#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P52594	uniprotkb:P51809	intact:EBI-996560|uniprotkb:Q15277|uniprotkb:Q4VAS0|uniprotkb:Q4VAS1|uniprotkb:Q4VAS3|uniprotkb:Q53QT8|uniprotkb:Q53R11|uniprotkb:B3KUL1|uniprotkb:E9PHX7|ensembl:ENSP00000312059	intact:EBI-1052205|uniprotkb:Q53GY7|uniprotkb:Q7Z409|uniprotkb:Q9H4A7|ensembl:ENSP00000286448	psi-mi:agfg1_human(display_long)|uniprotkb:HIV-1 Rev-binding protein(gene name synonym)|uniprotkb:Rev-interacting protein(gene name synonym)|uniprotkb:Rev/Rex activation domain-binding protein(gene name synonym)|uniprotkb:AGFG1(gene name)|psi-mi:AGFG1(display_short)|uniprotkb:RAB(gene name synonym)|uniprotkb:RIP(gene name synonym)|uniprotkb:HRB(gene name synonym)|uniprotkb:Nucleoporin-like protein RIP(gene name synonym)	psi-mi:vamp7_human(display_long)|uniprotkb:SYBL1(gene name synonym)|uniprotkb:Synaptobrevin-like protein 1(gene name synonym)|uniprotkb:Tetanus-insensitive VAMP(gene name synonym)|uniprotkb:VAMP7(gene name)|psi-mi:VAMP7(display_short)	psi-mi:"MI:0018"(two hybrid)	Pryor et al. (2008)	imex:IM-12122|pubmed:18775314	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1996690|imex:IM-12122-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001128660.1|refseq:NP_001128661.1|refseq:NP_004495.2|ensembl:ENSP00000312059|ensembl:ENST00000373671|ensembl:ENSP00000362775|ensembl:ENST00000409171|ensembl:ENSP00000387218|ensembl:ENST00000409979|ensembl:ENSP00000387282|refseq:NP_001128659.1|go:"GO:0005643"(nuclear pore)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR037278|interpro:IPR038508|rcsb pdb:2D9L|rcsb pdb:2OLM|rcsb pdb:2VX8|reactome:R-HSA-8856825|reactome:R-HSA-8856828|ensembl:ENSG00000173744(gene)|ensembl:ENST00000310078(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|dip:DIP-35546N	refseq:NP_001138621.1|refseq:NP_001172112.1|refseq:NP_005629.1|ensembl:ENSG00000124333(gene)|ensembl:ENST00000286448(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030141"(secretory granule)|go:"GO:0030175"(filopodium)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031143"(pseudopodium)|go:"GO:0031201"(SNARE complex)|go:"GO:0031902"(late endosome membrane)|go:"GO:0034197"(triglyceride transport)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043308"(eosinophil degranulation)|go:"GO:0043312"(neutrophil degranulation)|go:"GO:0043320"(natural killer cell degranulation)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048280"(vesicle fusion with Golgi apparatus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:1903595"(positive regulation of histamine secretion by mast cell)|interpro:IPR001388(Synaptobrevin)|interpro:IPR010908(Longin)|interpro:IPR011012(Longin-like)|interpro:IPR042855|mint:P51809|rcsb pdb:2DMW|reactome:R-HSA-199992|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9020591	psi-mi:"MI:0469"(intact)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/09/23	2014/10/16	rogid:dmA7pBiLW9jnoJellR8WQP1zD6g9606	rogid:iGCiTvDrgrPOV7mOfivnbt02zV89606	intact-crc:F90B20F90120F7F7|rigid:UZaNO8gXaCmQ+AZl9kpI9K9eoZQ	false	-	sufficient binding region:1-120(IPR010908)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51809	uniprotkb:O14617	intact:EBI-1052205|uniprotkb:Q53GY7|uniprotkb:Q7Z409|uniprotkb:Q9H4A7|ensembl:ENSP00000286448	intact:EBI-1051639|uniprotkb:O00202|uniprotkb:O75262|uniprotkb:Q59HF5|uniprotkb:Q96G11|uniprotkb:Q9H3C6|ensembl:ENSP00000344055	