#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8VI56	uniprotkb:P25304	intact:EBI-2106160|uniprotkb:Q8BPX5|uniprotkb:Q8CBB3|uniprotkb:Q8CCP5|uniprotkb:A2AGT4|ensembl:ENSMUSP00000028689	intact:EBI-2106099|uniprotkb:Q63034	psi-mi:lrp4_mouse(display_long)|uniprotkb:Lrp4(gene name)|psi-mi:Lrp4(display_short)|uniprotkb:Kiaa0816(gene name synonym)|uniprotkb:LDLR dan(gene name synonym)	psi-mi:agrin_rat(display_long)|uniprotkb:Agrn(gene name)|psi-mi:Agrn(display_short)|uniprotkb:Agrin(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kim et al. (2008)	imex:IM-12138|pubmed:18848351	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2106143|imex:IM-12138-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139329.1|refseq:NP_766256.3|ensembl:ENSMUSG00000027253(gene)|ensembl:ENSMUST00000028689(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0008104"(protein localization)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0009986"(cell surface)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030425"(dendrite)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0051124"(synaptic assembly at neuromuscular junction)|go:"GO:0060173"(limb development)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1901631"(positive regulation of presynaptic membrane organization)|go:"GO:1904395"(positive regulation of skeletal muscle acetylcholine-gated channel clustering)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|interpro:IPR026823|interpro:IPR036055|mint:Q8VI56	rgd:2067|refseq:NP_786930.1|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR001791(Laminin G)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR000082(SEA)|rcsb pdb:3V64|rcsb pdb:3V65|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003884(Factor I membrane attack complex)|interpro:IPR036058|interpro:IPR036364|reactome:R-RNO-1971475|reactome:R-RNO-2022928|reactome:R-RNO-2024096|reactome:R-RNO-3000178|reactome:R-RNO-975634|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002162"(dystroglycan binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0033691"(sialic acid binding)|go:"GO:0035374"(chondroitin sulfate binding)|go:"GO:0036122"(BMP binding)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042383"(sarcolemma)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:0045213"(neurotransmitter receptor metabolic process)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902667"(regulation of axon guidance)|go:"GO:1903277"(negative regulation of sodium ion export across plasma membrane)|go:"GO:1903407"("negative regulation of P-type sodium:potassium-exchanging transporter activity")|go:"GO:2000541"(positive regulation of protein geranylgeranylation)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2|caution:The information supplied did not allow the unambiguous assignment of this protein to a single UniProt isoform.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/11/11	2014/10/16	rogid:ZKhXi4AMVjK5LFe+xQHieJ2bomY10090	rogid:FVRnqwtFsDQkLUft9sT/oazcZZM10116	intact-crc:5DA969ED41002BA3|rigid:P2O//PY592eY4Q5ek3MJ/4DIlq0	false	flag tag:n-n|red fluorescent protein tag:c-c	sufficient binding region:c-c|his tag:n-n|myc tag:n-n|ha tag:c-c	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P25304	uniprotkb:Q8VI56	intact:EBI-2106099|uniprotkb:Q63034	intact:EBI-2106160|uniprotkb:Q8BPX5|uniprotkb:Q8CBB3|uniprotkb:Q8CCP5|uniprotkb:A2AGT4|ensembl:ENSMUSP00000028689	psi-mi:agrin_rat(display_long)|uniprotkb:Agrn(gene name)|psi-mi:Agrn(display_short)|uniprotkb:Agrin(gene name synonym)	psi-mi:lrp4_mouse(display_long)|uniprotkb:Lrp4(gene name)|psi-mi:Lrp4(display_short)|uniprotkb:Kiaa0816(gene name synonym)|uniprotkb:LDLR dan(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kim et al. (2008)	imex:IM-12138|pubmed:18848351	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2106231|imex:IM-12138-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2067|refseq:NP_786930.1|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR001791(Laminin G)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR000082(SEA)|rcsb pdb:3V64|rcsb pdb:3V65|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003884(Factor I membrane attack complex)|interpro:IPR036058|interpro:IPR036364|reactome:R-RNO-1971475|reactome:R-RNO-2022928|reactome:R-RNO-2024096|reactome:R-RNO-3000178|reactome:R-RNO-975634|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002162"(dystroglycan binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0033691"(sialic acid binding)|go:"GO:0035374"(chondroitin sulfate binding)|go:"GO:0036122"(BMP binding)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042383"(sarcolemma)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:0045213"(neurotransmitter receptor metabolic process)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902667"(regulation of axon guidance)|go:"GO:1903277"(negative regulation of sodium ion export across plasma membrane)|go:"GO:1903407"("negative regulation of P-type sodium:potassium-exchanging transporter activity")|go:"GO:2000541"(positive regulation of protein geranylgeranylation)	refseq:NP_001139329.1|refseq:NP_766256.3|ensembl:ENSMUSG00000027253(gene)|ensembl:ENSMUST00000028689(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0008104"(protein localization)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0009986"(cell surface)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030425"(dendrite)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0051124"(synaptic assembly at neuromuscular junction)|go:"GO:0060173"(limb development)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1901631"(positive regulation of presynaptic membrane organization)|go:"GO:1904395"(positive regulation of skeletal muscle acetylcholine-gated channel clustering)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|interpro:IPR026823|interpro:IPR036055|mint:Q8VI56	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3|kinetics:Half maximal binding at 6 nM Agrin|agonist:Calcium, increase binding by 20-fold|caution:Agrin construct was agrin B8 - a neuronal isoform containing a C-terminal amino acid insert. This could not be unambiguously mapped to the existing UniProt isoforms. It is unclear how the Cy5 label is bound and which of the tags present on the original construct are present after this process.