#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:A1Z9X0	uniprotkb:O97111	intact:EBI-160861|ensemblmetazoa:FBpp0292487|ensemblmetazoa:FBpp0292491|intact:EBI-2296820|intact:EBI-867915|intact:EBI-2027110|intact:EBI-2656028|uniprotkb:Q0E971|uniprotkb:Q0E972|uniprotkb:Q0E973|uniprotkb:Q0E974|uniprotkb:Q8MT38|uniprotkb:Q9GSZ3	intact:EBI-186645|ensemblmetazoa:FBpp0074229|ensemblmetazoa:FBpp0074230	psi-mi:apkc_drome(display_long)|uniprotkb:aPKC(gene name)|psi-mi:aPKC(display_short)|uniprotkb:CG30475(orf name)	psi-mi:o97111_drome(display_long)|uniprotkb:par-6(gene name)|psi-mi:par-6(display_short)|uniprotkb:DPar-6(gene name synonym)|uniprotkb:DPar6(gene name synonym)|uniprotkb:Dm-Par-6(gene name synonym)|uniprotkb:Dm-Par6(gene name synonym)|uniprotkb:DmPAR-6(gene name synonym)|uniprotkb:DmPar-6(gene name synonym)|uniprotkb:DmPar6(gene name synonym)|uniprotkb:Dmel\CG5884(gene name synonym)|uniprotkb:Dmpar6(gene name synonym)|uniprotkb:PAR-6(gene name synonym)|uniprotkb:PAR6(gene name synonym)|uniprotkb:Par(gene name synonym)|uniprotkb:Par-6(gene name synonym)|uniprotkb:Par6(gene name synonym)|uniprotkb:dPAR-6(gene name synonym)|uniprotkb:dPar-6(gene name synonym)|uniprotkb:dmPar-6(gene name synonym)|uniprotkb:par(gene name synonym)|uniprotkb:par6(gene name synonym)|uniprotkb:Dmel_CG5884(orf name)|uniprotkb:CG5884(orf name)	psi-mi:"MI:0096"(pull down)	Wirtz-Peitz et al. (2008)	imex:IM-12136|pubmed:18854163	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2027106|imex:IM-12136-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001036541.1|refseq:NP_524892.2|flybase:FBgn0261854|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0045176"(apical protein localization)|go:"GO:0045179"(apical cortex)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0045196"(establishment or maintenance of neuroblast polarity)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0046667"(compound eye retinal cell programmed cell death)|go:"GO:0046872"(metal ion binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051601"(exocyst localization)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090163"(establishment of epithelial cell planar polarity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140591"(nuclear envelope budding)|go:"GO:1904580"(regulation of intracellular mRNA localization)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012233(Protein kinase C, zeta/iota)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:0035331"(negative regulation of hippo signaling)|ensemblmetazoa:FBgn0261854(gene)|ensemblmetazoa:FBtr0303430(transcript)|ensemblmetazoa:FBtr0303434(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007294"(germarium-derived oocyte fate determination)|go:"GO:0007314"(oocyte anterior/posterior axis specification)|go:"GO:0007416"(synapse assembly)|go:"GO:0007423"(sensory organ development)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0007613"(memory)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016332"(establishment or maintenance of polarity of embryonic epithelium)|go:"GO:0016334"(establishment or maintenance of polarity of follicular epithelium)|go:"GO:0017022"(myosin binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030860"(regulation of polarized epithelial cell differentiation)|go:"GO:0034332"(adherens junction organization)|go:"GO:0035003"(subapical complex)|go:"GO:0035011"(melanotic encapsulation of foreign target)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034659|interpro:IPR034877|reactome:R-DME-2173791|reactome:R-DME-5218921|reactome:R-DME-9634635|refseq:NP_001036542.1|refseq:NP_001036543.1|refseq:NP_001036544.1|refseq:NP_001036545.1	refseq:NP_573238.1|flybase:FBgn0026192|refseq:NP_728094.1|dip:DIP-17759N|ensemblmetazoa:FBgn0026192(gene)|ensemblmetazoa:FBtr0074455(transcript)|ensemblmetazoa:FBtr0074456(transcript)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007416"(synapse assembly)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016332"(establishment or maintenance of polarity of embryonic epithelium)|go:"GO:0035003"(subapical complex)|go:"GO:0043195"(terminal bouton)|go:"GO:0045176"(apical protein localization)|go:"GO:0045179"(apical cortex)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0045196"(establishment or maintenance of neuroblast polarity)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045200"(establishment of neuroblast polarity)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0060341"(regulation of cellular localization)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0097482"(muscle cell postsynaptic specialization)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR034868|interpro:IPR034873|interpro:IPR036034|rcsb pdb:1RY4|rcsb pdb:1RZX|rcsb pdb:1X8S|rcsb pdb:2LC6|rcsb pdb:2LC7|rcsb pdb:5I7Z|reactome:R-DME-2173791|reactome:R-DME-4608870|reactome:R-DME-9013149	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/11/04	2014/10/16	rogid:w7Lc8l4/50NKAWamwS+Lzk6lbgA7227	rogid:L8COGHmbjA0Br5eyBQPvEeCEQTw7227	intact-crc:A06FF20571D7E145|rigid:HI8mnQRr8Bns3UiQgsj7IO6kZYM	false	-	glutathione s tranferase tag:?-?|mutation decreasing interaction:34-34|mutation decreasing interaction:34-34|mutation decreasing interaction:23-23	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P16554	uniprotkb:A1Z9X0	intact:EBI-429581|uniprotkb:Q8IPE9|uniprotkb:Q961A6|uniprotkb:Q9VLB8|uniprotkb:B8A413|uniprotkb:B8A419|ensemblmetazoa:FBpp0079420|ensemblmetazoa:FBpp0308609	intact:EBI-160861|ensemblmetazoa:FBpp0292487|ensemblmetazoa:FBpp0292491|intact:EBI-2296820|intact:EBI-867915|intact:EBI-2027110|intact:EBI-2656028|uniprotkb:Q0E971|uniprotkb:Q0E972|uniprotkb:Q0E973|uniprotkb:Q0E974|uniprotkb:Q8MT38|uniprotkb:Q9GSZ3	psi-mi:numb_drome(display_long)|uniprotkb:CG3779(orf name)|uniprotkb:numb(gene name)|psi-mi:numb(display_short)	psi-mi:apkc_drome(display_long)|uniprotkb:aPKC(gene name)|psi-mi:aPKC(display_short)|uniprotkb:CG30475(orf name)	psi-mi:"MI:0096"(pull down)	Wirtz-Peitz et al. (2008)	imex:IM-12136|pubmed:18854163	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2027251|imex:IM-12136-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_523523.2|refseq:NP_723460.1|flybase:FBgn0002973|refseq:NP_001260291.1|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051642"(centrosome localization)|go:"GO:0051960"(regulation of nervous system development)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0061320"(pericardial nephrocyte differentiation)|go:"GO:0061382"(Malpighian tubule tip cell differentiation)|go:"GO:1902692"(regulation of neuroblast proliferation)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR010449(NUMB phenylalanine-rich)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016698(Numb/numb-like)|mint:P16554|go:"GO:0045178"(basal part of cell)|rcsb pdb:1DDM|rcsb pdb:2NMB|rcsb pdb:5YI7|rcsb pdb:5YI8|reactome:R-DME-5610780|reactome:R-DME-5632684|ensemblmetazoa:FBgn0002973(gene)|ensemblmetazoa:FBtr0079822(transcript)|ensemblmetazoa:FBtr0339526(transcript)|go:"GO:0001920"(negative regulation of receptor recycling)|go:"GO:0005112"(Notch binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0008104"(protein localization)|go:"GO:0008347"(glial cell migration)|go:"GO:0009786"(regulation of asymmetric cell division)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014019"(neuroblast development)|go:"GO:0016360"(sensory organ precursor cell fate determination)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0042694"(muscle cell fate specification)|go:"GO:0045035"(sensory organ precursor cell division)	refseq:NP_001036541.1|refseq:NP_524892.2|flybase:FBgn0261854|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0045176"(apical protein localization)|go:"GO:0045179"(apical cortex)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0045196"(establishment or maintenance of neuroblast polarity)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0046667"(compound eye retinal cell programmed cell death)|go:"GO:0046872"(metal ion binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051601"(exocyst localization)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090163"(establishment of epithelial cell planar polarity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140591"(nuclear envelope budding)|go:"GO:1904580"(regulation of intracellular mRNA localization)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012233(Protein kinase C, zeta/iota)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:0035331"(negative regulation of hippo signaling)|ensemblmetazoa:FBgn0261854(gene)|ensemblmetazoa:FBtr0303430(transcript)|ensemblmetazoa:FBtr0303434(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007294"(germarium-derived oocyte fate determination)|go:"GO:0007314"(oocyte anterior/posterior axis specification)|go:"GO:0007416"(synapse assembly)|go:"GO:0007423"(sensory organ development)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0007613"(memory)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016332"(establishment or maintenance of polarity of embryonic epithelium)|go:"GO:0016334"(establishment or maintenance of polarity of follicular epithelium)|go:"GO:0017022"(myosin binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030860"(regulation of polarized epithelial cell differentiation)|go:"GO:0034332"(adherens junction organization)|go:"GO:0035003"(subapical complex)|go:"GO:0035011"(melanotic encapsulation of foreign target)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034659|interpro:IPR034877|reactome:R-DME-2173791|reactome:R-DME-5218921|reactome:R-DME-9634635|refseq:NP_001036542.1|refseq:NP_001036543.1|refseq:NP_001036544.1|refseq:NP_001036545.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 6B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/11/04	2014/10/16	rogid:9FGhbcAA6k1LCDHPoLSXwEEVwzY7227	rogid:w7Lc8l4/50NKAWamwS+Lzk6lbgA7227	intact-crc:5C47E11116A52D64|rigid:sft2HJ4Il0OgWH6DJ3a8BnEtcQM	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P16554	uniprotkb:O97111	intact:EBI-429581|uniprotkb:Q8IPE9|uniprotkb:Q961A6|uniprotkb:Q9VLB8|uniprotkb:B8A413|uniprotkb:B8A419|ensemblmetazoa:FBpp0079420|ensemblmetazoa:FBpp0308609	intact:EBI-186645|ensemblmetazoa:FBpp0074229|ensemblmetazoa:FBpp0074230	psi-mi:numb_drome(display_long)|uniprotkb:CG3779(orf name)|uniprotkb:numb(gene name)|psi-mi:numb(display_short)	psi-mi:o97111_drome(display_long)|uniprotkb:par-6(gene name)|psi-mi:par-6(display_short)|uniprotkb:DPar-6(gene name synonym)|uniprotkb:DPar6(gene name synonym)|uniprotkb:Dm-Par-6(gene name synonym)|uniprotkb:Dm-Par6(gene name synonym)|uniprotkb:DmPAR-6(gene name synonym)|uniprotkb:DmPar-6(gene name synonym)|uniprotkb:DmPar6(gene name synonym)|uniprotkb:Dmel\CG5884(gene name synonym)|uniprotkb:Dmpar6(gene name synonym)|uniprotkb:PAR-6(gene name synonym)|uniprotkb:PAR6(gene name synonym)|uniprotkb:Par(gene name synonym)|uniprotkb:Par-6(gene name synonym)|uniprotkb:Par6(gene name synonym)|uniprotkb:dPAR-6(gene name synonym)|uniprotkb:dPar-6(gene name synonym)|uniprotkb:dmPar-6(gene name synonym)|uniprotkb:par(gene name synonym)|uniprotkb:par6(gene name synonym)|uniprotkb:Dmel_CG5884(orf name)|uniprotkb:CG5884(orf name)	psi-mi:"MI:0096"(pull down)	Wirtz-Peitz et al. (2008)	imex:IM-12136|pubmed:18854163	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2027251|imex:IM-12136-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_523523.2|refseq:NP_723460.1|flybase:FBgn0002973|refseq:NP_001260291.1|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051642"(centrosome localization)|go:"GO:0051960"(regulation of nervous system development)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0061320"(pericardial nephrocyte differentiation)|go:"GO:0061382"(Malpighian tubule tip cell differentiation)|go:"GO:1902692"(regulation of neuroblast proliferation)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR010449(NUMB phenylalanine-rich)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016698(Numb/numb-like)|mint:P16554|go:"GO:0045178"(basal part of cell)|rcsb pdb:1DDM|rcsb pdb:2NMB|rcsb pdb:5YI7|rcsb pdb:5YI8|reactome:R-DME-5610780|reactome:R-DME-5632684|ensemblmetazoa:FBgn0002973(gene)|ensemblmetazoa:FBtr0079822(transcript)|ensemblmetazoa:FBtr0339526(transcript)|go:"GO:0001920"(negative regulation of receptor recycling)|go:"GO:0005112"(Notch binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0008104"(protein localization)|go:"GO:0008347"(glial cell migration)|go:"GO:0009786"(regulation of asymmetric cell division)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014019"(neuroblast development)|go:"GO:0016360"(sensory organ precursor cell fate determination)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0042694"(muscle cell fate specification)|go:"GO:0045035"(sensory organ precursor cell division)	refseq:NP_573238.1|flybase:FBgn0026192|refseq:NP_728094.1|dip:DIP-17759N|ensemblmetazoa:FBgn0026192(gene)|ensemblmetazoa:FBtr0074455(transcript)|ensemblmetazoa:FBtr0074456(transcript)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007416"(synapse assembly)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016332"(establishment or maintenance of polarity of embryonic epithelium)|go:"GO:0035003"(subapical complex)|go:"GO:0043195"(terminal bouton)|go:"GO:0045176"(apical protein localization)|go:"GO:0045179"(apical cortex)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0045196"(establishment or maintenance of neuroblast polarity)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045200"(establishment of neuroblast polarity)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0060341"(regulation of cellular localization)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0097482"(muscle cell postsynaptic specialization)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR034868|interpro:IPR034873|interpro:IPR036034|rcsb pdb:1RY4|rcsb pdb:1RZX|rcsb pdb:1X8S|rcsb pdb:2LC6|rcsb pdb:2LC7|rcsb pdb:5I7Z|reactome:R-DME-2173791|reactome:R-DME-4608870|reactome:R-DME-9013149	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 6B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/11/04	2014/10/16	rogid:9FGhbcAA6k1LCDHPoLSXwEEVwzY7227	rogid:L8COGHmbjA0Br5eyBQPvEeCEQTw7227	intact-crc:5C47E11116A52D64|rigid:sft2HJ4Il0OgWH6DJ3a8BnEtcQM	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P16554	uniprotkb:O96782	intact:EBI-429581|uniprotkb:Q8IPE9|uniprotkb:Q961A6|uniprotkb:Q9VLB8|uniprotkb:B8A413|uniprotkb:B8A419|ensemblmetazoa:FBpp0079420|ensemblmetazoa:FBpp0308609	intact:EBI-867941	psi-mi:numb_drome(display_long)|uniprotkb:CG3779(orf name)|uniprotkb:numb(gene name)|psi-mi:numb(display_short)	psi-mi:o96782_drome(display_long)|uniprotkb:baz(gene name)|psi-mi:baz(display_short)|uniprotkb:bazooka(gene name synonym)|uniprotkb:CG5055(orf name)	psi-mi:"MI:0096"(pull down)	Wirtz-Peitz et al. (2008)	imex:IM-12136|pubmed:18854163	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2027251|imex:IM-12136-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_523523.2|refseq:NP_723460.1|flybase:FBgn0002973|refseq:NP_001260291.1|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051642"(centrosome localization)|go:"GO:0051960"(regulation of nervous system development)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0061320"(pericardial nephrocyte differentiation)|go:"GO:0061382"(Malpighian tubule tip cell differentiation)|go:"GO:1902692"(regulation of neuroblast proliferation)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR010449(NUMB phenylalanine-rich)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016698(Numb/numb-like)|mint:P16554|go:"GO:0045178"(basal part of cell)|rcsb pdb:1DDM|rcsb pdb:2NMB|rcsb pdb:5YI7|rcsb pdb:5YI8|reactome:R-DME-5610780|reactome:R-DME-5632684|ensemblmetazoa:FBgn0002973(gene)|ensemblmetazoa:FBtr0079822(transcript)|ensemblmetazoa:FBtr0339526(transcript)|go:"GO:0001920"(negative regulation of receptor recycling)|go:"GO:0005112"(Notch binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0008104"(protein localization)|go:"GO:0008347"(glial cell migration)|go:"GO:0009786"(regulation of asymmetric cell division)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014019"(neuroblast development)|go:"GO:0016360"(sensory organ precursor cell fate determination)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0042694"(muscle cell fate specification)|go:"GO:0045035"(sensory organ precursor cell division)	flybase:FBgn0000163|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005912"(adherens junction)|go:"GO:0005914"(spot adherens junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0005938"(cell cortex)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007294"(germarium-derived oocyte fate determination)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007299"(ovarian follicle cell-cell adhesion)|go:"GO:0007314"(oocyte anterior/posterior axis specification)|go:"GO:0007377"(germ-band extension)|go:"GO:0007416"(synapse assembly)|go:"GO:0008104"(protein localization)|go:"GO:0008594"(photoreceptor cell morphogenesis)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016325"(oocyte microtubule cytoskeleton organization)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030709"(border follicle cell delamination)|go:"GO:0035089"(establishment of apical/basal cell polarity)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0051490"(negative regulation of filopodium assembly)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0072002"(Malpighian tubule development)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR021922|interpro:IPR036034|mint:O96782	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 6B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/11/04	2014/10/16	rogid:9FGhbcAA6k1LCDHPoLSXwEEVwzY7227	rogid:UT2HtbwNRFuGCQL1dHzbkIBnJe47227	intact-crc:5C47E11116A52D64|rigid:sft2HJ4Il0OgWH6DJ3a8BnEtcQM	false	glutathione s tranferase tag:?-?	