#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P61224	uniprotkb:O95398	intact:EBI-358143|intact:EBI-1047928|uniprotkb:P09526|uniprotkb:Q6DCA1|uniprotkb:Q6LES0|uniprotkb:Q502X3|uniprotkb:Q5TZR4|uniprotkb:B2R5Z2|intact:EBI-11037134|uniprotkb:B4DQI8|uniprotkb:B4DW74|uniprotkb:B4DW94|ensembl:ENSP00000250559|ensembl:ENSP00000377085|ensembl:ENSP00000439966|ensembl:ENSP00000441275	intact:EBI-6172806|ensembl:ENSP00000373864|ensembl:ENSP00000395708|uniprotkb:O95634|uniprotkb:Q8WVN0|uniprotkb:A8K2G5|uniprotkb:E7EQC8	psi-mi:rap1b_human(display_long)|uniprotkb:OK/SW-cl.11(orf name)|uniprotkb:RAP1B(gene name)|psi-mi:RAP1B(display_short)|uniprotkb:GTP-binding protein smg p21B(gene name synonym)	psi-mi:rpgf3_human(display_long)|uniprotkb:RAPGEF3(gene name)|psi-mi:RAPGEF3(display_short)|uniprotkb:CGEF1(gene name synonym)|uniprotkb:EPAC(gene name synonym)|uniprotkb:EPAC1(gene name synonym)|uniprotkb:Exchange factor directly activated by cAMP 1(gene name synonym)|uniprotkb:Exchange protein directly activated by cAMP 1(gene name synonym)|uniprotkb:Rap1 guanine-nucleotide-exchange factor directly activated by cAMP(gene name synonym)|uniprotkb:cAMP-regulated guanine nucleotide exchange factor I(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rehmann et al. (2008)	pubmed:18692051|imex:IM-9575|mint:MINT-6741766|doi:10.1016/j.febslet.2008.07.057	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8051601|mint:MINT-6741806|imex:IM-9575-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001010942.1|refseq:NP_056461.1|dip:DIP-35407N|refseq:NP_001238846.1|refseq:NP_001238847.1|refseq:NP_001238850.1|refseq:NP_001238851.1|ensembl:ENSG00000127314(gene)|ensembl:ENST00000250559(transcript)|ensembl:ENST00000341355(transcript)|ensembl:ENST00000393436(transcript)|ensembl:ENST00000537460(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0032486"(Rap protein signal transduction)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035690"|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0097211"(cellular response to gonadotropin-releasing hormone)|go:"GO:1901888"(regulation of cell junction assembly)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR038851|mint:P61224|rcsb pdb:3BRW|rcsb pdb:3CF6|rcsb pdb:4DXA|rcsb pdb:4HDO|rcsb pdb:4HDQ|rcsb pdb:4M8N|rcsb pdb:4MGI|rcsb pdb:4MGK|rcsb pdb:4MGY|rcsb pdb:4MGZ|rcsb pdb:4MH0|rcsb pdb:5KHO|rcsb pdb:6AXF|rcsb pdb:6BA6|rcsb pdb:6KYK|rcsb pdb:6OQ3|rcsb pdb:6OQ4|rcsb pdb:6UZK|rcsb pdb:7C7I|rcsb pdb:7C7J|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-392517|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8875555|reactome:R-HSA-8950505|reactome:R-HSA-9649948|reactome:R-HSA-9656223|mint:MINT-6741809(identity)	ensembl:ENSG00000079337(gene)|ensembl:ENST00000389212(transcript)|ensembl:ENST00000449771(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007165"(signal transduction)|go:"GO:0012505"(endomembrane system)|interpro:IPR036388|interpro:IPR036390|interpro:IPR036964|mint:O95398|rcsb pdb:6H7E|reactome:R-HSA-354192|reactome:R-HSA-381676|reactome:R-HSA-392517|reactome:R-HSA-422356|go:"GO:0016020"(membrane)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030552"(cAMP binding)|go:"GO:0032486"(Rap protein signal transduction)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034242"(negative regulation of syncytium formation by plasma membrane fusion)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0060143"(positive regulation of syncytium formation by plasma membrane fusion)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:1901985"(positive regulation of protein acetylation)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018490|interpro:IPR019804|interpro:IPR023578|interpro:IPR029071|refseq:NP_001092002.1|refseq:NP_006096.2|mint:MINT-6741808(identity)	-	-	-	figure legend:F2B|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2008/07/29	2014/10/16	rogid:CiuN7je+CaRH9QKDiR3vrzcJ87g9606	rogid:JTvCAJZQHQvt9s2Z2GDOszHq0pk9606	intact-crc:D25883120F7926A2|rigid:ScuGGM4W4P713rFVRBYwRjeSQH8	false	ha tag:?-?(MINT-6741810)	yellow fluorescent protein tag:?-?(MINT-6741814)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)