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/11/11	2014/10/16	rogid:FVRnqwtFsDQkLUft9sT/oazcZZM10116	rogid:ZKhXi4AMVjK5LFe+xQHieJ2bomY10090	intact-crc:651FDEB66B076655|rigid:P2O//PY592eY4Q5ek3MJ/4DIlq0	false	myc tag:n-n|ha tag:c-c|sufficient binding region:c-c|his tag:n-n|cy5 label:?-?	flag tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P25304	uniprotkb:Q62838	intact:EBI-2106099|uniprotkb:Q63034	intact:EBI-2106354	psi-mi:agrin_rat(display_long)|uniprotkb:Agrn(gene name)|psi-mi:Agrn(display_short)|uniprotkb:Agrin(gene name synonym)	psi-mi:musk_rat(display_long)|uniprotkb:Musk(gene name)|psi-mi:Musk(display_short)|uniprotkb:Muscle-specific tyrosine protein kinase receptor(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kim et al. (2008)	imex:IM-12138|pubmed:18848351	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2106375|imex:IM-12138-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2067|refseq:NP_786930.1|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR001791(Laminin G)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR000082(SEA)|rcsb pdb:3V64|rcsb pdb:3V65|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003884(Factor I membrane attack complex)|interpro:IPR036058|interpro:IPR036364|reactome:R-RNO-1971475|reactome:R-RNO-2022928|reactome:R-RNO-2024096|reactome:R-RNO-3000178|reactome:R-RNO-975634|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002162"(dystroglycan binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0033691"(sialic acid binding)|go:"GO:0035374"(chondroitin sulfate binding)|go:"GO:0036122"(BMP binding)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042383"(sarcolemma)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:0045213"(neurotransmitter receptor metabolic process)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902667"(regulation of axon guidance)|go:"GO:1903277"(negative regulation of sodium ion export across plasma membrane)|go:"GO:1903407"("negative regulation of P-type sodium:potassium-exchanging transporter activity")|go:"GO:2000541"(positive regulation of protein geranylgeranylation)	rgd:3211|refseq:NP_112323.1|interpro:IPR020067|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR020635|rcsb pdb:1LUF|rcsb pdb:2IEP|rcsb pdb:3HKL|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR036179|interpro:IPR036790|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0007613"(memory)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014850"(response to muscle activity)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032224"(positive regulation of synaptic transmission, cholinergic)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0038062"(protein tyrosine kinase collagen receptor activity)|go:"GO:0042995"(cell projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043235"(receptor complex)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0090102"(cochlea development)|go:"GO:1904395"(positive regulation of skeletal muscle acetylcholine-gated channel clustering)|go:"GO:2000541"(positive regulation of protein geranylgeranylation)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3D|caution:Agrin construct was agrin B8 - a neuronal isoform containing a C-terminal amino acid insert. This could not be unambiguously mapped to the existing UniProt isoforms. It is unclear how the Cy5 label is bound and which of the tags present on the original construct are present after this process.|comment:Cells expressing both Lrp4 and Musk bound Agrin more effectively than cells expressing Lrp4 alone.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/11/11	2014/10/16	rogid:FVRnqwtFsDQkLUft9sT/oazcZZM10116	rogid:NV3O9XtmNH+jheY8vIiWBVHed8s10116	intact-crc:E6EFA042B7E014A7|rigid:fYfmwc6jixiq0+bB6IXDrL+qGus	false	ha tag:?-?|sufficient binding region:c-c|his tag:n-n|cy5 label:?-?|myc tag:n-n	green fluorescent protein tag:c-c|myc tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P25304	uniprotkb:Q8VI56	intact:EBI-2106099|uniprotkb:Q63034	intact:EBI-2106160|uniprotkb:Q8BPX5|uniprotkb:Q8CBB3|uniprotkb:Q8CCP5|uniprotkb:A2AGT4|ensembl:ENSMUSP00000028689	psi-mi:agrin_rat(display_long)|uniprotkb:Agrn(gene name)|psi-mi:Agrn(display_short)|uniprotkb:Agrin(gene name synonym)	psi-mi:lrp4_mouse(display_long)|uniprotkb:Lrp4(gene name)|psi-mi:Lrp4(display_short)|uniprotkb:Kiaa0816(gene name synonym)|uniprotkb:LDLR dan(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kim et al. (2008)	imex:IM-12138|pubmed:18848351	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2106375|imex:IM-12138-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2067|refseq:NP_786930.1|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR001791(Laminin G)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR000082(SEA)|rcsb pdb:3V64|rcsb pdb:3V65|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003884(Factor I