#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q86Z14	uniprotkb:Q9NSA1	intact:EBI-8515198|uniprotkb:Q2M3K8|intact:MINT-6799890|ensembl:ENSP00000257408	intact:EBI-3909329|uniprotkb:Q8N683|ensembl:ENSP00000222157|ensembl:ENSP00000471477	psi-mi:klotb_human(display_long)|uniprotkb:KLB(gene name)|psi-mi:KLB(display_short)|uniprotkb:Klotho beta-like protein(gene name synonym)	psi-mi:fgf21_human(display_long)|uniprotkb:FGF21(gene name)|psi-mi:FGF21(display_short)|uniprotkb:UNQ3115/PRO10196(orf name)	psi-mi:"MI:0107"(surface plasmon resonance)	Yie et al. (2009)	mint:MINT-6799868|pubmed:19059246|imex:IM-15863|doi:10.1016/j.febslet.2008.11.023|mint:d-08-01830	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8515192|mint:MINT-6799907|imex:IM-15863-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_783864.1|ensembl:ENSG00000134962(gene)|ensembl:ENST00000257408(transcript)|go:"GO:0004553"(hydrolase activity, hydrolyzing O-glycosyl compounds)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0090080"(positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway)|interpro:IPR001360(Glycoside hydrolase, family 1)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|mint:Q86Z14|rcsb pdb:5VAK|rcsb pdb:5VAN|rcsb pdb:5VAQ|rcsb pdb:5WI9|rcsb pdb:6NFJ|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1307965|reactome:R-HSA-2219530|reactome:R-HSA-5654228|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654733|reactome:R-HSA-5673001|reactome:R-HSA-6811558|mint:MINT-6799910(identity)	refseq:NP_061986.1|ensembl:ENSG00000105550(gene)|ensembl:ENST00000222157(transcript)|ensembl:ENST00000593756(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010898"(positive regulation of triglyceride catabolic process)|go:"GO:0010988"(regulation of low-density lipoprotein particle clearance)|go:"GO:0014823"(response to activity)|go:"GO:0030154"(cell differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0035690"|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071377"(cellular response to glucagon stimulus)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0090080"(positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1904640"(response to methionine)|go:"GO:1905599"(positive regulation of low-density lipoprotein receptor activity)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR002209(Heparin-binding growth factor/Fibroblast growth factor)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR028292|interpro:IPR035444|mint:Q9NSA1|rcsb pdb:5VAQ|rcsb pdb:6M6E|rcsb pdb:6M6F|reactome:R-HSA-189200|reactome:R-HSA-8963889|go:"GO:0072577"(endothelial cell apoptotic process)|mint:MINT-6799909(identity)	-	function:"Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21"|comment:mint	-	figure legend:F1D|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/11/13	2014/10/16	rogid:7IlmCs2NHDZNUZNq2KroRIqeDLY9606	rogid:ZE2K8sYL11qZN3Me0FTU77K/GC09606	intact-crc:D7E46B51B5A6D213|rigid:brFYiFvHhl4EuV7GYv6oapdfjTs	false	binding-associated region:1-992(MINT-6799919)|his tag:?-?(MINT-6799916)	biotin tag:?-?(MINT-6799912)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q86Z14	uniprotkb:Q9NSA1	intact:EBI-8515198|uniprotkb:Q2M3K8|intact:MINT-6799890|ensembl:ENSP00000257408	intact:EBI-3909329|uniprotkb:Q8N683|ensembl:ENSP00000222157|ensembl:ENSP00000471477	psi-mi:klotb_human(display_long)|uniprotkb:KLB(gene name)|psi-mi:KLB(display_short)|uniprotkb:Klotho beta-like protein(gene name synonym)	psi-mi:fgf21_human(display_long)|uniprotkb:FGF21(gene name)|psi-mi:FGF21(display_short)|uniprotkb:UNQ3115/PRO10196(orf name)	psi-mi:"MI:0107"(surface plasmon resonance)	Yie et al. (2009)	mint:MINT-6799868|pubmed:19059246|imex:IM-15863|doi:10.1016/j.febslet.2008.11.023|mint:d-08-01830	