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O97111	uniprotkb:P08111	intact:EBI-186645|ensemblmetazoa:FBpp0074229|ensemblmetazoa:FBpp0074230	intact:EBI-497569|uniprotkb:Q0E8V5|uniprotkb:Q24377|uniprotkb:D0IQ91|uniprotkb:D0IQJ0|uniprotkb:Q8IPV4|uniprotkb:Q8IPV5|uniprotkb:Q9VPI1|uniprotkb:A4UZW0|ensemblmetazoa:FBpp0077828|ensemblmetazoa:FBpp0077829|ensemblmetazoa:FBpp0297544|ensemblmetazoa:FBpp0297545|ensemblmetazoa:FBpp0297546|ensemblmetazoa:FBpp0297547	psi-mi:o97111_drome(display_long)|uniprotkb:par-6(gene name)|psi-mi:par-6(display_short)|uniprotkb:DPar-6(gene name synonym)|uniprotkb:DPar6(gene name synonym)|uniprotkb:Dm-Par-6(gene name synonym)|uniprotkb:Dm-Par6(gene name synonym)|uniprotkb:DmPAR-6(gene name synonym)|uniprotkb:DmPar-6(gene name synonym)|uniprotkb:DmPar6(gene name synonym)|uniprotkb:Dmel\CG5884(gene name synonym)|uniprotkb:Dmpar6(gene name synonym)|uniprotkb:PAR-6(gene name synonym)|uniprotkb:PAR6(gene name synonym)|uniprotkb:Par(gene name synonym)|uniprotkb:Par-6(gene name synonym)|uniprotkb:Par6(gene name synonym)|uniprotkb:dPAR-6(gene name synonym)|uniprotkb:dPar-6(gene name synonym)|uniprotkb:dmPar-6(gene name synonym)|uniprotkb:par(gene name synonym)|uniprotkb:par6(gene name synonym)|uniprotkb:Dmel_CG5884(orf name)|uniprotkb:CG5884(orf name)	psi-mi:l2gl_drome(display_long)|uniprotkb:"l(2)gl"(gene name)|psi-mi:"l(2)gl"(display_short)|uniprotkb:CG2671(orf name)	psi-mi:"MI:0096"(pull down)	Wirtz-Peitz et al. (2008)	imex:IM-12136|pubmed:18854163	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2027283|imex:IM-12136-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_573238.1|flybase:FBgn0026192|refseq:NP_728094.1|dip:DIP-17759N|ensemblmetazoa:FBgn0026192(gene)|ensemblmetazoa:FBtr0074455(transcript)|ensemblmetazoa:FBtr0074456(transcript)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007416"(synapse assembly)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016332"(establishment or maintenance of polarity of embryonic epithelium)|go:"GO:0035003"(subapical complex)|go:"GO:0043195"(terminal bouton)|go:"GO:0045176"(apical protein localization)|go:"GO:0045179"(apical cortex)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0045196"(establishment or maintenance of neuroblast polarity)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045200"(establishment of neuroblast polarity)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0060341"(regulation of cellular localization)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0097482"(muscle cell postsynaptic specialization)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR034868|interpro:IPR034873|interpro:IPR036034|rcsb pdb:1RY4|rcsb pdb:1RZX|rcsb pdb:1X8S|rcsb pdb:2LC6|rcsb pdb:2LC7|rcsb pdb:5I7Z|reactome:R-DME-2173791|reactome:R-DME-4608870|reactome:R-DME-9013149	refseq:NP_523439.2|refseq:NP_722583.1|refseq:NP_722584.1|refseq:NP_722585.1|refseq:NP_722586.1|refseq:NP_722587.1|flybase:FBgn0002121|refseq:NP_001245801.1|refseq:NP_001245802.1|refseq:NP_001245803.1|refseq:NP_001245804.1|dip:DIP-22687N|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005920"(smooth septate junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006887"(exocytosis)|go:"GO:0007314"(oocyte anterior/posterior axis specification)|go:"GO:0007391"(dorsal closure)|go:"GO:0007399"(nervous system development)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007423"(sensory organ development)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0016325"(oocyte microtubule cytoskeleton organization)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016333"(morphogenesis of follicular epithelium)|go:"GO:0016334"(establishment or maintenance of polarity of follicular epithelium)|go:"GO:0016360"(sensory organ precursor cell fate determination)|go:"GO:0017022"(myosin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0019991"(septate junction assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031256"(leading edge membrane)|go:"GO:0032878"(regulation of establishment or maintenance of cell polarity)|go:"GO:0035070"(salivary gland histolysis)|go:"GO:0035072"(ecdysone-mediated induction of salivary gland cell autophagic cell death)|go:"GO:0035212"(cell competition in a multicellular organism)|go:"GO:0035293"(chitin-based larval cuticle pattern formation)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0045159"(myosin II binding)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0045175"(basal protein localization)|go:"GO:0045176"(apical protein localization)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045196"(establishment or maintenance of neuroblast polarity)|go:"GO:0045464"(R8 cell fate specification)|go:"GO:0045571"(negative regulation of imaginal disc growth)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048730"(epidermis morphogenesis)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0051294"(establishment of spindle orientation)|go:"GO:0051668"(localization within membrane)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0072697"(protein localization to cell cortex)|go:"GO:0090163"(establishment of epithelial cell planar polarity)|go:"GO:0098725"(symmetric cell division)|go:"GO:1904580"(regulation of intracellular mRNA localization)|interpro:IPR000664("Lethal(2) giant larvae protein")|interpro:IPR013577(Lethal giant larvae homologue 2)|interpro:IPR013905("Lethal giant larvae (Lgl) like, C-terminal")|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|ensemblmetazoa:FBgn0002121(gene)|ensemblmetazoa:FBtr0078170(transcript)|ensemblmetazoa:FBtr0078171(transcript)|ensemblmetazoa:FBtr0306589(transcript)|ensemblmetazoa:FBtr0306590(transcript)|ensemblmetazoa:FBtr0306591(transcript)|ensemblmetazoa:FBtr0306592(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0004860"(protein kinase inhibitor activity)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 6B, Supp. Fig. 7A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/11/04	2014/10/16	rogid:L8COGHmbjA0Br5eyBQPvEeCEQTw7227	rogid:wMEqgAEqWRfMWlyvB1PjKBJ/vuI7227	intact-crc:ADB16AB05777DA6A|rigid:kuxWVAIsOyCUGOorUzjVpXYV7I8	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O97111	uniprotkb:O96782	intact:EBI-186645|ensemblmetazoa:FBpp0074229|ensemblmetazoa:FBpp0074230	intact:EBI-867941	psi-mi:o97111_drome(display_long)|uniprotkb:par-6(gene name)|psi-mi:par-6(display_short)|uniprotkb:DPar-6(gene name synonym)|uniprotkb:DPar6(gene name synonym)|uniprotkb:Dm-Par-6(gene name synonym)|uniprotkb:Dm-Par6(gene name synonym)|uniprotkb:DmPAR-6(gene name synonym)|uniprotkb:DmPar-6(gene name synonym)|uniprotkb:DmPar6(gene name synonym)|uniprotkb:Dmel\CG5884(gene name synonym)|uniprotkb:Dmpar6(gene name synonym)|uniprotkb:PAR-6(gene name synonym)|uniprotkb:PAR6(gene name synonym)|uniprotkb:Par(gene name synonym)|uniprotkb:Par-6(gene name synonym)|uniprotkb:Par6(gene name synonym)|uniprotkb:dPAR-6(gene name synonym)|uniprotkb:dPar-6(gene name synonym)|uniprotkb:dmPar-6(gene name synonym)|uniprotkb:par(gene name synonym)|uniprotkb:par6(gene name synonym)|uniprotkb:Dmel_CG5884(orf name)|uniprotkb:CG5884(orf name)	psi-mi:o96782_drome(display_long)|uniprotkb:baz(gene name)|psi-mi:baz(display_short)|uniprotkb:bazooka(gene name synonym)|uniprotkb:CG5055(orf name)	psi-mi:"MI:0096"(pull down)	Wirtz-Peitz et al. (2008)	imex:IM-12136|pubmed:18854163	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2027283|imex:IM-12136-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_573238.1|flybase:FBgn0026192|refseq:NP_728094.1|dip:DIP-17759N|ensemblmetazoa:FBgn0026192(gene)|ensemblmetazoa:FBtr0074455(transcript)|ensemblmetazoa:FBtr0074456(transcript)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007416"(synapse assembly)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016332"(establishment or maintenance of polarity of embryonic epithelium)|go:"GO:0035003"(subapical complex)|go:"GO:0043195"(terminal bouton)|go:"GO:0045176"(apical protein localization)|go:"GO:0045179"(apical cortex)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0045196"(establishment or maintenance of neuroblast polarity)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045200"(establishment of neuroblast polarity)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0060341"(regulation of cellular localization)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0097482"(muscle cell postsynaptic specialization)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR034868|interpro:IPR034873|interpro:IPR036034|rcsb pdb:1RY4|rcsb pdb:1RZX|rcsb pdb:1X8S|rcsb pdb:2LC6|rcsb pdb:2LC7|rcsb pdb:5I7Z|reactome:R-DME-2173791|reactome:R-DME-4608870|reactome:R-DME-9013149	flybase:FBgn0000163|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005912"(adherens junction)|go:"GO:0005914"(spot adherens junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0005938"(cell cortex)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007294"(germarium-derived oocyte fate determination)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007299"(ovarian follicle cell-cell adhesion)|go:"GO:0007314"(oocyte anterior/posterior axis specification)|go:"GO:0007377"(germ-band extension)|go:"GO:0007416"(synapse assembly)|go:"GO:0008104"(protein localization)|go:"GO:0008594"(photoreceptor cell morphogenesis)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016325"(oocyte microtubule cytoskeleton organization)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030709"(border follicle cell delamination)|go:"GO:0035089"(establishment of apical/basal cell polarity)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0051490"(negative regulation of filopodium assembly)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0072002"(Malpighian tubule development)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR021922|interpro:IPR036034|mint:O96782	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 6B, Supp. Fig. 7A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/11/04	2014/10/16	rogid:L8COGHmbjA0Br5eyBQPvEeCEQTw7227	rogid:UT2HtbwNRFuGCQL1dHzbkIBnJe47227	intact-crc:ADB16AB05777DA6A|rigid:kuxWVAIsOyCUGOorUzjVpXYV7I8	false	glutathione s tranferase tag:?-?	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O97111	uniprotkb:A1Z9X0	intact:EBI-186645|ensemblmetazoa:FBpp0074229|ensemblmetazoa:FBpp0074230	intact:EBI-160861|ensemblmetazoa:FBpp0292487|ensemblmetazoa:FBpp0292491|intact:EBI-2296820|intact:EBI-867915|intact:EBI-2027110|intact:EBI-2656028|uniprotkb:Q0E971|uniprotkb:Q0E972|uniprotkb:Q0E973|uniprotkb:Q0E974|uniprotkb:Q8MT38|uniprotkb:Q9GSZ3	psi-mi:o97111_drome(display_long)|uniprotkb:par-6(gene name)|psi-mi:par-6(display_short)|uniprotkb:DPar-6(gene name synonym)|uniprotkb:DPar6(gene name synonym)|uniprotkb:Dm-Par-6(gene name synonym)|uniprotkb:Dm-Par6(gene name synonym)|uniprotkb:DmPAR-6(gene name synonym)|uniprotkb:DmPar-6(gene name synonym)|uniprotkb:DmPar6(gene name synonym)|uniprotkb:Dmel\CG5884(gene name synonym)|uniprotkb:Dmpar6(gene name synonym)|uniprotkb:PAR-6(gene name synonym)|uniprotkb:PAR6(gene name synonym)|uniprotkb:Par(gene name synonym)|uniprotkb:Par-6(gene name synonym)|uniprotkb:Par6(gene name synonym)|uniprotkb:dPAR-6(gene name synonym)|uniprotkb:dPar-6(gene name synonym)|uniprotkb:dmPar-6(gene name synonym)|uniprotkb:par(gene name synonym)|uniprotkb:par6(gene name synonym)|uniprotkb:Dmel_CG5884(orf name)|uniprotkb:CG5884(orf name)	psi-mi:apkc_drome(display_long)|uniprotkb:aPKC(gene name)|psi-mi:aPKC(display_short)|uniprotkb:CG30475(orf name)	psi-mi:"MI:0096"(pull down)	Wirtz-Peitz et al. (2008)	imex:IM-12136|pubmed:18854163	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2027283|imex:IM-12136-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_573238.1|flybase:FBgn0026192|refseq:NP_728094.1|dip:DIP-17759N|ensemblmetazoa:FBgn0026192(gene)|ensemblmetazoa:FBtr0074455(transcript)|ensemblmetazoa:FBtr0074456(transcript)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007416"(synapse assembly)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016332"(establishment or maintenance of polarity of embryonic epithelium)|go:"GO:0035003"(subapical complex)|go:"GO:0043195"(terminal bouton)|go:"GO:0045176"(apical protein localization)|go:"GO:0045179"(apical cortex)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0045196"(establishment or maintenance of neuroblast polarity)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045200"(establishment of neuroblast polarity)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0060341"(regulation of cellular localization)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0097482"(muscle cell postsynaptic specialization)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR034868|interpro:IPR034873|interpro:IPR036034|rcsb pdb:1RY4|rcsb pdb:1RZX|rcsb pdb:1X8S|rcsb pdb:2LC6|rcsb pdb:2LC7|rcsb pdb:5I7Z|reactome:R-DME-2173791|reactome:R-DME-4608870|reactome:R-DME-9013149	refseq:NP_001036541.1|refseq:NP_524892.2|flybase:FBgn0261854|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0045176"(apical protein localization)|go:"GO:0045179"(apical cortex)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0045196"(establishment or maintenance of neuroblast polarity)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0046667"(compound eye retinal cell programmed cell death)|go:"GO:0046872"(metal ion binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051601"(exocyst localization)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090163"(establishment of epithelial cell planar polarity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140591"(nuclear envelope budding)|go:"GO:1904580"(regulation of intracellular mRNA localization)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012233(Protein kinase C, zeta/iota)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:0035331"(negative regulation of hippo signaling)|ensemblmetazoa:FBgn0261854(gene)|ensemblmetazoa:FBtr0303430(transcript)|ensemblmetazoa:FBtr0303434(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007294"(germarium-derived oocyte fate determination)|go:"GO:0007314"(oocyte anterior/posterior axis specification)|go:"GO:0007416"(synapse assembly)|go:"GO:0007423"(sensory organ development)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0007613"(memory)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016332"(establishment or maintenance of polarity of embryonic epithelium)|go:"GO:0016334"(establishment or maintenance of polarity of follicular epithelium)|go:"GO:0017022"(myosin binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030860"(regulation of polarized epithelial cell differentiation)|go:"GO:0034332"(adherens junction organization)|go:"GO:0035003"(subapical complex)|go:"GO:0035011"(melanotic encapsulation of foreign target)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034659|interpro:IPR034877|reactome:R-DME-2173791|reactome:R-DME-5218921|reactome:R-DME-9634635|refseq:NP_001036542.1|refseq:NP_001036543.1|refseq:NP_001036544.1|refseq:NP_001036545.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 6B, Supp. Fig. 7A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/11/04	2014/10/16	rogid:L8COGHmbjA0Br5eyBQPvEeCEQTw7227	rogid:w7Lc8l4/50NKAWamwS+Lzk6lbgA7227	intact-crc:ADB16AB05777DA6A|rigid:kuxWVAIsOyCUGOorUzjVpXYV7I8	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P16554	uniprotkb:O97111	intact:EBI-429581|uniprotkb:Q8IPE9|uniprotkb:Q961A6|uniprotkb:Q9VLB8|uniprotkb:B8A413|uniprotkb:B8A419|ensemblmetazoa:FBpp0079420|ensemblmetazoa:FBpp0308609	intact:EBI-186645|ensemblmetazoa:FBpp0074229|ensemblmetazoa:FBpp0074230	psi-mi:numb_drome(display_long)|uniprotkb:CG3779(orf name)|uniprotkb:numb(gene name)|psi-mi:numb(display_short)	psi-mi:o97111_drome(display_long)|uniprotkb:par-6(gene name)|psi-mi:par-6(display_short)|uniprotkb:DPar-6(gene name synonym)|uniprotkb:DPar6(gene name synonym)|uniprotkb:Dm-Par-6(gene name synonym)|uniprotkb:Dm-Par6(gene name synonym)|uniprotkb:DmPAR-6(gene name synonym)|uniprotkb:DmPar-6(gene name synonym)|uniprotkb:DmPar6(gene name synonym)|uniprotkb:Dmel\CG5884(gene name synonym)|uniprotkb:Dmpar6(gene name synonym)|uniprotkb:PAR-6(gene name synonym)|uniprotkb:PAR6(gene name synonym)|uniprotkb:Par(gene name synonym)|uniprotkb:Par-6(gene name synonym)|uniprotkb:Par6(gene name synonym)|uniprotkb:dPAR-6(gene name synonym)|uniprotkb:dPar-6(gene name synonym)|uniprotkb:dmPar-6(gene name synonym)|uniprotkb:par(gene name synonym)|uniprotkb:par6(gene name synonym)|uniprotkb:Dmel_CG5884(orf name)|uniprotkb:CG5884(orf name)	psi-mi:"MI:0096"(pull down)	Wirtz-Peitz et al. (2008)	imex:IM-12136|pubmed:18854163	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2027317|imex:IM-12136-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_523523.2|refseq:NP_723460.1|flybase:FBgn0002973|refseq:NP_001260291.1|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051642"(centrosome localization)|go:"GO:0051960"(regulation of nervous system development)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0061320"(pericardial nephrocyte differentiation)|go:"GO:0061382"(Malpighian tubule tip cell differentiation)|go:"GO:1902692"(regulation of neuroblast proliferation)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR010449(NUMB phenylalanine-rich)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016698(Numb/numb-like)|mint:P16554|go:"GO:0045178"(basal part of cell)|rcsb pdb:1DDM|rcsb pdb:2NMB|rcsb pdb:5YI7|rcsb pdb:5YI8|reactome:R-DME-5610780|reactome:R-DME-5632684|ensemblmetazoa:FBgn0002973(gene)|ensemblmetazoa:FBtr0079822(transcript)|ensemblmetazoa:FBtr0339526(transcript)|go:"GO:0001920"(negative regulation of receptor recycling)|go:"GO:0005112"(Notch binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0008104"(protein localization)|go:"GO:0008347"(glial cell migration)|go:"GO:0009786"(regulation of asymmetric cell division)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014019"(neuroblast development)|go:"GO:0016360"(sensory organ precursor cell fate determination)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0042694"(muscle cell fate specification)|go:"GO:0045035"(sensory organ precursor cell division)	refseq:NP_573238.1|flybase:FBgn0026192|refseq:NP_728094.1|dip:DIP-17759N|ensemblmetazoa:FBgn0026192(gene)|ensemblmetazoa:FBtr0074455(transcript)|ensemblmetazoa:FBtr0074456(transcript)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007416"(synapse assembly)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016332"(establishment or maintenance of polarity of embryonic epithelium)|go:"GO:0035003"(subapical complex)|go:"GO:0043195"(terminal bouton)|go:"GO:0045176"(apical protein localization)|go:"GO:0045179"(apical cortex)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0045196"(establishment or maintenance of neuroblast polarity)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045200"(establishment of neuroblast polarity)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0060341"(regulation of cellular localization)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0097482"(muscle cell postsynaptic specialization)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR034868|interpro:IPR034873|interpro:IPR036034|rcsb pdb:1RY4|rcsb pdb:1RZX|rcsb pdb:1X8S|rcsb pdb:2LC6|rcsb pdb:2LC7|rcsb pdb:5I7Z|reactome:R-DME-2173791|reactome:R-DME-4608870|reactome:R-DME-9013149	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 6C|comment:Numb Ser52Phe failed to precipitate Baz and bound only minor amounts of Par-6 and aPKC.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/11/04	2014/10/16	rogid:9FGhbcAA6k1LCDHPoLSXwEEVwzY7227	rogid:L8COGHmbjA0Br5eyBQPvEeCEQTw7227	intact-crc:29607912905CD505|rigid:W4cMIdUQj7CsFKkVrTebungkXoU	false	glutathione s tranferase tag:?-?