psi-mi:vamp7_human(display_long)|uniprotkb:SYBL1(gene name synonym)|uniprotkb:Synaptobrevin-like protein 1(gene name synonym)|uniprotkb:Tetanus-insensitive VAMP(gene name synonym)|uniprotkb:VAMP7(gene name)|psi-mi:VAMP7(display_short)	psi-mi:ap3d1_human(display_long)|uniprotkb:AP-3 complex subunit delta(gene name synonym)|uniprotkb:Delta-adaptin(gene name synonym)|uniprotkb:AP3D1(gene name)|psi-mi:AP3D1(display_short)|uniprotkb:PRO0039(orf name)|uniprotkb:Adaptor-related protein complex 3 subunit delta-1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Pryor et al. (2008)	imex:IM-12122|pubmed:18775314	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1996697|imex:IM-12122-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138621.1|refseq:NP_001172112.1|refseq:NP_005629.1|ensembl:ENSG00000124333(gene)|ensembl:ENST00000286448(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030141"(secretory granule)|go:"GO:0030175"(filopodium)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031143"(pseudopodium)|go:"GO:0031201"(SNARE complex)|go:"GO:0031902"(late endosome membrane)|go:"GO:0034197"(triglyceride transport)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043308"(eosinophil degranulation)|go:"GO:0043312"(neutrophil degranulation)|go:"GO:0043320"(natural killer cell degranulation)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048280"(vesicle fusion with Golgi apparatus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:1903595"(positive regulation of histamine secretion by mast cell)|interpro:IPR001388(Synaptobrevin)|interpro:IPR010908(Longin)|interpro:IPR011012(Longin-like)|interpro:IPR042855|mint:P51809|rcsb pdb:2DMW|reactome:R-HSA-199992|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9020591	refseq:NP_003929.4|refseq:NP_001248755.1|ensembl:ENSG00000065000(gene)|ensembl:ENST00000345016(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0016182"(synaptic vesicle budding from endosome)|go:"GO:0030123"(AP-3 adaptor complex)|go:"GO:0032438"(melanosome organization)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0043195"(terminal bouton)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048007"(antigen processing and presentation, exogenous lipid antigen via MHC class Ib)|go:"GO:0048490"(anterograde synaptic vesicle transport)|go:"GO:0048499"(synaptic vesicle membrane organization)|go:"GO:0051138"(positive regulation of NK T cell differentiation)|go:"GO:0061088"(regulation of sequestering of zinc ion)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098830"(presynaptic endosome)|go:"GO:0098943"(neurotransmitter receptor transport, postsynaptic endosome to lysosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR010474(Bovine leukaemia virus receptor)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017105(Adaptor protein complex AP-3, delta subunit)|mint:O14617|rcsb pdb:4AFI|dip:DIP-46793N	psi-mi:"MI:0469"(intact)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/09/23	2014/10/16	rogid:iGCiTvDrgrPOV7mOfivnbt02zV89606	rogid:vw6bWz07cMYuwATlyDgx14oXzKY9606	intact-crc:D0C5F883CA9FBF71|rigid:M9BSJP6sf0r4nqrsZSJPmq2Y7CM	false	sufficient binding region:1-120(IPR010908)	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P52594	uniprotkb:P51809	intact:EBI-996560|uniprotkb:Q15277|uniprotkb:Q4VAS0|uniprotkb:Q4VAS1|uniprotkb:Q4VAS3|uniprotkb:Q53QT8|uniprotkb:Q53R11|uniprotkb:B3KUL1|uniprotkb:E9PHX7|ensembl:ENSP00000312059	