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8515245|mint:MINT-6799922|imex:IM-15863-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_783864.1|ensembl:ENSG00000134962(gene)|ensembl:ENST00000257408(transcript)|go:"GO:0004553"(hydrolase activity, hydrolyzing O-glycosyl compounds)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0090080"(positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway)|interpro:IPR001360(Glycoside hydrolase, family 1)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|mint:Q86Z14|rcsb pdb:5VAK|rcsb pdb:5VAN|rcsb pdb:5VAQ|rcsb pdb:5WI9|rcsb pdb:6NFJ|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1307965|reactome:R-HSA-2219530|reactome:R-HSA-5654228|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654733|reactome:R-HSA-5673001|reactome:R-HSA-6811558|mint:MINT-6799924(identity)	refseq:NP_061986.1|ensembl:ENSG00000105550(gene)|ensembl:ENST00000222157(transcript)|ensembl:ENST00000593756(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010898"(positive regulation of triglyceride catabolic process)|go:"GO:0010988"(regulation of low-density lipoprotein particle clearance)|go:"GO:0014823"(response to activity)|go:"GO:0030154"(cell differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0035690"|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071377"(cellular response to glucagon stimulus)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0090080"(positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1904640"(response to methionine)|go:"GO:1905599"(positive regulation of low-density lipoprotein receptor activity)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR002209(Heparin-binding growth factor/Fibroblast growth factor)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR028292|interpro:IPR035444|mint:Q9NSA1|rcsb pdb:5VAQ|rcsb pdb:6M6E|rcsb pdb:6M6F|reactome:R-HSA-189200|reactome:R-HSA-8963889|go:"GO:0072577"(endothelial cell apoptotic process)|mint:MINT-6799930(identity)	-	function:"Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21"|comment:mint	-	figure legend:F2B|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/11/13	2014/10/16	rogid:7IlmCs2NHDZNUZNq2KroRIqeDLY9606	rogid:ZE2K8sYL11qZN3Me0FTU77K/GC09606	intact-crc:EBE4E11676026EB8|rigid:brFYiFvHhl4EuV7GYv6oapdfjTs	false	binding-associated region:1-992(MINT-6799925)|his tag:?-?(MINT-6799927)	mutation decreasing interaction:168-181(MINT-6800347)|biotin tag:?-?(MINT-6799931)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q86Z14	uniprotkb:P11362	intact:EBI-8515198|uniprotkb:Q2M3K8|intact:MINT-6799890|ensembl:ENSP00000257408	intact:EBI-1028277|uniprotkb:P17049|uniprotkb:Q02063|uniprotkb:Q02065|uniprotkb:Q14306|uniprotkb:Q14307|uniprotkb:Q8N685|uniprotkb:C1KBH8|uniprotkb:Q9UDF0|uniprotkb:Q9UDF1|uniprotkb:Q9UDF2|uniprotkb:Q59H40|uniprotkb:Q5BJG2|uniprotkb:A8K6T9|uniprotkb:A8K8V5|uniprotkb:Q53H63|uniprotkb:Q9UD50|intact:EBI-1058611|ensembl:ENSP00000400162	psi-mi:klotb_human(display_long)|uniprotkb:KLB(gene name)|psi-mi:KLB(display_short)|uniprotkb:Klotho beta-like protein(gene name synonym)	psi-mi:fgfr1_human(display_long)|uniprotkb:FGFR1(gene name)|psi-mi:FGFR1(display_short)|uniprotkb:FGFBR(gene name synonym)|uniprotkb:FLG(gene name synonym)|uniprotkb:FLT2(gene name synonym)|uniprotkb:Fms-like tyrosine kinase 2(gene name synonym)|uniprotkb:Proto-oncogene c-Fgr(gene name synonym)|uniprotkb:BFGFR(gene name synonym)|uniprotkb:CEK(gene name synonym)|uniprotkb:HBGFR(gene name synonym)|uniprotkb:Basic fibroblast growth factor receptor 1(gene name synonym)|uniprotkb:N-sam(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Yie et al. (2009)	mint:MINT-6799868|pubmed:19059246|imex:IM-15863|doi:10.1016/j.febslet.2008.11.023|mint:d-08-01830	