|mutation decreasing interaction:52-52	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P16554	uniprotkb:A1Z9X0	intact:EBI-429581|uniprotkb:Q8IPE9|uniprotkb:Q961A6|uniprotkb:Q9VLB8|uniprotkb:B8A413|uniprotkb:B8A419|ensemblmetazoa:FBpp0079420|ensemblmetazoa:FBpp0308609	intact:EBI-160861|ensemblmetazoa:FBpp0292487|ensemblmetazoa:FBpp0292491|intact:EBI-2296820|intact:EBI-867915|intact:EBI-2027110|intact:EBI-2656028|uniprotkb:Q0E971|uniprotkb:Q0E972|uniprotkb:Q0E973|uniprotkb:Q0E974|uniprotkb:Q8MT38|uniprotkb:Q9GSZ3	psi-mi:numb_drome(display_long)|uniprotkb:CG3779(orf name)|uniprotkb:numb(gene name)|psi-mi:numb(display_short)	psi-mi:apkc_drome(display_long)|uniprotkb:aPKC(gene name)|psi-mi:aPKC(display_short)|uniprotkb:CG30475(orf name)	psi-mi:"MI:0096"(pull down)	Wirtz-Peitz et al. (2008)	imex:IM-12136|pubmed:18854163	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2027317|imex:IM-12136-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_523523.2|refseq:NP_723460.1|flybase:FBgn0002973|refseq:NP_001260291.1|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051642"(centrosome localization)|go:"GO:0051960"(regulation of nervous system development)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0061320"(pericardial nephrocyte differentiation)|go:"GO:0061382"(Malpighian tubule tip cell differentiation)|go:"GO:1902692"(regulation of neuroblast proliferation)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR010449(NUMB phenylalanine-rich)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016698(Numb/numb-like)|mint:P16554|go:"GO:0045178"(basal part of cell)|rcsb pdb:1DDM|rcsb pdb:2NMB|rcsb pdb:5YI7|rcsb pdb:5YI8|reactome:R-DME-5610780|reactome:R-DME-5632684|ensemblmetazoa:FBgn0002973(gene)|ensemblmetazoa:FBtr0079822(transcript)|ensemblmetazoa:FBtr0339526(transcript)|go:"GO:0001920"(negative regulation of receptor recycling)|go:"GO:0005112"(Notch binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0008104"(protein localization)|go:"GO:0008347"(glial cell migration)|go:"GO:0009786"(regulation of asymmetric cell division)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014019"(neuroblast development)|go:"GO:0016360"(sensory organ precursor cell fate determination)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0042694"(muscle cell fate specification)|go:"GO:0045035"(sensory organ precursor cell division)	refseq:NP_001036541.1|refseq:NP_524892.2|flybase:FBgn0261854|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0045176"(apical protein localization)|go:"GO:0045179"(apical cortex)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0045196"(establishment or maintenance of neuroblast polarity)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0046667"(compound eye retinal cell programmed cell death)|go:"GO:0046872"(metal ion binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051601"(exocyst localization)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090163"(establishment of epithelial cell planar polarity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140591"(nuclear envelope budding)|go:"GO:1904580"(regulation of intracellular mRNA localization)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012233(Protein kinase C, zeta/iota)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:0035331"(negative regulation of hippo signaling)|ensemblmetazoa:FBgn0261854(gene)|ensemblmetazoa:FBtr0303430(transcript)|ensemblmetazoa:FBtr0303434(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007294"(germarium-derived oocyte fate determination)|go:"GO:0007314"(oocyte anterior/posterior axis specification)|go:"GO:0007416"(synapse assembly)|go:"GO:0007423"(sensory organ development)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0007613"(memory)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016332"(establishment or maintenance of polarity of embryonic epithelium)|go:"GO:0016334"(establishment or maintenance of polarity of follicular epithelium)|go:"GO:0017022"(myosin binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030860"(regulation of polarized epithelial cell differentiation)|go:"GO:0034332"(adherens junction organization)|go:"GO:0035003"(subapical complex)|go:"GO:0035011"(melanotic encapsulation of foreign target)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034659|interpro:IPR034877|reactome:R-DME-2173791|reactome:R-DME-5218921|reactome:R-DME-9634635|refseq:NP_001036542.1|refseq:NP_001036543.1|refseq:NP_001036544.1|refseq:NP_001036545.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 6C|comment:Numb Ser52Phe failed to precipitate Baz and bound only minor amounts of Par-6 and aPKC.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/11/04	2014/10/16	rogid:9FGhbcAA6k1LCDHPoLSXwEEVwzY7227	rogid:w7Lc8l4/50NKAWamwS+Lzk6lbgA7227	intact-crc:29607912905CD505|rigid:W4cMIdUQj7CsFKkVrTebungkXoU	false	glutathione s tranferase tag:?-?|mutation decreasing interaction:52-52	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P16554	uniprotkb:P91926	intact:EBI-429581|uniprotkb:Q8IPE9|uniprotkb:Q961A6|uniprotkb:Q9VLB8|uniprotkb:B8A413|uniprotkb:B8A419|ensemblmetazoa:FBpp0079420|ensemblmetazoa:FBpp0308609	intact:EBI-183420|uniprotkb:O01937|uniprotkb:Q7KTZ5|uniprotkb:Q86P64|uniprotkb:Q9VPP4|uniprotkb:B3DN51|ensemblmetazoa:FBpp0088490	psi-mi:numb_drome(display_long)|uniprotkb:CG3779(orf name)|uniprotkb:numb(gene name)|psi-mi:numb(display_short)	psi-mi:ap2a_drome(display_long)|uniprotkb:AP-2alpha(gene name)|psi-mi:AP-2alpha(display_short)|uniprotkb:Alpha-adaptin(gene name synonym)|uniprotkb:CG4260(orf name)	psi-mi:"MI:0096"(pull down)	Wirtz-Peitz et al. (2008)	imex:IM-12136|pubmed:18854163	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2027317|imex:IM-12136-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_523523.2|refseq:NP_723460.1|flybase:FBgn0002973|refseq:NP_001260291.1|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051642"(centrosome localization)|go:"GO:0051960"(regulation of nervous system development)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0061320"(pericardial nephrocyte differentiation)|go:"GO:0061382"(Malpighian tubule tip cell differentiation)|go:"GO:1902692"(regulation of neuroblast proliferation)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR010449(NUMB phenylalanine-rich)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016698(Numb/numb-like)|mint:P16554|go:"GO:0045178"(basal part of cell)|rcsb pdb:1DDM|rcsb pdb:2NMB|rcsb pdb:5YI7|rcsb pdb:5YI8|reactome:R-DME-5610780|reactome:R-DME-5632684|ensemblmetazoa:FBgn0002973(gene)|ensemblmetazoa:FBtr0079822(transcript)|ensemblmetazoa:FBtr0339526(transcript)|go:"GO:0001920"(negative regulation of receptor recycling)|go:"GO:0005112"(Notch binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0008104"(protein localization)|go:"GO:0008347"(glial cell migration)|go:"GO:0009786"(regulation of asymmetric cell division)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014019"(neuroblast development)|go:"GO:0016360"(sensory organ precursor cell fate determination)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0042694"(muscle cell fate specification)|go:"GO:0045035"(sensory organ precursor cell division)	refseq:NP_476819.2|refseq:NP_995607.1|flybase:FBgn0264855|ensemblmetazoa:FBgn0264855(gene)|ensemblmetazoa:FBtr0089488(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008104"(protein localization)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0015031"(protein transport)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0031623"(receptor internalization)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0038010"(positive regulation of signal transduction by receptor internalization)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098793"(presynapse)|go:"GO:0140312"(cargo adaptor activity)|go:"GO:1990386"(mitotic cleavage furrow ingression)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR003164(Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017104(Adaptor protein complex AP-2, alpha subunit)|reactome:R-DME-177504|reactome:R-DME-3928665|reactome:R-DME-437239|reactome:R-DME-5099900|reactome:R-DME-5140745|reactome:R-DME-6798695|reactome:R-DME-8856825|reactome:R-DME-8856828|reactome:R-DME-8866427|reactome:R-DME-8964038	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 6C|comment:Numb Ser52Phe failed to precipitate Baz and bound only minor amounts of Par-6 and aPKC.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/11/04	2014/10/16	rogid:9FGhbcAA6k1LCDHPoLSXwEEVwzY7227	rogid:1kfuoodxtoNBOjXfMpYFk1SjWAA7227	intact-crc:29607912905CD505|rigid:W4cMIdUQj7CsFKkVrTebungkXoU	false	glutathione s tranferase tag:?-?|mutation decreasing interaction:52-52	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P16554	uniprotkb:O96782	intact:EBI-429581|uniprotkb:Q8IPE9|uniprotkb:Q961A6|uniprotkb:Q9VLB8|uniprotkb:B8A413|uniprotkb:B8A419|ensemblmetazoa:FBpp0079420|ensemblmetazoa:FBpp0308609	intact:EBI-867941	psi-mi:numb_drome(display_long)|uniprotkb:CG3779(orf name)|uniprotkb:numb(gene name)|psi-mi:numb(display_short)	psi-mi:o96782_drome(display_long)|uniprotkb:baz(gene name)|psi-mi:baz(display_short)|uniprotkb:bazooka(gene name synonym)|uniprotkb:CG5055(orf name)	psi-mi:"MI:0096"(pull down)	Wirtz-Peitz et al. (2008)	imex:IM-12136|pubmed:18854163	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2027317|imex:IM-12136-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_523523.2|refseq:NP_723460.1|flybase:FBgn0002973|refseq:NP_001260291.1|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051642"(centrosome localization)|go:"GO:0051960"(regulation of nervous system development)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0061320"(pericardial nephrocyte differentiation)|go:"GO:0061382"(Malpighian tubule tip cell differentiation)|go:"GO:1902692"(regulation of neuroblast proliferation)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR010449(NUMB phenylalanine-rich)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016698(Numb/numb-like)|mint:P16554|go:"GO:0045178"(basal part of cell)|rcsb pdb:1DDM|rcsb pdb:2NMB|rcsb pdb:5YI7|rcsb pdb:5YI8|reactome:R-DME-5610780|reactome:R-DME-5632684|ensemblmetazoa:FBgn0002973(gene)|ensemblmetazoa:FBtr0079822(transcript)|ensemblmetazoa:FBtr0339526(transcript)|go:"GO:0001920"(negative regulation of receptor recycling)|go:"GO:0005112"(Notch binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0008104"(protein localization)|go:"GO:0008347"(glial cell migration)|go:"GO:0009786"(regulation of asymmetric cell division)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014019"(neuroblast development)|go:"GO:0016360"(sensory organ precursor cell fate determination)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0042694"(muscle cell fate specification)|go:"GO:0045035"(sensory organ precursor cell division)	flybase:FBgn0000163|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005912"(adherens junction)|go:"GO:0005914"(spot adherens junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0005938"(cell cortex)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007294"(germarium-derived oocyte fate determination)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007299"(ovarian follicle cell-cell adhesion)|go:"GO:0007314"(oocyte anterior/posterior axis specification)|go:"GO:0007377"(germ-band extension)|go:"GO:0007416"(synapse assembly)|go:"GO:0008104"(protein localization)|go:"GO:0008594"(photoreceptor cell morphogenesis)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016325"(oocyte microtubule cytoskeleton organization)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030709"(border follicle cell delamination)|go:"GO:0035089"(establishment of apical/basal cell polarity)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0051490"(negative regulation of filopodium assembly)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0072002"(Malpighian tubule development)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR021922|interpro:IPR036034|mint:O96782	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 6C|comment:Numb Ser52Phe failed to precipitate Baz and bound only minor amounts of Par-6 and aPKC.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/11/04	2014/10/16	rogid:9FGhbcAA6k1LCDHPoLSXwEEVwzY7227	rogid:UT2HtbwNRFuGCQL1dHzbkIBnJe47227	intact-crc:29607912905CD505|rigid:W4cMIdUQj7CsFKkVrTebungkXoU	false	glutathione s tranferase tag:?-?|mutation decreasing interaction:52-52	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O96561	uniprotkb:P08111	intact:EBI-870379	intact:EBI-497569|uniprotkb:Q0E8V5|uniprotkb:Q24377|uniprotkb:D0IQ91|uniprotkb:D0IQJ0|uniprotkb:Q8IPV4|uniprotkb:Q8IPV5|uniprotkb:Q9VPI1|uniprotkb:A4UZW0|ensemblmetazoa:FBpp0077828|ensemblmetazoa:FBpp0077829|ensemblmetazoa:FBpp0297544|ensemblmetazoa:FBpp0297545|ensemblmetazoa:FBpp0297546|ensemblmetazoa:FBpp0297547	psi-mi:o96561_drome(display_long)|uniprotkb:pon(gene name)|psi-mi:pon(display_short)|uniprotkb:CG3346(orf name)	psi-mi:l2gl_drome(display_long)|uniprotkb:"l(2)gl"(gene name)|psi-mi:"l(2)gl"(display_short)|uniprotkb:CG2671(orf name)	psi-mi:"MI:0096"(pull down)	Wirtz-Peitz et al. (2008)	imex:IM-12136|pubmed:18854163	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2027355|imex:IM-12136-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	flybase:FBgn0025739|dip:DIP-46780N|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0045178"(basal part of cell)|go:"GO:0055059"(asymmetric neuroblast division)|rcsb pdb:5J19	refseq:NP_523439.2|refseq:NP_722583.1|refseq:NP_722584.1|refseq:NP_722585.1|refseq:NP_722586.1|refseq:NP_722587.1|flybase:FBgn0002121|refseq:NP_001245801.1|refseq:NP_001245802.1|refseq:NP_001245803.1|refseq:NP_001245804.1|dip:DIP-22687N|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005920"(smooth septate junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006887"(exocytosis)|go:"GO:0007314"(oocyte anterior/posterior axis specification)|go:"GO:0007391"(dorsal closure)|go:"GO:0007399"(nervous system development)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007423"(sensory organ development)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0016325"(oocyte microtubule cytoskeleton organization)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016333"(morphogenesis of follicular epithelium)|go:"GO:0016334"(establishment or maintenance of polarity of follicular epithelium)|go:"GO:0016360"(sensory organ precursor cell fate determination)|go:"GO:0017022"(myosin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0019991"(septate junction assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031256"(leading edge membrane)|go:"GO:0032878"(regulation of establishment or maintenance of cell polarity)|go:"GO:0035070"(salivary gland histolysis)|go:"GO:0035072"(ecdysone-mediated induction of salivary gland cell autophagic cell death)|go:"GO:0035212"(cell competition in a multicellular organism)|go:"GO:0035293"(chitin-based larval cuticle pattern formation)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0045159"(myosin II binding)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0045175"(basal protein localization)|go:"GO:0045176"(apical protein localization)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045196"(establishment or maintenance of neuroblast polarity)|go:"GO:0045464"(R8 cell fate specification)|go:"GO:0045571"(negative regulation of imaginal disc growth)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048730"(epidermis morphogenesis)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0051294"(establishment of spindle orientation)|go:"GO:0051668"(localization within membrane)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0072697"(protein localization to cell cortex)|go:"GO:0090163"(establishment of epithelial cell planar polarity)|go:"GO:0098725"(symmetric cell division)|go:"GO:1904580"(regulation of intracellular mRNA localization)|interpro:IPR000664("Lethal(2) giant larvae protein")|interpro:IPR013577(Lethal giant larvae homologue 2)|interpro:IPR013905("Lethal giant larvae (Lgl) like, C-terminal")|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|ensemblmetazoa:FBgn0002121(gene)|ensemblmetazoa:FBtr0078170(transcript)|ensemblmetazoa:FBtr0078171(transcript)|ensemblmetazoa:FBtr0306589(transcript)|ensemblmetazoa:FBtr0306590(transcript)|ensemblmetazoa:FBtr0306591(transcript)|ensemblmetazoa:FBtr0306592(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0004860"(protein kinase inhibitor activity)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 7A|comment:"Coordinates of localisation domain of pon taken from PMID: 10635314"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/11/04	2014/10/16	rogid:UMAEAmrNpiQekl6kezCIIdfRjmI7227	rogid:wMEqgAEqWRfMWlyvB1PjKBJ/vuI7227	intact-crc:B831C921B1484C52|rigid:vzfv1UkZf13jh4cGab0EwJ1ydmQ	false	glutathione s tranferase tag:?-?|sufficient binding region:494-672	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O96561	uniprotkb:O97111	intact:EBI-870379	intact:EBI-186645|ensemblmetazoa:FBpp0074229|ensemblmetazoa:FBpp0074230	psi-mi:o96561_drome(display_long)|uniprotkb:pon(gene name)|psi-mi:pon(display_short)|uniprotkb:CG3346(orf name)	psi-mi:o97111_drome(display_long)|uniprotkb:par-6(gene name)|psi-mi:par-6(display_short)|uniprotkb:DPar-6(gene name synonym)|uniprotkb:DPar6(gene name synonym)|uniprotkb:Dm-Par-6(gene name synonym)|uniprotkb:Dm-Par6(gene name synonym)|uniprotkb:DmPAR-6(gene name synonym)|uniprotkb:DmPar-6(gene name synonym)|uniprotkb:DmPar6(gene name synonym)|uniprotkb:Dmel\CG5884(gene name synonym)|uniprotkb:Dmpar6(gene name synonym)|uniprotkb:PAR-6(gene name synonym)|uniprotkb:PAR6(gene name synonym)|uniprotkb:Par(gene name synonym)|uniprotkb:Par-6(gene name synonym)|uniprotkb:Par6(gene name synonym)|uniprotkb:dPAR-6(gene name synonym)|uniprotkb:dPar-6(gene name synonym)|uniprotkb:dmPar-6(gene name synonym)|uniprotkb:par(gene name synonym)|uniprotkb:par6(gene name synonym)|uniprotkb:Dmel_CG5884(orf name)|uniprotkb:CG5884(orf name)	psi-mi:"MI:0096"(pull down)	Wirtz-Peitz et al. (2008)	imex:IM-12136|pubmed:18854163	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2027355|imex:IM-12136-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	flybase:FBgn0025739|dip:DIP-46780N|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0045178"(basal part of cell)|go:"GO:0055059"(asymmetric neuroblast division)|rcsb pdb:5J19	refseq:NP_573238.1|flybase:FBgn0026192|refseq:NP_728094.1|dip:DIP-17759N|ensemblmetazoa:FBgn0026192(gene)|ensemblmetazoa:FBtr0074455(transcript)|ensemblmetazoa:FBtr0074456(transcript)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007416"(synapse assembly)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016332"(establishment or maintenance of polarity of embryonic epithelium)|go:"GO:0035003"(subapical complex)|go:"GO:0043195"(terminal bouton)|go:"GO:0045176"(apical protein localization)|go:"GO:0045179"(apical cortex)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0045196"(establishment or maintenance of neuroblast polarity)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045200"(establishment of neuroblast polarity)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0060341"(regulation of cellular localization)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0097482"(muscle cell postsynaptic specialization)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR034868|interpro:IPR034873|interpro:IPR036034|rcsb pdb:1RY4|rcsb pdb:1RZX|rcsb pdb:1X8S|rcsb pdb:2LC6|rcsb pdb:2LC7|rcsb pdb:5I7Z|reactome:R-DME-2173791|reactome:R-DME-4608870|reactome:R-DME-9013149	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 7A|comment:"Coordinates of localisation domain of pon taken from PMID: 10635314"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/11/04	2014/10/16	rogid:UMAEAmrNpiQekl6kezCIIdfRjmI7227	rogid:L8COGHmbjA0Br5eyBQPvEeCEQTw7227	intact-crc:B831C921B1484C52|rigid:vzfv1UkZf13jh4cGab0EwJ1ydmQ	false	glutathione s tranferase tag:?