#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q8IZD9 uniprotkb:Q14511 intact:EBI-1752361|uniprotkb:O15017|ensembl:ENSP00000266037 intact:EBI-2108053|uniprotkb:Q5T9R4|uniprotkb:A8K9G7|uniprotkb:G5E9Y9|uniprotkb:A8MSJ9|uniprotkb:Q5XKI0|intact:EBI-28980032|ensembl:ENSP00000368759 psi-mi:dock3_human(display_long)|uniprotkb:DOCK3(gene name)|psi-mi:DOCK3(display_short)|uniprotkb:KIAA0299(gene name synonym)|uniprotkb:MOCA(gene name synonym)|uniprotkb:Modifier of cell adhesion(gene name synonym)|uniprotkb:Presenilin-binding protein(gene name synonym) psi-mi:casl_human(display_long)|uniprotkb:NEDD9(gene name)|psi-mi:NEDD9(display_short)|uniprotkb:CASL(gene name synonym)|uniprotkb:CASS2(gene name synonym)|uniprotkb:CRK-associated substrate-related protein(gene name synonym)|uniprotkb:p105(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 9(gene name synonym)|uniprotkb:Cas scaffolding protein family member 2(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-12(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Sanz-Moreno et al. (2008) imex:IM-12141|pubmed:18984162 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2108077|imex:IM-12141-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000266037|refseq:NP_004938.1|ensembl:ENSG00000088538(gene)|ensembl:ENST00000266037(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:1903997"(positive regulation of non-membrane spanning protein tyrosine kinase activity)|interpro:IPR001452(Src homology-3)|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026791|interpro:IPR026800|interpro:IPR027007|interpro:IPR027357|interpro:IPR032376|interpro:IPR035767|interpro:IPR035892|interpro:IPR036028|interpro:IPR037811|interpro:IPR042455|interpro:IPR043161|interpro:IPR043162|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9032759|reactome:R-HSA-983231 refseq:NP_006394.1|refseq:NP_892011.2|refseq:NP_001135865.1|ensembl:ENST00000379433|ensembl:ENSP00000368745|ensembl:ENSP00000368759|ensembl:ENST00000504387|ensembl:ENSP00000422871|refseq:NP_001257962.1|interpro:IPR035746|interpro:IPR036028|interpro:IPR037362|interpro:IPR038319|mint:Q14511|rcsb pdb:2L81|rcsb pdb:5X3S|ensembl:ENSG00000111859(gene)|ensembl:ENST00000379446(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0040008"(regulation of growth)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051301"(cell division)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090527"(actin filament reorganization)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001452(Src homology-3)|interpro:IPR014928(Serine rich protein interaction)|interpro:IPR021901 psi-mi:"MI:0469"(intact) - - figure legend:Fig 3D|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-a357m2)|taxid:9606(Human metastatic melanoma cell line) - 2008/11/13 2014/10/16 rogid:iOab1J+w2HOMYtMCju+iysQ6oT09606 rogid:3PsYJXDgAihLYOOwKMBtDhQZQkU9606 intact-crc:1613F51DF041A578|rigid:0H7szZ1Ds6jidf03fAWJvGxMvA4 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q14511 uniprotkb:Q8IZD9 intact:EBI-2108053|uniprotkb:Q5T9R4|uniprotkb:A8K9G7|uniprotkb:G5E9Y9|uniprotkb:A8MSJ9|uniprotkb:Q5XKI0|intact:EBI-28980032|ensembl:ENSP00000368759 intact:EBI-1752361|uniprotkb:O15017|ensembl:ENSP00000266037 psi-mi:casl_human(display_long)|uniprotkb:NEDD9(gene name)|psi-mi:NEDD9(display_short)|uniprotkb:CASL(gene name synonym)|uniprotkb:CASS2(gene name synonym)|uniprotkb:CRK-associated substrate-related protein(gene name synonym)|uniprotkb:p105(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 9(gene name synonym)|uniprotkb:Cas scaffolding protein family member 2(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-12(gene name synonym) psi-mi:dock3_human(display_long)|uniprotkb:DOCK3(gene name)|psi-mi:DOCK3(display_short)|uniprotkb:KIAA0299(gene name synonym)|uniprotkb:MOCA(gene name synonym)|uniprotkb:Modifier of cell