355(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002021"(response to dietary excess)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006707"(cholesterol catabolic process)|go:"GO:0006869"(lipid transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007568"(aging)|go:"GO:0007616"(long-term memory)|go:"GO:0008201"(heparin binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009986"(cell surface)|go:"GO:0010467"(gene expression)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010544"(negative regulation of platelet activation)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010877"(lipid transport involved in lipid storage)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015909"(long-chain fatty acid transport)|go:"GO:0016209"(antioxidant activity)|go:"GO:0017038"(protein import)|go:"GO:0019068"(virion assembly)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0030425"(dendrite)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031175"(neuron projection development)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0032269"(negative regulation of cellular protein metabolic process)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0032805"(positive regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034363"(intermediate-density lipoprotein particle)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0034365"(discoidal high-density lipoprotein particle)|go:"GO:0034372"(very-low-density lipoprotein particle remodeling)|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0034375"(high-density lipoprotein particle remodeling)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034382"(chylomicron remnant clearance)|go:"GO:0034384"(high-density lipoprotein particle clearance)|go:"GO:0034447"(very-low-density lipoprotein particle clearance)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042158"(lipoprotein biosynthetic process)|go:"GO:0042159"(lipoprotein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0042627"(chylomicron)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0045541"(negative regulation of cholesterol biosynthetic process)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046848"(hydroxyapatite binding)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0046911"(metal chelating activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051055"(negative regulation of lipid biosynthetic process)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0051651"(maintenance of location in cell)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060228"(phosphatidylcholine-sterol O-acyltransferase activator activity)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0061771"(response to caloric restriction)|go:"GO:0070326"(very-low-density lipoprotein particle receptor binding)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0071830"(triglyceride-rich lipoprotein particle clearance)|go:"GO:0071831"(intermediate-density lipoprotein particle clearance)|go:"GO:0072359"(circulatory system development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090181"(regulation of cholesterol metabolic process)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0090209"(negative regulation of triglyceride metabolic process)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:0097006"(regulation of plasma lipoprotein particle levels)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:1900221"(regulation of amyloid-beta clearance)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901627"(negative regulation of postsynaptic membrane organization)|go:"GO:1901631"(positive regulation of presynaptic membrane organization)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902947"(regulation of tau-protein kinase activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1902991"(regulation of amyloid precursor protein catabolic process)|go:"GO:1902995"(positive regulation of phospholipid efflux)|go:"GO:1902998"(positive regulation of neurofibrillary tangle assembly)|go:"GO:1902999"(negative regulation of phospholipid efflux)|go:"GO:1903001"(negative regulation of lipid transport across blood-brain barrier)|go:"GO:1903002"(positive regulation of lipid transport across blood-brain barrier)|go:"GO:1905855"(positive regulation of heparan sulfate binding)|go:"GO:1905860"(positive regulation of heparan sulfate proteoglycan binding)|go:"GO:1905890"(regulation of cellular response to very-low-density lipoprotein particle stimulus)|go:"GO:1905906"(regulation of amyloid fibril formation)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990777"(lipoprotein particle)|go:"GO:2000822"(regulation of behavioral fear response)|interpro:IPR000074(Apolipoprotein A1/A4/E)|mint:P08226|rcsb pdb:1YA9|reactome:R-MMU-3000480|reactome:R-MMU-381426|reactome:R-MMU-8957275|reactome:R-MMU-8963888|reactome:R-MMU-8963901|reactome:R-MMU-8964026|reactome:R-MMU-8964058|reactome:R-MMU-975634	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:fJDvqSxzmdZmV8t1M4yp9jw1jvU10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q01853	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-80597|ensembl:ENSMUSP00000030164|uniprotkb:Q3TFH9|uniprotkb:Q3TIM2|uniprotkb:Q3TXN9|uniprotkb:Q6PI18|uniprotkb:Q8BSR6|uniprotkb:Q8CEG4	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:tera_mouse(display_long)|uniprotkb:Vcp(gene name)|psi-mi:Vcp(display_short)|uniprotkb:"15S Mg(2+)-ATPase p97 subunit"(gene name synonym)|uniprotkb:Valosin-containing protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0061857"(endoplasmic reticulum stress-induced pre-emptive quality control)|go:"GO:0070842"(aggresome assembly)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072389"(flavin adenine dinucleotide catabolic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043531"(ADP binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0106300"(protein-DNA covalent cross-linking repair)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903006"(positive regulation of protein K63-linked deubiquitination)|go:"GO:1903007"(positive regulation of Lys63-specific deubiquitinase activity)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1903843"(cellular response to arsenite ion)|go:"GO:1903862"(positive regulation of oxidative phosphorylation)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:1904949"(ATPase complex)|go:"GO:1905634"(regulation of protein localization to chromatin)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990730"(VCP-NSFL1C complex)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR005938(AAA ATPase, CDC48)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR029067|interpro:IPR041569|mint:Q01853|rcsb pdb:1E32|rcsb pdb:1R7R|rcsb pdb:1S3S|rcsb pdb:2PJH|rcsb pdb:3CF0|rcsb pdb:3CF1|rcsb pdb:3CF2|rcsb pdb:3CF3|reactome:R-MMU-110320|reactome:R-MMU-3371511|reactome:R-MMU-382556|reactome:R-MMU-532668|reactome:R-MMU-5358346|reactome:R-MMU-5689877|reactome:R-MMU-5689896|reactome:R-MMU-6798695|reactome:R-MMU-8876725|reactome:R-MMU-9013407|ensembl:ENSMUSG00000028452(gene)|ensembl:ENSMUST00000030164(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006914"(autophagy)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008289"(lipid binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0016236"(macroautophagy)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019079"(viral genome replication)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032510"(endosome to lysosome transport via multivesicular body sorting pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035617"(stress granule disassembly)|go:"GO:0035800"(deubiquitinase activator activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|go:"GO:0036503"(ERAD pathway)|go:"GO:0019904"(protein domain specific binding)|refseq:NP_033529.3|dip:DIP-29796N	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:HrjDhdsDcgaf8HEbqqMjUqxPaEs10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q01339	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634175|ensembl:ENSMUSP00000000049	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:apoh_mouse(display_long)|uniprotkb:Apoh(gene name)|psi-mi:Apoh(display_short)|uniprotkb:B2gp1(gene name synonym)|uniprotkb:Beta-2-glycoprotein I(gene name synonym)|uniprotkb:Apolipoprotein H(gene name synonym)|uniprotkb:Activated protein C-binding protein(gene name synonym)|uniprotkb:APC inhibitor(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_038503.4|ensembl:ENSMUSG00000000049(gene)|ensembl:ENSMUST00000000049(transcript)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0007596"(blood coagulation)|go:"GO:0007597"(blood coagulation, intrinsic pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009986"(cell surface)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010898"(positive regulation of triglyceride catabolic process)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031639"(plasminogen activation)|go:"GO:0033033"(negative regulation of myeloid cell apoptotic process)|go:"GO:0034197"(triglyceride transport)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0042627"(chylomicron)|go:"GO:0042802"(identical protein binding)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0051917"(regulation of fibrinolysis)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0060230"(lipoprotein lipase activator activity)|go:"GO:0060268"(negative regulation of respiratory burst)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR015104(Beta-2-glycoprotein-1 fifth domain)|interpro:IPR035976|reactome:R-MMU-114608	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:fZm3KpF4b3PB7ICTq3jBYHkv/Xs10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P05064	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-494220|ensembl:ENSMUSP00000032934|ensembl:ENSMUSP00000101955	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:aldoa_mouse(display_long)|uniprotkb:Muscle-type aldolase(gene name synonym)|uniprotkb:Aldolase 1(gene name synonym)|uniprotkb:Aldoa(gene name)|psi-mi:Aldoa(display_short)|uniprotkb:Aldo1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:XP_006507273.1|refseq:XP_006507274.1|refseq:NP_001170779.1|refseq:NP_031464.1|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019242"(methylglyoxal biosynthetic process)|go:"GO:0030018"(Z disc)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0031430"(M band)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035686"(sperm fibrous sheath)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0061615"(glycolytic process through fructose-6-phosphate)|go:"GO:0061827"(sperm head)|go:"GO:0005886"(plasma membrane)|go:"GO:0070061"(fructose binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000741(Fructose-bisphosphate aldolase, class-I)|interpro:IPR013785(Aldolase-type TIM barrel)|ensembl:ENSMUSG00000030695(gene)|ensembl:ENSMUST00000032934(transcript)|ensembl:ENSMUST00000106348(transcript)|go:"GO:0000792"(heterochromatin)|go:"GO:0002020"(protease binding)|go:"GO:0004332"(fructose-bisphosphate aldolase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|mint:P05064|reactome:R-MMU-114608|reactome:R-MMU-6798695|reactome:R-MMU-70171|reactome:R-MMU-70263|interpro:IPR029768	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:m116/AX8vWkh1JCGOnEZv9ZOU9010090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P48036	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1184119|uniprotkb:Q3U5Q1|uniprotkb:Q3U5X4|uniprotkb:Q3U8K1|uniprotkb:Q3UGV0|uniprotkb:Q99LA1|ensembl:ENSMUSP00000029266	