#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:O14543 uniprotkb:Q66K74 intact:EBI-714146|uniprotkb:O14509|ensembl:ENSP00000330341 intact:EBI-2133734|uniprotkb:Q8N3W5|uniprotkb:Q8NI88|uniprotkb:Q8N3L8|uniprotkb:Q27QB1|uniprotkb:Q96H94|uniprotkb:Q96IT4|uniprotkb:Q96SP8|uniprotkb:Q9BRC6|uniprotkb:Q9H928|uniprotkb:Q9NVK7|uniprotkb:Q6NXF1|ensembl:ENSP00000325313|intact:EBI-2556419|intact:EBI-10978604|uniprotkb:B4DH53|intact:EBI-28978421 psi-mi:socs3_human(display_long)|uniprotkb:Cytokine-inducible SH2 protein 3(gene name synonym)|uniprotkb:STAT-induced STAT inhibitor 3(gene name synonym)|uniprotkb:SOCS3(gene name)|psi-mi:SOCS3(display_short)|uniprotkb:CIS3(gene name synonym)|uniprotkb:SSI3(gene name synonym) psi-mi:map1s_human(display_long)|uniprotkb:MAP1S(gene name)|psi-mi:MAP1S(display_short)|uniprotkb:BPY2IP1(gene name synonym)|uniprotkb:C19orf5(gene name synonym)|uniprotkb:MAP8(gene name synonym)|uniprotkb:VCY2IP1(gene name synonym)|uniprotkb:BPY2-interacting protein 1(gene name synonym)|uniprotkb:Microtubule-associated protein 8(gene name synonym)|uniprotkb:Variable charge Y chromosome 2-interacting protein 1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Zou et al. (2008) mint:MINT-6796846|pubmed:19027008|imex:IM-9592|doi:10.1016/j.febslet.2008.10.055|mint:d-08-01699 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8506217|mint:MINT-6796936|imex:IM-9592-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0060708"(spongiotrophoblast differentiation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR028414|interpro:IPR035863|interpro:IPR036036|interpro:IPR036860|mint:O14543|reactome:R-HSA-1059683|reactome:R-HSA-2586552|reactome:R-HSA-6785807|reactome:R-HSA-877300|reactome:R-HSA-877312|reactome:R-HSA-8849474|reactome:R-HSA-8939242|reactome:R-HSA-8951664|reactome:R-HSA-909733|reactome:R-HSA-912694|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-983168|go:"GO:0050728"(negative regulation of inflammatory response)|ensembl:ENSG00000184557(gene)|ensembl:ENST00000330871(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|refseq:NP_003946.3|mint:MINT-6796938(identity) ensembl:ENSG00000130479(gene)|ensembl:ENST00000324096(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007409"(axonogenesis)|refseq:NP_001295292.1|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0010848"(regulation of chromatin disassembly)|go:"GO:0015631"(tubulin binding)|go:"GO:0016358"(dendrite development)|go:"GO:0030054"(cell junction)|go:"GO:0030425"(dendrite)|go:"GO:0031114"(regulation of microtubule depolymerization)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051015"(actin filament binding)|interpro:IPR026074|ensembl:ENSP00000325313|ensembl:ENST00000544059|ensembl:ENSP00000439243|refseq:NP_060644.4|interpro:IPR027322|mint:Q66K74|mint:MINT-6796942(identity) - - - figure legend:F2A|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2008/11/05 2014/10/16 rogid:8HnU9EL52BGdud2WFZwYsv5R22I9606 rogid:f+UnRFHFEFKp2fTRCHt4/HXtnFQ9606 intact-crc:450BDAFFD0B60552|rigid:0RSOzMCHb/g+/oq4DFqtfxk4dow false tag:?-?(MINT-6796939)|binding-associated region:164-185(MINT-6796951) tag:?-?