intact:EBI-1052205|uniprotkb:Q53GY7|uniprotkb:Q7Z409|uniprotkb:Q9H4A7|ensembl:ENSP00000286448	psi-mi:agfg1_human(display_long)|uniprotkb:HIV-1 Rev-binding protein(gene name synonym)|uniprotkb:Rev-interacting protein(gene name synonym)|uniprotkb:Rev/Rex activation domain-binding protein(gene name synonym)|uniprotkb:AGFG1(gene name)|psi-mi:AGFG1(display_short)|uniprotkb:RAB(gene name synonym)|uniprotkb:RIP(gene name synonym)|uniprotkb:HRB(gene name synonym)|uniprotkb:Nucleoporin-like protein RIP(gene name synonym)	psi-mi:vamp7_human(display_long)|uniprotkb:SYBL1(gene name synonym)|uniprotkb:Synaptobrevin-like protein 1(gene name synonym)|uniprotkb:Tetanus-insensitive VAMP(gene name synonym)|uniprotkb:VAMP7(gene name)|psi-mi:VAMP7(display_short)	psi-mi:"MI:0018"(two hybrid)	Pryor et al. (2008)	imex:IM-12122|pubmed:18775314	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1996711|imex:IM-12122-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001128660.1|refseq:NP_001128661.1|refseq:NP_004495.2|ensembl:ENSP00000312059|ensembl:ENST00000373671|ensembl:ENSP00000362775|ensembl:ENST00000409171|ensembl:ENSP00000387218|ensembl:ENST00000409979|ensembl:ENSP00000387282|refseq:NP_001128659.1|go:"GO:0005643"(nuclear pore)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR037278|interpro:IPR038508|rcsb pdb:2D9L|rcsb pdb:2OLM|rcsb pdb:2VX8|reactome:R-HSA-8856825|reactome:R-HSA-8856828|ensembl:ENSG00000173744(gene)|ensembl:ENST00000310078(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|dip:DIP-35546N	refseq:NP_001138621.1|refseq:NP_001172112.1|refseq:NP_005629.1|ensembl:ENSG00000124333(gene)|ensembl:ENST00000286448(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030141"(secretory granule)|go:"GO:0030175"(filopodium)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031143"(pseudopodium)|go:"GO:0031201"(SNARE complex)|go:"GO:0031902"(late endosome membrane)|go:"GO:0034197"(triglyceride transport)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043308"(eosinophil degranulation)|go:"GO:0043312"(neutrophil degranulation)|go:"GO:0043320"(natural killer cell degranulation)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048280"(vesicle fusion with Golgi apparatus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:1903595"(positive regulation of histamine secretion by mast cell)|interpro:IPR001388(Synaptobrevin)|interpro:IPR010908(Longin)|interpro:IPR011012(Longin-like)|interpro:IPR042855|mint:P51809|rcsb pdb:2DMW|reactome:R-HSA-199992|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9020591	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/09/23	2014/10/16	rogid:dmA7pBiLW9jnoJellR8WQP1zD6g9606	rogid:iGCiTvDrgrPOV7mOfivnbt02zV89606	intact-crc:1F81DCE25BC4FD43|rigid:UZaNO8gXaCmQ+AZl9kpI9K9eoZQ	false	-	sufficient binding region:1-120(IPR010908)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P52594	uniprotkb:P51809	intact:EBI-996560|uniprotkb:Q15277|uniprotkb:Q4VAS0|uniprotkb:Q4VAS1|uniprotkb:Q4VAS3|uniprotkb:Q53QT8|uniprotkb:Q53R11|uniprotkb:B3KUL1|uniprotkb:E9PHX7|ensembl:ENSP00000312059	intact:EBI-1052205|uniprotkb:Q53GY7|uniprotkb:Q7Z409|uniprotkb:Q9H4A7|ensembl:ENSP00000286448	psi-mi:agfg1_human(display_long)|uniprotkb:HIV-1 Rev-binding protein(gene name synonym)|uniprotkb:Rev-interacting protein(gene name synonym)|uniprotkb:Rev/Rex