-?|sufficient binding region:494-672	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O96561	uniprotkb:O96782	intact:EBI-870379	intact:EBI-867941	psi-mi:o96561_drome(display_long)|uniprotkb:pon(gene name)|psi-mi:pon(display_short)|uniprotkb:CG3346(orf name)	psi-mi:o96782_drome(display_long)|uniprotkb:baz(gene name)|psi-mi:baz(display_short)|uniprotkb:bazooka(gene name synonym)|uniprotkb:CG5055(orf name)	psi-mi:"MI:0096"(pull down)	Wirtz-Peitz et al. (2008)	imex:IM-12136|pubmed:18854163	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2027355|imex:IM-12136-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	flybase:FBgn0025739|dip:DIP-46780N|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0045178"(basal part of cell)|go:"GO:0055059"(asymmetric neuroblast division)|rcsb pdb:5J19	flybase:FBgn0000163|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005912"(adherens junction)|go:"GO:0005914"(spot adherens junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0005938"(cell cortex)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007294"(germarium-derived oocyte fate determination)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007299"(ovarian follicle cell-cell adhesion)|go:"GO:0007314"(oocyte anterior/posterior axis specification)|go:"GO:0007377"(germ-band extension)|go:"GO:0007416"(synapse assembly)|go:"GO:0008104"(protein localization)|go:"GO:0008594"(photoreceptor cell morphogenesis)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016325"(oocyte microtubule cytoskeleton organization)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030709"(border follicle cell delamination)|go:"GO:0035089"(establishment of apical/basal cell polarity)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0051490"(negative regulation of filopodium assembly)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0072002"(Malpighian tubule development)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR021922|interpro:IPR036034|mint:O96782	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 7A|comment:"Coordinates of localisation domain of pon taken from PMID: 10635314"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/11/04	2014/10/16	rogid:UMAEAmrNpiQekl6kezCIIdfRjmI7227	rogid:UT2HtbwNRFuGCQL1dHzbkIBnJe47227	intact-crc:B831C921B1484C52|rigid:vzfv1UkZf13jh4cGab0EwJ1ydmQ	false	glutathione s tranferase tag:?-?|sufficient binding region:494-672	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O96561	uniprotkb:A1Z9X0	intact:EBI-870379	intact:EBI-160861|ensemblmetazoa:FBpp0292487|ensemblmetazoa:FBpp0292491|intact:EBI-2296820|intact:EBI-867915|intact:EBI-2027110|intact:EBI-2656028|uniprotkb:Q0E971|uniprotkb:Q0E972|uniprotkb:Q0E973|uniprotkb:Q0E974|uniprotkb:Q8MT38|uniprotkb:Q9GSZ3	psi-mi:o96561_drome(display_long)|uniprotkb:pon(gene name)|psi-mi:pon(display_short)|uniprotkb:CG3346(orf name)	psi-mi:apkc_drome(display_long)|uniprotkb:aPKC(gene name)|psi-mi:aPKC(display_short)|uniprotkb:CG30475(orf name)	psi-mi:"MI:0096"(pull down)	Wirtz-Peitz et al. (2008)	imex:IM-12136|pubmed:18854163	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2027355|imex:IM-12136-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	flybase:FBgn0025739|dip:DIP-46780N|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0045178"(basal part of cell)|go:"GO:0055059"(asymmetric neuroblast division)|rcsb pdb:5J19	refseq:NP_001036541.1|refseq:NP_524892.2|flybase:FBgn0261854|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0045176"(apical protein localization)|go:"GO:0045179"(apical cortex)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0045196"(establishment or maintenance of neuroblast polarity)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0046667"(compound eye retinal cell programmed cell death)|go:"GO:0046872"(metal ion binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051601"(exocyst localization)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090163"(establishment of epithelial cell planar polarity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140591"(nuclear envelope budding)|go:"GO:1904580"(regulation of intracellular mRNA localization)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012233(Protein kinase C, zeta/iota)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:0035331"(negative regulation of hippo signaling)|ensemblmetazoa:FBgn0261854(gene)|ensemblmetazoa:FBtr0303430(transcript)|ensemblmetazoa:FBtr0303434(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007294"(germarium-derived oocyte fate determination)|go:"GO:0007314"(oocyte anterior/posterior axis specification)|go:"GO:0007416"(synapse assembly)|go:"GO:0007423"(sensory organ development)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0007613"(memory)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016332"(establishment or maintenance of polarity of embryonic epithelium)|go:"GO:0016334"(establishment or maintenance of polarity of follicular epithelium)|go:"GO:0017022"(myosin binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030860"(regulation of polarized epithelial cell differentiation)|go:"GO:0034332"(adherens junction organization)|go:"GO:0035003"(subapical complex)|go:"GO:0035011"(melanotic encapsulation of foreign target)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034659|interpro:IPR034877|reactome:R-DME-2173791|reactome:R-DME-5218921|reactome:R-DME-9634635|refseq:NP_001036542.1|refseq:NP_001036543.1|refseq:NP_001036544.1|refseq:NP_001036545.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 7A|comment:"Coordinates of localisation domain of pon taken from PMID: 10635314"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/11/04	2014/10/16	rogid:UMAEAmrNpiQekl6kezCIIdfRjmI7227	rogid:w7Lc8l4/50NKAWamwS+Lzk6lbgA7227	intact-crc:B831C921B1484C52|rigid:vzfv1UkZf13jh4cGab0EwJ1ydmQ	false	glutathione s tranferase tag:?-?|sufficient binding region:494-672	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O44224	uniprotkb:P29617	intact:EBI-869852	intact:EBI-213350|uniprotkb:Q95SP0|uniprotkb:Q9U6A2|uniprotkb:Q9VGP8|uniprotkb:Q6AWI5|uniprotkb:A0A0B4K660|ensemblmetazoa:FBpp0293150	psi-mi:o44224_drome(display_long)|uniprotkb:mira(gene name)|psi-mi:mira(display_short)|uniprotkb:CG12249(orf name)	psi-mi:pros_drome(display_long)|uniprotkb:pros(gene name)|psi-mi:pros(display_short)|uniprotkb:CG17228(orf name)	psi-mi:"MI:0096"(pull down)	Wirtz-Peitz et al. (2008)	imex:IM-12136|pubmed:18854163	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2027376|imex:IM-12136-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	flybase:FBgn0021776|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005938"(cell cortex)|go:"GO:0007317"(regulation of pole plasm oskar mRNA localization)|go:"GO:0007400"(neuroblast fate determination)|go:"GO:0007402"(ganglion mother cell fate determination)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007419"(ventral cord development)|go:"GO:0008595"(anterior/posterior axis specification, embryo)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017022"(myosin binding)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0045178"(basal part of cell)|go:"GO:0045179"(apical cortex)|go:"GO:0045180"(basal cortex)|go:"GO:0048477"(oogenesis)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0072697"(protein localization to cell cortex)	refseq:NP_001247046.1|refseq:NP_524317.4|refseq:NP_731565.4|refseq:NP_788636.3|flybase:FBgn0004595|ensemblmetazoa:FBgn0004595(gene)|ensemblmetazoa:FBtr0304608(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0007402"(ganglion mother cell fate determination)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007409"(axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0007416"(synapse assembly)|go:"GO:0007417"(central nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0008049"(male courtship behavior)|go:"GO:0008104"(protein localization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014016"(neuroblast differentiation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045179"(apical cortex)|go:"GO:0045180"(basal cortex)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045676"(regulation of R7 cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0055060"(asymmetric neuroblast division resulting in ganglion mother cell formation)|go:"GO:0060385"(axonogenesis involved in innervation)|go:"GO:0061564"(axon development)|go:"GO:0070314"(G1 to G0 transition)|go:"GO:0070983"(dendrite guidance)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1902692"(regulation of neuroblast proliferation)|interpro:IPR009057(Homeodomain-like)|interpro:IPR023082|interpro:IPR037131|interpro:IPR039350|rcsb pdb:1MIJ|rcsb pdb:1XPX	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 7A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/11/04	2014/10/16	rogid:BJlUYvSh2EVnA0PxNbeFipc/S207227	rogid:xphiJOfb887AalCF1YoE2OD0DcQ7227	intact-crc:0E8FA0A4134DC7C9|rigid:KNAfTI6UOYaVtG219Kb7qoa8UK4	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O44224	uniprotkb:P08111	intact:EBI-869852	intact:EBI-497569|uniprotkb:Q0E8V5|uniprotkb:Q24377|uniprotkb:D0IQ91|uniprotkb:D0IQJ0|uniprotkb:Q8IPV4|uniprotkb:Q8IPV5|uniprotkb:Q9VPI1|uniprotkb:A4UZW0|ensemblmetazoa:FBpp0077828|ensemblmetazoa:FBpp0077829|ensemblmetazoa:FBpp0297544|ensemblmetazoa:FBpp0297545|ensemblmetazoa:FBpp0297546|ensemblmetazoa:FBpp0297547	psi-mi:o44224_drome(display_long)|uniprotkb:mira(gene name)|psi-mi:mira(display_short)|uniprotkb:CG12249(orf name)	psi-mi:l2gl_drome(display_long)|uniprotkb:"l(2)gl"(gene name)|psi-mi:"l(2)gl"(display_short)|uniprotkb:CG2671(orf name)	psi-mi:"MI:0096"(pull down)	Wirtz-Peitz et al. (2008)	imex:IM-12136|pubmed:18854163	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2027376|imex:IM-12136-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	flybase:FBgn0021776|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005938"(cell cortex)|go:"GO:0007317"(regulation of pole plasm oskar mRNA localization)|go:"GO:0007400"(neuroblast fate determination)|go:"GO:0007402"(ganglion mother cell fate determination)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007419"(ventral cord development)|go:"GO:0008595"(anterior/posterior axis specification, embryo)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017022"(myosin binding)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0045178"(basal part of cell)|go:"GO:0045179"(apical cortex)|go:"GO:0045180"(basal cortex)|go:"GO:0048477"(oogenesis)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0072697"(protein localization to cell cortex)	refseq:NP_523439.2|refseq:NP_722583.1|refseq:NP_722584.1|refseq:NP_722585.1|refseq:NP_722586.1|refseq:NP_722587.1|flybase:FBgn0002121|refseq:NP_001245801.1|refseq:NP_001245802.1|refseq:NP_001245803.1|refseq:NP_001245804.1|dip:DIP-22687N|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005920"(smooth septate junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006887"(exocytosis)|go:"GO:0007314"(oocyte anterior/posterior axis specification)|go:"GO:0007391"(dorsal closure)|go:"GO:0007399"(nervous system development)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007423"(sensory organ development)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0016325"(oocyte microtubule cytoskeleton organization)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016333"(morphogenesis of follicular epithelium)|go:"GO:0016334"(establishment or maintenance of polarity of follicular epithelium)|go:"GO:0016360"(sensory organ precursor cell fate determination)|go:"GO:0017022"(myosin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0019991"(septate junction assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031256"(leading edge membrane)|go:"GO:0032878"(regulation of establishment or maintenance of cell polarity)|go:"GO:0035070"(salivary gland histolysis)|go:"GO:0035072"(ecdysone-mediated induction of salivary gland cell autophagic cell death)|go:"GO:0035212"(cell competition in a multicellular organism)|go:"GO:0035293"(chitin-based larval cuticle pattern formation)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0045159"(myosin II binding)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0045175"(basal protein localization)|go:"GO:0045176"(apical protein localization)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045196"(establishment or maintenance of neuroblast polarity)|go:"GO:0045464"(R8 cell fate specification)|go:"GO:0045571"(negative regulation of imaginal disc growth)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048730"(epidermis morphogenesis)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0051294"(establishment of spindle orientation)|go:"GO:0051668"(localization within membrane)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0072697"(protein localization to cell cortex)|go:"GO:0090163"(establishment of epithelial cell planar polarity)|go:"GO:0098725"(symmetric cell division)|go:"GO:1904580"(regulation of intracellular mRNA localization)|interpro:IPR000664("Lethal(2) giant larvae protein")|interpro:IPR013577(Lethal giant larvae homologue 2)|interpro:IPR013905("Lethal giant larvae (Lgl) like, C-terminal")|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|ensemblmetazoa:FBgn0002121(gene)|ensemblmetazoa:FBtr0078170(transcript)|ensemblmetazoa:FBtr0078171(transcript)|ensemblmetazoa:FBtr0306589(transcript)|ensemblmetazoa:FBtr0306590(transcript)|ensemblmetazoa:FBtr0306591(transcript)|ensemblmetazoa:FBtr0306592(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0004860"(protein kinase inhibitor activity)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 7A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/11/04	2014/10/16	rogid:BJlUYvSh2EVnA0PxNbeFipc/S207227	rogid:wMEqgAEqWRfMWlyvB1PjKBJ/vuI7227	intact-crc:0E8FA0A4134DC7C9|rigid:KNAfTI6UOYaVtG219Kb7qoa8UK4	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O44224	uniprotkb:O97111	intact:EBI-869852	intact:EBI-186645|ensemblmetazoa:FBpp0074229|ensemblmetazoa:FBpp0074230	psi-mi:o44224_drome(display_long)|uniprotkb:mira(gene name)|psi-mi:mira(display_short)|uniprotkb:CG12249(orf name)	psi-mi:o97111_drome(display_long)|uniprotkb:par-6(gene name)|psi-mi:par-6(display_short)|uniprotkb:DPar-6(gene name synonym)|uniprotkb:DPar6(gene name synonym)|uniprotkb:Dm-Par-6(gene name synonym)|uniprotkb:Dm-Par6(gene name synonym)|uniprotkb:DmPAR-6(gene name synonym)|uniprotkb:DmPar-6(gene name synonym)|uniprotkb:DmPar6(gene name synonym)|uniprotkb:Dmel\CG5884(gene name synonym)|uniprotkb:Dmpar6(gene name synonym)|uniprotkb:PAR-6(gene name synonym)|uniprotkb:PAR6(gene name synonym)|uniprotkb:Par(gene name synonym)|uniprotkb:Par-6(gene name synonym)|uniprotkb:Par6(gene name synonym)|uniprotkb:dPAR-6(gene name synonym)|uniprotkb:dPar-6(gene name synonym)|uniprotkb:dmPar-6(gene name synonym)|uniprotkb:par(gene name synonym)|uniprotkb:par6(gene name synonym)|uniprotkb:Dmel_CG5884(orf name)|uniprotkb:CG5884(orf name)	psi-mi:"MI:0096"(pull down)	Wirtz-Peitz et al. (2008)	imex:IM-12136|pubmed:18854163	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2027376|imex:IM-12136-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	flybase:FBgn0021776|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005938"(cell cortex)|go:"GO:0007317"(regulation of pole plasm oskar mRNA localization)|go:"GO:0007400"(neuroblast fate determination)|go:"GO:0007402"(ganglion mother cell fate determination)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007419"(ventral cord development)|go:"GO:0008595"(anterior/posterior axis specification, embryo)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017022"(myosin binding)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0045178"(basal part of cell)|go:"GO:0045179"(apical cortex)|go:"GO:0045180"(basal cortex)|go:"GO:0048477"(oogenesis)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0072697"(protein localization to cell cortex)	refseq:NP_573238.1|flybase:FBgn0026192|refseq:NP_728094.1|dip:DIP-17759N|ensemblmetazoa:FBgn0026192(gene)|ensemblmetazoa:FBtr0074455(transcript)|ensemblmetazoa:FBtr0074456(transcript)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007416"(synapse assembly)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016332"(establishment or maintenance of polarity of embryonic epithelium)|go:"GO:0035003"(subapical complex)|go:"GO:0043195"(terminal bouton)|go:"GO:0045176"(apical protein localization)|go:"GO:0045179"(apical cortex)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0045196"(establishment or maintenance of neuroblast polarity)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045200"(establishment of neuroblast polarity)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0060341"(regulation of cellular localization)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0097482"(muscle cell postsynaptic specialization)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR034868|interpro:IPR034873|interpro:IPR036034|rcsb pdb:1RY4|rcsb pdb:1RZX|rcsb pdb:1X8S|rcsb pdb:2LC6|rcsb pdb:2LC7|rcsb pdb:5I7Z|reactome:R-DME-2173791|reactome:R-DME-4608870|reactome:R-DME-9013149	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 7A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/11/04	2014/10/16	rogid:BJlUYvSh2EVnA0PxNbeFipc/S207227	rogid:L8COGHmbjA0Br5eyBQPvEeCEQTw7227	intact-crc:0E8FA0A4134DC7C9|rigid:KNAfTI6UOYaVtG219Kb7qoa8UK4	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O44224	uniprotkb:O96782	intact:EBI-869852	intact:EBI-867941	psi-mi:o44224_drome(display_long)|uniprotkb:mira(gene name)|psi-mi:mira(display_short)|uniprotkb:CG12249(orf name)	psi-mi:o96782_drome(display_long)|uniprotkb:baz(gene name)|psi-mi:baz(display_short)|uniprotkb:bazooka(gene name synonym)|uniprotkb:CG5055(orf name)	psi-mi:"MI:0096"(pull down)	Wirtz-Peitz et al. (2008)	imex:IM-12136|pubmed:18854163	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2027376|imex:IM-12136-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	flybase:FBgn0021776|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005938"(cell cortex)|go:"GO:0007317"(regulation of pole plasm oskar mRNA localization)|go:"GO:0007400"(neuroblast fate determination)|go:"GO:0007402"(ganglion mother cell fate determination)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007419"(ventral cord development)|go:"GO:0008595"(anterior/posterior axis specification, embryo)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017022"(myosin binding)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0045178"(basal part of cell)|go:"GO:0045179"(apical cortex)|go:"GO:0045180"(basal cortex)|go:"GO:0048477"(oogenesis)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0072697"(protein localization to cell cortex)	flybase:FBgn0000163|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005912"(adherens junction)|go:"GO:0005914"(spot adherens junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0005938"(cell cortex)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007294"(germarium-derived oocyte fate determination)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007299"(ovarian follicle cell-cell adhesion)|go:"GO:0007314"(oocyte anterior/posterior axis specification)|go:"GO:0007377"(germ-band extension)|go:"GO:0007416"(synapse assembly)|go:"GO:0008104"(protein localization)|go:"GO:0008594"(photoreceptor cell morphogenesis)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016325"(oocyte microtubule cytoskeleton organization)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030709"(border follicle cell delamination)|go:"GO:0035089"(establishment of apical/basal cell polarity)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0051490"(negative regulation of filopodium assembly)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0072002"(Malpighian tubule development)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR021922|interpro:IPR036034|mint:O96782	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 7A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/11/04	2014/10/16	rogid:BJlUYvSh2EVnA0PxNbeFipc/S207227	rogid:UT2HtbwNRFuGCQL1dHzbkIBnJe47227	intact-crc:0E8FA0A4134DC7C9|rigid:KNAfTI6UOYaVtG219Kb7qoa8UK4	false	glutathione s tranferase tag:?