(MINT-6796943) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O14543 uniprotkb:Q66K74 intact:EBI-714146|uniprotkb:O14509|ensembl:ENSP00000330341 intact:EBI-2133734|uniprotkb:Q8N3W5|uniprotkb:Q8NI88|uniprotkb:Q8N3L8|uniprotkb:Q27QB1|uniprotkb:Q96H94|uniprotkb:Q96IT4|uniprotkb:Q96SP8|uniprotkb:Q9BRC6|uniprotkb:Q9H928|uniprotkb:Q9NVK7|uniprotkb:Q6NXF1|ensembl:ENSP00000325313|intact:EBI-2556419|intact:EBI-10978604|uniprotkb:B4DH53|intact:EBI-28978421 psi-mi:socs3_human(display_long)|uniprotkb:Cytokine-inducible SH2 protein 3(gene name synonym)|uniprotkb:STAT-induced STAT inhibitor 3(gene name synonym)|uniprotkb:SOCS3(gene name)|psi-mi:SOCS3(display_short)|uniprotkb:CIS3(gene name synonym)|uniprotkb:SSI3(gene name synonym) psi-mi:map1s_human(display_long)|uniprotkb:MAP1S(gene name)|psi-mi:MAP1S(display_short)|uniprotkb:BPY2IP1(gene name synonym)|uniprotkb:C19orf5(gene name synonym)|uniprotkb:MAP8(gene name synonym)|uniprotkb:VCY2IP1(gene name synonym)|uniprotkb:BPY2-interacting protein 1(gene name synonym)|uniprotkb:Microtubule-associated protein 8(gene name synonym)|uniprotkb:Variable charge Y chromosome 2-interacting protein 1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Zou et al. (2008) mint:MINT-6796846|pubmed:19027008|imex:IM-9592|doi:10.1016/j.febslet.2008.10.055|mint:d-08-01699 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8506173|mint:MINT-6796875|imex:IM-9592-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0060708"(spongiotrophoblast differentiation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR028414|interpro:IPR035863|interpro:IPR036036|interpro:IPR036860|mint:O14543|reactome:R-HSA-1059683|reactome:R-HSA-2586552|reactome:R-HSA-6785807|reactome:R-HSA-877300|reactome:R-HSA-877312|reactome:R-HSA-8849474|reactome:R-HSA-8939242|reactome:R-HSA-8951664|reactome:R-HSA-909733|reactome:R-HSA-912694|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-983168|go:"GO:0050728"(negative regulation of inflammatory response)|ensembl:ENSG00000184557(gene)|ensembl:ENST00000330871(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|refseq:NP_003946.3|mint:MINT-6796877(identity) ensembl:ENSG00000130479(gene)|ensembl:ENST00000324096(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007409"(axonogenesis)|refseq:NP_001295292.1|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0010848"(regulation of chromatin disassembly)|go:"GO:0015631"(tubulin binding)|go:"GO:0016358"(dendrite development)|go:"GO:0030054"(cell junction)|go:"GO:0030425"(dendrite)|go:"GO:0031114"(regulation of microtubule depolymerization)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051015"(actin filament binding)|interpro:IPR026074|ensembl:ENSP00000325313|ensembl:ENST00000544059|ensembl:ENSP00000439243|refseq:NP_060644.4|interpro:IPR027322|mint:Q66K74|mint:MINT-6796878(identity) - - - figure legend:F1A|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2008/11/05 2014/10/16 rogid:8HnU9EL52BGdud2WFZwYsv5R22I9606 rogid:f+UnRFHFEFKp2fTRCHt4/HXtnFQ9606 intact-crc:10206AFB2380FC41|rigid:0RSOzMCHb/g+/oq4DFqtfxk4dow false tag:?-?(MINT-6796881) binding-associated region:814-1059(MINT-6796891)|tag:?-?(MINT-6796888) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q66K74 uniprotkb:O14543 intact:EBI-2133734|uniprotkb:Q8N3W5|uniprotkb:Q8NI88|uniprotkb:Q8N3L8|uniprotkb:Q27QB1|uniprotkb:Q96H94|uniprotkb:Q96IT4|uniprotkb:Q96SP8|uniprotkb:Q9BRC6|uniprotkb:Q9H928|uniprotkb:Q9NVK7|uniprotkb:Q6NXF1|ensembl:ENSP00000325313|intact:EBI-2556419|intact:EBI-10978604|uniprotkb:B4DH53|intact:EBI-28978421 intact:EBI-714146|uniprotkb:O14509|ensembl:ENSP00000330341 psi-mi:map1s_human(display_long)|uniprotkb:MAP1S(gene name)|psi-mi:MAP1S(display_short)|uniprotkb:BPY2IP1(gene name synonym)|uniprotkb:C19orf5(gene name synonym)|uniprotkb:MAP8(gene name synonym)|uniprotkb:VCY2IP1(gene name synonym)|uniprotkb:BPY2-interacting protein 1(gene name synonym)|uniprotkb:Microtubule-associated protein 8(gene name synonym)|uniprotkb:Variable charge Y chromosome 2-interacting protein 1(gene name synonym) psi-mi:socs3_human(display_long)|uniprotkb:Cytokine-inducible