activation domain-binding protein(gene name synonym)|uniprotkb:AGFG1(gene name)|psi-mi:AGFG1(display_short)|uniprotkb:RAB(gene name synonym)|uniprotkb:RIP(gene name synonym)|uniprotkb:HRB(gene name synonym)|uniprotkb:Nucleoporin-like protein RIP(gene name synonym)	psi-mi:vamp7_human(display_long)|uniprotkb:SYBL1(gene name synonym)|uniprotkb:Synaptobrevin-like protein 1(gene name synonym)|uniprotkb:Tetanus-insensitive VAMP(gene name synonym)|uniprotkb:VAMP7(gene name)|psi-mi:VAMP7(display_short)	psi-mi:"MI:0096"(pull down)	Pryor et al. (2008)	imex:IM-12122|pubmed:18775314	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1996812|imex:IM-12122-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001128660.1|refseq:NP_001128661.1|refseq:NP_004495.2|ensembl:ENSP00000312059|ensembl:ENST00000373671|ensembl:ENSP00000362775|ensembl:ENST00000409171|ensembl:ENSP00000387218|ensembl:ENST00000409979|ensembl:ENSP00000387282|refseq:NP_001128659.1|go:"GO:0005643"(nuclear pore)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR037278|interpro:IPR038508|rcsb pdb:2D9L|rcsb pdb:2OLM|rcsb pdb:2VX8|reactome:R-HSA-8856825|reactome:R-HSA-8856828|ensembl:ENSG00000173744(gene)|ensembl:ENST00000310078(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|dip:DIP-35546N	refseq:NP_001138621.1|refseq:NP_001172112.1|refseq:NP_005629.1|ensembl:ENSG00000124333(gene)|ensembl:ENST00000286448(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030141"(secretory granule)|go:"GO:0030175"(filopodium)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031143"(pseudopodium)|go:"GO:0031201"(SNARE complex)|go:"GO:0031902"(late endosome membrane)|go:"GO:0034197"(triglyceride transport)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043308"(eosinophil degranulation)|go:"GO:0043312"(neutrophil degranulation)|go:"GO:0043320"(natural killer cell degranulation)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048280"(vesicle fusion with Golgi apparatus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:1903595"(positive regulation of histamine secretion by mast cell)|interpro:IPR001388(Synaptobrevin)|interpro:IPR010908(Longin)|interpro:IPR011012(Longin-like)|interpro:IPR042855|mint:P51809|rcsb pdb:2DMW|reactome:R-HSA-199992|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9020591	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figs. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/09/23	2014/10/16	rogid:dmA7pBiLW9jnoJellR8WQP1zD6g9606	rogid:iGCiTvDrgrPOV7mOfivnbt02zV89606	intact-crc:397387B59EE89284|rigid:UZaNO8gXaCmQ+AZl9kpI9K9eoZQ	false	-	sufficient binding region:1-120(IPR010908)|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P52594	uniprotkb:P51809	intact:EBI-996560|uniprotkb:Q15277|uniprotkb:Q4VAS0|uniprotkb:Q4VAS1|uniprotkb:Q4VAS3|uniprotkb:Q53QT8|uniprotkb:Q53R11|uniprotkb:B3KUL1|uniprotkb:E9PHX7|ensembl:ENSP00000312059	intact:EBI-1052205|uniprotkb:Q53GY7|uniprotkb:Q7Z409|uniprotkb:Q9H4A7|ensembl:ENSP00000286448	psi-mi:agfg1_human(display_long)|uniprotkb:HIV-1 Rev-binding protein(gene name synonym)|uniprotkb:Rev-interacting protein(gene name synonym)|uniprotkb:Rev/Rex activation domain-binding protein(gene name synonym)|uniprotkb:AGFG1(gene name)|psi-mi:AGFG1(display_short)|uniprotkb:RAB(gene name synonym)|uniprotkb:RIP(gene name synonym)|uniprotkb:HRB(gene name synonym)|uniprotkb:Nucleoporin-like protein RIP(gene name