#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
chebi:"CHEBI:16761"	chebi:"CHEBI:18420"	intact:EBI-1188073	intact:EBI-967760	psi-mi:adp(display_short)|psi-mi:"CHEBI:16761"(display_long)	psi-mi:"magnesium(2+)"(display_short)|psi-mi:"CHEBI:18420"(display_long)	psi-mi:"MI:0114"(x-ray crystallography)	Mott et al. (2008)	imex:IM-12147|pubmed:19013274	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2120445|wwpdb:3ECC|imex:IM-12147-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0328"(small molecule)	-	-	-	-	-	comment:Crystals were soaked in BeF3 following ADP binding - BeF3 is a widely used substitute for the gamma-phosphate of ATP|3d-resolution:2.7A|3d-r-factors:working = 26.3%, free = 29.4%|caution:The sequence given in the PDB file does not match the coordinates given in the paper. The entry has been mapped to the residues stated in the PDB file.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/12/01	2014/10/16	-	-	intact-crc:C2BA6394D4C223F4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:16761"	uniprotkb:O67056	intact:EBI-1188073	intact:EBI-2120435|ensemblbacteria:AAC07013	psi-mi:adp(display_short)|psi-mi:"CHEBI:16761"(display_long)	psi-mi:o67056_aquae(display_long)|uniprotkb:dnaC(gene name)|psi-mi:dnaC(display_short)|uniprotkb:aq_910(locus name)	psi-mi:"MI:0114"(x-ray crystallography)	Mott et al. (2008)	imex:IM-12147|pubmed:19013274	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:224324(aquae)|taxid:224324("Aquifex aeolicus (strain VF5)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2120445|wwpdb:3ECC|imex:IM-12147-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR002611(IstB-like ATP-binding protein)|refseq:NP_213618.1|rcsb pdb:3EC2|rcsb pdb:3ECC|refseq:WP_010880556.1|interpro:IPR027417|ensemblbacteria:AAC07013(transcript)|ensemblbacteria:aq_910(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0042802"(identical protein binding)	-	-	-	comment:Crystals were soaked in BeF3 following ADP binding - BeF3 is a widely used substitute for the gamma-phosphate of ATP|3d-resolution:2.7A|3d-r-factors:working = 26.3%, free = 29.4%|caution:The sequence given in the PDB file does not match the coordinates given in the paper. The entry has been mapped to the residues stated in the PDB file.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/12/01	2014/10/16	-	rogid:xjRFEQQKwAO7u6yuL6Ncr6AiSaI224324	intact-crc:C2BA6394D4C223F4	false	-	sufficient binding region:43-226	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:16761"	chebi:"CHEBI:30498"	intact:EBI-1188073	intact:EBI-2120453	psi-mi:adp(display_short)|psi-mi:"CHEBI:16761"(display_long)	psi-mi:"trifluoroberyllate(1-)"(display_short)|psi-mi:"CHEBI:30498"(display_long)	psi-mi:"MI:0114"(x-ray crystallography)	Mott et al. (2008)	imex:IM-12147|pubmed:19013274	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2120445|wwpdb:3ECC|imex:IM-12147-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0328"(small molecule)	-	-	-	-	comment:a widely used substitute for the γ-phosphate of ATP	comment:Crystals were soaked in BeF3 following ADP binding - BeF3 is a widely used substitute for the gamma-phosphate of ATP|3d-resolution:2.7A|3d-r-factors:working = 26.3%, free = 29.4%|caution:The sequence given in the PDB file does not match the coordinates given in the paper. The entry has been mapped to the residues stated in the PDB file.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/12/01	2014/10/16	-	-	intact-crc:C2BA6394D4C223F4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:16761"	chebi:"CHEBI:18420"	intact:EBI-1188073	intact:EBI-967760	psi-mi:adp(display_short)|psi-mi:"CHEBI:16761"(display_long)	psi-mi:"magnesium(2+)"(display_short)|psi-mi:"CHEBI:18420"(display_long)	psi-mi:"MI:0114"(x-ray crystallography)	Mott et al. (2008)	imex:IM-12147|pubmed:19013274	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2127274|wwpdb:3EC2|imex:IM-12147-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0328"(small molecule)	-	-	-	-	-	3d-resolution:2.7A|3d-r-factors:working = 23.3%, free = 27.8%|comment:Residues 188-190 were not visible in the crystal.|caution:The sequence given in the PDB file does not match the coordinates given in the paper. the entry has been mapped to the residues stated in the PDB file.