membrane attack complex)|interpro:IPR036058|interpro:IPR036364|reactome:R-RNO-1971475|reactome:R-RNO-2022928|reactome:R-RNO-2024096|reactome:R-RNO-3000178|reactome:R-RNO-975634|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002162"(dystroglycan binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0033691"(sialic acid binding)|go:"GO:0035374"(chondroitin sulfate binding)|go:"GO:0036122"(BMP binding)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042383"(sarcolemma)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043113"(receptor clustering)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:0045213"(neurotransmitter receptor metabolic process)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902667"(regulation of axon guidance)|go:"GO:1903277"(negative regulation of sodium ion export across plasma membrane)|go:"GO:1903407"("negative regulation of P-type sodium:potassium-exchanging transporter activity")|go:"GO:2000541"(positive regulation of protein geranylgeranylation)	refseq:NP_001139329.1|refseq:NP_766256.3|ensembl:ENSMUSG00000027253(gene)|ensembl:ENSMUST00000028689(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0008104"(protein localization)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0009986"(cell surface)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030425"(dendrite)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0051124"(synaptic assembly at neuromuscular junction)|go:"GO:0060173"(limb development)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1901631"(positive regulation of presynaptic membrane organization)|go:"GO:1904395"(positive regulation of skeletal muscle acetylcholine-gated channel clustering)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|interpro:IPR026823|interpro:IPR036055|mint:Q8VI56	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3D|caution:Agrin construct was agrin B8 - a neuronal isoform containing a C-terminal amino acid insert. This could not be unambiguously mapped to the existing UniProt isoforms. It is unclear how the Cy5 label is bound and which of the tags present on the original construct are present after this process.|comment:Cells expressing both Lrp4 and Musk bound Agrin more effectively than cells expressing Lrp4 alone.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/11/11	2014/10/16	rogid:FVRnqwtFsDQkLUft9sT/oazcZZM10116	rogid:ZKhXi4AMVjK5LFe+xQHieJ2bomY10090	intact-crc:E6EFA042B7E014A7|rigid:fYfmwc6jixiq0+bB6IXDrL+qGus	false	ha tag:?-?|sufficient binding region:c-c|his tag:n-n|cy5 label:?-?|myc tag:n-n	flag tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8VI56	uniprotkb:Q62838	intact:EBI-2106160|uniprotkb:Q8BPX5|uniprotkb:Q8CBB3|uniprotkb:Q8CCP5|uniprotkb:A2AGT4|ensembl:ENSMUSP00000028689	intact:EBI-2106354	psi-mi:lrp4_mouse(display_long)|uniprotkb:Lrp4(gene name)|psi-mi:Lrp4(display_short)|uniprotkb:Kiaa0816(gene name synonym)|uniprotkb:LDLR dan(gene name synonym)	psi-mi:musk_rat(display_long)|uniprotkb:Musk(gene name)|psi-mi:Musk(display_short)|uniprotkb:Muscle-specific tyrosine protein kinase receptor(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kim et al. (2008)	imex:IM-12138|pubmed:18848351	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2106761|imex:IM-12138-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139329.1|refseq:NP_766256.3|ensembl:ENSMUSG00000027253(gene)|ensembl:ENSMUST00000028689(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0008104"(protein localization)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0009986"(cell surface)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030425"(dendrite)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0051124"(synaptic assembly at neuromuscular junction)|go:"GO:0060173"(limb development)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1901631"(positive regulation of presynaptic membrane organization)|go:"GO:1904395"(positive regulation of skeletal muscle acetylcholine-gated channel clustering)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|interpro:IPR026823|interpro:IPR036055|mint:Q8VI56	rgd:3211|refseq:NP_112323.1|interpro:IPR020067|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR020635|rcsb pdb:1LUF|rcsb pdb:2IEP|rcsb pdb:3HKL|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR036179|interpro:IPR036790|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0007613"(memory)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014850"(response to muscle activity)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032224"(positive regulation of synaptic transmission, cholinergic)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0038062"(protein tyrosine kinase collagen receptor activity)|go:"GO:0042995"(cell projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043235"(receptor complex)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0090102"(cochlea development)|go:"GO:1904395"(positive regulation of skeletal muscle acetylcholine-gated channel clustering)|go:"GO:2000541"(positive regulation of protein geranylgeranylation)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4C|comment:Lrp4 and MuSK interaction was shown to be cis i.e. within the same cell. When expressed in different cells, the interaction was poor.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2008/11/11	2014/10/16	rogid:ZKhXi4AMVjK5LFe+xQHieJ2bomY10090	rogid:NV3O9XtmNH+jheY8vIiWBVHed8s10116	intact-crc:D8D842ECC683666D|rigid:zhLzZnnSc+RDfrtdSJNA9GLHQZ8	false	red fluorescent protein tag:c-c	green fluorescent protein tag:c-c|myc tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)