synonym)	psi-mi:vamp7_human(display_long)|uniprotkb:SYBL1(gene name synonym)|uniprotkb:Synaptobrevin-like protein 1(gene name synonym)|uniprotkb:Tetanus-insensitive VAMP(gene name synonym)|uniprotkb:VAMP7(gene name)|psi-mi:VAMP7(display_short)	psi-mi:"MI:0096"(pull down)	Pryor et al. (2008)	imex:IM-12122|pubmed:18775314	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1996725|imex:IM-12122-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001128660.1|refseq:NP_001128661.1|refseq:NP_004495.2|ensembl:ENSP00000312059|ensembl:ENST00000373671|ensembl:ENSP00000362775|ensembl:ENST00000409171|ensembl:ENSP00000387218|ensembl:ENST00000409979|ensembl:ENSP00000387282|refseq:NP_001128659.1|go:"GO:0005643"(nuclear pore)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR037278|interpro:IPR038508|rcsb pdb:2D9L|rcsb pdb:2OLM|rcsb pdb:2VX8|reactome:R-HSA-8856825|reactome:R-HSA-8856828|ensembl:ENSG00000173744(gene)|ensembl:ENST00000310078(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|dip:DIP-35546N	refseq:NP_001138621.1|refseq:NP_001172112.1|refseq:NP_005629.1|ensembl:ENSG00000124333(gene)|ensembl:ENST00000286448(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030141"(secretory granule)|go:"GO:0030175"(filopodium)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031143"(pseudopodium)|go:"GO:0031201"(SNARE complex)|go:"GO:0031902"(late endosome membrane)|go:"GO:0034197"(triglyceride transport)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043308"(eosinophil degranulation)|go:"GO:0043312"(neutrophil degranulation)|go:"GO:0043320"(natural killer cell degranulation)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048280"(vesicle fusion with Golgi apparatus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:1903595"(positive regulation of histamine secretion by mast cell)|interpro:IPR001388(Synaptobrevin)|interpro:IPR010908(Longin)|interpro:IPR011012(Longin-like)|interpro:IPR042855|mint:P51809|rcsb pdb:2DMW|reactome:R-HSA-199992|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9020591	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figs. 1D, 1E, 7B, 7C|comment:"The full-length, wild-type cytoplasmic domain of VAMP7 does not bind HRB due to the intramolecular binding of the VAMP7 SNARE helix onto its longin domain. Mutations (Ile139, Met140, Ile144 -> Ser) prevents intramolecular binding and allows HRB binding."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/09/23	2014/10/16	rogid:dmA7pBiLW9jnoJellR8WQP1zD6g9606	rogid:iGCiTvDrgrPOV7mOfivnbt02zV89606	intact-crc:3929576BD4B92725|rigid:UZaNO8gXaCmQ+AZl9kpI9K9eoZQ	false	his tag:c-c|sufficient binding region:136-176	sufficient binding region:1-120(IPR010908)|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P52594	uniprotkb:P51809	intact:EBI-996560|uniprotkb:Q15277|uniprotkb:Q4VAS0|uniprotkb:Q4VAS1|uniprotkb:Q4VAS3|uniprotkb:Q53QT8|uniprotkb:Q53R11|uniprotkb:B3KUL1|uniprotkb:E9PHX7|ensembl:ENSP00000312059	intact:EBI-1052205|uniprotkb:Q53GY7|uniprotkb:Q7Z409|uniprotkb:Q9H4A7|ensembl:ENSP00000286448	psi-mi:agfg1_human(display_long)|uniprotkb:HIV-1 Rev-binding protein(gene name synonym)|uniprotkb:Rev-interacting protein(gene name synonym)|uniprotkb:Rev/Rex activation domain-binding protein(gene name synonym)|uniprotkb:AGFG1(gene name)|psi-mi:AGFG1(display_short)|uniprotkb:RAB(gene name synonym)|uniprotkb:RIP(gene name synonym)|uniprotkb:HRB(gene