SH2 protein 3(gene name synonym)|uniprotkb:STAT-induced STAT inhibitor 3(gene name synonym)|uniprotkb:SOCS3(gene name)|psi-mi:SOCS3(display_short)|uniprotkb:CIS3(gene name synonym)|uniprotkb:SSI3(gene name synonym) psi-mi:"MI:0018"(two hybrid) Zou et al. (2008) mint:MINT-6796846|pubmed:19027008|imex:IM-9592|doi:10.1016/j.febslet.2008.10.055|mint:d-08-01699 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8506195|mint:MINT-6796894|imex:IM-9592-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000130479(gene)|ensembl:ENST00000324096(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007409"(axonogenesis)|refseq:NP_001295292.1|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0010848"(regulation of chromatin disassembly)|go:"GO:0015631"(tubulin binding)|go:"GO:0016358"(dendrite development)|go:"GO:0030054"(cell junction)|go:"GO:0030425"(dendrite)|go:"GO:0031114"(regulation of microtubule depolymerization)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051015"(actin filament binding)|interpro:IPR026074|ensembl:ENSP00000325313|ensembl:ENST00000544059|ensembl:ENSP00000439243|refseq:NP_060644.4|interpro:IPR027322|mint:Q66K74|mint:MINT-6796896(identity) go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0060708"(spongiotrophoblast differentiation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR028414|interpro:IPR035863|interpro:IPR036036|interpro:IPR036860|mint:O14543|reactome:R-HSA-1059683|reactome:R-HSA-2586552|reactome:R-HSA-6785807|reactome:R-HSA-877300|reactome:R-HSA-877312|reactome:R-HSA-8849474|reactome:R-HSA-8939242|reactome:R-HSA-8951664|reactome:R-HSA-909733|reactome:R-HSA-912694|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-983168|go:"GO:0050728"(negative regulation of inflammatory response)|ensembl:ENSG00000184557(gene)|ensembl:ENST00000330871(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|refseq:NP_003946.3|mint:MINT-6796902(identity) - - - figure legend:F1A|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2008/11/05 2014/10/16 rogid:f+UnRFHFEFKp2fTRCHt4/HXtnFQ9606 rogid:8HnU9EL52BGdud2WFZwYsv5R22I9606 intact-crc:D1830A02D8ADD914|rigid:0RSOzMCHb/g+/oq4DFqtfxk4dow false binding-associated region:765-980(MINT-6796897)|tag:?-?(MINT-6796899) tag:?-?(MINT-6796903) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q66K74 uniprotkb:O14543 intact:EBI-2133734|uniprotkb:Q8N3W5|uniprotkb:Q8NI88|uniprotkb:Q8N3L8|uniprotkb:Q27QB1|uniprotkb:Q96H94|uniprotkb:Q96IT4|uniprotkb:Q96SP8|uniprotkb:Q9BRC6|uniprotkb:Q9H928|uniprotkb:Q9NVK7|uniprotkb:Q6NXF1|ensembl:ENSP00000325313|intact:EBI-2556419|intact:EBI-10978604|uniprotkb:B4DH53|intact:EBI-28978421 intact:EBI-714146|uniprotkb:O14509|ensembl:ENSP00000330341 psi-mi:map1s_human(display_long)|uniprotkb:MAP1S(gene name)|psi-mi:MAP1S(display_short)|uniprotkb:BPY2IP1(gene name synonym)|uniprotkb:C19orf5(gene name synonym)|uniprotkb:MAP8(gene name synonym)|uniprotkb:VCY2IP1(gene name synonym)|uniprotkb:BPY2-interacting protein 1(gene name synonym)|uniprotkb:Microtubule-associated protein 8(gene name synonym)|uniprotkb:Variable charge Y chromosome 2-interacting protein 1(gene name synonym) psi-mi:socs3_human(display_long)|uniprotkb:Cytokine-inducible SH2 protein 3(gene name synonym)|uniprotkb:STAT-induced STAT inhibitor 3(gene name synonym)|uniprotkb:SOCS3(gene name)|psi-mi:SOCS3(display_short)|uniprotkb:CIS3(gene name synonym)|uniprotkb:SSI3(gene name synonym) psi-mi:"MI:0018"(two hybrid) Zou et al. (2008) mint:MINT-6796846|pubmed:19027008|imex:IM-9592|doi:10.1016/j.febslet.2008.10.055|mint:d-08-01699 