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:anxa5_mouse(display_long)|uniprotkb:Anxa5(gene name)|psi-mi:Anxa5(display_short)|uniprotkb:Anx5(gene name synonym)|uniprotkb:Annexin-5(gene name synonym)|uniprotkb:Annexin V(gene name synonym)|uniprotkb:Lipocortin V(gene name synonym)|uniprotkb:Endonexin II(gene name synonym)|uniprotkb:Calphobindin I(gene name synonym)|uniprotkb:Placental anticoagulant protein I(gene name synonym)|uniprotkb:Placental anticoagulant protein 4(gene name synonym)|uniprotkb:Thromboplastin inhibitor(gene name synonym)|uniprotkb:Vascular anticoagulant-alpha(gene name synonym)|uniprotkb:Anchorin CII(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_033803.1|go:"GO:1901317"(regulation of flagellated sperm motility)|go:"GO:1902721"(negative regulation of prolactin secretion)|interpro:IPR001464(Annexin)|interpro:IPR002392(Annexin, type V)|interpro:IPR018252|interpro:IPR018502|interpro:IPR037104|mint:P48036|reactome:R-MMU-114608|go:"GO:0097211"(cellular response to gonadotropin-releasing hormone)|ensembl:ENSMUSG00000027712(gene)|ensembl:ENSMUST00000029266(transcript)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007596"(blood coagulation)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010033"(response to organic substance)|go:"GO:0014704"(intercalated disc)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0030018"(Z disc)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0030425"(dendrite)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0043679"(axon terminus)|go:"GO:0051592"(response to calcium ion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0072563"(endothelial microparticle)	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:CJEThujZVYsg5/wpN8fAMdpY38U10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P70296	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634763|uniprotkb:Q9D8G9|uniprotkb:Q9JJ58|ensembl:ENSMUSP00000048425	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:pebp1_mouse(display_long)|uniprotkb:Pebp1(gene name)|psi-mi:Pebp1(display_short)|uniprotkb:Pbp(gene name synonym)|uniprotkb:Pebp(gene name synonym)|uniprotkb:HCNPpp(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_061346.2|ensembl:ENSMUSG00000032959(gene)|ensembl:ENSMUST00000036951(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001505"(regulation of neurotransmitter levels)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008289"(lipid binding)|go:"GO:0009986"(cell surface)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0033612"(receptor serine/threonine kinase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043679"(axon terminus)|go:"GO:0043950"(positive regulation of cAMP-mediated signaling)|go:"GO:0045177"(apical part of cell)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0048240"(sperm capacitation)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0060409"(positive regulation of acetylcholine metabolic process)|interpro:IPR001858(Phosphatidylethanolamine-binding, conserved site)|interpro:IPR008914(Phosphatidylethanolamine-binding protein PEBP)|interpro:IPR035810|interpro:IPR036610|mint:P70296|rcsb pdb:6ENS|reactome:R-MMU-5674135|reactome:R-MMU-5675221	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:vhkkuZ49z3Vuw7O4bdlc/5WxlKk10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P60122	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634999|uniprotkb:O35753|ensembl:ENSMUSP00000032165	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:ruvb1_mouse(display_long)|uniprotkb:Ruvbl1(gene name)|psi-mi:Ruvbl1(display_short)|uniprotkb:Tip49(gene name synonym)|uniprotkb:Tip49a(gene name synonym)|uniprotkb:49 kDa TATA box-binding protein-interacting protein(gene name synonym)|uniprotkb:TIP49a(gene name synonym)|uniprotkb:Pontin 52(gene name synonym)|uniprotkb:DNA helicase p50(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_062659.1|ensembl:ENSMUSG00000030079(gene)|ensembl:ENSMUST00000032165(transcript)|go:"GO:0000492"(box C/D snoRNP assembly)|go:"GO:0000812"(Swr1 complex)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0010756"(positive regulation of plasminogen activation)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016573"(histone acetylation)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0031011"(Ino80 complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0043531"(ADP binding)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043968"(histone H2A acetylation)|go:"GO:0051117"(ATPase binding)|go:"GO:0051301"(cell division)|go:"GO:0071339"(MLL1 complex)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097255"(R2TP complex)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000269"(regulation of fibroblast apoptotic process)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR010339(TIP49, C-terminal)|interpro:IPR027238|interpro:IPR027417|interpro:IPR037938|interpro:IPR041048|mint:P60122|reactome:R-MMU-5689603|reactome:R-MMU-5689880|reactome:R-MMU-5696394|reactome:R-MMU-606279	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:fZiQ7AurvKII0LYc+haBswAXfZ410090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P99024	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-350896|uniprotkb:P05218|uniprotkb:Q3TFB6|uniprotkb:Q3THH9|uniprotkb:Q3TIL1|uniprotkb:Q3UAV4|uniprotkb:Q3UF52|uniprotkb:Q8WUC1|uniprotkb:Q9CY33|uniprotkb:B1B178|ensembl:ENSMUSP00000001566	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:tbb5_mouse(display_long)|uniprotkb:Tubb5(gene name)|psi-mi:Tubb5(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_035785.1|interpro:IPR023123|interpro:IPR036525|interpro:IPR018316|interpro:IPR037103|mint:P99024|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-6798695|reactome:R-MMU-8854518|ensembl:ENSMUSG00000001525(gene)|ensembl:ENSMUST00000001566(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007017"(microtubule-based process)|go:"GO:0009987"(cellular process)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045298"(tubulin complex)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051225"(spindle assembly)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:B6pmb1dvCroZXGd/1Zazi+s72GA10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P40142	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-494230|uniprotkb:Q3U7Y1|uniprotkb:Q3UK62|uniprotkb:Q545A1|uniprotkb:Q9ESA0|ensembl:ENSMUSP00000022529	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:tkt_mouse(display_long)|uniprotkb:P68(gene name synonym)|uniprotkb:Tkt(gene name)|psi-mi:Tkt(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_033414.1|ensembl:ENSMUSG00000021957(gene)|ensembl:ENSMUST00000022529(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004802"(transketolase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005777"(peroxisome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006098"(pentose-phosphate shunt)|go:"GO:0009052"(pentose-phosphate shunt, non-oxidative branch)|go:"GO:0016604"(nuclear body)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030976"(thiamine pyrophosphate binding)|go:"GO:0040008"(regulation of growth)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046166"(glyceraldehyde-3-phosphate biosynthetic process)|go:"GO:0046390"(ribose phosphate biosynthetic process)|go:"GO:0048029"(monosaccharide binding)|interpro:IPR005474(Transketolase, N-terminal)|interpro:IPR005475(Transketolase, central region)|interpro:IPR009014(Transketolase, C-terminal/Pyruvate-ferredoxin oxidoreductase, domain II)|interpro:IPR020826|interpro:IPR029061|interpro:IPR033248|mint:P40142|reactome:R-MMU-163754|reactome:R-MMU-71336	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:h2YT3KKVrgDmPcSbJmtevBv1CAI10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P00920	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-494455|uniprotkb:Q6LDQ7|uniprotkb:Q7TPE1|uniprotkb:Q9DCT3|uniprotkb:Q9DCY9|ensembl:ENSMUSP00000029078	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:cah2_mouse(display_long)|uniprotkb:Carbonic anhydrase II(gene name synonym)|uniprotkb:Carbonate dehydratase II(gene name synonym)|uniprotkb:Ca2(gene name)|psi-mi:Ca2(display_short)|uniprotkb:Car2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:XP_006530113.1|refseq:NP_033931.4|ensembl:ENSMUSG00000027562(gene)|ensembl:ENSMUST00000029078(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0004064"(arylesterase activity)|go:"GO:0004089"(carbonate dehydratase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0006885"(regulation of pH)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009268"(response to pH)|go:"GO:0010043"(response to zinc ion)|go:"GO:0015670"(carbon dioxide transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030424"(axon)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032849"(positive regulation of cellular pH reduction)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0043209"(myelin sheath)|go:"GO:0043627"(response to estrogen)|go:"GO:0044070"(regulation of anion transport)|go:"GO:0045177"(apical part of cell)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0046903"(secretion)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0016836"(hydro-lyase activity)|go:"GO:2001150"(positive regulation of dipeptide transmembrane transport)|go:"GO:2001225"(regulation of chloride transport)|interpro:IPR001148(Carbonic anhydrase, eukaryotic)|interpro:IPR018338|interpro:IPR023561|interpro:IPR036398|mint:P00920|reactome:R-MMU-1237044|reactome:R-MMU-1247673|reactome:R-MMU-1475029	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:yKNkYmfMPQjDFpQ/yzDiX+R9tJI10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P11087	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634830|uniprotkb:Q53WT0|uniprotkb:Q60635|uniprotkb:Q61367|uniprotkb:Q61427|uniprotkb:Q63919|uniprotkb:Q6PCL3|uniprotkb:Q810J9|ensembl:ENSMUSP00000001547	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:co1a1_mouse(display_long)|uniprotkb:Col1a1(gene name)|psi-mi:Col1a1(display_short)|uniprotkb:Cola1(gene name synonym)|uniprotkb:Alpha-1 type I collagen(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_031768.2|ensembl:ENSMUSG00000001506(gene)|ensembl:ENSMUST00000001547(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001957"(intramembranous ossification)|go:"GO:0001958"(endochondral ossification)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005584"(collagen type I trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0015031"(protein transport)|go:"GO:0030141"(secretory granule)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032355"(response to estradiol)|go:"GO:0032964"(collagen biosynthetic process)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034505"(tooth mineralization)|go:"GO:0038063"(collagen-activated tyrosine kinase receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043588"(skin development)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0044691"(tooth eruption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048407"(platelet-derived growth factor binding)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0051591"(response to cAMP)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060346"(bone trabecula formation)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071306"(cellular response to vitamin E)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902618"(cellular