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/12/01	2014/10/16	-	-	intact-crc:911D6A8169E63D27	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:16761"	uniprotkb:O67056	intact:EBI-1188073	intact:EBI-2120435|ensemblbacteria:AAC07013	psi-mi:adp(display_short)|psi-mi:"CHEBI:16761"(display_long)	psi-mi:o67056_aquae(display_long)|uniprotkb:dnaC(gene name)|psi-mi:dnaC(display_short)|uniprotkb:aq_910(locus name)	psi-mi:"MI:0114"(x-ray crystallography)	Mott et al. (2008)	imex:IM-12147|pubmed:19013274	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:224324(aquae)|taxid:224324("Aquifex aeolicus (strain VF5)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2127274|wwpdb:3EC2|imex:IM-12147-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR002611(IstB-like ATP-binding protein)|refseq:NP_213618.1|rcsb pdb:3EC2|rcsb pdb:3ECC|refseq:WP_010880556.1|interpro:IPR027417|ensemblbacteria:AAC07013(transcript)|ensemblbacteria:aq_910(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0042802"(identical protein binding)	-	-	-	3d-resolution:2.7A|3d-r-factors:working = 23.3%, free = 27.8%|comment:Residues 188-190 were not visible in the crystal.|caution:The sequence given in the PDB file does not match the coordinates given in the paper. the entry has been mapped to the residues stated in the PDB file.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/12/01	2014/10/16	-	rogid:xjRFEQQKwAO7u6yuL6Ncr6AiSaI224324	intact-crc:911D6A8169E63D27	false	-	sufficient binding region:43-226	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O67056	uniprotkb:O67056	intact:EBI-2120435|ensemblbacteria:AAC07013	intact:EBI-2120435|ensemblbacteria:AAC07013	psi-mi:o67056_aquae(display_long)|uniprotkb:dnaC(gene name)|psi-mi:dnaC(display_short)|uniprotkb:aq_910(locus name)	psi-mi:o67056_aquae(display_long)|uniprotkb:dnaC(gene name)|psi-mi:dnaC(display_short)|uniprotkb:aq_910(locus name)	psi-mi:"MI:0030"(cross-linking study)	Mott et al. (2008)	imex:IM-12147|pubmed:19013274	taxid:224324(aquae)|taxid:224324("Aquifex aeolicus (strain VF5)")	taxid:224324(aquae)|taxid:224324("Aquifex aeolicus (strain VF5)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2120475|imex:IM-12147-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR002611(IstB-like ATP-binding protein)|refseq:NP_213618.1|rcsb pdb:3EC2|rcsb pdb:3ECC|refseq:WP_010880556.1|interpro:IPR027417|ensemblbacteria:AAC07013(transcript)|ensemblbacteria:aq_910(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0042802"(identical protein binding)	interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR002611(IstB-like ATP-binding protein)|refseq:NP_213618.1|rcsb pdb:3EC2|rcsb pdb:3ECC|refseq:WP_010880556.1|interpro:IPR027417|ensemblbacteria:AAC07013(transcript)|ensemblbacteria:aq_910(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0042802"(identical protein binding)	go:"GO:0051260"(protein homooligomerization)	-	-	figure legend:Figs. 3B Fig. 3C|comment:"DnaC forms a ladder of oligomeric species that run at the expected sizes for dimers, trimers, and higher-order multimers. DnaC can crystallize as an oligomer in the presence of ADP, but ATP (or ADP.BeF3) further facilitates the formation of this state, probably due to the presence of extra contacts within the active site."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/12/01	2014/10/16	rogid:xjRFEQQKwAO7u6yuL6Ncr6AiSaI224324	rogid:xjRFEQQKwAO7u6yuL6Ncr6AiSaI224324	intact-crc:4777CAC3CBBD3E99|rigid:sHW6x5Kv4ViLR7bYXBiVzHA6vpA	false	mutation decreasing interaction:165-165|mutation decreasing interaction:121-121	mutation decreasing interaction:165-165|mutation decreasing interaction:121-121	-	0	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:O67056	uniprotkb:O67056	intact:EBI-2120435|ensemblbacteria:AAC07013	intact:EBI-2120435|ensemblbacteria:AAC07013	psi-mi:o67056_aquae(display_long)|uniprotkb:dnaC(gene name)|psi-mi:dnaC(display_short)|uniprotkb:aq_910(locus name)	psi-mi:o67056_aquae(display_long)|uniprotkb:dnaC(gene name)|psi-mi:dnaC(display_short)|uniprotkb:aq_910(locus name)	psi-mi:"MI:0096"(pull down)	Mott et al. (2008)	imex:IM-12147|pubmed:19013274	taxid:224324(aquae)|taxid:224324("Aquifex aeolicus (strain VF5)")	taxid:224324(aquae)|taxid:224324("Aquifex aeolicus (strain