name synonym)|uniprotkb:Nucleoporin-like protein RIP(gene name synonym)	psi-mi:vamp7_human(display_long)|uniprotkb:SYBL1(gene name synonym)|uniprotkb:Synaptobrevin-like protein 1(gene name synonym)|uniprotkb:Tetanus-insensitive VAMP(gene name synonym)|uniprotkb:VAMP7(gene name)|psi-mi:VAMP7(display_short)	psi-mi:"MI:0096"(pull down)	Pryor et al. (2008)	imex:IM-12122|pubmed:18775314	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1996994|imex:IM-12122-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001128660.1|refseq:NP_001128661.1|refseq:NP_004495.2|ensembl:ENSP00000312059|ensembl:ENST00000373671|ensembl:ENSP00000362775|ensembl:ENST00000409171|ensembl:ENSP00000387218|ensembl:ENST00000409979|ensembl:ENSP00000387282|refseq:NP_001128659.1|go:"GO:0005643"(nuclear pore)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR037278|interpro:IPR038508|rcsb pdb:2D9L|rcsb pdb:2OLM|rcsb pdb:2VX8|reactome:R-HSA-8856825|reactome:R-HSA-8856828|ensembl:ENSG00000173744(gene)|ensembl:ENST00000310078(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|dip:DIP-35546N	refseq:NP_001138621.1|refseq:NP_001172112.1|refseq:NP_005629.1|ensembl:ENSG00000124333(gene)|ensembl:ENST00000286448(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030141"(secretory granule)|go:"GO:0030175"(filopodium)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031143"(pseudopodium)|go:"GO:0031201"(SNARE complex)|go:"GO:0031902"(late endosome membrane)|go:"GO:0034197"(triglyceride transport)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043308"(eosinophil degranulation)|go:"GO:0043312"(neutrophil degranulation)|go:"GO:0043320"(natural killer cell degranulation)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048280"(vesicle fusion with Golgi apparatus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:1903595"(positive regulation of histamine secretion by mast cell)|interpro:IPR001388(Synaptobrevin)|interpro:IPR010908(Longin)|interpro:IPR011012(Longin-like)|interpro:IPR042855|mint:P51809|rcsb pdb:2DMW|reactome:R-HSA-199992|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9020591	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 2D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/09/23	2014/10/16	rogid:dmA7pBiLW9jnoJellR8WQP1zD6g9606	rogid:iGCiTvDrgrPOV7mOfivnbt02zV89606	intact-crc:4611DB6F7DD9951F|rigid:UZaNO8gXaCmQ+AZl9kpI9K9eoZQ	false	glutathione s tranferase tag:?-?|sufficient binding region:1-176	sufficient binding region:1-120(IPR010908)|his tag:?-?|mutation decreasing interaction:43-43,45-45	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P52594	uniprotkb:P51809	intact:EBI-996560|uniprotkb:Q15277|uniprotkb:Q4VAS0|uniprotkb:Q4VAS1|uniprotkb:Q4VAS3|uniprotkb:Q53QT8|uniprotkb:Q53R11|uniprotkb:B3KUL1|uniprotkb:E9PHX7|ensembl:ENSP00000312059	intact:EBI-1052205|uniprotkb:Q53GY7|uniprotkb:Q7Z409|uniprotkb:Q9H4A7|ensembl:ENSP00000286448	psi-mi:agfg1_human(display_long)|uniprotkb:HIV-1 Rev-binding protein(gene name synonym)|uniprotkb:Rev-interacting protein(gene name synonym)|uniprotkb:Rev/Rex activation domain-binding protein(gene name synonym)|uniprotkb:AGFG1(gene name)|psi-mi:AGFG1(display_short)|uniprotkb:RAB(gene name synonym)|uniprotkb:RIP(gene name synonym)|uniprotkb:HRB(gene name synonym)|uniprotkb:Nucleoporin-like protein RIP(gene name synonym)	psi-mi:vamp7_human(display_long)|uniprotkb:SYBL1(gene name