response to fluoride)|interpro:IPR000885(Fibrillar collagen, C-terminal)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR008160(Collagen triple helix repeat)|mint:P11087|reactome:R-MMU-114604|reactome:R-MMU-1442490|reactome:R-MMU-1474244|reactome:R-MMU-1650814|reactome:R-MMU-198933|reactome:R-MMU-2022090|reactome:R-MMU-202733|reactome:R-MMU-216083|reactome:R-MMU-2214320|reactome:R-MMU-2243919|reactome:R-MMU-3000171|reactome:R-MMU-3000178|reactome:R-MMU-430116|reactome:R-MMU-75892|reactome:R-MMU-76009|reactome:R-MMU-8874081|reactome:R-MMU-8948216|go:"GO:0002020"(protease binding)	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:mZrc8e1VDJc4u6y4zXOj0glFj9410090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q9CQ65	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634581|uniprotkb:Q3TJS4|ensembl:ENSMUSP00000061092	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:mtap_mouse(display_long)|uniprotkb:Mtap(gene name)|psi-mi:Mtap(display_short)|uniprotkb:5'-methylthioadenosine phosphorylase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_077753.1|ensembl:ENSMUSG00000062937(gene)|ensembl:ENSMUST00000058030(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006166"(purine ribonucleoside salvage)|go:"GO:0017061"(S-methyl-5-thioadenosine phosphorylase activity)|go:"GO:0019509"(L-methionine salvage from methylthioadenosine)|go:"GO:0032259"(methylation)|interpro:IPR000845(Nucleoside phosphorylase)|interpro:IPR010044(Methylthioadenosine phosphorylase)|interpro:IPR018099|interpro:IPR035994|mint:Q9CQ65|reactome:R-MMU-1237112	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:YeDV+ssejN30TWoPTdoryhhEWcY10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P23927	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-299046|ensembl:ENSMUSP00000034562|ensembl:ENSMUSP00000149759|ensembl:ENSMUSP00000149803|ensembl:ENSMUSP00000150669|uniprotkb:Q64325	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:cryab_mouse(display_long)|uniprotkb:Cryab(gene name)|psi-mi:Cryab(display_short)|uniprotkb:Crya2(gene name synonym)|uniprotkb:"Alpha(B)-crystallin"(gene name synonym)|uniprotkb:P23(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	ensembl:ENSMUSG00000032060(gene)|ensembl:ENSMUST00000034562(transcript)|ensembl:ENSMUST00000214962(transcript)|ensembl:ENSMUST00000216755(transcript)|ensembl:ENSMUST00000217475(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0007021"(tubulin complex assembly)|go:"GO:0007517"(muscle organ development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009986"(cell surface)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010941"(regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030018"(Z disc)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0031109"(microtubule polymerization or depolymerization)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031430"(M band)|go:"GO:0031674"(I band)|go:"GO:0032355"(response to estradiol)|go:"GO:0032387"(negative regulation of intracellular transport)|go:"GO:0032432"(actin filament bundle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043209"(myelin sheath)|go:"GO:0043292"(contractile fiber)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0060561"(apoptotic process involved in morphogenesis)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097512"(cardiac myofibril)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR003090(Alpha-crystallin, N-terminal)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037882|mint:P23927|reactome:R-MMU-3371571|refseq:XP_006510033.1|refseq:NP_034094.1|refseq:NP_001276711.1|refseq:NP_001276713.1|refseq:NP_001276714.1|dip:DIP-31060N	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:LOp5smbeRceV8/P+Eaoh7p+24Vw10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:Q99JY9	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-773994|uniprotkb:Q9DC56|ensembl:ENSMUSP00000027579|ensembl:ENSMUSP00000137503	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:arp3_mouse(display_long)|uniprotkb:Actin-like protein 3(gene name synonym)|uniprotkb:Actr3(gene name)|psi-mi:Actr3(display_short)|uniprotkb:Arp3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2024267|imex:IM-9475-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_001192314.1|refseq:NP_001192315.1|refseq:NP_076224.1|ensembl:ENSMUSG00000026341(gene)|ensembl:ENSMUST00000027579(transcript)|ensembl:ENSMUST00000178474(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0016344"(meiotic chromosome movement towards spindle pole)|go:"GO:0030027"(lamellipodium)|go:"GO:0030056"(hemidesmosome)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031252"(cell leading edge)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0033206"(meiotic cytokinesis)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0043519"(regulation of myosin II filament organization)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0051015"(actin filament binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051653"(spindle localization)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060271"(cilium assembly)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061825"(podosome core)|go:"GO:0061828"(apical tubulobulbar complex)|go:"GO:0061830"(concave side of sperm head)|go:"GO:0061831"(apical ectoplasmic specialization)|go:"GO:0061832"(basal ectoplasmic specialization)|go:"GO:0061851"(leading edge of lamellipodium)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1904171"(negative regulation of bleb assembly)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR004000(Actin/actin-like)|interpro:IPR015623(Actin-related protein 3)|interpro:IPR020902|interpro:IPR043129|mint:Q99JY9|rcsb pdb:7AQK|reactome:R-MMU-2029482|reactome:R-MMU-3928662|reactome:R-MMU-5663213|reactome:R-MMU-8856828	go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)	-	-	figure legend:Fig. 1, Supp. Fig. 1, Table 4|caution:[EBI-1635058] The protein has been merged with EBI-772469 so the duplicated interactor has been deleted from this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:FBCctn7WChHon0MhVlJUO4ctinE10090	intact-crc:2A3857E69C963EA0|rigid:Bd0lA8FSY0W/WG2k7wbEqSTvGYE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08460	uniprotkb:P63260	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-351301|uniprotkb:P02571|uniprotkb:P14104|uniprotkb:P99022|ensembl:ENSMUSP00000071486|ensembl:ENSMUSP00000101822	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:actg_mouse(display_long)|uniprotkb:Actg1(gene name)|psi-mi:Actg1(display_short)|uniprotkb:Actg(gene name synonym)|uniprotkb:Gamma-actin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2107722|imex:IM-9475-29	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_033739.1|reactome:R-MMU-190873|reactome:R-MMU-196025|reactome:R-MMU-2029482|reactome:R-MMU-3928662|reactome:R-MMU-418990|reactome:R-MMU-437239|reactome:R-MMU-4420097|reactome:R-MMU-445095|reactome:R-MMU-446353|reactome:R-MMU-5626467|reactome:R-MMU-5663213|reactome:R-MMU-5663220|reactome:R-MMU-5674135|reactome:R-MMU-8856828|reactome:R-MMU-9013418|ensembl:ENSMUSG00000062825(gene)|ensembl:ENSMUST00000071555(transcript)|ensembl:ENSMUST00000106215(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005522"(profilin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030016"(myofibril)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0042802"(identical protein binding)|go:"GO:0043034"(costamere)|go:"GO:0043209"(myelin sheath)|go:"GO:0043296"(apical junction complex)|go:"GO:0044305"(calyx of Held)|go:"GO:0045177"(apical part of cell)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097433"(dense body)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0099143"(presynaptic actin cytoskeleton)|go:"GO:0120192"(tight junction assembly)|go:"GO:0120220"(basal body patch)|go:"GO:0150111"(regulation of transepithelial transport)|go:"GO:1902396"(protein localization to bicellular tight junction)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|interpro:IPR043129|reactome:R-MMU-114608	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:B2OOsE06lTfo90H3g8tlmUJQ7cY10090	intact-crc:100F7AD31FB52691|rigid:xBGBDpeR7uOdxEoDNp2EYlHg/W8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P48036	uniprotkb:Q08460	intact:EBI-1184119|uniprotkb:Q3U5Q1|uniprotkb:Q3U5X4|uniprotkb:Q3U8K1|uniprotkb:Q3UGV0|uniprotkb:Q99LA1|ensembl:ENSMUSP00000029266	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	psi-mi:anxa5_mouse(display_long)|uniprotkb:Anxa5(gene name)|psi-mi:Anxa5(display_short)|uniprotkb:Anx5(gene name synonym)|uniprotkb:Annexin-5(gene name synonym)|uniprotkb:Annexin V(gene name synonym)|uniprotkb:Lipocortin V(gene name synonym)|uniprotkb:Endonexin II(gene name synonym)|uniprotkb:Calphobindin I(gene name synonym)|uniprotkb:Placental anticoagulant protein I(gene name synonym)|uniprotkb:Placental anticoagulant protein 4(gene name synonym)|uniprotkb:Thromboplastin inhibitor(gene name synonym)|uniprotkb:Vascular anticoagulant-alpha(gene name synonym)|uniprotkb:Anchorin CII(gene name synonym)	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2107726|imex:IM-9475-26	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033803.1|go:"GO:1901317"(regulation of flagellated sperm motility)|go:"GO:1902721"(negative regulation of prolactin secretion)|interpro:IPR001464(Annexin)|interpro:IPR002392(Annexin, type V)|interpro:IPR018252|interpro:IPR018502|interpro:IPR037104|mint:P48036|reactome:R-MMU-114608|go:"GO:0097211"(cellular response to gonadotropin-releasing hormone)|ensembl:ENSMUSG00000027712(gene)|ensembl:ENSMUST00000029266(transcript)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007596"(blood coagulation)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010033"(response to organic substance)|go:"GO:0014704"(intercalated disc)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0030018"(Z disc)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0030425"(dendrite)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0043679"(axon terminus)|go:"GO:0051592"(response to calcium ion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0072563"(endothelial microparticle)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:CJEThujZVYsg5/wpN8fAMdpY38U10090	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	intact-crc:297B281D81F2880C|rigid:cvbVxYnNhSSiltwY9pu+kKkFw6Q	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P48036	uniprotkb:Q08460	intact:EBI-1184119|uniprotkb:Q3U5Q1|uniprotkb:Q3U5X4|uniprotkb:Q3U8K1|uniprotkb:Q3UGV0|uniprotkb:Q99LA1|ensembl:ENSMUSP00000029266	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	psi-mi:anxa5_mouse(display_long)|uniprotkb:Anxa5(gene name)|psi-mi:Anxa5(display_short)|uniprotkb:Anx5(gene name synonym)|uniprotkb:Annexin-5(gene name synonym)|uniprotkb:Annexin V(gene name synonym)|uniprotkb:Lipocortin V(gene name synonym)|uniprotkb:Endonexin II(gene name synonym)|uniprotkb:Calphobindin I(gene name synonym)|uniprotkb:Placental anticoagulant protein I(gene name synonym)|uniprotkb:Placental anticoagulant protein 4(gene name synonym)|uniprotkb:Thromboplastin inhibitor(gene name synonym)|uniprotkb:Vascular anticoagulant-alpha(gene name synonym)|uniprotkb:Anchorin CII(gene name synonym)	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2128306|imex:IM-9475-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033803.1|go:"GO:1901317"(regulation of flagellated sperm