#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9V3P0	uniprotkb:P11956	intact:EBI-82319|uniprotkb:Q0KHT0|ensemblmetazoa:FBpp0073594|ensemblmetazoa:FBpp0073595|ensemblmetazoa:FBpp0308756|ensemblmetazoa:FBpp0308757|ensemblmetazoa:FBpp0311371	intact:EBI-88468|uniprotkb:Q1ECC1|uniprotkb:Q9VDM2|ensemblmetazoa:FBpp0083298|ensemblmetazoa:FBpp0311980|ensemblmetazoa:FBpp0311981	psi-mi:prdx1_drome(display_long)|uniprotkb:Jafrac1(gene name)|psi-mi:Jafrac1(display_short)|uniprotkb:Thioredoxin peroxidase(gene name synonym)|uniprotkb:Cytosolic thioredoxin peroxidase(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxiredoxin 1(gene name synonym)|uniprotkb:CG1633(orf name)|uniprotkb:TPX-1(gene name synonym)	psi-mi:mt2_drome(display_long)|uniprotkb:MtnB(gene name)|psi-mi:MtnB(display_short)|uniprotkb:Mto(gene name synonym)|uniprotkb:CG4312(orf name)|uniprotkb:Metallothionein B(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Tio et al. (2009)	imex:IM-9276|pubmed:19343719	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1807597|imex:IM-9276-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_477510.1|refseq:NP_727689.1|flybase:FBgn0040309|ensemblmetazoa:FBgn0040309(gene)|ensemblmetazoa:FBtr0073763(transcript)|ensemblmetazoa:FBtr0073764(transcript)|ensemblmetazoa:FBtr0339699(transcript)|ensemblmetazoa:FBtr0339700(transcript)|ensemblmetazoa:FBtr0345161(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007155"(cell adhesion)|go:"GO:0007281"(germ cell development)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008354"(germ cell migration)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0042594"(response to starvation)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0045321"(leukocyte activation)|go:"GO:0045454"(cell redox homeostasis)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR024706|interpro:IPR036249|reactome:R-DME-3299685|reactome:R-DME-5628897|refseq:NP_001285202.1|refseq:NP_001285203.1|refseq:NP_001285204.1|dip:DIP-17916N	ensemblmetazoa:FBgn0002869(gene)|ensemblmetazoa:FBtr0083890(transcript)|ensemblmetazoa:FBtr0346152(transcript)|ensemblmetazoa:FBtr0346153(transcript)|go:"GO:0005507"(copper ion binding)|go:"GO:0010038"(response to metal ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0055065"(metal ion homeostasis)|interpro:IPR000966(Diptera metallothionein, family 5)|refseq:NP_524413.1|flybase:FBgn0002869|refseq:NP_001287425.1|refseq:NP_001287426.1|dip:DIP-20926N	psi-mi:"MI:0469"(intact)	-	-	comment:MtnB present as Zn�MtnB complex|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/09/08	2014/10/16	rogid:2+JOk/Foml5uctQ9aasQQZ79XZo7227	rogid:qNTIPvObeWGL3Y0lNUz3QXhx9bI7227	intact-crc:FC253555000B1A70|rigid:wjztAT1p4A2UPgeT021dAzObgy4	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P11956	uniprotkb:Q1WWB7	intact:EBI-88468|uniprotkb:Q1ECC1|uniprotkb:Q9VDM2|ensemblmetazoa:FBpp0083298|ensemblmetazoa:FBpp0311980|ensemblmetazoa:FBpp0311981	intact:EBI-130849|intact:EBI-1807603|ensemblmetazoa:FBpp0087138	psi-mi:mt2_drome(display_long)|uniprotkb:MtnB(gene name)|psi-mi:MtnB(display_short)|uniprotkb:Mto(gene name synonym)|uniprotkb:CG4312(orf name)|uniprotkb:Metallothionein B(gene name synonym)	psi-mi:q1wwb7_drome(display_long)|uniprotkb:betaG(gene name)|psi-mi:betaG(display_short)|uniprotkb:Dmel\CG13192(gene name synonym)|uniprotkb:CG13192(orf name)|uniprotkb:Dmel_CG13192(orf name)	psi-mi:"MI:0018"(two hybrid)	Tio et al. (2009)	imex:IM-9276|pubmed:19343719	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1807611|imex:IM-9276-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:FBgn0002869(gene)|ensemblmetazoa:FBtr0083890(transcript)|ensemblmetazoa:FBtr0346152(transcript)|ensemblmetazoa:FBtr0346153(transcript)|go:"GO:0005507"(copper ion binding)|go:"GO:0010038"(response to metal ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0055065"(metal ion