synonym)|uniprotkb:Synaptobrevin-like protein 1(gene name synonym)|uniprotkb:Tetanus-insensitive VAMP(gene name synonym)|uniprotkb:VAMP7(gene name)|psi-mi:VAMP7(display_short)	psi-mi:"MI:0096"(pull down)	Pryor et al. (2008)	imex:IM-12122|pubmed:18775314	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1997012|imex:IM-12122-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001128660.1|refseq:NP_001128661.1|refseq:NP_004495.2|ensembl:ENSP00000312059|ensembl:ENST00000373671|ensembl:ENSP00000362775|ensembl:ENST00000409171|ensembl:ENSP00000387218|ensembl:ENST00000409979|ensembl:ENSP00000387282|refseq:NP_001128659.1|go:"GO:0005643"(nuclear pore)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR037278|interpro:IPR038508|rcsb pdb:2D9L|rcsb pdb:2OLM|rcsb pdb:2VX8|reactome:R-HSA-8856825|reactome:R-HSA-8856828|ensembl:ENSG00000173744(gene)|ensembl:ENST00000310078(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|dip:DIP-35546N	refseq:NP_001138621.1|refseq:NP_001172112.1|refseq:NP_005629.1|ensembl:ENSG00000124333(gene)|ensembl:ENST00000286448(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030141"(secretory granule)|go:"GO:0030175"(filopodium)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031143"(pseudopodium)|go:"GO:0031201"(SNARE complex)|go:"GO:0031902"(late endosome membrane)|go:"GO:0034197"(triglyceride transport)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043308"(eosinophil degranulation)|go:"GO:0043312"(neutrophil degranulation)|go:"GO:0043320"(natural killer cell degranulation)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048280"(vesicle fusion with Golgi apparatus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:1903595"(positive regulation of histamine secretion by mast cell)|interpro:IPR001388(Synaptobrevin)|interpro:IPR010908(Longin)|interpro:IPR011012(Longin-like)|interpro:IPR042855|mint:P51809|rcsb pdb:2DMW|reactome:R-HSA-199992|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9020591	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 2E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/09/23	2014/10/16	rogid:dmA7pBiLW9jnoJellR8WQP1zD6g9606	rogid:iGCiTvDrgrPOV7mOfivnbt02zV89606	intact-crc:CFCEF88866EB33EB|rigid:UZaNO8gXaCmQ+AZl9kpI9K9eoZQ	false	his tag:c-c|sufficient binding region:1-176|mutation decreasing interaction:163-163,160-160|mutation decreasing interaction:164-164,163-163|mutation decreasing interaction:171-171,173-173	sufficient binding region:1-120(IPR010908)|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P52594	uniprotkb:P51809	intact:EBI-996560|uniprotkb:Q15277|uniprotkb:Q4VAS0|uniprotkb:Q4VAS1|uniprotkb:Q4VAS3|uniprotkb:Q53QT8|uniprotkb:Q53R11|uniprotkb:B3KUL1|uniprotkb:E9PHX7|ensembl:ENSP00000312059	intact:EBI-1052205|uniprotkb:Q53GY7|uniprotkb:Q7Z409|uniprotkb:Q9H4A7|ensembl:ENSP00000286448	psi-mi:agfg1_human(display_long)|uniprotkb:HIV-1 Rev-binding protein(gene name synonym)|uniprotkb:Rev-interacting protein(gene name synonym)|uniprotkb:Rev/Rex activation domain-binding protein(gene name synonym)|uniprotkb:AGFG1(gene name)|psi-mi:AGFG1(display_short)|uniprotkb:RAB(gene name synonym)|uniprotkb:RIP(gene name synonym)|uniprotkb:HRB(gene name synonym)|uniprotkb:Nucleoporin-like protein RIP(gene name synonym)	psi-mi:vamp7_human(display_long)|uniprotkb:SYBL1(gene name synonym)|uniprotkb:Synaptobrevin-like protein 1(gene name synonym)|uniprotkb:Tetanus-insensitive