motility)|go:"GO:1902721"(negative regulation of prolactin secretion)|interpro:IPR001464(Annexin)|interpro:IPR002392(Annexin, type V)|interpro:IPR018252|interpro:IPR018502|interpro:IPR037104|mint:P48036|reactome:R-MMU-114608|go:"GO:0097211"(cellular response to gonadotropin-releasing hormone)|ensembl:ENSMUSG00000027712(gene)|ensembl:ENSMUST00000029266(transcript)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007596"(blood coagulation)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010033"(response to organic substance)|go:"GO:0014704"(intercalated disc)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0030018"(Z disc)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0030425"(dendrite)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0043679"(axon terminus)|go:"GO:0051592"(response to calcium ion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0072563"(endothelial microparticle)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:CJEThujZVYsg5/wpN8fAMdpY38U10090	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	intact-crc:4AA96D5E68E5C2AC|rigid:cvbVxYnNhSSiltwY9pu+kKkFw6Q	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q08460	uniprotkb:P63260	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-351301|uniprotkb:P02571|uniprotkb:P14104|uniprotkb:P99022|ensembl:ENSMUSP00000071486|ensembl:ENSMUSP00000101822	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:actg_mouse(display_long)|uniprotkb:Actg1(gene name)|psi-mi:Actg1(display_short)|uniprotkb:Actg(gene name synonym)|uniprotkb:Gamma-actin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2128310|imex:IM-9475-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_033739.1|reactome:R-MMU-190873|reactome:R-MMU-196025|reactome:R-MMU-2029482|reactome:R-MMU-3928662|reactome:R-MMU-418990|reactome:R-MMU-437239|reactome:R-MMU-4420097|reactome:R-MMU-445095|reactome:R-MMU-446353|reactome:R-MMU-5626467|reactome:R-MMU-5663213|reactome:R-MMU-5663220|reactome:R-MMU-5674135|reactome:R-MMU-8856828|reactome:R-MMU-9013418|ensembl:ENSMUSG00000062825(gene)|ensembl:ENSMUST00000071555(transcript)|ensembl:ENSMUST00000106215(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005522"(profilin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030016"(myofibril)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0042802"(identical protein binding)|go:"GO:0043034"(costamere)|go:"GO:0043209"(myelin sheath)|go:"GO:0043296"(apical junction complex)|go:"GO:0044305"(calyx of Held)|go:"GO:0045177"(apical part of cell)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097433"(dense body)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0099143"(presynaptic actin cytoskeleton)|go:"GO:0120192"(tight junction assembly)|go:"GO:0120220"(basal body patch)|go:"GO:0150111"(regulation of transepithelial transport)|go:"GO:1902396"(protein localization to bicellular tight junction)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|interpro:IPR043129|reactome:R-MMU-114608	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:B2OOsE06lTfo90H3g8tlmUJQ7cY10090	intact-crc:2D00912A496F3506|rigid:xBGBDpeR7uOdxEoDNp2EYlHg/W8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q00623	uniprotkb:Q08460	intact:EBI-1634106|uniprotkb:Q8BPD5|uniprotkb:O08855|uniprotkb:O09042|ensembl:ENSMUSP00000034588	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	psi-mi:apoa1_mouse(display_long)|uniprotkb:Apoa1(gene name)|psi-mi:Apoa1(display_short)|uniprotkb:Apolipoprotein A1(gene name synonym)	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2128314|imex:IM-9475-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033822.2|ensembl:ENSMUSG00000032083(gene)|ensembl:ENSMUST00000034588(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006656"(phosphatidylcholine biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008211"(glucocorticoid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0009986"(cell surface)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010898"(positive regulation of triglyceride catabolic process)|go:"GO:0010903"(negative regulation of very-low-density lipoprotein particle remodeling)|go:"GO:0015485"(cholesterol binding)|go:"GO:0015914"(phospholipid transport)|go:"GO:0018158"(protein oxidation)|go:"GO:0018206"(peptidyl-methionine modification)|go:"GO:0019899"(enzyme binding)|go:"GO:0019915"(lipid storage)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030300"(regulation of intestinal cholesterol absorption)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030325"(adrenal gland development)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034190"(apolipoprotein receptor binding)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034363"(intermediate-density lipoprotein particle)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0034365"(discoidal high-density lipoprotein particle)|go:"GO:0034366"(spherical high-density lipoprotein particle)|go:"GO:0034372"(very-low-density lipoprotein particle remodeling)|go:"GO:0034375"(high-density lipoprotein particle remodeling)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042158"(lipoprotein biosynthetic process)|go:"GO:0042627"(chylomicron)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0045723"(positive regulation of fatty acid biosynthetic process)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050821"(protein stabilization)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0051180"(vitamin transport)|go:"GO:0051345"(positive regulation of hydrolase activity)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0055102"(lipase inhibitor activity)|go:"GO:0060192"(negative regulation of lipase activity)|go:"GO:0060228"(phosphatidylcholine-sterol O-acyltransferase activator activity)|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070508"(cholesterol import)|go:"GO:0070653"(high-density lipoprotein particle receptor binding)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902995"(positive regulation of phospholipid efflux)|interpro:IPR000074(Apolipoprotein A1/A4/E)|mint:Q00623|rcsb pdb:2LEM|reactome:R-MMU-114608|reactome:R-MMU-1369062|reactome:R-MMU-2168880|reactome:R-MMU-3000471|reactome:R-MMU-3000480|reactome:R-MMU-381426|reactome:R-MMU-8957275|reactome:R-MMU-8963888|reactome:R-MMU-8963896|reactome:R-MMU-8963901|reactome:R-MMU-8964011|reactome:R-MMU-8964058|reactome:R-MMU-9707616|reactome:R-MMU-975634	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:RFvdsVcof99jM6K/bEi1N1Vn9hE10090	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	intact-crc:86286C3D2EE643C3|rigid:VJJwVUbnSGWf9+lxXFCxjW4MKHc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q08460	uniprotkb:Q00623	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634106|uniprotkb:Q8BPD5|uniprotkb:O08855|uniprotkb:O09042|ensembl:ENSMUSP00000034588	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:apoa1_mouse(display_long)|uniprotkb:Apoa1(gene name)|psi-mi:Apoa1(display_short)|uniprotkb:Apolipoprotein A1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2128319|imex:IM-9475-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_033822.2|ensembl:ENSMUSG00000032083(gene)|ensembl:ENSMUST00000034588(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006656"(phosphatidylcholine biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008211"(glucocorticoid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0009986"(cell surface)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010898"(positive regulation of triglyceride catabolic process)|go:"GO:0010903"(negative regulation of very-low-density lipoprotein particle remodeling)|go:"GO:0015485"(cholesterol binding)|go:"GO:0015914"(phospholipid transport)|go:"GO:0018158"(protein oxidation)|go:"GO:0018206"(peptidyl-methionine modification)|go:"GO:0019899"(enzyme binding)|go:"GO:0019915"(lipid storage)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030300"(regulation of intestinal cholesterol absorption)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030325"(adrenal gland development)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034190"(apolipoprotein receptor binding)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034363"(intermediate-density lipoprotein particle)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0034365"(discoidal high-density lipoprotein particle)|go:"GO:0034366"(spherical high-density lipoprotein particle)|go:"GO:0034372"(very-low-density lipoprotein particle remodeling)|go:"GO:0034375"(high-density lipoprotein particle remodeling)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042158"(lipoprotein biosynthetic process)|go:"GO:0042627"(chylomicron)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0045723"(positive regulation of fatty acid biosynthetic process)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050821"(protein stabilization)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0051180"(vitamin transport)|go:"GO:0051345"(positive regulation of hydrolase activity)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0055102"(lipase inhibitor activity)|go:"GO:0060192"(negative regulation of lipase activity)|go:"GO:0060228"(phosphatidylcholine-sterol O-acyltransferase activator activity)|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070508"(cholesterol import)|go:"GO:0070653"(high-density lipoprotein particle receptor binding)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902995"(positive regulation of phospholipid efflux)|interpro:IPR000074(Apolipoprotein A1/A4/E)|mint:Q00623|rcsb pdb:2LEM|reactome:R-MMU-114608|reactome:R-MMU-1369062|reactome:R-MMU-2168880|reactome:R-MMU-3000471|reactome:R-MMU-3000480|reactome:R-MMU-381426|reactome:R-MMU-8957275|reactome:R-MMU-8963888|reactome:R-MMU-8963896|reactome:R-MMU-8963901|reactome:R-MMU-8964011|reactome:R-MMU-8964058|reactome:R-MMU-9707616|reactome:R-MMU-975634	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:RFvdsVcof99jM6K/bEi1N1Vn9hE10090	intact-crc:E6A5E9DC43A3DFED|rigid:VJJwVUbnSGWf9+lxXFCxjW4MKHc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P62204	uniprotkb:Q08460	intact:EBI-397460|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q3TEH7|uniprotkb:Q3THK5|uniprotkb:Q3U6Z5|uniprotkb:Q3U7C7|uniprotkb:Q498A3|uniprotkb:Q61379|uniprotkb:Q61380|uniprotkb:Q8BNC9|uniprotkb:Q91VQ9|uniprotkb:Q9D6G4|dip:DIP-31550N|uniprotkb:P0DP26|uniprotkb:P0DP28	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	psi-mi:calm_mouse(display_long)|uniprotkb:Calm1(gene name)|psi-mi:Calm1(display_short)|uniprotkb:Calm(gene name synonym)|uniprotkb:Cam1(gene name synonym)|uniprotkb:Calm2(gene name)|psi-mi:Calm2(display_short)|uniprotkb:Cam2(gene name synonym)|uniprotkb:Camb(gene name synonym)|uniprotkb:Calm3(gene name)|psi-mi:Calm3(display_short)|uniprotkb:Cam3(gene name synonym)|uniprotkb:Camc(gene name synonym)|uniprotkb:Cam(gene name synonym)	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2128324|imex:IM-9475-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:3WFN|rcsb pdb:4HEX|go:"GO:0005509"(calcium ion binding)|go:"GO:0000922"(spindle pole)|refseq:NP_031615.1|refseq:NP_031616.1|refseq:NP_033920.1|rcsb pdb:2IX7|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|rcsb pdb:2DFS|refseq:NP_001300863.1|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0043388"(positive regulation of DNA binding)|reactome:R-MMU-2672351|reactome:R-MMU-418359|reactome:R-MMU-425561|reactome:R-MMU-5578775|reactome:R-MMU-936837|go:"GO:0005829"(cytosol)|reactome:R-MMU-8876725|rcsb