homeostasis)|interpro:IPR000966(Diptera metallothionein, family 5)|refseq:NP_524413.1|flybase:FBgn0002869|refseq:NP_001287425.1|refseq:NP_001287426.1|dip:DIP-20926N	refseq:NP_610702.1|flybase:FBgn0033653|ensemblmetazoa:FBgn0033653(gene)|ensemblmetazoa:FBtr0088031(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0035176"(social behavior)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322	psi-mi:"MI:0469"(intact)	-	-	comment:MtnB present as Zn�MtnB complex|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/09/08	2014/10/16	rogid:qNTIPvObeWGL3Y0lNUz3QXhx9bI7227	rogid:TmnmaKwG/8NVfqcbQsK3Hfw+scM7227	intact-crc:D1BA328D7F2B2159|rigid:Vb5RCgwZGJyX3atGmo44hymQLW0	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P11956	uniprotkb:Q9W4P5	intact:EBI-88468|uniprotkb:Q1ECC1|uniprotkb:Q9VDM2|ensemblmetazoa:FBpp0083298|ensemblmetazoa:FBpp0311980|ensemblmetazoa:FBpp0311981	intact:EBI-179683|ensemblmetazoa:FBpp0070584	psi-mi:mt2_drome(display_long)|uniprotkb:MtnB(gene name)|psi-mi:MtnB(display_short)|uniprotkb:Mto(gene name synonym)|uniprotkb:CG4312(orf name)|uniprotkb:Metallothionein B(gene name synonym)	psi-mi:va0d1_drome(display_long)|uniprotkb:VhaAC39-1(gene name)|psi-mi:VhaAC39-1(display_short)|uniprotkb:CG2934(orf name)|uniprotkb:Vacuolar proton pump subunit d 1(gene name synonym)|uniprotkb:V-ATPase 39 kDa subunit(gene name synonym)|uniprotkb:VhaAC39(gene name synonym)|uniprotkb:Vacuolar H+ ATPase subunit AC39-1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Tio et al. (2009)	imex:IM-9276|pubmed:19343719	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2320343|imex:IM-9276-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:FBgn0002869(gene)|ensemblmetazoa:FBtr0083890(transcript)|ensemblmetazoa:FBtr0346152(transcript)|ensemblmetazoa:FBtr0346153(transcript)|go:"GO:0005507"(copper ion binding)|go:"GO:0010038"(response to metal ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0055065"(metal ion homeostasis)|interpro:IPR000966(Diptera metallothionein, family 5)|refseq:NP_524413.1|flybase:FBgn0002869|refseq:NP_001287425.1|refseq:NP_001287426.1|dip:DIP-20926N	refseq:NP_570080.1|flybase:FBgn0285910|dip:DIP-18121N|reactome:R-DME-917977|reactome:R-DME-9639288|reactome:R-DME-983712|ensemblmetazoa:FBgn0285910(gene)|ensemblmetazoa:FBtr0070611(transcript)|go:"GO:0000220"(vacuolar proton-transporting V-type ATPase, V0 domain)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007034"(vacuolar transport)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0033181"(plasma membrane proton-transporting V-type ATPase complex)|go:"GO:0036295"(cellular response to increased oxygen levels)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR002843(ATPase, V0/A0 complex, subunit C/D)|interpro:IPR016727(ATPase, V0 complex, subunit D)|interpro:IPR035067|interpro:IPR036079|interpro:IPR044911|reactome:R-DME-1222556|reactome:R-DME-77387	psi-mi:"MI:0469"(intact)	-	-	comment:MtnB present as Zn�MtnB complex|caution:Attempts to verify this interaction by GST pulldown failed as VhaAC39 also interacted with nonfused GST. Sequencing of the corresponding clones revealed nonframe fusions, led the authors to consider it to be a false positive.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/09/08	2014/10/16	rogid:qNTIPvObeWGL3Y0lNUz3QXhx9bI7227	rogid:BazTrmDqReflnP5U0R4r0+SkpoA7227	intact-crc:1893186C73A6BBF9|rigid:gno10ilzC/NRN2WDJjqYoBOxq5o	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q1WWB7	uniprotkb:P11956	intact:EBI-130849|intact:EBI-1807603|ensemblmetazoa:FBpp0087138	intact:EBI-88468|uniprotkb:Q1ECC1|uniprotkb:Q9VDM2|ensemblmetazoa:FBpp0083298|ensemblmetazoa:FBpp0311980|ensemblmetazoa:FBpp0311981	psi-mi:q1wwb7_drome(display_long)|uniprotkb:betaG(gene name)|psi-mi:betaG(display_short)|uniprotkb:Dmel\CG13192(gene name synonym)|uniprotkb:CG13192(orf name)|uniprotkb:Dmel_CG13192(orf name)	