-?	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O44224	uniprotkb:A1Z9X0	intact:EBI-869852	intact:EBI-160861|ensemblmetazoa:FBpp0292487|ensemblmetazoa:FBpp0292491|intact:EBI-2296820|intact:EBI-867915|intact:EBI-2027110|intact:EBI-2656028|uniprotkb:Q0E971|uniprotkb:Q0E972|uniprotkb:Q0E973|uniprotkb:Q0E974|uniprotkb:Q8MT38|uniprotkb:Q9GSZ3	psi-mi:o44224_drome(display_long)|uniprotkb:mira(gene name)|psi-mi:mira(display_short)|uniprotkb:CG12249(orf name)	psi-mi:apkc_drome(display_long)|uniprotkb:aPKC(gene name)|psi-mi:aPKC(display_short)|uniprotkb:CG30475(orf name)	psi-mi:"MI:0096"(pull down)	Wirtz-Peitz et al. (2008)	imex:IM-12136|pubmed:18854163	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2027376|imex:IM-12136-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	flybase:FBgn0021776|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005938"(cell cortex)|go:"GO:0007317"(regulation of pole plasm oskar mRNA localization)|go:"GO:0007400"(neuroblast fate determination)|go:"GO:0007402"(ganglion mother cell fate determination)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007419"(ventral cord development)|go:"GO:0008595"(anterior/posterior axis specification, embryo)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017022"(myosin binding)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0045178"(basal part of cell)|go:"GO:0045179"(apical cortex)|go:"GO:0045180"(basal cortex)|go:"GO:0048477"(oogenesis)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0072697"(protein localization to cell cortex)	refseq:NP_001036541.1|refseq:NP_524892.2|flybase:FBgn0261854|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0045176"(apical protein localization)|go:"GO:0045179"(apical cortex)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0045196"(establishment or maintenance of neuroblast polarity)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0046667"(compound eye retinal cell programmed cell death)|go:"GO:0046872"(metal ion binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051601"(exocyst localization)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090163"(establishment of epithelial cell planar polarity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140591"(nuclear envelope budding)|go:"GO:1904580"(regulation of intracellular mRNA localization)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012233(Protein kinase C, zeta/iota)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:0035331"(negative regulation of hippo signaling)|ensemblmetazoa:FBgn0261854(gene)|ensemblmetazoa:FBtr0303430(transcript)|ensemblmetazoa:FBtr0303434(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007294"(germarium-derived oocyte fate determination)|go:"GO:0007314"(oocyte anterior/posterior axis specification)|go:"GO:0007416"(synapse assembly)|go:"GO:0007423"(sensory organ development)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0007613"(memory)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016332"(establishment or maintenance of polarity of embryonic epithelium)|go:"GO:0016334"(establishment or maintenance of polarity of follicular epithelium)|go:"GO:0017022"(myosin binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030860"(regulation of polarized epithelial cell differentiation)|go:"GO:0034332"(adherens junction organization)|go:"GO:0035003"(subapical complex)|go:"GO:0035011"(melanotic encapsulation of foreign target)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034659|interpro:IPR034877|reactome:R-DME-2173791|reactome:R-DME-5218921|reactome:R-DME-9634635|refseq:NP_001036542.1|refseq:NP_001036543.1|refseq:NP_001036544.1|refseq:NP_001036545.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 7A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/11/04	2014/10/16	rogid:BJlUYvSh2EVnA0PxNbeFipc/S207227	rogid:w7Lc8l4/50NKAWamwS+Lzk6lbgA7227	intact-crc:0E8FA0A4134DC7C9|rigid:KNAfTI6UOYaVtG219Kb7qoa8UK4	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P16554	uniprotkb:O96782	intact:EBI-429581|uniprotkb:Q8IPE9|uniprotkb:Q961A6|uniprotkb:Q9VLB8|uniprotkb:B8A413|uniprotkb:B8A419|ensemblmetazoa:FBpp0079420|ensemblmetazoa:FBpp0308609	intact:EBI-867941	psi-mi:numb_drome(display_long)|uniprotkb:CG3779(orf name)|uniprotkb:numb(gene name)|psi-mi:numb(display_short)	psi-mi:o96782_drome(display_long)|uniprotkb:baz(gene name)|psi-mi:baz(display_short)|uniprotkb:bazooka(gene name synonym)|uniprotkb:CG5055(orf name)	psi-mi:"MI:0096"(pull down)	Wirtz-Peitz et al. (2008)	imex:IM-12136|pubmed:18854163	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2027390|imex:IM-12136-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_523523.2|refseq:NP_723460.1|flybase:FBgn0002973|refseq:NP_001260291.1|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051642"(centrosome localization)|go:"GO:0051960"(regulation of nervous system development)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0061320"(pericardial nephrocyte differentiation)|go:"GO:0061382"(Malpighian tubule tip cell differentiation)|go:"GO:1902692"(regulation of neuroblast proliferation)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR010449(NUMB phenylalanine-rich)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016698(Numb/numb-like)|mint:P16554|go:"GO:0045178"(basal part of cell)|rcsb pdb:1DDM|rcsb pdb:2NMB|rcsb pdb:5YI7|rcsb pdb:5YI8|reactome:R-DME-5610780|reactome:R-DME-5632684|ensemblmetazoa:FBgn0002973(gene)|ensemblmetazoa:FBtr0079822(transcript)|ensemblmetazoa:FBtr0339526(transcript)|go:"GO:0001920"(negative regulation of receptor recycling)|go:"GO:0005112"(Notch binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0008104"(protein localization)|go:"GO:0008347"(glial cell migration)|go:"GO:0009786"(regulation of asymmetric cell division)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014019"(neuroblast development)|go:"GO:0016360"(sensory organ precursor cell fate determination)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0042694"(muscle cell fate specification)|go:"GO:0045035"(sensory organ precursor cell division)	flybase:FBgn0000163|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005912"(adherens junction)|go:"GO:0005914"(spot adherens junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0005938"(cell cortex)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007294"(germarium-derived oocyte fate determination)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007299"(ovarian follicle cell-cell adhesion)|go:"GO:0007314"(oocyte anterior/posterior axis specification)|go:"GO:0007377"(germ-band extension)|go:"GO:0007416"(synapse assembly)|go:"GO:0008104"(protein localization)|go:"GO:0008594"(photoreceptor cell morphogenesis)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016325"(oocyte microtubule cytoskeleton organization)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030709"(border follicle cell delamination)|go:"GO:0035089"(establishment of apical/basal cell polarity)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0051490"(negative regulation of filopodium assembly)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0072002"(Malpighian tubule development)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR021922|interpro:IPR036034|mint:O96782	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 7A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/11/04	2014/10/16	rogid:9FGhbcAA6k1LCDHPoLSXwEEVwzY7227	rogid:UT2HtbwNRFuGCQL1dHzbkIBnJe47227	intact-crc:3261A4AD8C465323|rigid:W4cMIdUQj7CsFKkVrTebungkXoU	false	glutathione s tranferase tag:?-?	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P16554	uniprotkb:O97111	intact:EBI-429581|uniprotkb:Q8IPE9|uniprotkb:Q961A6|uniprotkb:Q9VLB8|uniprotkb:B8A413|uniprotkb:B8A419|ensemblmetazoa:FBpp0079420|ensemblmetazoa:FBpp0308609	intact:EBI-186645|ensemblmetazoa:FBpp0074229|ensemblmetazoa:FBpp0074230	psi-mi:numb_drome(display_long)|uniprotkb:CG3779(orf name)|uniprotkb:numb(gene name)|psi-mi:numb(display_short)	psi-mi:o97111_drome(display_long)|uniprotkb:par-6(gene name)|psi-mi:par-6(display_short)|uniprotkb:DPar-6(gene name synonym)|uniprotkb:DPar6(gene name synonym)|uniprotkb:Dm-Par-6(gene name synonym)|uniprotkb:Dm-Par6(gene name synonym)|uniprotkb:DmPAR-6(gene name synonym)|uniprotkb:DmPar-6(gene name synonym)|uniprotkb:DmPar6(gene name synonym)|uniprotkb:Dmel\CG5884(gene name synonym)|uniprotkb:Dmpar6(gene name synonym)|uniprotkb:PAR-6(gene name synonym)|uniprotkb:PAR6(gene name synonym)|uniprotkb:Par(gene name synonym)|uniprotkb:Par-6(gene name synonym)|uniprotkb:Par6(gene name synonym)|uniprotkb:dPAR-6(gene name synonym)|uniprotkb:dPar-6(gene name synonym)|uniprotkb:dmPar-6(gene name synonym)|uniprotkb:par(gene name synonym)|uniprotkb:par6(gene name synonym)|uniprotkb:Dmel_CG5884(orf name)|uniprotkb:CG5884(orf name)	psi-mi:"MI:0096"(pull down)	Wirtz-Peitz et al. (2008)	imex:IM-12136|pubmed:18854163	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2027390|imex:IM-12136-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_523523.2|refseq:NP_723460.1|flybase:FBgn0002973|refseq:NP_001260291.1|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051642"(centrosome localization)|go:"GO:0051960"(regulation of nervous system development)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0061320"(pericardial nephrocyte differentiation)|go:"GO:0061382"(Malpighian tubule tip cell differentiation)|go:"GO:1902692"(regulation of neuroblast proliferation)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR010449(NUMB phenylalanine-rich)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016698(Numb/numb-like)|mint:P16554|go:"GO:0045178"(basal part of cell)|rcsb pdb:1DDM|rcsb pdb:2NMB|rcsb pdb:5YI7|rcsb pdb:5YI8|reactome:R-DME-5610780|reactome:R-DME-5632684|ensemblmetazoa:FBgn0002973(gene)|ensemblmetazoa:FBtr0079822(transcript)|ensemblmetazoa:FBtr0339526(transcript)|go:"GO:0001920"(negative regulation of receptor recycling)|go:"GO:0005112"(Notch binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0008104"(protein localization)|go:"GO:0008347"(glial cell migration)|go:"GO:0009786"(regulation of asymmetric cell division)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014019"(neuroblast development)|go:"GO:0016360"(sensory organ precursor cell fate determination)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0042694"(muscle cell fate specification)|go:"GO:0045035"(sensory organ precursor cell division)	refseq:NP_573238.1|flybase:FBgn0026192|refseq:NP_728094.1|dip:DIP-17759N|ensemblmetazoa:FBgn0026192(gene)|ensemblmetazoa:FBtr0074455(transcript)|ensemblmetazoa:FBtr0074456(transcript)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007416"(synapse assembly)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016332"(establishment or maintenance of polarity of embryonic epithelium)|go:"GO:0035003"(subapical complex)|go:"GO:0043195"(terminal bouton)|go:"GO:0045176"(apical protein localization)|go:"GO:0045179"(apical cortex)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0045196"(establishment or maintenance of neuroblast polarity)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045200"(establishment of neuroblast polarity)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0060341"(regulation of cellular localization)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0097482"(muscle cell postsynaptic specialization)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR034868|interpro:IPR034873|interpro:IPR036034|rcsb pdb:1RY4|rcsb pdb:1RZX|rcsb pdb:1X8S|rcsb pdb:2LC6|rcsb pdb:2LC7|rcsb pdb:5I7Z|reactome:R-DME-2173791|reactome:R-DME-4608870|reactome:R-DME-9013149	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 7A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/11/04	2014/10/16	rogid:9FGhbcAA6k1LCDHPoLSXwEEVwzY7227	rogid:L8COGHmbjA0Br5eyBQPvEeCEQTw7227	intact-crc:3261A4AD8C465323|rigid:W4cMIdUQj7CsFKkVrTebungkXoU	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P16554	uniprotkb:A1Z9X0	intact:EBI-429581|uniprotkb:Q8IPE9|uniprotkb:Q961A6|uniprotkb:Q9VLB8|uniprotkb:B8A413|uniprotkb:B8A419|ensemblmetazoa:FBpp0079420|ensemblmetazoa:FBpp0308609	intact:EBI-160861|ensemblmetazoa:FBpp0292487|ensemblmetazoa:FBpp0292491|intact:EBI-2296820|intact:EBI-867915|intact:EBI-2027110|intact:EBI-2656028|uniprotkb:Q0E971|uniprotkb:Q0E972|uniprotkb:Q0E973|uniprotkb:Q0E974|uniprotkb:Q8MT38|uniprotkb:Q9GSZ3	psi-mi:numb_drome(display_long)|uniprotkb:CG3779(orf name)|uniprotkb:numb(gene name)|psi-mi:numb(display_short)	psi-mi:apkc_drome(display_long)|uniprotkb:aPKC(gene name)|psi-mi:aPKC(display_short)|uniprotkb:CG30475(orf name)	psi-mi:"MI:0096"(pull down)	Wirtz-Peitz et al. (2008)	imex:IM-12136|pubmed:18854163	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2027390|imex:IM-12136-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_523523.2|refseq:NP_723460.1|flybase:FBgn0002973|refseq:NP_001260291.1|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051642"(centrosome localization)|go:"GO:0051960"(regulation of nervous system development)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0061320"(pericardial nephrocyte differentiation)|go:"GO:0061382"(Malpighian tubule tip cell differentiation)|go:"GO:1902692"(regulation of neuroblast proliferation)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR010449(NUMB phenylalanine-rich)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016698(Numb/numb-like)|mint:P16554|go:"GO:0045178"(basal part of cell)|rcsb pdb:1DDM|rcsb pdb:2NMB|rcsb pdb:5YI7|rcsb pdb:5YI8|reactome:R-DME-5610780|reactome:R-DME-5632684|ensemblmetazoa:FBgn0002973(gene)|ensemblmetazoa:FBtr0079822(transcript)|ensemblmetazoa:FBtr0339526(transcript)|go:"GO:0001920"(negative regulation of receptor recycling)|go:"GO:0005112"(Notch binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0008104"(protein localization)|go:"GO:0008347"(glial cell migration)|go:"GO:0009786"(regulation of asymmetric cell division)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014019"(neuroblast development)|go:"GO:0016360"(sensory organ precursor cell fate determination)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0042694"(muscle cell fate specification)|go:"GO:0045035"(sensory organ precursor cell division)	refseq:NP_001036541.1|refseq:NP_524892.2|flybase:FBgn0261854|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0045176"(apical protein localization)|go:"GO:0045179"(apical cortex)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0045196"(establishment or maintenance of neuroblast polarity)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0046667"(compound eye retinal cell programmed cell death)|go:"GO:0046872"(metal ion binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051601"(exocyst localization)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090163"(establishment of epithelial cell planar polarity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140591"(nuclear envelope budding)|go:"GO:1904580"(regulation of intracellular mRNA localization)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012233(Protein kinase C, zeta/iota)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:0035331"(negative regulation of hippo signaling)|ensemblmetazoa:FBgn0261854(gene)|ensemblmetazoa:FBtr0303430(transcript)|ensemblmetazoa:FBtr0303434(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007294"(germarium-derived oocyte fate determination)|go:"GO:0007314"(oocyte anterior/posterior axis specification)|go:"GO:0007416"(synapse assembly)|go:"GO:0007423"(sensory organ development)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0007613"(memory)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016332"(establishment or maintenance of polarity of embryonic epithelium)|go:"GO:0016334"(establishment or maintenance of polarity of follicular epithelium)|go:"GO:0017022"(myosin binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030860"(regulation of polarized epithelial cell differentiation)|go:"GO:0034332"(adherens junction organization)|go:"GO:0035003"(subapical complex)|go:"GO:0035011"(melanotic encapsulation of foreign target)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034659|interpro:IPR034877|reactome:R-DME-2173791|reactome:R-DME-5218921|reactome:R-DME-9634635|refseq:NP_001036542.1|refseq:NP_001036543.1|refseq:NP_001036544.1|refseq:NP_001036545.