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8515318|mint:MINT-6799939|imex:IM-15863-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_783864.1|ensembl:ENSG00000134962(gene)|ensembl:ENST00000257408(transcript)|go:"GO:0004553"(hydrolase activity, hydrolyzing O-glycosyl compounds)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0090080"(positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway)|interpro:IPR001360(Glycoside hydrolase, family 1)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|mint:Q86Z14|rcsb pdb:5VAK|rcsb pdb:5VAN|rcsb pdb:5VAQ|rcsb pdb:5WI9|rcsb pdb:6NFJ|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1307965|reactome:R-HSA-2219530|reactome:R-HSA-5654228|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654733|reactome:R-HSA-5673001|reactome:R-HSA-6811558|mint:MINT-6799947(identity)	refseq:NP_001167534.1|refseq:NP_001167535.1|refseq:NP_001167536.1|refseq:NP_001167537.1|refseq:NP_001167538.1|refseq:NP_056934.2|refseq:NP_075593.1|refseq:NP_075594.1|refseq:NP_075598.2|ensembl:ENSG00000077782(gene)|ensembl:ENST00000447712(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001501"(skeletal system development)|go:"GO:0001764"(neuron migration)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005007"(fibroblast growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0010518"(positive regulation of phospholipase activity)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043009"(chordate embryonic development)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0090722"(receptor-receptor interaction)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000546"(positive regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2001239"(regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016248(Fibroblast growth factor receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR028174|interpro:IPR036179|interpro:IPR041159|mint:P11362|rcsb pdb:1AGW|rcsb pdb:1CVS|rcsb pdb:1EVT|rcsb pdb:1FGI|rcsb pdb:1FGK|rcsb pdb:1FQ9|go:"GO:0045666"(positive regulation of neuron differentiation)|rcsb pdb:1XR0|rcsb pdb:2CR3|rcsb pdb:2FGI|rcsb pdb:3C4F|rcsb pdb:3DPK|rcsb pdb:3GQI|rcsb pdb:3GQL|rcsb pdb:3JS2|rcsb pdb:3KRJ|rcsb pdb:3KRL|rcsb pdb:3KXX|rcsb pdb:3KY2|rcsb pdb:3OJV|rcsb pdb:3RHX|rcsb pdb:3TT0|rcsb pdb:4F63|rcsb pdb:4F64|rcsb pdb:4F65|rcsb pdb:4NK9|rcsb pdb:4NKA|rcsb pdb:4NKS|rcsb pdb:4RWI|rcsb pdb:4RWJ|rcsb pdb:4RWK|rcsb pdb:4RWL|rcsb pdb:4UWC|rcsb pdb:4UWY|rcsb pdb:4V01|rcsb pdb:4V04|rcsb pdb:4V05|rcsb pdb:4WUN|rcsb pdb:4ZSA|rcsb pdb:5A46|rcsb pdb:5A4C|rcsb pdb:5AM6|rcsb pdb:5AM7|rcsb pdb:5B7V|rcsb pdb:5EW8|rcsb pdb:5FLF|rcsb pdb:5O49|rcsb pdb:5O4A|rcsb pdb:5UQ0|rcsb pdb:5UR1|rcsb pdb:5VND|rcsb pdb:5W21|rcsb pdb:5W59|rcsb pdb:5Z0S|rcsb pdb:5ZV2|rcsb pdb:6C18|rcsb pdb:6C19|rcsb pdb:6C1B|rcsb pdb:6C1C|rcsb pdb:6C1O|rcsb pdb:6ITJ|rcsb pdb:6MZQ|rcsb pdb:6MZW|rcsb pdb:6NVL|rcsb pdb:6P68|rcsb pdb:6P69|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1839120|rcsb pdb:4UWB|reactome:R-HSA-1839122|reactome:R-HSA-190370|reactome:R-HSA-190373|reactome:R-HSA-190374|reactome:R-HSA-2219530|reactome:R-HSA-375165|reactome:R-HSA-445144|reactome:R-HSA-5654219|reactome:R-HSA-5654687|reactome:R-HSA-5654688|reactome:R-HSA-5654689|reactome:R-HSA-5654693|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8853336|reactome:R-HSA-5654726|dip:DIP-4019N|mint:MINT-6799941(identity)	-	function:"Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21"|comment:mint	-	figure legend:F1E|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/11/13	2014/10/16	rogid:7IlmCs2NHDZNUZNq2KroRIqeDLY9606	rogid:th/BEfNYh60oKK7G0HFX+O1pXh89606	intact-crc:B1BD98FBC1486DFF|rigid:UTojmD45gtpl27F6uoZUEHFeM0I	false	his tag:?-?(MINT-6799948)|binding-associated region:1-992(MINT-6799950)	biotin tag:?-?(MINT-6799944)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)