psi-mi:mt2_drome(display_long)|uniprotkb:MtnB(gene name)|psi-mi:MtnB(display_short)|uniprotkb:Mto(gene name synonym)|uniprotkb:CG4312(orf name)|uniprotkb:Metallothionein B(gene name synonym)	psi-mi:"MI:0096"(pull down)	Tio et al. (2009)	imex:IM-9276|pubmed:19343719	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1807620|imex:IM-9276-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_610702.1|flybase:FBgn0033653|ensemblmetazoa:FBgn0033653(gene)|ensemblmetazoa:FBtr0088031(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0035176"(social behavior)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322	ensemblmetazoa:FBgn0002869(gene)|ensemblmetazoa:FBtr0083890(transcript)|ensemblmetazoa:FBtr0346152(transcript)|ensemblmetazoa:FBtr0346153(transcript)|go:"GO:0005507"(copper ion binding)|go:"GO:0010038"(response to metal ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0055065"(metal ion homeostasis)|interpro:IPR000966(Diptera metallothionein, family 5)|refseq:NP_524413.1|flybase:FBgn0002869|refseq:NP_001287425.1|refseq:NP_001287426.1|dip:DIP-20926N	psi-mi:"MI:0469"(intact)	-	-	figure legend:1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/09/08	2014/10/16	rogid:TmnmaKwG/8NVfqcbQsK3Hfw+scM7227	rogid:qNTIPvObeWGL3Y0lNUz3QXhx9bI7227	intact-crc:967B8D12403F7372|rigid:Vb5RCgwZGJyX3atGmo44hymQLW0	false	-	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P11956	uniprotkb:Q9V3P0	intact:EBI-88468|uniprotkb:Q1ECC1|uniprotkb:Q9VDM2|ensemblmetazoa:FBpp0083298|ensemblmetazoa:FBpp0311980|ensemblmetazoa:FBpp0311981	intact:EBI-82319|uniprotkb:Q0KHT0|ensemblmetazoa:FBpp0073594|ensemblmetazoa:FBpp0073595|ensemblmetazoa:FBpp0308756|ensemblmetazoa:FBpp0308757|ensemblmetazoa:FBpp0311371	psi-mi:mt2_drome(display_long)|uniprotkb:MtnB(gene name)|psi-mi:MtnB(display_short)|uniprotkb:Mto(gene name synonym)|uniprotkb:CG4312(orf name)|uniprotkb:Metallothionein B(gene name synonym)	psi-mi:prdx1_drome(display_long)|uniprotkb:Jafrac1(gene name)|psi-mi:Jafrac1(display_short)|uniprotkb:Thioredoxin peroxidase(gene name synonym)|uniprotkb:Cytosolic thioredoxin peroxidase(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxiredoxin 1(gene name synonym)|uniprotkb:CG1633(orf name)|uniprotkb:TPX-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Tio et al. (2009)	imex:IM-9276|pubmed:19343719	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1807626|imex:IM-9276-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:FBgn0002869(gene)|ensemblmetazoa:FBtr0083890(transcript)|ensemblmetazoa:FBtr0346152(transcript)|ensemblmetazoa:FBtr0346153(transcript)|go:"GO:0005507"(copper ion binding)|go:"GO:0010038"(response to metal ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0055065"(metal ion homeostasis)|interpro:IPR000966(Diptera metallothionein, family 5)|refseq:NP_524413.1|flybase:FBgn0002869|refseq:NP_001287425.1|refseq:NP_001287426.1|dip:DIP-20926N	refseq:NP_477510.1|refseq:NP_727689.1|flybase:FBgn0040309|ensemblmetazoa:FBgn0040309(gene)|ensemblmetazoa:FBtr0073763(transcript)|ensemblmetazoa:FBtr0073764(transcript)|ensemblmetazoa:FBtr0339699(transcript)|ensemblmetazoa:FBtr0339700(transcript)|ensemblmetazoa:FBtr0345161(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007155"(cell adhesion)|go:"GO:0007281"(germ cell development)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008354"(germ cell migration)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0042594"(response to starvation)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0045321"(leukocyte activation)|go:"GO:0045454"(cell redox homeostasis)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR024706|interpro:IPR036249|reactome:R-DME-3299685|reactome:R-DME-5628897|refseq:NP_001285202.1|refseq:NP_001285203.1|refseq:NP_001285204.1|dip:DIP-17916N	psi-mi:"MI:0469"(intact)	-	-	comment:Interaction occurs when MtnB complexed with Zn ions or in the absence of metal complexing but not when complexed with Cu ions. the presence  of copper ions in solution weakens or even abolishes the Zn�MT/Jafrac1 interaction.