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 7A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/11/04	2014/10/16	rogid:9FGhbcAA6k1LCDHPoLSXwEEVwzY7227	rogid:w7Lc8l4/50NKAWamwS+Lzk6lbgA7227	intact-crc:3261A4AD8C465323|rigid:W4cMIdUQj7CsFKkVrTebungkXoU	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P16554	uniprotkb:P91926	intact:EBI-429581|uniprotkb:Q8IPE9|uniprotkb:Q961A6|uniprotkb:Q9VLB8|uniprotkb:B8A413|uniprotkb:B8A419|ensemblmetazoa:FBpp0079420|ensemblmetazoa:FBpp0308609	intact:EBI-183420|uniprotkb:O01937|uniprotkb:Q7KTZ5|uniprotkb:Q86P64|uniprotkb:Q9VPP4|uniprotkb:B3DN51|ensemblmetazoa:FBpp0088490	psi-mi:numb_drome(display_long)|uniprotkb:CG3779(orf name)|uniprotkb:numb(gene name)|psi-mi:numb(display_short)	psi-mi:ap2a_drome(display_long)|uniprotkb:AP-2alpha(gene name)|psi-mi:AP-2alpha(display_short)|uniprotkb:Alpha-adaptin(gene name synonym)|uniprotkb:CG4260(orf name)	psi-mi:"MI:0096"(pull down)	Wirtz-Peitz et al. (2008)	imex:IM-12136|pubmed:18854163	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2027390|imex:IM-12136-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_523523.2|refseq:NP_723460.1|flybase:FBgn0002973|refseq:NP_001260291.1|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051642"(centrosome localization)|go:"GO:0051960"(regulation of nervous system development)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0061320"(pericardial nephrocyte differentiation)|go:"GO:0061382"(Malpighian tubule tip cell differentiation)|go:"GO:1902692"(regulation of neuroblast proliferation)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR010449(NUMB phenylalanine-rich)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016698(Numb/numb-like)|mint:P16554|go:"GO:0045178"(basal part of cell)|rcsb pdb:1DDM|rcsb pdb:2NMB|rcsb pdb:5YI7|rcsb pdb:5YI8|reactome:R-DME-5610780|reactome:R-DME-5632684|ensemblmetazoa:FBgn0002973(gene)|ensemblmetazoa:FBtr0079822(transcript)|ensemblmetazoa:FBtr0339526(transcript)|go:"GO:0001920"(negative regulation of receptor recycling)|go:"GO:0005112"(Notch binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0008104"(protein localization)|go:"GO:0008347"(glial cell migration)|go:"GO:0009786"(regulation of asymmetric cell division)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014019"(neuroblast development)|go:"GO:0016360"(sensory organ precursor cell fate determination)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0042694"(muscle cell fate specification)|go:"GO:0045035"(sensory organ precursor cell division)	refseq:NP_476819.2|refseq:NP_995607.1|flybase:FBgn0264855|ensemblmetazoa:FBgn0264855(gene)|ensemblmetazoa:FBtr0089488(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008104"(protein localization)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0015031"(protein transport)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0031623"(receptor internalization)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0038010"(positive regulation of signal transduction by receptor internalization)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098793"(presynapse)|go:"GO:0140312"(cargo adaptor activity)|go:"GO:1990386"(mitotic cleavage furrow ingression)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR003164(Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017104(Adaptor protein complex AP-2, alpha subunit)|reactome:R-DME-177504|reactome:R-DME-3928665|reactome:R-DME-437239|reactome:R-DME-5099900|reactome:R-DME-5140745|reactome:R-DME-6798695|reactome:R-DME-8856825|reactome:R-DME-8856828|reactome:R-DME-8866427|reactome:R-DME-8964038	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 7A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/11/04	2014/10/16	rogid:9FGhbcAA6k1LCDHPoLSXwEEVwzY7227	rogid:1kfuoodxtoNBOjXfMpYFk1SjWAA7227	intact-crc:3261A4AD8C465323|rigid:W4cMIdUQj7CsFKkVrTebungkXoU	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O97111	uniprotkb:A1Z9X0	intact:EBI-186645|ensemblmetazoa:FBpp0074229|ensemblmetazoa:FBpp0074230	intact:EBI-160861|ensemblmetazoa:FBpp0292487|ensemblmetazoa:FBpp0292491|intact:EBI-2296820|intact:EBI-867915|intact:EBI-2027110|intact:EBI-2656028|uniprotkb:Q0E971|uniprotkb:Q0E972|uniprotkb:Q0E973|uniprotkb:Q0E974|uniprotkb:Q8MT38|uniprotkb:Q9GSZ3	psi-mi:o97111_drome(display_long)|uniprotkb:par-6(gene name)|psi-mi:par-6(display_short)|uniprotkb:DPar-6(gene name synonym)|uniprotkb:DPar6(gene name synonym)|uniprotkb:Dm-Par-6(gene name synonym)|uniprotkb:Dm-Par6(gene name synonym)|uniprotkb:DmPAR-6(gene name synonym)|uniprotkb:DmPar-6(gene name synonym)|uniprotkb:DmPar6(gene name synonym)|uniprotkb:Dmel\CG5884(gene name synonym)|uniprotkb:Dmpar6(gene name synonym)|uniprotkb:PAR-6(gene name synonym)|uniprotkb:PAR6(gene name synonym)|uniprotkb:Par(gene name synonym)|uniprotkb:Par-6(gene name synonym)|uniprotkb:Par6(gene name synonym)|uniprotkb:dPAR-6(gene name synonym)|uniprotkb:dPar-6(gene name synonym)|uniprotkb:dmPar-6(gene name synonym)|uniprotkb:par(gene name synonym)|uniprotkb:par6(gene name synonym)|uniprotkb:Dmel_CG5884(orf name)|uniprotkb:CG5884(orf name)	psi-mi:apkc_drome(display_long)|uniprotkb:aPKC(gene name)|psi-mi:aPKC(display_short)|uniprotkb:CG30475(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wirtz-Peitz et al. (2008)	imex:IM-12136|pubmed:18854163	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2027165|imex:IM-12136-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_573238.1|flybase:FBgn0026192|refseq:NP_728094.1|dip:DIP-17759N|ensemblmetazoa:FBgn0026192(gene)|ensemblmetazoa:FBtr0074455(transcript)|ensemblmetazoa:FBtr0074456(transcript)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007416"(synapse assembly)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016332"(establishment or maintenance of polarity of embryonic epithelium)|go:"GO:0035003"(subapical complex)|go:"GO:0043195"(terminal bouton)|go:"GO:0045176"(apical protein localization)|go:"GO:0045179"(apical cortex)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0045196"(establishment or maintenance of neuroblast polarity)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045200"(establishment of neuroblast polarity)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0060341"(regulation of cellular localization)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0097482"(muscle cell postsynaptic specialization)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR034868|interpro:IPR034873|interpro:IPR036034|rcsb pdb:1RY4|rcsb pdb:1RZX|rcsb pdb:1X8S|rcsb pdb:2LC6|rcsb pdb:2LC7|rcsb pdb:5I7Z|reactome:R-DME-2173791|reactome:R-DME-4608870|reactome:R-DME-9013149	refseq:NP_001036541.1|refseq:NP_524892.2|flybase:FBgn0261854|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0045176"(apical protein localization)|go:"GO:0045179"(apical cortex)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0045196"(establishment or maintenance of neuroblast polarity)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0046667"(compound eye retinal cell programmed cell death)|go:"GO:0046872"(metal ion binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051601"(exocyst localization)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090163"(establishment of epithelial cell planar polarity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140591"(nuclear envelope budding)|go:"GO:1904580"(regulation of intracellular mRNA localization)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012233(Protein kinase C, zeta/iota)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:0035331"(negative regulation of hippo signaling)|ensemblmetazoa:FBgn0261854(gene)|ensemblmetazoa:FBtr0303430(transcript)|ensemblmetazoa:FBtr0303434(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007294"(germarium-derived oocyte fate determination)|go:"GO:0007314"(oocyte anterior/posterior axis specification)|go:"GO:0007416"(synapse assembly)|go:"GO:0007423"(sensory organ development)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0007613"(memory)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016332"(establishment or maintenance of polarity of embryonic epithelium)|go:"GO:0016334"(establishment or maintenance of polarity of follicular epithelium)|go:"GO:0017022"(myosin binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030860"(regulation of polarized epithelial cell differentiation)|go:"GO:0034332"(adherens junction organization)|go:"GO:0035003"(subapical complex)|go:"GO:0035011"(melanotic encapsulation of foreign target)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034659|interpro:IPR034877|reactome:R-DME-2173791|reactome:R-DME-5218921|reactome:R-DME-9634635|refseq:NP_001036542.1|refseq:NP_001036543.1|refseq:NP_001036544.1|refseq:NP_001036545.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4C|delivery method:O96782 transfection|comment:Par-6 immunoprecipitates from aurA mutants contained an excess of Lgl at the expense of Baz.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-larval_brain)|taxid:7227(Drosophila melanogaster larval brain)	-	2008/11/04	2014/10/16	rogid:L8COGHmbjA0Br5eyBQPvEeCEQTw7227	rogid:w7Lc8l4/50NKAWamwS+Lzk6lbgA7227	intact-crc:EC4A1465FB72AFE2|rigid:kuxWVAIsOyCUGOorUzjVpXYV7I8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O97111	uniprotkb:O96782	intact:EBI-186645|ensemblmetazoa:FBpp0074229|ensemblmetazoa:FBpp0074230	intact:EBI-867941	psi-mi:o97111_drome(display_long)|uniprotkb:par-6(gene name)|psi-mi:par-6(display_short)|uniprotkb:DPar-6(gene name synonym)|uniprotkb:DPar6(gene name synonym)|uniprotkb:Dm-Par-6(gene name synonym)|uniprotkb:Dm-Par6(gene name synonym)|uniprotkb:DmPAR-6(gene name synonym)|uniprotkb:DmPar-6(gene name synonym)|uniprotkb:DmPar6(gene name synonym)|uniprotkb:Dmel\CG5884(gene name synonym)|uniprotkb:Dmpar6(gene name synonym)|uniprotkb:PAR-6(gene name synonym)|uniprotkb:PAR6(gene name synonym)|uniprotkb:Par(gene name synonym)|uniprotkb:Par-6(gene name synonym)|uniprotkb:Par6(gene name synonym)|uniprotkb:dPAR-6(gene name synonym)|uniprotkb:dPar-6(gene name synonym)|uniprotkb:dmPar-6(gene name synonym)|uniprotkb:par(gene name synonym)|uniprotkb:par6(gene name synonym)|uniprotkb:Dmel_CG5884(orf name)|uniprotkb:CG5884(orf name)	psi-mi:o96782_drome(display_long)|uniprotkb:baz(gene name)|psi-mi:baz(display_short)|uniprotkb:bazooka(gene name synonym)|uniprotkb:CG5055(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wirtz-Peitz et al. (2008)	imex:IM-12136|pubmed:18854163	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2027165|imex:IM-12136-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_573238.1|flybase:FBgn0026192|refseq:NP_728094.1|dip:DIP-17759N|ensemblmetazoa:FBgn0026192(gene)|ensemblmetazoa:FBtr0074455(transcript)|ensemblmetazoa:FBtr0074456(transcript)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007416"(synapse assembly)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016332"(establishment or maintenance of polarity of embryonic epithelium)|go:"GO:0035003"(subapical complex)|go:"GO:0043195"(terminal bouton)|go:"GO:0045176"(apical protein localization)|go:"GO:0045179"(apical cortex)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0045196"(establishment or maintenance of neuroblast polarity)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045200"(establishment of neuroblast polarity)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0060341"(regulation of cellular localization)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0097482"(muscle cell postsynaptic specialization)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR034868|interpro:IPR034873|interpro:IPR036034|rcsb pdb:1RY4|rcsb pdb:1RZX|rcsb pdb:1X8S|rcsb pdb:2LC6|rcsb pdb:2LC7|rcsb pdb:5I7Z|reactome:R-DME-2173791|reactome:R-DME-4608870|reactome:R-DME-9013149	flybase:FBgn0000163|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005912"(adherens junction)|go:"GO:0005914"(spot adherens junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0005938"(cell cortex)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007294"(germarium-derived oocyte fate determination)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007299"(ovarian follicle cell-cell adhesion)|go:"GO:0007314"(oocyte anterior/posterior axis specification)|go:"GO:0007377"(germ-band extension)|go:"GO:0007416"(synapse assembly)|go:"GO:0008104"(protein localization)|go:"GO:0008594"(photoreceptor cell morphogenesis)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016325"(oocyte microtubule cytoskeleton organization)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030709"(border follicle cell delamination)|go:"GO:0035089"(establishment of apical/basal cell polarity)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0051490"(negative regulation of filopodium assembly)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0072002"(Malpighian tubule development)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR021922|interpro:IPR036034|mint:O96782	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4C|delivery method:O96782 transfection|comment:Par-6 immunoprecipitates from aurA mutants contained an excess of Lgl at the expense of Baz.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-larval_brain)|taxid:7227(Drosophila melanogaster larval brain)	-	2008/11/04	2014/10/16	rogid:L8COGHmbjA0Br5eyBQPvEeCEQTw7227	rogid:UT2HtbwNRFuGCQL1dHzbkIBnJe47227	intact-crc:EC4A1465FB72AFE2|rigid:kuxWVAIsOyCUGOorUzjVpXYV7I8	false	-	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O97111	uniprotkb:P08111	intact:EBI-186645|ensemblmetazoa:FBpp0074229|ensemblmetazoa:FBpp0074230	intact:EBI-497569|uniprotkb:Q0E8V5|uniprotkb:Q24377|uniprotkb:D0IQ91|uniprotkb:D0IQJ0|uniprotkb:Q8IPV4|uniprotkb:Q8IPV5|uniprotkb:Q9VPI1|uniprotkb:A4UZW0|ensemblmetazoa:FBpp0077828|ensemblmetazoa:FBpp0077829|ensemblmetazoa:FBpp0297544|ensemblmetazoa:FBpp0297545|ensemblmetazoa:FBpp0297546|ensemblmetazoa:FBpp0297547	psi-mi:o97111_drome(display_long)|uniprotkb:par-6(gene name)|psi-mi:par-6(display_short)|uniprotkb:DPar-6(gene name synonym)|uniprotkb:DPar6(gene name synonym)|uniprotkb:Dm-Par-6(gene name synonym)|uniprotkb:Dm-Par6(gene name synonym)|uniprotkb:DmPAR-6(gene name synonym)|uniprotkb:DmPar-6(gene name synonym)|uniprotkb:DmPar6(gene name synonym)|uniprotkb:Dmel\CG5884(gene name synonym)|uniprotkb:Dmpar6(gene name synonym)|uniprotkb:PAR-6(gene name synonym)|uniprotkb:PAR6(gene name synonym)|uniprotkb:Par(gene name synonym)|uniprotkb:Par-6(gene name synonym)|uniprotkb:Par6(gene name synonym)|uniprotkb:dPAR-6(gene name synonym)|uniprotkb:dPar-6(gene name synonym)|uniprotkb:dmPar-6(gene name synonym)|uniprotkb:par(gene name synonym)|uniprotkb:par6(gene name synonym)|uniprotkb:Dmel_CG5884(orf name)|uniprotkb:CG5884(orf name)	psi-mi:l2gl_drome(display_long)|uniprotkb:"l(2)gl"(gene name)|psi-mi:"l(2)gl"(display_short)|uniprotkb:CG2671(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wirtz-Peitz et al. (2008)	imex:IM-12136|pubmed:18854163	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2027165|imex:IM-12136-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_573238.1|flybase:FBgn0026192|refseq:NP_728094.1|dip:DIP-17759N|ensemblmetazoa:FBgn0026192(gene)|ensemblmetazoa:FBtr0074455(transcript)|ensemblmetazoa:FBtr0074456(transcript)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007416"(synapse assembly)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016332"(establishment or maintenance of polarity of embryonic epithelium)|go:"GO:0035003"(subapical complex)|go:"GO:0043195"(terminal bouton)|go:"GO:0045176"(apical protein localization)|go:"GO:0045179"(apical cortex)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0045196"(establishment or maintenance of neuroblast polarity)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045200"(establishment of neuroblast polarity)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0060341"(regulation of cellular localization)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0097482"(muscle cell postsynaptic specialization)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR034868|interpro:IPR034873|interpro:IPR036034|rcsb pdb:1RY4|rcsb pdb:1RZX|rcsb pdb:1X8S|rcsb pdb:2LC6|rcsb pdb:2LC7|rcsb pdb:5I7Z|reactome:R-DME-2173791|reactome:R-DME-4608870|reactome:R-DME-9013149	refseq:NP_523439.2|refseq:NP_722583.1|refseq:NP_722584.1|refseq:NP_722585.1|refseq:NP_722586.1|refseq:NP_722587.1|flybase:FBgn0002121|refseq:NP_001245801.1|refseq:NP_001245802.1|refseq:NP_001245803.1|refseq:NP_001245804.1|dip:DIP-22687N|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005920"(smooth septate junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006887"(exocytosis)|go:"GO:0007314"(oocyte anterior/posterior axis specification)|go:"GO:0007391"(dorsal closure)|go:"GO:0007399"(nervous system development)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007423"(sensory organ development)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0016325"(oocyte microtubule cytoskeleton organization)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016333"(morphogenesis of follicular epithelium)|go:"GO:0016334"(establishment or maintenance of polarity of follicular epithelium)|go:"GO:0016360"(sensory organ precursor cell fate determination)|go:"GO:0017022"(myosin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0019991"(septate junction assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031256"(leading edge membrane)|go:"GO:0032878"(regulation of establishment or maintenance of cell polarity)|go:"GO:0035070"(salivary gland histolysis)|go:"GO:0035072"(ecdysone-mediated induction of salivary gland cell autophagic cell death)|go:"GO:0035212"(cell competition in a multicellular organism)|go:"GO:0035293"(chitin-based larval cuticle pattern formation)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0045159"(myosin II binding)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0045175"(basal protein localization)|go:"GO:0045176"(apical protein localization)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045196"(establishment or maintenance of neuroblast polarity)|go:"GO:0045464"(R8 cell fate specification)|go:"GO:0045571"(negative regulation of imaginal disc growth)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048730"(epidermis morphogenesis)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0051294"(establishment of spindle orientation)|go:"GO:0051668"(localization within membrane)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0072697"(protein localization to cell cortex)|go:"GO:0090163"(establishment of epithelial cell planar polarity)|go:"GO:0098725"(symmetric cell division)|go:"GO:1904580"(regulation of intracellular mRNA localization)|interpro:IPR000664("Lethal(2) giant larvae protein")|interpro:IPR013577(Lethal giant larvae homologue 2)|interpro:IPR013905("Lethal giant larvae (Lgl) like, C-terminal")|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|ensemblmetazoa:FBgn0002121(gene)|ensemblmetazoa:FBtr0078170(transcript)|ensemblmetazoa:FBtr0078171(transcript)|ensemblmetazoa:FBtr0306589(transcript)|ensemblmetazoa:FBtr0306590(transcript)|ensemblmetazoa:FBtr0306591(transcript)|ensemblmetazoa:FBtr0306592(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0004860"(protein kinase inhibitor activity)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4C|delivery method:O96782 transfection|comment:Par-6 immunoprecipitates from aurA mutants contained an excess of Lgl at the expense of Baz.