VF5)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2120573|imex:IM-12147-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR002611(IstB-like ATP-binding protein)|refseq:NP_213618.1|rcsb pdb:3EC2|rcsb pdb:3ECC|refseq:WP_010880556.1|interpro:IPR027417|ensemblbacteria:AAC07013(transcript)|ensemblbacteria:aq_910(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0042802"(identical protein binding)	interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR002611(IstB-like ATP-binding protein)|refseq:NP_213618.1|rcsb pdb:3EC2|rcsb pdb:3ECC|refseq:WP_010880556.1|interpro:IPR027417|ensemblbacteria:AAC07013(transcript)|ensemblbacteria:aq_910(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0042802"(identical protein binding)	go:"GO:0051260"(protein homooligomerization)	-	-	figure legend:Figs. 5A|comment:Interaction requires ATP or a mimetic.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/12/01	2014/10/16	rogid:xjRFEQQKwAO7u6yuL6Ncr6AiSaI224324	rogid:xjRFEQQKwAO7u6yuL6Ncr6AiSaI224324	intact-crc:87AE258172BAE89F|rigid:gu7m4g7hAo+Q4Xq2x4seYr8PhX0	false	mutation decreasing interaction:165-165,121-121|sufficient binding region:?-?	maltose binding protein tag:?-?|sufficient binding region:?-?	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
chebi:"CHEBI:16761"	uniprotkb:O67056	intact:EBI-1188073	intact:EBI-2120435|ensemblbacteria:AAC07013	psi-mi:adp(display_short)|psi-mi:"CHEBI:16761"(display_long)	psi-mi:o67056_aquae(display_long)|uniprotkb:dnaC(gene name)|psi-mi:dnaC(display_short)|uniprotkb:aq_910(locus name)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Mott et al. (2008)	imex:IM-12147|pubmed:19013274	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:224324(aquae)|taxid:224324("Aquifex aeolicus (strain VF5)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2120606|imex:IM-12147-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR002611(IstB-like ATP-binding protein)|refseq:NP_213618.1|rcsb pdb:3EC2|rcsb pdb:3ECC|refseq:WP_010880556.1|interpro:IPR027417|ensemblbacteria:AAC07013(transcript)|ensemblbacteria:aq_910(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0042802"(identical protein binding)	-	-	-	figure legend:Supp Fig. 1A|comment:Nucleotides are labelled with BODIPY-fluorescein|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/12/01	2014/10/16	-	rogid:xjRFEQQKwAO7u6yuL6Ncr6AiSaI224324	intact-crc:1DB777AA6B601E7F	false	-	sufficient binding region:43-235	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:15422"	uniprotkb:O67056	intact:EBI-1108845|chebi:"CHEBI:40938"|chebi:"CHEBI:10841"|chebi:"CHEBI:10789"|chebi:"CHEBI:2359"|chebi:"CHEBI:13236"|chebi:"CHEBI:22249"	intact:EBI-2120435|ensemblbacteria:AAC07013	psi-mi:atp(display_short)|psi-mi:"CHEBI:15422"(display_long)|intact:Adenosine 5'-triphosphate(synonym)|intact:Adenosine triphosphate(synonym)|intact:ADENOSINE-5'-TRIPHOSPHATE(synonym)|intact:Adephos(synonym)|intact:Adetol(synonym)|intact:Adynol(synonym)|intact:Atipi(synonym)|intact:ATP(synonym)|intact:Atriphos(synonym)|intact:Cardenosine(synonym)|intact:Fosfobion(synonym)|intact:Glucobasin(synonym)|intact:H4atp(synonym)|intact:Myotriphos(synonym)|intact:Triadenyl(synonym)|intact:Triphosphaden(synonym)|intact:"adenosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:o67056_aquae(display_long)|uniprotkb:dnaC(gene name)|psi-mi:dnaC(display_short)|uniprotkb:aq_910(locus name)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Mott et al. (2008)	imex:IM-12147|pubmed:19013274	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:224324(aquae)|taxid:224324("Aquifex aeolicus (strain VF5)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2120618|imex:IM-12147-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR002611(IstB-like ATP-binding protein)|refseq:NP_213618.1|rcsb pdb:3EC2|rcsb pdb:3ECC|refseq:WP_010880556.1|interpro:IPR027417|ensemblbacteria:AAC07013(transcript)|ensemblbacteria:aq_910(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0042802"(identical protein binding)	-	-	-	figure legend:Supp Fig. 1|comment:Nucleotides are labelled with BODIPY-fluorescein|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/12/01	2014/10/16	-	rogid:xjRFEQQKwAO7u6yuL6Ncr6AiSaI224324	intact-crc:3E731BA1C44AC793	false	-	sufficient binding region:43-235|mutation disrupting interaction:92-92	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)