#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P35052 uniprotkb:P13385 intact:EBI-8307554|ensembl:ENSP00000264039|intact:UNK-5376584|uniprotkb:Q53QM4|intact:UNK-5431308|uniprotkb:B3KTD1 intact:EBI-717375|uniprotkb:Q8TCC1|ensembl:ENSP00000296145 psi-mi:gpc1_human(display_long)|uniprotkb:GPC1(gene name)|psi-mi:GPC1(display_short) psi-mi:tdgf1_human(display_long)|uniprotkb:Epidermal growth factor-like cripto protein CR1(gene name synonym)|uniprotkb:Cripto-1 growth factor(gene name synonym)|uniprotkb:TDGF1(gene name)|psi-mi:TDGF1(display_short)|uniprotkb:CRIPTO(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Bianco et al. (2008) pubmed:19013461|imex:IM-9593|mint:MINT-6797290|doi:10.1016/j.febslet.2008.10.052|mint:d-08-01819 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8498140|mint:MINT-6797299|imex:IM-9593-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000063660(gene)|ensembl:ENST00000264039(transcript)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0014037"(Schwann cell differentiation)|go:"GO:0016477"(cell migration)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0030200"(heparan sulfate proteoglycan catabolic process)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0032288"(myelin assembly)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043236"(laminin binding)|go:"GO:0045121"(membrane raft)|reactome:R-HSA-2024096|reactome:R-HSA-202733|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3656237|reactome:R-HSA-3656253|reactome:R-HSA-376176|reactome:R-HSA-4420332|reactome:R-HSA-975634|go:"GO:0045202"(synapse)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:1905475"(regulation of protein localization to membrane)|go:"GO:2001016"(positive regulation of skeletal muscle cell differentiation)|interpro:IPR001863(Glypican)|interpro:IPR015502(Glypican1)|interpro:IPR019803|mint:P35052|rcsb pdb:4ACR|rcsb pdb:4AD7|rcsb pdb:4BWE|rcsb pdb:4YWT|reactome:R-HSA-1971475|reactome:R-HSA-2022928|refseq:NP_002072.2|mint:MINT-6797302(identity) refseq:NP_001167607.1|refseq:NP_003203.1|ensembl:ENSG00000241186(gene)|ensembl:ENST00000296145(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001568"(blood vessel development)|go:"GO:0001763"(morphogenesis of a branching structure)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008595"(anterior/posterior axis specification, embryo)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030879"(mammary gland development)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0038092"(nodal signaling pathway)|go:"GO:0038100"(nodal binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0070697"(activin receptor binding)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR017047(Teratocarcinoma-derived growth factor Cripto)|interpro:IPR019011|mint:P13385|reactome:R-HSA-1181150|reactome:R-HSA-1433617|reactome:R-HSA-2892247|mint:MINT-6797301(identity) - function:Cell surface proteoglycan that bears heparan sulfate|comment:mint - figure legend:F4A|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2008/11/06 2014/10/16 rogid:ycuKz8cHA1TlfV2XkBz+onEEwyw9606 rogid:Gk7hyokP90QQkFpvaW07k4/rRII9606 intact-crc:10D2598F2DF0F195|rigid:0CwhlFy5c9VOTTI29q6sEohzwL4 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)