pdb:4E50|rcsb pdb:4E53|go:"GO:0061024"(membrane organization)|rcsb pdb:4ZLK|reactome:R-MMU-1445148|reactome:R-MMU-5576892|ensembl:ENSMUST00000019514|ensembl:ENSMUST00000040440|ensembl:ENSMUST00000110082|reactome:R-MMU-111932|reactome:R-MMU-111933|reactome:R-MMU-111957|reactome:R-MMU-114608|reactome:R-MMU-1474151|reactome:R-MMU-1855204|reactome:R-MMU-203615|reactome:R-MMU-2871809|reactome:R-MMU-4086398|reactome:R-MMU-442717|reactome:R-MMU-442729|reactome:R-MMU-442745|reactome:R-MMU-442982|reactome:R-MMU-445355|reactome:R-MMU-451308|reactome:R-MMU-5607763|reactome:R-MMU-5626467|reactome:R-MMU-5218920|reactome:R-MMU-5627123|reactome:R-MMU-5673001|reactome:R-MMU-70221|ensembl:ENSMUSG00000001175|ensembl:ENSMUSG00000019370|ensembl:ENSMUSG00000036438|ensembl:ENSMUSP00000019514|ensembl:ENSMUSP00000048857|ensembl:ENSMUSP00000105709|reactome:R-MMU-2514859|reactome:R-MMU-163615|go:"GO:0034704"(calcium channel complex)|go:"GO:0005813"(centrosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030426"(growth cone)|go:"GO:0005634"(nucleus)|go:"GO:0030017"(sarcomere)|go:"GO:0005876"(spindle microtubule)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0002027"(regulation of heart rate)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0001975"(response to amphetamine)|go:"GO:0051412"(response to corticosterone)|go:"GO:0021762"(substantia nigra development)|rcsb pdb:1UP5|go:"GO:1902494"(catalytic complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0043209"(myelin sheath)|go:"GO:0014069"(postsynaptic density)|go:"GO:0043234"|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031432"(titin binding)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0030819"(obsolete positive regulation of cAMP biosynthetic process)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|reactome:R-MMU-2025928|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0005886"(plasma membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031997"(N-terminal myristoylation domain binding)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0031800"(type 3 metabotropic glutamate receptor binding)|go:"GO:0090151"(establishment of protein localization to mitochondrial membrane)|go:"GO:0075206"(obsolete positive regulation by host of symbiont cAMP-mediated signal transduction)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:0051300"(spindle pole body organization)|interpro:IPR039030	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:tTYcOd9bOh211njZVz7cYVybAMQ10090	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	intact-crc:615D58417DC48CE0|rigid:hRKdNP+KWdCgYns4sKrJR9nU7pM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q08460	uniprotkb:P62204	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-397460|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q3TEH7|uniprotkb:Q3THK5|uniprotkb:Q3U6Z5|uniprotkb:Q3U7C7|uniprotkb:Q498A3|uniprotkb:Q61379|uniprotkb:Q61380|uniprotkb:Q8BNC9|uniprotkb:Q91VQ9|uniprotkb:Q9D6G4|dip:DIP-31550N|uniprotkb:P0DP26|uniprotkb:P0DP28	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:calm_mouse(display_long)|uniprotkb:Calm1(gene name)|psi-mi:Calm1(display_short)|uniprotkb:Calm(gene name synonym)|uniprotkb:Cam1(gene name synonym)|uniprotkb:Calm2(gene name)|psi-mi:Calm2(display_short)|uniprotkb:Cam2(gene name synonym)|uniprotkb:Camb(gene name synonym)|uniprotkb:Calm3(gene name)|psi-mi:Calm3(display_short)|uniprotkb:Cam3(gene name synonym)|uniprotkb:Camc(gene name synonym)|uniprotkb:Cam(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2128328|imex:IM-9475-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	rcsb pdb:3WFN|rcsb pdb:4HEX|go:"GO:0005509"(calcium ion binding)|go:"GO:0000922"(spindle pole)|refseq:NP_031615.1|refseq:NP_031616.1|refseq:NP_033920.1|rcsb pdb:2IX7|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|rcsb pdb:2DFS|refseq:NP_001300863.1|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0043388"(positive regulation of DNA binding)|reactome:R-MMU-2672351|reactome:R-MMU-418359|reactome:R-MMU-425561|reactome:R-MMU-5578775|reactome:R-MMU-936837|go:"GO:0005829"(cytosol)|reactome:R-MMU-8876725|rcsb pdb:4E50|rcsb pdb:4E53|go:"GO:0061024"(membrane organization)|rcsb pdb:4ZLK|reactome:R-MMU-1445148|reactome:R-MMU-5576892|ensembl:ENSMUST00000019514|ensembl:ENSMUST00000040440|ensembl:ENSMUST00000110082|reactome:R-MMU-111932|reactome:R-MMU-111933|reactome:R-MMU-111957|reactome:R-MMU-114608|reactome:R-MMU-1474151|reactome:R-MMU-1855204|reactome:R-MMU-203615|reactome:R-MMU-2871809|reactome:R-MMU-4086398|reactome:R-MMU-442717|reactome:R-MMU-442729|reactome:R-MMU-442745|reactome:R-MMU-442982|reactome:R-MMU-445355|reactome:R-MMU-451308|reactome:R-MMU-5607763|reactome:R-MMU-5626467|reactome:R-MMU-5218920|reactome:R-MMU-5627123|reactome:R-MMU-5673001|reactome:R-MMU-70221|ensembl:ENSMUSG00000001175|ensembl:ENSMUSG00000019370|ensembl:ENSMUSG00000036438|ensembl:ENSMUSP00000019514|ensembl:ENSMUSP00000048857|ensembl:ENSMUSP00000105709|reactome:R-MMU-2514859|reactome:R-MMU-163615|go:"GO:0034704"(calcium channel complex)|go:"GO:0005813"(centrosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030426"(growth cone)|go:"GO:0005634"(nucleus)|go:"GO:0030017"(sarcomere)|go:"GO:0005876"(spindle microtubule)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0002027"(regulation of heart rate)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0001975"(response to amphetamine)|go:"GO:0051412"(response to corticosterone)|go:"GO:0021762"(substantia nigra development)|rcsb pdb:1UP5|go:"GO:1902494"(catalytic complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0043209"(myelin sheath)|go:"GO:0014069"(postsynaptic density)|go:"GO:0043234"|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031432"(titin binding)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0030819"(obsolete positive regulation of cAMP biosynthetic process)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|reactome:R-MMU-2025928|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0005886"(plasma membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031997"(N-terminal myristoylation domain binding)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0031800"(type 3 metabotropic glutamate receptor binding)|go:"GO:0090151"(establishment of protein localization to mitochondrial membrane)|go:"GO:0075206"(obsolete positive regulation by host of symbiont cAMP-mediated signal transduction)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:0051300"(spindle pole body organization)|interpro:IPR039030	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:tTYcOd9bOh211njZVz7cYVybAMQ10090	intact-crc:30AB0E0C286A1607|rigid:hRKdNP+KWdCgYns4sKrJR9nU7pM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P16858	uniprotkb:Q08460	intact:EBI-444871|uniprotkb:Q0QEU0|uniprotkb:Q3THM2|uniprotkb:Q3TUI2|uniprotkb:Q3UMT2|uniprotkb:Q4V783|uniprotkb:Q569X2|uniprotkb:Q569X5|uniprotkb:Q5U410|uniprotkb:A6H6A8|ensembl:ENSMUSP00000073289|ensembl:ENSMUSP00000113213	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	psi-mi:g3p_mouse(display_long)|uniprotkb:Gapdh(gene name)|psi-mi:Gapdh(display_short)|uniprotkb:Gapd(gene name synonym)|uniprotkb:Peptidyl-cysteine S-nitrosylase GAPDH(gene name synonym)	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2128335|imex:IM-9475-18	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032110.1|refseq:XP_001476757.1|ensembl:ENSMUSG00000057666(gene)|ensembl:ENSMUST00000073605(transcript)|ensembl:ENSMUST00000118875(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0004365"("glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006096"(glycolytic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0008017"(microtubule binding)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031906"(late endosome lumen)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0035605"(peptidyl-cysteine S-nitrosylase activity)|go:"GO:0035606"(peptidyl-cysteine S-trans-nitrosylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050661"(NADP binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051287"(NAD binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0060359"(response to ammonium ion)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097452"(GAIT complex)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1905460"(negative regulation of vascular associated smooth muscle cell apoptotic process)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006424(Glyceraldehyde-3-phosphate dehydrogenase, type I)|interpro:IPR020828|interpro:IPR020829|interpro:IPR020830|interpro:IPR020831|interpro:IPR036291|mint:P16858|rcsb pdb:6LGJ|rcsb pdb:6LGK|rcsb pdb:6LGM|reactome:R-MMU-70171|reactome:R-MMU-70263|refseq:NP_001276655.1|dip:DIP-31404N	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:SkcdXZ+143DDQFioo6mNWNpCLTI10090	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	intact-crc:462413225DB191C6|rigid:u2JH6BptugWobgP2+JCXsN3iGsQ	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P16858	uniprotkb:Q08460	intact:EBI-444871|uniprotkb:Q0QEU0|uniprotkb:Q3THM2|uniprotkb:Q3TUI2|uniprotkb:Q3UMT2|uniprotkb:Q4V783|uniprotkb:Q569X2|uniprotkb:Q569X5|uniprotkb:Q5U410|uniprotkb:A6H6A8|ensembl:ENSMUSP00000073289|ensembl:ENSMUSP00000113213	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	psi-mi:g3p_mouse(display_long)|uniprotkb:Gapdh(gene name)|psi-mi:Gapdh(display_short)|uniprotkb:Gapd(gene name synonym)|uniprotkb:Peptidyl-cysteine S-nitrosylase GAPDH(gene name synonym)	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2128339|imex:IM-9475-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032110.1|refseq:XP_001476757.1|ensembl:ENSMUSG00000057666(gene)|ensembl:ENSMUST00000073605(transcript)|ensembl:ENSMUST00000118875(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0004365"("glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006096"(glycolytic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0008017"(microtubule binding)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031906"(late endosome lumen)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0035605"(peptidyl-cysteine S-nitrosylase activity)|go:"GO:0035606"(peptidyl-cysteine S-trans-nitrosylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050661"(NADP binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051287"(NAD binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0060359"(response to ammonium ion)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097452"(GAIT complex)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1905460"(negative regulation of vascular associated smooth muscle cell apoptotic process)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006424(Glyceraldehyde-3-phosphate dehydrogenase, type I)|interpro:IPR020828|interpro:IPR020829|interpro:IPR020830|interpro:IPR020831|interpro:IPR036291|mint:P16858|rcsb pdb:6LGJ|rcsb pdb:6LGK|rcsb pdb:6LGM|reactome:R-MMU-70171|reactome:R-MMU-70263|refseq:NP_001276655.1|dip:DIP-31404N	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:SkcdXZ+143DDQFioo6mNWNpCLTI10090	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	intact-crc:CA5E93DCC19BB1DE|rigid:u2JH6BptugWobgP2+JCXsN3iGsQ	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q08460	uniprotkb:P84075	