|figure legend:Figs. 1, 2C and 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/09/08	2014/10/16	rogid:qNTIPvObeWGL3Y0lNUz3QXhx9bI7227	rogid:2+JOk/Foml5uctQ9aasQQZ79XZo7227	intact-crc:4B0BA481DC253C88|rigid:wjztAT1p4A2UPgeT021dAzObgy4	false	glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P04357	uniprotkb:Q9V3P0	intact:EBI-172200|uniprotkb:Q9VH67|uniprotkb:B5T1U3|uniprotkb:B5T1U5|ensemblmetazoa:FBpp0081636|ensemblmetazoa:FBpp0306744	intact:EBI-82319|uniprotkb:Q0KHT0|ensemblmetazoa:FBpp0073594|ensemblmetazoa:FBpp0073595|ensemblmetazoa:FBpp0308756|ensemblmetazoa:FBpp0308757|ensemblmetazoa:FBpp0311371	psi-mi:mt1_drome(display_long)|uniprotkb:MtnA(gene name)|psi-mi:MtnA(display_short)|uniprotkb:CG9470(orf name)	psi-mi:prdx1_drome(display_long)|uniprotkb:Jafrac1(gene name)|psi-mi:Jafrac1(display_short)|uniprotkb:Thioredoxin peroxidase(gene name synonym)|uniprotkb:Cytosolic thioredoxin peroxidase(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxiredoxin 1(gene name synonym)|uniprotkb:CG1633(orf name)|uniprotkb:TPX-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Tio et al. (2009)	imex:IM-9276|pubmed:19343719	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1807673|imex:IM-9276-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_524299.1|flybase:FBgn0002868|refseq:NP_001262438.1|dip:DIP-19543N|ensemblmetazoa:FBgn0002868(gene)|ensemblmetazoa:FBtr0082158(transcript)|ensemblmetazoa:FBtr0334686(transcript)|go:"GO:0010038"(response to metal ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0055065"(metal ion homeostasis)|interpro:IPR000966(Diptera metallothionein, family 5)	refseq:NP_477510.1|refseq:NP_727689.1|flybase:FBgn0040309|ensemblmetazoa:FBgn0040309(gene)|ensemblmetazoa:FBtr0073763(transcript)|ensemblmetazoa:FBtr0073764(transcript)|ensemblmetazoa:FBtr0339699(transcript)|ensemblmetazoa:FBtr0339700(transcript)|ensemblmetazoa:FBtr0345161(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007155"(cell adhesion)|go:"GO:0007281"(germ cell development)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008354"(germ cell migration)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0042594"(response to starvation)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0045321"(leukocyte activation)|go:"GO:0045454"(cell redox homeostasis)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR024706|interpro:IPR036249|reactome:R-DME-3299685|reactome:R-DME-5628897|refseq:NP_001285202.1|refseq:NP_001285203.1|refseq:NP_001285204.1|dip:DIP-17916N	psi-mi:"MI:0469"(intact)	-	-	comment:Interaction occurs when MtnA complexed with Zn ions or in the absence of metal complexing but not when complexed with Cu ions. The presence  of copper ions in solution weakens or even abolishes the Zn�MT/Jafrac1 interaction|figure legend:Figs 1, 2C and 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/09/08	2014/10/16	rogid:BTzw/q9yHjxONTyp5+CuTO7p4/07227	rogid:2+JOk/Foml5uctQ9aasQQZ79XZo7227	intact-crc:85A37CA19DB4C856|rigid:wN4WCWrO5sQPIWWxxpq9Qk5to7c	false	glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P41902	uniprotkb:P34760	intact:EBI-5162|uniprotkb:D6W296	intact:EBI-19623|uniprotkb:D6VZE6|ensemblfungi:YML028W	psi-mi:crs5_yeast(display_long)|uniprotkb:CRS5(gene name)|psi-mi:CRS5(display_short)|uniprotkb:O2675(orf name)|uniprotkb:YOR031W(locus name)	psi-mi:tsa1_yeast(display_long)|uniprotkb:TSA1(gene name)|psi-mi:TSA1(display_short)|uniprotkb:TPX1(gene name synonym)|uniprotkb:TSA(gene name synonym)|uniprotkb:YML028W(locus name)|uniprotkb:Cytoplasmic thiol peroxidase 1(gene name synonym)|uniprotkb:Thiol-specific antioxidant protein 1(gene name synonym)|uniprotkb:ZRG14(gene name synonym)|uniprotkb:Protector