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-larval_brain)|taxid:7227(Drosophila melanogaster larval brain)	-	2008/11/04	2014/10/16	rogid:L8COGHmbjA0Br5eyBQPvEeCEQTw7227	rogid:wMEqgAEqWRfMWlyvB1PjKBJ/vuI7227	intact-crc:EC4A1465FB72AFE2|rigid:kuxWVAIsOyCUGOorUzjVpXYV7I8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O97111	uniprotkb:O96782	intact:EBI-186645|ensemblmetazoa:FBpp0074229|ensemblmetazoa:FBpp0074230	intact:EBI-867941	psi-mi:o97111_drome(display_long)|uniprotkb:par-6(gene name)|psi-mi:par-6(display_short)|uniprotkb:DPar-6(gene name synonym)|uniprotkb:DPar6(gene name synonym)|uniprotkb:Dm-Par-6(gene name synonym)|uniprotkb:Dm-Par6(gene name synonym)|uniprotkb:DmPAR-6(gene name synonym)|uniprotkb:DmPar-6(gene name synonym)|uniprotkb:DmPar6(gene name synonym)|uniprotkb:Dmel\CG5884(gene name synonym)|uniprotkb:Dmpar6(gene name synonym)|uniprotkb:PAR-6(gene name synonym)|uniprotkb:PAR6(gene name synonym)|uniprotkb:Par(gene name synonym)|uniprotkb:Par-6(gene name synonym)|uniprotkb:Par6(gene name synonym)|uniprotkb:dPAR-6(gene name synonym)|uniprotkb:dPar-6(gene name synonym)|uniprotkb:dmPar-6(gene name synonym)|uniprotkb:par(gene name synonym)|uniprotkb:par6(gene name synonym)|uniprotkb:Dmel_CG5884(orf name)|uniprotkb:CG5884(orf name)	psi-mi:o96782_drome(display_long)|uniprotkb:baz(gene name)|psi-mi:baz(display_short)|uniprotkb:bazooka(gene name synonym)|uniprotkb:CG5055(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wirtz-Peitz et al. (2008)	imex:IM-12136|pubmed:18854163	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2027176|imex:IM-12136-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_573238.1|flybase:FBgn0026192|refseq:NP_728094.1|dip:DIP-17759N|ensemblmetazoa:FBgn0026192(gene)|ensemblmetazoa:FBtr0074455(transcript)|ensemblmetazoa:FBtr0074456(transcript)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007416"(synapse assembly)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016332"(establishment or maintenance of polarity of embryonic epithelium)|go:"GO:0035003"(subapical complex)|go:"GO:0043195"(terminal bouton)|go:"GO:0045176"(apical protein localization)|go:"GO:0045179"(apical cortex)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0045196"(establishment or maintenance of neuroblast polarity)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045200"(establishment of neuroblast polarity)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0060341"(regulation of cellular localization)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0097482"(muscle cell postsynaptic specialization)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR034868|interpro:IPR034873|interpro:IPR036034|rcsb pdb:1RY4|rcsb pdb:1RZX|rcsb pdb:1X8S|rcsb pdb:2LC6|rcsb pdb:2LC7|rcsb pdb:5I7Z|reactome:R-DME-2173791|reactome:R-DME-4608870|reactome:R-DME-9013149	flybase:FBgn0000163|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005912"(adherens junction)|go:"GO:0005914"(spot adherens junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0005938"(cell cortex)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007294"(germarium-derived oocyte fate determination)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007299"(ovarian follicle cell-cell adhesion)|go:"GO:0007314"(oocyte anterior/posterior axis specification)|go:"GO:0007377"(germ-band extension)|go:"GO:0007416"(synapse assembly)|go:"GO:0008104"(protein localization)|go:"GO:0008594"(photoreceptor cell morphogenesis)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016325"(oocyte microtubule cytoskeleton organization)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030709"(border follicle cell delamination)|go:"GO:0035089"(establishment of apical/basal cell polarity)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0051490"(negative regulation of filopodium assembly)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0072002"(Malpighian tubule development)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR021922|interpro:IPR036034|mint:O96782	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4D|delivery method:P08111 ; O96782 transfection|comment:"Immunoprecipitates from l(2)gl3A  mutants contained an excess of Lgl at the expense of Baz."|caution:"Details of mutations to l(2)gl (P08111)taken from from PMID: 12629552 as referenced in the text."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-larval_brain)|taxid:7227(Drosophila melanogaster larval brain)	-	2008/11/04	2014/10/16	rogid:L8COGHmbjA0Br5eyBQPvEeCEQTw7227	rogid:UT2HtbwNRFuGCQL1dHzbkIBnJe47227	intact-crc:7150B63F3BBB4A24|rigid:kuxWVAIsOyCUGOorUzjVpXYV7I8	false	-	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O97111	uniprotkb:A1Z9X0	intact:EBI-186645|ensemblmetazoa:FBpp0074229|ensemblmetazoa:FBpp0074230	intact:EBI-160861|ensemblmetazoa:FBpp0292487|ensemblmetazoa:FBpp0292491|intact:EBI-2296820|intact:EBI-867915|intact:EBI-2027110|intact:EBI-2656028|uniprotkb:Q0E971|uniprotkb:Q0E972|uniprotkb:Q0E973|uniprotkb:Q0E974|uniprotkb:Q8MT38|uniprotkb:Q9GSZ3	psi-mi:o97111_drome(display_long)|uniprotkb:par-6(gene name)|psi-mi:par-6(display_short)|uniprotkb:DPar-6(gene name synonym)|uniprotkb:DPar6(gene name synonym)|uniprotkb:Dm-Par-6(gene name synonym)|uniprotkb:Dm-Par6(gene name synonym)|uniprotkb:DmPAR-6(gene name synonym)|uniprotkb:DmPar-6(gene name synonym)|uniprotkb:DmPar6(gene name synonym)|uniprotkb:Dmel\CG5884(gene name synonym)|uniprotkb:Dmpar6(gene name synonym)|uniprotkb:PAR-6(gene name synonym)|uniprotkb:PAR6(gene name synonym)|uniprotkb:Par(gene name synonym)|uniprotkb:Par-6(gene name synonym)|uniprotkb:Par6(gene name synonym)|uniprotkb:dPAR-6(gene name synonym)|uniprotkb:dPar-6(gene name synonym)|uniprotkb:dmPar-6(gene name synonym)|uniprotkb:par(gene name synonym)|uniprotkb:par6(gene name synonym)|uniprotkb:Dmel_CG5884(orf name)|uniprotkb:CG5884(orf name)	psi-mi:apkc_drome(display_long)|uniprotkb:aPKC(gene name)|psi-mi:aPKC(display_short)|uniprotkb:CG30475(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wirtz-Peitz et al. (2008)	imex:IM-12136|pubmed:18854163	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2027176|imex:IM-12136-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_573238.1|flybase:FBgn0026192|refseq:NP_728094.1|dip:DIP-17759N|ensemblmetazoa:FBgn0026192(gene)|ensemblmetazoa:FBtr0074455(transcript)|ensemblmetazoa:FBtr0074456(transcript)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007416"(synapse assembly)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016332"(establishment or maintenance of polarity of embryonic epithelium)|go:"GO:0035003"(subapical complex)|go:"GO:0043195"(terminal bouton)|go:"GO:0045176"(apical protein localization)|go:"GO:0045179"(apical cortex)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0045196"(establishment or maintenance of neuroblast polarity)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045200"(establishment of neuroblast polarity)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0060341"(regulation of cellular localization)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0097482"(muscle cell postsynaptic specialization)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR034868|interpro:IPR034873|interpro:IPR036034|rcsb pdb:1RY4|rcsb pdb:1RZX|rcsb pdb:1X8S|rcsb pdb:2LC6|rcsb pdb:2LC7|rcsb pdb:5I7Z|reactome:R-DME-2173791|reactome:R-DME-4608870|reactome:R-DME-9013149	refseq:NP_001036541.1|refseq:NP_524892.2|flybase:FBgn0261854|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0045176"(apical protein localization)|go:"GO:0045179"(apical cortex)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0045196"(establishment or maintenance of neuroblast polarity)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0046667"(compound eye retinal cell programmed cell death)|go:"GO:0046872"(metal ion binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051601"(exocyst localization)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090163"(establishment of epithelial cell planar polarity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140591"(nuclear envelope budding)|go:"GO:1904580"(regulation of intracellular mRNA localization)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012233(Protein kinase C, zeta/iota)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:0035331"(negative regulation of hippo signaling)|ensemblmetazoa:FBgn0261854(gene)|ensemblmetazoa:FBtr0303430(transcript)|ensemblmetazoa:FBtr0303434(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007294"(germarium-derived oocyte fate determination)|go:"GO:0007314"(oocyte anterior/posterior axis specification)|go:"GO:0007416"(synapse assembly)|go:"GO:0007423"(sensory organ development)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0007613"(memory)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016332"(establishment or maintenance of polarity of embryonic epithelium)|go:"GO:0016334"(establishment or maintenance of polarity of follicular epithelium)|go:"GO:0017022"(myosin binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030860"(regulation of polarized epithelial cell differentiation)|go:"GO:0034332"(adherens junction organization)|go:"GO:0035003"(subapical complex)|go:"GO:0035011"(melanotic encapsulation of foreign target)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034659|interpro:IPR034877|reactome:R-DME-2173791|reactome:R-DME-5218921|reactome:R-DME-9634635|refseq:NP_001036542.1|refseq:NP_001036543.1|refseq:NP_001036544.1|refseq:NP_001036545.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4D|delivery method:P08111 ; O96782 transfection|comment:"Immunoprecipitates from l(2)gl3A  mutants contained an excess of Lgl at the expense of Baz."|caution:"Details of mutations to l(2)gl (P08111)taken from from PMID: 12629552 as referenced in the text."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-larval_brain)|taxid:7227(Drosophila melanogaster larval brain)	-	2008/11/04	2014/10/16	rogid:L8COGHmbjA0Br5eyBQPvEeCEQTw7227	rogid:w7Lc8l4/50NKAWamwS+Lzk6lbgA7227	intact-crc:7150B63F3BBB4A24|rigid:kuxWVAIsOyCUGOorUzjVpXYV7I8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O97111	uniprotkb:P08111	intact:EBI-186645|ensemblmetazoa:FBpp0074229|ensemblmetazoa:FBpp0074230	intact:EBI-497569|uniprotkb:Q0E8V5|uniprotkb:Q24377|uniprotkb:D0IQ91|uniprotkb:D0IQJ0|uniprotkb:Q8IPV4|uniprotkb:Q8IPV5|uniprotkb:Q9VPI1|uniprotkb:A4UZW0|ensemblmetazoa:FBpp0077828|ensemblmetazoa:FBpp0077829|ensemblmetazoa:FBpp0297544|ensemblmetazoa:FBpp0297545|ensemblmetazoa:FBpp0297546|ensemblmetazoa:FBpp0297547	psi-mi:o97111_drome(display_long)|uniprotkb:par-6(gene name)|psi-mi:par-6(display_short)|uniprotkb:DPar-6(gene name synonym)|uniprotkb:DPar6(gene name synonym)|uniprotkb:Dm-Par-6(gene name synonym)|uniprotkb:Dm-Par6(gene name synonym)|uniprotkb:DmPAR-6(gene name synonym)|uniprotkb:DmPar-6(gene name synonym)|uniprotkb:DmPar6(gene name synonym)|uniprotkb:Dmel\CG5884(gene name synonym)|uniprotkb:Dmpar6(gene name synonym)|uniprotkb:PAR-6(gene name synonym)|uniprotkb:PAR6(gene name synonym)|uniprotkb:Par(gene name synonym)|uniprotkb:Par-6(gene name synonym)|uniprotkb:Par6(gene name synonym)|uniprotkb:dPAR-6(gene name synonym)|uniprotkb:dPar-6(gene name synonym)|uniprotkb:dmPar-6(gene name synonym)|uniprotkb:par(gene name synonym)|uniprotkb:par6(gene name synonym)|uniprotkb:Dmel_CG5884(orf name)|uniprotkb:CG5884(orf name)	psi-mi:l2gl_drome(display_long)|uniprotkb:"l(2)gl"(gene name)|psi-mi:"l(2)gl"(display_short)|uniprotkb:CG2671(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wirtz-Peitz et al. (2008)	imex:IM-12136|pubmed:18854163	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2027176|imex:IM-12136-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_573238.1|flybase:FBgn0026192|refseq:NP_728094.1|dip:DIP-17759N|ensemblmetazoa:FBgn0026192(gene)|ensemblmetazoa:FBtr0074455(transcript)|ensemblmetazoa:FBtr0074456(transcript)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007416"(synapse assembly)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016332"(establishment or maintenance of polarity of embryonic epithelium)|go:"GO:0035003"(subapical complex)|go:"GO:0043195"(terminal bouton)|go:"GO:0045176"(apical protein localization)|go:"GO:0045179"(apical cortex)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0045196"(establishment or maintenance of neuroblast polarity)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045200"(establishment of neuroblast polarity)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0060341"(regulation of cellular localization)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0097482"(muscle cell postsynaptic specialization)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR034868|interpro:IPR034873|interpro:IPR036034|rcsb pdb:1RY4|rcsb pdb:1RZX|rcsb pdb:1X8S|rcsb pdb:2LC6|rcsb pdb:2LC7|rcsb pdb:5I7Z|reactome:R-DME-2173791|reactome:R-DME-4608870|reactome:R-DME-9013149	refseq:NP_523439.2|refseq:NP_722583.1|refseq:NP_722584.1|refseq:NP_722585.1|refseq:NP_722586.1|refseq:NP_722587.1|flybase:FBgn0002121|refseq:NP_001245801.1|refseq:NP_001245802.1|refseq:NP_001245803.1|refseq:NP_001245804.1|dip:DIP-22687N|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005920"(smooth septate junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006887"(exocytosis)|go:"GO:0007314"(oocyte anterior/posterior axis specification)|go:"GO:0007391"(dorsal closure)|go:"GO:0007399"(nervous system development)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007423"(sensory organ development)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0016325"(oocyte microtubule cytoskeleton organization)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016333"(morphogenesis of follicular epithelium)|go:"GO:0016334"(establishment or maintenance of polarity of follicular epithelium)|go:"GO:0016360"(sensory organ precursor cell fate determination)|go:"GO:0017022"(myosin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0019991"(septate junction assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031256"(leading edge membrane)|go:"GO:0032878"(regulation of establishment or maintenance of cell polarity)|go:"GO:0035070"(salivary gland histolysis)|go:"GO:0035072"(ecdysone-mediated induction of salivary gland cell autophagic cell death)|go:"GO:0035212"(cell competition in a multicellular organism)|go:"GO:0035293"(chitin-based larval cuticle pattern formation)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0045159"(myosin II binding)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0045175"(basal protein localization)|go:"GO:0045176"(apical protein localization)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045196"(establishment or maintenance of neuroblast polarity)|go:"GO:0045464"(R8 cell fate specification)|go:"GO:0045571"(negative regulation of imaginal disc growth)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048730"(epidermis morphogenesis)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0051294"(establishment of spindle orientation)|go:"GO:0051668"(localization within membrane)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0072697"(protein localization to cell cortex)|go:"GO:0090163"(establishment of epithelial cell planar polarity)|go:"GO:0098725"(symmetric cell division)|go:"GO:1904580"(regulation of intracellular mRNA localization)|interpro:IPR000664("Lethal(2) giant larvae protein")|interpro:IPR013577(Lethal giant larvae homologue 2)|interpro:IPR013905("Lethal giant larvae (Lgl) like, C-terminal")|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|ensemblmetazoa:FBgn0002121(gene)|ensemblmetazoa:FBtr0078170(transcript)|ensemblmetazoa:FBtr0078171(transcript)|ensemblmetazoa:FBtr0306589(transcript)|ensemblmetazoa:FBtr0306590(transcript)|ensemblmetazoa:FBtr0306591(transcript)|ensemblmetazoa:FBtr0306592(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0004860"(protein kinase inhibitor activity)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4D|delivery method:P08111 ; O96782 transfection|comment:"Immunoprecipitates from l(2)gl3A  mutants contained an excess of Lgl at the expense of Baz."|caution:"Details of mutations to l(2)gl (P08111)taken from from PMID: 12629552 as referenced in the text."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-larval_brain)|taxid:7227(Drosophila melanogaster larval brain)	-	2008/11/04	2014/10/16	rogid:L8COGHmbjA0Br5eyBQPvEeCEQTw7227	rogid:wMEqgAEqWRfMWlyvB1PjKBJ/vuI7227	intact-crc:7150B63F3BBB4A24|rigid:kuxWVAIsOyCUGOorUzjVpXYV7I8	false	-	myc tag:?-?