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-2128343|uniprotkb:P32076|uniprotkb:P41211|uniprotkb:P70510|uniprotkb:A2A7R4|ensembl:ENSMUSP00000030572|ensembl:ENSMUSP00000093486|ensembl:ENSMUSP00000112143|ensembl:ENSMUSP00000112145|ensembl:ENSMUSP00000119178|ensembl:ENSMUSP00000129548	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:hpca_mouse(display_long)|uniprotkb:Hpca(gene name)|psi-mi:Hpca(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2128358|imex:IM-9475-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_001273010.1|refseq:NP_001273012.1|refseq:XP_011238748.1|refseq:NP_001123891.1|refseq:NP_034601.1|ensembl:ENSMUSG00000028785|refseq:XP_006502838.1|refseq:XP_006502839.1|refseq:XP_006502840.1|ensembl:ENSMUSG00000028785(gene)|ensembl:ENSMUST00000030572(transcript)|ensembl:ENSMUST00000095807(transcript)|ensembl:ENSMUST00000116442(transcript)|ensembl:ENSMUST00000116444(transcript)|ensembl:ENSMUST00000139450(transcript)|ensembl:ENSMUST00000164649(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007420"(brain development)|go:"GO:0010518"(positive regulation of phospholipase activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019900"(kinase binding)|go:"GO:0030424"(axon)|go:"GO:0031283"(negative regulation of guanylate cyclase activity)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0044327"(dendritic spine head)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0048839"(inner ear development)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1901385"(regulation of voltage-gated calcium channel activity)|go:"GO:1901986"(response to ketamine)|go:"GO:1902065"(response to L-glutamate)|go:"GO:1904009"(cellular response to monosodium glutamate)|go:"GO:1904010"(response to Aroclor 1254)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR028846|mint:P84075	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:uqRvTKlr8zMg7+UAfYCSqOljrFc10090	intact-crc:DC6573CE674068B1|rigid:/vZuXBZsWrL1LDJX77jXe9ih1+U	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q08460	uniprotkb:P84075	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-2128343|uniprotkb:P32076|uniprotkb:P41211|uniprotkb:P70510|uniprotkb:A2A7R4|ensembl:ENSMUSP00000030572|ensembl:ENSMUSP00000093486|ensembl:ENSMUSP00000112143|ensembl:ENSMUSP00000112145|ensembl:ENSMUSP00000119178|ensembl:ENSMUSP00000129548	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:hpca_mouse(display_long)|uniprotkb:Hpca(gene name)|psi-mi:Hpca(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2128362|imex:IM-9475-20	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_001273010.1|refseq:NP_001273012.1|refseq:XP_011238748.1|refseq:NP_001123891.1|refseq:NP_034601.1|ensembl:ENSMUSG00000028785|refseq:XP_006502838.1|refseq:XP_006502839.1|refseq:XP_006502840.1|ensembl:ENSMUSG00000028785(gene)|ensembl:ENSMUST00000030572(transcript)|ensembl:ENSMUST00000095807(transcript)|ensembl:ENSMUST00000116442(transcript)|ensembl:ENSMUST00000116444(transcript)|ensembl:ENSMUST00000139450(transcript)|ensembl:ENSMUST00000164649(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007420"(brain development)|go:"GO:0010518"(positive regulation of phospholipase activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019900"(kinase binding)|go:"GO:0030424"(axon)|go:"GO:0031283"(negative regulation of guanylate cyclase activity)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0044327"(dendritic spine head)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0048839"(inner ear development)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1901385"(regulation of voltage-gated calcium channel activity)|go:"GO:1901986"(response to ketamine)|go:"GO:1902065"(response to L-glutamate)|go:"GO:1904009"(cellular response to monosodium glutamate)|go:"GO:1904010"(response to Aroclor 1254)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR028846|mint:P84075	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:uqRvTKlr8zMg7+UAfYCSqOljrFc10090	intact-crc:59D4F6EBB9BDF1FE|rigid:/vZuXBZsWrL1LDJX77jXe9ih1+U	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O88952	uniprotkb:Q08460	intact:EBI-821316|ensembl:ENSMUSP00000028583	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	psi-mi:lin7c_mouse(display_long)|uniprotkb:Mammalian lin-seven protein 3(gene name synonym)|uniprotkb:Vertebrate lin-7 homolog 3(gene name synonym)|uniprotkb:Veli3(gene name synonym)|uniprotkb:Lin7c(gene name)|psi-mi:Lin7c(display_short)|uniprotkb:Mals3(gene name synonym)	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2128371|imex:IM-9475-22	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035829.1|ensembl:ENSMUSG00000027162(gene)|ensembl:ENSMUST00000028583(transcript)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006887"(exocytosis)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0045202"(synapse)|go:"GO:0097016"(L27 domain binding)|go:"GO:0097025"(MPP7-DLG1-LIN7 complex)|go:"GO:0098793"(presynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903361"(protein localization to basolateral plasma membrane)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR014775(L27, C-terminal)|interpro:IPR017365(Lin-7 homologue)|interpro:IPR036034|interpro:IPR036892|reactome:R-MMU-212676	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:F2rasaJ64Olc9qScN79LJRqsUEE10090	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	intact-crc:CE7985AB5C96A59E|rigid:1cDdHEaSabdEp2QuY2dQDAHmhEs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q08460	uniprotkb:O88952	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-821316|ensembl:ENSMUSP00000028583	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:lin7c_mouse(display_long)|uniprotkb:Mammalian lin-seven protein 3(gene name synonym)|uniprotkb:Vertebrate lin-7 homolog 3(gene name synonym)|uniprotkb:Veli3(gene name synonym)|uniprotkb:Lin7c(gene name)|psi-mi:Lin7c(display_short)|uniprotkb:Mals3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2128381|imex:IM-9475-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_035829.1|ensembl:ENSMUSG00000027162(gene)|ensembl:ENSMUST00000028583(transcript)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006887"(exocytosis)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0045202"(synapse)|go:"GO:0097016"(L27 domain binding)|go:"GO:0097025"(MPP7-DLG1-LIN7 complex)|go:"GO:0098793"(presynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903361"(protein localization to basolateral plasma membrane)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR014775(L27, C-terminal)|interpro:IPR017365(Lin-7 homologue)|interpro:IPR036034|interpro:IPR036892|reactome:R-MMU-212676	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:F2rasaJ64Olc9qScN79LJRqsUEE10090	intact-crc:66B5044ED9D29371|rigid:1cDdHEaSabdEp2QuY2dQDAHmhEs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P27573	uniprotkb:Q08460	intact:EBI-1634589|uniprotkb:Q542C9	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	psi-mi:myp0_mouse(display_long)|uniprotkb:Mpz(gene name)|psi-mi:Mpz(display_short)|uniprotkb:P0(gene name synonym)|uniprotkb:Myelin protein zero(gene name synonym)|uniprotkb:Myelin peripheral protein(gene name synonym)	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2128387|imex:IM-9475-24	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001302428.1|refseq:NP_001302429.1|refseq:NP_032649.2|dip:DIP-51664N|go:"GO:0005764"(lysosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0042552"(myelination)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043209"(myelin sheath)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098743"(cell aggregation)|interpro:IPR000920(Myelin P0 protein)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR019566|interpro:IPR019738|interpro:IPR029869|interpro:IPR036179	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:n7Go3hYQ/2jR857QJQnI5GWwqrc10090	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	intact-crc:4356FC80405B2878|rigid:QGOhL2ww11vR4bhrhj4blZNwXRE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q08460	uniprotkb:P27573	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634589|uniprotkb:Q542C9	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:myp0_mouse(display_long)|uniprotkb:Mpz(gene name)|psi-mi:Mpz(display_short)|uniprotkb:P0(gene name synonym)|uniprotkb:Myelin protein zero(gene name synonym)|uniprotkb:Myelin peripheral protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2128391|imex:IM-9475-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_001302428.1|refseq:NP_001302429.1|refseq:NP_032649.2|dip:DIP-51664N|go:"GO:0005764"(lysosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0042552"(myelination)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043209"(myelin sheath)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098743"(cell aggregation)|interpro:IPR000920(Myelin P0 protein)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR019566|interpro:IPR019738|interpro:IPR029869|interpro:IPR036179	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:n7Go3hYQ/2jR857QJQnI5GWwqrc10090	intact-crc:EB2B65B7777A9B30|rigid:QGOhL2ww11vR4bhrhj4blZNwXRE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q08460	uniprotkb:P61982	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-359843|uniprotkb:O70457|uniprotkb:P35214|uniprotkb:Q4FK44|uniprotkb:Q3UFD6|uniprotkb:Q9UDP2|uniprotkb:Q9UN99|ensembl:ENSMUSP00000051223|ensembl:ENSMUSP00000143631	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:1433g_mouse(display_long)|uniprotkb:Ywhag(gene name)|psi-mi:Ywhag(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2128397|imex:IM-9475-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_061359.2|ensembl:ENSMUSG00000051391(gene)|ensembl:ENSMUST00000055808(transcript)|ensembl:ENSMUST00000198270(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0006605"(protein targeting)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031982"(vesicle)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0045202"(synapse)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0098793"(presynapse)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P61982|reactome:R-MMU-111447|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-8854518|reactome:R-MMU-9614399	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:u1cd71h0RPgTOEMrQVhOelsxWnM10090	intact-crc:A1DB7DB22D5DDCDC|rigid:YAd1yh9LujcJAWhA12Cx5D1UjSY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P61982	uniprotkb:Q08460	intact:EBI-359843|uniprotkb:O70457|uniprotkb:P35214|uniprotkb:Q4FK44|uniprotkb:Q3UFD6|uniprotkb:Q9UDP2|uniprotkb:Q9UN99|ensembl:ENSMUSP00000051223|ensembl:ENSMUSP00000143631	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	psi-mi:1433g_mouse(display_long)|uniprotkb:Ywhag(gene name)|psi-mi:Ywhag(display_short)	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2128401|imex:IM-9475-28	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_061359.2|ensembl:ENSMUSG00000051391(gene)|ensembl:ENSMUST00000055808(transcript)|ensembl:ENSMUST00000198270(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0006605"(protein targeting)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031982"(vesicle)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0045202"(synapse)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0098793"(presynapse)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P61982|reactome:R-MMU-111447|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-8854518|reactome:R-MMU-9614399	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:u1cd71h0RPgTOEMrQVhOelsxWnM10090	