protein(gene name synonym)|uniprotkb:Thioredoxin peroxidase type Ia(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxide reductase(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxiredoxin TSA1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Tio et al. (2009)	imex:IM-9276|pubmed:19343719	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1807736|imex:IM-9276-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000005557|dip:DIP-5511N|go:"GO:0005507"(copper ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0010038"(response to metal ion)|interpro:IPR035715	refseq:NP_013684.1|sgd:S000004490|ensemblfungi:YML028W(gene)|ensemblfungi:YML028W_mRNA(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006457"(protein folding)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0019207"(kinase regulator activity)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042262"(DNA protection)|go:"GO:0042802"(identical protein binding)|go:"GO:0043022"(ribosome binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051258"(protein polymerization)|go:"GO:0051920"(peroxiredoxin activity)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0071447"(cellular response to hydroperoxide)|go:"GO:0090344"(negative regulation of cell aging)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR024706|interpro:IPR036249|rcsb pdb:3SBC|reactome:R-SCE-5628897|reactome:R-SCE-6798695|dip:DIP-1667N|mint:P34760	psi-mi:"MI:0469"(intact)	-	crc64:9ACF40E410F2C04A	comment:Interaction occurred when CRS5 complexed with both copper and zinc ions however Crs5p complexes synthesized in Cu-supplemented  cultures most probably consist of heterometallic Zn, Cu-species.|figure legend:Fig. 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/09/08	2014/10/16	rogid:j4oJEwGSOVJeLFRydjF0k9ASq14559292	rogid:2kHGj9RnAcSVt34pqwssv9nANPM559292	intact-crc:E6042076121391B4|rigid:uByNJjobX2WepbjkcoRYb84kvfU	false	-	his tag:?-?	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q04120	uniprotkb:P41902	intact:EBI-19631|uniprotkb:D6VT78|ensemblfungi:YDR453C	intact:EBI-5162|uniprotkb:D6W296	psi-mi:tsa2_yeast(display_long)|uniprotkb:TSA2(gene name)|psi-mi:TSA2(display_short)|uniprotkb:Cytoplasmic thiol peroxidase 2(gene name synonym)|uniprotkb:Thiol-specific antioxidant protein 2(gene name synonym)|uniprotkb:Thioredoxin peroxidase type Ib(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxiredoxin TSA2(gene name synonym)|uniprotkb:D9461.38(orf name)|uniprotkb:YDR453C(locus name)	psi-mi:crs5_yeast(display_long)|uniprotkb:CRS5(gene name)|psi-mi:CRS5(display_short)|uniprotkb:O2675(orf name)|uniprotkb:YOR031W(locus name)	psi-mi:"MI:0096"(pull down)	Tio et al. (2009)	imex:IM-9276|pubmed:19343719	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1807741|imex:IM-9276-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010741.1|sgd:S000002861|ensemblfungi:YDR453C(gene)|ensemblfungi:YDR453C_mRNA(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051920"(peroxiredoxin activity)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR024706|interpro:IPR036249|rcsb pdb:5DVB|rcsb pdb:6UTL|reactome:R-SCE-5628897|rcsb pdb:5EPT|dip:DIP-4317N|mint:Q04120	sgd:S000005557|dip:DIP-5511N|go:"GO:0005507"(copper ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0010038"(response to metal ion)|interpro:IPR035715	psi-mi:"MI:0469"(intact)	crc64:43CC57C92081D745	-	comment:Interaction occurred when CRS5 complexed with both copper and zinc ions however Crs5p complexes synthesized in Cu-supplemented cultures most probably consist of heterometallic Zn, Cu-species.|figure legend:Fig. 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/09/08	2014/10/16	rogid:EAvk8fI2JOPylqetDAzROxC+7hQ559292	rogid:j4oJEwGSOVJeLFRydjF0k9ASq14559292	intact-crc:4ADAC1A1D467A78F|rigid:xsGDXfbvD+gASDTm8fvhbPnneLE	false	his tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)