|mutation increasing interaction:656-656,664-664,660-660	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O96782	uniprotkb:A1Z9X0	intact:EBI-867941	intact:EBI-160861|ensemblmetazoa:FBpp0292487|ensemblmetazoa:FBpp0292491|intact:EBI-2296820|intact:EBI-867915|intact:EBI-2027110|intact:EBI-2656028|uniprotkb:Q0E971|uniprotkb:Q0E972|uniprotkb:Q0E973|uniprotkb:Q0E974|uniprotkb:Q8MT38|uniprotkb:Q9GSZ3	psi-mi:o96782_drome(display_long)|uniprotkb:baz(gene name)|psi-mi:baz(display_short)|uniprotkb:bazooka(gene name synonym)|uniprotkb:CG5055(orf name)	psi-mi:apkc_drome(display_long)|uniprotkb:aPKC(gene name)|psi-mi:aPKC(display_short)|uniprotkb:CG30475(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wirtz-Peitz et al. (2008)	imex:IM-12136|pubmed:18854163	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2027200|imex:IM-12136-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	flybase:FBgn0000163|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005912"(adherens junction)|go:"GO:0005914"(spot adherens junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0005938"(cell cortex)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007294"(germarium-derived oocyte fate determination)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007299"(ovarian follicle cell-cell adhesion)|go:"GO:0007314"(oocyte anterior/posterior axis specification)|go:"GO:0007377"(germ-band extension)|go:"GO:0007416"(synapse assembly)|go:"GO:0008104"(protein localization)|go:"GO:0008594"(photoreceptor cell morphogenesis)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016325"(oocyte microtubule cytoskeleton organization)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030709"(border follicle cell delamination)|go:"GO:0035089"(establishment of apical/basal cell polarity)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0051490"(negative regulation of filopodium assembly)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0072002"(Malpighian tubule development)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR021922|interpro:IPR036034|mint:O96782	refseq:NP_001036541.1|refseq:NP_524892.2|flybase:FBgn0261854|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0045176"(apical protein localization)|go:"GO:0045179"(apical cortex)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0045196"(establishment or maintenance of neuroblast polarity)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0046667"(compound eye retinal cell programmed cell death)|go:"GO:0046872"(metal ion binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051601"(exocyst localization)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090163"(establishment of epithelial cell planar polarity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140591"(nuclear envelope budding)|go:"GO:1904580"(regulation of intracellular mRNA localization)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012233(Protein kinase C, zeta/iota)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:0035331"(negative regulation of hippo signaling)|ensemblmetazoa:FBgn0261854(gene)|ensemblmetazoa:FBtr0303430(transcript)|ensemblmetazoa:FBtr0303434(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007294"(germarium-derived oocyte fate determination)|go:"GO:0007314"(oocyte anterior/posterior axis specification)|go:"GO:0007416"(synapse assembly)|go:"GO:0007423"(sensory organ development)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0007613"(memory)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016332"(establishment or maintenance of polarity of embryonic epithelium)|go:"GO:0016334"(establishment or maintenance of polarity of follicular epithelium)|go:"GO:0017022"(myosin binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030860"(regulation of polarized epithelial cell differentiation)|go:"GO:0034332"(adherens junction organization)|go:"GO:0035003"(subapical complex)|go:"GO:0035011"(melanotic encapsulation of foreign target)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034659|interpro:IPR034877|reactome:R-DME-2173791|reactome:R-DME-5218921|reactome:R-DME-9634635|refseq:NP_001036542.1|refseq:NP_001036543.1|refseq:NP_001036544.1|refseq:NP_001036545.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 6A|delivery method:O96782 transfection|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-embryo)|taxid:7227(drosophilla melanogaster embryo)	-	2008/11/04	2014/10/16	rogid:UT2HtbwNRFuGCQL1dHzbkIBnJe47227	rogid:w7Lc8l4/50NKAWamwS+Lzk6lbgA7227	intact-crc:221036C9C457E3E6|rigid:dltBqySbbhpcY2BX4OnW8o29/6s	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:A1Z9X0	uniprotkb:P08111	intact:EBI-160861|ensemblmetazoa:FBpp0292487|ensemblmetazoa:FBpp0292491|intact:EBI-2296820|intact:EBI-867915|intact:EBI-2027110|intact:EBI-2656028|uniprotkb:Q0E971|uniprotkb:Q0E972|uniprotkb:Q0E973|uniprotkb:Q0E974|uniprotkb:Q8MT38|uniprotkb:Q9GSZ3	intact:EBI-497569|uniprotkb:Q0E8V5|uniprotkb:Q24377|uniprotkb:D0IQ91|uniprotkb:D0IQJ0|uniprotkb:Q8IPV4|uniprotkb:Q8IPV5|uniprotkb:Q9VPI1|uniprotkb:A4UZW0|ensemblmetazoa:FBpp0077828|ensemblmetazoa:FBpp0077829|ensemblmetazoa:FBpp0297544|ensemblmetazoa:FBpp0297545|ensemblmetazoa:FBpp0297546|ensemblmetazoa:FBpp0297547	psi-mi:apkc_drome(display_long)|uniprotkb:aPKC(gene name)|psi-mi:aPKC(display_short)|uniprotkb:CG30475(orf name)	psi-mi:l2gl_drome(display_long)|uniprotkb:"l(2)gl"(gene name)|psi-mi:"l(2)gl"(display_short)|uniprotkb:CG2671(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wirtz-Peitz et al. (2008)	imex:IM-12136|pubmed:18854163	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2027216|imex:IM-12136-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001036541.1|refseq:NP_524892.2|flybase:FBgn0261854|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0045176"(apical protein localization)|go:"GO:0045179"(apical cortex)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0045196"(establishment or maintenance of neuroblast polarity)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0046667"(compound eye retinal cell programmed cell death)|go:"GO:0046872"(metal ion binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051601"(exocyst localization)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090163"(establishment of epithelial cell planar polarity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140591"(nuclear envelope budding)|go:"GO:1904580"(regulation of intracellular mRNA localization)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012233(Protein kinase C, zeta/iota)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:0035331"(negative regulation of hippo signaling)|ensemblmetazoa:FBgn0261854(gene)|ensemblmetazoa:FBtr0303430(transcript)|ensemblmetazoa:FBtr0303434(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007294"(germarium-derived oocyte fate determination)|go:"GO:0007314"(oocyte anterior/posterior axis specification)|go:"GO:0007416"(synapse assembly)|go:"GO:0007423"(sensory organ development)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0007613"(memory)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016332"(establishment or maintenance of polarity of embryonic epithelium)|go:"GO:0016334"(establishment or maintenance of polarity of follicular epithelium)|go:"GO:0017022"(myosin binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030860"(regulation of polarized epithelial cell differentiation)|go:"GO:0034332"(adherens junction organization)|go:"GO:0035003"(subapical complex)|go:"GO:0035011"(melanotic encapsulation of foreign target)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034659|interpro:IPR034877|reactome:R-DME-2173791|reactome:R-DME-5218921|reactome:R-DME-9634635|refseq:NP_001036542.1|refseq:NP_001036543.1|refseq:NP_001036544.1|refseq:NP_001036545.1	refseq:NP_523439.2|refseq:NP_722583.1|refseq:NP_722584.1|refseq:NP_722585.1|refseq:NP_722586.1|refseq:NP_722587.1|flybase:FBgn0002121|refseq:NP_001245801.1|refseq:NP_001245802.1|refseq:NP_001245803.1|refseq:NP_001245804.1|dip:DIP-22687N|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005920"(smooth septate junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006887"(exocytosis)|go:"GO:0007314"(oocyte anterior/posterior axis specification)|go:"GO:0007391"(dorsal closure)|go:"GO:0007399"(nervous system development)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007423"(sensory organ development)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0016325"(oocyte microtubule cytoskeleton organization)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016333"(morphogenesis of follicular epithelium)|go:"GO:0016334"(establishment or maintenance of polarity of follicular epithelium)|go:"GO:0016360"(sensory organ precursor cell fate determination)|go:"GO:0017022"(myosin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0019991"(septate junction assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031256"(leading edge membrane)|go:"GO:0032878"(regulation of establishment or maintenance of cell polarity)|go:"GO:0035070"(salivary gland histolysis)|go:"GO:0035072"(ecdysone-mediated induction of salivary gland cell autophagic cell death)|go:"GO:0035212"(cell competition in a multicellular organism)|go:"GO:0035293"(chitin-based larval cuticle pattern formation)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0045159"(myosin II binding)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0045175"(basal protein localization)|go:"GO:0045176"(apical protein localization)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045196"(establishment or maintenance of neuroblast polarity)|go:"GO:0045464"(R8 cell fate specification)|go:"GO:0045571"(negative regulation of imaginal disc growth)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048730"(epidermis morphogenesis)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0051294"(establishment of spindle orientation)|go:"GO:0051668"(localization within membrane)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0072697"(protein localization to cell cortex)|go:"GO:0090163"(establishment of epithelial cell planar polarity)|go:"GO:0098725"(symmetric cell division)|go:"GO:1904580"(regulation of intracellular mRNA localization)|interpro:IPR000664("Lethal(2) giant larvae protein")|interpro:IPR013577(Lethal giant larvae homologue 2)|interpro:IPR013905("Lethal giant larvae (Lgl) like, C-terminal")|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|ensemblmetazoa:FBgn0002121(gene)|ensemblmetazoa:FBtr0078170(transcript)|ensemblmetazoa:FBtr0078171(transcript)|ensemblmetazoa:FBtr0306589(transcript)|ensemblmetazoa:FBtr0306590(transcript)|ensemblmetazoa:FBtr0306591(transcript)|ensemblmetazoa:FBtr0306592(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0004860"(protein kinase inhibitor activity)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 6A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-embryo)|taxid:7227(drosophilla melanogaster embryo)	-	2008/11/04	2014/10/16	rogid:w7Lc8l4/50NKAWamwS+Lzk6lbgA7227	rogid:wMEqgAEqWRfMWlyvB1PjKBJ/vuI7227	intact-crc:422EFE3E05DF6FE5|rigid:VOXI4Uy+0shvU5x4kMRR5mQiOUQ	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:A1Z9X0	uniprotkb:P16554	intact:EBI-160861|ensemblmetazoa:FBpp0292487|ensemblmetazoa:FBpp0292491|intact:EBI-2296820|intact:EBI-867915|intact:EBI-2027110|intact:EBI-2656028|uniprotkb:Q0E971|uniprotkb:Q0E972|uniprotkb:Q0E973|uniprotkb:Q0E974|uniprotkb:Q8MT38|uniprotkb:Q9GSZ3	intact:EBI-429581|uniprotkb:Q8IPE9|uniprotkb:Q961A6|uniprotkb:Q9VLB8|uniprotkb:B8A413|uniprotkb:B8A419|ensemblmetazoa:FBpp0079420|ensemblmetazoa:FBpp0308609	psi-mi:apkc_drome(display_long)|uniprotkb:aPKC(gene name)|psi-mi:aPKC(display_short)|uniprotkb:CG30475(orf name)	psi-mi:numb_drome(display_long)|uniprotkb:CG3779(orf name)|uniprotkb:numb(gene name)|psi-mi:numb(display_short)	psi-mi:"MI:0424"(protein kinase assay)	Wirtz-Peitz et al. (2008)	imex:IM-12136|pubmed:18854163	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2027230|imex:IM-12136-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001036541.1|refseq:NP_524892.2|flybase:FBgn0261854|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0045176"(apical protein localization)|go:"GO:0045179"(apical cortex)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0045196"(establishment or maintenance of neuroblast polarity)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0046667"(compound eye retinal cell programmed cell death)|go:"GO:0046872"(metal ion binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051601"(exocyst localization)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090163"(establishment of epithelial cell planar polarity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140591"(nuclear envelope budding)|go:"GO:1904580"(regulation of intracellular mRNA localization)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012233(Protein kinase C, zeta/iota)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:0035331"(negative regulation of hippo signaling)|ensemblmetazoa:FBgn0261854(gene)|ensemblmetazoa:FBtr0303430(transcript)|ensemblmetazoa:FBtr0303434(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007294"(germarium-derived oocyte fate determination)|go:"GO:0007314"(oocyte anterior/posterior axis specification)|go:"GO:0007416"(synapse assembly)|go:"GO:0007423"(sensory organ development)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0007613"(memory)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016332"(establishment or maintenance of polarity of embryonic epithelium)|go:"GO:0016334"(establishment or maintenance of polarity of follicular epithelium)|go:"GO:0017022"(myosin binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030860"(regulation of polarized epithelial cell differentiation)|go:"GO:0034332"(adherens junction organization)|go:"GO:0035003"(subapical complex)|go:"GO:0035011"(melanotic encapsulation of foreign target)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034659|interpro:IPR034877|reactome:R-DME-2173791|reactome:R-DME-5218921|reactome:R-DME-9634635|refseq:NP_001036542.1|refseq:NP_001036543.1|refseq:NP_001036544.1|refseq:NP_001036545.1	refseq:NP_523523.2|refseq:NP_723460.1|flybase:FBgn0002973|refseq:NP_001260291.1|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051642"(centrosome localization)|go:"GO:0051960"(regulation of nervous system development)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0061320"(pericardial nephrocyte differentiation)|go:"GO:0061382"(Malpighian tubule tip cell differentiation)|go:"GO:1902692"(regulation of neuroblast proliferation)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR010449(NUMB phenylalanine-rich)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016698(Numb/numb-like)|mint:P16554|go:"GO:0045178"(basal part of cell)|rcsb pdb:1DDM|rcsb pdb:2NMB|rcsb pdb:5YI7|rcsb pdb:5YI8|reactome:R-DME-5610780|reactome:R-DME-5632684|ensemblmetazoa:FBgn0002973(gene)|ensemblmetazoa:FBtr0079822(transcript)|ensemblmetazoa:FBtr0339526(transcript)|go:"GO:0001920"(negative regulation of receptor recycling)|go:"GO:0005112"(Notch binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0008104"(protein localization)|go:"GO:0008347"(glial cell migration)|go:"GO:0009786"(regulation of asymmetric cell division)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014019"(neuroblast development)|go:"GO:0016360"(sensory organ precursor cell fate determination)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0042694"(muscle cell fate specification)|go:"GO:0045035"(sensory organ precursor cell division)	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:Fig. 6A|resulting-ptm:Phosphorylation of Numb|inhibition:"A pseudo-substrate inhibitor of aPKC (SIYRRGARRWRKL)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/11/04	2014/10/16	rogid:w7Lc8l4/50NKAWamwS+Lzk6lbgA7227	rogid:9FGhbcAA6k1LCDHPoLSXwEEVwzY7227	intact-crc:5FD87CCD5125D3FD|rigid:medJ1FPhbGAhF6mSD0pnc0lZTho	false	-	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:A1Z9X0	uniprotkb:O96782	intact:EBI-160861|ensemblmetazoa:FBpp0292487|ensemblmetazoa:FBpp0292491|intact:EBI-2296820|intact:EBI-867915|intact:EBI-2027110|intact:EBI-2656028|uniprotkb:Q0E971|uniprotkb:Q0E972|uniprotkb:Q0E973|uniprotkb:Q0E974|uniprotkb:Q8MT38|uniprotkb:Q9GSZ3	intact:EBI-867941	psi-mi:apkc_drome(display_long)|uniprotkb:aPKC(gene name)|psi-mi:aPKC(display_short)|uniprotkb:CG30475(orf name)	psi-mi:o96782_drome(display_long)|uniprotkb:baz(gene name)|psi-mi:baz(display_short)|uniprotkb:bazooka(gene name synonym)|uniprotkb:CG5055(orf name)	psi-mi:"MI:0424"(protein kinase assay)	Wirtz-Peitz et al. (2008)	imex:IM-12136|pubmed:18854163	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2027230|imex:IM-12136-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001036541.1|refseq:NP_524892.2|flybase:FBgn0261854|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0045176"(apical protein localization)|go:"GO:0045179"(apical cortex)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0045196"(establishment or maintenance of neuroblast polarity)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0046667"(compound eye retinal cell programmed cell death)|go:"GO:0046872"(metal ion binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051601"(exocyst localization)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090163"(establishment of epithelial cell planar polarity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140591"(nuclear envelope budding)|go:"GO:1904580"(regulation of intracellular mRNA localization)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012233(Protein kinase C, zeta/iota)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:0035331"(negative regulation of hippo signaling)|ensemblmetazoa:FBgn0261854(gene)|ensemblmetazoa:FBtr0303430(transcript)|ensemblmetazoa:FBtr0303434(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007294"(germarium-derived oocyte fate determination)|go:"GO:0007314"(oocyte anterior/posterior axis specification)|go:"GO:0007416"(synapse assembly)|go:"GO:0007423"(sensory organ development)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0007613"(memory)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016332"(establishment or maintenance of polarity of embryonic epithelium)|go:"GO:0016334"(establishment or maintenance of polarity of follicular epithelium)|go:"GO:0017022"(myosin binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030860"(regulation of polarized epithelial cell differentiation)|go:"GO:0034332"(adherens junction organization)|go:"GO:0035003"(subapical complex)|go:"GO:0035011"(melanotic encapsulation of foreign target)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034659|interpro:IPR034877|reactome:R-DME-2173791|reactome:R-DME-5218921|reactome:R-DME-9634635|refseq:NP_001036542.1|refseq:NP_001036543.1|refseq:NP_001036544.1|refseq:NP_001036545.1	flybase:FBgn0000163|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005912"(adherens junction)|go:"GO:0005914"(spot adherens junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0005938"(cell cortex)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007294"(germarium-derived oocyte fate determination)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007299"(ovarian follicle cell-cell adhesion)|go:"GO:0007314"(oocyte anterior/posterior axis specification)|go:"GO:0007377"(germ-band extension)|go:"GO:0007416"(synapse assembly)|go:"GO:0008104"(protein localization)|go:"GO:0008594"(photoreceptor cell morphogenesis)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016325"(oocyte microtubule cytoskeleton organization)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030709"(border follicle cell delamination)|go:"GO:0035089"(establishment of apical/basal cell polarity)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0051490"(negative regulation of filopodium assembly)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0072002"(Malpighian tubule development)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR021922|interpro:IPR036034|mint:O96782	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:Fig. 6A|resulting-ptm:Phosphorylation of Numb|inhibition:"A pseudo-substrate inhibitor of aPKC (SIYRRGARRWRKL)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/11/04	2014/10/16	rogid:w7Lc8l4/50NKAWamwS+Lzk6lbgA7227	rogid:UT2HtbwNRFuGCQL1dHzbkIBnJe47227	intact-crc:5FD87CCD5125D3FD|rigid:medJ1FPhbGAhF6mSD0pnc0lZTho	false	-	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)