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	intact-crc:87DAD3162D0AAFCF|rigid:YAd1yh9LujcJAWhA12Cx5D1UjSY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q08460	uniprotkb:P48036	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1184119|uniprotkb:Q3U5Q1|uniprotkb:Q3U5X4|uniprotkb:Q3U8K1|uniprotkb:Q3UGV0|uniprotkb:Q99LA1|ensembl:ENSMUSP00000029266	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:anxa5_mouse(display_long)|uniprotkb:Anxa5(gene name)|psi-mi:Anxa5(display_short)|uniprotkb:Anx5(gene name synonym)|uniprotkb:Annexin-5(gene name synonym)|uniprotkb:Annexin V(gene name synonym)|uniprotkb:Lipocortin V(gene name synonym)|uniprotkb:Endonexin II(gene name synonym)|uniprotkb:Calphobindin I(gene name synonym)|uniprotkb:Placental anticoagulant protein I(gene name synonym)|uniprotkb:Placental anticoagulant protein 4(gene name synonym)|uniprotkb:Thromboplastin inhibitor(gene name synonym)|uniprotkb:Vascular anticoagulant-alpha(gene name synonym)|uniprotkb:Anchorin CII(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2128410|imex:IM-9475-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_033803.1|go:"GO:1901317"(regulation of flagellated sperm motility)|go:"GO:1902721"(negative regulation of prolactin secretion)|interpro:IPR001464(Annexin)|interpro:IPR002392(Annexin, type V)|interpro:IPR018252|interpro:IPR018502|interpro:IPR037104|mint:P48036|reactome:R-MMU-114608|go:"GO:0097211"(cellular response to gonadotropin-releasing hormone)|ensembl:ENSMUSG00000027712(gene)|ensembl:ENSMUST00000029266(transcript)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007596"(blood coagulation)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010033"(response to organic substance)|go:"GO:0014704"(intercalated disc)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0030018"(Z disc)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0030425"(dendrite)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0043679"(axon terminus)|go:"GO:0051592"(response to calcium ion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0072563"(endothelial microparticle)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3|comment:Proteins colocalise in in inner and outer hair cells, and ganglion cells|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:CJEThujZVYsg5/wpN8fAMdpY38U10090	intact-crc:9AC1D31658D1AB54|rigid:cvbVxYnNhSSiltwY9pu+kKkFw6Q	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q08460	uniprotkb:P63260	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-351301|uniprotkb:P02571|uniprotkb:P14104|uniprotkb:P99022|ensembl:ENSMUSP00000071486|ensembl:ENSMUSP00000101822	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:actg_mouse(display_long)|uniprotkb:Actg1(gene name)|psi-mi:Actg1(display_short)|uniprotkb:Actg(gene name synonym)|uniprotkb:Gamma-actin(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2128415|imex:IM-9475-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_033739.1|reactome:R-MMU-190873|reactome:R-MMU-196025|reactome:R-MMU-2029482|reactome:R-MMU-3928662|reactome:R-MMU-418990|reactome:R-MMU-437239|reactome:R-MMU-4420097|reactome:R-MMU-445095|reactome:R-MMU-446353|reactome:R-MMU-5626467|reactome:R-MMU-5663213|reactome:R-MMU-5663220|reactome:R-MMU-5674135|reactome:R-MMU-8856828|reactome:R-MMU-9013418|ensembl:ENSMUSG00000062825(gene)|ensembl:ENSMUST00000071555(transcript)|ensembl:ENSMUST00000106215(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005522"(profilin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030016"(myofibril)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0042802"(identical protein binding)|go:"GO:0043034"(costamere)|go:"GO:0043209"(myelin sheath)|go:"GO:0043296"(apical junction complex)|go:"GO:0044305"(calyx of Held)|go:"GO:0045177"(apical part of cell)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097433"(dense body)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0099143"(presynaptic actin cytoskeleton)|go:"GO:0120192"(tight junction assembly)|go:"GO:0120220"(basal body patch)|go:"GO:0150111"(regulation of transepithelial transport)|go:"GO:1902396"(protein localization to bicellular tight junction)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|interpro:IPR043129|reactome:R-MMU-114608	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3|comment:Proteins colocalise in inner and outer hair cells, and ganglion cells.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:B2OOsE06lTfo90H3g8tlmUJQ7cY10090	intact-crc:E5AE42B85CA36114|rigid:xBGBDpeR7uOdxEoDNp2EYlHg/W8	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q08460	uniprotkb:Q00623	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634106|uniprotkb:Q8BPD5|uniprotkb:O08855|uniprotkb:O09042|ensembl:ENSMUSP00000034588	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:apoa1_mouse(display_long)|uniprotkb:Apoa1(gene name)|psi-mi:Apoa1(display_short)|uniprotkb:Apolipoprotein A1(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2128420|imex:IM-9475-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_033822.2|ensembl:ENSMUSG00000032083(gene)|ensembl:ENSMUST00000034588(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006656"(phosphatidylcholine biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008211"(glucocorticoid metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0009986"(cell surface)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010898"(positive regulation of triglyceride catabolic process)|go:"GO:0010903"(negative regulation of very-low-density lipoprotein particle remodeling)|go:"GO:0015485"(cholesterol binding)|go:"GO:0015914"(phospholipid transport)|go:"GO:0018158"(protein oxidation)|go:"GO:0018206"(peptidyl-methionine modification)|go:"GO:0019899"(enzyme binding)|go:"GO:0019915"(lipid storage)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030300"(regulation of intestinal cholesterol absorption)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030325"(adrenal gland development)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034190"(apolipoprotein receptor binding)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034363"(intermediate-density lipoprotein particle)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0034365"(discoidal high-density lipoprotein particle)|go:"GO:0034366"(spherical high-density lipoprotein particle)|go:"GO:0034372"(very-low-density lipoprotein particle remodeling)|go:"GO:0034375"(high-density lipoprotein particle remodeling)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042158"(lipoprotein biosynthetic process)|go:"GO:0042627"(chylomicron)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0045723"(positive regulation of fatty acid biosynthetic process)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050821"(protein stabilization)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0051180"(vitamin transport)|go:"GO:0051345"(positive regulation of hydrolase activity)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0055102"(lipase inhibitor activity)|go:"GO:0060192"(negative regulation of lipase activity)|go:"GO:0060228"(phosphatidylcholine-sterol O-acyltransferase activator activity)|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070508"(cholesterol import)|go:"GO:0070653"(high-density lipoprotein particle receptor binding)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902995"(positive regulation of phospholipid efflux)|interpro:IPR000074(Apolipoprotein A1/A4/E)|mint:Q00623|rcsb pdb:2LEM|reactome:R-MMU-114608|reactome:R-MMU-1369062|reactome:R-MMU-2168880|reactome:R-MMU-3000471|reactome:R-MMU-3000480|reactome:R-MMU-381426|reactome:R-MMU-8957275|reactome:R-MMU-8963888|reactome:R-MMU-8963896|reactome:R-MMU-8963901|reactome:R-MMU-8964011|reactome:R-MMU-8964058|reactome:R-MMU-9707616|reactome:R-MMU-975634	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3|comment:Proteins colocalise in inner and outer hair cells, and ganglion cells.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:RFvdsVcof99jM6K/bEi1N1Vn9hE10090	intact-crc:87D859DA525CE9AE|rigid:VJJwVUbnSGWf9+lxXFCxjW4MKHc	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q08460	uniprotkb:P62204	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-397460|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q3TEH7|uniprotkb:Q3THK5|uniprotkb:Q3U6Z5|uniprotkb:Q3U7C7|uniprotkb:Q498A3|uniprotkb:Q61379|uniprotkb:Q61380|uniprotkb:Q8BNC9|uniprotkb:Q91VQ9|uniprotkb:Q9D6G4|dip:DIP-31550N|uniprotkb:P0DP26|uniprotkb:P0DP28	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:calm_mouse(display_long)|uniprotkb:Calm1(gene name)|psi-mi:Calm1(display_short)|uniprotkb:Calm(gene name synonym)|uniprotkb:Cam1(gene name synonym)|uniprotkb:Calm2(gene name)|psi-mi:Calm2(display_short)|uniprotkb:Cam2(gene name synonym)|uniprotkb:Camb(gene name synonym)|uniprotkb:Calm3(gene name)|psi-mi:Calm3(display_short)|uniprotkb:Cam3(gene name synonym)|uniprotkb:Camc(gene name synonym)|uniprotkb:Cam(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2128425|imex:IM-9475-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	rcsb pdb:3WFN|rcsb pdb:4HEX|go:"GO:0005509"(calcium ion binding)|go:"GO:0000922"(spindle pole)|refseq:NP_031615.1|refseq:NP_031616.1|refseq:NP_033920.1|rcsb pdb:2IX7|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|rcsb pdb:2DFS|refseq:NP_001300863.1|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0043388"(positive regulation of DNA binding)|reactome:R-MMU-2672351|reactome:R-MMU-418359|reactome:R-MMU-425561|reactome:R-MMU-5578775|reactome:R-MMU-936837|go:"GO:0005829"(cytosol)|reactome:R-MMU-8876725|rcsb pdb:4E50|rcsb pdb:4E53|go:"GO:0061024"(membrane organization)|rcsb pdb:4ZLK|reactome:R-MMU-1445148|reactome:R-MMU-5576892|ensembl:ENSMUST00000019514|ensembl:ENSMUST00000040440|ensembl:ENSMUST00000110082|reactome:R-MMU-111932|reactome:R-MMU-111933|reactome:R-MMU-111957|reactome:R-MMU-114608|reactome:R-MMU-1474151|reactome:R-MMU-1855204|reactome:R-MMU-203615|reactome:R-MMU-2871809|reactome:R-MMU-4086398|reactome:R-MMU-442717|reactome:R-MMU-442729|reactome:R-MMU-442745|reactome:R-MMU-442982|reactome:R-MMU-445355|reactome:R-MMU-451308|reactome:R-MMU-5607763|reactome:R-MMU-5626467|reactome:R-MMU-5218920|reactome:R-MMU-5627123|reactome:R-MMU-5673001|reactome:R-MMU-70221|ensembl:ENSMUSG00000001175|ensembl:ENSMUSG00000019370|ensembl:ENSMUSG00000036438|ensembl:ENSMUSP00000019514|ensembl:ENSMUSP00000048857|ensembl:ENSMUSP00000105709|reactome:R-MMU-2514859|reactome:R-MMU-163615|go:"GO:0034704"(calcium channel complex)|go:"GO:0005813"(centrosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030426"(growth cone)|go:"GO:0005634"(nucleus)|go:"GO:0030017"(sarcomere)|go:"GO:0005876"(spindle microtubule)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0002027"(regulation of heart rate)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0001975"(response to amphetamine)|go:"GO:0051412"(response to corticosterone)|go:"GO:0021762"(substantia nigra development)|rcsb pdb:1UP5|go:"GO:1902494"(catalytic complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0043209"(myelin sheath)|go:"GO:0014069"(postsynaptic density)|go:"GO:0043234"|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031432"(titin binding)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0030819"(obsolete positive regulation of cAMP biosynthetic process)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|reactome:R-MMU-2025928|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0005886"(plasma membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031997"(N-terminal myristoylation domain binding)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0031800"(type 3 metabotropic glutamate receptor binding)|go:"GO:0090151"(establishment of protein localization to mitochondrial membrane)|go:"GO:0075206"(obsolete positive regulation by host of symbiont cAMP-mediated signal transduction)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:0051300"(spindle pole body organization)|interpro:IPR039030	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3|comment:Proteins colocalise in inner and outer hair cells, and ganglion cells.