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8506255|mint:MINT-6796909|imex:IM-9592-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000130479(gene)|ensembl:ENST00000324096(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007409"(axonogenesis)|refseq:NP_001295292.1|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0010848"(regulation of chromatin disassembly)|go:"GO:0015631"(tubulin binding)|go:"GO:0016358"(dendrite development)|go:"GO:0030054"(cell junction)|go:"GO:0030425"(dendrite)|go:"GO:0031114"(regulation of microtubule depolymerization)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051015"(actin filament binding)|interpro:IPR026074|ensembl:ENSP00000325313|ensembl:ENST00000544059|ensembl:ENSP00000439243|refseq:NP_060644.4|interpro:IPR027322|mint:Q66K74|mint:MINT-6796915(identity) go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0060708"(spongiotrophoblast differentiation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR028414|interpro:IPR035863|interpro:IPR036036|interpro:IPR036860|mint:O14543|reactome:R-HSA-1059683|reactome:R-HSA-2586552|reactome:R-HSA-6785807|reactome:R-HSA-877300|reactome:R-HSA-877312|reactome:R-HSA-8849474|reactome:R-HSA-8939242|reactome:R-HSA-8951664|reactome:R-HSA-909733|reactome:R-HSA-912694|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-983168|go:"GO:0050728"(negative regulation of inflammatory response)|ensembl:ENSG00000184557(gene)|ensembl:ENST00000330871(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|refseq:NP_003946.3|mint:MINT-6796911(identity) - - - figure legend:F2C|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2008/11/05 2014/10/16 rogid:f+UnRFHFEFKp2fTRCHt4/HXtnFQ9606 rogid:8HnU9EL52BGdud2WFZwYsv5R22I9606 intact-crc:02DCD40C30FC42E0|rigid:0RSOzMCHb/g+/oq4DFqtfxk4dow false tag:?-?(MINT-6796916) binding-associated region:164-185(MINT-6797863)|tag:?-?(MINT-6796912) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O14543 uniprotkb:Q66K74 intact:EBI-714146|uniprotkb:O14509|ensembl:ENSP00000330341 intact:EBI-2133734|uniprotkb:Q8N3W5|uniprotkb:Q8NI88|uniprotkb:Q8N3L8|uniprotkb:Q27QB1|uniprotkb:Q96H94|uniprotkb:Q96IT4|uniprotkb:Q96SP8|uniprotkb:Q9BRC6|uniprotkb:Q9H928|uniprotkb:Q9NVK7|uniprotkb:Q6NXF1|ensembl:ENSP00000325313|intact:EBI-2556419|intact:EBI-10978604|uniprotkb:B4DH53|intact:EBI-28978421 psi-mi:socs3_human(display_long)|uniprotkb:Cytokine-inducible SH2 protein 3(gene name synonym)|uniprotkb:STAT-induced STAT inhibitor 3(gene name synonym)|uniprotkb:SOCS3(gene name)|psi-mi:SOCS3(display_short)|uniprotkb:CIS3(gene name synonym)|uniprotkb:SSI3(gene name synonym) psi-mi:map1s_human(display_long)|uniprotkb:MAP1S(gene name)|psi-mi:MAP1S(display_short)|uniprotkb:BPY2IP1(gene name synonym)|uniprotkb:C19orf5(gene name synonym)|uniprotkb:MAP8(gene name synonym)|uniprotkb:VCY2IP1(gene name synonym)|uniprotkb:BPY2-interacting protein 1(gene name synonym)|uniprotkb:Microtubule-associated protein 8(gene name synonym)|uniprotkb:Variable charge Y chromosome 2-interacting protein 1(gene name synonym) psi-mi:"MI:0096"(pull down) Zou et al. (2008) mint:MINT-6796846|pubmed:19027008|imex:IM-9592|doi:10.1016/j.febslet.2008.10.055|mint:d-08-01699 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8506315|mint:MINT-6796957|imex:IM-9592-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0060708"(spongiotrophoblast differentiation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR028414|interpro:IPR035863|interpro:IPR036036|interpro:IPR036860|mint:O14543|reactome:R-HSA-1059683|reactome:R-HSA-2586552|reactome:R-HSA-6785807|reactome:R-HSA-877300|reactome:R-HSA-877312|reactome:R-HSA-8849474|reactome:R-HSA-8939242|reactome:R-HSA-8951664|reactome:R-HSA-909733|reactome:R-HSA-912694|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-983168|go:"GO:0050728"(negative