VAMP(gene name synonym)|uniprotkb:VAMP7(gene name)|psi-mi:VAMP7(display_short)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Pryor et al. (2008)	imex:IM-12122|pubmed:18775314	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1996828|imex:IM-12122-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001128660.1|refseq:NP_001128661.1|refseq:NP_004495.2|ensembl:ENSP00000312059|ensembl:ENST00000373671|ensembl:ENSP00000362775|ensembl:ENST00000409171|ensembl:ENSP00000387218|ensembl:ENST00000409979|ensembl:ENSP00000387282|refseq:NP_001128659.1|go:"GO:0005643"(nuclear pore)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR037278|interpro:IPR038508|rcsb pdb:2D9L|rcsb pdb:2OLM|rcsb pdb:2VX8|reactome:R-HSA-8856825|reactome:R-HSA-8856828|ensembl:ENSG00000173744(gene)|ensembl:ENST00000310078(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|dip:DIP-35546N	refseq:NP_001138621.1|refseq:NP_001172112.1|refseq:NP_005629.1|ensembl:ENSG00000124333(gene)|ensembl:ENST00000286448(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030141"(secretory granule)|go:"GO:0030175"(filopodium)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031143"(pseudopodium)|go:"GO:0031201"(SNARE complex)|go:"GO:0031902"(late endosome membrane)|go:"GO:0034197"(triglyceride transport)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043308"(eosinophil degranulation)|go:"GO:0043312"(neutrophil degranulation)|go:"GO:0043320"(natural killer cell degranulation)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048280"(vesicle fusion with Golgi apparatus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:1903595"(positive regulation of histamine secretion by mast cell)|interpro:IPR001388(Synaptobrevin)|interpro:IPR010908(Longin)|interpro:IPR011012(Longin-like)|interpro:IPR042855|mint:P51809|rcsb pdb:2DMW|reactome:R-HSA-199992|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9020591	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figs. 4C|comment:All mutation increased the Kd to >3E-4M.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/09/23	2014/10/16	rogid:dmA7pBiLW9jnoJellR8WQP1zD6g9606	rogid:iGCiTvDrgrPOV7mOfivnbt02zV89606	intact-crc:77D4387B589B0AFB|rigid:UZaNO8gXaCmQ+AZl9kpI9K9eoZQ	false	his tag:c-c|sufficient binding region:1-176|mutation decreasing interaction:163-163,160-160|mutation decreasing interaction:163-163,164-164|mutation decreasing interaction:171-171,173-173	sufficient binding region:1-120(IPR010908)|mutation decreasing interaction:45-45,43-43	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-1996897	-	-	-	psi-mi:vamp7_hrb fusion(display_short)|psi-mi:EBI-1996897(display_long)	-	psi-mi:"MI:0114"(x-ray crystallography)	Pryor et al. (2008)	imex:IM-12122|pubmed:18775314	taxid:9606(human)|taxid:9606(Homo sapiens)	-	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1996916|wwpdb:2vx8|imex:IM-12122-9	-	-	psi-mi:"MI:0499"(unspecified role)	-	psi-mi:"MI:0503"(self)	-	psi-mi:"MI:0326"(protein)	-	uniprotkb:P52594(see-also)|uniprotkb:P70280(see-also)	-	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt	-	3d-r-factors:working 22.0%, free 28.0%|3d-resolution:2.2A|figure legend:Fig. 3, Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/09/23	2014/10/16	rogid:EQEBcRbcMzHWmvLFelUjPjzjJD49606	-	intact-crc:17CFF80C04FA94ED	false	his tag:c-c	-	-	-	psi-mi:"MI:0396"(predetermined participant)	-