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:tTYcOd9bOh211njZVz7cYVybAMQ10090	intact-crc:2799A43383DA1115|rigid:hRKdNP+KWdCgYns4sKrJR9nU7pM	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q08460	uniprotkb:P61982	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-359843|uniprotkb:O70457|uniprotkb:P35214|uniprotkb:Q4FK44|uniprotkb:Q3UFD6|uniprotkb:Q9UDP2|uniprotkb:Q9UN99|ensembl:ENSMUSP00000051223|ensembl:ENSMUSP00000143631	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:1433g_mouse(display_long)|uniprotkb:Ywhag(gene name)|psi-mi:Ywhag(display_short)	psi-mi:"MI:0663"(confocal microscopy)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2128430|imex:IM-9475-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_061359.2|ensembl:ENSMUSG00000051391(gene)|ensembl:ENSMUST00000055808(transcript)|ensembl:ENSMUST00000198270(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0006605"(protein targeting)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031982"(vesicle)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0045202"(synapse)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0098793"(presynapse)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P61982|reactome:R-MMU-111447|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-8854518|reactome:R-MMU-9614399	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3|comment:Proteins colocalise in inner and outer hair cells, and ganglion cells.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:u1cd71h0RPgTOEMrQVhOelsxWnM10090	intact-crc:5F7F4AC742418114|rigid:YAd1yh9LujcJAWhA12Cx5D1UjSY	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q08460	uniprotkb:P16858	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-444871|uniprotkb:Q0QEU0|uniprotkb:Q3THM2|uniprotkb:Q3TUI2|uniprotkb:Q3UMT2|uniprotkb:Q4V783|uniprotkb:Q569X2|uniprotkb:Q569X5|uniprotkb:Q5U410|uniprotkb:A6H6A8|ensembl:ENSMUSP00000073289|ensembl:ENSMUSP00000113213	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:g3p_mouse(display_long)|uniprotkb:Gapdh(gene name)|psi-mi:Gapdh(display_short)|uniprotkb:Gapd(gene name synonym)|uniprotkb:Peptidyl-cysteine S-nitrosylase GAPDH(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2128435|imex:IM-9475-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_032110.1|refseq:XP_001476757.1|ensembl:ENSMUSG00000057666(gene)|ensembl:ENSMUST00000073605(transcript)|ensembl:ENSMUST00000118875(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0004365"("glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006096"(glycolytic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0008017"(microtubule binding)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031906"(late endosome lumen)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0035605"(peptidyl-cysteine S-nitrosylase activity)|go:"GO:0035606"(peptidyl-cysteine S-trans-nitrosylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050661"(NADP binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051287"(NAD binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0060359"(response to ammonium ion)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097452"(GAIT complex)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1905460"(negative regulation of vascular associated smooth muscle cell apoptotic process)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006424(Glyceraldehyde-3-phosphate dehydrogenase, type I)|interpro:IPR020828|interpro:IPR020829|interpro:IPR020830|interpro:IPR020831|interpro:IPR036291|mint:P16858|rcsb pdb:6LGJ|rcsb pdb:6LGK|rcsb pdb:6LGM|reactome:R-MMU-70171|reactome:R-MMU-70263|refseq:NP_001276655.1|dip:DIP-31404N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:SkcdXZ+143DDQFioo6mNWNpCLTI10090	intact-crc:F1BE15E3D0506CB2|rigid:u2JH6BptugWobgP2+JCXsN3iGsQ	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q08460	uniprotkb:P84075	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-2128343|uniprotkb:P32076|uniprotkb:P41211|uniprotkb:P70510|uniprotkb:A2A7R4|ensembl:ENSMUSP00000030572|ensembl:ENSMUSP00000093486|ensembl:ENSMUSP00000112143|ensembl:ENSMUSP00000112145|ensembl:ENSMUSP00000119178|ensembl:ENSMUSP00000129548	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:hpca_mouse(display_long)|uniprotkb:Hpca(gene name)|psi-mi:Hpca(display_short)	psi-mi:"MI:0663"(confocal microscopy)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2128440|imex:IM-9475-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_001273010.1|refseq:NP_001273012.1|refseq:XP_011238748.1|refseq:NP_001123891.1|refseq:NP_034601.1|ensembl:ENSMUSG00000028785|refseq:XP_006502838.1|refseq:XP_006502839.1|refseq:XP_006502840.1|ensembl:ENSMUSG00000028785(gene)|ensembl:ENSMUST00000030572(transcript)|ensembl:ENSMUST00000095807(transcript)|ensembl:ENSMUST00000116442(transcript)|ensembl:ENSMUST00000116444(transcript)|ensembl:ENSMUST00000139450(transcript)|ensembl:ENSMUST00000164649(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007420"(brain development)|go:"GO:0010518"(positive regulation of phospholipase activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019900"(kinase binding)|go:"GO:0030424"(axon)|go:"GO:0031283"(negative regulation of guanylate cyclase activity)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0044327"(dendritic spine head)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0048839"(inner ear development)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1901385"(regulation of voltage-gated calcium channel activity)|go:"GO:1901986"(response to ketamine)|go:"GO:1902065"(response to L-glutamate)|go:"GO:1904009"(cellular response to monosodium glutamate)|go:"GO:1904010"(response to Aroclor 1254)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR028846|mint:P84075	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:uqRvTKlr8zMg7+UAfYCSqOljrFc10090	intact-crc:59FC5B61BE263E40|rigid:/vZuXBZsWrL1LDJX77jXe9ih1+U	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q08460	uniprotkb:O88952	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-821316|ensembl:ENSMUSP00000028583	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:lin7c_mouse(display_long)|uniprotkb:Mammalian lin-seven protein 3(gene name synonym)|uniprotkb:Vertebrate lin-7 homolog 3(gene name synonym)|uniprotkb:Veli3(gene name synonym)|uniprotkb:Lin7c(gene name)|psi-mi:Lin7c(display_short)|uniprotkb:Mals3(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2128445|imex:IM-9475-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_035829.1|ensembl:ENSMUSG00000027162(gene)|ensembl:ENSMUST00000028583(transcript)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006887"(exocytosis)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0045202"(synapse)|go:"GO:0097016"(L27 domain binding)|go:"GO:0097025"(MPP7-DLG1-LIN7 complex)|go:"GO:0098793"(presynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903361"(protein localization to basolateral plasma membrane)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR014775(L27, C-terminal)|interpro:IPR017365(Lin-7 homologue)|interpro:IPR036034|interpro:IPR036892|reactome:R-MMU-212676	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3|comment:Proteins colocalise in inner and outer hair cells, and ganglion cells.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:F2rasaJ64Olc9qScN79LJRqsUEE10090	intact-crc:F3B7B1285DB55D86|rigid:1cDdHEaSabdEp2QuY2dQDAHmhEs	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q08460	uniprotkb:P27573	intact:EBI-1633915|uniprotkb:Q64703|uniprotkb:Q8VHF1|uniprotkb:Q9R196	intact:EBI-1634589|uniprotkb:Q542C9	psi-mi:kcma1_mouse(display_long)|uniprotkb:Kcnma1(gene name)|psi-mi:Kcnma1(display_short)|uniprotkb:Kcnma(gene name synonym)|uniprotkb:Calcium-activated potassium channel, subfamily M subunit alpha-1(gene name synonym)|uniprotkb:Maxi K channel(gene name synonym)|uniprotkb:BK channel(gene name synonym)|uniprotkb:"K(VCA)alpha"(gene name synonym)|uniprotkb:BKCA alpha(gene name synonym)|uniprotkb:KCa1.1(gene name synonym)|uniprotkb:Slowpoke homolog(gene name synonym)|uniprotkb:Slo-alpha(gene name synonym)|uniprotkb:Slo1(gene name synonym)	psi-mi:myp0_mouse(display_long)|uniprotkb:Mpz(gene name)|psi-mi:Mpz(display_short)|uniprotkb:P0(gene name synonym)|uniprotkb:Myelin protein zero(gene name synonym)|uniprotkb:Myelin peripheral protein(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Kathiresan et al. (2009)	imex:IM-9475|pubmed:19423573	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2128450|imex:IM-9475-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240294.1|refseq:NP_001240298.1|refseq:NP_034740.2|dip:DIP-42413N|mint:Q08460|go:"GO:0001666"(response to hypoxia)|go:"GO:0003779"(actin binding)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009268"(response to pH)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015269"(calcium-activated potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030425"(dendrite)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032344"(regulation of aldosterone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042311"(vasodilation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045794"(negative regulation of cell volume)|go:"GO:0046541"(saliva secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060072"(large conductance calcium-activated potassium channel activity)|go:"GO:0060073"(micturition)|go:"GO:0060082"(eye blink reflex)|go:"GO:0060083"(smooth muscle contraction involved in micturition)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1904348"(negative regulation of small intestine smooth muscle contraction)|interpro:IPR003929(Potassium channel, calcium-activated, BK, alpha subunit)|interpro:IPR005821(Ion transport)|interpro:IPR024939|interpro:IPR036291|reactome:R-MMU-1296052	refseq:NP_001302428.1|refseq:NP_001302429.1|refseq:NP_032649.2|dip:DIP-51664N|go:"GO:0005764"(lysosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0042552"(myelination)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043209"(myelin sheath)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098743"(cell aggregation)|interpro:IPR000920(Myelin P0 protein)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR019566|interpro:IPR019738|interpro:IPR029869|interpro:IPR036179	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3|comment:Proteins colocalise in inner and outer hair cells, and ganglion cells.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cochlea)|taxid:10090(Mouse cochlea)	-	2008/02/06	2014/10/16	rogid:lUVIPrkYhGQhPzQx4ZPSh0YUw5w10090	rogid:n7Go3hYQ/2jR857QJQnI5GWwqrc10090	intact-crc:00F2A1DFCCEB44D4|rigid:QGOhL2ww11vR4bhrhj4blZNwXRE	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)