regulation of inflammatory response)|ensembl:ENSG00000184557(gene)|ensembl:ENST00000330871(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|refseq:NP_003946.3|mint:MINT-6796963(identity) ensembl:ENSG00000130479(gene)|ensembl:ENST00000324096(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007409"(axonogenesis)|refseq:NP_001295292.1|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0010848"(regulation of chromatin disassembly)|go:"GO:0015631"(tubulin binding)|go:"GO:0016358"(dendrite development)|go:"GO:0030054"(cell junction)|go:"GO:0030425"(dendrite)|go:"GO:0031114"(regulation of microtubule depolymerization)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051015"(actin filament binding)|interpro:IPR026074|ensembl:ENSP00000325313|ensembl:ENST00000544059|ensembl:ENSP00000439243|refseq:NP_060644.4|interpro:IPR027322|mint:Q66K74|mint:MINT-6796959(identity) - - - figure legend:F1B F2B|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2008/11/05 2014/10/16 rogid:8HnU9EL52BGdud2WFZwYsv5R22I9606 rogid:f+UnRFHFEFKp2fTRCHt4/HXtnFQ9606 intact-crc:7068A4DCDA05F0E8|rigid:0RSOzMCHb/g+/oq4DFqtfxk4dow false glutathione s tranferase tag:?-?(MINT-6796966)|binding-associated region:164-185(MINT-6796964) flag tag:?-?(MINT-6796960) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:O14543 uniprotkb:Q66K74 intact:EBI-714146|uniprotkb:O14509|ensembl:ENSP00000330341 intact:EBI-2133734|uniprotkb:Q8N3W5|uniprotkb:Q8NI88|uniprotkb:Q8N3L8|uniprotkb:Q27QB1|uniprotkb:Q96H94|uniprotkb:Q96IT4|uniprotkb:Q96SP8|uniprotkb:Q9BRC6|uniprotkb:Q9H928|uniprotkb:Q9NVK7|uniprotkb:Q6NXF1|ensembl:ENSP00000325313|intact:EBI-2556419|intact:EBI-10978604|uniprotkb:B4DH53|intact:EBI-28978421 psi-mi:socs3_human(display_long)|uniprotkb:Cytokine-inducible SH2 protein 3(gene name synonym)|uniprotkb:STAT-induced STAT inhibitor 3(gene name synonym)|uniprotkb:SOCS3(gene name)|psi-mi:SOCS3(display_short)|uniprotkb:CIS3(gene name synonym)|uniprotkb:SSI3(gene name synonym) psi-mi:map1s_human(display_long)|uniprotkb:MAP1S(gene name)|psi-mi:MAP1S(display_short)|uniprotkb:BPY2IP1(gene name synonym)|uniprotkb:C19orf5(gene name synonym)|uniprotkb:MAP8(gene name synonym)|uniprotkb:VCY2IP1(gene name synonym)|uniprotkb:BPY2-interacting protein 1(gene name synonym)|uniprotkb:Microtubule-associated protein 8(gene name synonym)|uniprotkb:Variable charge Y chromosome 2-interacting protein 1(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Zou et al. (2008) mint:MINT-6796846|pubmed:19027008|imex:IM-9592|doi:10.1016/j.febslet.2008.10.055|mint:d-08-01699 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-8506377|mint:MINT-6796979|imex:IM-9592-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0060708"(spongiotrophoblast differentiation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR028414|interpro:IPR035863|interpro:IPR036036|interpro:IPR036860|mint:O14543|reactome:R-HSA-1059683|reactome:R-HSA-2586552|reactome:R-HSA-6785807|reactome:R-HSA-877300|reactome:R-HSA-877312|reactome:R-HSA-8849474|reactome:R-HSA-8939242|reactome:R-HSA-8951664|reactome:R-HSA-909733|reactome:R-HSA-912694|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-983168|go:"GO:0050728"(negative regulation of inflammatory response)|ensembl:ENSG00000184557(gene)|ensembl:ENST00000330871(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|refseq:NP_003946.3|mint:MINT-6796981(identity) ensembl:ENSG00000130479(gene)|ensembl:ENST00000324096(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007409"(axonogenesis)|refseq:NP_001295292.1|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0010848"(regulation