adhesion(gene name synonym)|uniprotkb:Presenilin-binding protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sanz-Moreno et al. (2008) imex:IM-12141|pubmed:18984162 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2108090|imex:IM-12141-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006394.1|refseq:NP_892011.2|refseq:NP_001135865.1|ensembl:ENST00000379433|ensembl:ENSP00000368745|ensembl:ENSP00000368759|ensembl:ENST00000504387|ensembl:ENSP00000422871|refseq:NP_001257962.1|interpro:IPR035746|interpro:IPR036028|interpro:IPR037362|interpro:IPR038319|mint:Q14511|rcsb pdb:2L81|rcsb pdb:5X3S|ensembl:ENSG00000111859(gene)|ensembl:ENST00000379446(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0040008"(regulation of growth)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051301"(cell division)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090527"(actin filament reorganization)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001452(Src homology-3)|interpro:IPR014928(Serine rich protein interaction)|interpro:IPR021901 ensembl:ENSP00000266037|refseq:NP_004938.1|ensembl:ENSG00000088538(gene)|ensembl:ENST00000266037(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:1903997"(positive regulation of non-membrane spanning protein tyrosine kinase activity)|interpro:IPR001452(Src homology-3)|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026791|interpro:IPR026800|interpro:IPR027007|interpro:IPR027357|interpro:IPR032376|interpro:IPR035767|interpro:IPR035892|interpro:IPR036028|interpro:IPR037811|interpro:IPR042455|interpro:IPR043161|interpro:IPR043162|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9032759|reactome:R-HSA-983231 psi-mi:"MI:0469"(intact) - - figure legend:Fig 3D|delivery method:O15017 transfection|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-a357m2)|taxid:9606(Human metastatic melanoma cell line) - 2008/11/13 2014/10/16 rogid:3PsYJXDgAihLYOOwKMBtDhQZQkU9606 rogid:iOab1J+w2HOMYtMCju+iysQ6oT09606 intact-crc:3975BA922C66641A|rigid:0H7szZ1Ds6jidf03fAWJvGxMvA4 false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q14511 uniprotkb:Q8CIQ7 intact:EBI-2108053|uniprotkb:Q5T9R4|uniprotkb:A8K9G7|uniprotkb:G5E9Y9|uniprotkb:A8MSJ9|uniprotkb:Q5XKI0|intact:EBI-28980032|ensembl:ENSP00000368759 intact:EBI-2112210 psi-mi:casl_human(display_long)|uniprotkb:NEDD9(gene name)|psi-mi:NEDD9(display_short)|uniprotkb:CASL(gene name synonym)|uniprotkb:CASS2(gene name synonym)|uniprotkb:CRK-associated substrate-related protein(gene name synonym)|uniprotkb:p105(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 9(gene name synonym)|uniprotkb:Cas scaffolding protein family member 2(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-12(gene name synonym) psi-mi:dock3_mouse(display_long)|uniprotkb:Dock3(gene name)|psi-mi:Dock3(display_short)|uniprotkb:Moca(gene name synonym)|uniprotkb:Modifier of cell adhesion(gene name synonym)|uniprotkb:Presenilin-binding protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sanz-Moreno et al. (2008) imex:IM-12141|pubmed:18984162 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2112226|imex:IM-12141-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006394.1|refseq:NP_892011.2|refseq:NP_001135865.1|ensembl:ENST00000379433|ensembl:ENSP00000368745|ensembl:ENSP00000368759|ensembl:ENST00000504387|ensembl:ENSP00000422871|refseq:NP_001257962.1|interpro:IPR035746|interpro:IPR036028|interpro:IPR037362|interpro:IPR038319|mint:Q14511|rcsb pdb:2L81|rcsb pdb:5X3S|ensembl:ENSG00000111859(gene)|ensembl:ENST00000379446(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0040008"(regulation of growth)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051301"(cell division)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090527"(actin filament reorganization)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001452(Src