of chromatin disassembly)|go:"GO:0015631"(tubulin binding)|go:"GO:0016358"(dendrite development)|go:"GO:0030054"(cell junction)|go:"GO:0030425"(dendrite)|go:"GO:0031114"(regulation of microtubule depolymerization)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051015"(actin filament binding)|interpro:IPR026074|ensembl:ENSP00000325313|ensembl:ENST00000544059|ensembl:ENSP00000439243|refseq:NP_060644.4|interpro:IPR027322|mint:Q66K74|mint:MINT-6796987(identity) go:"GO:0005737"(cytoplasm) - - figure legend:F3|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2008/11/05 2014/10/16 rogid:8HnU9EL52BGdud2WFZwYsv5R22I9606 rogid:f+UnRFHFEFKp2fTRCHt4/HXtnFQ9606 intact-crc:E974C1E2140E7398|rigid:0RSOzMCHb/g+/oq4DFqtfxk4dow false binding-associated region:164-185(MINT-6796984)|green fluorescent protein tag:?-?(MINT-6796982) flag tag:?-?(MINT-6796988) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0707"(anti tag immunostaining) uniprotkb:Q66K74 uniprotkb:O35718 intact:EBI-2133734|uniprotkb:Q8N3W5|uniprotkb:Q8NI88|uniprotkb:Q8N3L8|uniprotkb:Q27QB1|uniprotkb:Q96H94|uniprotkb:Q96IT4|uniprotkb:Q96SP8|uniprotkb:Q9BRC6|uniprotkb:Q9H928|uniprotkb:Q9NVK7|uniprotkb:Q6NXF1|ensembl:ENSP00000325313|intact:EBI-2556419|intact:EBI-10978604|uniprotkb:B4DH53|intact:EBI-28978421 intact:EBI-2659360|uniprotkb:Q3U7X5|uniprotkb:P97803|ensembl:ENSMUSP00000059129 psi-mi:map1s_human(display_long)|uniprotkb:MAP1S(gene name)|psi-mi:MAP1S(display_short)|uniprotkb:BPY2IP1(gene name synonym)|uniprotkb:C19orf5(gene name synonym)|uniprotkb:MAP8(gene name synonym)|uniprotkb:VCY2IP1(gene name synonym)|uniprotkb:BPY2-interacting protein 1(gene name synonym)|uniprotkb:Microtubule-associated protein 8(gene name synonym)|uniprotkb:Variable charge Y chromosome 2-interacting protein 1(gene name synonym) psi-mi:socs3_mouse(display_long)|uniprotkb:Cytokine-inducible SH2 protein 3(gene name synonym)|uniprotkb:Protein EF-10(gene name synonym)|uniprotkb:Cis3(gene name synonym)|uniprotkb:Cish3(gene name synonym)|uniprotkb:Socs3(gene name)|psi-mi:Socs3(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Zou et al. (2008) mint:MINT-6796846|pubmed:19027008|imex:IM-9592|doi:10.1016/j.febslet.2008.10.055|mint:d-08-01699 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8506450|mint:MINT-6796998|imex:IM-9592-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000130479(gene)|ensembl:ENST00000324096(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007409"(axonogenesis)|refseq:NP_001295292.1|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0010848"(regulation of chromatin disassembly)|go:"GO:0015631"(tubulin binding)|go:"GO:0016358"(dendrite development)|go:"GO:0030054"(cell junction)|go:"GO:0030425"(dendrite)|go:"GO:0031114"(regulation of microtubule depolymerization)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051015"(actin filament binding)|interpro:IPR026074|ensembl:ENSP00000325313|ensembl:ENST00000544059|ensembl:ENSP00000439243|refseq:NP_060644.4|interpro:IPR027322|mint:Q66K74|mint:MINT-6797006(identity) refseq:XP_011247009.1|refseq:NP_031733.1|ensembl:ENSMUSG00000053113(gene)|ensembl:ENSMUST00000054002(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0060708"(spongiotrophoblast differentiation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR028414|interpro:IPR035863|interpro:IPR036036|interpro:IPR036860|mint:O35718|rcsb pdb:2BBU|rcsb pdb:2HMH|rcsb pdb:2JZ3|rcsb pdb:4GL9|reactome:R-MMU-1059683|reactome:R-MMU-877300|reactome:R-MMU-877312|reactome:R-MMU-8849474|reactome:R-MMU-8951664|reactome:R-MMU-909733|reactome:R-MMU-9705462|reactome:R-MMU-983168|dip:DIP-29137N|mint:MINT-6797000(identity) - - - figure legend:F1D|comment:Interaction occurs upon LPS stimulation|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-raw264_7)|taxid:10090(Mus musculus monocyte macrophage cell line RAW264) - 2008/11/05 2014/10/16 rogid:f+UnRFHFEFKp2fTRCHt4/HXtnFQ9606 rogid:SFk8FM1xo7SkodsiFXZYzTbLrYg10090 intact-crc:3300E57C77D54DAF|rigid:ulOgAYzm/wJDDFM/f0v6TSEvU9Q false flag tag:?-?(MINT-6797007) - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8C052 uniprotkb:O35718 intact:EBI-8318945|uniprotkb:E9QKR8|uniprotkb:Q3TSD6|intact:MINT-4113762|uniprotkb:Q7TMW8|ensembl:ENSMUSP00000019405 intact:EBI-2659360|uniprotkb:Q3U7X5|uniprotkb:P97803|ensembl:ENSMUSP00000059129 psi-mi:map1s_mouse(display_long)|uniprotkb:Bpy2ip1(gene name synonym)|uniprotkb:Map8(gene name synonym)|uniprotkb:Mtap1s(gene name synonym)|uniprotkb:Map1s(gene name)|psi-mi:Map1s(display_short)|uniprotkb:BPY2-interacting protein 1(gene name synonym)|uniprotkb:Microtubule-associated protein 8(gene name synonym) psi-mi:socs3_mouse(display_long)|uniprotkb:Cytokine-inducible SH2 protein 3(gene name synonym)|uniprotkb:Protein EF-10(gene name synonym)|uniprotkb:Cis3(gene name synonym)|uniprotkb:Cish3(gene name synonym)|uniprotkb:Socs3(gene name)|psi-mi:Socs3(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Zou et al. (2008) mint:MINT-6796846|pubmed:19027008|imex:IM-9592|doi:10.1016/j.febslet.2008.10.055|mint:d-08-01699 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8506484|mint:MINT-6797017|imex:IM-9592-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_766601.2|ensembl:ENSMUSG00000019261(gene)|ensembl:ENSMUST00000019405(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007409"(axonogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0010848"(regulation of chromatin disassembly)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0015631"(tubulin binding)|go:"GO:0016358"(dendrite development)|go:"GO:0030054"(cell junction)|go:"GO:0030425"(dendrite)|go:"GO:0031114"(regulation of microtubule depolymerization)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051015"(actin filament binding)|interpro:IPR026074|interpro:IPR027322|interpro:IPR036866|mint:Q8C052|mint:MINT-6797019(identity) refseq:XP_011247009.1|refseq:NP_031733.1|ensembl:ENSMUSG00000053113(gene)|ensembl:ENSMUST00000054002(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0060708"(spongiotrophoblast differentiation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR028414|interpro:IPR035863|interpro:IPR036036|interpro:IPR036860|mint:O35718|rcsb pdb:2BBU|rcsb pdb:2HMH|rcsb pdb:2JZ3|rcsb pdb:4GL9|reactome:R-MMU-1059683|reactome:R-MMU-877300|reactome:R-MMU-877312|reactome:R-MMU-8849474|reactome:R-MMU-8951664|reactome:R-MMU-909733|reactome:R-MMU-9705462|reactome:R-MMU-983168|dip:DIP-29137N|mint:MINT-6797023(identity) - comment:mint|function:"Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule-organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis (By similarity). Involved in the formation of microtubule bundles" - figure legend:F1C|comment:Interaction occurs upon LPS stimulation|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-raw264_7)|taxid:10090(Mus musculus monocyte macrophage cell line RAW264) - 2008/11/05 2014/10/16 rogid:d3iaGRj7YLEJZpjVMmLIK2y8Zoc10090 rogid:SFk8FM1xo7SkodsiFXZYzTbLrYg10090 intact-crc:289758C98E1EC392|rigid:ZZnBTQlLRk4MNo0Zysh9ko7OwAw false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)