homology-3)|interpro:IPR014928(Serine rich protein interaction)|interpro:IPR021901 interpro:IPR027357|interpro:IPR016024(Armadillo-type fold)|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR001452(Src homology-3)|interpro:IPR043161|interpro:IPR043162|interpro:IPR032376|interpro:IPR027007|interpro:IPR026800|interpro:IPR026791|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|interpro:IPR035892|interpro:IPR037811|interpro:IPR035767|interpro:IPR036028|reactome:R-MMU-9032759|reactome:R-MMU-983231|interpro:IPR042455|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0017124"(SH3 domain binding) psi-mi:"MI:0469"(intact) - - figure legend:Fig 3D|delivery method:Q8CIQ7 transfection|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-a357m2)|taxid:9606(Human metastatic melanoma cell line) - 2008/11/13 2014/10/16 rogid:3PsYJXDgAihLYOOwKMBtDhQZQkU9606 rogid:Y4Ja4mtQBITd7KP0b5Q+y1L/cME10090 intact-crc:B40D0B7AAE2AA807|rigid:r9J8pjdXz/2jjvSDcOgQYRw7ViA false - ha tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8CIQ7 uniprotkb:Q14511 intact:EBI-2112210 intact:EBI-2108053|uniprotkb:Q5T9R4|uniprotkb:A8K9G7|uniprotkb:G5E9Y9|uniprotkb:A8MSJ9|uniprotkb:Q5XKI0|intact:EBI-28980032|ensembl:ENSP00000368759 psi-mi:dock3_mouse(display_long)|uniprotkb:Dock3(gene name)|psi-mi:Dock3(display_short)|uniprotkb:Moca(gene name synonym)|uniprotkb:Modifier of cell adhesion(gene name synonym)|uniprotkb:Presenilin-binding protein(gene name synonym) psi-mi:casl_human(display_long)|uniprotkb:NEDD9(gene name)|psi-mi:NEDD9(display_short)|uniprotkb:CASL(gene name synonym)|uniprotkb:CASS2(gene name synonym)|uniprotkb:CRK-associated substrate-related protein(gene name synonym)|uniprotkb:p105(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 9(gene name synonym)|uniprotkb:Cas scaffolding protein family member 2(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-12(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Sanz-Moreno et al. (2008) imex:IM-12141|pubmed:18984162 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2112245|imex:IM-12141-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR027357|interpro:IPR016024(Armadillo-type fold)|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR001452(Src homology-3)|interpro:IPR043161|interpro:IPR043162|interpro:IPR032376|interpro:IPR027007|interpro:IPR026800|interpro:IPR026791|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|interpro:IPR035892|interpro:IPR037811|interpro:IPR035767|interpro:IPR036028|reactome:R-MMU-9032759|reactome:R-MMU-983231|interpro:IPR042455|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0017124"(SH3 domain binding) refseq:NP_006394.1|refseq:NP_892011.2|refseq:NP_001135865.1|ensembl:ENST00000379433|ensembl:ENSP00000368745|ensembl:ENSP00000368759|ensembl:ENST00000504387|ensembl:ENSP00000422871|refseq:NP_001257962.1|interpro:IPR035746|interpro:IPR036028|interpro:IPR037362|interpro:IPR038319|mint:Q14511|rcsb pdb:2L81|rcsb pdb:5X3S|ensembl:ENSG00000111859(gene)|ensembl:ENST00000379446(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0040008"(regulation of growth)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051301"(cell division)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090527"(actin filament reorganization)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001452(Src homology-3)|interpro:IPR014928(Serine rich protein interaction)|interpro:IPR021901 psi-mi:"MI:0469"(intact) - - figure legend:Fig 3D|delivery method:Q8CIQ7 transfection|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-a357m2)|taxid:9606(Human metastatic melanoma cell line) - 2008/11/13 2014/10/16 rogid:Y4Ja4mtQBITd7KP0b5Q+y1L/cME10090 rogid:3PsYJXDgAihLYOOwKMBtDhQZQkU9606 intact-crc:E4135B20527A6869|rigid:r9J8pjdXz/2jjvSDcOgQYRw7ViA false ha tag:?-? - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)